<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QV88</accession>
    <name>A0A2Z5QV88_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="1">MECDP-synthase</shortName>
            <shortName evidence="1">MECPP-synthase</shortName>
            <shortName evidence="1">MECPS</shortName>
            <ecNumber evidence="1 2">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispF</name>
        <name evidence="4" type="ORF">RA11412_0006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="1 2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86305">
        <property type="protein sequence ID" value="BAV86305"/>
        <property type="gene ID" value="RA11412_0006"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0006"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="1">
        <location>
            <begin position="27"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="1">
        <location>
            <begin position="49"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="1">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="148" mass="14995" checksum="BB6C1E0D0E4844DB" modified="2018-10-10" version="1">MHAFGEENTELWIAGLYWPGERGLSGHSDGDVVAHAAADALFTASGTGDLGSNFGVDRPDMAGASGVRILSEAAAIVRAAGFEIGNISVQLIGNRPKFSPRRAEANRVLSEAAGASVTVTATTTDGLGLTGRGEGVAAVATALLYPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVC3</accession>
    <name>A0A2Z5QVC3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86337">
        <property type="protein sequence ID" value="BAV86337"/>
        <property type="gene ID" value="RA11412_0038"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0038"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="374" mass="42717" checksum="010B6DBAD36972D4" modified="2018-10-10" version="1">MAAILQENFVPRSEPCETPFSRADTTQQIKDTKSQKTDYHTSAEIHQRTEDTNPQKQQTSQPTPTPSRPTPTAPKPAVTEAQQRNHPDIKRPIPQPPSSPLPKLAEVSKAEPKTPTGPIPSPTALAGKFKPLTYKPPAIAEYYATKPSRGARHGEAAGERVWPLKEVEAIAPYTVSQEKHTDLLDTERLSKTLGDQYYLRGTKRDSLLRRLHKTQHRAVPHPEASGSKYPEIRPEMLKHIKELNLDYEDIKRFIDCGVPEKINGWTTHYRYDDYRVELNTSSNTVLNVEDERDFYDEFLDDTSEEKLPYTFAPAVEHYMVMHSIPYNRVIRIIEEPKSVDPAPSWLTAYSDHEYRVFVAPDGRTIRSIKPLKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVF6</accession>
    <name>A0A2Z5QVF6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidophosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86377">
        <property type="protein sequence ID" value="BAV86377"/>
        <property type="gene ID" value="RA11412_0078"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0078"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="258" mass="27248" checksum="2BDFDF0061150B3C" modified="2018-10-10" version="1">MKNAYVGRTFIQPSQTIRQLGIRLKLNPLKSVVAGKRLIVIDDSIVRGNTQRALVRMLREAGAKEVHVRISSPPVKWPCFYGIDFASRAELIANGLSVNEIAASLGADSLGFISQDGMMAATEQPTRNMCTACFTGNYPIELPAEERRGKSLFDASESKGGPLSGMAAEVTVERPVPTKPEHAEAVSIETRAGTDSLEHKFESSPLPAAPAGGGEPAPGQHAPAGGMCNPGPDADLEALLTDDDLVPASATKTATDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVH3</accession>
    <name>A0A2Z5QVH3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable queuosine precursor transporter</fullName>
            <shortName evidence="1">Q precursor transporter</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07890</name>
        <name evidence="2" type="ORF">RA11412_0067</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037236931.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86366">
        <property type="protein sequence ID" value="BAV86366"/>
        <property type="gene ID" value="RA11412_0067"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0067"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990397">
        <property type="term" value="P:queuosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02088">
        <property type="entry name" value="Q_prec_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003744">
        <property type="entry name" value="YhhQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34300">
        <property type="entry name" value="PTHR34300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02592">
        <property type="entry name" value="Vut_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00697">
        <property type="entry name" value="TIGR00697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="244" mass="26770" checksum="FD3D7B12E66E2617" modified="2018-10-10" version="1">MSTPTNEARPDTTNVPVPWAGKRRYFDLLLGASCVILIISNIAATKSIEFGPLPFEFPPFTNGNFIPSDGGFFLYPLAYVLGDVLSEVYGFKRARRAIIASFVAAAFAAGCFLLTVALPPASYYANQEAFAIILGPVWQIFAGSLLGYLTGQLLNAWVMVAMKKATSGRFMWARMIASTLVGELADTIIFCAIASPILGITTLDQFISYTLVGYVYKCLVEIVLMPISYPVIGWFKRHEVEYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVN2</accession>
    <name>A0A2Z5QVN2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase of siderophore biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86436">
        <property type="protein sequence ID" value="BAV86436"/>
        <property type="gene ID" value="RA11412_0137"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0137"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008908">
        <property type="term" value="F:isochorismatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016291">
        <property type="entry name" value="Isochorismatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01398">
        <property type="entry name" value="ISCHRISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="205" mass="22939" checksum="FF9D3ABAD06FD9F9" modified="2018-10-10" version="1">MALPKKIAPYSYRDQEHQNRVNWRVDPARAALLVHDMQRYFVRAFELERNGQTLPDAQINIAIANIRRLVDAAHAANIPVYYTAQPPRQNPADRRLLTDFWGDGLQDDESAQILDELAPPRPILCSPNGVTQPSCAPRSKNSSKSLGVTSSSSAECTHILAASPPPWRRSCAIFSRSWWRMRSPTSPRKSTVWPANTPRADAPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVT4</accession>
    <name>A0A2Z5QVT4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86491">
        <property type="protein sequence ID" value="BAV86491"/>
        <property type="gene ID" value="RA11412_0192"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0192"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="179" mass="19150" checksum="A29BC41F1AC00993" modified="2018-10-10" version="1">MSQIFNLPDVGEGLTEAEILAWKVAPGDTVHINDVLVEIETAKSVVELPSPYEGSVEQLLAAEGDTVEVGTPIIAVAGSSESAGSSAPPHPALIPVLPKHPRRKPVTRRSLVRAPRQTRLSAVPVNAPHLPPNRSRRPPPRSSPPRWGTHPPPPSRVPGCWVGSADGRSGPVNSWRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVW6</accession>
    <name>A0A2Z5QVW6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86555">
        <property type="protein sequence ID" value="BAV86555"/>
        <property type="gene ID" value="RA11412_0256"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0256"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="56" mass="6538" checksum="0F91CF01B3CA90FD" modified="2018-10-10" version="1">MVGNDFEDGYLIQCSIQSVRSLLDFLVEYPGENYLIDTEEKWCICVYDYLDFGTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW06</accession>
    <name>A0A2Z5QW06_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86571">
        <property type="protein sequence ID" value="BAV86571"/>
        <property type="gene ID" value="RA11412_0272"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0272"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="71" mass="7567" checksum="49042A5A24A210BA" modified="2018-10-10" version="1">MTEPTSNPNDSRINLDKTEQPSHPSEPQPDPHPQSYQGPAVGQPPAPVPYAAPTRASILTLLSTGRLTPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW21</accession>
    <name>A0A2Z5QW21_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PhnB protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06830</name>
        <name evidence="2" type="ORF">RA11412_0308</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86607">
        <property type="protein sequence ID" value="BAV86607"/>
        <property type="gene ID" value="RA11412_0308"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0308"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="12"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="144" mass="16140" checksum="DB44822C9F456132" modified="2018-10-10" version="1">MAQMNVYLSNHQGTTREAFDFYEELFGAQRDGLIRYRDMADALKSAGMYKEEWGEKIAHTALKFNNMTLMGSDVMAEEAPEGAPASFLVYSADSVPDADRVFAALSEGGTVLYPLEMQVWEAYDGCCIDRFGTAWEVMYEGQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW26</accession>
    <name>A0A2Z5QW26_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Possible excisionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06900</name>
        <name evidence="2" type="ORF">RA11412_0293</name>
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    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="BAV86592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT88273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86592">
        <property type="protein sequence ID" value="BAV86592"/>
        <property type="gene ID" value="RA11412_0293"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0293"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="80"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="151" mass="16911" checksum="63CC4C560AAEF601" modified="2018-10-10" version="1">MTTSTLTRADLNDPQLREEVQKLVPGARDTHGDTTEVSFFLQVQGKDSEELGPKLSELIRELIAAVRSGADLAIVSQARVFTTTAAAKELGISRPTLVKMIRNGEIPAHKVGSHFRIMREDLESYQRAQLERQKQALMKIWDIEAELGIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW43</accession>
    <name>A0A2Z5QW43_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86600">
        <property type="protein sequence ID" value="BAV86600"/>
        <property type="gene ID" value="RA11412_0301"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0301"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="146" mass="15568" checksum="C45A2DDA45A04369" modified="2018-10-10" version="1">MKYLSLAPFAALAAIMQAITIYSYDQDAMAVAGQIFFPVLFTLMALYLMLKNPGGSAKLTLVMAIELVISALTFVGSSQKIAALYPSIIVYYVALAALALEVAARIADTPKRAKASADGDDTPKPTAPQRNKNTTARASTTRTKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW65</accession>
    <name>A0A2Z5QW65_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_06935</name>
        <name evidence="8" type="ORF">RA11412_0284</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86583">
        <property type="protein sequence ID" value="BAV86583"/>
        <property type="gene ID" value="RA11412_0284"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0284"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="6"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="546" mass="60444" checksum="E7BCBC34DB397C6F" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW74</accession>
    <name>A0A2Z5QW74_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86544">
        <property type="protein sequence ID" value="BAV86544"/>
        <property type="gene ID" value="RA11412_0245"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0245"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="49" mass="5960" checksum="751A79B376413448" modified="2018-10-10" version="1">MSEKFFSKNINNDDYFILEDDEFIAEINAFFQLTKLSIEVKNFYGFFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWB3</accession>
    <name>A0A2Z5QWB3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06480</name>
        <name evidence="2" type="ORF">RA11412_0399</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86698">
        <property type="protein sequence ID" value="BAV86698"/>
        <property type="gene ID" value="RA11412_0399"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0399"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT90121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="106" mass="12001" checksum="899CF0BCB6B8B921" modified="2018-10-10" version="1">MIFIVVKFPVKPEYAEKWLDLTRDFTEATRAEAGNKWFEWSRSVEDPNEFVLVEAFEDDGAAAHVNSAHFAQAITDMRPALRATPKIVSRQIDGDGWDAMGELTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWG2</accession>
    <name>A0A2Z5QWG2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Phage lysin N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_06550</name>
        <name evidence="3" type="ORF">RA11412_0384</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86683">
        <property type="protein sequence ID" value="BAV86683"/>
        <property type="gene ID" value="RA11412_0384"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0384"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018537">
        <property type="entry name" value="Peptidoglycan-bd_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09374">
        <property type="entry name" value="PG_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033777407" evidence="1">
        <location>
            <begin position="44"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_3" evidence="2">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="167" mass="16979" checksum="46374A7A5EE018CB" modified="2018-10-10" version="1">MTNEHSGVSRRKLLRTAAIGVPVVGAAAFGASLATAPAATALAEDGYWGSETTVELQKHLNSVAAANSAVVGGLPLDGRIDSQPASQSSANPGLTGGWQWVSDDAASGSDTIKDLQRWLGVNADGLIGPNTISALQSYLGQTADGVLDAPSPAIVALQRKLLSSNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWK8</accession>
    <name>A0A2Z5QWK8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome (Plasmid) partitioning protein ParA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">ParA family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Sporulation initiation inhibitor protein soj</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">soj_3</name>
        <name evidence="3" type="ORF">I6I94_06185</name>
        <name evidence="4" type="ORF">NCTC10207_02421</name>
        <name evidence="2" type="ORF">RA11412_0472</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI25106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887405.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86771">
        <property type="protein sequence ID" value="BAV86771"/>
        <property type="gene ID" value="RA11412_0472"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0472"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="21"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI25106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="279" mass="30594" checksum="3F7029BD0BB95429" modified="2018-10-10" version="1">MTEQATDNGSLYTLSKPAHTRILTISNQKGGVGKTSTAVNLAAALAEAGMNVLVIDNDPQGNASTALGIEHDVETPSMYNVLIDDKPLHEIVQTCPDLEGLWCAPANIDLAGAEIELVSMVARETRLKGALEDYSTWRESHNLPRLDYVLIDCPPSLGLLTVNAFVSADEILIPIQCEYYALEGLSQLLKNIEMIQKHLNSRLRISTILLTMYDGRTNLAAQVADEVREHFPTETLQTLIPRSVRISEAPSYQQTVITYDPASTGAQAYREAAREVAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWM1</accession>
    <name>A0A2Z5QWM1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted biotin repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86802">
        <property type="protein sequence ID" value="BAV86802"/>
        <property type="gene ID" value="RA11412_0503"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0503"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
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    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="202" mass="22262" checksum="07164C37CA17E7C8" modified="2018-10-10" version="1">MIRFNGGCGARRILGVALSRDKILHTAYEVLATYGLADLSMRRLASELQVAPGALYYHVRSKQHLLVLLSDYILAHAPDQLHAPCSAGSADAVRSCLMRRGEILFSVLYPIRECPEVIRLALTLHPGSVVLVRVLSADLHLLGFSGERAQRQARLLAHLVLSLIEEAQTLPLLDPEGAHTYSEALERYREDMQCAVDSIIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWN9</accession>
    <name>A0A2Z5QWN9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-glucoside bgl operon antiterminator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">PRD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05920</name>
        <name evidence="2" type="ORF">RA11412_0523</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86822">
        <property type="protein sequence ID" value="BAV86822"/>
        <property type="gene ID" value="RA11412_0523"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0523"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.24.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004341">
        <property type="entry name" value="CAT_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036650">
        <property type="entry name" value="CAT_RNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03123">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01061">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50151">
        <property type="entry name" value="SSF50151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="65"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="171"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="288" mass="31925" checksum="922E557FFC1173EF" modified="2018-10-10" version="1">MRISRIYNNNVALTVDTFGKQAVVIGRGLAFGKRKGDMVDPAKVEQTFVPEQGISAERLSWSLSEIPADILAIATEIEGDTRNDTEIELSNSFIIPFADHLHYAVIRARDGLRVDYPLAPEVNLLYPHEVTYGHRALNLVRKRMGVELNTNEAIPLALHLVNAQFATADMSRAFRMTEVFAQVFEVIEVAYRRAIDPASMSAARFITHLRYLFVRADQGKIGAAGAGISQPSLLAALRADAPRAYACAQKVLLLLEMQLQQPLTQDELTYLTIHIDRLAKDLWGAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWQ4</accession>
    <name>A0A2Z5QWQ4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein MviN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0464</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86763">
        <property type="protein sequence ID" value="BAV86763"/>
        <property type="gene ID" value="RA11412_0464"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0464"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="297" mass="31894" checksum="8E1CB9F8E5DED8DE" modified="2018-10-10" version="1">MANLSFMYMNQVAASVVGERARYAEMGIQIPGLQALNYASMLYILPHGVIGMSIATVLFNRMSASASADDRDSVIHAVSHGLRTSGVATIFCAVALIVLAGPVAILFSGGDRVAATIIAKLIVIMALGTPTLTVTFLYGRVLYAREDARTPFKIQLFSASIMVVMSFSASLLDAQYTVYALACIYPVHNILLTGISHYLVKRRLGYYGQKRILSVYARATFAAVFAAGVTAGVLWLLGGYSASGFAWASKISAIITLIVCGPVMLGSYMVGLRVFRVKEADALFAPITRKLGRLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWR7</accession>
    <name>A0A2Z5QWR7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86820">
        <property type="protein sequence ID" value="BAV86820"/>
        <property type="gene ID" value="RA11412_0521"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0521"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="33"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="185" mass="20654" checksum="ED41BF41A9D943E4" modified="2018-10-10" version="1">MSSRPSHLKPLSTQNSGQDYNPPGRGQTILLMAGIYIRAIYEVYVFALFCIVISLCLMGIGFVFLPFILNLMKFDAEAERNTARHRAGVEVIGGYKPVEDGKNPLSPARNLARLGDSLVLRDILWHFVNVFVGTFLGLYQHLYFSAACGALRLWWGSIISSLYLLLIPADHITWIPADHITCSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWV7</accession>
    <name>A0A2Z5QWV7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arginine/ornithine antiporter ArcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86871">
        <property type="protein sequence ID" value="BAV86871"/>
        <property type="gene ID" value="RA11412_0572"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0572"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="151" mass="16016" checksum="922C6AF564B2734E" modified="2018-10-10" version="1">MMTHSDNTPTSGAVSTEKEAEPDGTVTRYQSFALLGASILAAVATLGATMIAQRSLGSEQLKEFLLFWAALFMVTGIITGIQPEVTRAVGAARRDGVYRVRVVYVAGAFGALAGALVVCTAPCGRLSRFLSAPRGRWALSPPGCFFMRCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWX1</accession>
    <name>A0A2Z5QWX1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86928">
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        <property type="gene ID" value="RA11412_0629"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0629"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="289" mass="31398" checksum="DBC3E60784F756D5" modified="2018-10-10" version="1">MIELMPTSDNVTYSFKYVNGHPSNPARGYQTVTAFGLLADVDNGYPVFLAEMTLLTALRTAAVSAMVAKHLARKDSRKMAMVGTGSQSEFQALGMRAVLGIEDLAVYDVDPAAIEKFRRNLEPLGFRIHAASSVDEAVADADIITTCTADKQQAKVLLNSQVKPGVHLNAIGGDCPGKTELESEILDRSTVFVEFPPQTRIEGEIQQKDPDFPVVEFWKVLTGEEPGRVSDEQITLFDSVGFAIADFSGLRYARAATQGTDLQQFIDLVANPDDPKDLFSLVNVNVPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWX2</accession>
    <name>A0A2Z5QWX2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86816">
        <property type="protein sequence ID" value="BAV86816"/>
        <property type="gene ID" value="RA11412_0517"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0517"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="51" mass="5894" checksum="5AC9E9B3A2AA5653" modified="2018-10-10" version="1">MYVENMDPEAEDYLVSSIELLAENSLKVWLNSGDIVNVISHFKTGNYLFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWZ0</accession>
    <name>A0A2Z5QWZ0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor RpoE</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_05485</name>
        <name evidence="8" type="ORF">RA11412_0649</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86948">
        <property type="protein sequence ID" value="BAV86948"/>
        <property type="gene ID" value="RA11412_0649"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0649"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="215" mass="24413" checksum="71048C342CF22209" modified="2018-10-10" version="1">MTDEKRSDAGQSTGPPTEHVPHPNTASQGKDRYLVLRAQDGDIDAFGKLVERYQGRLFRTAYMIVRNRHDSEDIVQETLVQAWRSLHLLRDPDAFRGWLMRICTNKATSSIRQRQRRATDPYDSEGLESASILPDTTSTAAGDPAQSSEVNAQMEALAKLLASAPEELRIVWVLREVDDMSYEEISQTLNLTESTVRGRLARARSLVMRHMKEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX92</accession>
    <name>A0A2Z5QX92_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05495</name>
        <name evidence="2" type="ORF">RA11412_0647</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86946">
        <property type="protein sequence ID" value="BAV86946"/>
        <property type="gene ID" value="RA11412_0647"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0647"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="113" mass="11626" checksum="B1FEBDF7E5C1EC2C" modified="2018-10-10" version="1">MTINLSAAELTHVVTAVPGVRGIEPGIGSTLKAIGSRMSGDPAAARFGVIIESGGQKVIIEIGIDGSRAVKEIVRDVQEAVLRLLSQASREGGASGSGSKPQPQVRVRVQSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX93</accession>
    <name>A0A2Z5QX93_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">JCM 11412</strain>
        </source>
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            <dbReference type="EMBL" id="BAV87065.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
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</entry>
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</entry>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="BAV87175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87175">
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        <property type="gene ID" value="RA11412_0876"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="BAV87175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="89" mass="10393" checksum="D096EA0D6F2ACFE1" modified="2018-10-10" version="1">MIEASSRTHLEGHEKLMNAFTRDDFVASFNATLKNERVHRMVYLTKDKAVRDIASWIELRYNHVCLHSALGYRTPNEVERDFLDLKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXJ6</accession>
    <name>A0A2Z5QXJ6_9MICC</name>
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        <recommendedName>
            <fullName evidence="8">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I6I94_04555</name>
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    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
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        </lineage>
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    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transports L-lactate across the membrane. Can also transport D-lactate and glycolate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lactate permease family.</text>
    </comment>
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        <property type="protein sequence ID" value="BAV87162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT89872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87162">
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        <property type="gene ID" value="RA11412_0863"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="215"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="556"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="557" mass="58899" checksum="27DC5E894A253B53" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXN5</accession>
    <name>A0A2Z5QXN5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aliphatic sulfonate ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Alkanesulfonates-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_04885</name>
        <name evidence="6" type="ORF">RA11412_0787</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87086">
        <property type="protein sequence ID" value="BAV87086"/>
        <property type="gene ID" value="RA11412_0787"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0787"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340090" evidence="4">
        <location>
            <begin position="25"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="44"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="349" mass="37117" checksum="B0C9EE2A71F9D53C" modified="2018-10-10" version="1">MTAITRAEALKGLLAFSALTTVLAGCAGEGAGNPGAGSAKGKDTVTVDYATYNPLSLVIKKKGWLEKALQEKGKKLEWVKSAGSNKANEALRSGNIDVGSTAGSAALLARANGSPIKVIDLYSQPEWSALVTTKNSNIHAVSDLKGKSVAVTKGTDPYFLLLQALKQEGIAAKEVTIQNLQHADGRTALDNGQVNAWSGLDPIMASAEIESHDVLFYRNLDFNTYGFLNATEQFLTDNPDAAQTIVNVYEYARKWALENTAEATQILADESGIKLETAKLVMERTHLNIDPIPGDKQVQVLKGVGPILVESGDVPNQSDIDKALSSIVDDTYAKKADSAAVENVKKTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXN8</accession>
    <name>A0A2Z5QXN8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA uridine(34) hydroxylase</fullName>
            <ecNumber evidence="1">1.14.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA hydroxylation protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trhO</name>
        <name evidence="3" type="ORF">RA11412_0919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:64224"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:13381"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136877"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrhO family.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87218">
        <property type="protein sequence ID" value="BAV87218"/>
        <property type="gene ID" value="RA11412_0919"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0919"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00469">
        <property type="entry name" value="TrhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022111">
        <property type="entry name" value="Rhodanese_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268">
        <property type="entry name" value="PTHR43268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12368">
        <property type="entry name" value="Rhodanese_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="123"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="297" mass="33249" checksum="C28F60EFB8F9BDB0" modified="2018-10-10" version="1">MYYQFAPITDPVAVMLWQRALCEKLGLRGRILISKHGINGTLGGEISAVKAYTKETRQYPGFKNMEFKWSEGGAEDFPRLSVKARDEIVAFGAPDELTVDENGVVGGGVHLKPEEVNKLVEERGDEVVFFDGRNAFEAKIGKFKNAVVPDVRTTHDFIREIESGKYDDLKDKPVVTYCTGGIRCEILSALMKNRGFKEIYQIDGGIVRYGEKYGDKSLWEGSLYVFDKRMHMEFTPDTVTIGQCERCSAPSNKFENCSNESCRELVLLCPECATDDAKRRCVPECAVDRQSAHAGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXQ9</accession>
    <name>A0A2Z5QXQ9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87238">
        <property type="protein sequence ID" value="BAV87238"/>
        <property type="gene ID" value="RA11412_0939"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0939"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="3954" checksum="446C7472A81575C7" modified="2018-10-10" version="1">MPQGFTGPCVRGQVLMRLGRLVEALSTPLNLKTLAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXR6</accession>
    <name>A0A2Z5QXR6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lactate-responsive regulator LldR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_0862</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87161">
        <property type="protein sequence ID" value="BAV87161"/>
        <property type="gene ID" value="RA11412_0862"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0862"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="257" mass="29033" checksum="7CC45BE53E682F60" modified="2018-10-10" version="1">MQERSYSILLENFERRLRLGELRVGDRLPSERTLAEQYGISRPSVREALRILGALGLIRSSTGSGPKSGAIVISEPSDALSWALRMHIATRNLPVKDVVSTRLLLEGPAARAAANAPDSAERDLALENAREHLAEMDSPDISNERFHFCDTRFHYELSRLSGNIVLDTVIDSLHMATISYVQEAVPLLRDWATVKQTLQDQHRGIYEAISTRDEESAYERVCEHIKWFYSLSDRAREQQEWTGSHPASQVLHTNLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXS6</accession>
    <name>A0A2Z5QXS6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_04265</name>
        <name evidence="1" type="ORF">RA11412_0943</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87242">
        <property type="protein sequence ID" value="BAV87242"/>
        <property type="gene ID" value="RA11412_0943"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0943"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="562" mass="64221" checksum="83FE1602395C2FBD" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY41</accession>
    <name>A0A2Z5QY41_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87385">
        <property type="protein sequence ID" value="BAV87385"/>
        <property type="gene ID" value="RA11412_1086"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1086"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="135" mass="15455" checksum="6878F83D6C3E5A98" modified="2018-10-10" version="1">MSPFIWGRHRLGYCANDWTACTGLYLISRSAAQKIIEQIDARGSQYWLADDWPLFAADFGVDIKVMQPGLCDWTGNSLIEEDGTHFVYRKANQAKGQPLLNKLRIYAAPKARLKNAQNIVTSTLWQVRKKRRVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY48</accession>
    <name>A0A2Z5QY48_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87256">
        <property type="protein sequence ID" value="BAV87256"/>
        <property type="gene ID" value="RA11412_0957"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0957"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="321" mass="35151" checksum="F413DB8501A8393E" modified="2018-10-10" version="1">MVLPASVEADRLTRFTAAAAALQDAQVAARREAAEVLIGVADEWLADASVPRKQRLRQAQAAINALCMYIRSPFRLAKRYQRLTHGTVRRSWSAQKKRRLQASLEAFRAEAHLRGGILRAIAARLRTPDTVAPVSGGKTPQQHGGAPGSWSALTYDFSGAVFFYPVDFSGAYWGRRAVFEGCVFYGSADFSGGFFRRKARFAGCAWRGEVSFERCMFNRVADFSQGHYKGRLTGVFAPMLMRRGFTAQRIRIRLIIVAASTVGGPVLPITRTVLMRCLATASTAGMLCFRGPGTVAGRRWITAPMRGRRSCGSACMSGTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY60</accession>
    <name>A0A2Z5QY60_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">glmU</name>
        <name evidence="18" type="ORF">I6I94_03655</name>
        <name evidence="17" type="ORF">RA11412_1099</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87398">
        <property type="protein sequence ID" value="BAV87398"/>
        <property type="gene ID" value="RA11412_1099"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1099"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="16">
        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="19"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="15">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="268"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="15">
        <location>
            <begin position="402"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
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        <location>
            <position position="171"/>
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        <ligand>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57705"/>
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        <location>
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        <ligand>
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        <ligand>
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        <ligand>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
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</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
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                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">JCM 11412</strain>
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            <dbReference type="EMBL" id="BAV87270.1"/>
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</entry>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87224">
        <property type="protein sequence ID" value="BAV87224"/>
        <property type="gene ID" value="RA11412_0925"/>
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    <dbReference type="KEGG" id="raj:RA11412_0925"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="4505" checksum="3CC2F83ABD62E646" modified="2018-10-10" version="1">MLASVFAADCMIGTAYIYAFSGGAVNSGAVHILHPTSQQEHHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYB2</accession>
    <name>A0A2Z5QYB2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1001</name>
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    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87300">
        <property type="protein sequence ID" value="BAV87300"/>
        <property type="gene ID" value="RA11412_1001"/>
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    <dbReference type="KEGG" id="raj:RA11412_1001"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
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        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
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    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="566"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="656" mass="70987" checksum="BE59E2A8F8AAFBC4" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYC2</accession>
    <name>A0A2Z5QYC2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription-repair coupling factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_1153</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87452">
        <property type="protein sequence ID" value="BAV87452"/>
        <property type="gene ID" value="RA11412_1153"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1153"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="354" mass="39165" checksum="530D5534C3141692" modified="2018-10-10" version="1">MREGQVFFVHNRVANIDNVAAELAKLVPEARIATAHGRMSEARLEQIIVDFWERRFDVLVCTTIVETGLDISNANTLIVDNAQNYGLSQLHQLRGRVGRGRERAYAYFLYPPGKPLGEVALERLKAVATHNELGAGLQLAMKDLEIRGAGNLLGGEQSGHIAGVGFDLYLRLVGEAVADFRGEKDERDVEVKVDLPVNAHIPHSYIDAERLRLQAYRQIAAADTEQKMAEAREELTDRYGELPEPVQNLLAVTALRQRARAAGIREIVVMGPKVRVVTDEQLPDSRQMRLGRVYPGSSHTQPKGLQTWLTLLPRPKSSPVGGIELVDAAMLEWCQQLIDTIFADVPGASRSAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYD9</accession>
    <name>A0A2Z5QYD9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transport ATP-binding protein CydD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87485">
        <property type="protein sequence ID" value="BAV87485"/>
        <property type="gene ID" value="RA11412_1186"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1186"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="106" mass="11704" checksum="C43A2D7B8C4C4D8C" modified="2018-10-10" version="1">MLSDDLRSLSGGEKQRILLARMLLHERSFYIVDELTTGLDHATAGRVERALFESMEGFVYITHRTVPEVLAAVDEVLVMEDGELVASGTWDDVHAAALERGLVGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYE0</accession>
    <name>A0A2Z5QYE0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_03400</name>
        <name evidence="3" type="ORF">RA11412_1173</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87472">
        <property type="protein sequence ID" value="BAV87472"/>
        <property type="gene ID" value="RA11412_1173"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1173"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="94" mass="9963" checksum="1EB4F73CEB9DC1F0" modified="2018-10-10" version="1">MAYYAITYVYAAPEQQDAHRPAHRQYLAEQAESGPLVVSGPLMQDGSAAGALLIVNADSADAAEALVQEDPMNTGGAVLSYTVQEWNPVIGSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ35</accession>
    <name>A0A2Z5QZ35_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lspA</name>
        <name evidence="9" type="ORF">RA11412_1413</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase A8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87712">
        <property type="protein sequence ID" value="BAV87712"/>
        <property type="gene ID" value="RA11412_1413"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1413"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="235" mass="26063" checksum="715127916E33F04C" modified="2018-10-10" version="1">MKDEHTHAATTSKEQAAESGSGSTGSPRPHVISRRVFSTRSAWTLALLLAATVFIIDQGTKYLVVTRMEIGERTPVIEGLLWWYSIRNSGAAFSFGEGATWVFTLIMAVAAVVVVYTLRKTRALGWVLALGGLLGGVLGNLFDRLFREPGFGTGHVVDFISVPNFAIFNIADSAICVCMALIVLLNFRGMTLAGTRAESPQRTTPEHHTDDTPATWRKRHERYRAYARERRRHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ57</accession>
    <name>A0A2Z5QZ57_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87728">
        <property type="protein sequence ID" value="BAV87728"/>
        <property type="gene ID" value="RA11412_1429"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1429"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="47" mass="5426" checksum="1D856A7E5C371ACE" modified="2018-10-10" version="1">MDNLIYFDDVLNIRIHNSAFLSTYLVNNLGMFEAATQRLDGATERVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ79</accession>
    <name>A0A2Z5QZ79_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87676">
        <property type="protein sequence ID" value="BAV87676"/>
        <property type="gene ID" value="RA11412_1377"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1377"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="4"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="646" mass="70174" checksum="54459ACB143DE2DB" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ87</accession>
    <name>A0A2Z5QZ87_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2017 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87805">
        <property type="protein sequence ID" value="BAV87805"/>
        <property type="gene ID" value="RA11412_1506"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1506"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018561">
        <property type="entry name" value="DUF2017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09438">
        <property type="entry name" value="DUF2017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2017" evidence="1">
        <location>
            <begin position="10"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="202" mass="22916" checksum="678B6D7B16FDAC68" modified="2018-10-10" version="1">MARGFKNTPRGYTAYFEKPELLLIRDLAEDIVALLQPETGQDADPLDALIGITDNPQVPTDPAVSRLLPVGSSDEEAAAEYRRYTERDLRERKIANLSMLAFDIESADLLLDEEHARAWASALSDIRLVLATRLDITDDARAEEIHRYVDWSQIETEDEYLAMVYNFISWVQESLMSALMDGLHTPNPVHPGRCCSVMQRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZH3</accession>
    <name>A0A2Z5QZH3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nif3-like dinuclear metal center hexameric protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_01780</name>
        <name evidence="2" type="ORF">RA11412_1596</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87895">
        <property type="protein sequence ID" value="BAV87895"/>
        <property type="gene ID" value="RA11412_1596"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1596"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="298" mass="31218" checksum="20A2C5AE823A6A3B" modified="2018-10-10" version="1">MTETTTPNLAQVVAAFHDLYPPQLAAGWDASGLVCGRTAAPVRHVHFAVDALAATADEAVEHGAGLLITHHPLLLRGAQFIPDTDYKGHVLHTLIEGQCGLLGAHTNADAAIAGVNEALCDALHLTDRTALAESQTQELGGEEHLVGTGRVGTLSEPLTLRALSERLADALPATAGGLRIAGRPEQRVSRVALCGGAGDSLFEAVRSVGADVYITADLRHHPASEFREQELVRGTGCALIDCSHAASESLWLQRAGERLQALLAERGHSITFTVSSLNTDPWDFTVPTGSAAGSASTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZN8</accession>
    <name>A0A2Z5QZN8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xerC</name>
        <name evidence="14" type="ORF">I6I94_01670</name>
        <name evidence="13" type="ORF">RA11412_1619</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87918">
        <property type="protein sequence ID" value="BAV87918"/>
        <property type="gene ID" value="RA11412_1619"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1619"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
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    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="12">
        <location>
            <begin position="54"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="11">
        <location>
            <begin position="158"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
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            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV87918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT89371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="355" mass="39800" checksum="4C9BFD042350FCE8" modified="2018-10-10" version="1">MGSNQESPTGPDALRDSTTLLLTTRRLPHLLQTPGVAPGSPVPGASAPTLEVYRPHLQQFERYLRYEKHRSEQTVRSYISDLEGFLGFAARRGVSTLEAIDITLIREWLGAMHLRQNSKATVARRGSTLRTFFTWAQDEELIIDNPTRGMSTPKRDRHLPSVLSQAQMNQLLDELQQRHRQTPTDARLLRLWAVVEVLYASGMRISELTGLDLNSVDRANRTVRVLGKGNKERIVPLGVPAMKALNRWVAHGRPQWIPEGSRNVTALFIGPRGRRANPRQVREDLSRLLRTLENSEASGAHVLRHSAATHLVDGGADIRTVQELLGHSSLATTQIYTHVSMKRLAETYARAHPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZP0</accession>
    <name>A0A2Z5QZP0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TsaC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87761">
        <property type="protein sequence ID" value="BAV87761"/>
        <property type="gene ID" value="RA11412_1462"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1462"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="147" mass="15737" checksum="7EAF0595D750E852" modified="2018-10-10" version="1">MVVREGAISVEALREVVPSIVTRAELDERNELKAKERAAEGETHAAAGQEDLDEAYEQWDKEHSQGSESARRAGAPAEGSIASALMGAVGVLGEVSASAGIDQQRTRQYRNNTPTPVKRDEAQAQPFSAQQARALVFGEQTESASTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZP3</accession>
    <name>A0A2Z5QZP3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-protecting protein DprA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Rossmann fold nucleotide-binding protein Smf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dprA</name>
        <name evidence="4" type="ORF">I6I94_01675</name>
        <name evidence="3" type="ORF">RA11412_1618</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87917">
        <property type="protein sequence ID" value="BAV87917"/>
        <property type="gene ID" value="RA11412_1618"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1618"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="517" mass="56420" checksum="577DC78138DE464F" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZR2</accession>
    <name>A0A2Z5QZR2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diaminopimelate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87750">
        <property type="protein sequence ID" value="BAV87750"/>
        <property type="gene ID" value="RA11412_1451"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1451"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="1">
        <location>
            <begin position="159"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="265" mass="28135" checksum="B9C1D690DC60D60B" modified="2018-10-10" version="1">MCTAVARWAHEEGLCLDTASGGELAIALRAQVPGQDIALHGNNKSYDEIKRAIKHGVGRVVVDSIDELKLITDVYAELCAESVAEGLEPYPAVPVLIRITPGVHASTHESIATAHEDQKFGMSLQPGTARLAGLEADELEYWSTTEDESYAMLAAGILAVTDSLEFRGIHCHIGSQIFEAQGFEQAADTALTFMHAVNQKYGLSLPELDLGGGYGIGYTEADTPRSIEQITVSIADAVAATCVRLGLAIPHMSFEPGRSISGPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZS2</accession>
    <name>A0A2Z5QZS2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87947">
        <property type="protein sequence ID" value="BAV87947"/>
        <property type="gene ID" value="RA11412_1648"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1648"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001826">
        <property type="entry name" value="RHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03527">
        <property type="entry name" value="RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00394">
        <property type="entry name" value="RHSPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="147" mass="17373" checksum="4D12017A141A7D77" modified="2018-10-10" version="1">MQEIQPDGRYTYIYADQDSYEPLAQVQDLTTEDGESCQQTHYFHCDQIGIPREMTDKDGKLLWFGNYTGWGRLKEETKVTDSAYQPFRLQNQYADRETGLHYNFFRYYEPDAGRFVNQDPIGLEGGKNFYSYSSNTTKWIDIHRIMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZV2</accession>
    <name>A0A2Z5QZV2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA or RNA helicase of superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87790">
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        <property type="gene ID" value="RA11412_1491"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1491"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="559" mass="61288" checksum="308D39DF561E8785" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZW2</accession>
    <name>A0A2Z5QZW2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I restriction-modification system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="162565">
        <property type="entry name" value="Rae11412ORF1692P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87987">
        <property type="protein sequence ID" value="BAV87987"/>
        <property type="gene ID" value="RA11412_1688"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1688"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025285">
        <property type="entry name" value="DUF4145"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13643">
        <property type="entry name" value="DUF4145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4145" evidence="1">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="129" mass="14680" checksum="2B77DA22318A2E1C" modified="2018-10-10" version="1">MSNFDFLTVSIPEVHQNALKAESALRIDAPMAAIYSRITLEQLIDYLYRVRSIPLPYGKVDATLNERLRNPEFLRLITVPALTTKMHLIRRIGNDAAHGKRITPQAAAQAVLDLHHLLIWAVRYHCPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZY7</accession>
    <name>A0A2Z5QZY7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6493 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88017">
        <property type="protein sequence ID" value="BAV88017"/>
        <property type="gene ID" value="RA11412_1718"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1718"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="36"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="285" mass="31387" checksum="96A59568ECF696F4" modified="2018-10-10" version="1">MVVVPLPARKDISWARSEQRVCWEEKDATPKTPETPFEQAALNTHGTVEEYLDRSGDGESWNIWNDEVVRWYAWLTQNNPDVLAVQFLPLAFGAVYQPQQIGLPSLLQALGHSHRVLGAPSYTVIGQAMGAQRREYRTIAAEAIALLAERGMLDTAAFSAELSWLLTQKHLMTNRAVETLTDAASISPLTGWRVLQILAEILPVAGEVNRGGSLVQLAGQLAEEYGVTIEIPEVLRPKMKGSTVLAKSLRVLDTLQPHPTELAEQARNQAREIVTKNGAGHAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZZ6</accession>
    <name>A0A2Z5QZZ6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6493 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88027">
        <property type="protein sequence ID" value="BAV88027"/>
        <property type="gene ID" value="RA11412_1728"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1728"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="27"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="151" mass="15936" checksum="A1D138670308A9E9" modified="2018-10-10" version="1">MQNNLDYAAAQMMPALVTALYTRTVFGLNALLYALGSTPCPLGAPSYSALGIAASALAQDIRALTAESLAHLAERGMLDPAQFAEEVTWLLLHQDVLTNRVLGTLQDAASISPLAGWRIVQVLENMLPAVSDINRGGSFVQLLVQLAGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R023</accession>
    <name>A0A2Z5R023_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87973">
        <property type="protein sequence ID" value="BAV87973"/>
        <property type="gene ID" value="RA11412_1674"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1674"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="163" mass="17525" checksum="A81C83A3219EA744" modified="2018-10-10" version="1">MASPASNGPAVINGKEYWISQTTALGDEKAVITLTTSYLASDDGEGELKPGCKYTFRYFVVASDTNHGGRKGDVKLDIQLRNPSGVLVRNTGHSYTTKSGQNTNKTTSVPFNTEVAARGVNFTAREGLYHLEITITVAAEGNRREKVAARGIGITSPYFEFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R045</accession>
    <name>A0A2Z5R045_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane alanine aminopeptidase N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88087">
        <property type="protein sequence ID" value="BAV88087"/>
        <property type="gene ID" value="RA11412_1788"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1788"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERAP1_C" evidence="2">
        <location>
            <begin position="2"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="295" mass="31701" checksum="E562915CA558CA70" modified="2018-10-10" version="1">MRDARLPVSTFVDAVVRNVSLEPSASLLGSMVSHAQAAVANYASQTERENLYNALHDAFSTALAAASPGSDAQLILLRALITVSGVATQGEETCRDIARGAFEDTTGDIAVATGIPYDQNLGWAALGALAERNLVSVTELEQAARYNPSSISANGYAYALAALPQAEHKAEAYRTVMEDSTLSNDALSSTANGFRLGPDELREPYFESYFAALSDIWESRSIGMATRIVRGLYPRISYGHGSAAGLDVDDTAPVALAERWLQEHPEAPSALRRLILEAQDLTRRNLNAQKFNATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R084</accession>
    <name>A0A2Z5R084_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exoenzymes regulatory protein AepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88127">
        <property type="protein sequence ID" value="BAV88127"/>
        <property type="gene ID" value="RA11412_1828"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1828"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4632" checksum="D932FD02862EC113" modified="2018-10-10" version="1">MVQAPDSRVASWSTDPRARIPLLPALDVPLPTLERLYTQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R087</accession>
    <name>A0A2Z5R087_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="15">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 20" type="primary">carB</name>
        <name evidence="20" type="ORF">I6I94_00605</name>
        <name evidence="19" type="ORF">RA11412_1876</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="15">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="15"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88175">
        <property type="protein sequence ID" value="BAV88175"/>
        <property type="gene ID" value="RA11412_1876"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1876"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 15" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 20" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="133"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="680"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="18">
        <location>
            <begin position="953"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="15">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="15">
        <location>
            <begin position="953"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="830"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="842"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="844"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="BAV88175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QQT89174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="1112" mass="120081" checksum="CB4188676F356698" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0A4</accession>
    <name>A0A2Z5R0A4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase AdhP</fullName>
            <ecNumber evidence="5">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">adhP</name>
        <name evidence="5" type="ORF">I6I94_01420</name>
        <name evidence="4" type="ORF">RA11412_1651</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87950">
        <property type="protein sequence ID" value="BAV87950"/>
        <property type="gene ID" value="RA11412_1651"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1651"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="12"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="342" mass="35724" checksum="BF0F048E057FA1AE" modified="2018-10-10" version="1">MKAVVVPEHIDGSVVVTDVPVPEVGYGQALVKLEYSGVCHTDLHVAAGDFGKVPGRILGHEGIGIVTEVGEGVESLKPGDRVSIAWFFQGCGHCEYCTSGRETLCRTVKNAGYTVDGAMSEYALVTADYAVKVPEGLDAAQASSITCAGVTTYKATKESQVRPGQWLVAYGAGGLGNLAVQYAKKVFGAKVIAVDINDDKLKFAAETGADVTINGREVEDVPAKIREVTGGGAQAAVVTAVSKVAFNQAVESVRAGGSVVAVGLPPEKMELSIAKIVLDGIRVLGSLVGTRQDLAEAFQFGADGLVVPLVQLRKVEEAPQVFEEMGAGKITGRMVLDFASIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0F8</accession>
    <name>A0A2Z5R0F8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FtsH protease regulator HflK</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative stomatin/prohibitin-family membrane protease subunit YbbK</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">SPFH/Band 7/PHB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">qmcA_2</name>
        <name evidence="3" type="ORF">I6I94_00835</name>
        <name evidence="4" type="ORF">NCTC10207_01140</name>
        <name evidence="2" type="ORF">RA11412_1814</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88113">
        <property type="protein sequence ID" value="BAV88113"/>
        <property type="gene ID" value="RA11412_1814"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1814"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI23043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="329" mass="36202" checksum="D96169BE02E39333" modified="2018-10-10" version="1">MFNILTIIGIALVIFVVIALIRTIRVIPQARAGIVERLGRYHTTFHPGLHIVIPFLDRLLPLIDLREQVVSFPAQSVITEDNLVVGIDTVVYFQVTDPKAATYEITNYIRAVDELTSATLRNVVGGLNLEQALTSRDQINTELRGVLDSTTGRWGLRISRVDIKEIQPPHSIQDSMEKQMRAERDRRAAILTAEGKKQSDILTAEGESRAAILRAEGEKQAQILRAEGDAQSTVLRADGEADAVRKVFEAIHQSNPSQQLLTYQYLQTLPKLADGQANKLWFIPTELGDALRGLGNAFGTLPVSDLKDAPVNITKPKHAGDDLNGGSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0G6</accession>
    <name>A0A2Z5R0G6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6493 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88020">
        <property type="protein sequence ID" value="BAV88020"/>
        <property type="gene ID" value="RA11412_1721"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1721"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="13"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="207" mass="22577" checksum="BAA53522665B0ED4" modified="2018-10-10" version="1">MQFPLWVGTDTPDAAALSVESAAFNTNSTQIEYVHRMLESKYYPSYRTVMGWYGWLMQNNPDIFSAQTMPILVAAIHAHNAYGVDIIIRILGDTHRILGAVSYSALGLGASAKTTEVRANAAEALASLADRGMVDTALFAEELCWLLSQHHVKAQRIEQTFRDAASISPLVGWRIMQLLEGILPVVGEVYRGGALVQLLVQLAGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0H4</accession>
    <name>A0A2Z5R0H4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88133">
        <property type="protein sequence ID" value="BAV88133"/>
        <property type="gene ID" value="RA11412_1834"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1834"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="38" mass="4458" checksum="8BEB9B25951FE353" modified="2018-10-10" version="1">MPWWFWVLLWGALSITALLFLAFLGYRALVRGLLSLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0I4</accession>
    <name>A0A2Z5R0I4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylaminoimidazolesuccinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86369">
        <property type="protein sequence ID" value="BAV86369"/>
        <property type="gene ID" value="RA11412_0070"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0070"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
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    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="8">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="107" mass="11979" checksum="2294B11DF3E8052C" modified="2018-10-10" version="1">MTSRTAPIEIPGWTHVYSGKVRDLYVPEESRYDAAGLTISDDAEVRAGSVMVVASDRISAFDKILPTEIPDKGAVLTQLSLWWFKQLGTCQTTCFPRTCRTKWRGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0J7</accession>
    <name>A0A2Z5R0J7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitric-oxide reductase</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">RA11412_1697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87996">
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        <property type="gene ID" value="RA11412_1697"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1697"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
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            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAV87996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="432" mass="48888" checksum="6256827367D93AE9" modified="2018-10-10" version="1">MLTVILFVAVVFVVLGSLLNEWLSQKGWVPENSIFSQQWEYLDLPRFFQILLTAGMFIWIVIVWRTLSSRLKTGKKTSMPWLFLFSGLAIPMFYAVGMLAGQRTHFSVAEFWRFWVVHLWVEDFLELFTTVMVAYIFVLLGVVRERIAISIIMMDAVLYSAGGVVGTMHHTYFAGTPSEQMAFGAFFSAAEVIPLTFLTVEAWGFMQLGARQYSNRTKPFPHRWAVMFLIAVGFWNFLGAGVFGFLINLPIVSYFEIGTALTANHAHGSMMGVYGMLALAFAVFALRYLIPENKWPEKGVKFSFWALNIGLIWMVFISLLPLGVAQLYHSVGQGYYEARSLAYIQSDANLIMDWLRMPGDVIFLAGILPLIKLAWLGITSYFAPKNKETVLELPEPPLYEMVDDARIAEFAGAKAADELPEQTSPYRSDRRG</sequence>
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<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0M4</accession>
    <name>A0A2Z5R0M4_9MICC</name>
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    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="1 2" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88090">
        <property type="protein sequence ID" value="BAV88090"/>
        <property type="gene ID" value="RA11412_1791"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1791"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="220" mass="24888" checksum="EA041CE397576113" modified="2018-10-10" version="1">MQHIFTLHLPEPYRRRGPEYVAVSFFAGDSWEIIQEIPPLLLKEHSDTPLTTQLRQYQPHPMFQELHDSLDGVFGLLYLTREEFSARSNGPTNPYREGEQFIVLPLRQRTRLFTQWGAAHPTQALGLVYRPDPNAGVPPADDGVNGYEDPWDEETGDFRNWADPLFSKCHLGGTALPGQFLPSGLSAYYLEITEMGVLEFGDCGSAQIDLDNNVFDWTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0M7</accession>
    <name>A0A2Z5R0M7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4190 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00165</name>
        <name evidence="2" type="ORF">RA11412_1989</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887292.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88288">
        <property type="protein sequence ID" value="BAV88288"/>
        <property type="gene ID" value="RA11412_1989"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1989"/>
    <dbReference type="Proteomes" id="UP000250241">
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    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="143" mass="15155" checksum="B3335E04D0CA1479" modified="2018-10-10" version="1">MSNKTVPLTEAYSAYTQPLEPQILEEIPKKKWAAITALVLSLIAFFTGILVIGFVPAIFAIVFAGIALGQVKKGEAEGAGMAIGAIIFASLAIIASVGIVILALISNYYTEQQVIDGCTSGKGTYTVENGQKVCHYMGYAMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0W6</accession>
    <name>A0A2Z5R0W6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monoamine/putrescine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88124">
        <property type="protein sequence ID" value="BAV88124"/>
        <property type="gene ID" value="RA11412_1825"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1825"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="460" mass="50456" checksum="38BBA1150085343F" modified="2018-10-10" version="1">MIPKDATTTELTRDVAIIGAGPSGLTAAYRLQQAGHTVAVIEARERVGGRTWSNHINGAFLEIGGQWVSPDQTALISLISELGLKTFSRYRDGENLYRDPNGTMHRYTGDMFPANEKTQQEMVRLIEKLDALAAEIGAQQPWAHPKARELDTISFHHWLRTQSDDEEACNNIGLFIAGGMLTKPAHAFSALQAVLMAASAGSFSNLVDEDFILDKRVVGGMQSVSLTLAQKVGAENIILGHPARVLRWQEPGEYPVRVEAEAFSEDGVASPADNVIVRAKYVVVAVPPNLYSRVHFVPALDRRQHQMHQHQSLGLVIKVHAVYPTPFWRDKGLSGTCFAANNLVQEIYDNTNYDPQTDQEESRGTLVGFVSDEAADKMFTISAEERKARILDSMAQMLGRKRKTPSCTTNLTGAPRSGPAGHMLLATIWVVCTGMVLISSPRLGRFTGHALILLLMATSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0X9</accession>
    <name>A0A2Z5R0X9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88156">
        <property type="protein sequence ID" value="BAV88156"/>
        <property type="gene ID" value="RA11412_1857"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1857"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="101" mass="10821" checksum="CED624A88450BC87" modified="2018-10-10" version="1">MSALIRLDARLIPAVAALWVFTAFALLGGTFETVKVAAVLCIAALAVAVGALYLPEGGGISVAECPGHSGVQRTGVRRVWRSARPYVVFMGVWVRGRLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Y5</accession>
    <name>A0A2Z5R0Y5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88332">
        <property type="protein sequence ID" value="BAV88332"/>
        <property type="gene ID" value="RA11412_2033"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2033"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="92" mass="10283" checksum="373DE9AA00080670" modified="2018-10-10" version="1">MTEALRLEEADNNLRVIEIRPGMVHTEEFSLNRLGSAEMAAKVYEGVEKPLVAEDVAQTVVFALNVPHHVNLDCITLRPVAQASQFKVIRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R190</accession>
    <name>A0A2Z5R190_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fumarylacetoacetate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88254">
        <property type="protein sequence ID" value="BAV88254"/>
        <property type="gene ID" value="RA11412_1955"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1955"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="146" mass="15862" checksum="856DADE684552D18" modified="2018-10-10" version="1">MSGVSEEQALEGLLGYTVTNDVSVRDWQGRTSQWFQGKNWDRMTPFGPVIVTPDEVDPAAGLAMSCEVDGEIRQSGTTADMVFTPAQLLSYLSTFMTLEPGDVILTGTPAGVGLSYHPRRWLKPGQTLVTRIEGIGKLVNTCSQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R191</accession>
    <name>A0A2Z5R191_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HlyC/CorC family transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein Rv1841c/MT1889</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I6I94_10440</name>
        <name evidence="11" type="ORF">RA11412_2256</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037234948.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88555">
        <property type="protein sequence ID" value="BAV88555"/>
        <property type="gene ID" value="RA11412_2256"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2256"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="221"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="285"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV88555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT88919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="360" mass="38839" checksum="206893CAA670CC32" modified="2018-10-10" version="1">MNDWIAIGLLVFLLAGNAFFVAAEFAIMSTRRAQIEPLAENGSLRAKKVLYALENVSLMLATCQLGITICSLLILNVSEPALHHLLEHPLAATGIPPVAVDVAAFSLTLILVTYLHVIFGEMVPKNAAVTLAARGIALWIVPSLMRVARIFAPVVALLNGMSNRVLAWVRVEPKDEVASTFTLGELQSIVAQSTAEGTVEDDAGVIGGALEFTEKSVSEIMVPREQVQTLTLGCTPAELEHAVARTGYSRFIVTDPEGSYMGYLHLKDALAVPPAREHIPFGWRLVRSMSVVAPETDIDDALAIMQGNNSHLAHVVGSNGRSLGVVFMEDVLEELVGEIKDTTQDRVRRLQAASRASNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1A3</accession>
    <name>A0A2Z5R1A3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DipZ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_2159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88458">
        <property type="protein sequence ID" value="BAV88458"/>
        <property type="gene ID" value="RA11412_2159"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2159"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041017">
        <property type="entry name" value="Thioredoxin_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17991">
        <property type="entry name" value="Thioredoxin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="301"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="615" mass="66232" checksum="908C0E95117E794D" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1D3</accession>
    <name>A0A2Z5R1D3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nudix-related transcriptional regulator NrtR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86699">
        <property type="protein sequence ID" value="BAV86699"/>
        <property type="gene ID" value="RA11412_0400"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0400"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="271" mass="30433" checksum="03F3E0FCDE305E44" modified="2018-10-10" version="1">MSISPDSTPAVELYDDHTEGDHSSVSLAVSTVILALRPKEGQQHPSLWLPLVRRLREPYKGQWALPGGPLQSQQSLEQAAGYTLKRATGLEPGYLEQLYAFGDVLRAPEARAARINGAPVPVPGADHERVVSVVYWASIPATEVSQTRVHENIRWFPVDELPELAFDHNEIVEYALYRLQNKVEYSRIAHSFLGKSSLWRSCVRCTRRFLAVRWIPRISAARLQPQNRLLIPAGALKVPATARRACTVTTRLRLMRMRAHWACTASATNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1H4</accession>
    <name>A0A2Z5R1H4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">ffh</name>
        <name evidence="11" type="ORF">I6I94_11170</name>
        <name evidence="12" type="ORF">NCTC10207_01346</name>
        <name evidence="10" type="ORF">RA11412_2067</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887981.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88366">
        <property type="protein sequence ID" value="BAV88366"/>
        <property type="gene ID" value="RA11412_2067"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2067"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="9">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="444"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="478"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="198"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="256"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VEI23246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="526" mass="57010" checksum="D4CDA357B19C1AA4" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1I7</accession>
    <name>A0A2Z5R1I7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimM</name>
        <name evidence="4" type="ORF">RA11412_2062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88361">
        <property type="protein sequence ID" value="BAV88361"/>
        <property type="gene ID" value="RA11412_2062"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2062"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="3">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="195" mass="21411" checksum="6C0521EF5C214023" modified="2018-10-10" version="1">MQVLVARIGKPHGIRGEVTVELFTDAPEERFSRGEVLHIDGFTHGTVAATVAPAGALTVASARWNKKILVVRFEEITTRNHAEDLRNTLLMFEVPEDVNSEEEGFYEHQLLELPVFLLEDVPEGEIPNDNPAVGEPLGTVIGLQTMPVQDLLLVKLSPAYGGQEIMVPFVDEIVPEVVPAEGDEPGFVLLSPRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1P9</accession>
    <name>A0A2Z5R1P9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88618">
        <property type="protein sequence ID" value="BAV88618"/>
        <property type="gene ID" value="RA11412_2319"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2319"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="49" mass="5212" checksum="FBC4F53B851E4454" modified="2018-10-10" version="1">MANTKAAMSAATITKVQPSGPNRRLRPARFGCAEAEAVTIPSQYGLKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1R7</accession>
    <name>A0A2Z5R1R7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88623">
        <property type="protein sequence ID" value="BAV88623"/>
        <property type="gene ID" value="RA11412_2324"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2324"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="90" mass="10155" checksum="85BC65DA8C3470E4" modified="2018-10-10" version="1">MGVEPAYPLGFCHPGAGRIRISDALTGAPEYVVDAVLYHELCHFVVLHHNAQFHRLQDRLPRLAQAQAFLAGIEFARTQEAHERRPEDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R274</accession>
    <name>A0A2Z5R274_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rplX</name>
        <name evidence="7" type="ORF">I6I94_09160</name>
        <name evidence="8" type="ORF">NCTC10207_01769</name>
        <name evidence="6" type="ORF">RA11412_2556</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888716.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88855">
        <property type="protein sequence ID" value="BAV88855"/>
        <property type="gene ID" value="RA11412_2556"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2556"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI23851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="111" mass="11925" checksum="3C71F87179D1E9ED" modified="2018-10-10" version="1">MAKIKSGDLVQVISGADKGKQGKVLKVIPKENRVIVEGVKVVTKHTKANPVTGAAGGIQKVEAPIHVSNVAIVDPETKKPTRVGFREETVERNGKTRTVRVRYAKSSGKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R277</accession>
    <name>A0A2Z5R277_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mscL</name>
        <name evidence="10" type="ORF">RA11412_2529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MscL family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88828">
        <property type="protein sequence ID" value="BAV88828"/>
        <property type="gene ID" value="RA11412_2529"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2529"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="128" mass="14083" checksum="A4E23B31C1F7E08D" modified="2018-10-10" version="1">MVILNHMLKGFKDFILRGNVLDLAVAFIMGAAFNEVVKALVNSILMPAISMVVGVQNYDNFLAFGDVKVGVFLTAVVNFLLVAAALYFAVVMPMKKLNARVSKKKAEDMEDTELSLLKEIRDSLATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R290</accession>
    <name>A0A2Z5R290_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88877">
        <property type="protein sequence ID" value="BAV88877"/>
        <property type="gene ID" value="RA11412_2578"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2578"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFG_IV" evidence="2">
        <location>
            <begin position="73"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="219" mass="24108" checksum="24711FD7A81B8942" modified="2018-10-10" version="1">MIFVAIEPKTKGDQEKMSTAIQKLSAEDPTFTVSLNEETGQTEIGGMGELHLDIIVDRMKREFKVEANVGKPQVAYRETIKKAVEKVDYTHKKQTGGSGQFAKVQVSFEPLPLDGEELYEFEDKVTGGRVPREYIPSVDAGIQDAMKFGILAGYPMVGVKATLIDGAYHDVDSSEMAFKIAGSMVFKEGAKRANPVLLEPLMDVEVRTPRSTWAMLSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2B5</accession>
    <name>A0A2Z5R2B5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_10155</name>
        <name evidence="1" type="ORF">RA11412_2317</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88616">
        <property type="protein sequence ID" value="BAV88616"/>
        <property type="gene ID" value="RA11412_2317"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2317"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="79" mass="8593" checksum="0F80DE67CDAC7B46" modified="2018-10-10" version="1">MRWAHVIRSFAQEFIADSGIDSSQVWTMGYSGGAEFITNELNASRRNSWRTGGGSIMVGGGGAEKRIEAPDSIKPIPMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2F8</accession>
    <name>A0A2Z5R2F8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="1">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88908">
        <property type="protein sequence ID" value="BAV88908"/>
        <property type="gene ID" value="RA11412_2609"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2609"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="1" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="16"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="231" mass="24179" checksum="81D9839F295DC1D9" modified="2018-10-10" version="1">MNGFDEIPVLAPVTARCAFTGNEVITIGVPEAGQVRDAFGGFLEATLATQGCAALPSARLADTGHDFTTFLNTSHAQVLIFTGGSSTSGVDMVRKTLAEAQATYLFESVQVRPGHPALAARLADGRIVLGLPGNPLAAYTALYSYLPPLLAGMRGLPLPPLDTAEIAQDIPALTASSQQRLIPALVRECRAHPLPRRASYMLSGLSKATHLLVADASGHTAGDRVPLLPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2G1</accession>
    <name>A0A2Z5R2G1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88792">
        <property type="protein sequence ID" value="BAV88792"/>
        <property type="gene ID" value="RA11412_2493"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2493"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016369367" evidence="2">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="111" mass="11754" checksum="79F6CF19E578ACBC" modified="2018-10-10" version="1">MILPCTLLWSFTVLFAPAAPATAQLVSTGETITEQLGTSNQLSLWVLLGVPFLLVSLALVLNFGLGPYSLYFMRETAVATRIKTLLLGLPFTLAVGSLIAWLMADGAALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2I0</accession>
    <name>A0A2Z5R2I0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal-protein-S18p-alanine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88812">
        <property type="protein sequence ID" value="BAV88812"/>
        <property type="gene ID" value="RA11412_2513"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2513"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="168" mass="18670" checksum="56650506D5C8DA4B" modified="2018-10-10" version="1">MPDLHTLETRLFPADAWALDMFLAEVGHPTRSYYVLEHDTGSGPSIIGYCGVMVVGDTADVQTIAVLPEHEGNGYGRAMLETMHTRSRQQGAERILLEVRADNPRAQRLYRRNGYTRIHVRPRYYDDGTDALIMLKELTAPTAPVATVHPPATGEHPTAPHTAKDRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Q2</accession>
    <name>A0A2Z5R2Q2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tsaE</name>
        <name evidence="7" type="ORF">I6I94_09325</name>
        <name evidence="6" type="ORF">RA11412_2515</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037234601.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88814">
        <property type="protein sequence ID" value="BAV88814"/>
        <property type="gene ID" value="RA11412_2515"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2515"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="197" mass="21561" checksum="D24428E9475B5696" modified="2018-10-10" version="1">MYAAEAIDLEVTDPAHTRRLAHALARMLRAGDVLLLSGELGAGKTTFTRSLGEGLGVREGVISPTFVLSRVHPSLPDGPRAGGPDLVHVDAYRLSSAEELDDLDLEFSLDTSVTVIEWGRGKAEHLSDSRLELDFTRLHGAHTALEYAAGEQGEFDWDAQDDADTDTPEARLLRVRAIGPRWEGHAAHELYRALQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2T5</accession>
    <name>A0A2Z5R2T5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xseA</name>
        <name evidence="10" type="ORF">I6I94_09560</name>
        <name evidence="9" type="ORF">RA11412_2462</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88761">
        <property type="protein sequence ID" value="BAV88761"/>
        <property type="gene ID" value="RA11412_2462"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2462"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="39"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="150"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="349"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT88757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="431" mass="46483" checksum="E4FDA3F71A407AE5" modified="2018-10-10" version="1">MSNFDARPQVLAVPPAHERQIPATSSETSAVNPWPLALLARNLKAHIEKVPQLWVEAQVISLNNRRGSVFIDLKDLEADATFSLALFGRAAYSIGKDVVPGARVVVLAKPSFWVPSGRLSLVGERIHAVGTGNLHERLQQLREALAAEGLFADSRKKPLPLLPQKVGLVTGRDSDAMKDVIRNASLRWPGVVFEVRQVAVQGANAVREVCAALSELDADPLVDVIVLARGGGSFEDLLPFSDESLVRAVAAAHTPVVSAIGHEADSPIVDAVADVRASTPTDAGKRIVPDVAEEFARISEARGRIDRAIAGYLSNQWQYVQQLRQRPVFTSPENDLGWRADDVHRLRERALVSVQHRLAREQDAVAHTLARVRSLSPELTLRRGYAIVQRADGALVRDASALTVGEKLTVRAGVGSADASVTGVHASNVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2U0</accession>
    <name>A0A2Z5R2U0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6318 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_2714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89013">
        <property type="protein sequence ID" value="BAV89013"/>
        <property type="gene ID" value="RA11412_2714"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2714"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046281">
        <property type="entry name" value="DUF6318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19843">
        <property type="entry name" value="DUF6318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016303081" description="DUF6318 domain-containing protein" evidence="2">
        <location>
            <begin position="38"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6318" evidence="3">
        <location>
            <begin position="99"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV89013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="207" mass="21481" checksum="A17CB80EC4C645BD" modified="2018-10-10" version="1">MMVEPNTGRIVPRRRALLLAGVGLGSLGLAACGGAGNAEGQSGSSSSVSSDGGVSGSEAEASVSDSPSSSVSEGPSAAPSSGGETIVKGYSGGSKAPEGEYRAADEHGPAQNVPKPKEPAGMNVETVEGVVKFLNYWVAAHNYSIQTGDAVPWANTTSKADEHDTKSIQWVHDLYHNNEGWIAGGLRNITIHEETFHKSDKEKSIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2X9</accession>
    <name>A0A2Z5R2X9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89053">
        <property type="protein sequence ID" value="BAV89053"/>
        <property type="gene ID" value="RA11412_2754"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2754"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="79" mass="8520" checksum="C871FF017E46B922" modified="2018-10-10" version="1">MAFMNRCSPAEVSDPHQPSVEMALAEVAVTRVEPKAARPAAGTPIAPALRSLRRESLVFSKVIISSFSYVEAYKADIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R309</accession>
    <name>A0A2Z5R309_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA:Cys-GlcN-Ins acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88934">
        <property type="protein sequence ID" value="BAV88934"/>
        <property type="gene ID" value="RA11412_2635"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2635"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="272" mass="29795" checksum="53B35C78ABC85243" modified="2018-10-10" version="1">MAPEQFTPEAVSFTQPVLSDEFLARFDDFAATVQAHDGTPAFSEQTRIELSKALATHDAVPPRVFVLERAGYLAAALVAVPASGGQQDTVPGVIEAAVHPDARGVHLGQEFFELAIAELGAEASLYNLWVHGSAQDTGIESPANALAKAEGFKPVRVLYKMVLPLDPQTRENLVEASDARQLPDDLLLRTYTRDDEQPWLRVNAQAFAHHPEQGRLTLADLRERTGADWFRPKGSSLPATVKTPAASPHSRGRKYRALSPPRHCHRPVKSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R329</accession>
    <name>A0A2Z5R329_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_08345</name>
        <name evidence="1" type="ORF">RA11412_2753</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT88533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="RA11412_2753"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2753"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="171" mass="18465" checksum="DA3EBFEA5E17DB08" modified="2018-10-10" version="1">MTNEHTGFSRRKLLKAGAIGVPAAGVLAFGSTLVTATSANAISTDGWWGSETSAGLQRFLNTVVTNKGWLTSEEFSKGLVVDGIISSQDSGMVRQCPAIVGGWEWVESGKAEGSPTIKWLQSWLDLNPPTPIFGTGDIFYLQRHYGIPQDGRLDGPSRTVQALQNEINQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3A2</accession>
    <name>A0A2Z5R3A2_9MICC</name>
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        <recommendedName>
            <fullName evidence="2">Fibrinogen C-terminal domain-containing protein</fullName>
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        <name evidence="3" type="ORF">RA11412_1150</name>
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    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016435910" description="Fibrinogen C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="37"/>
            <end position="703"/>
        </location>
    </feature>
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        <location>
            <begin position="43"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="703" mass="76664" checksum="E833B4CEF19D320D" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3D2</accession>
    <name>A0A2Z5R3D2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">frr</name>
        <name evidence="6" type="ORF">I6I94_03195</name>
        <name evidence="7" type="ORF">NCTC10207_00637</name>
        <name evidence="5" type="ORF">RA11412_1220</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT89630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006889026.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87519">
        <property type="protein sequence ID" value="BAV87519"/>
        <property type="gene ID" value="RA11412_1220"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1220"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
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        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
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    <dbReference type="PANTHER" id="PTHR20982">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VEI22556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="185" mass="20585" checksum="81612EA14D91C200" modified="2018-10-10" version="1">MIEETLAEAGEKMDKTVEAAKAEFAKVRTGRVNPGLFSSLTADYYGAPTPLQQLVSFNVEDARTVKIVPFDVTALAAIEKALRDSDLGVNPSNDGAAIRVVMPEMTAERRKEYTKLVNHKAEEARISVRNIRRHAKTTIDKYVKDGEIGEDDGARAEKELDALTKKHVDTIDELYKHKESELLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3N2</accession>
    <name>A0A2Z5R3N2_9MICC</name>
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        <submittedName>
            <fullName evidence="3">Putative esterase/lipase</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1380</name>
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    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="54"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="205" mass="22430" checksum="F97C630A124965CC" modified="2018-10-10" version="1">MNIFENSLEPVRRIRRKVHERQQTGGVPAQQPDFNHEPLSSPADPKKYAGDLGILIVHGFTGSPHSLHPLAAYLAEKGYPVELPRLPGHGTHWRDMAVTHYTDWIDSVEQAYERLTGAGYRVIVIGMSMGGCLAAHLAARRPVAGTVLINPFFVDVNPLMRIAHRVAPVLPVMRSIGSDIAVPGVDEGAYARTPTASIRQLHLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3X7</accession>
    <name>A0A2Z5R3X7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88099">
        <property type="protein sequence ID" value="BAV88099"/>
        <property type="gene ID" value="RA11412_1800"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1800"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021403">
        <property type="entry name" value="DUF3043"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11241">
        <property type="entry name" value="DUF3043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="193" mass="21884" checksum="036F2426675797CE" modified="2018-10-10" version="1">MFGRKSKVEKSPIEAVEPVEEAEPQVSKNSGYTAPKGRPTPSRKEREAARRKPIVGGDRQAAKEAQREQRAQDRKLHAHALRTGDEKYEKYLPAQHQGRQRRFVRDYVDARRNVGDYMLYVLGGCLLIGLIFAGTQLSFAPQVYTATVYIMYGYLFLFALDLWFLWRKLKGILVGKFGEAQRGSVSYILGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R423</accession>
    <name>A0A2Z5R423_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thrS</name>
        <name evidence="14" type="ORF">I6I94_00380</name>
        <name evidence="13" type="ORF">RA11412_1930</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88229">
        <property type="protein sequence ID" value="BAV88229"/>
        <property type="gene ID" value="RA11412_1930"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1930"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="296"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV88229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT89135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="678" mass="75790" checksum="43E8FE6EEAAAA5F7" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4U5</accession>
    <name>A0A2Z5R4U5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplC</name>
        <name evidence="9" type="ORF">RA11412_2570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88869">
        <property type="protein sequence ID" value="BAV88869"/>
        <property type="gene ID" value="RA11412_2570"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2570"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="210" mass="22268" checksum="59F4991D88F566A0" modified="2018-10-10" version="1">MKGLLGTKLGMTQVWDEDGKFVPVTVVKADSNVVTQIRNQETDGYTAVQIGFGAIDSRKVTKPLAGHFEKAGVTPRRHLVEVRTADAAEYTPGQELTVEMFEVGQKVDVVGKTKGKGFAGVMKRHGFKGVGASHGQHKNHRKPGSIGGASYPARVFKGMRMAGRMGAARHTTLNLTIQGVDAENNVLLIKGAIPGPKGGVVLVRTAVKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QV90</accession>
    <name>A0A2Z5QV90_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">23S rRNA methyltransferase rlmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86303">
        <property type="protein sequence ID" value="BAV86303"/>
        <property type="gene ID" value="RA11412_0004"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0004"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="78"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="260" mass="28085" checksum="6B03391D244CA1E2" modified="2018-10-10" version="1">MAKAGSRPGATAKKKGATKGTGGHGRRALEGKGPTPKAEDRVYHKAYKMKRAAERRAATGTNRKFQTRLGGKRVSDELVTGRNAVLEALRTNIPAKHLYVMSRIEVDDRVRDIMTMANKKNLPMLEIPRSELDRLTDGAVHQGIAMQIPPYQYPDATDLVLDVMQRWHAGKLKSPPLFVALDGITDPRNLGAIIRSVSAFSGDGVIIPERRSAAVTAGAWKTSAGAAARIPVAKATNLTRVLQQAKEQGMFVIGLDGGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QV98</accession>
    <name>A0A2Z5QV98_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Osmosensitive K+ channel histidine kinase KdpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86311">
        <property type="protein sequence ID" value="BAV86311"/>
        <property type="gene ID" value="RA11412_0012"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0012"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="143" mass="15690" checksum="FB54E8D1A0F2BD34" modified="2018-10-10" version="1">MANVSHELKTPVGAIGLLAEAIEEASDDPQAIEYFTGRLRRESQRLSALVRDIIELSRLQSADVIARGTLVSTDALVNEALDRNRLAAEAKSIVLQAQVHYSGELYADPELLGTALHNLVENAVRYSPEKTRVDLLIEREGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVQ3</accession>
    <name>A0A2Z5QVQ3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86460">
        <property type="protein sequence ID" value="BAV86460"/>
        <property type="gene ID" value="RA11412_0161"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0161"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="42" mass="4657" checksum="61A674961B83BDBF" modified="2018-10-10" version="1">MRETKNAAKFSVKIAERSIPSGAVSWVIKRPAAGDIFRRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVS3</accession>
    <name>A0A2Z5QVS3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate dehydrogenase E1 component alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86493">
        <property type="protein sequence ID" value="BAV86493"/>
        <property type="gene ID" value="RA11412_0194"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0194"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="3">
        <location>
            <begin position="7"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="208" mass="23677" checksum="7ABA44B5E722DEB4" modified="2018-10-10" version="1">MKPAVGVYFGDGSSTEGEAHEAMVFAASYDAPVLFFVQNNRWAISVPFDVQSRVPISTRAQGYGFEGLRVDGNDVLGTLAVTRYALDKIRRGEGPVLIEAETYRLGPHTTADDPTKYRDDEELQQRLNADPLIRLEKYLRENGHTDDSFFEKLAEEAQELANGVREAAIASEPYEFDRFFDRAYAEEHLQVEEEREFYRNYVAGFEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVW3</accession>
    <name>A0A2Z5QVW3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_07645</name>
        <name evidence="1" type="ORF">RA11412_0135</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86434">
        <property type="protein sequence ID" value="BAV86434"/>
        <property type="gene ID" value="RA11412_0135"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0135"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008667">
        <property type="term" value="F:2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003560">
        <property type="entry name" value="DHB_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01397">
        <property type="entry name" value="DHBDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="255" mass="26756" checksum="294FA8FF3F744FE6" modified="2018-10-10" version="1">MSWVIVTGANGGIGAATVHELIKNNYSVYAADLAETPHESFAAYSDTTFRYSPVNVGDEESVRALAHAAAEMGEPIKGAVLAAGIAHSQPLLDTSFEDWKRLHAVNADGVFLCLREIARVMIEQVQATPENTRSLVTVASNAARVPRAEFGAYGASKASAVRVSSSFGLQLARHGIRVNTVCPGTTRTPMVTDAWGGEDLSALPVAGSPETFRLGIPLGRIADPADIAAVNAFLISDASRHISMQNIVADGGATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVY2</accession>
    <name>A0A2Z5QVY2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86567">
        <property type="protein sequence ID" value="BAV86567"/>
        <property type="gene ID" value="RA11412_0268"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0268"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="48" mass="5224" checksum="F0112755F89A786D" modified="2018-10-10" version="1">MFTVVYSIFELVASAAVRARSLTQAWMERTSSRLAAFCSRVAWPAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW31</accession>
    <name>A0A2Z5QW31_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="8">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0318</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86617">
        <property type="protein sequence ID" value="BAV86617"/>
        <property type="gene ID" value="RA11412_0318"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0318"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="317" mass="35250" checksum="129196802E05D7DA" modified="2018-10-10" version="1">MHKEFGVPSGTLLSGEHEGMKMTTVHPALSYELYPPRSHASCDSLLKTITELEQTNPDYVSVTYSGDAQRRQKTLALLDHLVHETSLNPLAHLICVGHSVADLERSVRLILGLGVRGFLALRGDIPPENTRPLELPFARYLVELIRRVEREDFAHLAAGKVSIGVAAYPHKHPESSSLLQDIEILLSKQRAGADFAITQVFFETERYSGLVDAARLAGVEIPIIPGIMPVTSLTRLTKLCELAGLEVPRELAHRLETASEPREMHRIGVEHALDQCRKVLDAGAPGLHFFTFNEHEAVLDVLEELDVPRYSNRFKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW40</accession>
    <name>A0A2Z5QW40_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86606">
        <property type="protein sequence ID" value="BAV86606"/>
        <property type="gene ID" value="RA11412_0307"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0307"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="147" mass="16269" checksum="30F3F17E455CF064" modified="2018-10-10" version="1">MGLCGRTTQFEHRQSAVTTPHQLTVRAVYPPDYRSDITFMGLFPTAIPKGEPVIGVAVVGSAEYTFTNIPPGTYYLLACEVRFGVHPLKALSQNYRAKADSSITFDAATTPEPVHLMMRLPLPEDPPITMNFPVLLARYLLSSRKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWD5</accession>
    <name>A0A2Z5QWD5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na+/H+ antiporter NhaA type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0419</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86718">
        <property type="protein sequence ID" value="BAV86718"/>
        <property type="gene ID" value="RA11412_0419"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0419"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023171">
        <property type="entry name" value="Na/H_antiporter_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004670">
        <property type="entry name" value="NhaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30341">
        <property type="entry name" value="PTHR30341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06965">
        <property type="entry name" value="Na_H_antiport_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="306" mass="32544" checksum="04E2A26FBF7E212A" modified="2018-10-10" version="1">MHGWAIPTATDIAFAVAVLAGVGTHLPSAMRIFLLTLAVVDDLIAICIIAIFYTNNFHGEYLLAAVIPIGLFALIAYKGEKMFHLKPAAAWIILLPLGFITWALFLESGIHATISGVVLGFCVPVKFNKRTEAAGADSGLAEVFEHRFRPISTSICVPVFAFFSAGVALGGFDGLGRALSDPVAIGIIFALVVGKTLGITGTTWLVTRFKHANLDPDVKWIDIIGLAVTGGIGFTVSLLVAELSFPHGSPHTEDAKIAILFGSITAAILGAIILSRRNKHYKAVAEKEELDENHDGIPDVFEGKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWF9</accession>
    <name>A0A2Z5QWF9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_06235</name>
        <name evidence="6" type="ORF">RA11412_0458</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86757">
        <property type="protein sequence ID" value="BAV86757"/>
        <property type="gene ID" value="RA11412_0458"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0458"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="219" mass="23149" checksum="204B90F392C67F7C" modified="2018-10-10" version="1">MAGETVVTVIGNLTSDPELRFTPAGVAVANFTIASTPRTYNRNSGQWEDGEALFLRASIWREYAENVAETLKKGTRVIAQGRLRSRSYETREGERRTSMELDLDEIGPALRYATAQVTRSHRNSGGGAQQGNNYGGNTFGGQQQAGGYNAAPQQGYNSNSGGGNGYSNNSGYGASAPAAGAAPAQSQQQQQQAPSADPWSSQAGGNYDWGTAGDDEPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWG9</accession>
    <name>A0A2Z5QWG9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsF</name>
        <name evidence="7" type="ORF">I6I94_06230</name>
        <name evidence="8" type="ORF">NCTC10207_02412</name>
        <name evidence="6" type="ORF">RA11412_0459</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI25090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887423.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86758">
        <property type="protein sequence ID" value="BAV86758"/>
        <property type="gene ID" value="RA11412_0459"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0459"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI25090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="101" mass="11520" checksum="C7E3B461CDAC39F8" modified="2018-10-10" version="1">MRAYELMVIFSPEVEDRAVEPSLSKFLEIVTNAGGTIDNMDIWGRRRLAYEIQKKSEGIYAVVNFTATPETSAELDRVLNLNESVMRTKIIRPEEQKISAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWJ0</accession>
    <name>A0A2Z5QWJ0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_0496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86795">
        <property type="protein sequence ID" value="BAV86795"/>
        <property type="gene ID" value="RA11412_0496"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0496"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="63"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV86795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="101" mass="11793" checksum="AA30A7082CABB078" modified="2018-10-10" version="1">MICPDCYRDVTGHSRPQRARTSNNPNITYTLIGINVVVYLLQWIIPNYWVYNEFAYKADWVAYSHEYYRAITSGFLHSQNDPSHLLLNMVSLYLFGAAIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWJ8</accession>
    <name>A0A2Z5QWJ8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MutT/nudix family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">NUDIX hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">RNA pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_06215</name>
        <name evidence="7" type="ORF">NCTC10207_02415</name>
        <name evidence="5" type="ORF">RA11412_0462</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI25096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887432.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86761">
        <property type="protein sequence ID" value="BAV86761"/>
        <property type="gene ID" value="RA11412_0462"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0462"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV86761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VEI25096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="166" mass="18762" checksum="43FF2F7E5DD574AF" modified="2018-10-10" version="1">MSFPVPRAPKMRTLLTASYTPVHREVSAGGIIIDFARQSLPAAIIARINRAGRVEWCLPKGHIEEAETLEEAAQREIEEETGIRGDILHSLGNIEYWFTSSGQRIHKTVHHYLLKATGGEITIDNDPDHEAVDVAWVPFTDLNRRLSFANERHIADLAREFIQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWM5</accession>
    <name>A0A2Z5QWM5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase domain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05935</name>
        <name evidence="2" type="ORF">RA11412_0519</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86818">
        <property type="protein sequence ID" value="BAV86818"/>
        <property type="gene ID" value="RA11412_0519"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0519"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="154" mass="17364" checksum="B1C46695207C7C00" modified="2018-10-10" version="1">MRADYSQLAPESFKAMMALEGTLTLDTTIKELVKLHISQINGCTFCTDMHAKEAKLHGERELRLYHLPVWRESPLFTDKERAALEWAEKLTRLEGSHVSDADYAQVSAQFDEKELAELTFVITVINAWNRLGVAYATDPGSMDKMMGLDKAGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWP4</accession>
    <name>A0A2Z5QWP4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_06255</name>
        <name evidence="1" type="ORF">RA11412_0454</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86753">
        <property type="protein sequence ID" value="BAV86753"/>
        <property type="gene ID" value="RA11412_0454"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0454"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="550" mass="61646" checksum="2475EA23119BF828" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWR8</accession>
    <name>A0A2Z5QWR8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05770</name>
        <name evidence="2" type="ORF">RA11412_0578</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86877">
        <property type="protein sequence ID" value="BAV86877"/>
        <property type="gene ID" value="RA11412_0578"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0578"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="129" mass="13826" checksum="456A7BE2558AFAB5" modified="2018-10-10" version="1">MTNVMKKDNGSSRAALGLMAVAIVALAATGWIAAVVTSDDPGISRLEPWWRGFSAISVLLALLWAAHIFLSRRVPLIGSIGLAVASMIIMVYGVAFFRPLGWGELLWVVVALFLLIALVKLLEPDAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX10</accession>
    <name>A0A2Z5QX10_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exodeoxyribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86977">
        <property type="protein sequence ID" value="BAV86977"/>
        <property type="gene ID" value="RA11412_0678"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0678"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="55"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="312" mass="34593" checksum="E3E35A33EC78AC54" modified="2018-10-10" version="1">MEETAVFSNMLCKECSPLQLRKGGARLVRSESFTGETFTVAWQGAHGKLVYMKIATWNVNSIRARADRIEDWLDKTEVDVLALQETKTKDETFPFELFEFLGYEVAHYGLNQWNGVAIASRVGLDSVERAFPNQPAFGKPGDPAEIEARAIGATCNGVRIWSLYVPNGRGLTDPHMPYKMEWMRQLRTNVNGWLHADPAAQFALVGDWNVAPEDTDVWDIDFFRENDLTHVSAPNARHSMPCSMMKGSSIRCAPTPRASTPTGTTKPGGSRRMRGCASTFSCAPRRSPPVWKTPGSIGKSAKGTVRATIPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX19</accession>
    <name>A0A2Z5QX19_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86987">
        <property type="protein sequence ID" value="BAV86987"/>
        <property type="gene ID" value="RA11412_0688"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0688"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="127" mass="13820" checksum="FF45B448AE050D49" modified="2018-10-10" version="1">MLLYDPDCGFCAAAADMLARLGPQVRIMAGTPAALEYYGVCADRFAHAIPLVNARHHAIFGSDAIALALRTHRAPLLRLTGWMLLRAPVRPLAHRAYRFIAENRPLISRAAAKAGARWGESCSISPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX23</accession>
    <name>A0A2Z5QX23_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05345</name>
        <name evidence="2" type="ORF">RA11412_0679</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86978">
        <property type="protein sequence ID" value="BAV86978"/>
        <property type="gene ID" value="RA11412_0679"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0679"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="38"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT90012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="291" mass="32187" checksum="5B2FAA644BF0F95A" modified="2018-10-10" version="1">MSRNLTSEPVATGSAETRIGLLRWREYGGPREAAGERTLLFVHGLLTNSDVWGEVVQNLSQDFRCITLDIPLGSHTIPAREDAALNVAELAQAVNEAAEQLCPHGFTLIGSDTGGVVSQLAAVQEPTGLKRLVLLSCDTEKNFLPLPLRYLQYVAYIPGTMQALRAALHLGWVRRLPIAFGWLVKRELDAAEWNSIIAPLKNAGVRRDLAKVLKGISVKYTVQSARDLERFEHPTLFLWADTTKLFPIENARRLATRMPDAHVVPVPESYAFSQLDQPEFVANALREELAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXA3</accession>
    <name>A0A2Z5QXA3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86854">
        <property type="protein sequence ID" value="BAV86854"/>
        <property type="gene ID" value="RA11412_0555"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0555"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="103" mass="10759" checksum="AC304824F3A4CFD6" modified="2018-10-10" version="1">MLGAFALGVLTAWWSRRAARYGDEAVRPQRLLFGTGLLGGYTTYAALIAALNIFDEHNGTGDALIARLVWAAMLVCVAGLAASGAGLWVGSKIPSAPGGRQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXB8</accession>
    <name>A0A2Z5QXB8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Manganese ABC transporter SitB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Metal ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_05320</name>
        <name evidence="6" type="ORF">RA11412_0684</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86983">
        <property type="protein sequence ID" value="BAV86983"/>
        <property type="gene ID" value="RA11412_0684"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0684"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT90008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="266" mass="28409" checksum="D988D028F0AD5056" modified="2018-10-10" version="1">METLLNVENLGVNYGSVQALHNATFRLGAGSICGLIGMNGSGKSTLFKAIMGVTPAHTGSVEIAGGDPAAARKSGVVSYVPQSEEIDWSFPVSVRDVVAMGRYRTLGPTRRLHSKDKQALAHALERLELTDLAARQIGALSGGQRKRAFVARAIAQGARLLLLDEPFAGVDKRSEAMLIDVLKQLRDSGASVLVSTHDLASLHSFADEAVLLRKTVLMHSTPEAVLAPENLVQAFGMHINTGHSPSTPEKNTANNTDEQVKRVNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXD4</accession>
    <name>A0A2Z5QXD4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86996">
        <property type="protein sequence ID" value="BAV86996"/>
        <property type="gene ID" value="RA11412_0697"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0697"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022454">
        <property type="entry name" value="CHP03883_F420-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03883">
        <property type="entry name" value="DUF2342_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="380" mass="41961" checksum="7BC3B65A97F7426F" modified="2018-10-10" version="1">MHMSENSIQDLLNPEAVTKIVGTLAPAGPRIAPDKMRQAVESIRAAAEVSVDHVHRITGLEAAHNLRDSQVLVTDRSTWAKANAQAFSVMLEPVLRAPLEKIRQKNPAALSITRYGIATEVGSILAYLSTRVLGQYEPYAALAGYGAAGGRLMLVAPNILAVEKELNVEPEDFRLWVCLHEQTHRVQFAAAPWLRDYFLNKIAQLGDSVSTGLSIKDALVASKGARTDEADNEPQIGEQLAALAKTPARAKQIASEITAVMSLLEGHANVIMDAVDAEIVPTVKTIRRRFNRRSETQKLVTRLISRLLGLHRKAAQYRDGQKFVQHIVDAVGMERFNVVWERPENLPTEREIHNPDAWMKRVLDEGSEVTSAVKHGETTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXE3</accession>
    <name>A0A2Z5QXE3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine/uracil/thiamine/ascorbate permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87102">
        <property type="protein sequence ID" value="BAV87102"/>
        <property type="gene ID" value="RA11412_0803"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0803"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="89" mass="10052" checksum="115C8EF19A298A7A" modified="2018-10-10" version="1">MVFVGFLMIRQAVHIDWQDWGLGIPAFMTIIFMPFAYSIADGIGAGFISYVFIRLVQGRGREVHWLMYVVSAVFLVFFSTGLINGFTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXG1</accession>
    <name>A0A2Z5QXG1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heme ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_0838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87137">
        <property type="protein sequence ID" value="BAV87137"/>
        <property type="gene ID" value="RA11412_0838"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0838"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="82" mass="8754" checksum="CB7EFDF7AB5FEF93" modified="2018-10-10" version="1">MILTGIAVTAVANAAIAFCVYVADSTSRDEIVFWQMGSLNRASWTSLSNMWFVVVAALLACFMISGKLDLLALGERAAQHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXG6</accession>
    <name>A0A2Z5QXG6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heme ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0839</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87138">
        <property type="protein sequence ID" value="BAV87138"/>
        <property type="gene ID" value="RA11412_0839"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0839"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_BtuC-like"/>
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        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
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        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="47"/>
            <end position="68"/>
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            <end position="128"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="158"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="160" mass="17754" checksum="FCA295363942E475" modified="2018-10-10" version="1">MEHVAEDLAVTSETARQRPADEVDLTKVQKPVGAGAPKYTNPRRTRAVVTLSVLVVTLVAVTIVSAGLGQYNIPTDQVLASFARKWGFIPPQQEWAIADSTLWNVRFPRVLLALFVGAALGCSGLLCRRCLATRWLSREWLVFLQVQLWVPAWLLCWAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="BAV87205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <location>
            <begin position="443"/>
            <end position="656"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="697" mass="75197" checksum="A60695A42425C12D" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXM3</accession>
    <name>A0A2Z5QXM3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0777</name>
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    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87076">
        <property type="protein sequence ID" value="BAV87076"/>
        <property type="gene ID" value="RA11412_0777"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0777"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="38" mass="4296" checksum="A03A918C90ADDE14" modified="2018-10-10" version="1">MLRRSTGPSFERYTLRCRETEDTSSLPAVESVFDAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXX5</accession>
    <name>A0A2Z5QXX5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved repeat domain</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0785</name>
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    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87084">
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="275" mass="30225" checksum="9D65C11D4D0DFEC5" modified="2018-10-10" version="1">MPGELATEADLDRITEVFASLPLRNPDGTRGVSIHLDAGPARSAKYNLGGGNEIPHQKLNGMGDWAALKNRHFASARDAGFHYMIWGDYYGNTSSSGLGFTGARGFIVTVGHTYWRGASSDIRVGTFIHELGHNLGLRHGGADEENYKPNYLSIMNYEYQLSGVPRAGGKNYFGYSTHEHMPLDEKNLDERRGLGANAYGYLCKGKPAHRNVDFNKNGVIDAQPVAADVNGNRRMSTLRAKSDMKTLRFAASATSQGVTSTRGRTPMRLRWTITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXZ3</accession>
    <name>A0A2Z5QXZ3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor AcnR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Regulatory protein TetR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acnR_2</name>
        <name evidence="4" type="ORF">I6I94_03990</name>
        <name evidence="5" type="ORF">NCTC10207_00471</name>
        <name evidence="3" type="ORF">RA11412_1013</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888056.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87312">
        <property type="protein sequence ID" value="BAV87312"/>
        <property type="gene ID" value="RA11412_1013"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1013"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="52"/>
        </location>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VEI22396.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="189" mass="21357" checksum="36DA907D430DE3A3" modified="2018-10-10" version="1">MPKVSEEYKKNRRSQIIDVARECFIKHGYQKTSMNEIIAATGLSAGAIYNHFGSKNDIMLEAARLDLAPFTRVRADKPWDYVLGCLRLLDATKTRRFLLATWGEAVSSPDISAVVTEQLTDLRDMALDRYREWGSRELDFTEEELDGWLDVIGAAVLSVLTGYVVQTQLLGKEKRDAYLEYASAILTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY17</accession>
    <name>A0A2Z5QY17_9MICC</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">JCM 11412</strain>
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    </dbReference>
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    </dbReference>
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            <begin position="43"/>
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            <begin position="720"/>
            <end position="742"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="922" mass="97267" checksum="438828A9C6458B15" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY31</accession>
    <name>A0A2Z5QY31_9MICC</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="evidence" value="ECO:0007669"/>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYC0</accession>
    <name>A0A2Z5QYC0_9MICC</name>
    <protein>
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    <organism evidence="2 4">
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT89674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="RA11412_1166"/>
    </dbReference>
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    </dbReference>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QQT89674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="262" mass="25491" checksum="8974F5A648AB285A" modified="2018-10-10" version="1">MSSTSGNESAASKLANTAGEAAANIPRTGVSGKRWLAILGAGALIVSGSVFAYNSLHKEEEAFTADGGEEFAQVCQDAKTGRRVEDSECEKAGEAANSSDSSSSSNSNNSSHNNSGSNSNSGTHNNQSHVTNAFLWYYIGSQAGRNASIPAVGSSLTGGSTSRPSSGTVYSGVSSKGGGFESSYRSAKKTSTVAGGKVTSTTSGGKSSSAKSGSNPGSRVGSNKSGSNSGGSKSGSNSGSKSGGSKGGFGGGSKSGGGTSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYC5</accession>
    <name>A0A2Z5QYC5_9MICC</name>
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        <submittedName>
            <fullName evidence="1">Mycothiol S-conjugate amidase Mca</fullName>
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    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87353">
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        <property type="gene ID" value="RA11412_1054"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="102" mass="11347" checksum="3C1639910AF97890" modified="2018-10-10" version="1">MARDGQSVFSGWIENLVDQVSTEGIRHESTTRIPSSAYFDRRDQAMLAHASQIDPNGAFFAIPTEDVKKVWPWEDYTLIASRVPVDLPECCLADGLDYKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYE3</accession>
    <name>A0A2Z5QYE3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_1074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87373">
        <property type="protein sequence ID" value="BAV87373"/>
        <property type="gene ID" value="RA11412_1074"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1074"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="200" mass="22237" checksum="7CC27A73797F54D1" modified="2018-10-10" version="1">MSSLPSRIKAIWNTYGIEIAKFCTVGGAAFVVNSVVVWTLMVTIMHDSHTKAKVIASVVATIFSWLMNRLWTFRENRSENWKREAIEFAFVNILGILVEAGCVAFSTYILGLRTAQASFISGTIIGTILGTILRYFLYRFWVYGKHRKQVAEGGATEHEELGHMLEEATEIMTHDSEAEAVIAQESAAEAEVSNGNKINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYK9</accession>
    <name>A0A2Z5QYK9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative iron-sulfur cluster assembly scaffold protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">SUF system NifU family Fe-S cluster assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03525</name>
        <name evidence="2" type="ORF">RA11412_1137</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87436">
        <property type="protein sequence ID" value="BAV87436"/>
        <property type="gene ID" value="RA11412_1137"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1137"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="37"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="157" mass="17197" checksum="2B40553A1D70C6D2" modified="2018-10-10" version="1">MSLESLYQEIILEHSKQRSGEHLVEVPNGRCSADNHQYNPTCGDEINLRLVLAQEPQDGEQVIESVSWEGDGCSISMAAASVLSEMAPGMTVGELQHHVDAFRQMLRSRGQITLDEEEYGDMAAFSGVSKFMARVKCAMLSWVAAEEAAREAAGKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYL3</accession>
    <name>A0A2Z5QYL3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="1">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosyl pyrophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_1101</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.6.1" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87400">
        <property type="protein sequence ID" value="BAV87400"/>
        <property type="gene ID" value="RA11412_1101"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1101"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="247" mass="26677" checksum="3DE62508ACA1EEEA" modified="2018-10-10" version="1">MIDALKRASARSVTVVSPFYPYARQDKKHRGREPISARLIADLYKTAGADRLMCVDLHTSQIQGFFDGPLDHLFAIPVLAEYIKSRVENPENVTVVSPDTGRVRVAEHWATLLGGAPLAFVHKTRDINVPNQAVSKTVVGEIEGRSCVLIDDMIDTGGTIAGAVNVLKEKGAKEVIIAATHPVFSGPAVERLSGCGASEVVVTNTLPVPDDKRFENLTVLSIAPLVARAIREVFDEGSVTNIFNDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYM9</accession>
    <name>A0A2Z5QYM9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrolipoamide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87456">
        <property type="protein sequence ID" value="BAV87456"/>
        <property type="gene ID" value="RA11412_1157"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1157"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="278" mass="29942" checksum="DEBE792C1F89C92D" modified="2018-10-10" version="1">MKRLNARVLELAQQQSADIKRALSAAGVKIVQGTGKLLDRHTVEVTDEAGLTYNLHADFILLSVGTHPREMATGRPDGERILTWTQLYNLQEVPKELIVIGSGVTGAEFASAYEGLGSQVTLISSRDRVLPGEDEDAARVLEDVFERRGVQVMPRSRASAVERSEDGVVVTLSDGRKVAGTHCLVAIGSIPNTEGLGLDAAGVEVSDSGHVVVDGVSRTCVNNIYAAGTAQACTRSPRLLRCRGASLWRTFWGMRSSRCAPTGWRAIFSPPPKLPPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYR5</accession>
    <name>A0A2Z5QYR5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-acetylhomoserine sulfhydrylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87496">
        <property type="protein sequence ID" value="BAV87496"/>
        <property type="gene ID" value="RA11412_1197"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1197"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="301" mass="32868" checksum="62634CC90CC4235C" modified="2018-10-10" version="1">MQQWREAVRPNTKLFFGETVPNPRNDVLDIELIAQIAHEAGVPLIVDNTVPTPYLVRPIEFGADVVVHSATKYLGGHGTSIGGVIVDSGNFDYGADPKKFPKFNEPAPSYHGLVYARDLGKDSAFGANLSYILKARVSLLRDTGAAISPTNAFNIGIGLETLSLRIERHIENATKVANWLEEHPLVDRVIWAGLPSSPWYERAQKYLPKGPGAVVGFTLKDADLEQTRTFVDALQLHSNVANIGDVRSLVIHPASTTHSQLSEEELEAIGVSKNFVRLAVGIENIDDIIADLELGFATLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYU2</accession>
    <name>A0A2Z5QYU2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87526">
        <property type="protein sequence ID" value="BAV87526"/>
        <property type="gene ID" value="RA11412_1227"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1227"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="4532" checksum="240348E713893147" modified="2018-10-10" version="1">MVFHPAGFNPLLTLFYAIAGDVSGGMFFPSVSRGKNAEEVEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYY0</accession>
    <name>A0A2Z5QYY0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87491">
        <property type="protein sequence ID" value="BAV87491"/>
        <property type="gene ID" value="RA11412_1192"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1192"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="40"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="151" mass="17043" checksum="161A7AF6D81DA405" modified="2018-10-10" version="1">MSPASSGFLVEKVIFSPSRPKICCLCVPEITPPLTGDYIVTYSRVMDDDAVFKALADPTRRKLLDKLYTTGGLTQGQLEEGLGMTRFGVAKHLRILEEANLVITQRSGRQKLHYLNAVPIRRIHDRWIDKYTAHQSSALLDLQKNLEEEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ64</accession>
    <name>A0A2Z5QZ64_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_02645</name>
        <name evidence="2" type="ORF">RA11412_1354</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87653">
        <property type="protein sequence ID" value="BAV87653"/>
        <property type="gene ID" value="RA11412_1354"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1354"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="311" mass="35104" checksum="E2E7B7F555BE20B8" modified="2018-10-10" version="1">MTTNMNTQQPDDELQHWRSSVQDYISRKDDINLYIAAQNLNRLAPADPLGLFGLAKAQRHRGELEPAYFNITQARQRSAEPVEGMLLLEAQLSQQLNQHAVAADRYAELIALNPLEPGYVTARAEALRLSGHTEEADKELRKGRDFFQYDQTLHDSGVEAAVATAEKDAININQKPAYLTAEAAKNALEILRKPEPLESVRTASAHLRERYENLQTAAEYALKRHFVWREWWQMIIIGLFLLFLIPFEYGVLHGAVAGILETPTFTEIFGTVFAVLVLLGIPLLLGFIFFFPKGYKISRSKARKAGVLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ70</accession>
    <name>A0A2Z5QZ70_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">1-pyrroline-5-carboxylate dehydrogenase 1</fullName>
            <ecNumber evidence="9">1.5.1.12</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Proline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rocA1</name>
        <name evidence="8" type="ORF">I6I94_02595</name>
        <name evidence="9" type="ORF">NCTC10207_00769</name>
        <name evidence="7" type="ORF">RA11412_1367</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.5.1.12" evidence="9"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037236401.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87666">
        <property type="protein sequence ID" value="BAV87666"/>
        <property type="gene ID" value="RA11412_1367"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1367"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
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    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
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    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025703">
        <property type="entry name" value="Bifunct_PutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="6">
        <location>
            <begin position="133"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="517"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="454"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="715"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000197-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VEI22684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="1163" mass="127011" checksum="F13CDC20D4DB7467" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ73</accession>
    <name>A0A2Z5QZ73_9MICC</name>
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        <recommendedName>
            <fullName evidence="2">DUF6493 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_02305</name>
        <name evidence="3" type="ORF">RA11412_1438</name>
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    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="185"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89481.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="879" mass="96823" checksum="1069051E13BE2F0F" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ91</accession>
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        </submittedName>
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    <organism evidence="2 3">
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87600">
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        <property type="gene ID" value="RA11412_1301"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1301"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="72" mass="7771" checksum="239E5418D8F856CC" modified="2018-10-10" version="1">MGLILALLGVSMTLLTGNGLWDAAGTLAIGVLLVVIAVFLASEMKSLILGRQQLPRIWRRSARLLRTVILTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZC0</accession>
    <name>A0A2Z5QZC0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_02010</name>
        <name evidence="1" type="ORF">RA11412_1513</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87812">
        <property type="protein sequence ID" value="BAV87812"/>
        <property type="gene ID" value="RA11412_1513"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1513"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="368" mass="38726" checksum="4ED433AFFF0B975A" modified="2018-10-10" version="1">MAEFTRTPDASSEKYPLAVRTALLCAAMGDALGYPLELLSAKEIAARGPLTGENELIFSDDTQLSCYTLDALTEVLEWNNQGTPADELACLWLAYLRWYRGMGFTPAAHAPFSLDREIDASAPLTAREGPGQATLRALESGEMQTVAQNINPDALGTGALVRSCAFGFLPVAPERTVVLLAARAAALTHGHPEALASAAAYALLTRDVLAGACGSEQGKKNSIADSVRRVIDWCGSIPAEEAFPADAAHTREALVKALALQETEPTPEAVAEHFGTDWLCYTVLGIAVWNTLYCSARISASGEGLQAGLMRAVSADSDSDSIGAITGALLGAHVGTLGDTQPLLETLRGAADVRAVADRYIAQLGQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZI0</accession>
    <name>A0A2Z5QZI0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_1402</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="372" mass="41606" checksum="0524CC6EE0FA1958" modified="2018-10-10" version="1">MVLLYLGLIYCSVTIMVRTSDRFVRLAAGGITVWITAQALINMGMVTGVLPVIGVPLPFISYGGSSLLASMFAAGLLFAFSRQAPVYPLRRDPNRNLSPREIRRENEDWQRRLVLGQAVAEENRRMVQAGGALGLDVWHWRSQLRDAIHGLLVWLGLSSEQRARAHQRRVQQRELAVREAQKQQAAERERELLERQRLQQAQNSRLSGQNVQRPDGPVRQLRGNNGPQPRPAQLSSLRQLTGVGENGSGLSQNAPLQLFREAVRLALALLLSSGRVLHGPRPKAQRSKGRLVVRMRSVLLHAARRFRGVTVLRAKLSPRRRVRAVRSALVRSRRACVRCMGALRRMRRQSPVMVPGKPHGGQAQLRRASGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZJ1</accession>
    <name>A0A2Z5QZJ1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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        </location>
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            <end position="186"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
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    <name>A0A2Z5QZP8_9MICC</name>
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87836">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF1963"/>
    </dbReference>
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        <property type="entry name" value="YwqG-like_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="174" mass="20062" checksum="9AD174EE891CAF40" modified="2018-10-10" version="1">MGIDKEEDHRVIYYPQLGEANPDAVATCEDRERDFWWPIKHECALEFTTLGREIFAPNDSINHPLIEKWNQAYPEQAITSLFDLDVYDVEEIEEITGSGDYSKLGGLPHFMQGDPRREEPENSDIRRRTVNLLTMDSYGNTVLWGDVGTANWLIAPDRLAARDFSQVFYEWSCG</sequence>
</entry>
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    <accession>A0A2Z5QZS4</accession>
    <name>A0A2Z5QZS4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ComA operon protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87958">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="BAV87958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="90" mass="8995" checksum="C57750EEE6257B3E" modified="2018-10-10" version="1">MTDSSLELSPTVIAELTAHGVPEKLHPLFPHGLGGLIPAMGIRLSELSAERAVATMPVAPNTQPAGLLHGGASVVLAETLGSLASGVHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZU6</accession>
    <name>A0A2Z5QZU6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87886">
        <property type="protein sequence ID" value="BAV87886"/>
        <property type="gene ID" value="RA11412_1587"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1587"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="4574" checksum="37085FDFC8CBE424" modified="2018-10-10" version="1">MRASAFSWGSSPRMRGTLFGVEIVEAVEGLIPTYAGNTPCGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZV9</accession>
    <name>A0A2Z5QZV9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Butyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I6I94_01745</name>
        <name evidence="9" type="ORF">RA11412_1604</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87903">
        <property type="protein sequence ID" value="BAV87903"/>
        <property type="gene ID" value="RA11412_1604"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1604"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="235"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="385" mass="41809" checksum="C1C1F196A5043FA8" modified="2018-10-10" version="1">MRPTIEFTEDHELFREAAREFITHEVAAHYPQWEREHMMPRTVWTAAGEAGLLGLAVPEEYGGAGMPDYRYQLVLTQELAAKGCHGFALAVHLQQDLVLPYLLAYGTKEQKQQWLPAMVTGELVTSCAFTEPGAGSDLRACRTTAVREGDEFILNGQKTFIGSGISADAALVLARTETGSTRGGSGSFSLFMVEKSSGYTAGNQLDKLGLRASDTAELFFDNVRIPAQNLVGELGEGLRYVKEQLPQARLAIAAASAVIARTTVEATVSYVKERQVFGSRVADFQNTRFKLVDALMAAETTELYVSRAIDAFNAGALSAAEAAKVKVFASENACRITDTCLQLFGGYAYINEHPVAQAFLAARLLPIFGGTNEVLRDTIGFDLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZW9</accession>
    <name>A0A2Z5QZW9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88022">
        <property type="protein sequence ID" value="BAV88022"/>
        <property type="gene ID" value="RA11412_1723"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1723"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="204" mass="23539" checksum="BF668911E9341763" modified="2018-10-10" version="1">MTPKVPQPSLTERRARLRELLKRDDATFWQYHEVLTGATEDERKGLARTLSIKKLIDRYSREGTTEQRLVCIYTAAALGGTFKHVGVELLNLIDRGLPGEANWKFSTAESEQYLSQRTEAMMLGLSERDNTWITGFVNERGYGRFGYDLPTLWVQIHQLLHERGLTNTTRSYLWGFVTAVPDMHIGSSENREEVISFFKNNPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZY8</accession>
    <name>A0A2Z5QZY8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="5 12">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpE</name>
        <name evidence="16" type="ORF">I6I94_01615</name>
        <name evidence="15" type="ORF">RA11412_1634</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="5 12"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87933">
        <property type="protein sequence ID" value="BAV87933"/>
        <property type="gene ID" value="RA11412_1634"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1634"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 12 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="14">
        <location>
            <begin position="33"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="13">
        <location>
            <begin position="247"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV87933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QQT89360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="529" mass="57220" checksum="66F0EC54C84EC88C" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R018</accession>
    <name>A0A2Z5R018_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87860">
        <property type="protein sequence ID" value="BAV87860"/>
        <property type="gene ID" value="RA11412_1561"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1561"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010148">
        <property type="entry name" value="CRISPR-assoc_prot_CT1975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09344">
        <property type="entry name" value="Cas_CT1975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="65" mass="6969" checksum="206DAEB0F2C78BC9" modified="2018-10-10" version="1">MIGTIEMASSTLYRYANINVDALKTNLGGSAAATVEATLAFIRAFIDSMPTGKQNTFAARTLLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R021</accession>
    <name>A0A2Z5R021_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron-sulfur cluster assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88057">
        <property type="protein sequence ID" value="BAV88057"/>
        <property type="gene ID" value="RA11412_1758"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1758"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="216" mass="23892" checksum="31B182248724FFFF" modified="2018-10-10" version="1">MKKNARVRYTTIQNWSNNVYNLVTKRAVAHEGATMEWVDGNIGSKVTQKYPAVYMVGEHAKGETLSIAFAGEGQHQDTGSKMVHIAPNTSSTIVSKSVARNGGRSAYRGLVQVREGAKHSKSSVVCDALLVDTVSRSDTYPYVDVREDDVTMGHEATVSRVSEEQMFYLMQRGLAEDEAMAMIVRGFVEPIARELPMEYALELNRLIELQMEGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R098</accession>
    <name>A0A2Z5R098_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">msrA</name>
        <name evidence="8" type="synonym">mrsA</name>
        <name evidence="7" type="ORF">I6I94_01785</name>
        <name evidence="8" type="ORF">NCTC10207_00933</name>
        <name evidence="6" type="ORF">RA11412_1595</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023134692.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87894">
        <property type="protein sequence ID" value="BAV87894"/>
        <property type="gene ID" value="RA11412_1595"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1595"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI22843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="173" mass="19319" checksum="088E7D52EAF21797" modified="2018-10-10" version="1">MRSFVVGGGCFWCIDAVFRQFKGVSASVCGYAGGTVPNPDYRSVCSGATGHHEVVRVDFDENVIGEDAVLDIFFASHDPTSWDRQGADTGSQYRSVLLYADEQQRKVFEAAKVRAQALFDAQVVTEIKPLETFWEAEDYHQDYYALNPYQGYCSVVISPKVAAARRKYAHLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0B0</accession>
    <name>A0A2Z5R0B0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">gmk</name>
        <name evidence="12" type="ORF">I6I94_00620</name>
        <name evidence="11" type="ORF">RA11412_1873</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88172">
        <property type="protein sequence ID" value="BAV88172"/>
        <property type="gene ID" value="RA11412_1873"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1873"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="5"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV88172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT89177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="189" mass="21129" checksum="38E36B2BF69748F9" modified="2018-10-10" version="1">MTAKPTLTVLAGPTAVGKGTVCQYIREHYPQVWFSVSATTREPRPGEEEGVHYYFVSMDEFDRMIDEGQMLEYAVVHGKNKYGTPRTKVQQALDAGRPVILEIDLQGARQIRKSMPQAQLVFLAPPSWEELVSRLTGRGTESEQEQQRRLETAKVELAAESEFDVTVVNDTVERAAHEIAQLIGAEPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0C7</accession>
    <name>A0A2Z5R0C7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">RA11412_1625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87924">
        <property type="protein sequence ID" value="BAV87924"/>
        <property type="gene ID" value="RA11412_1625"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1625"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="54" mass="6315" checksum="3431F6F66414A20B" modified="2018-10-10" version="1">MQWWFFTLPAQTHPAPDIPQRLLPPYSAATGRKKQNKVRGYPTERQRNRAPSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0C9</accession>
    <name>A0A2Z5R0C9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide chain release factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00525</name>
        <name evidence="4" type="ORF">NCTC10207_01198</name>
        <name evidence="2" type="ORF">RA11412_1893</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887176.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88192">
        <property type="protein sequence ID" value="BAV88192"/>
        <property type="gene ID" value="RA11412_1893"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1893"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI23101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="159" mass="17772" checksum="20D144DD0AE3928F" modified="2018-10-10" version="1">MGILRSALLLGAGAAVGYLASRRAAYVKANPSSASLIKYQSGALELNPESQMGKFFDSSLGKPLQPYALRAVEFAARVRQGMQEKEAELHAKVERQKQDARPGSLDLWDRDMSPNEASELRRAVAERELIEVESEIAHLEEARQARLRRDRELGEDFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0K5</accession>
    <name>A0A2Z5R0K5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1715</name>
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    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88014">
        <property type="protein sequence ID" value="BAV88014"/>
        <property type="gene ID" value="RA11412_1715"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1715"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="340" mass="36418" checksum="A03328BE41AC18DD" modified="2018-10-10" version="1">MAYELDYNYLGASTLLERDGHPELALATSGGSTPEGAAAHPYFFSGFMERPDVIAASLLVVARVARTRYYTPPGMVAAILRAADPVVTSTREGLRFESFSACCGVYARLDVDSSALDASHSAVGVTNVDVNPPLRTALASLRAGEPLHMDVGDEGLLTTTLDGEVMEDKVPLPVRWLKGFAETQMLSSLMKPTHSLDAAAARTFIQGLPRQSATKSVMWATQAVRSLRLATRATAGSVCVAGPERLRVLEPLIRFMTRLEAYSEPVTSGNAPVASVWVAHLPGARLSIGLSPEKSRGFSGKALCCRRSPTRQLLKTRICSACFSPLSRVLKCPLCLHAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0M0</accession>
    <name>A0A2Z5R0M0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6493 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88026">
        <property type="protein sequence ID" value="BAV88026"/>
        <property type="gene ID" value="RA11412_1727"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1727"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="125"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="603" mass="68254" checksum="7FE3064219BD3BCA" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0M2</accession>
    <name>A0A2Z5R0M2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Excalibur domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88287">
        <property type="protein sequence ID" value="BAV88287"/>
        <property type="gene ID" value="RA11412_1988"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1988"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008613">
        <property type="entry name" value="Excalibur_Ca-bd_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05901">
        <property type="entry name" value="Excalibur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00894">
        <property type="entry name" value="Excalibur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Excalibur" evidence="2">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="105" mass="11178" checksum="9A6E1D422FD8F335" modified="2018-10-10" version="1">MAEPTPEVPAPEPEQKPVPAEETQPATEAPAPARQTPVQQEPVQQKPVVVETPANTGVYYKNCDEVRAAGAAPIHKGQPGYAAHLDRDGDGVACEPYKGKGNKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0M9</accession>
    <name>A0A2Z5R0M9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="9" type="ORF">RA11412_1745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88044">
        <property type="protein sequence ID" value="BAV88044"/>
        <property type="gene ID" value="RA11412_1745"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1745"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="44"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="3"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="341" mass="38948" checksum="EC6EF06F982038ED" modified="2018-10-10" version="1">MEKPFGHDLESARELNAIVERVFPPDSVFRIDHYLGKETVQNILAMRFSNQMFEPVWNANYVDHVQITMAEDIGIGSRAGYYDGVGAARDVIQNHLLQLLALTAMEEPLSLDSKHLRAEKAKVLEAVRVDDLENSYALGQYAPGYQGGEHVNGFFDEKDIPADSRTETFAALKVSIDNRRWAGTPFYLRAGKRLGRRVTEIAVLFKKSADRLFGKETEVPAGQNAIVIRVQPNEGMTIRFAAKVPGTQMEIRDVNMDFGYGHSFTEESPEAYERLILDVLLGEPPLFPRHEEVELSWKILDPFEEYWEEHKIKPEPYESGSWGPRSAHQMLERDNRAWRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Q9</accession>
    <name>A0A2Z5R0Q9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88262">
        <property type="protein sequence ID" value="BAV88262"/>
        <property type="gene ID" value="RA11412_1963"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1963"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="173" mass="19313" checksum="B422E12841C5AB2F" modified="2018-10-10" version="1">MSPQEANESAGFSEEELNTNMQALPGVRPVKPGFSGAGPEEICTRYAIGALTNEQLADELTRWDYNVHAQWNPYHEFRFFMPGSYDELVMAFYKNLIDPTDLQALAARGLPLPADLIEEWEQERELFGHVTAIYRKMFSTAGAQRQAHVVVGAPGRVKASILRTLLRGGTKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0U6</accession>
    <name>A0A2Z5R0U6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88405">
        <property type="protein sequence ID" value="BAV88405"/>
        <property type="gene ID" value="RA11412_2106"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2106"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="45" mass="5403" checksum="B195199CF89E7D1D" modified="2018-10-10" version="1">MGARIYRQRIQRALTRGLEAALNEQVVHPVENEIMRLETYRNHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0U8</accession>
    <name>A0A2Z5R0U8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88111">
        <property type="protein sequence ID" value="BAV88111"/>
        <property type="gene ID" value="RA11412_1812"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1812"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="55" mass="6077" checksum="D5701902CB51AA65" modified="2018-10-10" version="1">MATGEIAQISFIIVSICALGVLFFTWRAVAALVLKLNTRKRNNPTPPEHKHSTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0X5</accession>
    <name>A0A2Z5R0X5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88322">
        <property type="protein sequence ID" value="BAV88322"/>
        <property type="gene ID" value="RA11412_2023"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2023"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="64" mass="7064" checksum="6F4CBE5F9D064805" modified="2018-10-10" version="1">MLIGWGGYGTFTGWQRVVTGKASLDHPIIAGHTYLWSPLFLMWGLLLCGALFVSRARRQKVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Y3</accession>
    <name>A0A2Z5R0Y3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_11040</name>
        <name evidence="2" type="ORF">RA11412_2098</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88397">
        <property type="protein sequence ID" value="BAV88397"/>
        <property type="gene ID" value="RA11412_2098"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2098"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340099" evidence="1">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="193" mass="21130" checksum="D79E28E21779129D" modified="2018-10-10" version="1">MNLSSVTIAVLGSAGYGALCAAATGSVAHKTECDRPVYLWEPADTGETTHQLPVTYTTDIYEALESADIVVVPWDEQADSCPEEMTGVMAFRRWAYLLPQTAIVLAAAGSAEDTMNVSEHLQQILHTEFPTRRERVAVLTITARHLAGTGVMEPVKTHPRRPRTATLTTDDEHMHQLITALFDGPVLRIHRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R157</accession>
    <name>A0A2Z5R157_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="5 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RA11412_1981</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="5 10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88280">
        <property type="protein sequence ID" value="BAV88280"/>
        <property type="gene ID" value="RA11412_1981"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1981"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013554">
        <property type="entry name" value="RNR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08343">
        <property type="entry name" value="RNR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNR_N" evidence="13">
        <location>
            <begin position="31"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuc_red_lgN" evidence="11">
        <location>
            <begin position="114"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="12">
        <location>
            <begin position="191"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV88280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="305" mass="34737" checksum="7CA7D6458B32C8F6" modified="2018-10-10" version="1">MLEAKLPSALETLGASHAGKTTPEKFQGMSYHELNALLNLYDENGKIQFDADRQAARQYFLQHVNNNTVFFHDLEEKIEYLIENQYYEPELFEKYSFDFVKNLFKRAYAVKFRFPTFLGAFKFYTSYALKTFDGQRYLERFEDRVCMVALLLAEGNETLAEEIVDEIISGRFQPATPTFLNAGKKQRGELVSCFLLRIEDNMESIGRSINSALQLSKRGGGVAFALTNLRESGAPIKKIENQSSGVIPVMKLLEDAFSYANQLGARQGRGPCTCTHTTPTFTRSLTPNAKMLMRRSALKPSHWVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R160</accession>
    <name>A0A2Z5R160_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88412">
        <property type="protein sequence ID" value="BAV88412"/>
        <property type="gene ID" value="RA11412_2113"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2113"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="57" mass="6181" checksum="71A403293983F6E8" modified="2018-10-10" version="1">MVGAANTIYEDFKSNFAVDTDPLFVVYDQGSWHMTYDLLPETRGKVPEAAAGTTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1E3</accession>
    <name>A0A2Z5R1E3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chorismate mutase</fullName>
            <ecNumber evidence="3">5.4.99.5</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Chorismate mutase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_10215</name>
        <name evidence="4" type="ORF">NCTC10207_01557</name>
        <name evidence="2" type="ORF">RA11412_2306</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.5" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006889175.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88605">
        <property type="protein sequence ID" value="BAV88605"/>
        <property type="gene ID" value="RA11412_2306"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2306"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010951">
        <property type="entry name" value="CM_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01795">
        <property type="entry name" value="CM_mono_cladeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI23454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="124" mass="13834" checksum="4D6477E27C75876F" modified="2018-10-10" version="1">MSTAEFDPNATSMGEEVAPEVYEELFAMRRSIDNFDAALVHILAERFRATQRVGVLKAKHNLPAGDAGREEAQIGRLRAMAKESSLDPEFAEKFLNFIISEVIRHHERIAIEHNDKDLPSGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1F7</accession>
    <name>A0A2Z5R1F7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RA11412_2047</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88346">
        <property type="protein sequence ID" value="BAV88346"/>
        <property type="gene ID" value="RA11412_2047"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2047"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPG_CAT" evidence="11">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV88346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="303" mass="32252" checksum="8E5492AEE66F4904" modified="2018-10-10" version="1">MPEGHSIHRIARQFNDVFTGERVRVTSPQGRYAEGAALVDGARIAQAFAHGKHLFVGFDNELTLNVHLGIYGNWSFGGDESFTGASSIGAPRKIGEKEYGSGGHSEYSGPPQPKATTRCRIVSEHGWADLVGPTVCRTLTPDEVAVVRGKLGPDPLNADADPGQFYRAAAKSSRPIGVILMDQAAISGVGNIFVQNRCTARKLTRYAPGRHSVMMSCAACGTIISTCSPLVCVWVESLPPSSRIVPVSLKLRRGLITQTMCICATGRSARGAVPPSVWKKSLDVNSIGALGARNNSYVRSGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1J3</accession>
    <name>A0A2Z5R1J3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chlorite dismutase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Hemoprotein HemQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_10000</name>
        <name evidence="5" type="ORF">RA11412_2356</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88655">
        <property type="protein sequence ID" value="BAV88655"/>
        <property type="gene ID" value="RA11412_2356"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2356"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="278" mass="31081" checksum="D7904C373DF2755A" modified="2018-10-10" version="1">MSQESHHDAHSHGAPAGGSHAHGGHGPHGAYGDRPAHGYGSQQHSPAEENKRGRENGEKLFYTLYTVFARDGVRPEGASSPAAIAEFEELTQELANDGVTVRGLYDVSAMRNNADVMVWTHGSAPEKLQEAVRKIRRTALFGATTIVWSTMGVHRDAEFTRNHAPAYSRGKAPEAWVCVYPFVRSYDWYYMNPQRRAEMLKNHGMKAIDFPQVLANTVATFGLNDYEWVLALEAPELVDLVDMMRHFRNTEARLYVREEIPFYTGRRIPAADVAEVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1L8</accession>
    <name>A0A2Z5R1L8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6318 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88416">
        <property type="protein sequence ID" value="BAV88416"/>
        <property type="gene ID" value="RA11412_2117"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2117"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046281">
        <property type="entry name" value="DUF6318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19843">
        <property type="entry name" value="DUF6318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6318" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="109" mass="12464" checksum="3ED9712B6A45A32A" modified="2018-10-10" version="1">MNTGDSQHLKDIRFDREDLKSYTDVAELFDDKTWLSEVTVTIELTTSAPIRNTDGYQWPAKLTMKQGDFALIRGKVSQVPQNRKLVQSEGDITGRYVEGSWNLSTPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Q5</accession>
    <name>A0A2Z5R1Q5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88490">
        <property type="protein sequence ID" value="BAV88490"/>
        <property type="gene ID" value="RA11412_2191"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2191"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="110" mass="11323" checksum="9023F9F7BB7E93E4" modified="2018-10-10" version="1">MGSSFSASIGGKLRRTANGDVDVLHALGGWRGVVESLLPATLFLVVFVVTKQLTYALIASLVTSGVFTVARLVQRSKLVPALSGVVGVAVCAWSAHSTGDANAFMFPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1S3</accession>
    <name>A0A2Z5R1S3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88411">
        <property type="protein sequence ID" value="BAV88411"/>
        <property type="gene ID" value="RA11412_2112"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2112"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016380923" evidence="2">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="118" mass="12122" checksum="6102A77A7202CFC4" modified="2018-10-10" version="1">MSRAALTRRTAIAAAGLTSVGVGGAFLLDTINSTSANEQRPQAGSQSLTPAPTQSPGYRGDVKFTSYSGDVEAVVLGNDNAKAKNVPAPQEPHGMTEPNVEGCITSLGSGLLRIITCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1U2</accession>
    <name>A0A2Z5R1U2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MMPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86849">
        <property type="protein sequence ID" value="BAV86849"/>
        <property type="gene ID" value="RA11412_0550"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0550"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="180"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="454" mass="48337" checksum="79AA27EFF8DBA999" modified="2018-10-10" version="1">MAKWLYSIGSFAARKAWAVIAIWVLVIAGVAGTYSAFHGQLKTTFTMPGTETQRLTDELASRFPDANRGTGQVIVTTGDGSRITDEQKQAFVNKLNSLKNENSAVDDVSDPFATEQQIADGKKQLEEGKQKLDAAPKQIEDGKKQLRDAQKKADDGKAQLEAAQKQLDAAREQARAAGALESMREQLGSQQAQIDAQRAQLAESQKQLDTKAAELANSEKKLPEQQAELARKSALLDLTSDYRTVSEDGSTAVAGVFFKMKSSEAPHADKEKLMEHFKNADLKGLTVNFDQNVAESPDVGMGVGEIVGVVVALMTLIVLLGTLIAAGLPILMAIVGVIVGILGTLSFSSLVDMSSTTYMLGMMLGLAVGIDYSLFILNRHRSNLMDGMPLRKSIAVANGTSGNAVVFAGATVIIALLALNVTGIPFLGYMGDAAALCVFVAVLISVTLTPPCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1X6</accession>
    <name>A0A2Z5R1X6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glutamine synthetase</fullName>
            <ecNumber evidence="5">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glnA</name>
        <name evidence="9" type="synonym">glnA1</name>
        <name evidence="8" type="ORF">I6I94_10495</name>
        <name evidence="9" type="ORF">NCTC10207_01500</name>
        <name evidence="7" type="ORF">RA11412_2245</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037234971.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88544">
        <property type="protein sequence ID" value="BAV88544"/>
        <property type="gene ID" value="RA11412_2245"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2245"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="6">
        <location>
            <begin position="104"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="3">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VEI23393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="474" mass="53143" checksum="17D1474D57FB3E8F" modified="2018-10-10" version="1">MFTSPQEVLDFIKDEEIVFVDIRFTDMPGVQQHFNLPAKAVDEDFFIHGQLFDGSSIRGFQGIAESDMQLIPDIDSAYIDPFRMEKTLVIVCSIVNPRTGEPYHRDPRGVAERAEEYLKSTGIADTAFFASEAEFFVFEDVRYQVEPNSVFYTIDSDEAYWNTSRKEEGGNLGNKTPVKGGYFPVSPVDKQADLRDAMCVAMDQVGLEVERSHHEVGSPGQAEINYKFSTLTNAADDLLKFKYVIKNTADEWGKSVTFMPKPVFGDNGSGMHCHQSLWMGGEPLFYDERGYANLSDIARWYIGGLIEHSSAVLAFTNPTVNSYKRLVPGYEAPVNMVYSQGNRSAGIRIPITGANPKAKRLEFRAPDPSCNPYFAFSAQLMAGLDGIRNRIEPPAPIDKDLYELPAEEAKDIKKAPANLEEALAALEADHDFLLEGGVFTEDLIQAWIDYKRTNELEPLSLIPHPLEYQLYYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R205</accession>
    <name>A0A2Z5R205_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88574">
        <property type="protein sequence ID" value="BAV88574"/>
        <property type="gene ID" value="RA11412_2275"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2275"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="166" mass="17347" checksum="ADFDFAF43A92E2DC" modified="2018-10-10" version="1">MRGAVKILSLQTVCARTRWGRRKRAASSQSPDEGSAIVEFLGLGITLLIPIMYGVLTVFSLQASVMAAHSASAQVAQYVRELPKEQSLSQAQANELATLVAQDYGVAASDISVALSCSSSCGSNDTIRVDVSVNARLPLVPIGNGVVPVSSYSMSWGVKSRCASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R214</accession>
    <name>A0A2Z5R214_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DUF3817 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Integral membrane protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I6I94_09405</name>
        <name evidence="12" type="ORF">NCTC10207_01714</name>
        <name evidence="10" type="ORF">RA11412_2498</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88797">
        <property type="protein sequence ID" value="BAV88797"/>
        <property type="gene ID" value="RA11412_2498"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2498"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="9">
        <location>
            <begin position="68"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT88727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VEI23767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="201" mass="21726" checksum="13BB06E7EAD49CE0" modified="2018-10-10" version="1">MSKEHGSETDSAPTPGAPQPVERTDGRKVTLSPNASKAPADGAGHAPQGGFTVRKKFGGTQAQIRSALTFYKWCAWISGTFLLLLVLEMISRYVLGFDLVAGGTEAASGKSVALGVLNRETGNLTGGVNISTLVLIIHGWFYVIYLVSCFRIWLLMRWGIAQFIVMALGGVVPFLSFIVEKRIHAETLAQLDANPQATKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R228</accession>
    <name>A0A2Z5R228_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">groS</name>
        <name evidence="3 6" type="synonym">groES</name>
        <name evidence="6" type="ORF">I6I94_09360</name>
        <name evidence="7" type="ORF">NCTC10207_01729</name>
        <name evidence="5" type="ORF">RA11412_2506</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888719.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88805">
        <property type="protein sequence ID" value="BAV88805"/>
        <property type="gene ID" value="RA11412_2506"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2506"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VEI23794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="95" mass="10308" checksum="A3FA131732C01F26" modified="2018-10-10" version="1">MAIKPLEDRVVVKLEQAEQTTASGLVIPETAKEKPQEARVVAVGPGRIDDKGNRVPVDIAEGDVVVFSRYGGTEVKYQGEEYLILSARDVLAIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R253</accession>
    <name>A0A2Z5R253_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ThrE_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_2341</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88640">
        <property type="protein sequence ID" value="BAV88640"/>
        <property type="gene ID" value="RA11412_2341"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2341"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="142" mass="15334" checksum="39A612C163BF523C" modified="2018-10-10" version="1">MLFAASPVACVWGGVIAAVANPARIWLVEAGWTSHMAATLAVFAVGIMAELVAPLHGRQYSRISLSVPAVVTMVPGVPFYLAMSHMSSGDLYAAMGGFAQSFLTFLALGLGLAFVRLLFDKNWLIDHDTQVLKKLNMNQHMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R257</accession>
    <name>A0A2Z5R257_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Magnesium and cobalt efflux protein CorC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RA11412_2257</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88556">
        <property type="protein sequence ID" value="BAV88556"/>
        <property type="gene ID" value="RA11412_2257"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2257"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="194"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="259"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV88556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="430" mass="46283" checksum="3C71FC915DA53CFC" modified="2018-10-10" version="1">MALESSAVQAARAAGDRKADAVLKCLKTLSTQLSSCQVGITITTLLTGYTLDASINSLASGAVTSLGLPEAVAHALTLILAMGIATLLSMLLGELVPKGLAIAQPYQVARRIAPVQLAFTSLMKPVVLFMNGSANKILNLFGMEAQEELSAARSPEELSAMVRRSAERGTLDSSAARFVDRTLSFSELTASEVMTPRGKVTMLEDTAPVAEVIELARSTGHSRFPLYREDRDNIVGVVHVKKAVGVPAEVRETLEAGTLAEDVLQVPETLHVDALLTQLREGALQLAVVLDEYGGTAGITTLEDLVEEIVGEVSDEHDVGDSTDRPLQYGNGDWVFSGLRRPGEINNYIPELTVEENPEYETVGGFMMERLGRIPDEGDTVPVPGGTLRVDAIDGRRVDRIRFIPDTAQTMYLRTVPARRDRTAAGEKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2C4</accession>
    <name>A0A2Z5R2C4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_2327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88626">
        <property type="protein sequence ID" value="BAV88626"/>
        <property type="gene ID" value="RA11412_2327"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2327"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="136" mass="15729" checksum="707FADAAB056D4D5" modified="2018-10-10" version="1">MGESFDAHPDTLAARLGERALPAELTAQNMVRLFRAYEELKDERNVIDFEDILLLTVGIIEEDEALAATIRQQYRHFVVDEYQDVSPLQQRLLDAWLGERTDICVVGDASQTIYSFTGATSRHLLEFPRRYRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2H7</accession>
    <name>A0A2Z5R2H7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molybdate ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Molybdenum ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">modA</name>
        <name evidence="7" type="ORF">I6I94_08965</name>
        <name evidence="6" type="ORF">RA11412_2604</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88903">
        <property type="protein sequence ID" value="BAV88903"/>
        <property type="gene ID" value="RA11412_2604"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2604"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033776865" evidence="4">
        <location>
            <begin position="36"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="46"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="270" mass="28089" checksum="432687F1988B8DF2" modified="2018-10-10" version="1">MKNSLKAVGVGAALAASLTLAGCGSNANSSSSASADSSAAGSVSGEVKVFAAASLRNAGKDLEAAFKKAHPNVNFSFTYEGSSKLVQKIEQGEDADLLITADKKNMDKAAKLDEFKGSKSEVIATNKLVLVTADGNPGKINSIDDLKNTDGTVAICKEDVPCGTLAHKELKDHNIELKNATNESNVAAVTTKVTSGSADAGFIYTTDLAAAKKDGKNLGSVDLPDVEKNEYPSALTSKGNSSEAAKKFNEWLTTDEAQKILKEHGFESAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2K6</accession>
    <name>A0A2Z5R2K6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">infA</name>
        <name evidence="6" type="ORF">I6I94_09220</name>
        <name evidence="7" type="ORF">NCTC10207_01757</name>
        <name evidence="5" type="ORF">RA11412_2543</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888715.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88842">
        <property type="protein sequence ID" value="BAV88842"/>
        <property type="gene ID" value="RA11412_2543"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2543"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VEI23829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="73" mass="8504" checksum="1AC8B4F615824A0C" modified="2018-10-10" version="1">MAKKDGVIEIEGHVVEALPNAMFRVEMENGHKVLAHISGKMRQHYIRILPEDRVIVELSPYDLSRGRIVYRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2L7</accession>
    <name>A0A2Z5R2L7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08545</name>
        <name evidence="2" type="ORF">RA11412_2706</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89005">
        <property type="protein sequence ID" value="BAV89005"/>
        <property type="gene ID" value="RA11412_2706"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2706"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="478" mass="50785" checksum="32161DA2B630F8E6" modified="2018-10-10" version="1">MTGTQGEGHLTETTAHGWGPAHDRRRTHYLKALELLGNASAITRLGGVRVLAQLADEWLADASIPAPVGREQAQTIVDMLCAYVRLPFPLARNCPQAPASTPERLSDTGMARQHRIDEAEYLAEAQVRSRILAEIRGRVRQPQPLEDAAAGGEATPGPWSGFDFDFSGAEFFDTVDFSGCCWDGRLTFAGSTFCGAASFSNSVYRGQTGVSFEECTYRAGTCPEATAPVGADFSGSYYGGFVSFAGSTYEADACFSGSVYCAGANAQDCTYMADSIFSGCTHYGPVARTGTYGGCVTAADSTFYSSVSFGGEAAGCADFSGCAYYGPAYFRGTFRAEADFGGSIYCEGGRWDSCEFQGQALLGRSLFLGPVSFAEAQLAAGSPVFEQSVVSVFPDAAGCGPTEETPGGARLLTEEETREVTPCARALIEAAAALPQPCVPHDHAAFEPVRDAEEQVRAWFDYFCCTDPLPRTGRNTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Q4</accession>
    <name>A0A2Z5R2Q4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09710</name>
        <name evidence="2" type="ORF">RA11412_2432</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887455.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88731">
        <property type="protein sequence ID" value="BAV88731"/>
        <property type="gene ID" value="RA11412_2432"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2432"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="165" mass="18497" checksum="7F3404830190F80B" modified="2018-10-10" version="1">MSLQKPRRLLKSDNLSDFESGAHDLDSWLHKFAWENQRAHNSVTYVATIGDRVVGYYALAAGSVQKAAVSKNFAQRRPHEIPCILLARLAVDKRTRGQGIGTLLLRDALERTVSASETLGVAALLIHCRDEEAKKFYEYHADVLESPLDPFQLILPMKSIRKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2R7</accession>
    <name>A0A2Z5R2R7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sucrose-specific IIB component protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RA11412_2613</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88912">
        <property type="protein sequence ID" value="BAV88912"/>
        <property type="gene ID" value="RA11412_2613"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2613"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="119"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV88912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="393" mass="41737" checksum="83F07C968F3005CA" modified="2018-10-10" version="1">MDHKSVAERVLQDVGGVGNIRAAAHCATRLRLVLKNQDSVDQSAIDNDEDLKGSFLNAGQFQIIVGPGDVNEVFKHMVASGAPEVSKDDLKSIAANQGNIFSRFIKTIADIFIPLIPVLVGGGMLMALDNVLRAKNIFGPKPLIEMYPAWEGFADIVNLLSAAPFAFLPVLVGYSATKVFGGNPYLGLTMGAAMVSPALMNGYKVAASLAHTEGADPMKYWDLFGLQVQQAGYQGTVLPILLVSFILANIEKFFHKILKGTIDFIFTPTLTLLITGFVTFLLVGPPMFQLGTWLGEGVNWLYTAAGPIGGLIFGVLYAPIVITGLHQSFPPIETSLWASGGSFIFVIASISNVAQGAAAAGVALTTKNKKIKGVASASAPSAFWVLPNPHFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2U3</accession>
    <name>A0A2Z5R2U3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flp pilus assembly complex ATPase component TadA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Flp pilus assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tadA</name>
        <name evidence="4" type="ORF">I6I94_04390</name>
        <name evidence="3" type="ORF">RA11412_0910</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87209">
        <property type="protein sequence ID" value="BAV87209"/>
        <property type="gene ID" value="RA11412_0910"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0910"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="11"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT90097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="357" mass="37963" checksum="36487A97F717736F" modified="2018-10-10" version="1">MGALENLTGIPHLSDIYVNGPADIWVQAAGQTQPTALTLGNEARVRSLAQRLIRASGGRLDAAHPAADVQDTHGRRIHAVIPPLVPRTHLSVRVAASRRQTLEDLEKTGMFDAGTAAELRSIIAEKKSFIISGGTGTGKTTLLNAMLALCPANERLLTLEDTPELAPSHPHVVAMMTRAANTEGTGEINLGELIVQALRMAPDRLIVGECRGAEITHLLTAMNTGHTGAGTSLHANSARAVPMRLAALGALAGLDARTVALHAATAFDRIIHLQKDGPTRRVEGIYELALDREELTVRPVPSHAVPKIQLSEFELPQYTPVGIPSPAGADTTPHLKLATAEDLAPSEPVMERRLYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2V9</accession>
    <name>A0A2Z5R2V9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89097">
        <property type="protein sequence ID" value="BAV89097"/>
        <property type="gene ID" value="RA11412_2798"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2798"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH" evidence="4">
        <location>
            <begin position="429"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV89097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="591" mass="65799" checksum="7AB45EC652CF66E2" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R348</accession>
    <name>A0A2Z5R348_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">greA</name>
        <name evidence="11" type="ORF">I6I94_03835</name>
        <name evidence="12" type="ORF">NCTC10207_00505</name>
        <name evidence="10" type="ORF">RA11412_1050</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888257.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87349">
        <property type="protein sequence ID" value="BAV87349"/>
        <property type="gene ID" value="RA11412_1050"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1050"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="9">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="8">
        <location>
            <begin position="86"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VEI22429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="167" mass="18114" checksum="88B2A9E5689334CA" modified="2018-10-10" version="1">MAATENNGAWLTQDAYDRLKEELDHLSGPYRQEIVERIAAARDEGDLRENGGYHAARDEQGKNEARIKQLTHLLENANVGEAPSDDGVVALGMVIEAEIAGRPMKFLLGSREVESTLPEGSDLKVFSEKSPMGAAILGHKQGEEVTYQAPNGNDLVAKIISVTPFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R354</accession>
    <name>A0A2Z5R354_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">nusG</name>
        <name evidence="11" type="ORF">I6I94_08880</name>
        <name evidence="10" type="ORF">RA11412_2622</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88921">
        <property type="protein sequence ID" value="BAV88921"/>
        <property type="gene ID" value="RA11412_2622"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2622"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="8">
        <location>
            <begin position="77"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT88626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="260" mass="29176" checksum="820116DEE6143C5E" modified="2018-10-10" version="1">MPEKDMVSEVEEVEVEPAEAETFEDEVEEIGSIAADEQPAADTAEQEPETEESQSSAEAAAAADPLEEFKAKLRRQIGDWYVVHTYSGYENKVKAGIETRIQNLEAEDEVFEVQVPMETVVEYKNTVKKTIRRVRVPGYVLVRMDLTDHSWGVVRHTPGVTGFVGQDAYNPMPLRMDEVFDMLLPVFEEEQQSKGLPTPQPVVESDYSVGDNVRVKSGPFEGMDATISEIKPEAQEVVTLISVFERDTPVTLKFSQIEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R382</accession>
    <name>A0A2Z5R382_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89054">
        <property type="protein sequence ID" value="BAV89054"/>
        <property type="gene ID" value="RA11412_2755"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2755"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4723" checksum="0803E641ED0BB47E" modified="2018-10-10" version="1">MINNTVIENLQKHYGISQDRRLDGPSQTIKALQNEINQWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R390</accession>
    <name>A0A2Z5R390_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89080">
        <property type="protein sequence ID" value="BAV89080"/>
        <property type="gene ID" value="RA11412_2781"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2781"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="83" mass="8908" checksum="EC441D7D00C59F38" modified="2018-10-10" version="1">MKEDGTKIAVDYDGSWTMDKPDGTHIVVKHDGSWTMKDPSGKVTAVEYDGTPSPKDGTVVAPQVPAKPNTDVKDPRTPISPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3B7</accession>
    <name>A0A2Z5R3B7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08350</name>
        <name evidence="2" type="ORF">RA11412_2752</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89051">
        <property type="protein sequence ID" value="BAV89051"/>
        <property type="gene ID" value="RA11412_2752"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2752"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340111" evidence="1">
        <location>
            <begin position="42"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="169" mass="17970" checksum="B3762F736C72B918" modified="2018-10-10" version="1">MTADNKGLSRRKLLKAGAIGVPAAGVLAFGSTLVTATSANAISTDGWWGSETSAGFQRFMNAALGANLVVDGWISSQPAAMAPYCPGIVGGWEWAIQIDQGSPTISKMSEWLGMQWKGADGSSYSYPYPHFSSTHVNKLQSHYGIAQDGRLDGPSKTIQALQNEINQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3C4</accession>
    <name>A0A2Z5R3C4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87509">
        <property type="protein sequence ID" value="BAV87509"/>
        <property type="gene ID" value="RA11412_1210"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1210"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="266" mass="28822" checksum="065CBC486AC89E79" modified="2018-10-10" version="1">MSVIDAGKVFSTLGINQVKDEIQIAKHELKTKGIAVGKGAAFLAIAAFFAALFIIAIVGAIILGLGEIMRPWLAALVVALIFAIVILITGLIGYKKVKAQMPFAPESAVFGLLFDLGVLREGSAMTASRLKKEQAERAARKQAEREAAAEQARQEAEERKARGESEPQPLTEEQLRQRTKERREHLAALRDDMQKYSEGVQANAQGIIGSAKAKAQQAPTEAVNVGRGLAENITQPNVVKARWKSFAALGAALPAALVFLRRFLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4Z2</accession>
    <name>A0A2Z5R4Z2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88999">
        <property type="protein sequence ID" value="BAV88999"/>
        <property type="gene ID" value="RA11412_2700"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2700"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="80" mass="8381" checksum="87C2137EBA27C9FF" modified="2018-10-10" version="1">MVRARDTMEAAIEAIRTSAIDQSNPSTTASMFQLPYSPGTTRILLDRLAFLDGGSDAAAQPDASGFTGPITIGKAHSGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVA2</accession>
    <name>A0A2Z5QVA2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gpmA</name>
        <name evidence="7" type="ORF">RA11412_0014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="BAV86313"/>
        <property type="gene ID" value="RA11412_0014"/>
    </dbReference>
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        <property type="reaction ID" value="UER00186"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="His_Pase_superF_clade-1"/>
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        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
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    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="115"/>
            <end position="116"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
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    <feature type="region of interest" description="Substrate binding" evidence="4">
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            <begin position="182"/>
            <end position="183"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
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    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="10"/>
        </location>
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    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="181"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV86313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="252" mass="29056" checksum="3FB94355EF5E75DC" modified="2018-10-10" version="1">MTYKLVLLRHGQSEWNEKNLFTGWVDVNLTDKGRAEAQRGGELLKERHILPDVVHTSLQRRAINTANISLDAADRLWIPVKRTWRLNERHYGALQGKNKSEIREEYGDEKFMTWRRSYDVPPPPLDDNDPYSQANDPRYADVENAPRTECLKDVLGRMLPYWESDIKPDLAEGKTVLVAAHGNSLRSLVKHLENISDEDIAGLNIPTGIPLYYELDENFKPVKPGEYLDPKPRRMRLRPSPTRVSKFSPTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVI2</accession>
    <name>A0A2Z5QVI2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA starvation/stationary phase protection protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Iron-binding ferritin-like antioxidant protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_07755</name>
        <name evidence="4" type="ORF">RA11412_0104</name>
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    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="166" mass="18438" checksum="3FD7F7ED07F01DFF" modified="2018-10-10" version="1">MAFAKYTAPGLTLDEGKEISEVLQSRLHDLNELHLSLKHAHWNVTGPGFIAVHEMIDPQVDTVRNFVDDIAERMATLGATPNGLAGALVAARSHDDYPVGRARVTDHLHALNEVYTRVIEDHRKAIEFAGKVDPITEDLLIGQTAELEKFQWFIRAFLENSAGEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVI7</accession>
    <name>A0A2Z5QVI7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86407">
        <property type="protein sequence ID" value="BAV86407"/>
        <property type="gene ID" value="RA11412_0108"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0108"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="52" mass="6179" checksum="7FE516CD2684DF82" modified="2018-10-10" version="1">MLCEEIARLVFEKVHRCPSSSKWCRRFRVRRLGLVSYYSTCFTPLRGRAVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVJ4</accession>
    <name>A0A2Z5QVJ4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SagA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86417">
        <property type="protein sequence ID" value="BAV86417"/>
        <property type="gene ID" value="RA11412_0118"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0118"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="4025" checksum="CA273DCDBFC40C47" modified="2018-10-10" version="1">MGIYVGNGMMISALNPSQGTQLHPVSWMSVDGYYTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVM7</accession>
    <name>A0A2Z5QVM7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86448">
        <property type="protein sequence ID" value="BAV86448"/>
        <property type="gene ID" value="RA11412_0149"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0149"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="111" mass="11364" checksum="951B02BCF149F40E" modified="2018-10-10" version="1">MPNTTSKSSENNAPDAPAHSDQNAKSIGSRNSFLSIGSVNSFCSIGSVNSAFSIGSAFSFGSIGSAFSSLSVASCLSYMSVLSVLSEASVLSARSYRSVLNAGQQKKAKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVQ9</accession>
    <name>A0A2Z5QVQ9_9MICC</name>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
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    <name>A0A2Z5QVR2_9MICC</name>
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        </submittedName>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
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    <name>A0A2Z5QVS1_9MICC</name>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
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                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86480">
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        <property type="gene ID" value="RA11412_0181"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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            <end position="250"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88375.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="250" mass="27840" checksum="372AFB3AADFBB241" modified="2018-10-10" version="1">MSENNTPGTGTNRPGTPPPARRENKTQSRYGLRFDQMDPEELEYYRPFWDAPENTREHTVPDEVSAVLAVRARRRLFNMMGLMILAVGLAIAGAGLFASALPATFAGTLLSLAGVGCWVAVRRRLFAVLRAPGEEAVQQGEHSRWWLLPHLITVFGVGAVIASFTVVPVLYANTGEDLRRNYTVMWAEIGMTALIFAGLAYGMLALAAYTQKDEDERVLRPTDYAERQGTEPQIPRYRPGMLNPRDDDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVS8</accession>
    <name>A0A2Z5QVS8_9MICC</name>
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        <submittedName>
            <fullName evidence="5">EamA family transporter</fullName>
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    </protein>
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        <name evidence="4" type="ORF">RA11412_0208</name>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 6">JCM 11412</strain>
        </source>
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    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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        </location>
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        </location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86507.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QQT88360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="343" mass="36449" checksum="FAB81E3CD4108679" modified="2018-10-10" version="1">MTPGTTRHKRPTVGIIFVIISCLSLQFGAAFAVHLFPLFGPWLVTVLRLLLAAITVGAAVWIAGRWRAHRAGAQTAYMAVPAKTSDGFLGWSSRQWRAMLIFGVTLGLMNGFFYNALARIPLGLAVAVEFTGPLVLASILTRRKRDLVWVFCAAAGMAVLGFEAVHGQETDLLGVLYALIAGAFWALYIRSSASVGELVPGASGLAVAMAVGAICVVPEALLFPGPVALWSVTHDTQLVLFIIGTSLLASVVPYSSELAALRHLPEQVFSVLLSLEPVIAALAGWALLGQETGLMRWVAIILLITASIGITQTTGGSVPADETSDSYRRNEPPEHTSPLPLPE</sequence>
</entry>
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    <accession>A0A2Z5QVY8</accession>
    <name>A0A2Z5QVY8_9MICC</name>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT88306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037236367.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86550">
        <property type="protein sequence ID" value="BAV86550"/>
        <property type="gene ID" value="RA11412_0251"/>
    </dbReference>
    <dbReference type="GeneID" id="32322164"/>
    <dbReference type="KEGG" id="raj:RA11412_0251"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="312" mass="36194" checksum="8D9D0DA488DF9DFC" modified="2018-10-10" version="1">MSKKPTAAMKHNLDRLVENITTGDDSEDYQRERGYLDEYIRQGTTPFTHRWYDDFLEKDCEVSYTATQVIYDLRMELCIPLAEFLQAPSESLFRAMMAKAYFLTMGYVRHHLTGRPRIPYISVNNSYFAFLASLFFSRDEQSLSFAALQTIIANPDECIRPQETDAARTLIPLSFRLAQDHLALPIDQTQADLFAFSELYQTAYAGFDSSDAEQVKQIFNDLADYHIRQSRDDEKGYPEFEYTLEQWMPWEILALLRLRTQKGLDNSMISHPLITPFLPFVGLELGGFFDDAQKNLRRAVFKEFGYQPVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW53</accession>
    <name>A0A2Z5QW53_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06825</name>
        <name evidence="2" type="ORF">RA11412_0311</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86610">
        <property type="protein sequence ID" value="BAV86610"/>
        <property type="gene ID" value="RA11412_0311"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0311"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="398" mass="44854" checksum="3E194CE232727C6E" modified="2018-10-10" version="1">MTNTEKNDWDLRSEKVQKNQVAAYDEMRRRCPVAHDEFMGYSVFKNADVQHVLDHPDIYSNVVSTRHIAVPNGMDAPEHTTFRAVNDKYFTPERLREFEPKIREVVKNLVADLPRGTEVNVMDGFAQAYAMRIQNAFMGWPASLEKPLIEWIEKNREATLRRDREQIGKVALEFDTYIRELLDARREQAAAGNPQDVTAELLTDTVQLPGHKPRTMTDEEIVSLIRNWTVGELSTVSACAGIIVNFLARNPQEQARLRDSLGEGHAEIAAAVEEIMRLEDPLVTNRRVTTEDTVLGGRTIPANSRVTINWSSANRDEDAFEDALAYNPHRDQSRNLVYGDGIHVCPGAPLARLELRLLMEELLKATKSIVPGDESDVPATENATYPISGYSTVRVVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW54</accession>
    <name>A0A2Z5QW54_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II restriction enzyme MjaIII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="162569">
        <property type="entry name" value="Rae11412ORF223P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86524">
        <property type="protein sequence ID" value="BAV86524"/>
        <property type="gene ID" value="RA11412_0225"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0225"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009036">
        <property type="term" value="F:type II site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007637">
        <property type="entry name" value="Restrct_endonuc_II_DpnII-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04556">
        <property type="entry name" value="DpnII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DpnII" evidence="1">
        <location>
            <begin position="2"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="181" mass="20888" checksum="F70EE195D6A6A6E8" modified="2018-10-10" version="1">MIGLNNLYEEAIQLFTQQPNLLEAVPVLFASRDVHLDVMEVDEDESIFFYNLDFKNVDTTNIQKYVDFMQKSGLLDFLKHSANRSLVDYAYGVEVGLDSNGRKNRSGKVMEDLLEGQLRAVADFYGYQTMTQATAHRMRQEWQVEVPVDKSERKFDGALFDSHKRRLFSSKQTTMEVEAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW68</accession>
    <name>A0A2Z5QW68_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86655">
        <property type="protein sequence ID" value="BAV86655"/>
        <property type="gene ID" value="RA11412_0356"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0356"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="66" mass="6923" checksum="04138BD2F78417CA" modified="2018-10-10" version="1">MSQQAPLTQYQQQQPSLQEQIPPQQVGAPGPVLPVSEPQPSVADGASGAFAPQYPQAFEPQPSAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWI8</accession>
    <name>A0A2Z5QWI8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86751">
        <property type="protein sequence ID" value="BAV86751"/>
        <property type="gene ID" value="RA11412_0452"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0452"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="140" mass="15312" checksum="0EBD212D7E9C6335" modified="2018-10-10" version="1">MGGDFSTSLRRQTGSQWGKRILGGMALTTAAYLGVQGIRCYRAVHKAAAKLASYPVQVAHLNYGEMAYLNIPPATTCANTSAPIILSLHGLYGGYDQATENVKDFSKPYRIIAPSRFGYPGSSISKTELRRNRPPHFLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWJ1</accession>
    <name>A0A2Z5QWJ1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86594">
        <property type="protein sequence ID" value="BAV86594"/>
        <property type="gene ID" value="RA11412_0295"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0295"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="423" mass="46481" checksum="900AD4990462F9E2" modified="2018-10-10" version="1">MPWSSSNTAAQSAESTASGSGSEQDPVQAAPVSPGDDPRPVSQLLALPPLTDAIKQVSKNPENPPAHGSYAVPVYNLDPSLTSDMSASVERTLPYHRLAFADGRSRWFTPLLEGLVALVVYVVLITLFTVVMMSIPLIIRADKTTDFGTYIRDDVLNDPLAMFFVFGSVALMFPAIRVARLIFGPRPWGLVHSVQRRVRWSLLLTALVVGAFCYGLLSLLTLMLDGFSSIGFHHKQPHEVAFWLNMVLLLVLVPLQCYAEELVFRGYLMQTIGRWLKNPAWAILLPAPFFMLAHGYDLWGQASIVVMAVLAGFLCWYTGGLEAAIGMHVMNNITTMAMGMFANTDPLQMQSSGTPTDFAMVLATEVLYTAAICWFTHYRGYLRTATFTVQDPKQSHAPVQFSPAQASQGHSPQSPEQPKQQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWL4</accession>
    <name>A0A2Z5QWL4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF3566 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_06120</name>
        <name evidence="4" type="ORF">RA11412_0487</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86786">
        <property type="protein sequence ID" value="BAV86786"/>
        <property type="gene ID" value="RA11412_0487"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0487"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021949">
        <property type="entry name" value="DUF3566_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12089">
        <property type="entry name" value="DUF3566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3566" evidence="3">
        <location>
            <begin position="66"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="184" mass="19726" checksum="4C52E7BB67A03321" modified="2018-10-10" version="1">MSMNPQGRVQVGQGARRQAPARRAAPANRPGARSGSNQRRPRRSAPPQQQQGRRKRQNLVRRTKVRRADLVIAKVDTWSVAKLVFLLSIAVGIVTVVASMILWLFLQATGAFNGLNQLLSSLGTGGNSSIDIAQMVSLGQVALATTVIAVINTVIFTLLGMISAILYNLAAKLVGGITLTMKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWQ3</accession>
    <name>A0A2Z5QWQ3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_05860</name>
        <name evidence="3" type="ORF">RA11412_0549</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86848">
        <property type="protein sequence ID" value="BAV86848"/>
        <property type="gene ID" value="RA11412_0549"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0549"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="217" mass="24281" checksum="ECEAA3267483EB63" modified="2018-10-10" version="1">MCIAQKIVDKRSARKAENRIAIMDAAEKLVLAGGLKALTADTLAKESGVSRRTIFNHFSSVEAAAVERLNEYLDRIFEVIPDFCTPTGPHLERDMLDGVRAAFTTERLAEHVEPHARLLFALHDYSVDNKFNEYSSTSYLNSIEMVVDKLWQQRQDIPRMRIAIFGNLIASAVCEGIAASFYDAEGNPQPPEDAEKMRDSIEHCLGYVEKLLGGQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWV6</accession>
    <name>A0A2Z5QWV6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">pyrE</name>
        <name evidence="7" type="ORF">I6I94_05585</name>
        <name evidence="8" type="ORF">NCTC10207_00116</name>
        <name evidence="6" type="ORF">RA11412_0626</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013398063.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86925">
        <property type="protein sequence ID" value="BAV86925"/>
        <property type="gene ID" value="RA11412_0626"/>
    </dbReference>
    <dbReference type="GeneID" id="29742611"/>
    <dbReference type="KEGG" id="raj:RA11412_0626"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="120"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="133"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI22050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="193" mass="20603" checksum="05BABC4153E9BB3C" modified="2018-10-10" version="1">MTKLSETLPIEEARERLRQLISELAVVRGKVTLASGKEADYYVDLRRITLHHEASRLVGQVMLDLLDRNGIEFEAAGGLTMGADPVGSAIMRAAGDQDRAIDSFVVRKAQKSYGMGRQVEGPSVEGRRVVAVEDTSTTGGSALTAVDALRTAGAEVVAVAVIVDRATGAKEHIEEVAGVPCFYAYSKDDLGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWW7</accession>
    <name>A0A2Z5QWW7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86833">
        <property type="protein sequence ID" value="BAV86833"/>
        <property type="gene ID" value="RA11412_0534"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0534"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="129" mass="13788" checksum="2BD8D518CE18DFCF" modified="2018-10-10" version="1">MGQKTTTLYADGSWEEKETKSGGEEAVTHVNPDGTWRTTEGSKKEELHADGTWRSESSGGFVTYSDVNGKVYMEGSSGKPFEITNETYTTVRTPSVPSPRVGYGLGIGGGGVLPLTPRKPLYPGQQAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWZ5</accession>
    <name>A0A2Z5QWZ5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_05645</name>
        <name evidence="1" type="ORF">RA11412_0611</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86910">
        <property type="protein sequence ID" value="BAV86910"/>
        <property type="gene ID" value="RA11412_0611"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0611"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="180" mass="20380" checksum="A92E6AEBEA46A631" modified="2018-10-10" version="1">MPKSLATEEFITGVLHDTERRIREQIDRGEITPTAESMQELSNALSHTVEVRKGARGSGKYIGKVKDSRSTREYLGGISLQALNDRVRKNNILRLKNKAGRNGYPVFQFKDGAVDPQVRQIIKTLLDGKLTEWEVAFWLAVPSNFFDGRPAVEYMKDSEENFKFVLACAVQDAADRRANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX36</accession>
    <name>A0A2Z5QX36_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86886">
        <property type="protein sequence ID" value="BAV86886"/>
        <property type="gene ID" value="RA11412_0587"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0587"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="162" mass="18157" checksum="1989BD278C7ADCDA" modified="2018-10-10" version="1">MAARRQTANPTSPLPAPKFWGFQSLLPYKAVNGLRHPGELPWLIAAYSFTLISYIGLIVFIIESFLLVIDSRDSLRDFGDYPRTGSAEYYMQEYLQQFVVLLVLGPLLIYIARAILYAQQRVRGIRMSPTQFPEGTRWSLRPPVPPACAASPTPTLLAATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX82</accession>
    <name>A0A2Z5QX82_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2,3-butanediol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_05330</name>
        <name evidence="4" type="ORF">RA11412_0682</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888352.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86981">
        <property type="protein sequence ID" value="BAV86981"/>
        <property type="gene ID" value="RA11412_0682"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0682"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT90009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="361" mass="38825" checksum="822F2560B4A75254" modified="2018-10-10" version="1">MKAARFYDRNDIRIEDIPAPKVAPGEVLVKVAWCGICGTDLHEYLDGPIFCPQHGHPHPISGEDSPVTMGHEFSGVVKELGEGVTDLEVGDHVVVEPYIIDDAVDVGPDSKTYHLSKNMNFIGLAGRGGGLSEVVSVKRRWVHKISKNIPLDEAALIEPLTVGVHAVERAGEIHEGDYALVTGAGPIGLLTSAVLKAKGAKVIISELSPLRRQKALDSGVADYTFSPAETDVLAEIQKLTNDRGVDIAFECTSVQPALDLILDAIKPTGKVVVVSIWGKPASLDVQKLVLKEIDLRGTIAYVNNHPESIALVESGKLDLKPFITGKIALEDLIDKGFDTLINHNETAVKILVTTDPELLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX89</accession>
    <name>A0A2Z5QX89_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">APC family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_05060</name>
        <name evidence="3" type="ORF">RA11412_0743</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87042">
        <property type="protein sequence ID" value="BAV87042"/>
        <property type="gene ID" value="RA11412_0743"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0743"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="845" mass="88291" checksum="CC41174B1AFCF58C" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXD3</accession>
    <name>A0A2Z5QXD3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">L-proline glycine betaine ABC transport system permease protein ProV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_04770</name>
        <name evidence="5" type="ORF">RA11412_0808</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87107">
        <property type="protein sequence ID" value="BAV87107"/>
        <property type="gene ID" value="RA11412_0808"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0808"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="23"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="301" mass="32137" checksum="842A34FF7926C2A5" modified="2018-10-10" version="1">MPASTPQDTIPSNSAQAACTAGIEFSQVTKRYGANTVVNNLTLSIPAGETTVFVGSSGCGKTTTLRMINRMVEPQEGTITIGGQNIADQDPYKLRRSIGYVMQSGGLLPHRTVLENVMTVPLLNGTPKPQAKERALDLLGTVGLDASLAQRYPAQLSGGQAQRVGVARALAADASILLMDEPFSAVDPIVRTELQEELLRLQGELHKTIVFVTHDIDEALFLGDNIAVFAPGGKLAQYGAPEEILTNPANDFVESFVSQSVGALLPADVMRQVRYIRRERYRRTREAAASGEGAASTSGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXK1</accession>
    <name>A0A2Z5QXK1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87185">
        <property type="protein sequence ID" value="BAV87185"/>
        <property type="gene ID" value="RA11412_0886"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0886"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016317697" evidence="2">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="62" mass="6227" checksum="47516BF04D547723" modified="2018-10-10" version="1">MFKPHGAHRARMLGVAALSVCTALLGTPATLAAPAQPAPASAGPATQDTVEGLGRVRWSPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXK4</accession>
    <name>A0A2Z5QXK4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Guanine/hypoxanthine permease pbuG</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">NCS2 family permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Xanthine/uracil/thiamine/ascorbate permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pbuG</name>
        <name evidence="8" type="ORF">I6I94_04810</name>
        <name evidence="9" type="ORF">NCTC10207_00279</name>
        <name evidence="7" type="ORF">RA11412_0802</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87101">
        <property type="protein sequence ID" value="BAV87101"/>
        <property type="gene ID" value="RA11412_0802"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0802"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAV87101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89913.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VEI22210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="489" mass="50278" checksum="A4727AC51BB9AFB7" modified="2018-10-10" version="1">MSSENTAAPQAHKPNASGGALDRYFKITERGSSISAEIRGGLAAFFAMSYIVVLNPLVIGTGADSAGNTLGVPQVAAVTALVAGVMTILMGVIAKQPFAMAAGLGVNALLASTIATTPGLTWADIMGLVIIAGLIMTVLVLTGFRTAVFEAVPESLKTAIVAGIGFFIAFIGLVDSGIIRRMPDAAGTTVPVSLGVGGHLLGWPTLVFIFGLFLTIALFIRNVRGAILIGVVASTVLAIILEAVFHIGSSKGNPTGWSLNVPALNNFSFSAPDFSLIGSARFGAFGAIGVLGASLLVFAILLSVFFDAMGVSVGLATEAGTIDKDGKVENINEVLLVDAVGSVVGGGASGSANQIFVESATGIGEGARTGLANIVTGVLFLVAIIASPLVTIVPFEAVAPALVVVGFLMVRQAVHIDWQDWGLGIPAFMTIIFMPLSYSIANGIGAGFVSYAFIRLVQGRGREVHWLMYVVSAVFVIYFGMGIINGFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXP5</accession>
    <name>A0A2Z5QXP5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lanthionine synthetase C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0797</name>
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    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87096">
        <property type="protein sequence ID" value="BAV87096"/>
        <property type="gene ID" value="RA11412_0797"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="335" mass="36004" checksum="F5FDFCFF274392B1" modified="2018-10-10" version="1">MALAQAAHTLGNAEYAQAAHRVLDPIAQDVFDKRLFSIPPETCDGVSGGEAGIALSLASAAEYLDDPRLKEAAIMLGDRVAARMEQVEHPMPGYLDNQVGAATLLLGYNLATNRAALLEVLEKHALDIVAGRVEENWWNVSGFAYGVSGSIFALARWGQEMPTPGRAQHAVKILLQRLNSFRCAEGWRAQLSERSGTGDAHTGGTWCSGSAGIALALAAVHVWMPEFSPRTELDRAVQYAFRTGTRSNLTLCHGDLGTLEVLNWIIARVPDVPDAEDIRAAVKNGYGPSVIRATLDDKSSRYSLTPSLLVGTSGVLSWLAHRLGEGVYTPPSFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXU5</accession>
    <name>A0A2Z5QXU5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87262">
        <property type="protein sequence ID" value="BAV87262"/>
        <property type="gene ID" value="RA11412_0963"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0963"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="66" mass="7791" checksum="0B2DFE94FE044747" modified="2018-10-10" version="1">MIVEFDGRVKQTSRVMNPDGWAIDREKERENALMRAGWRLIRLRWEHVNGGNPKVLEQSLRNFGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXY9</accession>
    <name>A0A2Z5QXY9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase hydrophobic membrane anchor protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase hydrophobic membrane anchor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_03935</name>
        <name evidence="8" type="ORF">RA11412_1026</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037232601.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87325">
        <property type="protein sequence ID" value="BAV87325"/>
        <property type="gene ID" value="RA11412_1026"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1026"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="161" mass="18061" checksum="36BBD431B3ABC901" modified="2018-10-10" version="1">MATPLKSRVAIPRIRDNKIDGVKYNRSSSKRNNFEMFAWLGMRLSGVLLVVLIFGHLFVNLMVGEGIHAIDFGFVGGKWANPFWQVWDLLLLWLAMLHGANGIRVVIDDYAEKDRVRVWLKIILFLASAFVLLVGTLTIFTFDPCPSGAASHLLPSFCAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY26</accession>
    <name>A0A2Z5QY26_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87243">
        <property type="protein sequence ID" value="BAV87243"/>
        <property type="gene ID" value="RA11412_0944"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0944"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="896"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="924" mass="105572" checksum="5B10C28A44FF5038" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY58</accession>
    <name>A0A2Z5QY58_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative deoxyribonuclease YcfH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87382">
        <property type="protein sequence ID" value="BAV87382"/>
        <property type="gene ID" value="RA11412_1083"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1083"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="278" mass="30653" checksum="6C7B1BDF77DF483F" modified="2018-10-10" version="1">MFPPAPEPLPYAIVDNHTHMDLLDGEVEITARDALDTGEKLGIGAIVQVGCDIPSSLYAVAAARADRRVLAAIAIHPNTAPELDSAGTLDEALETLDALAAEPRVRAIGETGLDYFRTGEEGIEAQQRSFREHIRLAKKHGLALQIHDRQAHDDVVSLLLEEGAPEHTVFHCYSGGAELARICNEQGWYMSFAGTVTFKNSKDIQESLRMARPELILAETDAPFLTPHPFRGRPNASYMTNYTVRFMAAHREQNLEDLCQMIRANSARVYGSWGIEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY66</accession>
    <name>A0A2Z5QY66_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_04515</name>
        <name evidence="2" type="ORF">RA11412_0875</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87174">
        <property type="protein sequence ID" value="BAV87174"/>
        <property type="gene ID" value="RA11412_0875"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0875"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="359" mass="38734" checksum="EA69C4E1E4E15AB3" modified="2018-10-10" version="1">MPAETTAKREAGVDLARAFALLLLVMPVSVALNLVPENRLHWLGSVPPAANTLLAALLGISAYLYARRVTFPQFFASTVVRAIAFFVLGWLLAQGRAYQPMAAHAEFPILYDLLIPFAVLTLLTTLFVYSPLWVQAALTALASPAIPFTYEQLVNRGWAADDWLSRTIPALFNEYTGTVLHSGLKMLWQVGLGILLWRAYEKLGPKIGVPVGLLGLGAAVLFWVNPKAQSGVLAWPTTLSIVGVAGVLYVCAEAARVLAGRGAILEPFARVGRMSLSASIVILLAAVHGGTYLVQLVAGAEYRAPLEGTWLTYLYWVGFLALAWGAGALFTWLWQKLLSNSTLSRGPIECVLALMSGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYA2</accession>
    <name>A0A2Z5QYA2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87290">
        <property type="protein sequence ID" value="BAV87290"/>
        <property type="gene ID" value="RA11412_0991"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0991"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="4217" checksum="48811E736748EDB5" modified="2018-10-10" version="1">MPRFLARRVPWLDFRGVRGFRPSACTVESVLGLLPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYC1</accession>
    <name>A0A2Z5QYC1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GAR transformylase</fullName>
            <shortName evidence="2">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purN</name>
        <name evidence="5" type="ORF">I6I94_04000</name>
        <name evidence="4" type="ORF">RA11412_1011</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87310">
        <property type="protein sequence ID" value="BAV87310"/>
        <property type="gene ID" value="RA11412_1011"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1011"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="3">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="2">
        <location>
            <begin position="6"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="2">
        <location>
            <begin position="83"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT90087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="187" mass="19996" checksum="9E628DA49F0BB806" modified="2018-10-10" version="1">MVSGSGTNLQAILDAVKAGELNAEIAAVGADKPCTGLDRAAAAGVETFLIEPADYADREQWNRALEEKIASYTPDYVVFAGFMRIVDAQLVARFENRIINTHPALLPAFPGAHGVRDALAHGVKITGLTVHFVDSGVDTGTIIAQAAVPVEAGDTEESLHERIKVQERWLLVRTLAEFAALPNPQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYD4</accession>
    <name>A0A2Z5QYD4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="4">4.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NCTC10207_00515</name>
        <name evidence="3" type="ORF">RA11412_1064</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87363">
        <property type="protein sequence ID" value="BAV87363"/>
        <property type="gene ID" value="RA11412_1064"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1064"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI22439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <sequence length="251" mass="27026" checksum="BAE3D1BA9D8C40F9" modified="2018-10-10" version="1">MGSLKDQVQPSPAQAWKRLKDGNQRFVEGISEHPNQDSSRRTLLSGGQFPFACIFGCGDSRLAAEIIFDLGLGDAFVVRTAGQVIENGVLGSIEYAVEEFKTPIIMVLGHDSCGAVTAARNAAQTGDMPPGFIRNLVERILPSVIAPSLPPHAHVNDMVREHTRQTAMRITEQSHIVSDAVLSGEVAVIGVFYHLRDGKAELVFSSQDLTLPNTPTGEGQSPTTASLPVSVKQQPRIVFAETWGEASPWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYH7</accession>
    <name>A0A2Z5QYH7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87294">
        <property type="protein sequence ID" value="BAV87294"/>
        <property type="gene ID" value="RA11412_0995"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0995"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="338" mass="35236" checksum="B3696297B1EB9D48" modified="2018-10-10" version="1">MASENWLSEDFYKTLGVKEDASDSDIKKAYRKLSRKYHPDLNPGNETAEKKFKEVSEAYDVLSDKKQREEYDQIRKYGAAGFGGSGFGGGASGFGGAGGGFGGQNVHFTTGGGGEGINIEDLLGGLFGGGAGGAGGSRRTAGFTSADFSDAGFGGGGFGGGGRKRAPQDNNLSTSTRITLPQSYTGTTATVFLPDGTSTEARIPAGVKDGQKVRVRGKGRPGTGGDLIVTVRVSDDPHYSREGNNLVLRAPVTLDEAVNGGVLEVPVPGGKTVKLRLTPGSVGRKLRAKGRGFTTKSGTGDLLVIPEVHLPQNLSDEAKEAFEKFIALAPQENPVRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYI1</accession>
    <name>A0A2Z5QYI1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87512">
        <property type="protein sequence ID" value="BAV87512"/>
        <property type="gene ID" value="RA11412_1213"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1213"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="340" mass="37764" checksum="A5BC6C7C7881E25A" modified="2018-10-10" version="1">MMSDNLPQQPGHNGYDQQDHTQPYGISQQQGQQNTPYQQNQYQQNPQQGMQQGYGQQGQQNVPYQQNQYQQNPQQGYGQQQQQYMPPQNQQDQYQQNQQSQAPAAPNHFALAFKGCGGFPRYFKSNPTGAHDRMQQHPLWGWLIACTLQSVVGALFVMAFLNTYAGQIFRVVFVVTKDTAKYTSGAYTAAEGFLLFLIFLIVIFGVLVLRGVGLMLTARIGKSQMGFNSAMDIVGTAVLPQIPAFLVLFFLSFLLPHASTMTDTYAASQRPILVMMIVFAVFSVIVGESLLYLGQAKVANTEKSVFFMYVVLSTAFVLAGILVLYFGFSVLAPNPSSSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYK2</accession>
    <name>A0A2Z5QYK2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87390">
        <property type="protein sequence ID" value="BAV87390"/>
        <property type="gene ID" value="RA11412_1091"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1091"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="99" mass="10686" checksum="1960BB1996451093" modified="2018-10-10" version="1">MTHPKSVAASVIIPVYNGASYIMQQLDALAVQTGNPSFEVLVCDNGSTDDTRAVVESYNASYPLRVVDASQRAGASHARNMGRYRPWAMFLSSAMAMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYK5</accession>
    <name>A0A2Z5QYK5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase cytochrome b-556 subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Succinate dehydrogenase, cytochrome b556 subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Succinate dehydrogenase/fumarate reductase, cytochrome b subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sdhC</name>
        <name evidence="10" type="ORF">I6I94_03940</name>
        <name evidence="11" type="ORF">NCTC10207_00482</name>
        <name evidence="9" type="ORF">RA11412_1025</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87324">
        <property type="protein sequence ID" value="BAV87324"/>
        <property type="gene ID" value="RA11412_1025"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1025"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045281">
        <property type="term" value="C:succinate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039023">
        <property type="entry name" value="SdhC_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41910">
        <property type="entry name" value="PTHR41910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VEI22407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="152" mass="17099" checksum="0A72AB71C0D8F605" modified="2018-10-10" version="1">MPNMSKGTLYRGRYGMWSWVAHRVTGIAIFFFLLVHVLDTAVVRISPEAYNSVLSLYKNPIMGLGEMALVAAIVYHAFNGIRIILIDFWGPATNSKVEHIQKPNKDGIIETSEKATYNHIKILWVVLVLWVIFVAGFAVRHLPNVFAHIGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYS0</accession>
    <name>A0A2Z5QYS0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87384">
        <property type="protein sequence ID" value="BAV87384"/>
        <property type="gene ID" value="RA11412_1085"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1085"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="149" mass="16637" checksum="966E73555EC32357" modified="2018-10-10" version="1">MKKYVVALKGENRLEQFFNAPGSAGFYIFWGVDGRALPTPGQSPEFDAAYFEKRKGRLARPGEVGCALSHTYVWRDFLESGEEWALVAEDDALIHPSIDEIVSRVIEKSRSIGVVNFADGWSTQMGRMNPRTPYPGCRCCLRLFGAVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ12</accession>
    <name>A0A2Z5QZ12_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transport ATP-binding protein CydD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_1185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87484">
        <property type="protein sequence ID" value="BAV87484"/>
        <property type="gene ID" value="RA11412_1185"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1185"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="62"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="494" mass="54740" checksum="97A23801A74FF60A" modified="2018-10-10" version="1">MNQAFETPLYSHKEPFYVAAWGNSRYAVRLPLYGKVVMNNIVGAGRGTPMKVMRSLRPRALVMLTALTLILSASSVLESVIIKYLTDAVTSYDRVLFAWMLAAVPTYLVVDAFLHYVRQYRAALAGVQIQNNLRAELFRRIGLSPVARLTGRSSEYYFSQFTSQLESIKTNYIDVIFWGGYLTAQLIFAIVAAFILNPFMACAVLALSLPVGLMPVLTRKRIGAVTKAYASQTDVLNEISGDALRSALGWKILGAYSFVAKRFSEELSEWYVAARSYQRTQERVDAVNSMFTKLLYLGTWLAGGALVLSGLSSVGEVVAFVQLTGMICMPLFMSTGLLTQYYAGREIIRKINAEVPAVEDDRPGEPLTLDAFTYRDVKPLGEKSAGYGVSFIFETGKKYLVIGASGSGKSTLFKPLLEITPNIAELLRCTNRRKCAICVRLPNRICTLPWVCLRRTAICCTIACAKIFACTIRRCRMCRFSGLVSVQVWASGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ46</accession>
    <name>A0A2Z5QZ46_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ORF">RA11412_1419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87718">
        <property type="protein sequence ID" value="BAV87718"/>
        <property type="gene ID" value="RA11412_1419"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1419"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
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    </dbReference>
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        <property type="entry name" value="met_pdase_I"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="71"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
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        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="227"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
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        </ligand>
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    <feature type="binding site" evidence="2">
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            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
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        </ligand>
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    <feature type="binding site" evidence="2">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAV87718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="308" mass="33520" checksum="1FDD956E66EC459E" modified="2018-10-10" version="1">MRVGAAKILGMATSHNLPAEPGTAPVGCLAPGTITPMRKVPADIVRPEYVGKPTANEGNDSNMYTPEEVERVRAAGKVAAGAIVEAAKIAVPGTTTDQIDVLVHEYICDHGAYPSTVDYRGYPKSVCTSLNEVICHGIPDSTVLEDGDILNLDVTAYLDGMHGDTNKTLLVGNVDEESRLLVERTEEALNRAMKAVKPGRQINVIGRVIEKYAARFGYGVVRDYTGHGVGREFHSGLIIPHYDAAPAYDTEIKEGMIFTIEPMLTLGTIEWDLWDDNWTVVTRDRKRTAQFEHTMVVTSDGVDVLTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZB0</accession>
    <name>A0A2Z5QZB0_9MICC</name>
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        <submittedName>
            <fullName evidence="2">Nicotinamidase</fullName>
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    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="BAV87802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="118" mass="13085" checksum="52FB62CB0FE9693C" modified="2018-10-10" version="1">MAKALIIVDVQNDFCAGGALATDRGAKVASLISEYVEDNHHRYEAVVATQDWHIDPGAHFSDTPDFVDSWPVHCVANTEGAEIHPNLDTDYIEAYFRKGRYEAAYSGFEGLQAPRNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZB4</accession>
    <name>A0A2Z5QZB4_9MICC</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87564">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000250241">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="40" mass="4611" checksum="E4DABECFA298FBFB" modified="2018-10-10" version="1">MSCCKNYRVCAVRTVTSRFTVRTVSCVRFFAQFLWGGCIL</sequence>
</entry>
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    <accession>A0A2Z5QZG6</accession>
    <name>A0A2Z5QZG6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-Acetyl-D-glucosamine ABC transport system</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87885">
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    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1586"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="BAV87885.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="55" mass="5935" checksum="B4EEDEA759D1A1A8" modified="2018-10-10" version="1">MRGAHPHVCGEHIPIDSRSRVVLGSSPRMRGTHANEQPLIICSGLIPTYAGNTSR</sequence>
</entry>
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    <accession>A0A2Z5QZM3</accession>
    <name>A0A2Z5QZM3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87741">
        <property type="protein sequence ID" value="BAV87741"/>
        <property type="gene ID" value="RA11412_1442"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1442"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="343" mass="38558" checksum="55568CCEF2862327" modified="2018-10-10" version="1">MILGLALAELAEVKDNDGALWQELIATITGGTMTITRHARLENRRVSLLLIFEMMRFIDEMRSGSAAAPFMRPIPAQSRPWTRIHYPQAHLDIWWDSTRDEQELPIWEAPMMTEEQGVGAMQSAALGGPCTRIDGSCDTHEREEWTHTQHVPEWFAWLMQHNPDTYAAHSHIRLMRALTQNRVPEVQRTMWLLEASRQVPTAPVYSALALACSAKSVENRAAAAEAIAGLCASNLFDPAGFAHQVRLLLAEKLLTAGRLAKTLEDAAHMSALSGYRVLHVLAELLNEIKPAHQLLDLLGKLCVHYGWRCRFLSILPPHRKHVVLQHPPCVLLLPLSRMLRIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZW0</accession>
    <name>A0A2Z5QZW0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_01185</name>
        <name evidence="2" type="ORF">RA11412_1713</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887308.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88012">
        <property type="protein sequence ID" value="BAV88012"/>
        <property type="gene ID" value="RA11412_1713"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1713"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="141" mass="16297" checksum="D49E4192292CE287" modified="2018-10-10" version="1">MDSLLAPIMITLLCVIVFMIIRNRKVPAPTMPGEPGASYDPTTHYYDSKRDDFLNWLHARTSSPEIPVQVKLRDWVDQGFYAEDSGNYWGIAQQFTYYLLEGGYVRAYDTEGKELTAQRVLIDRPDTLQLTPSEYQRRTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R000</accession>
    <name>A0A2Z5R000_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88038">
        <property type="protein sequence ID" value="BAV88038"/>
        <property type="gene ID" value="RA11412_1739"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1739"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4397" checksum="5F0EC6963A0CDA56" modified="2018-10-10" version="1">MPLPQVSGVSMRDICSLSRATGPRLFLISTVHSASQYSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R002</accession>
    <name>A0A2Z5R002_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_02085</name>
        <name evidence="3" type="ORF">NCTC10207_00874</name>
        <name evidence="1" type="ORF">RA11412_1495</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888887.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87794">
        <property type="protein sequence ID" value="BAV87794"/>
        <property type="gene ID" value="RA11412_1495"/>
    </dbReference>
    <dbReference type="GeneID" id="32323105"/>
    <dbReference type="KEGG" id="raj:RA11412_1495"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI22788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="223" mass="25176" checksum="174A49488ADC86F2" modified="2018-10-10" version="1">MTTDIITTEFRDSWYAPRIDPPIPAHWPVTGEERGTLEDALWRLLSTGESDTARYEYYFWETPSLRDAYGSADWDGEVRAYIRQLIDSRRAYIAALGGVPGTPLNLSLAELERQGVKMNPDFGCCGIPHEAPQDGHTWYGYVSLGPEEAEELIKNGETRLSCGAFVTGEELEEMSDAEYNRINSAVIRQHILPVFERHGVEIDWDGTYIELPVLKNAEFFAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R009</accession>
    <name>A0A2Z5R009_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_1749</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88048">
        <property type="protein sequence ID" value="BAV88048"/>
        <property type="gene ID" value="RA11412_1749"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1749"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016744">
        <property type="term" value="F:transketolase or transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="9">
        <location>
            <begin position="253"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="608" mass="65692" checksum="80CB8F7E6ED12996" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R011</accession>
    <name>A0A2Z5R011_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent Clp protease adaptor protein ClpS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87804">
        <property type="protein sequence ID" value="BAV87804"/>
        <property type="gene ID" value="RA11412_1505"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1505"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="71" mass="8249" checksum="804F1EA1A3B0C69E" modified="2018-10-10" version="1">MWNDPVNLMTYVSYVFRSHFGFSRARAEELMLQVHHNGKAIVFTGSREEAEKHTHAMHGWGLQATFEKVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R028</accession>
    <name>A0A2Z5R028_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_1816</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88115">
        <property type="protein sequence ID" value="BAV88115"/>
        <property type="gene ID" value="RA11412_1816"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1816"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="263" mass="28243" checksum="88BEC75F1A1EAFD1" modified="2018-10-10" version="1">MNEETEGEHTTSGQAAVGTILTVVLLYLLISVGTLAFAGTSSEGLGLGNPDNQENIFAALSGPVLGALGIMMSFAVLISALASLQSTAVSPARTLLAMGYYKALGPKFANISPKFQSPSYATLASCLIATLFYVLMRFISTSVLWDTISALSLMVCLYYGITAFACVWYFRKVSFSSGVKEFLNKFLFPMLGGIMLLVFFARTSYDSMDPGYGSGSEIGGVGLVFCLSVAIFILGLCVMTYQRCVRPAFFKGKIPMEVEHMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R085</accession>
    <name>A0A2Z5R085_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87951">
        <property type="protein sequence ID" value="BAV87951"/>
        <property type="gene ID" value="RA11412_1652"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1652"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="153"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="338" mass="36741" checksum="C4015E36BC20D502" modified="2018-10-10" version="1">MNHGGGWSNDGRTLPGLLDIEFNPYSQYGNTCYNLSPAQLTNWIRDFNETYRSLTGRYPMVYTANSWWSQCVGTGEFGKTLLHLANYNYVPGPTPNGWKSYDIWQFSADGPFVGDSNFFPGSFNDLKALASNPQATNRSWHPATPAPAPKPAVKTRFSDVPTHAAFYTEIEWLASRNITTGYGDGTFRPDQSVERGAMAAYFYRMAGSPAVNLPKTSPSRMCPPTIPSIRKSCGCTSAVSPPVTVMVLSARTMPSAVKQLQHSCTVTAAAPPSRQFTVPGLRMFAPITPSTAKSSGLSPGRSPQVTVMALSARTILLAAELWQHSCTACANHLLGMHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0B3</accession>
    <name>A0A2Z5R0B3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87981">
        <property type="protein sequence ID" value="BAV87981"/>
        <property type="gene ID" value="RA11412_1682"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1682"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021904">
        <property type="entry name" value="DUF3516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12029">
        <property type="entry name" value="DUF3516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="56"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="232"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="751" mass="83239" checksum="BE40F2B6F999589E" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0F9</accession>
    <name>A0A2Z5R0F9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,4-diketo-3-deoxy-L-fuconate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88255">
        <property type="protein sequence ID" value="BAV88255"/>
        <property type="gene ID" value="RA11412_1956"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1956"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="144" mass="16371" checksum="01D72E4C9C3B0F9E" modified="2018-10-10" version="1">MRWAQIKDQKGTRAVCLHEQTVYEFPAKLGPLLQFYGRYRLNFGDPKNALAIMRENGATTLGHGMQLWESLNFVQPIDRPGKVICAGLNYRDHAAEMGFELPEYPAIFAKYANALIGPRDEIRMPAQSTKSTGKLSLGWWWVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0J4</accession>
    <name>A0A2Z5R0J4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_00130</name>
        <name evidence="3" type="ORF">RA11412_1996</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88295">
        <property type="protein sequence ID" value="BAV88295"/>
        <property type="gene ID" value="RA11412_1996"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1996"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="512" mass="53552" checksum="94E1388F8777D3C1" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0K0</accession>
    <name>A0A2Z5R0K0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88305">
        <property type="protein sequence ID" value="BAV88305"/>
        <property type="gene ID" value="RA11412_2006"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2006"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="79" mass="8593" checksum="94CE9C5369045B7A" modified="2018-10-10" version="1">MKVLGTTMMLASAVVFLTALFLLTAGHFSLLWVILLIIAPFVFMVGIPFATGSGPEYLPTDPRLAQQEREKRDAELGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0K7</accession>
    <name>A0A2Z5R0K7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Excinuclease ABC subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88268">
        <property type="protein sequence ID" value="BAV88268"/>
        <property type="gene ID" value="RA11412_1969"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1969"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrA_inter" evidence="2">
        <location>
            <begin position="147"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="314" mass="34752" checksum="7ADFA62F0AE90079" modified="2018-10-10" version="1">MSPRPGTSVPAAPRANDLNSIRVQGARENNLKNVDLTIPRDAMVVFTGLSGSGKSSLAFDTIFAEGQRRYVESLSSYARMFLGQVDKPDVDFIEGLSPAVSIDQKSTSKNPRSTVGTITEIYDYMRLLWARVGHAHCPECGEEITKQTPQQIVDTLMGYPERTRVQVLAPVVSARKGEFVDLFKDLLTQGYSRARVDGQTMQLSDPPKLAKQYKHTIEVVVDRIVIKDGINQRLTDSVETALRLADGRLLIDFVDEAEDSPERTRSFSENLACPNNHPCKSTQLSRAPSRLTPRSVPAKRATVSAPVSKWMKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R101</accession>
    <name>A0A2Z5R101_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-inositol 3-phosphate glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_00675</name>
        <name evidence="6" type="ORF">RA11412_1862</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88161">
        <property type="protein sequence ID" value="BAV88161"/>
        <property type="gene ID" value="RA11412_1862"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1862"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="78"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="193"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="388" mass="42846" checksum="49855106E92F41F2" modified="2018-10-10" version="1">MKLMVDARYTRIGFHDGISRYTASLLGALKGLMDSGAPEVADVQLVMVISDERQLQMLPDLPHVKICSPTGPLEPTAALQLNKYKPDVVFSPMQTIGSVGRKFKLVLTLHDLIYYDHPTPPGFLPAPVRAGWRLFHKSYTPQRMLLNRADAVVTVSESTARLIREHRLTEKPLHVVPNAPQPGSVVSEDEALHRAKSRAEGASRHLVYMGSFMPYKNVETLLYAMRELPGYTLHLLSKMPDARRAELEEQGLLSPLAAGSNVVVHNGVSDEEYAELLESAHALVTASRAEGYGLPVVEAQAAGCPAVISDIDIFREIAPHSVFASVTEDPQADAPAWVEAIRSLENDTVRDRVILEGLQDASHYSWRDSALKLIRIVRGINIIKRDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R121</accession>
    <name>A0A2Z5R121_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="8" type="ORF">RA11412_2044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887997.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88343">
        <property type="protein sequence ID" value="BAV88343"/>
        <property type="gene ID" value="RA11412_2044"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2044"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="212" mass="22848" checksum="64B7CBB8D7DFE64F" modified="2018-10-10" version="1">MSGYMPLPTGSGSAAARMASTAVGSQEDYVYNHLLKERIIWLGSEVRDSNANLICSQMLLLSAEDPKADIYLYINSPGGSVTAGMAIYDTMQLIPNDVVTVVTGMAASMGQFLLTAGTIGKRYATPNARILMHQPLGGIGGTASDIRTQAELILDMKKRLAEITAERTGKTLETILKDNDRDNWFTAQEGLDYGFFDHIATTAGGQFAQESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R132</accession>
    <name>A0A2Z5R132_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LSU ribosomal protein L32p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88382">
        <property type="protein sequence ID" value="BAV88382"/>
        <property type="gene ID" value="RA11412_2083"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2083"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="4799" checksum="DBBF33F77261187B" modified="2018-10-10" version="1">MPPLVKTIENGRVTYSLPHRAKVVTDAAGNALFLEYKGRKVADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R136</accession>
    <name>A0A2Z5R136_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP/GTP-binding integral membrane protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Cell division protein ZapE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">zapE</name>
        <name evidence="4" type="ORF">I6I94_10785</name>
        <name evidence="3" type="ORF">RA11412_2158</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88457">
        <property type="protein sequence ID" value="BAV88457"/>
        <property type="gene ID" value="RA11412_2158"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2158"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="PTHR12169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="350" mass="38466" checksum="40445CD827544AFE" modified="2018-10-10" version="1">MPVTYEHLTDRTPHVSADELLAGFRPSERFGEVSFDSYIPDPNQPSQAEAVQKLKTFGDKINKGGGTGGFFGKLFGGKKKDTTKAGLYLDGGFGVGKTHLLASLWHYVDGPKAFGTFVEYTNLVGALTFRKTVEALSSYKLVCIDEFELDDPGDTVLMSRLMRELADAGVKLVATSNTLPGALGEGRFAAEDFKREIQVLSQQFEVHRVDGEDFRHRGLPAAPEPVTDAELDAKTEEVFGSKSVAVDNFTDLVAHLAKVHPSRYRQLIDGLEGIAWRNVQPITEQAVALRFVVLADRLYDKDLPIVSSGVPFDQVFTPEMLAGGYQKKYFRAVSRLTALAREGLLGETEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R147</accession>
    <name>A0A2Z5R147_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formate--tetrahydrofolate ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88270">
        <property type="protein sequence ID" value="BAV88270"/>
        <property type="gene ID" value="RA11412_1971"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1971"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="189" mass="19912" checksum="D32303E77D5B611D" modified="2018-10-10" version="1">MRNFGVQPVVAINAFPTDFDSEHEAIRRIAEEAGARVAIHRGVAEGGKGTVDLANVVAEACDDVSELKFTYDLEDSLETKLEKVATKVYGADGISIAPAAAKQLKRFADLGYGNLPVVIAKTHLSISSDASLKGAPTGWTLPVREVRLAAGAGYVYAICGTMRTMPGLSKSPAAERIGFDENGTMVGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R163</accession>
    <name>A0A2Z5R163_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88487">
        <property type="protein sequence ID" value="BAV88487"/>
        <property type="gene ID" value="RA11412_2188"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2188"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="377" mass="40691" checksum="7A98957821D74429" modified="2018-10-10" version="1">MRALNPVLLHARREGNKQLVGALAGFTRTLEALLTDGLNNTGHMLSLCPNTRPVIAQPALKQMYELYPQALERLVAATNLTRVLSKFHREYEASLEVVAYVKAALAIVPHLHDYVETTGNRFYAKYARHREEALNSVLEARSETGHDALFLANLHEWVNTTGITAPDNLSRRTENNIRRLSAQIAATRTRRALAESVVYAAGGLTELQNIDTARLAHLFSVVNDEPADADEPTGVPPRVLAEAKALSEKIRSACLKQFPELAEGNRATAEPSMSAFYAAALAGSAYAFDGVHAVREQLLENMRADRAESSELPAVCWYWPHNTRAGDAYGADIDWDVSGDFGGWENCDMGGSDFSGCDSSGGGDFGGSDGGGGGGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R194</accession>
    <name>A0A2Z5R194_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="2">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88517">
        <property type="protein sequence ID" value="BAV88517"/>
        <property type="gene ID" value="RA11412_2218"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2218"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="4">
        <location>
            <begin position="36"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="262" mass="28361" checksum="526EB8A54290974F" modified="2018-10-10" version="1">MKGKDLAASNYTARHLSVLEGLEAVRKRPGMYIGSTDSRGLMHCLWEIIDNSVDEALAGYGQSIQIILHRDGSVEVQDDGRGIPTDIEPRTGLSGLEVVFTKLHAGGKFGGGSYTASGGLHGVGASVVNALSSRLDVQVDRGSKTYQMSFRHGMPGRFDSGRTPKPEDTFTPAAEGAEALQIVGRAKRGVTGTRVRYWADPQIFTPDARFSYEDLVSRARQTSFLIPGLRIAIRDERRVPGTPGEFGPTKKFFNMMAALVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R198</accession>
    <name>A0A2Z5R198_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Uricase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_00175</name>
        <name evidence="4" type="ORF">RA11412_1987</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88286">
        <property type="protein sequence ID" value="BAV88286"/>
        <property type="gene ID" value="RA11412_1987"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1987"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033776863" evidence="2">
        <location>
            <begin position="47"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="94"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="284" mass="30622" checksum="77B35F8A5EE5D9E2" modified="2018-10-10" version="1">MCNTSSPRTITESAQPGVPRRAFVLGTLVPLLAGCSFGAQNTVDNAANSQGQTPPVPVNGKTSSGSPTASVSANPGPTPYPWDGPQVGLPGDGKYIAWTVDDGKSPEVVRAYADFAAKTGTRLTFFINGSYDSFEQNLDVLAPLVTSGQIQIGNHTWSHAALTDLDDAGIIEELEKNDREIERLFGMSSKPYFRPPYGYYDRRVLDAAARAGFDRPTLWYGSLADSSPITSEEIYKYASTYANPQTILIGHLNYTGVIAVLDKIKALLDERGLVTVTLRDYYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1A1</accession>
    <name>A0A2Z5R1A1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome small subunit-dependent GTPase A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ribosome small subunit-stimulated GTPase EngC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rsgA</name>
        <name evidence="4" type="ORF">I6I94_10405</name>
        <name evidence="3" type="ORF">RA11412_2266</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88565">
        <property type="protein sequence ID" value="BAV88565"/>
        <property type="gene ID" value="RA11412_2266"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2266"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENGC_GTPASE" evidence="2">
        <location>
            <begin position="129"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="375" mass="39641" checksum="D8595C6CBC851096" modified="2018-10-10" version="1">MGSSRLNSRDVLDWDESDVRVRPNKRGSRPRTKDRPAHKSAIRGRVITVDRGRWSVVVAEGTVNERTLVATRARELRRTAIVTGDFVDVVGDTSGKKDTLARIVRLGERSCVLRRSADDTDPTERVVVANANQLVIVVAAANPQPRTGFIDRAVVAAYDAGIEPILCVTKTDIRHPQELLDYYQRSGLRIVLSAASDGRAPSEEGAEGLTTGPVRELLGDLLGNVSVLLGHSGVGKSTLVNALTGAERATGHVNSVTGRGRHTSSSALALQPASDAGVEVPPGTWIIDTPGIRSFGLAHVSMQKVVEAFPDLAPGAVECPRGCAHTDDSSGCGITAYVARGEAGPSGADRLASMRKLLAAPNQAGNDEKELGSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1A5</accession>
    <name>A0A2Z5R1A5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88433">
        <property type="protein sequence ID" value="BAV88433"/>
        <property type="gene ID" value="RA11412_2134"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2134"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4493" checksum="14BFFA615C357DD7" modified="2018-10-10" version="1">MVYVIGNCDWQCPLRSLAANSLGQLVSAINDAPPLSLNYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1B7</accession>
    <name>A0A2Z5R1B7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88284">
        <property type="protein sequence ID" value="BAV88284"/>
        <property type="gene ID" value="RA11412_1985"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1985"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="151" mass="15904" checksum="D299818190AA33DD" modified="2018-10-10" version="1">MLLAGCSAEVAPGLTFTPAQDYGNRGDITVSAEVLSGNEHNGFHAKAGKVRFFQDGIEVNSAEQKLTEKTGYYRVGASNSHELAGKTISVAVYADDPQDTVKCAIKVTGEDHPVHHSEQAEGKGSAYCQVKLSSGPYQLPAGASGESKHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1F5</accession>
    <name>A0A2Z5R1F5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88324">
        <property type="protein sequence ID" value="BAV88324"/>
        <property type="gene ID" value="RA11412_2025"/>
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    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="4912" checksum="CE539FE481257B0E" modified="2018-10-10" version="1">MAVCPHYLLEGRHIMQAHLGIVTNDECSADPRDGWGILKFYGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1J2</accession>
    <name>A0A2Z5R1J2_9MICC</name>
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        <submittedName>
            <fullName evidence="2">Cytosol aminopeptidase PepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF00883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="BAV88532.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="69" mass="7520" checksum="EB50A54FFF962CC3" modified="2018-10-10" version="1">MGSRYGSMMIAGLFLQEFVGEVEGQRIPWAHLDIAGPAFNEESPFGYTPKEGTGFGTATLVNFIESYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1K2</accession>
    <name>A0A2Z5R1K2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxoglutarate dehydrogenase (succinyl-transferring)</fullName>
            <ecNumber evidence="3">1.2.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_2259</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
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    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88558">
        <property type="protein sequence ID" value="BAV88558"/>
        <property type="gene ID" value="RA11412_2259"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2259"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0030976">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
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        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="85"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="E1_dh" evidence="8">
        <location>
            <begin position="476"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
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            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAV88558.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="684" mass="73964" checksum="5B6FE1A5E023B48A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Q7</accession>
    <name>A0A2Z5R1Q7_9MICC</name>
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            <fullName evidence="8">Probable low-affinity inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86789">
        <property type="protein sequence ID" value="BAV86789"/>
        <property type="gene ID" value="RA11412_0490"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="137" mass="14322" checksum="0131C2FD78A62E18" modified="2018-10-10" version="1">MALSTTHVATGSILGTGLGRKGAEVRWGVAGRMVVAWVITLPAAAAIGATTWMIGAGLNSLTNTQFVGELVVFAILVVFCLWMWRHSQKDAIDASNVTNSWDGEAVAAAEESLTADEAPMDDSAKNHQEALPQKAGA</sequence>
</entry>
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    <accession>A0A2Z5R1R8</accession>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="57" mass="6040" checksum="894E71AB90C43604" modified="2018-10-10" version="1">MFSSENTKGKPYSLYTAEALSVGDARNGQAYLADRSIDLKMSVPKEMGGAGDGINPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R207</accession>
    <name>A0A2Z5R207_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear transport factor 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_10625</name>
        <name evidence="1" type="ORF">RA11412_2212</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88511">
        <property type="protein sequence ID" value="BAV88511"/>
        <property type="gene ID" value="RA11412_2212"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2212"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="125" mass="14196" checksum="CBB24745EB17E130" modified="2018-10-10" version="1">MIDETMKALTEELIARGTSYDIDFLRRVYADDLKFVRILPDNTVQILSKQDNIDFFQALKDNGAAPLNTAHTILFADSDGETGTIVLKRRMSQGAQEQDFLFTITWKKRSENWQIVQEIVAVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R256</accession>
    <name>A0A2Z5R256_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA pseudouridine synthase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88835">
        <property type="protein sequence ID" value="BAV88835"/>
        <property type="gene ID" value="RA11412_2536"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2536"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="167" mass="18712" checksum="B54E753FF56FDE5F" modified="2018-10-10" version="1">MEEHWLTLTDSTNHKENTMLALWEAGVQEDSVQDFEMQEYDPALIAMRCGDDFADAAISVRAPGLRRVRIDLAYDGSFFSGWARQPSRVTVQGVLESALELILRSPHRVTVAGRTDAGVHAEAQTVHLDITEETWQKLTGREGNQDPACTLHRRLTGPCAARWGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2A3</accession>
    <name>A0A2Z5R2A3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_2586</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88885">
        <property type="protein sequence ID" value="BAV88885"/>
        <property type="gene ID" value="RA11412_2586"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2586"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="8">
        <location>
            <begin position="6"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="7">
        <location>
            <begin position="139"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="9">
        <location>
            <begin position="400"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="492" mass="54950" checksum="B7002D9DEF77CFB9" modified="2018-10-10" version="1">MKVPNLLAIQTDSFDRLVGNAGWLARLEAAEAAGDTSVPRKSGLAEIFEEISPIKDFQETMQLSFSDPEFADPKYTVEECKDRDATYAAPLYVKAEFINHATGEVKQQTLFMGDFPLMTESGTFVINGTERVVVSQLVRSPGAYFEKAPDRTSDKDIYSARVIPSRGAWFELEIDKRDQVGVRLDRKRKQSVTVLLKALGWSESKILSEFGQYDSIRATLEKDSVSTRDEALLDIYRKLRPGEPPTVEAAQALLDNMYFTPRRYDLAKVGRYKVNRKLGVEVPLDSDEASVLSQDDIAQMIHYLCALHAGEPTIKGSRGGQEIDLKVDVDDIDHFGNRRIRTVGELIENQIRTGLSRMERVVRERMTTQDVDAITPQSLVNIRPVVAAIKEFFGTSQLSQFMDQNNPLAGLTHKRRLSALGPGGLSRDRAGMEVRDVHPSHYGRMCPIETPEGPNIGLIGSLATYGRINSYGFIETPTAWLKTARSLTRCVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2I4</accession>
    <name>A0A2Z5R2I4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-succinyl-L,L-diaminopimelate desuccinylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="4">3.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_09920</name>
        <name evidence="3" type="ORF">RA11412_2382</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88681">
        <property type="protein sequence ID" value="BAV88681"/>
        <property type="gene ID" value="RA11412_2382"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2382"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010174">
        <property type="entry name" value="Succinyl-DAP_deSuclase_DapE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01900">
        <property type="entry name" value="dapE-gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="189"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="376" mass="40819" checksum="85796BF87098A66C" modified="2018-10-10" version="1">MSHPTAAIDTNVSMPELTRVLLDIYSVSGEEKTLADAIYRALETHPHLHLVRDGDAIIARTDFGPQNGQQRTRILLAGHLDTVPLPTVAGSLGTVPSRVVEEDGDWVLYGRGATDMKGGVAVQLKLAAELTAHETDYDLTYIFYDNEEVASEKSGLARLIRNHGELITDADFGVLLEPTDGTIEGGCNGTMRFYLRTTGLAAHSGRAWKGENAIHHLADALTTLAHYTPQTYRVQGLDYREGLNAVQVSGGVAGNVIPDAAALHVNYRFAPNKTLDEAVAHVQELFQGYELDFVDLSPAARPGLDTPLAASLIAAVGQEPKPKYGWTDVARLSEIGIPAVNFGPGDALLAHTDNEHVRFSELNRCYSELRNWLMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2I5</accession>
    <name>A0A2Z5R2I5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Glycine betaine ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_04760</name>
        <name evidence="7" type="ORF">RA11412_0810</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87109">
        <property type="protein sequence ID" value="BAV87109"/>
        <property type="gene ID" value="RA11412_0810"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0810"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="27"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="248" mass="25817" checksum="15324240424AE90F" modified="2018-10-10" version="1">MNVIERTFAFLGDGANWQGAQGILARTVEHLGITVFAVAIALVIAVPLGLWAGHTRRGGHALLGFTAALRALPALGLLTLLALWFGVNAIPPLVVLVIIAVAPLLAHTLEAVTGIDPDVVDAARAQGMTEGQILRRVEIPLGLPVFMGGLRSAVLQVIATATIAAYINGNNLGRYLFDGLAVRDYPRMLVATLLVAILAFVVDAIMALAQRAVTPVPLRGGGASKPHGQPKHESALDAANSHTEGAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2I8</accession>
    <name>A0A2Z5R2I8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sucrose-6-phosphate hydrolase</fullName>
            <ecNumber evidence="4">3.2.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Invertase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_2614</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Enables the bacterium to metabolize sucrose as a sole carbon source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.</text>
            <dbReference type="EC" id="3.2.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan biosynthesis; sucrose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88913">
        <property type="protein sequence ID" value="BAV88913"/>
        <property type="gene ID" value="RA11412_2614"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2614"/>
    <dbReference type="UniPathway" id="UPA00238"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005985">
        <property type="term" value="P:sucrose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006232">
        <property type="entry name" value="Suc6P_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01322">
        <property type="entry name" value="scrB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="6">
        <location>
            <begin position="90"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="565" mass="63401" checksum="C9714EA10B415910" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2J1</accession>
    <name>A0A2Z5R2J1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09640</name>
        <name evidence="2" type="ORF">RA11412_2445</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88744">
        <property type="protein sequence ID" value="BAV88744"/>
        <property type="gene ID" value="RA11412_2445"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2445"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="71" mass="7699" checksum="DE79EFB4161F51C0" modified="2018-10-10" version="1">MSREPNPARGVGQDVRDARRALGWSQAELANRAHVSRPTIARVETGVNISTGTLEKVAKALGKRLHISDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2J2</accession>
    <name>A0A2Z5R2J2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamate ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Glutamate binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Sulfate starvation-induced protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fliY</name>
        <name evidence="5" type="ORF">I6I94_09900</name>
        <name evidence="6" type="ORF">NCTC10207_01620</name>
        <name evidence="4" type="ORF">RA11412_2387</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887469.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88686">
        <property type="protein sequence ID" value="BAV88686"/>
        <property type="gene ID" value="RA11412_2387"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2387"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340105" evidence="2">
        <location>
            <begin position="35"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="40"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VEI23575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="282" mass="29901" checksum="7AE2406842741651" modified="2018-10-10" version="1">MKKSFINRAAAKFFAAGTAAALALGFALTGCSSAADAKPKIRIGIKYDQPGLGYQDGREFTGFDVDIAKYIAGKLGYSEEQIEFVESPSANRENMLSNGQVDMIVATYSISDSRKKSIDFAGPYYVAGQDLLVRSDETNITGPDSLNGKNLCSVTGSTSAKKIQDKFAKNVNLVNQNSYSDCVVALNGGVVDAVTTDDIILAGLAATKANKGKLKLVGQTFTTEKYGVGLPKGTDKCEAVNKAINEMVADGTWQRLVEKNTEGTGYTYNSNNNPPHPGASCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2J6</accession>
    <name>A0A2Z5R2J6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87119">
        <property type="protein sequence ID" value="BAV87119"/>
        <property type="gene ID" value="RA11412_0820"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0820"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="223" mass="25902" checksum="645C589E4BC936DA" modified="2018-10-10" version="1">MQKSEPSRTETSLRERRRERTWVNIHETALRLARQHGMRGSTVEDIAAEAGISPRTFFNYFGTKEDAVLGLRAPAITDELLASDRAHENDNLIVRITHLLLYIVRHSFNFANHAKFRERIDEFPEFRHRLKVHHINCEQVLIDYLNTVDWDAFNAAGRRGPLITRPENMPLTETAEERTRATVQLASAVLRQLHFAKDIADDNEVERRIHNTVKTFQALLKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2K2</accession>
    <name>A0A2Z5R2K2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgi</name>
        <name evidence="9" type="ORF">RA11412_2397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88696">
        <property type="protein sequence ID" value="BAV88696"/>
        <property type="gene ID" value="RA11412_2397"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2397"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="430" mass="47262" checksum="40D0A760B290B5D5" modified="2018-10-10" version="1">MYAFADRVRSGEWTGVSGKRIETVVNIGIGGSDLGPVMVYEALKPYADAGISARFISNIDPTDVAEKVSDLDPETTLFIVASKTFGTLETLTNARVARDWLLTALGEANALQGKTAEEAVAQHFIAVSTALDKVAAFGIDPENAFGFWDWVGGRYSVDSAIGTSLAIVFGPKVFEEFLAGFHAMDEHFRTAPFEKNVPVLMGLLNVWNVNFLGAETHAVLPYDQYLHRFPAYLQQLTMESNGKSVRADGSFVDYSTGEVFWGEPGTNGQHAFYQLIHQGTRLIPADFLAFANPAHPTKDGEQDVHELFLANFFAQTQALAFGKTEDEVRAEGTAEHVVNARIFSGNRPSTSIMASRLTPRVLGELIALYEHITFVQGIVWGIDSFDQWGVELGKKLALDLVPAIEGDREVLERQDSSTASLIDYYLKHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2N3</accession>
    <name>A0A2Z5R2N3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88988">
        <property type="protein sequence ID" value="BAV88988"/>
        <property type="gene ID" value="RA11412_2689"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2689"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="84" mass="9173" checksum="B399EE541BC605D7" modified="2018-10-10" version="1">MELAAGQSWHEHHSVHPVVVQALKGKIDFRVKGQSVILVPGKPIHVTADLLHSLTALEDSTLMVTMLTGESHPDAKPTVEFDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Q1</accession>
    <name>A0A2Z5R2Q1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89008">
        <property type="protein sequence ID" value="BAV89008"/>
        <property type="gene ID" value="RA11412_2709"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2709"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="329" mass="35685" checksum="AD46AE130CD968F9" modified="2018-10-10" version="1">MDFTGSHWGRTVSFAGCTFTETADFSSSFYEGEATFEGATYRSGAGFVQCVYHQDVRHTGSVYRTGAEFGASTYRGAADFSRALFYGPTDFGVSVFCGGPQHPVNFSCCVFAEAADFSKSCFCAYTDFSTVQWMDTAFFEYCIFYDGTAMRGSSFTGEAVFAESVFLADANFSNITCEADADFDSCSFYSNYRSDESEYEGAVGFTNALFLGDVDFAGARFTGDAPSFEEAVFAPGVLTRLPHKNQPSDGHQHPDTAPAIELTQAPAGARLLPADGTAQAHTLLSTIPHQIATVQGREGENMNFLTAGNELRAATESLWEWSQQVRDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2S4</accession>
    <name>A0A2Z5R2S4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 13" type="primary">rpsE</name>
        <name evidence="13" type="ORF">I6I94_09185</name>
        <name evidence="14" type="ORF">NCTC10207_01764</name>
        <name evidence="12" type="ORF">RA11412_2551</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888721.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88850">
        <property type="protein sequence ID" value="BAV88850"/>
        <property type="gene ID" value="RA11412_2551"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2551"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="55"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV88850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT88686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VEI23841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="224" mass="24089" checksum="7F79A5624BEDAE12" modified="2018-10-10" version="1">MSEQNEKETQVSEATVAETAETSKQREDRRSNRGERRGRGDRKNNRAREEEKDKYIEHVVAINRVAKVVKGGRRFSFTALVVVGDGNGMVGVGYGKAKEVPSAISKGVEEAKKNFFRVPRIEDRTIPHRVQGEAAAGVVMLRPATAGTGVIAGGPVRAVLECAGIHDVLSKSLGSANQINIVHATVAALKQLEEPLAVAARRGLPADEVIPSYLRNTKSDKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2S5</accession>
    <name>A0A2Z5R2S5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89067">
        <property type="protein sequence ID" value="BAV89067"/>
        <property type="gene ID" value="RA11412_2768"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2768"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV89067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="265" mass="29691" checksum="3BA3B38B3B59D844" modified="2018-10-10" version="1">MKNKQPHSAHKDFTMDQTQSRRGRPPRITHDQIAQAVIDVGFPNLTFAAVREKLGVGESTLYRYAPDRDELVRMGLNYAFSQVEMPPLEGHWRDILHSQAVHLWRSFEKYPGSATEAARGVVPAVAMYFLEELCAALIRRGFTPENAVIACDTLFDMVIDNRRGVEHIDALIPDGGPGRENILEQVGQDQPAPHQQDQDQDTDPYREQAQQAILDVFTRDPYDWLICKITIILDGIAQSLAPQQPPDASALPDDSPAEHSDDTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2V7</accession>
    <name>A0A2Z5R2V7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">rpsL</name>
        <name evidence="10" type="ORF">I6I94_09060</name>
        <name evidence="11" type="ORF">NCTC10207_01789</name>
        <name evidence="9" type="ORF">RA11412_2581</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 5 7">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5 7">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005504939.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88880">
        <property type="protein sequence ID" value="BAV88880"/>
        <property type="gene ID" value="RA11412_2581"/>
    </dbReference>
    <dbReference type="GeneID" id="61436361"/>
    <dbReference type="KEGG" id="raj:RA11412_2581"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT88661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VEI23891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="124" mass="13581" checksum="1427CA06A149F1E5" modified="2018-10-10" version="1">MPTIQQLVRKGRTPKVVKTKAPALKGNPMKRGVCTRVYTTTPKKPNSALRKVARVKLNGGVEVTAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYKIVRGALDTQGVKGRGQARSRYGAKKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2X3</accession>
    <name>A0A2Z5R2X3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87239">
        <property type="protein sequence ID" value="BAV87239"/>
        <property type="gene ID" value="RA11412_0940"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0940"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="54" mass="6622" checksum="A4A7FA607EB72FA7" modified="2018-10-10" version="1">MEQKEYLEGKFQEIEKINNKLFEVKDLKEKEELSKKLQALNEELHKWREEVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R312</accession>
    <name>A0A2Z5R312_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87289">
        <property type="protein sequence ID" value="BAV87289"/>
        <property type="gene ID" value="RA11412_0990"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0990"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="450" mass="50330" checksum="B81E237D53EB9485" modified="2018-10-10" version="1">MDIQCVPAFILGIITIIAVLCLIFRWFGLKKVRSFYVWIGVLAVLGGAWAFLFPLAINADFGKDGDGAALRQMLIYTTGGVLGVITLGENHRKNSLEKAKNDQDHLRQVHAERRSRYTTAVEQLSSDKASIRLGGVYTLVGLVDEWLSDEKTTPSPEKRRKEGQVIINNLCAYIRSPFLLAERAEQLDRPYAKDLKKDFGSDTEKFDADKRGFSQDKATLEEERQVRQSIIKAIRERLQGFGAPGPWSNFDYDFSNTLFFYSTNFMFSHFDAFSYFHGVTFTQNADFSWAKFTGHADFSWAEFTGSTHFSSAIFTDSASFSGAEFTGSTHFSSAIFADSASFSWAEFTGDAHFSGAEFTSANFSGATFEEKPIFERALGDKTYKARFSCKANPEDYNFEVSPASPYKIETEEQEHNGAKFIIPKGTELLTPTNLPSRATTAATKIFLDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R326</accession>
    <name>A0A2Z5R326_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88871">
        <property type="protein sequence ID" value="BAV88871"/>
        <property type="gene ID" value="RA11412_2572"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2572"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="229" mass="25512" checksum="639C34CDAAB9DF9C" modified="2018-10-10" version="1">MARLRLASYSFTGTGLALLPLTGIATYHLGVWDNGRMIWLITSLVGTVAIVLACTMMRNRIMAYLLVSFFISDALAATRVAELPFVWYFVLLTVLATILGLILRLNAKLVPTGLREGLVESSRIFVPVTAAVVFFFVSNMSFLEVGVVFAIMSVYALVFFTLDNKLDYYIQLRIYPLLAVIYFCIELHNLPLLFAFLFLAVLLSNTLAALLCYPIIMQRKGYDQNGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R392</accession>
    <name>A0A2Z5R392_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-succinylbenzoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88991">
        <property type="protein sequence ID" value="BAV88991"/>
        <property type="gene ID" value="RA11412_2692"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2692"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="4533" checksum="CBD7032164909515" modified="2018-10-10" version="1">MPFSRAASTHHDGSNSPGITPYGFVSEGTPLPPLEKSLTPHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3N5</accession>
    <name>A0A2Z5R3N5_9MICC</name>
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        <submittedName>
            <fullName evidence="3">Cell division protein FtsL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87689">
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        <property type="gene ID" value="RA11412_1390"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1390"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="269" mass="28735" checksum="6428FAD6F2F49CA5" modified="2018-10-10" version="1">MRTSRGATLLDAPARFLAYTRGVAGVFEKPSTAQFEANTTSARPKPARGGTAGRAEVREASGAKKRAPLARSLRKPTRRGGIMSLLMWAVFLVIPLFLIFNLLMNILVAQRQYELVDMHAQELALTQQNEALHQELGYNEAPQDLAIRASLLNMFPSTTPATLDVQNGTIQGTPTPAASPTSANGTRGNLVPAPATRDNDPSGQKAADAQKQAQEKTAKQNREREEKEKQEKEKASAAASPSPSASPQGSQSPQQAQPSQAAPSASANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3P8</accession>
    <name>A0A2Z5R3P8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">atpE</name>
        <name evidence="16" type="ORF">I6I94_02185</name>
        <name evidence="17" type="ORF">NCTC10207_00854</name>
        <name evidence="15" type="ORF">RA11412_1470</name>
    </gene>
    <organism evidence="15 18">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="16 20" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 20">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
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        <property type="protein sequence ID" value="BAV87769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888883.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87769">
        <property type="protein sequence ID" value="BAV87769"/>
        <property type="gene ID" value="RA11412_1470"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1470"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV87769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QQT89460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VEI22768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="69" mass="7074" checksum="ACFFADF39BE42581" modified="2018-10-10" version="1">MEITGSITAVGYGLAAIGGGIGVGLIFAAYMTSVARQPESRKALQPMLFMGFALVEALAVLGLVLAFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3U3</accession>
    <name>A0A2Z5R3U3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_01230</name>
        <name evidence="2" type="ORF">RA11412_1700</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87999">
        <property type="protein sequence ID" value="BAV87999"/>
        <property type="gene ID" value="RA11412_1700"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1700"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="35"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="226" mass="25225" checksum="A3036FAF9F0056B4" modified="2018-10-10" version="1">MVFYKLSQKTVTGLLRSVFRARVTGLDRFPKTGPVIVASNHLSFLDSIIISAMMPRRVAFLAKAEYVNTPGIRGKAMKAFFETVDIIPVNRSDRSESLKALDIALEKLNEGKVFGIYPEGTRSRDGYLYRGKIGVAWLAHMTGAPVVPVGLIGTDRLQKPGSNMVYPHRFTIRVGEPMWFEKTGEQMTGKQRRQTTNQIMDEIAQLSGQARKDEYNISPSAERDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3W3</accession>
    <name>A0A2Z5R3W3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron-sulfur cluster assembly protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88059">
        <property type="protein sequence ID" value="BAV88059"/>
        <property type="gene ID" value="RA11412_1760"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1760"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="281" mass="31011" checksum="88D762A9D7BFF167" modified="2018-10-10" version="1">MQREDERIGLAGVPEDRVAANAWSHFKTATVVTIPAEAELNEQVEIAIVGTHRDPAAQHLVVEAKPFSKSVVVIRHTGSATLAQNIEFLVGDSAQLSVICVQQWDDDAVHASAQYAKLGRDSRFKHVCISLGGDLVRVTPSTKFTQPGAETEMYGLYFVDAGQHIESRLFVDHSVPNCKSRVTYKGALQGKGAHSVWVGDVLIGKDAEGTDTYELNRNLLLEVGPAQTRCRTLRSRPDVLRARATRRLPVSWMMSTCGTCRRAVFLRLRRAVWWCAASSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4A1</accession>
    <name>A0A2Z5R4A1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88419">
        <property type="protein sequence ID" value="BAV88419"/>
        <property type="gene ID" value="RA11412_2120"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2120"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="65" mass="7427" checksum="4D0B784EE08DAF46" modified="2018-10-10" version="1">MYEWPMEYFIKFGDFEVISGKVRETPASATNSVTRSGPLKARYEDHKWVIDFSEFTANTNTSSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4D0</accession>
    <name>A0A2Z5R4D0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88489">
        <property type="protein sequence ID" value="BAV88489"/>
        <property type="gene ID" value="RA11412_2190"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2190"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="40" mass="4834" checksum="2223029D1A2FD397" modified="2018-10-10" version="1">MFGLLFGFIRDEGVRWREKPARLKSYILATWILLRCWGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVC2</accession>
    <name>A0A2Z5QVC2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86331">
        <property type="protein sequence ID" value="BAV86331"/>
        <property type="gene ID" value="RA11412_0032"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0032"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_IV" evidence="1">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="68" mass="7787" checksum="171FDCB24C108CD6" modified="2018-10-10" version="1">MDRVRAHYAGAPVEVEDSDGTTFTNTEEGWWANLRPSNTEPFLRLNLEAPDTPTMERVRDEILALVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVF1</accession>
    <name>A0A2Z5QVF1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable ATP-dependent helicase lhr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86346">
        <property type="protein sequence ID" value="BAV86346"/>
        <property type="gene ID" value="RA11412_0047"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0047"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="1486" mass="160090" checksum="5D22D27C5BE641AF" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVG2</accession>
    <name>A0A2Z5QVG2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86372">
        <property type="protein sequence ID" value="BAV86372"/>
        <property type="gene ID" value="RA11412_0073"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0073"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="PTHR42110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="390"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="459" mass="47028" checksum="4D14D32A8C78B1D3" modified="2018-10-10" version="1">MRPEACKTLLIGCMNSAHIAEAATPVRDAELAVATRGGMIESRHRGTVVVLSPGGDVILALGDAHRPIFARSTLKPFQAIGALKAGAPLRGAQVAIACASHRGTFEQMRAVQEALAAAGLSADALQCPAVYPTDSGTRATMLQAGLAKTPLAFECSGKHAAFLWACAAKSERGELEPDAALWSIDTYLDPQHPLQRMIVEEVEAFTGEQVAHASVDGCGAPVFALSPVGLARAYATLGTAIRNMEADARASTVATAMVDYPELIQGPDSPDTVVSERLDAVVKSGAEGMLCVGLRSGASAVVKISDGSSRATHLVALRALQAAGFLTQTTVDSLLTAVLRPITGGVEDGQPRTVGELVPGTDLAAVLAGVAPAVAARHGSDGACLTVHEEKAHEETTQREKTPGEPDGADSTATGKEADGTQTSGAAGGSAGAAPGRGVNGRPVRHALKGRRNGKKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVH5</accession>
    <name>A0A2Z5QVH5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86397">
        <property type="protein sequence ID" value="BAV86397"/>
        <property type="gene ID" value="RA11412_0098"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0098"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="4761" checksum="3D244B815281D6C9" modified="2018-10-10" version="1">MYCTHCRMRPAMTVHTAGIRTESDRAAAGTAHCSPAHGKNFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVQ5</accession>
    <name>A0A2Z5QVQ5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86473">
        <property type="protein sequence ID" value="BAV86473"/>
        <property type="gene ID" value="RA11412_0174"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0174"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016315874" evidence="2">
        <location>
            <begin position="26"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="178" mass="19232" checksum="D879A25B9055CB4B" modified="2018-10-10" version="1">MQTFKLLARRTLPTSQATLPVLAFAASAALFLLIAGGIHAFYLWLGGDASTATSVEAGSGTKNTAHTLQPLYLMLAWVSGFLLLTPLFTLGASAARLSARRRDDRLATLRLLGASTRQLTLYTMLDSVIYAAVGFVLGFIVYLILVLPFGMLRFQNIPWAPKICCCRCLSCWPAGLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVW0</accession>
    <name>A0A2Z5QVW0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86521">
        <property type="protein sequence ID" value="BAV86521"/>
        <property type="gene ID" value="RA11412_0222"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0222"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="429" mass="45069" checksum="D5C3D8F10EF8B082" modified="2018-10-10" version="1">MHSTPAPPPRAILIRRTRHIMVFGLLLSTLGNNTVEYGFNALTAAGVVSVGALLTLSALRRLSAFAFPAIAKLMGKHSPDKVLIACDSTETVLSALALTITLLAPHQAIWTVYAYTLIDLLILAFTDIAEEFYGAHFAQINEDTAMAFNASLSTIQAIVNFVVAGLAGSLLAGVSIPTLLAVNTALSLAAALFRARARHTYPVPPPTTINASQFAATGHKEPLRQFLHDLFTSGPASPLVSLAIAFAGTMSGELFILWAANHGPAVPLPGTDNTAYTGMGLVLTVFGLGAAFGPQAGKWLRQAGETAPILRTAALFSAALTGALATGILTDTILPPLIPVFVFLNAAASRARAVVLETHRQAYFRGAQFARIMSWSFTFSAAGTLLGLLVGYLLGQAYNPVPCLLIGTTLWLAIAPVVSSRRGGLRNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVX9</accession>
    <name>A0A2Z5QVX9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86540">
        <property type="protein sequence ID" value="BAV86540"/>
        <property type="gene ID" value="RA11412_0241"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0241"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="24"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="203" mass="21858" checksum="849CA10E7829D6C8" modified="2018-10-10" version="1">MAKDLNVFDKEYGLLINGAWTSPGTLLDSYNPANGEALAKFTDATDADVDAAVAAAQEAFKTWRKTTATERAAILNKIADVIDENLELFALQETLDNGKPIRETRAADIPLASDHFRYFASVIRGEEGTATQLDSEDLSIVLREPIGVVGQIIPWNFPFLMAAWKIAPALAAGCTIVIHPSSSTSLSLLSLAQKLTTCCLKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVZ3</accession>
    <name>A0A2Z5QVZ3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1-phosphofructokinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">1-phosphofructokinase family hexose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_07535</name>
        <name evidence="4" type="ORF">RA11412_0165</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86464">
        <property type="protein sequence ID" value="BAV86464"/>
        <property type="gene ID" value="RA11412_0165"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0165"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="24"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="322" mass="33375" checksum="DDA05FA0C84C1D84" modified="2018-10-10" version="1">MIITLTANPSLDRTIELGAPLAHGAVQRATGAVQDPGGKGVNISRALHISHVPTLAVIPGEATDPVLTGLREVGVEYANLSTGEPIRSNITVVDPDGTTTKLNAPGTHFTPELRQALDQLVVERACAVNDGQQTHWVVLAGSLPPGLDASYYAELVGKLRSAGFTGNIAVDTSEAPLIATARGEHKPTLIKPNSEELAQLTGSDNWRELEASPELTARTARHLVDQGIRYVLATLGGEGAVLISAEGAWWAKHEPVTVRSTVGAGDCSLAGFLIAHELGASPQDALVQAVAHGSAAASLPGTRVPALEATTPQKVTVQALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW16</accession>
    <name>A0A2Z5QW16_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06840</name>
        <name evidence="4" type="ORF">NCTC10207_02285</name>
        <name evidence="2" type="ORF">RA11412_0306</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86605">
        <property type="protein sequence ID" value="BAV86605"/>
        <property type="gene ID" value="RA11412_0306"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0306"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI24848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="79" mass="8965" checksum="30862B1646A565FF" modified="2018-10-10" version="1">MHKDNQGKQSRRQELPLSLWVFALATFVLALPRIGDGRILPIDLTTSSILGAVLIVCGFWMMYREHKKSSAQKDNSHNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW44</accession>
    <name>A0A2Z5QW44_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6318 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86635">
        <property type="protein sequence ID" value="BAV86635"/>
        <property type="gene ID" value="RA11412_0336"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0336"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046281">
        <property type="entry name" value="DUF6318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19843">
        <property type="entry name" value="DUF6318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6318" evidence="1">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="148" mass="16433" checksum="C8C6FA03C5DF3D1D" modified="2018-10-10" version="1">MAGLYSSLAFMIASLQYLFATGDDQYFEQSDLSDEDKRDITKDSSAGDMYRAFREGQAWLGNPTFTAVLEEPQPTKRDDTYHWPVTFTSDLGEYIVALGKVQEFKEAERKHTYKGELTAKYSDGAWRLSDISSQSPGASASASPSSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW64</accession>
    <name>A0A2Z5QW64_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86534">
        <property type="protein sequence ID" value="BAV86534"/>
        <property type="gene ID" value="RA11412_0235"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0235"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="61" mass="6473" checksum="FE4A830D88CC2079" modified="2018-10-10" version="1">MLALLEVVVSGDALGDPLSAVDTLAFDWLVSEDEDFPLLLAEEQALRASIMARAAEIGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW80</accession>
    <name>A0A2Z5QW80_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86667">
        <property type="protein sequence ID" value="BAV86667"/>
        <property type="gene ID" value="RA11412_0368"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0368"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032584">
        <property type="entry name" value="DUF4913"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16259">
        <property type="entry name" value="DUF4913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="174" mass="20135" checksum="D6875DC2D9AF77F7" modified="2018-10-10" version="1">MADGGVRPEDIEWNIDSLGATLVELYNNMSELIDMYEELRDRVYAVETAGGGSTSEPSKYCWRNISDPAEATRLWNELRSWVDWLNFRYFSTGRFRIAPCWYRHGAAVEELTALWASWKAAYQGGDFSDSAFYWHERLFDSSIERLKGYFRECQQGTGRCRSLCISLMMGLMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWB8</accession>
    <name>A0A2Z5QWB8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADA regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86707">
        <property type="protein sequence ID" value="BAV86707"/>
        <property type="gene ID" value="RA11412_0408"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0408"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="130" mass="13769" checksum="08CA0627F90008A2" modified="2018-10-10" version="1">MLQHISLERAKAALAGQQSTLDAAWSSGFSGTGRLHDAFVTVEGMTPGEYKNGGANLRIVWRYAASPFGTVLIAATDKGICHMAFADNPDAALTNLRAEYPNAQLHEGEHPFHEQALSIFGAVGSASPCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWE2</accession>
    <name>A0A2Z5QWE2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I6I94_06370</name>
        <name evidence="9" type="ORF">RA11412_0429</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037233965.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86728">
        <property type="protein sequence ID" value="BAV86728"/>
        <property type="gene ID" value="RA11412_0429"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0429"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT88175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="487" mass="52485" checksum="8EC6CE07A7EF554D" modified="2018-10-10" version="1">MASSLFSRRDPNAPKSRRFIEIVLLVLAVGISSGALYLRNPEEAFGSSSSAWLMGTVVLGVGALILHVVLGLRARYADPFILPIVIVLNGVGLAMIYRIDSDLKYPVGDSQLFWTGLSMLACAVVIYFLRDHRVLRKVTYISLALSLILLVLPLLPIIGQEINGARIWISIAGRTFQPGEVAKITLAIFFAGYLSTHRDLILVAGRRIGPIQLPRFRDLVPVFLAWLASIGVLVFQHDLGSSILFFGLFMAMLYLSTGKTSWLVTGGIGVVAGGFLAYHSISHVHDRIYAWVHAFDNDIYNSSYGGSRQILQGVFGLSYGGLFGRGWGQGRTYLVPYANSDMIITSLGEELGLLGLGAILMMYLVLVSRGYRAALGTRDGFGKLLAAGLSTVMVLQLFVVVGGVTRLIPLTGLTTPFMSAGGSSLVANWIIVALWLAISHSARAPHGVVDFDAPRGIDYGSNDYEPEGATSVLARISTASTEGSQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWI3</accession>
    <name>A0A2Z5QWI3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein MviN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86762">
        <property type="protein sequence ID" value="BAV86762"/>
        <property type="gene ID" value="RA11412_0463"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0463"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="266" mass="28075" checksum="F2BEF3EA9C5232C6" modified="2018-10-10" version="1">MARTDALASAIMAAGTLVSRVLGLVRTVLITVAIGSLSTVGDVFEVANTLPNLIYVLVAGGAFNAVLVPQIIKAAKAQDGGALYISKLVTLTVTAIGLITVIMVACAWPIIDVMGSTWTPEQKQLGVIFSLWCLPQIFFYGLYTVIGQVLNAKDAFGAYMWSPALNNVISIIGLLVFIVMFGAQNTTINPPLHSVENWTSAQTVVLAGTTTLGIAMQALVLFIPYAAWGCICAPISGGAALDYVNPLNSPLGRLQRALWLTFPSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWJ3</accession>
    <name>A0A2Z5QWJ3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Lipid A export ATP-binding/permease protein MsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I6I94_06460</name>
        <name evidence="12" type="ORF">RA11412_0404</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86703">
        <property type="protein sequence ID" value="BAV86703"/>
        <property type="gene ID" value="RA11412_0404"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0404"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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</entry>
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</entry>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <property type="protein sequence ID" value="BAV87195"/>
        <property type="gene ID" value="RA11412_0896"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0896"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="PTHR12318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="69"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="355" mass="38145" checksum="EC2697F4A9745E0C" modified="2018-10-10" version="1">MRSELYTGAIPVAGSPRVYSGRKSAPAPRTEQVQRLYTIPDFMRTAAETWANEHSGEAAGTAESTGCALKHAASVIFVRDGDDGLETILTYRPGCSPLGIVAFPGGMVTAEDAQNIPWCGADAEHWQRTFAFGDATIAHKVVVAAVRETFEETGLLLAGEDEGSVAEYTAGSDQMNHREAISDRDETLSKYLAMSGLKIRADLLRPVVRWQSPDFCHKRYDVAYFTTAVPVGQQASLLKDKGIWGDWVNVRELLAGRATSDLGDRINQPDTAGKTLDELVTPGVMCTLESLAKVGTSVAWLAKKRTVEVKKPILVKNDGQCMLSFTEVVKAAPRTGKFGAVAAPATSAIPTVTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXL0</accession>
    <name>A0A2Z5QXL0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87066">
        <property type="protein sequence ID" value="BAV87066"/>
        <property type="gene ID" value="RA11412_0767"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0767"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="121" mass="12785" checksum="6D8C7818EDF563BF" modified="2018-10-10" version="1">MLAGAISLRLPEGSANAPGTYADLGFYTAAQMRGRGIMTDAVRTVLGFSFDPLGLGLDTIGWAALVGNAASERVAVKAGFTNITDETSTSAARPDKYGNRKAVAVRQATMTRAQFAEIWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXN3</accession>
    <name>A0A2Z5QXN3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xanthine/uracil/thiamine/ascorbate permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_0804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87103">
        <property type="protein sequence ID" value="BAV87103"/>
        <property type="gene ID" value="RA11412_0804"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0804"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="408" mass="41989" checksum="967CC01CDFDBFEE0" modified="2018-10-10" version="1">MSSENTAAPQAPQTNTTQGALDRYFKITERGSTISAEIRGGLATFFAMSYIVVLNPLIIGLVKDANGHALGVPQVAAVTALIAGIMTIAMGIYAKQPFAMAAGLGVNALLATTILSTPNLTWPQIMGLVVWAGVLMTALVLTGFRTAVFEAVPESLKTAIVVGIGFFIAFIGLVNAGIIRRTVDAAHTTVPVTFGVGGHLLGWPTVVFLVGLFLTIALFIRKVRGAILYGVLASTVLSIILEAVFHIGSSKDNPTGWSLNVPAWGGGSALPDVSLLFSADMFGAFGTIGGMAATMLIFTILISAFFDAMGTTVGLATEAGTIDKDGKIENIDRVLLVDALGSVAGGGTSSSANQIFVESATGIGAGARTGLANVVTGALFVGAVFLSPLVTIVPSRRSPPPWFSWGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXU0</accession>
    <name>A0A2Z5QXU0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome C-type biogenesis protein CcdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87275">
        <property type="protein sequence ID" value="BAV87275"/>
        <property type="gene ID" value="RA11412_0976"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0976"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="137" mass="14496" checksum="D47D8666CAD431A6" modified="2018-10-10" version="1">MGRLSILQVDKRFHTRPGTGLWGAPVLGVTFGLGWAPCIGPTFAAVQTLVFTGGAATFKAVVLTFAYCLGLGVPFLLVAYFAARGVNTTGWASTHKRGIQRAGGAMLILIGILILTGAWNHLMAWVQAALPVYELPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXU7</accession>
    <name>A0A2Z5QXU7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C-type cytochrome biogenesis protein CcsB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Cytochrome C-type biogenesis protein CcsA/ResC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ccsB</name>
        <name evidence="10" type="ORF">I6I94_04145</name>
        <name evidence="9" type="ORF">RA11412_0979</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87278">
        <property type="protein sequence ID" value="BAV87278"/>
        <property type="gene ID" value="RA11412_0979"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0979"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017562">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03144">
        <property type="entry name" value="cytochr_II_ccsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
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    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="8">
        <location>
            <begin position="169"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="386" mass="41807" checksum="C3DC07A85498C803" modified="2018-10-10" version="1">MLNETLARYSELFMYIAALIYTVVFVAFTWDVVKNSRVTRRLEGAAAPREAELEEEQAAEPVTAGAASSVAGAEKTGGKTAAKSSVKMSAKATRVERTGGAETGTGERGAGYRGAAARALEGHVADSSMLYTGQSRPAARIAVIVMLMGALVHAAAVIMRGVAAQRVPWGNMYEFCTTGALVVVAVYLVALIFRDLRFVGTLVSGLALIMMCAATISFATPVGHLKPALQSYWLVIHVSIAVLASGVFTITFAMAVLQLVQTRREQRILNGKSGGWAFMRLVPSAQALENFAFRLNALAFVMWTFTLAAGAIWASQAWGRYWGWDTKEVWTFVIWVVYAAYLHARATRGWAGPRSAWLSIIGYLCIIFNFTVVNIFFSGLHSYSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXX0</accession>
    <name>A0A2Z5QXX0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0877</name>
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    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87176">
        <property type="protein sequence ID" value="BAV87176"/>
        <property type="gene ID" value="RA11412_0877"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0877"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="90" mass="10351" checksum="294CB30C64B51309" modified="2018-10-10" version="1">MVAMLKEVNQNPRHNTMESYKKFEQEVADNPDGFNNLVIEFQYPDPADPTKLTKTERVPEKFEVKWTTAAGEADSRPFENLPPQKRVGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXX8</accession>
    <name>A0A2Z5QXX8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_04460</name>
        <name evidence="3" type="ORF">NCTC10207_00363</name>
        <name evidence="1" type="ORF">RA11412_0894</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888552.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87193">
        <property type="protein sequence ID" value="BAV87193"/>
        <property type="gene ID" value="RA11412_0894"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0894"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI22288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="67" mass="7296" checksum="1C826CB92C65A958" modified="2018-10-10" version="1">MKKWEYATVPLMIHATKQILDSWGEDGWELVTVLPGASAPSGPNPAGNMVAPTQGNPIAYFKREKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXY4</accession>
    <name>A0A2Z5QXY4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical nudix hydrolase YeaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87203">
        <property type="protein sequence ID" value="BAV87203"/>
        <property type="gene ID" value="RA11412_0904"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0904"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="104" mass="11535" checksum="9B56D535B9F5F593" modified="2018-10-10" version="1">MTPVLGWWASPTRVGVVDTNESALIARVPVRDLLNPANRHTAYVKRGRITHKTPAFEVVHSSGDARVEFTVWGFTAIVLDKIFDALSWTVPWDDSVLKPAPALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY10</accession>
    <name>A0A2Z5QY10_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87216">
        <property type="protein sequence ID" value="BAV87216"/>
        <property type="gene ID" value="RA11412_0917"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0917"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022307">
        <property type="entry name" value="Helicase_put_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03817">
        <property type="entry name" value="DECH_helic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="144"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="402"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="894" mass="97234" checksum="9F91185EF2B1627E" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY15</accession>
    <name>A0A2Z5QY15_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prepilin peptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Putative type IV peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_03810</name>
        <name evidence="4" type="ORF">RA11412_1058</name>
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    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
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            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A24 family.</text>
    </comment>
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        <property type="protein sequence ID" value="BAV87357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87357">
        <property type="protein sequence ID" value="BAV87357"/>
        <property type="gene ID" value="RA11412_1058"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1058"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="3">
        <location>
            <begin position="39"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="175" mass="19175" checksum="6A1B216218311EB3" modified="2018-10-10" version="1">MYQEITTLLHGGGWLTVSAVLLILYCLHTLIQGIRLWRVDVREHRLPRSIVYSMVLSTYTALPLVLLMKGDAGAIGRVFLGGAVLWVFYLLMRVLSFGALGRGDVRLALALGGALAYFSMVNLVWASLVTFIVGGMFSLALVLFGMARSGTRVAFGPFMLLGALTGWVWPAYTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY39</accession>
    <name>A0A2Z5QY39_9MICC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87246">
        <property type="protein sequence ID" value="BAV87246"/>
        <property type="gene ID" value="RA11412_0947"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0947"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="39" mass="4495" checksum="C9279C9BDB980C24" modified="2018-10-10" version="1">MWDKPKMGLLFYPVSAKKPQLSNNDAKNWGLTLKTLNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY57</accession>
    <name>A0A2Z5QY57_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0967</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87266">
        <property type="protein sequence ID" value="BAV87266"/>
        <property type="gene ID" value="RA11412_0967"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0967"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="393" mass="43033" checksum="A21D8A12A5858FBF" modified="2018-10-10" version="1">MGRLARRIRAHWRKRHRKREALRTSREFFKRQHTLRRWRLPKQNSSDITPFTGAPSSRTTPAPPKHGLFDSLLPGRKTTDARSTHTGTARRGALTVEASAPGASTHQPRLLDARTYENLRDFIDAKVLSSPARTAISTFLLVIVFFTLMLLLPIASNDGQMAPLHHAFFTATSAVTVTGLTTVSTAEQWSMFGQVIILCACQIGGLGTLTLTSLLALATGRKMGLRSKLIAQEELNIGRLGEVGSVVRTVAYTSASIEAFIALLLTPRFLMLGEDPLTSLWYGIFYAISAFNNAGFTPHSDGIVPYGHDFFVIIPVCIAVFLGLWGSRCSWRCSSTRLNPAGGRSPRSSHSSPPACFSYWALPRGVRPNGITHALSEGTTRGIKYSARSLLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYA6</accession>
    <name>A0A2Z5QYA6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">RA11412_1149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87448">
        <property type="protein sequence ID" value="BAV87448"/>
        <property type="gene ID" value="RA11412_1149"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1149"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="70" mass="7545" checksum="104FA600CC466E8B" modified="2018-10-10" version="1">MRAQRSGNNDKLSWSGAEQGARYQVIRNGRVIATVTGTNYSVAHQDGARYSVRAVDASDNYSAGSPEARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYB5</accession>
    <name>A0A2Z5QYB5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF501 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Protein of uncharacterized function (DUF501)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_03895</name>
        <name evidence="3" type="ORF">NCTC10207_00491</name>
        <name evidence="1" type="ORF">RA11412_1037</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023133788.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87336">
        <property type="protein sequence ID" value="BAV87336"/>
        <property type="gene ID" value="RA11412_1037"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1037"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163">
        <property type="entry name" value="PTHR37163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI22416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="196" mass="21194" checksum="2FCF85732CF1057A" modified="2018-10-10" version="1">MSTKEDLMNRVPEGVGVTVQTLVPTEQDVRVLSAQLGRKVRDVVEVPARCVCGNPLVAATAPRLANGTPFPTVFYLAHPVITAAASRLEAGGLMYEMTDELAQNPQLAQQYRAAHENYLAERERIRIISGTDEVPEIDGISAGGMPTRVKCLHAVIGHTLSVGRGVNPMGDRALDAISPWWTPDTCACDPAWRHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYF3</accession>
    <name>A0A2Z5QYF3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87383">
        <property type="protein sequence ID" value="BAV87383"/>
        <property type="gene ID" value="RA11412_1084"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1084"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008441">
        <property type="entry name" value="AfumC-like_glycosyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05704">
        <property type="entry name" value="Caps_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="307" mass="35772" checksum="88E473ADD1208DB4" modified="2018-10-10" version="1">MRELGQSCVNHFFFKKIKHYIWLNYVKDGAGVDKIRSWYSQKSPYSYDIEKYTHRIKNTAMPNSSTFMVNHLFYDSQLPEDNLQNAPNQIFIVWLGDNQITPARQKSIDLIRSVNSESKVILITSDNLADYVLPEHPLHPSYEKLSYIQRSDYLRAYLMHHHGGVYMDIKPMDKPWLPLLEELNATPDMWVIAPHEIGSWNSSSASGVLGKDQRNYYKSVVNMSAFGCKPYSRFTDEWIAEVNRRMDYFSSLLESYGDPQAFGYMPEYPIPWLELAGRITSPLSLKYIDRIKIVKDMQFGTYPGGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYG0</accession>
    <name>A0A2Z5QYG0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03310</name>
        <name evidence="2" type="ORF">RA11412_1193</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87492">
        <property type="protein sequence ID" value="BAV87492"/>
        <property type="gene ID" value="RA11412_1193"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1193"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="264" mass="27080" checksum="6EB782E17891AB98" modified="2018-10-10" version="1">MFKRTNFLYRLNSTAKVGWSSSITFATVGTALSTLVIVPGLSVLFSVLLGRDLSAPDPVRIACTSALASVALGVAVGVVARAATDRWLGVFEQVCTARRFDAAYWLGVSAMPVLLALITGITNLGVAAAYAGFGGSLEGSLSMLVRSVTLLPLALMAGVCLGVFAAGLGLYLSDPYLGGTILGALLPISAGVIVPVDAYPAWLAALCTLVPGGRTIALVSGSSEMVDSTVVTEVLVCVLWALAGLVLVHAAARRIRSGARTNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYG8</accession>
    <name>A0A2Z5QYG8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Elongation factor Ts</fullName>
            <shortName evidence="6">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">tsf</name>
        <name evidence="11" type="ORF">I6I94_03205</name>
        <name evidence="12" type="ORF">NCTC10207_00635</name>
        <name evidence="10" type="ORF">RA11412_1218</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888995.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87517">
        <property type="protein sequence ID" value="BAV87517"/>
        <property type="gene ID" value="RA11412_1218"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1218"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="9">
        <location>
            <begin position="71"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="6">
        <location>
            <begin position="80"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VEI22554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="276" mass="29342" checksum="8CF6D6C81880D82B" modified="2018-10-10" version="1">MANYTAADIKALREKTGAGMLDVKKALDEANGDQQKAAEIIRVKGLKGITKREGRATAEGLVAARVENGVGYMVEVNSETDFVAKSDPFIAFGQNVLEAAIAANASTLEELQAASYEGKTVEELTTDAGALLGEKIVVRRVARVEGENVAVYLHKTSKDLPAQVGVLLAVSGANTEEIAHDVAVHIAAMSPKYLDSASIPADQVETEKRVARETAIAEGKPEQILDKIVEGRLKGFYKENTLLDQDFAKDPKKSVAQVLSEAGATATGFARFRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYI4</accession>
    <name>A0A2Z5QYI4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-inositol 3-phosphate glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_1114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87413">
        <property type="protein sequence ID" value="BAV87413"/>
        <property type="gene ID" value="RA11412_1114"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1114"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="184"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="310" mass="33852" checksum="DD95D62A17E30682" modified="2018-10-10" version="1">MARHTLDMARAGIPGYELVVLAPAGVLTERLKELGVRVIEAEFGPHAGFKRSFTSLLRAIEDETPAIVHSHLAYADVLAAAVVNSLKIRRALNRSLVIPKLFTTEHGIAGDDSVYHGTSWRSKLMEQVHRVRLWGTDTAIAVSASTAEQMRRKWGARTVELVYNGVDIDAVRAQVDAYRVPAEPDAPRILSLSRLSPEKGIDVLIDAFARLHEHYPKARLEIAGDGELSAALKEQAQRLSLGDSVTFSGFIDPHRAMGRSDMVVQLSVWENCSYTLLDAKSAGLKVVATAVGGNPEVVSARELVERSSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYP1</accession>
    <name>A0A2Z5QYP1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87572">
        <property type="protein sequence ID" value="BAV87572"/>
        <property type="gene ID" value="RA11412_1273"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1273"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="109" mass="12332" checksum="389859315C32BDB6" modified="2018-10-10" version="1">MTAEDLRWWAGITITDARYAFKHARRTQTIVLGGQEYAVGSWQEGVTRSELRDALNRELSLPAFDEYLLGYADKSFALREELRPQVLTWNGMSWDFTLAAGEATGRAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYV8</accession>
    <name>A0A2Z5QYV8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-coenzyme A carboxyl transferase alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87471">
        <property type="protein sequence ID" value="BAV87471"/>
        <property type="gene ID" value="RA11412_1172"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1172"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="39"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="308"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="558" mass="60461" checksum="89C9DA73B451A420" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ65</accession>
    <name>A0A2Z5QZ65_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Diaminopimelate epimerase</fullName>
            <ecNumber evidence="4">5.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_1281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87580">
        <property type="protein sequence ID" value="BAV87580"/>
        <property type="gene ID" value="RA11412_1281"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1281"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="233" mass="24948" checksum="0583DD5F5555FA56" modified="2018-10-10" version="1">MSENASAWADLTGRTLTKGQGTGNDFIFITDPKAEAVLDADLVARVCDRHFGLGADGFIRAAHTETFSTGQKILEKHPEATWFMDYRNADGTISEMCGNGVRAFVEYLRTEGLISLEVGEHVSIGTRAGVKTVARTDTGYAVDMGPWSFIHGDAAREGGEDSQVSARGLKTPRPALSISMGNPHTVVMLGSDGKLDGLDLGVAPVVTPARRTARMWSSWCLSNWSMTPAILGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ82</accession>
    <name>A0A2Z5QZ82_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
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    </evidence>
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</entry>
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            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
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                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 5">FDAARGOS_1137</strain>
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    </evidence>
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    </evidence>
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</entry>
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    <name>A0A2Z5QZC8_9MICC</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="55" mass="6781" checksum="7B786B4FD2AA5CBD" modified="2018-10-10" version="1">MKRDKPYFFVFIDSKETIAILSKNNKFIFITVFDNNFFIFEIYEFKFIFIVILQP</sequence>
</entry>
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    <accession>A0A2Z5QZE0</accession>
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        <name type="scientific">Rothia aeria</name>
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    <reference evidence="8 10" key="1">
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 10">JCM 11412</strain>
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    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 11">NCTC10207</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
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    </dbReference>
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        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
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    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
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        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MIP"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="VEI22680.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
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    </evidence>
    <sequence length="267" mass="27100" checksum="7A39C15E280AC1B9" modified="2018-10-10" version="1">MSIPLAAAVGTLLADGGSALADTAGKANTLGLFVSEFFGTFILILLGAGVCAAVNLPKSYAKNAGWVVITFGWGLAVFTAVYLSFPSGAHLNPAVTLGLASAGRDLAENVPASAANIAIYIAGQMLGGFCGAVAAFLAYKKHFDEEKGDRLGIFATGPAIKSYGWNLVTEILGTFVLVGWIIASGKTPAQIGPLGVALVVVVIGMSLGGATGYAINPARDLAPRFAHFVLPIRGKGGSNWSYSWVPVLGPTIGGVLAGLIVPALLAL</sequence>
</entry>
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    <name>A0A2Z5QZK2_9MICC</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87925">
        <property type="protein sequence ID" value="BAV87925"/>
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    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1626"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="512" mass="54868" checksum="979BB3AE49F8EB8E" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZK3</accession>
    <name>A0A2Z5QZK3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">RA11412_1603</name>
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    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87902">
        <property type="protein sequence ID" value="BAV87902"/>
        <property type="gene ID" value="RA11412_1603"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1603"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="166" mass="18447" checksum="E901D02145367E61" modified="2018-10-10" version="1">MTVHPIVIHGNPVLHRPAAPVTAFDEQLKELIADMYETMDASHGVGLAAPQIGVGLRLFTYQMENEDGVPPRGVVVNPVLTLGKISGADPDPDTEEEGCLSFPGYGFPLKRAEWVTVTGFDGEGNPLRFEATGWFARCMQHETDHLDGKLYVNRLNKKWTSRMKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZY1</accession>
    <name>A0A2Z5QZY1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_01980</name>
        <name evidence="2" type="ORF">RA11412_1521</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87820">
        <property type="protein sequence ID" value="BAV87820"/>
        <property type="gene ID" value="RA11412_1521"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1521"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="291" mass="31284" checksum="77B7C1739FD946CB" modified="2018-10-10" version="1">MTHTIPNFEYTVYTPEHPTQQALVLMIHGFATRGDQLWGGTGWVRQYLRAGYTVIAVDLPYHGRGWLKDPSFSVAAKLPPETAVQVGTLAPAPDGADTTDAMGALVEALTRLLDGLQESGNTTSQRHPVHVVGFSFGAHLGWDLAVAHPHLVASLVLGGLPLCDHLQDLKVLFDGGTIDDTETLQAFTNIISSSPIRQEALHRFVALSFAPFDPDAIRGGQRPRCPILMAVGTEDNVAADAHELYDMVASDNPRNELLLLPGRDHVNALTAGVFRRAALAFSQGSEAAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZZ9</accession>
    <name>A0A2Z5QZZ9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FtsX-like permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I6I94_01900</name>
        <name evidence="10" type="ORF">RA11412_1541</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888661.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87840">
        <property type="protein sequence ID" value="BAV87840"/>
        <property type="gene ID" value="RA11412_1541"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1541"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="823"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="882"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="924"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="21"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="315"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="858"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="699"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="751"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="960" mass="98416" checksum="8CD1B5952ABB11B0" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R013</accession>
    <name>A0A2Z5R013_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87881">
        <property type="protein sequence ID" value="BAV87881"/>
        <property type="gene ID" value="RA11412_1582"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1582"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="47" mass="5087" checksum="360F9C37FE222EE4" modified="2018-10-10" version="1">MRGTRRGAYNTRTAAGLIPTYAGNTAKALAPYRHGQGSSPRMRGTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0C2</accession>
    <name>A0A2Z5R0C2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_01345</name>
        <name evidence="2" type="ORF">RA11412_1671</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87970">
        <property type="protein sequence ID" value="BAV87970"/>
        <property type="gene ID" value="RA11412_1671"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1671"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="405" mass="44717" checksum="5EA44D384F45C0FD" modified="2018-10-10" version="1">MRFPDYEHSTQTNTPPEADTATVEQILEAYNKGNLDTLLNVLARRPRELAQQLNRICRAFPAELERVAVVLQQVGDQLPVETLVRLHNQYANAARGVGECLSMDNLRMVHLIQAPMITRSHAARLLLAIEMCLVGRMEGFSVEMPPQDYYRPMKAEPAPTSCNPALDGAINPFTPALWEPFRLGGSDEAVALSATGVREVPNGYELSVLLLDDDYTQVKTIERGVEDTCFSCFWDEEGVDSENDIRCGLTLGYRIEEYAEVNVHRAMALGVRYVVVTARVGERFPQFGSADNPGKAPQGSPVHPDTPRFTSQVAPDIRSLTITPEATIRPVEHRGNFHVLDAPGRTVCAVLDLYKQRISTPAVGIPEGADEDTTLTAIMGVLNGYLPMTVREFMRLSGAAVRKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0C3</accession>
    <name>A0A2Z5R0C3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88215">
        <property type="protein sequence ID" value="BAV88215"/>
        <property type="gene ID" value="RA11412_1916"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1916"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="192" mass="20821" checksum="47A5485F6703078F" modified="2018-10-10" version="1">MPNDNIDRAIKRGAGLTGETIDYTEIMYEARGPQGTALYIECLTDNRNRAASDVRLAVTRNGGTMADQGSVAFLFERKGVAEVAKTDGLTEDDVLMAVLDAGAEEVLDEGDVFTVVSAATDLPEIRKALDEAELEYNNDDPVFRPTMQVDLDLDGAKKFLKLADAVEELDDVQNVYSNANVSAEVIAQLEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0E3</accession>
    <name>A0A2Z5R0E3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Shikimate 5-dehydrogenase I alpha</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Shikimate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00545</name>
        <name evidence="2" type="ORF">RA11412_1889</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88188">
        <property type="protein sequence ID" value="BAV88188"/>
        <property type="gene ID" value="RA11412_1889"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1889"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="1">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="308" mass="33134" checksum="1BCD9BBAF79471F5" modified="2018-10-10" version="1">MKQEPYREAPYARRAYVLGHPIGHSLSPALHRAAYRYVGDDDLEYQRRDTVREDLPGIFTEVNHPAGTPEAPYIAGLSVTMPLKTAVIEYCDELTELARITGAVNTVYVNGLKVIGHNTDVAGIVNALLQAGLDPAPQRERPAVVGGGATAISALTALHRLGYGGVDLYARSLHKLADVHTVADRLGVQVAPQPLAQFPAAASAYNPVISTLPAHAADAWAQDMGELTAGSLLLDVAYDPWPSLLASEWEKRGGTVVSGLEMLLYQAVEQVLIFTRRTPNDTEKLGMLNAMCAAVGLAPREHLPQTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0I2</accession>
    <name>A0A2Z5R0I2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding protein Era</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88237">
        <property type="protein sequence ID" value="BAV88237"/>
        <property type="gene ID" value="RA11412_1938"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1938"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="4">
        <location>
            <begin position="192"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="288" mass="30922" checksum="C8D014A10ECB6DAC" modified="2018-10-10" version="1">MNDLVAGTLSQVDVLGFCIPANEKIGPGDRYIASQLVAASNKPVVAIVTKADTVGNEQLTEQLLAVQALGEEVMSAERASRAQRATHRTKQGSSPKKARKNDAVPFAKGSGPAARRAAGTVQEEPLPVDGKGGWADIIPVSAVQDFQVDAVANLLASYTPTSPPLYPAGELTDEPEATLIAELVREAALEGAREELPHSIAVTVEEMEFRQGRPEHNPLLDVHVNLYVERDSQKAIIIGKGGSNLRKIGAKAREQIETMLGTRVYLGIHVKVAKEWQSDPRALNRLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0N0</accession>
    <name>A0A2Z5R0N0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00120</name>
        <name evidence="2" type="ORF">RA11412_1998</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88297">
        <property type="protein sequence ID" value="BAV88297"/>
        <property type="gene ID" value="RA11412_1998"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1998"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="77" mass="8241" checksum="23F6CC3BC615E110" modified="2018-10-10" version="1">MSTAILAHGAGAEHADGMLLGLPTYMYGVIAAVVFAVLLLITLSYSGRGIVRPDHAPEAFDDEEAKLLKEYNSRHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0S0</accession>
    <name>A0A2Z5R0S0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88086">
        <property type="protein sequence ID" value="BAV88086"/>
        <property type="gene ID" value="RA11412_1787"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1787"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4411" checksum="7D8A0CEFB84D694A" modified="2018-10-10" version="1">MTSRGVPGVPCKHRQYAGARPSPRWDAPGACVHEVSEYTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0S1</accession>
    <name>A0A2Z5R0S1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88385">
        <property type="protein sequence ID" value="BAV88385"/>
        <property type="gene ID" value="RA11412_2086"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2086"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="128" mass="14091" checksum="4C32D6858A80BAD1" modified="2018-10-10" version="1">MRTIQRNVDAVVRACSVSGLNPQVKVRHSSARTYLSGALDVWDIVFVDPPYALPNEQVVEDLQQIAPHLAEGAIVVVERSARDSEPVWPKSVRRFAAKNHGETAVYYLEPDAAELSAEPVLGIAEKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Z4</accession>
    <name>A0A2Z5R0Z4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88455">
        <property type="protein sequence ID" value="BAV88455"/>
        <property type="gene ID" value="RA11412_2156"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2156"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="277" mass="30984" checksum="27F73A5598D709E7" modified="2018-10-10" version="1">MYSRIRGGELLVPSITTVIGQHATDLSGWHSYMAAKAALEDHRTYRASGSQGLKFAIIKDASAASERYRDAAAERGDRVHNYAENIALRAMGKPHDVETCREHLIRNGEQAYADRFDEWWDAFRPKPLAAEITIWNDTVGYAGTLDLVAEIAGRTCIIDYKTKGTDRKGRVKPLDAKVVMQLVAGLKAEEALIDPDTGEWEPWQYGDAPILMGVALGETQVVPHQANPRILEKNWRKFCALRRVWEYNRDVNEFDDAALMPVIPPPAPKAQPHHNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R108</accession>
    <name>A0A2Z5R108_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_00655</name>
        <name evidence="1" type="ORF">RA11412_1865</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88164">
        <property type="protein sequence ID" value="BAV88164"/>
        <property type="gene ID" value="RA11412_1865"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1865"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT90038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="377" mass="43471" checksum="BE5FD85376FB03EA" modified="2018-10-10" version="1">MWTFPHYPPGKLPNWQALEHRFSWFADMKNVPQDPEWHAEGDVFVHTKMVCEALLQLPEFQTLSEQEQHILFAAAMLHDVEKRSTTKREIQGGKERIVSPNHAKKGEYTARSLLYTELATPFAVREAIAKLVRLHGLPLWAIDKPSPERAVIAASLQVNTAHLAMLAKADVLGRICRDQQDILLRIDLFRELCEENGCWGKARNFASDYGRYLYLNGRRDMPDYQPFDDRTFDVYAMCAIAGSGKDSYIRQHLANLPILSLDDIRRERKLDPANPKHSAEAVRLGKEQAKEYLRARTSFVFNATNLNRDLRSKWLPMFADYGARVHLIYLEVPYTQLLSQNRNREHSVPNDVIHRMINKLEIPDYGEANTVDFVVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R114</accession>
    <name>A0A2Z5R114_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">23S rRNA (Uracil-5-)-methyltransferase RumA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88475">
        <property type="protein sequence ID" value="BAV88475"/>
        <property type="gene ID" value="RA11412_2176"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2176"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="217" mass="23539" checksum="4EC8045FC27E9348" modified="2018-10-10" version="1">MTEDVTFGARRFSYQVSAGGFWQVHRCAPSALVGTMLTMLRPAEGECTLDLYAGAGLFTAALADAVGERGTVVSVEGSPVTHRDARANFAPDGAARSESAKGTRIEVIHGDVARTLLDLKTALELDELPHIDAVVLDPSREGAGKKTLERLNKLSPGRILYVACDPAALGRDTAILRELGWDLVQVRGYDMYPNTHHVEAAALFYRAPARIKPRRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R117</accession>
    <name>A0A2Z5R117_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4870 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_06995</name>
        <name evidence="3" type="ORF">RA11412_0270</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86569">
        <property type="protein sequence ID" value="BAV86569"/>
        <property type="gene ID" value="RA11412_0270"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0270"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="161" mass="17658" checksum="DFBF6297790550E0" modified="2018-10-10" version="1">MSQQNFDPNQPNYNYNPNMQQGMGQQPYEQEAPDARSMATFAHISPVLSLFAPLIFWFIYKDKTGYGRTKAAAARAFNLALTWTIVAIVYIIVCAVIFGAGAAASTARNVSPLVGIASLMYLLIIPAGLVVLIFHIVAAVKTNKGEDYKYPVPTLKVLKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R192</accession>
    <name>A0A2Z5R192_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88442">
        <property type="protein sequence ID" value="BAV88442"/>
        <property type="gene ID" value="RA11412_2143"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2143"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="61" mass="6385" checksum="85D57E4CD11C9C2D" modified="2018-10-10" version="1">MHLLNEGVPSPTTSRMRALSSAALMAWSMSVLMRGLLTRGAGVGRGVFGGTGRSMIDGFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1C5</accession>
    <name>A0A2Z5R1C5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86689">
        <property type="protein sequence ID" value="BAV86689"/>
        <property type="gene ID" value="RA11412_0390"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0390"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="SSF54518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="132" mass="15229" checksum="855939C8EE59C285" modified="2018-10-10" version="1">MRTLHIQQQALKITDHYIIYDDLGRGVYQVDEEFRMMGKKITVLNLETGVSFMFTRQGGFTNEFYVAFSTGALVNIKKHFAFFQLKLDVESNCAPPMQVRDRYLGREFNVRTEEAIVATINKSTSQSATSMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1H7</accession>
    <name>A0A2Z5R1H7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">murA</name>
        <name evidence="11" type="ORF">I6I94_11025</name>
        <name evidence="10" type="ORF">RA11412_2101</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88400">
        <property type="protein sequence ID" value="BAV88400"/>
        <property type="gene ID" value="RA11412_2101"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2101"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="9">
        <location>
            <begin position="11"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="476" mass="51216" checksum="D0101942AF7B9138" modified="2018-10-10" version="1">MTLNISKLRIDGGTPLKGQVTVRGAKNLVPKAMVAALLGSTPSVLRNVPDLSDVEVVTILAELHGAKVDYDRETGVLTLTPDHNSQTAERNAKDIQLFGGNSRIPILMVGPLLHTIKTARIPNLGGCKIGDRPIDYHLNALRKFGANVTKDDASGITLEVPEDGLKGTDIELTYPSVGATEQVLLTAVRAQGKTVLKNAAIEPEIIDLIAVLQKMGAIIFVNDNRTIVIEGVDELTGYDHTALPDRNEAASWASAALATGGDIFVRGADQQDMTAFLNVFRKAGGRYEVIDHGKDKGIRFTHPGGELKPVVFETDVHPGFMTDWQQPLVVALTQAKGTSIVHETVYENRFGFINPLKQMGADIVVLRDCIGNVSCRFYGKSFGHSAIINGPTALMADNFQVPDLRGGFSHVIAALAAKGTSEVSGVEVIARGYENFEQKLKDLGATFEVLERKASEAPKPDAKIDVPTPETVEVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1M0</accession>
    <name>A0A2Z5R1M0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88685">
        <property type="protein sequence ID" value="BAV88685"/>
        <property type="gene ID" value="RA11412_2386"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2386"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="162" mass="17988" checksum="E909836AEDA9767C" modified="2018-10-10" version="1">MVFQSFNLFAHKTILDNVTLGPRKIRKLPKAEAEAEAMKLLAKVGVESQAEKMPAQLSGGQQQRVAIARALAMKPKVMLFDEPTSALDPEMVNEVLDTMVSLARDGMTMIVVTHEMGFARKAADRIVFLADGEIVEEATPDDFFTKPKSERARDFLSKIIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1T3</accession>
    <name>A0A2Z5R1T3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAC2 family</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">PAC2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_10545</name>
        <name evidence="3" type="ORF">NCTC10207_01490</name>
        <name evidence="1" type="ORF">RA11412_2231</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887388.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88530">
        <property type="protein sequence ID" value="BAV88530"/>
        <property type="gene ID" value="RA11412_2231"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2231"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008492">
        <property type="entry name" value="DUF774"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028754">
        <property type="entry name" value="UCP028754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI23383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="302" mass="34128" checksum="36AEE277EC28EF31" modified="2018-10-10" version="1">MLNPDDLYLAKNSILSDERLRDLPLVVAFSSPQDAGATAGQFGTFLLDNLKHVAIAEFDSDQLHDYRARRPHIVFNRDHFEDPVFPKLKLYVVEDSLDKPFLLLTGSEPDFQWQRFQQAMLGIAQRLQPSLVVFISAFPMPVPHTRPVPVTAHGSRKDLIDGISAWRPKAELHANMTNLLEVLFTEHGFDTVGFGVNVPQYISDADLPQGTLAALEYVTMATRLSLPTDQLREAARTVHGQINEQMAQHPEVQSMVSSYEENYDANYRSSNMLIPLSQRDADKVLGRDEIGALFEQFLHERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R210</accession>
    <name>A0A2Z5R210_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88748">
        <property type="protein sequence ID" value="BAV88748"/>
        <property type="gene ID" value="RA11412_2449"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2449"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="95" mass="10316" checksum="01B7B1A8F4C11852" modified="2018-10-10" version="1">MGEWTAAADAADLTPEELHRHPTSHEELWCFDLMGFPSGTGEMSPSAAAPWGELYEEVGEAQWGALLAWVETGCYVADVDGLPCASDFEDRYCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R217</accession>
    <name>A0A2Z5R217_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ispH</name>
        <name evidence="7" type="ORF">I6I94_09570</name>
        <name evidence="6" type="ORF">RA11412_2459</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88758">
        <property type="protein sequence ID" value="BAV88758"/>
        <property type="gene ID" value="RA11412_2459"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2459"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="254"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="361" mass="39122" checksum="355D5B44CDDB3860" modified="2018-10-10" version="1">MSVETISLGLPPVPKVRRTREDVEAAAPVTGQKRVLLATPRGYCAGVDRAVIAVEKALEHYGAPVYVRKQIVHNRHVVETLEKQGAIFVDEVDEVPEGSVTVFSAHGVSPAVVSAAGQRQLNTIDATCPLVNKVHREAVRFAKQDYDILLIGHTGHEEVEGTAGEAPDHIQIVNSPDEVGAVTVRDPEKVVWISQTTLSVDETLETVARLRERFPSLQDPPSDDICYATSNRQGAIKEIAPQSDLVIVVGSANSSNSVRLKEVALEYGAKRAERVDFAHQVDESWFEGVATVGLTSGASVPEVLVQEVLALLADYGYESIEEVETAKEDILFSLPKELRAALKNDENTGRQLGGRGAKPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R246</accession>
    <name>A0A2Z5R246_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NCTC10207_01502</name>
        <name evidence="2" type="ORF">RA11412_2247</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88546">
        <property type="protein sequence ID" value="BAV88546"/>
        <property type="gene ID" value="RA11412_2247"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2247"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI23395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <sequence length="158" mass="18127" checksum="4441DD9A507D4163" modified="2018-10-10" version="1">MSEFIAKHFDELTAHELQQIHIIRSLVFTVGQQSTDQEPDDADFECIHMVNEDESGKVLAYLRLFDLEKVQDARHRYIPGAWTFGRVAVHPDARGTGLGRKLLHAALEWIRDNTDAKEIVIAAQAYLKDTYYSPEGFVERGEHYMESGIEHVEMVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R254</accession>
    <name>A0A2Z5R254_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88773">
        <property type="protein sequence ID" value="BAV88773"/>
        <property type="gene ID" value="RA11412_2474"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2474"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="4761" checksum="66D133492CF71CB4" modified="2018-10-10" version="1">MASRAGATALLCGWVFSTRCCVGGHKNLVMFCAWGVFWHTDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R273</accession>
    <name>A0A2Z5R273_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88793">
        <property type="protein sequence ID" value="BAV88793"/>
        <property type="gene ID" value="RA11412_2494"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2494"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025409">
        <property type="entry name" value="DUF4303"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14136">
        <property type="entry name" value="DUF4303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="125" mass="14168" checksum="D8C88E8B2D11F910" modified="2018-10-10" version="1">MLQKMVTEAVIHDFYGLQKLAGEKTIYGCALVTDSDFGSVFMSMNTVREAGDPTSYDWDIYSWEYTSDQLNNSKLPRVSKKLWRLLDRSGDSLQDTVLPVFVQALKHLQQDVARTGCDTDTICFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2A2</accession>
    <name>A0A2Z5R2A2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LpqB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88601">
        <property type="protein sequence ID" value="BAV88601"/>
        <property type="gene ID" value="RA11412_2302"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2302"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016458126" evidence="3">
        <location>
            <begin position="31"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="4">
        <location>
            <begin position="195"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="313" mass="34504" checksum="06CBA17E2FA2CA9F" modified="2018-10-10" version="1">MNQQNISAVTGIVSSSTSRRRFLGVGAAAAATVLLGACAGIPTSKNVHRYSDKLEVRENKNQAIHAVGPQEDAPPEAIIEGFIHAGVDSADNYAVARQFLTSDFKGKWNPTTTTRVYRNTAQVSADESSSGVYRARFQQTTLVSEQGLTSSFAETLETFDFKLRQIEGQWRIEACPDGLWLDSVEFDRVFSPYRLYFYNSMYTHAVPDIRWFAHRDGQLGILLQTVMGGPASYLKEVTASTLVEGMSLERAEVSDRDAKIHINGPVLNAVTRARLRQQVGYVLSNFSSVNKFELTYNGSVVSEDAPTGFQEAP</sequence>
</entry>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="93" mass="10195" checksum="ADC4724E485557FD" modified="2018-10-10" version="1">MRTEEGLIEAHIVADAFCHHMVRSIIGALVLYASGKRTREWLRGLIDSPARDASLTLAPPQGLSLAEIYYPAPEEYGAQAERARRMRTAATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
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    <name>A0A2Z5R2F4_9MICC</name>
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        <submittedName>
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    </protein>
    <gene>
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    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87079">
        <property type="protein sequence ID" value="BAV87079"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core3" evidence="1">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="138" mass="15132" checksum="1E12D85B31F87744" modified="2018-10-10" version="1">MGDNPTTATDAHTVSSIKARLAVCAAKIIARLPVTVIVRLLKMFRPLQKSSSIQQALAVDAKVREVSPLCRGERGCLARSISTYLLLSLMRRKVVWASGFRVKPFLAHAWVTVEGEPINEHHDVQGFVTVASTNPEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2N0</accession>
    <name>A0A2Z5R2N0_9MICC</name>
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        <submittedName>
            <fullName evidence="1">TsaD/Kae1/Qri7 protein</fullName>
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    </protein>
    <gene>
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    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88810">
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        <property type="gene ID" value="RA11412_2511"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="50" mass="5046" checksum="7600458AF7AEFFFF" modified="2018-10-10" version="1">MRLIIPKFTLCTDNGAMVAALGAQLVAAGHEPSGVGFTADSSLPVTTVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2P0</accession>
    <name>A0A2Z5R2P0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable glycosyltransferase</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88820">
        <property type="protein sequence ID" value="BAV88820"/>
        <property type="gene ID" value="RA11412_2521"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2521"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="111"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="269" mass="30669" checksum="8262674F5EF5D210" modified="2018-10-10" version="1">MGIQDNLKKIWDSAYVMKKTWHTKVVHALYLVDLIAIAFSVVSAHIFRFGFEQVDLPPINLWPFSVMGREYIPFDYITLDIIMIIMWWLFLQFNGSRSVRVLGFGTEEYRLVTRGTTYCFCMIIIVAFFLKVEFTRLYMLISYPLGIISLAFMRWLLRQGLVRWRKRGRALTRVLIISDVITGRHLHQALGSVIASGLCPTAFYLPGLPEGTVVAGDNLPVLGYSTDPAKIMQAVQENNIHMVAVSNGHHLTPTRCGSWDGNWLMPASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Q0</accession>
    <name>A0A2Z5R2Q0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89045">
        <property type="protein sequence ID" value="BAV89045"/>
        <property type="gene ID" value="RA11412_2746"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2746"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="50" mass="5683" checksum="A3811AAE01E06B38" modified="2018-10-10" version="1">MPFELKQPQYNATTEQAIAETKAMMEGTRKSKQYSSPRELFAELDAEGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2U8</accession>
    <name>A0A2Z5R2U8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_08815</name>
        <name evidence="5" type="ORF">RA11412_2643</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88942">
        <property type="protein sequence ID" value="BAV88942"/>
        <property type="gene ID" value="RA11412_2643"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2643"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="4">
        <location>
            <begin position="13"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="228" mass="25125" checksum="F546B53419A8EEAF" modified="2018-10-10" version="1">MREDESPSPAQPCLGAIWAQTDAGIIGRDGTMPWRAPEDLAHFKTVTMGKPVIMGRRTWESFPPRFRPLPERTNIVISRSITGDSAAPLKRDGALWVPSLDAALTLAGNTPLTPNTTQHSDAAHQRVTAWIIGGGSVYAEALSREDLPSFGRVEIIERTFFYCQEGNEITGDTYAPELAVEGFVAADEPVRWRILGESAWEKSERGYLLDASGGKNPMYYSFQTLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2W1</accession>
    <name>A0A2Z5R2W1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YrdC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89068">
        <property type="protein sequence ID" value="BAV89068"/>
        <property type="gene ID" value="RA11412_2769"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2769"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="221" mass="25073" checksum="DC442BEF55FFC8B8" modified="2018-10-10" version="1">MATDGEGLERKFDAKQRKRQKPGVVLCGSMEQLEALAQLTPEIRDFYQKHWDEDILLGCILPWREDAEKYLPDETTKELARDTRATSCFVIRFGVPGEQIVRKLWEGGRLTFASSANPSGIGNKGRASGIGERIESSVDLIIRSDEYVKSIQPDKSEETRHEQGVMVSMVDDEGKIVPEQHGERGVTPAPVLIRKGLDYEAIMRHLSDSFPSWDYRHGMYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2W9</accession>
    <name>A0A2Z5R2W9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_09380</name>
        <name evidence="3" type="ORF">RA11412_2502</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88801">
        <property type="protein sequence ID" value="BAV88801"/>
        <property type="gene ID" value="RA11412_2502"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2502"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033777423" evidence="2">
        <location>
            <begin position="32"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="631" mass="68277" checksum="B91934DABC831426" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Z4</accession>
    <name>A0A2Z5R2Z4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-succinylbenzoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88992">
        <property type="protein sequence ID" value="BAV88992"/>
        <property type="gene ID" value="RA11412_2693"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2693"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041338">
        <property type="entry name" value="OSBS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18374">
        <property type="entry name" value="Enolase_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="73"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="283" mass="30095" checksum="7F0103AA2A9B63AE" modified="2018-10-10" version="1">MRVKFRGVTTRHSALIHGPYGWGEFAPFPEYDDAEAAHWLSSALEAAYLPPTVTVREQVPVNATLPAVPAHRVPDVLTNYNGDIQELKIKVAERGQTLDDDIARVAAARTALPNARLKIDANAGWTLPQAFTALTALSDYNLLYAEQPVGSINDMKQLRTQLDNAQVPVLIAADELVRKADDPLTVARAHAADLIVVKAAPLGGVRRASAVIAQSGLPAVISSALETSVGIATGVHLAASLPELPYGCGLGTVSLLNTDVSSTPLWPKTAAYRCGPQPPRRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R306</accession>
    <name>A0A2Z5R306_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89012">
        <property type="protein sequence ID" value="BAV89012"/>
        <property type="gene ID" value="RA11412_2713"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2713"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016402644" evidence="2">
        <location>
            <begin position="28"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV89012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="358" mass="38561" checksum="0113D9DDF489781F" modified="2018-10-10" version="1">MLRYRKNLAIIAAISLALNLQGVGAVADEASSSGTVGNGKFTVTSSKIKAGQEHNYNVVIVAPTQGQGAVPAGQGVPGRQNAPDNGQQAAPEEAEGGAIAGILRCSLQPALEMAGENVTPDYGCTEKPAASDTGNAISRQQQIAARVRDGLDSLDISKPVLHNDFGLHAYTDLNINYYVTQAGVQTKETTILDEKVTIQVIPVSYQYTYGNGAVRTTSSAGAPGTRWDESEKNYTKTSTSYQFEKAGNFHSYVTVVYQARYRIGDNGPWMVAGTTEMRSEAMLLRVWEIDVHNVAKDCREDPYAWACPMNKNHPDYNNPNPKLAHPDPFTGQQWHKDNAGVGDTERGKNPAAENAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R310</accession>
    <name>A0A2Z5R310_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rplN</name>
        <name evidence="7" type="ORF">I6I94_09155</name>
        <name evidence="8" type="ORF">NCTC10207_01770</name>
        <name evidence="6" type="ORF">RA11412_2557</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888745.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88856">
        <property type="protein sequence ID" value="BAV88856"/>
        <property type="gene ID" value="RA11412_2557"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2557"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI23853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="123" mass="13354" checksum="DAE9D3D59892F392" modified="2018-10-10" version="1">MIQQESRLKVADNTGAKEILTIRVLGGSSRRYAGIGDVIVATVKDAIPGGTVKKGDVVKAVVVRTKKETRRADGSYIKFDENSAVILKNTDGDPRGTRIFGPVGRELRDKKFMKIVSLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R313</accession>
    <name>A0A2Z5R313_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08485</name>
        <name evidence="2" type="ORF">RA11412_2723</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89022">
        <property type="protein sequence ID" value="BAV89022"/>
        <property type="gene ID" value="RA11412_2723"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2723"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="515" mass="56361" checksum="CBE5AB4F6D41ED4B" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R343</accession>
    <name>A0A2Z5R343_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Outer membrane stress sensor protease DegS</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">S8 family serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_03885</name>
        <name evidence="8" type="ORF">RA11412_1040</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87339">
        <property type="protein sequence ID" value="BAV87339"/>
        <property type="gene ID" value="RA11412_1040"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1040"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="119"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="499" mass="51290" checksum="F10D616350C98223" modified="2018-10-10" version="1">MATHWNKRHDAQRLGAAQHAETPASKAPLRLAHRAFAVVASLTLSVGVAASGGFNPALAAPTPGSSATASPTPSKSAPTAPEASAPAAINSTSAGDDVRQREYWINDYKFPELWNQSTGRGVTVAVIDTGVDGTHPDLEGNVLKGHDASGVGSSDGWTGLGTEPMHGTEVASLIAGHGHNTTGVAPIAGQPGKPAGIIGVAPEAKILPVSLSMGTGGGKSIDEQLPEAVRYAVDNGAQIINLSIGSNKASWPRSWDDAFKYAEEKGVLVVASAGNRGSGITQVGAPATIPGVLTVGSVDSSRRESWSSSSQGISIAVAAPGVNMIAAAPNNKYMLWSGSSASAPLVSGLAALIKAKYPELSAAQIIQRIITSADDAGPAGRDPLYGFGIINPTAALAEGTSSNAAENPLGSISNWIAIHRKQEVSAPEPTSSEPVHEDGENIPQAKVPEPSVPPEDSGVVPPLIVGGLALWLLAITSFTVHRLHKMHRHVRRPHVRDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R356</accession>
    <name>A0A2Z5R356_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89004">
        <property type="protein sequence ID" value="BAV89004"/>
        <property type="gene ID" value="RA11412_2705"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2705"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="145" mass="17050" checksum="ED29F0640C84A34C" modified="2018-10-10" version="1">MEPDEFGRIIELEDTIEESDIFTRYSEYIDRVIEFTERSVIPLSEQPEVLRECVGYTRAYRCGSIDAADLERRRLELMKKPYAQKQEEAIAAYMDFLLWFEFLDGTTPNGSRIAIPPTCWMACTRYSTVWRCVRNCTHTLWAQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R383</accession>
    <name>A0A2Z5R383_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetylneuraminate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87409">
        <property type="protein sequence ID" value="BAV87409"/>
        <property type="gene ID" value="RA11412_1110"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1110"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006190">
        <property type="entry name" value="AFP_Neu5c_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036732">
        <property type="entry name" value="AFP_Neu5c_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013132">
        <property type="entry name" value="Neu5Ac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03102">
        <property type="entry name" value="NeuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51269">
        <property type="entry name" value="SSF51269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50844">
        <property type="entry name" value="AFP_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="AFP-like" evidence="3">
        <location>
            <begin position="404"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="458" mass="50016" checksum="D95C8CCC640ED776" modified="2018-10-10" version="1">MIIERNIAPYVVFAEDPILTALHKISANGQRIIFLVNESGILRGSLSDGDFRRWLIANPTASLETSALAAANTNPQTAPADSDPESLRSYFARGIEHIPLIDERGHLVALAMDEQNVLRIGKHTISEDAPAFIIAEIGNNHQGSVDFAKELVDLAVESGADAVKFQLRDLDALYRQRGGATAGEDLGVQYTLDLLSRFSLSVEQMYEVFDHVKEHGLDILCTPWDAPSVQALVDYGIAGMKIASADLTNHELLRDVASRGLPMLVSTGMSREEEILDSVNLLRKAGASYALLQCQSTYPAPFKDVNLAYMDRLAEIGQCLVGYSGHERGYHVPVAAVARGAKIIEKHFTTDKTLEGNDHTVSLLPEEFAAMVRQIRDIEESIGTAAPREVSTGELMNRVNLAKSLVATRSIAKGEVITEADVTVKSPGRGLQPNYLPQLLGRTIQRDVEEGSFFLRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R384</accession>
    <name>A0A2Z5R384_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein rarD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_2677</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88976">
        <property type="protein sequence ID" value="BAV88976"/>
        <property type="gene ID" value="RA11412_2677"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2677"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF114">
        <property type="entry name" value="PTHR22911:SF114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00688">
        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="9">
        <location>
            <begin position="13"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="320" mass="34498" checksum="560E22CB111D1DE7" modified="2018-10-10" version="1">MAADNRAPSHMRTGLFYAIITYLMWGMLPLYFNLMADASPVEIVASRVVFSLIFCAALLPMLKLTGGFVEVLRNRRATLVLFAASLLIGVNWFIYVLATTTGRTIDASLGYFINPLVSVSLGVIFLKERLRVAQWVAVGLSAVAVLIMSVVYGQVPFIGLGLAFSFGIYGLLKSRVGGTVAPVVSLSLETLLLIPVALLALVWVQGTGQSTMFTTPGRFLLLASTGVVTAVPLIAFAAAAKRLPLTVIGMVQYVGPSIQFFLAVFVLKDHIGAEKWLGLSIIWVALVIFTADAVRASRTSRLSRTADPETGMVPIVQREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3L9</accession>
    <name>A0A2Z5R3L9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1304 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_02660</name>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Gronow S."/>
                <person name="Severitt S."/>
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                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAV88799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="213" mass="23756" checksum="A66498528F01293E" modified="2018-10-10" version="1">MTDEAIGVPSGTNRAMSEWTWQDYLSWGQEINQERMEADWKGLWDYAPPNTGASEETLARTEAQLGFRLPKSYRDFLKVADGWPCFYQDMTIFSTSDLLGGELRRLGGVQLELEECIEAMASDGVIAADHFMVAAAQGSIDIVLMGRPGTPAEGTASWVRGEVLGRYDDLLDYYLSMMEYNKLETADLRKDFGPKPDGVPHAVLDTRPNEGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVA4</accession>
    <name>A0A2Z5QVA4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86317">
        <property type="protein sequence ID" value="BAV86317"/>
        <property type="gene ID" value="RA11412_0018"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0018"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="312" mass="33481" checksum="2A1EEFEEBE9B7E7F" modified="2018-10-10" version="1">MTSERFSADTFVVSGGRPAHEHDAPVNPPIILSSTYRGTDTVDTVNDRVYARFANDTWEGMEEVVARLEGATQPGLLFPSGMAAVASVIDLVPVGSVILVPKHAYMASVTMCKDLERRGIAEVVRYDLEDTASVIAALEDAAARTGVTPGTVDYAAPKALIWIESPTNPMLEVGDVPAICAAAKRLGVVSAVDNTFSTPLVQRPLSFGADVVVHSATKFLAGHSDVLLGVSVTSNEALYQAMLHHRITNGAIAGPMEAWLGLRGLRTLAVRVERSMANAQVLAERLGSTRLWCRCVTRGCPLIRGMSWRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVJ5</accession>
    <name>A0A2Z5QVJ5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4031 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07705</name>
        <name evidence="2" type="ORF">RA11412_0116</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86415">
        <property type="protein sequence ID" value="BAV86415"/>
        <property type="gene ID" value="RA11412_0116"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0116"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025109">
        <property type="entry name" value="DUF4031"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009218">
        <property type="entry name" value="HD_phosphohydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174">
        <property type="entry name" value="PTHR21174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13223">
        <property type="entry name" value="DUF4031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4031" evidence="1">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="306" mass="33616" checksum="E49F3F4CC9ADB24E" modified="2018-10-10" version="1">MSIFIDPPLWPAHGTFFSHLISDTSLKELHDFAAAHEISPRAFDADHYDVPQHRYTALVNAGAQEVTGTQLTRILIRSGLRVPLKERPSKIRPRLLRAWEALAPGASAVGADLLERWEQPHRAYHNSVHLSEMLAALTLLYSPKPVPRTVLFAAWFHDAVYEAQPGQDEAASAELVRTNLMPLTRTGVLTAAEVTAAAQLVEFTASHRVPEELAGLTGGVLTRADADFFMDADLAILAAETARYGRYIAGVRTEYSHYGPQAFAQGRSGFLREFLGRDRIFASAAGHSLWDAAARANMAAELESYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVL7</accession>
    <name>A0A2Z5QVL7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86416">
        <property type="protein sequence ID" value="BAV86416"/>
        <property type="gene ID" value="RA11412_0117"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0117"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="88" mass="9419" checksum="68DF6F16D590624B" modified="2018-10-10" version="1">MQYQSPKSSSDQEFTYLAVGMVAGAIPGIIIGLLLAIPLGNPAMWVSITGGIGIVIGMVTGKFIYRKKYSNQPQSPSEGPQHPNDKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVU7</accession>
    <name>A0A2Z5QVU7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86518">
        <property type="protein sequence ID" value="BAV86518"/>
        <property type="gene ID" value="RA11412_0219"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0219"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="136" mass="15481" checksum="D6AAC0AEB25F1051" modified="2018-10-10" version="1">MRNALGDPTAVYYQPDANTHVEAESQATHTNGVLIDLARREVFLDGEPLMLTFKEFELLAHLVENSSRTVGRDELLDSLWSAGDEHPHERTIDVHIRRLRSKLGRLSGTVRTVRGQGYRFFEHPEVVVWAAPEYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVY4</accession>
    <name>A0A2Z5QVY4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86542">
        <property type="protein sequence ID" value="BAV86542"/>
        <property type="gene ID" value="RA11412_0243"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0243"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="5308" checksum="DCE9597D555FE860" modified="2018-10-10" version="1">MVDFFNNCLFFGEFIQYSSDFDKHKIVRQTLDREVIDWEEDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVZ1</accession>
    <name>A0A2Z5QVZ1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86552">
        <property type="protein sequence ID" value="BAV86552"/>
        <property type="gene ID" value="RA11412_0253"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0253"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009200">
        <property type="entry name" value="DUF1269_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06897">
        <property type="entry name" value="DUF1269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="172" mass="18323" checksum="D59AB98F077BFA46" modified="2018-10-10" version="1">MIKKENGLIIPAESTDFTANTAESAWTGGLIGSLVGILGGPIGVLLGGAIGALIGSDAGTAQTLGEGSLLENTAKKLDNGSTAIIILAQESNEAVLDAFFHRFKTVILRQDAAVAQQDVLAAIEAQEEVARQAHEVWKKQRKAERKAERQEKVEAFKADIKQKFDELAAKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW13</accession>
    <name>A0A2Z5QW13_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type II restriction enzyme MjaIII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86523">
        <property type="protein sequence ID" value="BAV86523"/>
        <property type="gene ID" value="RA11412_0224"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0224"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="46" mass="5422" checksum="EB1338E4B06D0983" modified="2018-10-10" version="1">MKYNEYMGSAPEEKLKYFLSTLSITNRTPEYYVNWEKVNGGVKNMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW47</accession>
    <name>A0A2Z5QW47_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)H-quinone oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07345</name>
        <name evidence="2" type="ORF">RA11412_0215</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86514">
        <property type="protein sequence ID" value="BAV86514"/>
        <property type="gene ID" value="RA11412_0215"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0215"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="335" mass="34560" checksum="BD824D137032CCBD" modified="2018-10-10" version="1">MRAIMEETHGAPEVLRVSEQPIPEPAPGQVLIRVRAAGVNRADALQRRGYYPPPPGVSSIYGLEAAGTVVAVGAGVSPQMVGSPVAALLAGGGYAEYVAVDARHTFGVPEGMSFAEAACLPEVAATVYSNLVLTCGMSLDAAAHRVSGTSVLIHGGAGGIGLHAVQLAKAVGARVFATVGTGAKADSVRAAGAEPIIYSELSFREVIAEKTGGVGVNYILDVVGGAYLDDNLHSLATGGHLAIIGLQGGAKAQVNLGLMLTRRLSVHATSLRTRSADEKTRIMAGVRQQVLPLVESGAIRANLDRTFALEQADQAHTYFDSGEHRGKIVLTLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW56</accession>
    <name>A0A2Z5QW56_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multi antimicrobial extrusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86573">
        <property type="protein sequence ID" value="BAV86573"/>
        <property type="gene ID" value="RA11412_0274"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0274"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="488" mass="51325" checksum="2CCFC2EE1CFAC18D" modified="2018-10-10" version="1">MHETTDNTPASRAAEILESGDERNIYYLKSAPPMRALLALGIPMATGLAITSIYNVVNSYFVGHFGTVEDLAALIFGFPVIGVITALAGLFGVGASTLTARLLGENKADRIPEVTSFALYASLLFGVLLALIGVFFIDPLTHFMGASGATYEPTRWFVTILFIGAPPWMCMFTLEQLVRAEGYAKQSMYGLAWGVLANLVLDALLIGVLHMGAAGSGWALMGSNLACIIYYMLFLTAKSKNFSVSPRDFKLSADVLKPVLAVGSSQLVSSLFLVASALVLNNLAVKYGDAAVASFGVSIRLIMVPETLCMGICMGGIPLFAYAYGARNRERLRASLRTAVALSVGTSAVFSIPVWFFRDWALYLTGGPTLVEAGDKVLTALLCSTVFHALVVLWISWFQACGKGTAAVVMTASVGVFFFVTVLAGEALFGFDGLTWAFPVTQMASCALGVVLFAVTGRTRVPATAPDAGASASAEPGGQAAGSVGAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWE1</accession>
    <name>A0A2Z5QWE1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_06330</name>
        <name evidence="3" type="ORF">RA11412_0438</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86737">
        <property type="protein sequence ID" value="BAV86737"/>
        <property type="gene ID" value="RA11412_0438"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0438"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="70" mass="7842" checksum="9AC8FEDCB39569EB" modified="2018-10-10" version="1">MGEQPSDSAETPKPEVTNPANLAPVDPQQPREKREDIRAAIFETKLRRWALIGFVAAGALFWVVTLLLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWH7</accession>
    <name>A0A2Z5QWH7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpmH</name>
        <name evidence="7" type="ORF">I6I94_06155</name>
        <name evidence="8" type="ORF">NCTC10207_02427</name>
        <name evidence="6" type="ORF">RA11412_0478</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI25118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887407.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86777">
        <property type="protein sequence ID" value="BAV86777"/>
        <property type="gene ID" value="RA11412_0478"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0478"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI25118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="45" mass="5281" checksum="784B9E344D7C6D00" modified="2018-10-10" version="1">MSKRTFQPNNRRRAKKHGFRLRMRTRAGRAILASRRSKGRAKLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWI0</accession>
    <name>A0A2Z5QWI0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86768">
        <property type="protein sequence ID" value="BAV86768"/>
        <property type="gene ID" value="RA11412_0469"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0469"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="174" mass="18998" checksum="AC066D49370993A6" modified="2018-10-10" version="1">MSSVKQVTNATFDAEVLKSSKPVIVDFWAEWCGPCRLVAPVIEEIAAEYEGKVDVVMVDVEENGDIALKYNITSIPAIHLFKDGELVKPTVGAKAKKLCSQNLQSTSTKSLRTLGADVSRETSAPIVFLALYPHLFSSGHMICTGDRYTVYCNRKPPSPASPVLARTAPCRRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWK2</accession>
    <name>A0A2Z5QWK2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86807">
        <property type="protein sequence ID" value="BAV86807"/>
        <property type="gene ID" value="RA11412_0508"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0508"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025159">
        <property type="entry name" value="AbiEi_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13338">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="338" mass="39044" checksum="470BFD719A742A3F" modified="2018-10-10" version="1">MVWLDVEKLAGEQHGLFTSAQAVNLGVNRAMITRKKQQGAIEQIRYGVYALASAPSDPHQEIRAAWLSLEPSQTAVQRIVNHEGPILCGTVAAEIYEAGVFYTERYDFYSSTRKQSRDEHIRVRLRNLEKEDTETVDGMLVVSPTVLVCDFLEEYYDLNDVTTLIRDLVDSRRKINWNRVEETAQKVSEGYGIPTEEIFEQLFAPALEVSSAIKSTDPNNEQYLPVEMNKYIVENWSQRMQEINRSLRESLKPIIQMQIPKINVDVRALTETRKSLDGMVKNLAPQLSEISKRSKEIQDNMHPTLVRMQRVLKITHYLLPVLIMLIRHVRMLKYDPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWL3</accession>
    <name>A0A2Z5QWL3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06080</name>
        <name evidence="2" type="ORF">RA11412_0493</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86792">
        <property type="protein sequence ID" value="BAV86792"/>
        <property type="gene ID" value="RA11412_0493"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0493"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340096" evidence="1">
        <location>
            <begin position="38"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="326" mass="35336" checksum="D5FAE4A310D8A2C3" modified="2018-10-10" version="1">MPSTPKNRPRRMSRRSLLLGGGCVAAAGFVVFLPAIASTGVLGEEAAATASNSKRLAKWEREIRGNINTEYLVLEDIGRIYIGESEDEDSQRLVARIGLTDAGQDDISAAAAALAALGEYGRPHRVSIVQDEETPVIDVYRFASITETEWGKILRAAQSYKGKSSDALEATTSTEEGVVVTARITTGPWTEGIKRFKDLKTVKLPEQVTARYRLNLKDTPLPSGANAEVRVDVVGTEHVPSVAGALEAAAKRGDFRTLTSFSFVWLGDTAQQKDRALRLDFRRDNEPKNLAAGCRKYLSKWLSKLPAGTEASAYHGGAKIDNNSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWL9</accession>
    <name>A0A2Z5QWL9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">recF</name>
        <name evidence="7" type="ORF">RA11412_0482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5 6">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecF family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86781">
        <property type="protein sequence ID" value="BAV86781"/>
        <property type="gene ID" value="RA11412_0482"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0482"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0742">SOS response</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV86781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="378" mass="41762" checksum="029AB268D3F46E88" modified="2018-10-10" version="1">MTVFLGPNGVGKTNIVEAIDYTANLSSHRVSNDAPLVRVGASRAYIRTRTVRGSQQTVTEFEVVPGHSNRVRINRAAPVRAREALGIARTVLFSPEDLQLVRGEPAARRRFVDDLAVSLRPAVAGYRSEYERILRQRNSLLKSMQRRRTGAASADENAMSTLAVWNEQLAEVGSQLLAARFRVLRVLLPQLKRAYAGLTDGSKDVSLTYESTVFPSVTERGLEHAARMRPEEFKVAILRCFEERRSEEIERGITLVGPHREDITLLLGGLAVKQFASHGESWSFALAMRLASWFVHLEDDPSPGSSPILILDDVFAELDAARRHRLGALVREAEQVLITCAVLSDIPEELGAYRIVTVSPGTAGYAGEQNLSDGKTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWN7</accession>
    <name>A0A2Z5QWN7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86790">
        <property type="protein sequence ID" value="BAV86790"/>
        <property type="gene ID" value="RA11412_0491"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0491"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="83" mass="8888" checksum="91ECA9BF4E981067" modified="2018-10-10" version="1">MFFGAGLPALYAFGMRLLSGTTEYTADGQLIEIEPPSTASRMAATVVFAIIVGIVFIGILWVAKDFIYHTFGWNVFGVTGGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWP0</accession>
    <name>A0A2Z5QWP0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86801">
        <property type="protein sequence ID" value="BAV86801"/>
        <property type="gene ID" value="RA11412_0502"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0502"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="8">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="134"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="7">
        <location>
            <begin position="361"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="491" mass="52216" checksum="62392C55CECC2A25" modified="2018-10-10" version="1">MTTTAAPQWDTLPVHAQEVRRVREAFIEAYGREPDGVWSAPGRLNLLGEYIDFLGGSCMPMPLPYRTYVAGSLRRDGVLRASSLQMPGDERTVVVRDIQPGHLKGWFTYVAGVAWAMNHEGGRDIVLPPDFGADLLINSRVPVGGGLSSSAALECSTALALLDLSCPLRPGCPEADELPSDRSPGNDALRARLAQVCITAENKVAGAHTGGLDQTASLRSKPGQALVVDFRDFSIDPVRVNAAENGLSFLVIDTKTPHELTDGGFAVRRAASESCAQALGLRFLRDALPQDLSCAGLGERAAKQWRLDLVDSSVNRALAALEERGTPADFPRGWVRHAFHDMALVGRASYLLKNADSLGAAAFGEAGRIFTESFVSMRDELRVSRPQIDVAVDACLAHGALGARIVGGGFGGAVMALIPTDRLGEAAQAVAQAYAEHGFAEPRFLPMVAGFAADHDWPEHSSALGREGILSKAVPAGVSRQPARVLYPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWP7</accession>
    <name>A0A2Z5QWP7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86832">
        <property type="protein sequence ID" value="BAV86832"/>
        <property type="gene ID" value="RA11412_0533"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0533"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="167" mass="18318" checksum="237BFDA487B0ACEF" modified="2018-10-10" version="1">MNADGTWVNKTGEKEFTLHADGSWESTEKLSNSKTVIHVNPDGSWSIQEQGKENKEPSNKAEVRADGTWEVDELGVKYVGKADGTATKKDSKADEEKPISRSEWPDIFPKYVASLYKEDGSLVTSVPKDGVIPLKPRTALPLGVSAKKLYPKLMNTAGTLLSLKAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWR0</accession>
    <name>A0A2Z5QWR0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator transcription factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_05925</name>
        <name evidence="5" type="ORF">RA11412_0522</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86821">
        <property type="protein sequence ID" value="BAV86821"/>
        <property type="gene ID" value="RA11412_0522"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0522"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV86821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="215" mass="23895" checksum="C84712E0C4A35DBA" modified="2018-10-10" version="1">MRIVIAEDQFLLRQGLENLFTRHGFEVVAAVDDGPSLTDAVLIHRPDVALIDIRMPPTFTDEGLRAAVQIRKQIPGQPVLILSQYVERLYVDELHMDGGLGTGYLLKDRVFDDAGFVRSVKAVAAGGVVVDPETLKELMEHRAVQQRLERLTSRELEVLTLMAEGLPNGDIAEKLFVAEKTVAKHINTLFAKLDLPDTNSNARRVQAVLHLLRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWT5</accession>
    <name>A0A2Z5QWT5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86897">
        <property type="protein sequence ID" value="BAV86897"/>
        <property type="gene ID" value="RA11412_0598"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0598"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="3901" checksum="6FE96FDF1C134A47" modified="2018-10-10" version="1">MRTAKNDPFLNLPNRSTPLGASMTGCARRPSTPLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWW6</accession>
    <name>A0A2Z5QWW6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86935">
        <property type="protein sequence ID" value="BAV86935"/>
        <property type="gene ID" value="RA11412_0636"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0636"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="39" mass="4519" checksum="9FA64AD808E03225" modified="2018-10-10" version="1">MVIGIMLLILGTPYILYIILQIISAIMYQRGKLLAWPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWY3</accession>
    <name>A0A2Z5QWY3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asp23/Gls24 family envelope stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05490</name>
        <name evidence="2" type="ORF">RA11412_0648</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86947">
        <property type="protein sequence ID" value="BAV86947"/>
        <property type="gene ID" value="RA11412_0648"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0648"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="182" mass="20073" checksum="7C1BA57489B643F5" modified="2018-10-10" version="1">MSSSTRIPHAEPQHAQSAGSLSQAHELDEASTREYLRLIASLHKTWDTLESQSSASVMPQRHMMDAVIAETRHGAQIEMPPTDLGPYSMSEFSLRALVRRSVDSVPGARALRSSFKHAPAPEGHRGLGMPDTIFCRISAHVTTSSLPQLAQQVRDAVRQACYENLELSPTVNIHIEDLHDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX39</accession>
    <name>A0A2Z5QX39_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05215</name>
        <name evidence="2" type="ORF">RA11412_0708</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87007">
        <property type="protein sequence ID" value="BAV87007"/>
        <property type="gene ID" value="RA11412_0708"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0708"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="198" mass="21741" checksum="51608078F0DFF3D7" modified="2018-10-10" version="1">MPDAFTIRPAAPNDAQEVARIRVLGWRFAYQGLVPQGYLDSLNVAEDTERMCGYLSQLPQNLPPNNIASVQGPNDGEKRSFMLAVRDDAVLGFCHFSAAPNNADRPGRTTPGGEMVGRLHSLYVGPDALGQGIGHALMNHALSTFTAWGCKRAHLWVLEGNSRASSFYERQGWQLTGETKVDRSFGPELHEQEMAICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX40</accession>
    <name>A0A2Z5QX40_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">gyrB_1</name>
        <name evidence="10 13" type="synonym">gyrB</name>
        <name evidence="13" type="ORF">I6I94_06130</name>
        <name evidence="14" type="ORF">NCTC10207_00005</name>
        <name evidence="12" type="ORF">RA11412_0485</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI21944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887411.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86784">
        <property type="protein sequence ID" value="BAV86784"/>
        <property type="gene ID" value="RA11412_0485"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0485"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="452"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV86784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT88132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VEI21944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="674" mass="74978" checksum="F330F4CE045CF8F2" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX70</accession>
    <name>A0A2Z5QX70_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoU rRNA methylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86926">
        <property type="protein sequence ID" value="BAV86926"/>
        <property type="gene ID" value="RA11412_0627"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0627"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="108" mass="12445" checksum="B54B9E6029694BD4" modified="2018-10-10" version="1">MSSPSRQTPLDPSDSGQDSRVNESAEPQNTPQEYPESEAFGTPRFEVGVGPWEGEWPEGDHWDEQLLREGDRRNVVDKYRYWSMEAIIADLDTRRHDFMSRSRTGSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXA1</accession>
    <name>A0A2Z5QXA1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome-c oxidase</fullName>
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    </protein>
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        <name evidence="1" type="ORF">RA11412_0657</name>
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    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
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            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT88007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86956">
        <property type="protein sequence ID" value="BAV86956"/>
        <property type="gene ID" value="RA11412_0657"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0657"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="49" mass="5888" checksum="2D0E097E99C83F67" modified="2018-10-10" version="1">MTYKHEFSSDDWFWLDELGELDPSFFEAIQQLRAASNHYHVPERARGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXA2</accession>
    <name>A0A2Z5QXA2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase I</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_0702</name>
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    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87001">
        <property type="protein sequence ID" value="BAV87001"/>
        <property type="gene ID" value="RA11412_0702"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0702"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="6">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="63" mass="6838" checksum="BD276B07FB8E57D7" modified="2018-10-10" version="1">MVEALEEHLNPRGAIVVVEAEHMCMSMRGVRKPGAKTVTSAVRGQLKNAATRAEAMSLIFSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXB7</accession>
    <name>A0A2Z5QXB7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Drug resistance transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Multidrug efflux MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_04940</name>
        <name evidence="8" type="ORF">RA11412_0773</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87072">
        <property type="protein sequence ID" value="BAV87072"/>
        <property type="gene ID" value="RA11412_0773"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0773"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="26"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="527"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="580" mass="60939" checksum="3D237C2489BE07D4" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXC9</accession>
    <name>A0A2Z5QXC9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Single-stranded DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_05740</name>
        <name evidence="3" type="ORF">RA11412_0585</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86884">
        <property type="protein sequence ID" value="BAV86884"/>
        <property type="gene ID" value="RA11412_0585"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0585"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033776938" evidence="2">
        <location>
            <begin position="32"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="423" mass="41579" checksum="1C2F0F477401E0D4" modified="2018-10-10" version="1">MNNNISRRKLVAGAAWSAPAVLATTAVPAYASSTECLPDQSKGGLKKHENYAQELVWDVPADAKELHFEVTGAAGGSFSDDSTGITGIGGAGTTIKGIVRLNGTGKFTFIAGEGGGYNRGNSVNPGKGYGNGGAHGPSLTDRAGENAKEFFGPTGGGASAILFNNEPLVVAGAGGGAGILINQRSNDNQDLYWQMNEPIYGGSGGEKANAAASTAATFVNDTSAAIPANGGQGGEPTGDGGQGGPNPTLRLPSGGAIHAESSQGVSIVNNTIAGQKGGKAGDDRKADGAQSSAQYSSVTLGAETLATIVHSGTGGGGYGGGGSGSVAALAAYQGEGGTAPGVSAPEETKDSAKSTPTEDHAKGETSKGITRPTGAFSAGAFGAGGGAGGSYVDKTVEKGVIAPGENRGVAGQRIHGAIKFWYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXE4</accession>
    <name>A0A2Z5QXE4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_05225</name>
        <name evidence="1" type="ORF">RA11412_0707</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87006">
        <property type="protein sequence ID" value="BAV87006"/>
        <property type="gene ID" value="RA11412_0707"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0707"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="59" mass="7198" checksum="E2753A2589DB5602" modified="2018-10-10" version="1">MNQKLDELYGYIQVSAPEVFHELFRAEENPEKREFYLALFNYSLQSRQRRIIAEEKFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXF1</accession>
    <name>A0A2Z5QXF1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha,alpha-phosphotrehalase</fullName>
            <ecNumber evidence="3">3.2.1.93</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Trehalose-6-phosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_04745</name>
        <name evidence="2" type="ORF">RA11412_0813</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.93" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87112">
        <property type="protein sequence ID" value="BAV87112"/>
        <property type="gene ID" value="RA11412_0813"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0813"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="10"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="627" mass="69892" checksum="37CFB035A8E90071" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXI3</accession>
    <name>A0A2Z5QXI3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87081">
        <property type="protein sequence ID" value="BAV87081"/>
        <property type="gene ID" value="RA11412_0782"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0782"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="161" mass="17552" checksum="521DAB8517B2FFE2" modified="2018-10-10" version="1">MQQESPLILGTLLDNVYISGRGTDSAAAHRILKDLGLEKVLERSGHGVDLNIGGSGTSLSGGEKQRLAIARVILKNPQVYLLDEFTSQLDGISEELVVSVLNNNAAPESTMIMVAHRMSTVVNADMIYVMDHGRIVAQGTHDILMEFSPLYRELVSNQLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXJ9</accession>
    <name>A0A2Z5QXJ9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tadA</name>
        <name evidence="6" type="ORF">I6I94_05015</name>
        <name evidence="5" type="ORF">RA11412_0757</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87056">
        <property type="protein sequence ID" value="BAV87056"/>
        <property type="gene ID" value="RA11412_0757"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0757"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="172" mass="18472" checksum="6C38BC2E91B8D47D" modified="2018-10-10" version="1">MDDEEYAVDAGDSAVLSDAPALPEHQRWMHLALDEARAAAGEGEVPIGAVVIDPAGRVIGSGHNMRERHHDPSAHAEVLAIRAAAQQLGTWRLQGCTLVVTVEPCLMCAGAVLMARIPTVVFGAWETKTGAVGSRYDVLRDARCAPPVRVYAGVLRQDCARVMSGFFARKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXN9</accession>
    <name>A0A2Z5QXN9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_04330</name>
        <name evidence="3" type="ORF">RA11412_0926</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87225">
        <property type="protein sequence ID" value="BAV87225"/>
        <property type="gene ID" value="RA11412_0926"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0926"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340104" evidence="2">
        <location>
            <begin position="32"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="426" mass="43446" checksum="64506989E21615D6" modified="2018-10-10" version="1">MTQEISRRRVVVGTAWAAPAVLASTAVPAYAASSTRLICPKSSRITAAETNYHEIVVPDGAASLYFELVGGAGGYLESYAIGGHGAKVSGALEVTPGQIFKIYLGSSGEAFGTRPAEGGAGYGKGGSSKLSPSSVIPAEEQKILTDLKADNVVIYGGSGGGSSAIVRVDPADPAQETVLVVAGGGGGAGLRGTADDSRNTSDHKRDASWENYGSPYMGMGGDSIHPLHYGGDGWSVDGNFYGYRNYYGFYEGKQLFVHGGKRGYGGIGGKGSEPAELPTIDPFVFKSVEQTPVTIRTMSTTGGIGGDGLRAHGADGVAAYGYAYSTHKFYGDDANASEYVHAVSGYAVSPGGGAGWGGGSSGGVLALGMQKYDEHSGEVYAIGMGVTMGGGGGGDSYISPDIGGTYFTASTDLEPGYLEYGFCFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXV0</accession>
    <name>A0A2Z5QXV0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dnaX</name>
        <name evidence="7" type="ORF">RA11412_0857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87156">
        <property type="protein sequence ID" value="BAV87156"/>
        <property type="gene ID" value="RA11412_0857"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0857"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="36"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="515" mass="56001" checksum="BBEFA046D1743B14" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXZ1</accession>
    <name>A0A2Z5QXZ1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-fuco-beta-pyranose dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_04445</name>
        <name evidence="2" type="ORF">RA11412_0897</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87196">
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        <property type="gene ID" value="RA11412_0897"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0897"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="332" mass="34717" checksum="1329842D0A43536F" modified="2018-10-10" version="1">MIRKIQHNAYGDPSVLEMVETDEPTPGEGEVRVSVKAVSLNPVDLKTFEGYKPLRIAETSNRLRHPSWWFGRGPARFPKGVGRDFSGVIDALGPGVNNIAVGDAVLGTLRSAPGSGVTEGSLAEKLVTSAQNIVAKPENLNFEVAAALGVAGETACGAFRAIDLKPEDVLVISAASGGVGAVAVQLAVHRGATVIGIASEKNAEFVRSLGAIPVAYGDGLKERILKAAPTPVTKILDCYNGDYIPLGAELGLKKDAMGTLIPTPKAMIKGAQFTGARHAQPGDLKEVADLVASGDIDVTLAHVYPFKLTSIRDGYKELGTGHVRGKLVVTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY36</accession>
    <name>A0A2Z5QY36_9MICC</name>
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            <fullName evidence="2">Glutaredoxin family protein</fullName>
        </submittedName>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_04170</name>
        <name evidence="1" type="ORF">RA11412_0972</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87271">
        <property type="protein sequence ID" value="BAV87271"/>
        <property type="gene ID" value="RA11412_0972"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0972"/>
    <dbReference type="Proteomes" id="UP000250241">
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    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
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    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="88" mass="10012" checksum="E881FAC9D2CEBB46" modified="2018-10-10" version="1">MPPATPEPPVIELLTRPGCHLCDAARHTVAQVCAEFGVPYTELNIELYPQLLQRHATEIPVLRIDGQAKDFWRINPKRMRKLIAARMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY38</accession>
    <name>A0A2Z5QY38_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87144">
        <property type="protein sequence ID" value="BAV87144"/>
        <property type="gene ID" value="RA11412_0845"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0845"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="50" mass="5865" checksum="ACC9C790D271E3B6" modified="2018-10-10" version="1">MSSRVAEHVLEEVLTGTEHLAEQAREELPFDSHHMKELLKVLKNRRRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY49</accession>
    <name>A0A2Z5QY49_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87240">
        <property type="protein sequence ID" value="BAV87240"/>
        <property type="gene ID" value="RA11412_0941"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0941"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="584" mass="67049" checksum="C80DBB765D9E18A5" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY52</accession>
    <name>A0A2Z5QY52_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiol-disulfide oxidoreductase resA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Thiol:disulfide oxidoreductase related to ResA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TlpA family protein disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">resA</name>
        <name evidence="4" type="ORF">I6I94_04160</name>
        <name evidence="5" type="ORF">NCTC10207_00429</name>
        <name evidence="3" type="ORF">RA11412_0974</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888252.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87273">
        <property type="protein sequence ID" value="BAV87273"/>
        <property type="gene ID" value="RA11412_0974"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0974"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033777409" evidence="1">
        <location>
            <begin position="31"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="60"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI22354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="205" mass="21832" checksum="AAF15B703C87336D" modified="2018-10-10" version="1">MTPTHNHTRRTALRAGIALCASAAGAGLLAACSEDTSLSKQANSGDNKGYIAGDGSVTEYQEAERGEPVAFTGELFDGTSVNAESLRGKPTLLNFWYAGCSPCRAEAKDLQKLYTDYKDKLGFYGVNVRDEKSTAEAFERSFEITYPSFKDASGKVLLSLSKYVPAQAVPTTVILDSHGRVAARILGQANPSVLKTLIETAVKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYE5</accession>
    <name>A0A2Z5QYE5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trk system potassium uptake protein TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87264">
        <property type="protein sequence ID" value="BAV87264"/>
        <property type="gene ID" value="RA11412_0965"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0965"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="251" mass="26675" checksum="56AB3A1D78219607" modified="2018-10-10" version="1">MANTHNAPVLVIGLGRFGASTAAQLHAQNQEVLAVEKDPELVQKWSGLLTHVVAADAADIDTLRQLGANDFGSAVVGVGTSIEASVLITANLVDLGVERIWAKAITPSHGKILERIGAHHVVYPEADAGRRAAHLVSGRLLDYIEFDDDFAIAKMRPPKETHGFTLAESDIRAKYGVSVVGIKSPGRNSPTQTLHAHSLSGYSYRLGAGGADRAFCCPPVGSAVSLAPLSLLAVLPYRFPPLFSVIKRLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYN6</accession>
    <name>A0A2Z5QYN6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87354">
        <property type="protein sequence ID" value="BAV87354"/>
        <property type="gene ID" value="RA11412_1055"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1055"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="103" mass="10980" checksum="D966A7CD242F2C5E" modified="2018-10-10" version="1">MSLFVLNALFDVTHAVLQAAPEVTPASNPDGSPAGSPGIGGFFATALLSLLVVALGVDMTRRTRRLRYRAQYAAAREAELAAASEHEGKHPTNQLKLGRIPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYU7</accession>
    <name>A0A2Z5QYU7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SMC-Scp complex subunit ScpB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Segregation and condensation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">scpB</name>
        <name evidence="6" type="ORF">I6I94_02710</name>
        <name evidence="5" type="ORF">RA11412_1339</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87638">
        <property type="protein sequence ID" value="BAV87638"/>
        <property type="gene ID" value="RA11412_1339"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1339"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="305" mass="32645" checksum="12E1178A0CE5C5C5" modified="2018-10-10" version="1">MNTSATGGNRFEDEFTESDLNIVNLGYWDPGSDTEIAPDIEQEGTASGADAPEPNNTVETPPQSKGLTVSSLPDKDANKTPSGQRAPRRPSGRTMGAAAVDAEDEFSRVERIPGGVKAAIEAVLAVADAPVSVRELSAALIVNERAVEAALDELYREYNGDESDYGDDGPSREPRGFELRRVGGGWRLYSRADFAPWVARFVTRSQSATLSKSAFETLAVIAYQQPVTRARVAAVRGVNADAAVRQLVHRQLVREAGKEEGTGAALYETTELLLAKLGLDSLDELPELAPFLPDDTEAALLADDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYZ1</accession>
    <name>A0A2Z5QYZ1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="8 9">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 15" type="primary">miaB</name>
        <name evidence="15" type="ORF">I6I94_02975</name>
        <name evidence="14" type="ORF">RA11412_1277</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8 9"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037233184.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87576">
        <property type="protein sequence ID" value="BAV87576"/>
        <property type="gene ID" value="RA11412_1277"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1277"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="12">
        <location>
            <begin position="15"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="154"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="11">
        <location>
            <begin position="387"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV87576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QQT89592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="501" mass="55186" checksum="77671B2A7598BAEC" modified="2018-10-10" version="1">MTISETTESPQTSLRTYEVRTFGCQMNVHDSERMAGLLEASGYVRAAEGEEPDLVVFNTCAVRENASNRLYGHLGQLASVKRRHEGMQIAVGGCLAQKDQNTIIEKAPWVDVVFGTHNIGSLPTLLERARHNHEAQAELLESLEVFPSTLPTKRDHVYSGWVSISVGCNNTCTFCIVPSLRGKEKDRRPGDILAEVQALVDDGAIEVTLLGQNVNSYGVEFGDRQAFSKLLRACGDIEGLERVRFTSPHPAMFTDDVIEAMAETPNVMPVLHMPLQSGSDKVLKDMRRSYRSKKFLGILEKVRERIPHAVITTDIIVGFPGESEEDFQDTLNVVEQARFSSAFTFQYSIRPGTPAATMENQIPKDVVQERYERLVALQDRIAGEENRKQLGKTVELMVVAESGRKAQQTHRLAGRGPDQRLVHFSVPAGCEKPRPGDMVTVPITEAGSFHLISDPTAEQYQLRRTRAGDAWDRSQAESCGAGTTQVSGGPVGLGMPTIGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ44</accession>
    <name>A0A2Z5QZ44_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87636">
        <property type="protein sequence ID" value="BAV87636"/>
        <property type="gene ID" value="RA11412_1337"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1337"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="4003" checksum="60662A98077ABB9E" modified="2018-10-10" version="1">MTYAPFLDASKYLGQVHATCNYRGKPNVTYFTGSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ51</accession>
    <name>A0A2Z5QZ51_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="11" type="ORF">RA11412_1344</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87643">
        <property type="protein sequence ID" value="BAV87643"/>
        <property type="gene ID" value="RA11412_1344"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1344"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="10">
        <location>
            <begin position="9"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="13"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV87643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="236" mass="25170" checksum="DC91D740C7D65775" modified="2018-10-10" version="1">MHEKPKLTIAIDGPSGSGKSSVSKEVARHFGLAYLDTGAMYRAATWYVLERGIDLADAEAISQAVVEMPLVFGTNIKEEEILIGSTDVREQIRSERVSAAVSAVASVPAVREHLIGLQRWAIGHAVNGIVAEGRDITTVVAPDADARILLTASEEVRMARRGLENTEKSGSAGDLTQQISERDAKDSKVNNFMQAAAGVELIDSSELDFNATVSAVINAVNAQVKAKRGDNPRSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ92</accession>
    <name>A0A2Z5QZ92_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I6I94_03105</name>
        <name evidence="13" type="ORF">RA11412_1245</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87544">
        <property type="protein sequence ID" value="BAV87544"/>
        <property type="gene ID" value="RA11412_1245"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1245"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="184"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV87544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT89615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="318" mass="35514" checksum="4288C9F36932F6AD" modified="2018-10-10" version="1">MTLYTELSDIPADFGPSVVTIGNFDGVHIGHTRVISRVVELAEEHGLASVAVSFDPHPMQVHHPELMHQEIMGQGSRRYFMCQLGLQNYVLLHYDLEFAKQSPEEFVKSVFVDTLHARYVVIGDDVRFGHRNSGDLNTMRELGEQYGFEVVVVDDLMADDGTRCSSTRIRELLNTGDMEGAARLLGRPHLMYGEVVHGLARGRELGFPTANLELEARGFIPVDGVYAGWLTDESGTRHPAAISVGTNPTFDGLENRQVEAHVIDRPQERVEDFDLYGQHVVVEFVKHLRPMVAYHGVEALVEQINQDVVQTREVLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZA9</accession>
    <name>A0A2Z5QZA9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87778">
        <property type="protein sequence ID" value="BAV87778"/>
        <property type="gene ID" value="RA11412_1479"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1479"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="55" mass="5846" checksum="0D32EB0657A2D8A3" modified="2018-10-10" version="1">MGTSADHEVVVIGVFTGMIQAEQGVVVGAETFQQGQQFPVDTMVCSVSSLRFPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZC6</accession>
    <name>A0A2Z5QZC6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nrdR</name>
        <name evidence="10" type="ORF">RA11412_1417</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87716">
        <property type="protein sequence ID" value="BAV87716"/>
        <property type="gene ID" value="RA11412_1417"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1417"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="9">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="194" mass="22212" checksum="8C685FDD33C45F1F" modified="2018-10-10" version="1">MYCPYCKHTDSRVVDSRTTDDGAAIRRRRQCTDCGRRFTTVETTSISVIKRSGVTEPFDRAKIASGVRKACQGRPVGEDDLAKLAQEVEERIRAKGLAEINAHEVGLTILEPLSKLDAVAYLRFASVYQAFENLEDFEGPLLCSVKMLWGMRCPRLKHLHRNPARPRRRRPAPKNLKRFLCRIPCYRATLHHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZE8</accession>
    <name>A0A2Z5QZE8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_01990</name>
        <name evidence="2" type="ORF">RA11412_1518</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87817">
        <property type="protein sequence ID" value="BAV87817"/>
        <property type="gene ID" value="RA11412_1518"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1518"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="24"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="215" mass="23491" checksum="D14D5737FAEF72E4" modified="2018-10-10" version="1">MTEAIERVVTHGTFSLDGGTWEVDNNVWIIGDDQHVTIIDPAHDVDKIATKVAGRTVERILLTHAHDDHIRSAKEAAERFKAPVYLNPEDRVLWEMVYPSWDFDEPLHDGQKVSVGATELQVLATPGHSPGSVCFYAPELSWENSEGVLFSGDTLFKGGPGATGRSYSDFDTIIDSIESKLLTLPESTAVLTGHGDSTGIGVEAPDLDAWKKRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZN0</accession>
    <name>A0A2Z5QZN0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87955">
        <property type="protein sequence ID" value="BAV87955"/>
        <property type="gene ID" value="RA11412_1656"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1656"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008327">
        <property type="entry name" value="Sig_transdc_resp-reg_antiterm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036382">
        <property type="entry name" value="RR_antiterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="157" mass="17266" checksum="7E5EBFA088D0852A" modified="2018-10-10" version="1">MSEQTTHDHEGDADAPARTVVVAEDEALIRLDIVEILRERGYEVVAETDNGKTAIELAQKHRPNLVLMDVKMPIMDGITAAEEIGKEQIAPVVLLTAFSQKELVDRAVEAGAMAYVVKPFTPNDLFPAIEVAIARYEQIRALEKKWALSATSSKPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZR5</accession>
    <name>A0A2Z5QZR5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6531 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_01455</name>
        <name evidence="2" type="ORF">RA11412_1649</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87948">
        <property type="protein sequence ID" value="BAV87948"/>
        <property type="gene ID" value="RA11412_1649"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1649"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6531" evidence="1">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="313" mass="35528" checksum="D26CA05C1CD08E74" modified="2018-10-10" version="1">MEGETDFAFEGILPLVWSRSYYSDQDGTGWLGEGWSVPGCQRIIRDAAGLAYIDDQGRLFPLPEVDEDDEEPVLFESEQIWFSKNPDGHYVIASLDGSIALRFAPLVIAEDGSDEDSTLFPLVAVEDANGNHQRFVYHPLTGLPQYVIDGNGWVFSLNFGYVADEQSPKMRLLSVSLLEGLPVFGEAVRVGSPLVRYEYNNSGDLLRVIGRDGNVKRSFGYKNDLMVSHTDAAGLVSEYEYDHYTPTGKVLRNWTSLGEEWRFTYHDGYTEVTDVLGRTEQYHYDYNNELTKRVFCRRQHQSGGMRQATPWYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZS1</accession>
    <name>A0A2Z5QZS1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_01335</name>
        <name evidence="2" type="ORF">RA11412_1673</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023133300.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87972">
        <property type="protein sequence ID" value="BAV87972"/>
        <property type="gene ID" value="RA11412_1673"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1673"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033776861" evidence="1">
        <location>
            <begin position="36"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="247" mass="26982" checksum="C027B5A4090DDDFD" modified="2018-10-10" version="1">MSHIPARTFNRRTFAKGVGWAAPAVVASAAVPAYASSVCETKPPLKFNEKSRWVFQNTGSANLYSRNGFRAITYQQQEFFTSLSTVDYDKSQTDKPQIAVVRGSYEASSTGDAAFNPRCGKYRFKVDLISMRGAAPTENTRLYPTLEIRLIGPDGLTVPGTEQKFTTDPKSTETGVKILPATDAKPPRPQYVTAATPVTFTPKAGTYYFEAKLTAPVNYNHGTGVRDRNMQADGIGVTAPTFEFIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZT0</accession>
    <name>A0A2Z5QZT0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87714">
        <property type="protein sequence ID" value="BAV87714"/>
        <property type="gene ID" value="RA11412_1415"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1415"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="30"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="253" mass="27708" checksum="CCA138151785CF5D" modified="2018-10-10" version="1">MSVNAPAPRDLADIRPEKVDGFSIVYCDDDIVVVDKPAGVAAHPSPGWHGPTVPSALLGEGISVTTSGAAERQGIVHRLDVGTSGLMVLARSERAYTELKRAFKERTVEKVYHTLVQGLPDPLRGTIDAPIGRHPGSEWRFAVVEDGRESITHYETQEAFGPATLVEVHLETGRTHQIRVHFSALHHPCCGDLTYGADPTLSAELGLTRQWLHAHRLGFTHPASGERMSFESPYPRDLTYALEALREGNIRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZZ1</accession>
    <name>A0A2Z5QZZ1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88028">
        <property type="protein sequence ID" value="BAV88028"/>
        <property type="gene ID" value="RA11412_1729"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1729"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="48" mass="5433" checksum="094BBED58C74CFE0" modified="2018-10-10" version="1">MSVEIPEVLRPKMKGSTVLAKNLRALEKLQPHPTELAEKARQHAMELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R050</accession>
    <name>A0A2Z5R050_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="3">2.3.1.180</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I6I94_01660</name>
        <name evidence="12" type="ORF">RA11412_1622</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87921">
        <property type="protein sequence ID" value="BAV87921"/>
        <property type="gene ID" value="RA11412_1622"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1622"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="11">
        <location>
            <begin position="115"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="10">
        <location>
            <begin position="250"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV87921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT89369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="341" mass="35727" checksum="83EDCE5F11238AB9" modified="2018-10-10" version="1">MTTLKQNEMNRYSRILGYGAARGEVLVHNNDIVEAINSSDEWITQRTGISTRHRASENQSVADLAFGSAHDALAAAGVDGADIGAVIVSTISHPYATPSLATLVAEEIGSKCPAYDISAACAGFCYGIAQADALVRSGAAQNVLVIGVEKLSDFIDNTERSISFLLGDGAGAAVVGVSDEPGIAPTVWGSDGSRWGTVGMTHSLLDIRNRDFVQNPVGEGEKIWPTLRQDGPSVFRWAVWEMAKVAQQALEAAGITADELGALIPHQANARIIDQMAKTLKLPESVAIARDIADAGNTSAASVPLAAHRLLRENPELSGTFALQIGFGAGLAFAAQVVVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R061</accession>
    <name>A0A2Z5R061_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP cyclohydrolase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_01625</name>
        <name evidence="8" type="ORF">RA11412_1632</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887888.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87931">
        <property type="protein sequence ID" value="BAV87931"/>
        <property type="gene ID" value="RA11412_1632"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1632"/>
    <dbReference type="UniPathway" id="UPA00275"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="7">
        <location>
            <begin position="56"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="265" mass="28714" checksum="62EE2DE812BFC4E6" modified="2018-10-10" version="1">MSPEPKPAASTGQGWEGLNLPPEQEQAVADAAASYIASPLDTVPMPSPQLIETTYEVPVPTPHGVFGVRAWLFADGAEHITARALNDDGTPTPFTGTGTEPPAPAVRIHSECATGDIFGSYRCDCGPQLENGLRIIAQQGGWLVYTRNHEGRGIGLVNKLRAYRLQDAGLDTVDANLALGLDADMRDYTQASVILQELGAERIRLVSNNPAKVQALAELGVEVLEMIPDEVPARAENTRYLATKRDRMRHQLGPRNTHPNHPHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R069</accession>
    <name>A0A2Z5R069_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="8">IGPS</shortName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpC</name>
        <name evidence="10" type="ORF">RA11412_1637</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TrpC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87936">
        <property type="protein sequence ID" value="BAV87936"/>
        <property type="gene ID" value="RA11412_1637"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1637"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="9">
        <location>
            <begin position="7"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="272" mass="29090" checksum="CB24F6A367AA3FE2" modified="2018-10-10" version="1">MSTSTVLDEIIVGVREDVTQRMEQVPLERVKELALAAEPARDALAALHGDGAKVRIISEVKRSSPSKGALGDIPDPAVLAAKYQAGGAAAISVLTEQRRFGGSLADLDAVRAAVDIPVLRKDFTVDEYQIWEARAHGADMVLLIVAALPEKTLRYFLELTELLGMNALVETHTPDEIETAQRVGAKIMGINVRNLKTLEVNNEHYASLAANLPQSVIKVAESGVSGIEDVTGYANAGADAVLIGEALVKSGDPEAAVRAFRRCLVRSSFIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R089</accession>
    <name>A0A2Z5R089_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87956">
        <property type="protein sequence ID" value="BAV87956"/>
        <property type="gene ID" value="RA11412_1657"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1657"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ANTAR" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="46" mass="5442" checksum="39DEA194710D9CC5" modified="2018-10-10" version="1">MDRAKSLLITKMSLTEPEAFRWIQKTSMDRRLSMREVSDTIIKQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0A7</accession>
    <name>A0A2Z5R0A7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Biotin synthesis protein BioC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88148">
        <property type="protein sequence ID" value="BAV88148"/>
        <property type="gene ID" value="RA11412_1849"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1849"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="60" mass="6615" checksum="3A8C1831D9E50CB9" modified="2018-10-10" version="1">MSTPTGAVNRRGPFRPGERVQITDERGRITTITLAEGGEYHSHRGFLKHDDLIGAPKARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0D6</accession>
    <name>A0A2Z5R0D6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L31 type B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpmE2</name>
        <name evidence="6" type="ORF">I6I94_00960</name>
        <name evidence="7" type="ORF">NCTC10207_01115</name>
        <name evidence="5" type="ORF">RA11412_1784</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887159.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88083">
        <property type="protein sequence ID" value="BAV88083"/>
        <property type="gene ID" value="RA11412_1784"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1784"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00502">
        <property type="entry name" value="Ribosomal_L31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027493">
        <property type="entry name" value="Ribosomal_L31_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VEI23019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="86" mass="9777" checksum="03A919BF67CA28B2" modified="2018-10-10" version="1">MKADIHPEYGPVLFRDLASGKVFLTRSTMTSAKTEKWEDGNEYPIVEVEISSESHPFYTGKQRIMDSAGRVERFNARFANFGKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0E2</accession>
    <name>A0A2Z5R0E2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tmk</name>
        <name evidence="5" type="ORF">RA11412_0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86319">
        <property type="protein sequence ID" value="BAV86319"/>
        <property type="gene ID" value="RA11412_0020"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0020"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
        <location>
            <begin position="13"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV86319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="150" mass="15583" checksum="C562B0901CB508EF" modified="2018-10-10" version="1">MSDGTPTGLFIVFEGSDGSGKTTQLSLLADALTARGYTVITTREPGGTEIGEKLRDLVLSNSGDPVDARTEALIFAASRAAHAAQKIRPALAAGAVVLSDRYIDSSAAYQGRGAAWGWRASLTLAAGPPVTCCQMPPFSLRCRPQQASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0F3</accession>
    <name>A0A2Z5R0F3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Pyruvate kinase</fullName>
            <ecNumber evidence="5 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">RA11412_1655</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 14"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87954">
        <property type="protein sequence ID" value="BAV87954"/>
        <property type="gene ID" value="RA11412_1655"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1655"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 18" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="16">
        <location>
            <begin position="2"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="17">
        <location>
            <begin position="324"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="BAV87954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="464" mass="50644" checksum="5828DA2A72467D49" modified="2018-10-10" version="1">MSRLNMSHGDHDVHTNSYNTIREQSAKLGKEVAILADLQGPKIRLERFKNEKEILEPGADFTITSEEVEGTQEICGTTYKGLPGDVKPGDKLLLDDGKIQLEAVEVTPTRVRTRVIVGGPISNNKGINLPGAAVSLPALTEKDENDLRFALRLGVDIIALSFVRSGKDVERVHEIMEEEGLRIPVIAKIEKPQAVENLQDIIDKFDGIMVARGDLGVELPFSEVPLVQKQAIQMARRWAKPVIVATQVLESMISNPTPTRAEVSDCANAILDGADAVMLSGETSVGKYPIITISAMASIISDTEKKGLYRVPELDRKPRTRGGAITRAAVNIAEQLDVDYISTFTQSGDSARRLARLRPKKPVLAFTPNPKVRAFISLLWGVEAAHAQLTADTDGMTKIVDDYLMEHNLAEKGDLIVMTAGSPPGVAGSTNTVRVHRIGDRDETGAKLPEEREAVRPYADEDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0I5</accession>
    <name>A0A2Z5R0I5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome accessory factor PafA2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Pup ligase PafA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00735</name>
        <name evidence="2" type="ORF">RA11412_1844</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88143">
        <property type="protein sequence ID" value="BAV88143"/>
        <property type="gene ID" value="RA11412_1844"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1844"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022366">
        <property type="entry name" value="Pup_deamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03688">
        <property type="entry name" value="pupylate_PafA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="568" mass="62576" checksum="73D857786793BAC6" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0K4</accession>
    <name>A0A2Z5R0K4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">whiA</name>
        <name evidence="9" type="ORF">I6I94_01210</name>
        <name evidence="8" type="ORF">RA11412_1707</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cell division and chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WhiA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88006">
        <property type="protein sequence ID" value="BAV88006"/>
        <property type="gene ID" value="RA11412_1707"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1707"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018478">
        <property type="entry name" value="Sporu_reg_WhiA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10298">
        <property type="entry name" value="WhiA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WhiA_N" evidence="6">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="LAGLIDADG_WhiA" evidence="7">
        <location>
            <begin position="127"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_WhiA" evidence="5">
        <location>
            <begin position="221"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="338" mass="36222" checksum="0377DC69BBF1E84C" modified="2018-10-10" version="1">MALTALVKEELAQYEASKASVRKAEVSTILRFTGALHIVAGRIVIESEVDTEQTAQRMQQTIAEIYGHESELTSVTGGGLRRGGRYIVRVDSGGEALARQTGLLDLRGRPVRGLPPAVLNGSLQDAEAVMRGAFLAHGSLTEPGRSSAIEFTCPGPEAALALVGAARRLDVMAKAREVRGVDRVVVRDGETIAHLLERMGASESLRTWREQRTRKEVRATANRLANFDDANLRRSAQAAVAAGARVERALHILGDDVPEHLRYAGQLRVANKQASLDELGRLADPPLTKDAIAGRIRRLLVMADKRAQELGIPGTELKEDIQGAEAARGVSSAAPTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Q7</accession>
    <name>A0A2Z5R0Q7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="5">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RA11412_2028</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88327">
        <property type="protein sequence ID" value="BAV88327"/>
        <property type="gene ID" value="RA11412_2028"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2028"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="Fer2_BFD" evidence="11">
        <location>
            <begin position="64"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="10">
        <location>
            <begin position="202"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="9">
        <location>
            <begin position="274"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV88327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="518" mass="56340" checksum="DFE8B36B12D6B841" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0U7</accession>
    <name>A0A2Z5R0U7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Threonine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_00235</name>
        <name evidence="4" type="ORF">RA11412_1974</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887305.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88273">
        <property type="protein sequence ID" value="BAV88273"/>
        <property type="gene ID" value="RA11412_1974"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1974"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="348" mass="36849" checksum="C8E9CAA707F0AC02" modified="2018-10-10" version="1">MRSVIMEEPGKVVVEDRPMPTLLESTDAVIKLAASCICGSDLWPYRGAQPEPVDHQQMGHEYIGEVIEVGDDVKTVKPGDFVVGSFCISCGECATCRDGYPSRCLKAIAAGDGFIGMRSNGTQAEYARIPFADGTLIKTPAYPTAEQIPHLMAASDVLGTGWYAADAAKAGPGKAIVVVGDGAVGLGAVIGAKQLGAEKIIMMSRNPKRQELAKQFGATHVVEERGEEGIAKVLELTDGVGAHGVVEAVGTQQAFDQALGCVRHGGYIGFVGVPHDSSIGTDVLFDKQVHLEGGPAPVRKYLPTLIDLIYKGEIEPGKVFDLVLPIDEAPKGYEAMDQRTATKVLLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Z7</accession>
    <name>A0A2Z5R0Z7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88323">
        <property type="protein sequence ID" value="BAV88323"/>
        <property type="gene ID" value="RA11412_2024"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2024"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="212" mass="22960" checksum="34F6F55EA5D3612E" modified="2018-10-10" version="1">MSSINNYRKNPAIALTGKEPAYGNDSKGNGTIMRSGWLGALPFDRETATVLSILQSETTHEHMLAAVSAAFFTNLTHRILSGQLVRREQIFTAATIICGELQNLVEGTPFAYLQPGIMLVQQAVNNIELSWADLICALQGGRNPNAFFGEGWVAEEALFNVLGVFSAFRSSKDGILALVNTPEILTRLRQLVGACTGLFGGMRRSAQLLAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R109</accession>
    <name>A0A2Z5R109_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyruvate dehydrogenase E1 component</fullName>
            <ecNumber evidence="2 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">aceE</name>
        <name evidence="13" type="ORF">I6I94_10915</name>
        <name evidence="12" type="ORF">RA11412_2129</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037235140.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88428">
        <property type="protein sequence ID" value="BAV88428"/>
        <property type="gene ID" value="RA11412_2129"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2129"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02017">
        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035807">
        <property type="entry name" value="PDC_E1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="10">
        <location>
            <begin position="147"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="11">
        <location>
            <begin position="490"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV88428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT88996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="912" mass="101121" checksum="9F0344777C0EE8F5" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R131</accession>
    <name>A0A2Z5R131_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88353">
        <property type="protein sequence ID" value="BAV88353"/>
        <property type="gene ID" value="RA11412_2054"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2054"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="303" mass="33196" checksum="E10754D45581EA39" modified="2018-10-10" version="1">MGKLKNDEAHPTQNLMTMLNLTPTEPVGGDEAFSAVTLTRESPRTYGGQVLAQAIMAADSTVTDKVLHSIHAYFLRPGDITKELIFTSQRLNDGRSFATRRVQALQDDIPIFSAIASFQAPSRGPEHTAATMPQAPDPEGLPSVSDYIGEVPHPVAQAVAWERPIDIRYVSPHLYTASDSSSQEPVATVWFKTFDTLVDTTGTPASEAAHQAAIAYASDYLPLEPALRAHGKFWLEPGMKSASLDHAMWFHRAAPADEWLLYVLDSPTAQGGRMLARGSIFTRDGELVATIAQEMMFRLPEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R153</accession>
    <name>A0A2Z5R153_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ruvC</name>
        <name evidence="16" type="ORF">RA11412_1915</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88214">
        <property type="protein sequence ID" value="BAV88214"/>
        <property type="gene ID" value="RA11412_1915"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1915"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAV88214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="252" mass="26775" checksum="B8535B95CD9F5821" modified="2018-10-10" version="1">MPGHTPHTRAVSRAPYSIWAHPGGDSQRQHKEKPDERKPPACPEPRVPGATRIMGIDPGLTRCGISMLDMTADRKAYFVNVGIAGTQAAEALDQRILRIFNATQQWIKVYKPDALAIERIFAQEQVNTVIGTAHASGAVISAAAMLGVPVHFHTPSEVKAAVTGSGRADKGSVGRMVTRILGLEKMPKPADAADALAIAICHGWRGGGIGSGINMAAHTQTHQGSRPVQAARGAALTPAQRAWKEAEAKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R169</accession>
    <name>A0A2Z5R169_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metal-dependent hydrolase YbeY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_1942</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88241">
        <property type="protein sequence ID" value="BAV88241"/>
        <property type="gene ID" value="RA11412_1942"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1942"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
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        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="4820" checksum="6DB5F9DB452F60D1" modified="2018-10-10" version="1">MHGILHCLGYDHGTAAEEAEMFGIQRSILEEFLGRPAPVETRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R183</accession>
    <name>A0A2Z5R183_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88507">
        <property type="protein sequence ID" value="BAV88507"/>
        <property type="gene ID" value="RA11412_2208"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2208"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="556" mass="63289" checksum="6F25C8F2D14305C4" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1H0</accession>
    <name>A0A2Z5R1H0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="2">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_2204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
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    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88503">
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        <property type="gene ID" value="RA11412_2204"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2204"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProt"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
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    <feature type="domain" description="TOP4c" evidence="5">
        <location>
            <begin position="23"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="592" mass="64830" checksum="1DDD4A4723B04CEA" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1N5</accession>
    <name>A0A2Z5R1N5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88436">
        <property type="protein sequence ID" value="BAV88436"/>
        <property type="gene ID" value="RA11412_2137"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2137"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
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    <dbReference type="InterPro" id="IPR042099">
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    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="383" mass="42020" checksum="452629B38AFAF859" modified="2018-10-10" version="1">MGTVLAASGRRSGRYRRPEGHRDPEYLARVTAEQDITCVHFVPTMLAAFITSPTARRVLKSAGFGPQETERRLRYLVCSGEALQKDQVLGAHRVLGAYPLNLYGPTEAAVDVTFWDTAEDPEREIIPIGEPVWNTGTHILDRAGRPVPPGITGELYLSGVQLAQGYVNNPQATASAFGQDAPSGMRVYRTGDLAAWEILPGATDDKPPRGVIVYRGRSDNQVKLRGQRLELGDIETVLTSLHSVTGAVALLYTGLREPALAAFLEVGALSTEQREEIIADARQACERNLPDYMVPSLWHTMETLPVSASGKADRKQLAQFRFATAAADARGPHGLLEQQLCTIFARVLGRERFGTTEDFFAAGAIRWRRLRLLPLLASSWDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1P2</accession>
    <name>A0A2Z5R1P2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lysine-specific permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_2406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88705">
        <property type="protein sequence ID" value="BAV88705"/>
        <property type="gene ID" value="RA11412_2406"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2406"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="9">
        <location>
            <begin position="35"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="506" mass="53975" checksum="CA918DE3037FD778" modified="2018-10-10" version="1">MRGTNKEEKYVPTSEEKAANSPEETELKRGLSARHLQMIAIGGAIGTGLFVASGKTISTTGPGGAIVAYGLIGIMVLFLMQSLGEMAAHLPVPGSFQTYATRYVSSSFGFTMGWNYWFNWAITVATELVAVGEVMKYWLPETPSWVWAGTFLVLLTGLNALSAKAYGEGEFWLATIKVVTVIVFLIAGIAMIFGILGGASPGVSNWTAGDAPFVGGPIAIFSIFMVAGFSFQGTEMIGVAAGESKNPRRDVPRALTSVFWRIMLFYIGAMVIIGFLIPYTDPNLLTAAEGDINISPFTLIFERAGISFAAAAMNAVILTAVLSAGNSGLYVSARMLFSLAQEGKAPKVFTKVNKGGVPMPALMATSAVGAIGFIASIISQEAAYLWLVNVSGLAGFITWVGIAVAHYRFRRAYVRQGHSLNDLPYVAPFFPVGPIIAFIMCLLVIGGQNYEAILEGNWAGVMSSYIGLPVFIAVWVIHALVTRDRLIPLEKVDVGGIDSATIKAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1U9</accession>
    <name>A0A2Z5R1U9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_2157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88456">
        <property type="protein sequence ID" value="BAV88456"/>
        <property type="gene ID" value="RA11412_2157"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2157"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016352582" evidence="2">
        <location>
            <begin position="38"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="607"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="669"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="733"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="795" mass="84812" checksum="1C2F93F589737F01" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1V7</accession>
    <name>A0A2Z5R1V7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86869">
        <property type="protein sequence ID" value="BAV86869"/>
        <property type="gene ID" value="RA11412_0570"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0570"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019277">
        <property type="entry name" value="DUF2304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10066">
        <property type="entry name" value="DUF2304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="119" mass="12968" checksum="5BFC9089D7611999" modified="2018-10-10" version="1">MVCLVLMQVRNQNMKEKYAALWLSVGGVMIVLALFPKLLDWFSSLVGIETPVNLLFLIAIVMLMGISLHLTLAISKLTDDARTIAEEVAIMRALQRQPEGAAGRGNTPASETNTPKSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R251</accession>
    <name>A0A2Z5R251_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_09400</name>
        <name evidence="3" type="ORF">RA11412_2499</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88798">
        <property type="protein sequence ID" value="BAV88798"/>
        <property type="gene ID" value="RA11412_2499"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2499"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340113" description="SURF1-like protein" evidence="2">
        <location>
            <begin position="43"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="324" mass="35790" checksum="CEEAAE7532A0D907" modified="2018-10-10" version="1">MWKLAFTPRWLGGLLLALVFVTGFVALSSWQFNASTSGQVHADTAKDTLRPYTDILKPHEPVTNITVDTVVRAKGSYVAGSSMLVAHRLNDGERGYWVLSEFIPEGTDTVTAQGSTKPRAIVVARAWVKGEGDAPAAIPAEPTGTVEVAGRVVNAQGPTEYKRQQQRILESASPAQLSNLWDTPLYDGVLALAAEVPEGQTIPVTEHHTIAENSTVIGQSQDVRPIRATQAVDDTSVNWLNIFYSLEWLIFAAFALYLWGRMLKDAAHRAAEPAEYTQYFEYEGEYFVDEATGRPYYWDPADKQYYFFDDAPSASSPGEPHTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2F3</accession>
    <name>A0A2Z5R2F3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell shape determination protein CcmA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09485</name>
        <name evidence="4" type="ORF">NCTC10207_01696</name>
        <name evidence="2" type="ORF">RA11412_2483</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037234671.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88782">
        <property type="protein sequence ID" value="BAV88782"/>
        <property type="gene ID" value="RA11412_2483"/>
    </dbReference>
    <dbReference type="GeneID" id="32322494"/>
    <dbReference type="KEGG" id="raj:RA11412_2483"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI23731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="151" mass="17130" checksum="9E7B47E003A82334" modified="2018-10-10" version="1">MNIFAALDDDRKLRRFLFWYWLLVPFALFAWILLGAANSNMTFQQALNIPFFAVAFLNGCLTILLAGLFKLAGSENERTERVFTLYALAVQIVVGNLPGALACYLLLRATRDWDETEKFAPTYRWVLIAAMVFLGMVSLLVLAANIRLWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2G4</accession>
    <name>A0A2Z5R2G4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdate-binding domain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Molybdenum-pterin-binding protein II</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Molybdopterin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mopII</name>
        <name evidence="5" type="ORF">I6I94_09660</name>
        <name evidence="6" type="ORF">NCTC10207_01668</name>
        <name evidence="4" type="ORF">RA11412_2441</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037234731.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88740">
        <property type="protein sequence ID" value="BAV88740"/>
        <property type="gene ID" value="RA11412_2441"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2441"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00638">
        <property type="entry name" value="Mop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VEI23670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="70" mass="7117" checksum="DC08E082B5677749" modified="2018-10-10" version="1">MKLSARNQLAGTIVEITEGATNGIVKIEIAPGLIVSSSITNAAIEELGLQVGKPATAIIKASNVMVGVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Q3</accession>
    <name>A0A2Z5R2Q3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88892">
        <property type="protein sequence ID" value="BAV88892"/>
        <property type="gene ID" value="RA11412_2593"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2593"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="111" mass="11778" checksum="8A8BF38640B2021C" modified="2018-10-10" version="1">MSAPAAESYDLKKGQLFNLLLITFASTVGFWAWTIVGPLAKYYAKPEQMNLNPGTTSLLVAMPIFIGAVGRIPIGGLTDKYGGRIMMSLVLAVSTPLVLLVGLAGSMKSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Q9</accession>
    <name>A0A2Z5R2Q9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="8">Holo-ACP synthase</shortName>
            <ecNumber evidence="8">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">acpS</name>
        <name evidence="11" type="ORF">I6I94_09295</name>
        <name evidence="12" type="ORF">NCTC10207_01742</name>
        <name evidence="10" type="ORF">RA11412_2525</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888734.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88824">
        <property type="protein sequence ID" value="BAV88824"/>
        <property type="gene ID" value="RA11412_2525"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2525"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="9">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT88706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VEI23811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="147" mass="16125" checksum="1992E02C52D445D7" modified="2018-10-10" version="1">MIIGIGVDTVNIERFERIVTETPAFVRRVFTASERTRNLRSQAVRFAAKEALAKVLGAPAGLNWQDCEVASTESGQPYLVVSGTIAARARSLGINRLHLSLTHDEPVAVAIATAEYLNTSELEHLRRFNPESYRITVLAPEPPGETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2S7</accession>
    <name>A0A2Z5R2S7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal RNA large subunit methyltransferase N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_2545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88844">
        <property type="protein sequence ID" value="BAV88844"/>
        <property type="gene ID" value="RA11412_2545"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2545"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="143"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="251" mass="27547" checksum="C10824F4DC8D4642" modified="2018-10-10" version="1">MTETFAGCAAASTDSTSRSTKVPVEISSVRPEPGKIALKAPRRTKPPKHIADFDMAGRREFLKELGYQPFRASQLSKHYFERLVNDPAQMTDLPAQDRDEIVSRAMPQLLTPVRTLEADGGDTLKVVHRLFDGALIESVIMRYDNRVTMCISSQAGCGMNCPFCATGQQGLTRNLSTAEIVEQVVAGARYLKQMKGLDKADGGSEDTRPLRVSNIVFMGMGEALANYKSTMGAVHRLIDPAPRDWVSPRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Y7</accession>
    <name>A0A2Z5R2Y7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Undecaprenyl-phosphate galactosephosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_2522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88821">
        <property type="protein sequence ID" value="BAV88821"/>
        <property type="gene ID" value="RA11412_2522"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2522"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="55"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="247" mass="27758" checksum="8CCFB026C04873F9" modified="2018-10-10" version="1">MRQLGWKLADARISLIMAPATTDVAGPRMHIQPLNGLPLVHVSTPRITGASAFAKRSIDVVCSGLGLLLLSPLFAIVALVVKSDRGPVFFFQERVGIKGQPFKMVKFRSMRTDAEEIKKQLAAQNEGHGLLFKMANDPRVTPVGRFIRKYSIDELPQLWNVFKGDMSLVGPRPPLPEEVEKYEEMVYRRLLVKPGITGLWQVSGRSDLSWEESVRLDLYYVENWSLTTDFVILARTVRAVFAKDGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R300</accession>
    <name>A0A2Z5R300_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88924">
        <property type="protein sequence ID" value="BAV88924"/>
        <property type="gene ID" value="RA11412_2625"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2625"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016411041" evidence="1">
        <location>
            <begin position="26"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="134" mass="13879" checksum="C14DE55804B0B452" modified="2018-10-10" version="1">MPRIASRIAAITPSATLVVDSKAKALKADGQPVIGFGAGEPDFPTPAHIVEAARQALNDPKNFRYSPSAGLPELKQAIAEKTLRDSGVQVDPSQVLVTNGGKQAVYEAFATVIDTGDDVLYPPPTGPPTLSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R319</accession>
    <name>A0A2Z5R319_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87299">
        <property type="protein sequence ID" value="BAV87299"/>
        <property type="gene ID" value="RA11412_1000"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1000"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tex_N" evidence="2">
        <location>
            <begin position="69"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="211" mass="22254" checksum="EBB2FC4196BD189A" modified="2018-10-10" version="1">MSAQRPHPKPANSSNRDGDAAPRPAPHNPAGGQGTTPAPAPGNRSHPHSPQPRNGTPNTSGAGEEAESIAAELHLAPANVNAVIALLDSGASVPFIARYRKEATSGMSDTNLRALHTRLTQLRALNQRREAIRTALTERYTEGLSTRSPTSSCSLGFAHPAPKPSWKTSTPPTAVSASPKPSRHAPPGWTRSLKTCWRCPSPVCTILPLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R322</accession>
    <name>A0A2Z5R322_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87309">
        <property type="protein sequence ID" value="BAV87309"/>
        <property type="gene ID" value="RA11412_1010"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1010"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="48" mass="5275" checksum="0ED0DC73AC2AABC1" modified="2018-10-10" version="1">MLRGRGLLSWLGRVLHTLKGTASSGGVFAGRVSYMPLWRCAKLLLCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R361</accession>
    <name>A0A2Z5R361_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_08515</name>
        <name evidence="3" type="ORF">RA11412_2715</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89014">
        <property type="protein sequence ID" value="BAV89014"/>
        <property type="gene ID" value="RA11412_2715"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2715"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV89014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="259" mass="27375" checksum="67572CB10CB0A45E" modified="2018-10-10" version="1">MSSNLPDGTLKPAFAEQPETSARLRRPGLKDPKFIVGILLVLVSLVGTIAVIQLNNRSTQYYIAKNDIPIGEKISTDKLTPVEANLGSASQNYLTAEEVQKGDLTAVRLIPAGEVVSKNSASNNVRENRRLVTVKVDRGLATNLKAGDHVDIWASNSTLSVGSQPSSAQKKPQDDKNNGGSQGSSSADGRGNSEISDDSTPIAKDAEISNISVEENVLGSNGKATVQLWVASNSLYPVIQADSTNAKISLVPIALGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R371</accession>
    <name>A0A2Z5R371_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88951">
        <property type="protein sequence ID" value="BAV88951"/>
        <property type="gene ID" value="RA11412_2652"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2652"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="233" mass="26757" checksum="BB8E8A9B64DF447F" modified="2018-10-10" version="1">MLRIAHTRISDPTHELYLVPPIFTPNHDADFVGYLHSPDADQWAPDIEFKYFARGGELMIRARSRLHWDDPAVSRFALASIDAQLNLHWEQRDENPRRRDYTEAVIGALHKSMRHPARTIADGQCVAVRSPDGEASSYHLREGNDIIRVINITEYSNSQTRNAKAGYYGRVLSYFEEDTALAWHAAEQDARCWPYGMNPLFDTPLTGSDIPEWHVQPILRHLPDSSIRRQRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R373</accession>
    <name>A0A2Z5R373_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87389">
        <property type="protein sequence ID" value="BAV87389"/>
        <property type="gene ID" value="RA11412_1090"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1090"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="135" mass="15377" checksum="B5C2AADB6B1BA087" modified="2018-10-10" version="1">MDSSYKSSEETDFAWRVQLAGIPAAFTHGPLLHYILRDKPKRIFHQQRAYQKYKVLLWVHYRQYGMRGPSTKASILEILRQVPKLINPATRFRAAYLAGGNLGALEGILQYRVLKRIPKPLRLDTAPVSTVASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R381</accession>
    <name>A0A2Z5R381_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_2672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88971">
        <property type="protein sequence ID" value="BAV88971"/>
        <property type="gene ID" value="RA11412_2672"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2672"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="195" mass="21121" checksum="A61CE1FA82857FCA" modified="2018-10-10" version="1">MVVMTETVATNGAPRAERAPRGCAHTGPLPADADTTPQLLEEVWSASLRSKGRRVTKQRLAVLRAVQSHPHSNAEEIVTAVRQELPSITVQSVYVILTDLTDIDLLRKFEPPGTPGLYETRTGDNHHHAFCIRCGKVQDVDCAIGSAPCLTPSDFHGMALISADVLYQGICADCQTEEETYLAAAQKQAAESISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3N7</accession>
    <name>A0A2Z5R3N7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_1400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87699">
        <property type="protein sequence ID" value="BAV87699"/>
        <property type="gene ID" value="RA11412_1400"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1400"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="116" mass="12987" checksum="A6F13DF17378914B" modified="2018-10-10" version="1">MGWYRRRWVLNTAVVLGILLQVAVLVVGVEVGGNRNWIVLGPVQLQPSELSKPILILWMALMLARQGTFRRTAGGLFSPRFLAFCRWWALSCWAETWVPLSSTVSSLWDAVAGGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3R9</accession>
    <name>A0A2Z5R3R9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87889">
        <property type="protein sequence ID" value="BAV87889"/>
        <property type="gene ID" value="RA11412_1590"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1590"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="46" mass="5199" checksum="16A778B66989FBF6" modified="2018-10-10" version="1">MSKNLELLRQGSSPRMRGTRYGEEGREAGRGLIPTYAGNTRSRAWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R402</accession>
    <name>A0A2Z5R402_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">RA11412_1870</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88169">
        <property type="protein sequence ID" value="BAV88169"/>
        <property type="gene ID" value="RA11412_1870"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1870"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="123"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="244"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="255"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="BAV88169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="396" mass="42346" checksum="B38D646EA893A9C3" modified="2018-10-10" version="1">MRLFTSESVTEGHPDKICDQISDAILDGIIAQDPVANVAVETMVTTGQVHVAGEVTTSSYVEIPAIVRETILGIGYDSSTRGFDGEFCGVSVSIGEQSPDINAGVYESLEARTGVAVDDYDRQGAGDQGIMFGYASNETNVFMPAPVWLAHRLSEKLTKVRKNGTLVNLRPDGKTQVTLGYDGNNTPVSVDTIVVSTQHTADYDLADLAADVKNQVIVPVLSGLELDTSNTKFIINPAGRFVQGGPVGDAGLTGRKIIVDTYGGSARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLADRAEVQVAYAIGQASPVGLYVETFGTEKVDPAKIEKAIREVFDLRPLAIINDLDLRRPIYKKTAAHGHFGRTEPEFTWERLDRVEALRSAVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4N5</accession>
    <name>A0A2Z5R4N5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88699">
        <property type="protein sequence ID" value="BAV88699"/>
        <property type="gene ID" value="RA11412_2400"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2400"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102682">
        <property type="term" value="F:N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="160" mass="17583" checksum="0591C0505C450667" modified="2018-10-10" version="1">MERAQQMGRACAERGIGVVYGGGSTGLMGTVAGAALDAGGKVYGVVTHQLVEWEGVYPGQTTLDIVDTMHQRKIAMINKADAFVALPGGPGTLEEFFEVFSWQFLKIHDKPVALMNVNGYWTKLIEAMEYMSTTELLKPEYLQRLIVVETPEELMKVLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4P2</accession>
    <name>A0A2Z5R4P2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiol peroxidase</fullName>
            <shortName evidence="2">Tpx</shortName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peroxiredoxin tpx</fullName>
            <shortName evidence="2">Prx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">tpx</name>
        <name evidence="5" type="ORF">I6I94_09795</name>
        <name evidence="4" type="ORF">RA11412_2410</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxiredoxin family. Tpx subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88709">
        <property type="protein sequence ID" value="BAV88709"/>
        <property type="gene ID" value="RA11412_2410"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2410"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03014">
        <property type="entry name" value="PRX_Atyp2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00269">
        <property type="entry name" value="Tpx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002065">
        <property type="entry name" value="TPX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018219">
        <property type="entry name" value="Tpx_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01265">
        <property type="entry name" value="TPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="166" mass="17365" checksum="D49C289D69B48C74" modified="2018-10-10" version="1">MAKITFHEETPVNTIGELPAVGTKAPAFEVLGAELNTITGTDFAGKNIILNIFPSVDTGVCATSVRTFNKDAAALDNTVVLCVSNDLPFAIGRFCAAEGIENVIATSAFRSSFGQDFGVTMTDGPLEALLARAVVVVNPAGEVVYTELVPEITNEPNYEAALAAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4T5</accession>
    <name>A0A2Z5R4T5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rpsK</name>
        <name evidence="10" type="ORF">I6I94_09235</name>
        <name evidence="11" type="ORF">NCTC10207_01754</name>
        <name evidence="9" type="ORF">RA11412_2540</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888779.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88839">
        <property type="protein sequence ID" value="BAV88839"/>
        <property type="gene ID" value="RA11412_2540"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2540"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT88696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VEI23826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="134" mass="14158" checksum="2984AEDBA05FADFF" modified="2018-10-10" version="1">MPPKTRAAAARKTRRKVSKNIVAGQAHIKSTFNNTIVSITDPTGAVISWSSAGDMGFKGSRKSTPYAAQLAAEAAANRAKEHGVRKVDVFVKGPGSGRETAIRSLQAAGLEVGSIQDVTPVAHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4W1</accession>
    <name>A0A2Z5R4W1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">rplK</name>
        <name evidence="12" type="ORF">I6I94_08890</name>
        <name evidence="13" type="ORF">NCTC10207_01824</name>
        <name evidence="11" type="ORF">RA11412_2620</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887755.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88919">
        <property type="protein sequence ID" value="BAV88919"/>
        <property type="gene ID" value="RA11412_2620"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2620"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="10">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="9">
        <location>
            <begin position="73"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV88919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT88628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VEI23957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="142" mass="14773" checksum="E0561B5467EE42EF" modified="2018-10-10" version="1">MAPKKKVTGLIKLQIQAGAANPAPPVGPALGSHGVNIMEFCKAYNAATESQRGNVIPVEITVYEDRSFTFITKTPPAAEMIKKAAGVAKGSATPHTVKVGSITEAQAREIAETKMPDLNANDLDAATKIVAGTARSMGITVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVA9</accession>
    <name>A0A2Z5QVA9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86323">
        <property type="protein sequence ID" value="BAV86323"/>
        <property type="gene ID" value="RA11412_0024"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0024"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016306847" evidence="1">
        <location>
            <begin position="22"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="190"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="378" mass="43037" checksum="899EB5325FFC01F3" modified="2018-10-10" version="1">MARKIFLLAGAAGAGKSTWIAAHPELADLTHSWDAERRKCGYITYTLDNQPALALSQNTSAESKAIRRVNDCVEENMRHGNTVFIDNMNVLLRNMKTFLEFARKYCYTAYLVDFQGELTLDELYARNRAREYTKRVPEEVIETAYNNHRELRENWRSTLKNYRDVVAGYIAPDQVFAELFTPVRALDNYHKVVVVGDIQGMGSELEKLIDTLSPETGLSDENICWIFAGDLFDRGQNPEKVFDILEPALGTLPNVHLVMGNHERSIMHTIRGVRRYRDARETLDALAAHGVYNSRVIAMLNTAVNMMPFTLGQERYFVTHAGVAPQLFADSHRTLEGVGRGTSRGCMQMKRSIWVLIRTRRRGRVKPSTRATKTRSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVC6</accession>
    <name>A0A2Z5QVC6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pseudouridylate synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ribosomal large subunit pseudouridine synthase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_07960</name>
        <name evidence="3" type="ORF">RA11412_0049</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86348">
        <property type="protein sequence ID" value="BAV86348"/>
        <property type="gene ID" value="RA11412_0049"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0049"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="2">
        <location>
            <begin position="119"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="366" mass="40562" checksum="2C6F35F2532FD491" modified="2018-10-10" version="1">MPRRVTRDTKTPPLPQRAGIDPVAFTLPNDPGAALDIAGSAHPNQPVRTVADFLVARFYPHNPRIITDRLERGEIRTDNGRILTGDSPYVPGLTIWYYRELPEEPQLPDDLPVLYEDEHVLAVDKPHFLPTTPRGAFVAQTALTKLRVREGNPLLVPVHRLDRATAGVLLFAKTVPARGLFQTMFARREVFKEYLAVARPIPDPQARAAALSGELTVRTRIEKIRGKLQVRQWDQPSCERELLNPNATTGVRILTVFDAPGPHHTANTPQHTGAIAHPAPGCPVTGGQLALYRLRPHTGKTHQLRAHLHLLGAPIAGDVLYPKVLPPADAPELPLQLVAHRLEFEHPVTGERVRLRSMRKLALLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVE7</accession>
    <name>A0A2Z5QVE7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylaminoimidazolesuccinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0069</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86368">
        <property type="protein sequence ID" value="BAV86368"/>
        <property type="gene ID" value="RA11412_0069"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0069"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="8">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="201" mass="22574" checksum="629DE1FB758426E5" modified="2018-10-10" version="1">MICKSLNMFPVECIARGYLTGSGLETYRENGTIAGIELPAGLVNGSRLQPPIFTPTGKAEVGEHDEMVTRQELWEEVGEAVAERLEELTLYIYTTAEKIAREQGIILADTKVEFGTDSYRGEITLGDELLTPDSSRFWDASEYEPGKSQPSFDKQYVRDWLRSPEAGWDGSDNVPHLPEAVVEKTRARYIEAYERLTGTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVE8</accession>
    <name>A0A2Z5QVE8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86365">
        <property type="protein sequence ID" value="BAV86365"/>
        <property type="gene ID" value="RA11412_0066"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0066"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="69" mass="7721" checksum="8A4187CC18D3875C" modified="2018-10-10" version="1">MRRVLNNYYSLRGQAQTRWQGHRRVYRVLGGVFTHPTPKISICETWGGGFGLLPGAAVPRQGLFGGTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVF5</accession>
    <name>A0A2Z5QVF5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86373">
        <property type="protein sequence ID" value="BAV86373"/>
        <property type="gene ID" value="RA11412_0074"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0074"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="78" mass="8299" checksum="A316613207BC0FC0" modified="2018-10-10" version="1">MAIRRKVSEADGAAALATVRGVFEAGTPLTGGQNREEMERLFASLPRGVRATAVRYSLEELGTLAPGNSVEVRVPRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVH0</accession>
    <name>A0A2Z5QVH0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAGPA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86380">
        <property type="protein sequence ID" value="BAV86380"/>
        <property type="gene ID" value="RA11412_0081"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0081"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAGPA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="126" mass="13314" checksum="6C76FD1B8363317A" modified="2018-10-10" version="1">MLNTLSFGPALVKNSEVMSGIDQVEVDTNFGNHSIQGNQPRTGVGVLGNNHLLFMVVDGRSDGYSRGVTMPEFAQMFKEHGCETAYNLDGGGSSVMVFNGKLVNKPLGGSKERGTSDILYIAGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVJ3</accession>
    <name>A0A2Z5QVJ3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6318 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86413">
        <property type="protein sequence ID" value="BAV86413"/>
        <property type="gene ID" value="RA11412_0114"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0114"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046281">
        <property type="entry name" value="DUF6318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19843">
        <property type="entry name" value="DUF6318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6318" evidence="2">
        <location>
            <begin position="7"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="185" mass="20684" checksum="E542C133B68919D9" modified="2018-10-10" version="1">MDSSGPRQEYATREKPQQNTYPPKKPSTINDRTERGLYSSISFAVTSLDYALQTGNARYLEQSAIVESEQLYFKKSTNLIDTRDGKYWTAAGSILQYTLVGSHPVASSGGEYVWAYNLVLLNGDFYVKDGKVHEVTKETYSGKGDWGKRYHTNGEIRAKYVNGQWQISGLLSNDLPLVPPENGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVS7</accession>
    <name>A0A2Z5QVS7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86505">
        <property type="protein sequence ID" value="BAV86505"/>
        <property type="gene ID" value="RA11412_0206"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0206"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="324" mass="35050" checksum="1EFB97E6EAA86C56" modified="2018-10-10" version="1">MRTPVNLRVYGFAMRAPHIKHSAKHALLVNMLDAKKSLFDNDGNPRPALTNALDTVLRLQRPLALSMVKKLRAAHPHETPEQILRRLDRQYLRDVTAIGGVTGASAFVPGIGTVTSMGLSALAVGGYLERTALYAQAVAELHGVHVKDPDLARSMVMAIMLGEEGSQLMNTVLLQTGKATGVSGRWGMLLGGKSSGKMFSVERAIRNMFIKRFLTRQTGAFLGRALPFGVGAVVGGGANYGLGKDVVKNTREAFGDAPPFFPLELMVEPRAPKFDDANEGKGPSKARRALTGRFKRNKADTKNHDVHSHGLQNPGAQHRKTMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVW2</accession>
    <name>A0A2Z5QVW2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">upp</name>
        <name evidence="13" type="ORF">I6I94_07310</name>
        <name evidence="14" type="ORF">NCTC10207_02167</name>
        <name evidence="12" type="ORF">RA11412_0221</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 11"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887073.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86520">
        <property type="protein sequence ID" value="BAV86520"/>
        <property type="gene ID" value="RA11412_0221"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0221"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="11">
        <location>
            <begin position="130"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="11">
        <location>
            <begin position="201"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV86520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT88347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VEI24610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="212" mass="23257" checksum="FAEC915D8D8C20D7" modified="2018-10-10" version="1">MRIKILDHPLVAHKISVLRDKNTPSPTFRQLVDELVTLLAYEATREIRVEQREIETPVARTVGTMIASPKPLVVPILRAGLGMLEGMTRLVPTAEVGFLGMARNEQTLDIVTYAERLPEDLTGRQVYLLDPMLATGGTLIEAIKFLRQRGAESITCVCLIAAPEGIAALEKGVEGLRNVDLFLAARDERLNEKAYIVPGLGDAGDRLYGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW36</accession>
    <name>A0A2Z5QW36_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86601">
        <property type="protein sequence ID" value="BAV86601"/>
        <property type="gene ID" value="RA11412_0302"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0302"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="432" mass="45313" checksum="1F9A6B42ACBB3A20" modified="2018-10-10" version="1">MSEKLNGPSADEPERGGAQGKNTHHDDSQRAGSAGAGADGAGGRGAAGSKPGSAPLGSSGSSGLQIGARPEGVPGANLTAEEIARRASGRGTWHRRASKPVSYWMFGIIAALLAHRFIPNGGWLIVHMVTLGLITNSILIWSQHFTEALMKIKIPDEARGVQVTRIFTLNAGIVVLMLGMVFQEQLPTLYILTLAGASVVGAMVAWHGVALLKQVKQALPSRFGATIRFYIAAAFMLPFGAALGAMTAFPGLEKTLHAQFLLAHEAVNVLGFVGVTVVGTLITFWPTMLRTKMVENALGISVRALQLMIAGVLVTALSAIFGGVPGARFAAGAGLLAYCVGLLMVAVVMVRTMRTKRPGEFPPMSVGRGSSGWCWGCSPPRLWCSAPRSLSLICAPSPPCLWRGSCCRCCWGYELPAAAAYGRRPGGGARLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW77</accession>
    <name>A0A2Z5QW77_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell filamentation protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Fic family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_06715</name>
        <name evidence="3" type="ORF">RA11412_0342</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86641">
        <property type="protein sequence ID" value="BAV86641"/>
        <property type="gene ID" value="RA11412_0342"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0342"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="2">
        <location>
            <begin position="69"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="328" mass="37488" checksum="392926FB0FAF822E" modified="2018-10-10" version="1">MEQRWLQEQAASPEWYAYYIPFTYTLRNKFTTPEHPYGEPNPEKLRSLEEQVTKVRMRNLYDNPIQGNFDYNHMKAVHHAIFQDVYDWAGQERTAPTNGPMVKLGHAYYPAGPNLTAAAHAQYDLLARKNLLRGLDQNTFVTGLAESWGEINVVHSFREGNTRSQFVFFSQLAQQAGYHIDTAAFAPGNPLRDEFVQARFYSQDTGRNDRLAAVLGKAITPISPSVSAQGHEVPLQREVGLSRGVSLNNAGDPNLRRTDDAPTLGSSEAPKNTYNRYQLRSKLDDVKNTAPSHQQNRSQNTQQRQEPQKYRQPHPRRERNDRHPRMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW81</accession>
    <name>A0A2Z5QW81_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_06710</name>
        <name evidence="1" type="ORF">RA11412_0343</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_052029801.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86642">
        <property type="protein sequence ID" value="BAV86642"/>
        <property type="gene ID" value="RA11412_0343"/>
    </dbReference>
    <dbReference type="GeneID" id="32322314"/>
    <dbReference type="KEGG" id="raj:RA11412_0343"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="158" mass="17974" checksum="56D249C759D40326" modified="2018-10-10" version="1">MELQELVEKARHTKVRKKLLDLEIYRAAKTLADAGATPHDFAHGLGISKYELPDMLKKAERVEPIRAGFSSGSPYEICQRYYVGELTRAQAIDELVRWEYKPQAKGEEWDPWGMEGGAPRVRGSWDDLDTAETHELIDYDLTLEVSRTRAALRRAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW97</accession>
    <name>A0A2Z5QW97_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Phage lysin N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06540</name>
        <name evidence="2" type="ORF">RA11412_0386</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86685">
        <property type="protein sequence ID" value="BAV86685"/>
        <property type="gene ID" value="RA11412_0386"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0386"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033776634" evidence="1">
        <location>
            <begin position="42"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="158" mass="16396" checksum="7E2DB207A04B2FEF" modified="2018-10-10" version="1">MNLENTGLSRRKLLRTAAIGVPAAGAVAMGATLIAAPASNAAMIAADGYWGTETTRMLQTLFKLDVVDGIVSSQPASRASANPGLAGGWDWVPDASANGSQTIRALQGMLKVTQDGLIGPGTISALQARYKLTQDGVLSAESPTIKRLQAELNRVAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWB6</accession>
    <name>A0A2Z5QWB6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Possible integral membrane sulfate transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">SulP family inorganic anion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_06560</name>
        <name evidence="7" type="ORF">RA11412_0382</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86681">
        <property type="protein sequence ID" value="BAV86681"/>
        <property type="gene ID" value="RA11412_0382"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0382"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="6">
        <location>
            <begin position="15"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV86681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="523" mass="55297" checksum="475FBCBE41653FE7" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWC5</accession>
    <name>A0A2Z5QWC5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin</fullName>
            <ecNumber evidence="1">1.16.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bfrB</name>
        <name evidence="4" type="ORF">I6I94_06425</name>
        <name evidence="5" type="ORF">NCTC10207_02367</name>
        <name evidence="3" type="ORF">RA11412_0416</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-storage protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide</text>
            <dbReference type="Rhea" id="RHEA:11972"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:78619"/>
            <dbReference type="EC" id="1.16.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferritin family. Prokaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.2" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI25011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006886973.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86715">
        <property type="protein sequence ID" value="BAV86715"/>
        <property type="gene ID" value="RA11412_0416"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0416"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041719">
        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT90120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI25011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="174" mass="19846" checksum="478B59DE9FF11865" modified="2018-10-10" version="1">MTKSFYELLTEQIGHEFAASHQYLAMAIWLDGEDLPQLARYFYRQSLEERDHALMMVQYQLDRGHKVQIPAIPAVQNDFADVQEIVDMSLAQEKEVTTQIEAIFAAARAETYPLGEQFMLWFLKEQVEEVASMETLVTIVKRANGNLFDIENYVARELDENHGEDDSAPAVAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWD8</accession>
    <name>A0A2Z5QWD8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86663">
        <property type="protein sequence ID" value="BAV86663"/>
        <property type="gene ID" value="RA11412_0364"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0364"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="169" mass="19243" checksum="0201A5912DD40F2F" modified="2018-10-10" version="1">MELQDTVAKAYKLRVEKELIELAELRMVKALADAGAKHNQFARGLGISKYELPDMLKKAERVEPIRAGFSSGSPYEICQRYYVGELTRAQAIDELVRWEYKPQAKGEEWDPWGMEGGAPRVRGSWDDMNTAKTHKLIDYDFYTEVGDKIDAKAQATPKDKPLDRAPNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWE4</accession>
    <name>A0A2Z5QWE4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADA regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86706">
        <property type="protein sequence ID" value="BAV86706"/>
        <property type="gene ID" value="RA11412_0407"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0407"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="74" mass="7800" checksum="A9F67B761B28B51D" modified="2018-10-10" version="1">MSITDRSAASTDPIEQTVQFGRIAAAIEYLYDHAADHPTLAQVSQAVHVNPNICSGSSSSGRGEPQENAAAYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWF3</accession>
    <name>A0A2Z5QWF3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">L-O-lysylphosphatidylglycerol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RA11412_0422</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86721">
        <property type="protein sequence ID" value="BAV86721"/>
        <property type="gene ID" value="RA11412_0422"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0422"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031553">
        <property type="entry name" value="tRNA-synt_2_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16995">
        <property type="entry name" value="tRNA-synt_2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="12">
        <location>
            <begin position="777"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV86721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="997" mass="110698" checksum="043F09F5FFDA5AA9" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWI1</accession>
    <name>A0A2Z5QWI1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gyrA</name>
        <name evidence="11" type="ORF">RA11412_0486</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86785">
        <property type="protein sequence ID" value="BAV86785"/>
        <property type="gene ID" value="RA11412_0486"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0486"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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            <begin position="35"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="833"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="554"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="854"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV86785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="880" mass="97491" checksum="B7B68165351CCC39" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWK9</accession>
    <name>A0A2Z5QWK9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Shikimate 5-dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Shikimate 5-dehydrogenase I gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06050</name>
        <name evidence="2" type="ORF">RA11412_0499</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86798">
        <property type="protein sequence ID" value="BAV86798"/>
        <property type="gene ID" value="RA11412_0499"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0499"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
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        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="1">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="271" mass="28496" checksum="C400ACCA7162C06E" modified="2018-10-10" version="1">MRPALNKNTTVCISLSGRPSNHGIKFHNYLYEKHGLDYLYKAMTTTDIEGAIAGVRALGIRGCSISMPFKQAVIPLMDEVDHSAQVIGAVNTIVNTDGYLHAYNTDVIAVASLLKSHAVDPKLPFLLRGSGGMAAAVAGAFYDAGFRAGTIIARNEAAGTALAHRYGYAWAPEPGDLTAPVIVNVTPIGMSGGAESEQLAYPQPTIEAASVVFDVVAMPVETPLIRAARAAGREVITGGEVIALQAAEQFRLYTGVTLSPDDIAQAEAQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWU5</accession>
    <name>A0A2Z5QWU5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavodoxin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86898">
        <property type="protein sequence ID" value="BAV86898"/>
        <property type="gene ID" value="RA11412_0599"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0599"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="1">
        <location>
            <begin position="50"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="242" mass="26944" checksum="85EF1F7D65DB2AEE" modified="2018-10-10" version="1">MLGRRAHPVIEAPSGVLRLGRLRNGSFFAVRIGRLFSEYRFERLRSEHVNILLLDGGKAFGHSAGRLNHTLHQTARSALQAQGHHTRETVIDEGYDLPQEVDKFLWMDAVIWQMPGWWMGPPWTVKKYVDEVFTAGAGMLFANDGRSSASPTEGYGTGGLLTGRQHMLSLTWNAPLEAFTRAGDFFGGAGVDAVYLPFHKANEFIGTSQLPTFICNDVIKNPQVEQYIVNYIAHLEKVFGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX20</accession>
    <name>A0A2Z5QX20_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86764">
        <property type="protein sequence ID" value="BAV86764"/>
        <property type="gene ID" value="RA11412_0465"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0465"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="99" mass="10949" checksum="833605FB11C0DA72" modified="2018-10-10" version="1">MSQQIPVGTVLGGRYEITAQIIVTAETDMILDGMDQILSRKVSVVVASPARSNLLENNSRVLNESNPYSFQMLDMGITPEGSKYLITSYTAPQCCWMRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX45</accession>
    <name>A0A2Z5QX45_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporting ATPase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_0661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86960">
        <property type="protein sequence ID" value="BAV86960"/>
        <property type="gene ID" value="RA11412_0661"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0661"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="624" mass="65543" checksum="22E15FCA66EB73A2" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX64</accession>
    <name>A0A2Z5QX64_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Low-affinity inorganic phosphate transporter 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Probable low-affinity inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pitA_2</name>
        <name evidence="9" type="ORF">NCTC10207_00216</name>
        <name evidence="8" type="ORF">RA11412_0736</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">NCTC10207</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87035">
        <property type="protein sequence ID" value="BAV87035"/>
        <property type="gene ID" value="RA11412_0736"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0736"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033777408" evidence="7">
        <location>
            <begin position="25"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VEI22150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <sequence length="343" mass="36205" checksum="7920319AA809F7D6" modified="2018-10-10" version="1">MPTLLYLLCVAAFCAAIFVTGVHNASNAIAVPVRTRAMTPVAALVVSALFNGAGVILAYMLIKEYEASWLVVPGGTPTLLGIVCALTTTAAWGTITWAMRMPSSATHALIGALAGVAWYAHTDGFENYGFVHTIFTTALAPLLLLPPLTFLLSWVLVFPFYRLALRTAPHRVNSTSREVLAVSTAGISLLHGLQVGQRYLLLLLLSGVLAPFTSAVSFDKAPATLMIVCAVLVAAILAAGTLTGGWRIGYTFTHRMVRLDPLRGAIAQGTTAAVLAAGQFVLQLPFSSSHLAVASALGAGVNQRHASVSARVVRQILLTWVITFPACFLLAVALMSVTGLFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX74</accession>
    <name>A0A2Z5QX74_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="13">FBP aldolase</shortName>
            <ecNumber evidence="5 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RA11412_0634</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 13"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86933">
        <property type="protein sequence ID" value="BAV86933"/>
        <property type="gene ID" value="RA11412_0634"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0634"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="PTHR30559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="11">
        <location>
            <begin position="239"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="11">
        <location>
            <begin position="260"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV86933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="323" mass="34548" checksum="3535999B36F6940D" modified="2018-10-10" version="1">MLENAKAKGFAYPAVNVTSSQTLNAAIRGFAEAGSDGIVQASTGGAAYWSGASKKDMVVGSLAFAAYAREVAKQYDVNIALHTDHCPKDKLDGFVLPLLAESEKAVARGEDPIFNSHMWDGSAIDLDENLKIAAELLERTNKAKIVLEVEIGAVGGEEDGVEGAIDDTLYTTVDDAVKTVEALGLGEKGRYIAALTFGNVHGVYKPGNVHLRPELLKQIQDEIGAKYGKEKPFSLVFHGGSGSTAQEIADAVSYGVIKMNIDTDTQYAFTRPVAGHMFSNYDGVLKVDGEVGNKKTYDPACGALRLKRAWQLAWSRLASSSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX83</accession>
    <name>A0A2Z5QX83_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05510</name>
        <name evidence="2" type="ORF">RA11412_0644</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86943">
        <property type="protein sequence ID" value="BAV86943"/>
        <property type="gene ID" value="RA11412_0644"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0644"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="402" mass="42245" checksum="62B6BB08E8D7C11B" modified="2018-10-10" version="1">MARTPEAITPSSWRKVIAIATLASVIVSIVILAFTWPTKAMETKNLPVSIAGPEAAVSQFEQGLKDRGVETFEFKQASSREDAERQIKERETYGAIVFTEGAAPEVMTAPAANASANQMLTGVAQQMNAQVQQQATAAKTQALQQAAQAGGQQGAIATQQLEQLKTEQEKLQQAQVKTTAVVPLGEGDPNGMGLAVAAFPLVMGGIIGGVLSISLVKGTVRRFATAGLYGILGGLFMTLILGTWFGFVPGDFGALWATFGMTVFATASFMIGMSALFADAVGIGLGAVISMFIGNPLSGANMPRQFIPAPWGALGQLMVPGASNTLLRNIAYFPDASNSLPWAVLLGWAGFGLLAGVIGWAWKERRATHMSAEDDTASVRAKTEANADVPDNVEIPWKAANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXA9</accession>
    <name>A0A2Z5QXA9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-alanine-DL-glutamate epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_04975</name>
        <name evidence="1" type="ORF">RA11412_0763</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87062">
        <property type="protein sequence ID" value="BAV87062"/>
        <property type="gene ID" value="RA11412_0763"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0763"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="205" mass="22464" checksum="82E6EA69A3B19CE8" modified="2018-10-10" version="1">MAVSREQVFEVLQRVHQALEHGLPGWSVRPNITGTGAVGLYLDGPELPLMGVNLAGEPVARHLCGTVQSADRGLPGELDQVRYQYILGVSVTERDEEYPELTDLPKTGEPSWVDALRVLERQVIAEARDEFFISRGGYVPGRRALGKRRVALRREFFPGKPWLGLGTIDWCAGVRSTPVYAGELDALATAAVRLASTWDAALRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXF4</accession>
    <name>A0A2Z5QXF4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87016">
        <property type="protein sequence ID" value="BAV87016"/>
        <property type="gene ID" value="RA11412_0717"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0717"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="5224" checksum="83F41949E4E1E4A2" modified="2018-10-10" version="1">MRWINRADRSERAAQREAEKDAQLWYEQVKSSRGSVNPFTDDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXH7</accession>
    <name>A0A2Z5QXH7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86934">
        <property type="protein sequence ID" value="BAV86934"/>
        <property type="gene ID" value="RA11412_0635"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0635"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="286" mass="30648" checksum="607E18F16B56679A" modified="2018-10-10" version="1">MSAGVASTGGASETSIVPPKTKAEAYTLAKTARTFKVVFIGVRFFFLLLPLLALLVATVSGVVFPAPTVFAYPILLLLSLGQLDKGRVAVNVAANILTLLSLPFLWGITMSLYKIFMTPGIMLCAFELFCAVYSLAQAPKISKGYIQLGEGGRHLYEKYLTAEDLPREMSLSNITPPAHPDTPEKPVENPEGGAKSSSNTVPESTESTSTDAPTETTVPAVTQSDEPETEIPETHDKEPASSDSGEHNSLLPGIPVVSEHLVQQAQSSQLRPQSHPSSKQHKTHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXJ3</accession>
    <name>A0A2Z5QXJ3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87168">
        <property type="protein sequence ID" value="BAV87168"/>
        <property type="gene ID" value="RA11412_0869"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0869"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="169" mass="18434" checksum="25FE52E90118EC04" modified="2018-10-10" version="1">MTNGTGGAWEFIDLKIAQAREDRVRYAVPTVQLYAGHSGENTLADVNDLFAGFMLLPRVGVGKNVHEVSQVRTKFTLTSRARGSLPLILDLKERTMTITDVGIRSGANVIESGPVVKAMFELFAHYAPFTVADYLNLTGATVVGEDEEADIVLQPTVASLSQLYRYKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXL1</accession>
    <name>A0A2Z5QXL1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DedA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87050">
        <property type="protein sequence ID" value="BAV87050"/>
        <property type="gene ID" value="RA11412_0751"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0751"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="112" mass="12228" checksum="4A018FDAC1256CB6" modified="2018-10-10" version="1">MSTKNLHAAEEFFAKRGGVALVLGRFVPIVRTFVSLAAGISSYPRRKFNLWNILGAVLWIGLIGTAGVLLGGIEFVHKNIELLAVIIVLVSVVPVAIEYIRGRKKEQKALSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXM5</accession>
    <name>A0A2Z5QXM5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_04395</name>
        <name evidence="7" type="ORF">RA11412_0908</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87207">
        <property type="protein sequence ID" value="BAV87207"/>
        <property type="gene ID" value="RA11412_0908"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0908"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="7"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="398" mass="41058" checksum="D4E2978EBA79735C" modified="2018-10-10" version="1">MNRRHWCLAAVLIGSASATLMQNFITVSLPTIASELAGHSTVGWVVGAYMLASTAVLLNSGRWADRQGPRKVYVVGTLLYAAATVLTSQSQSMVQLIMFRVIQGLGAGIIVPASMAAVTRYWRDKRLGRIIGLLGSMQVVATLIGAPLGGWLTSVLGWRVAFASPALLSITALALSLSLPGSRLPSEPAEARSLLSVLAEPVLVRGLISTAGLSSLAFGAAVYLPMSMAHTLQMDAATLGWLVLPLVAGSGIGSAIGGLRAHHARTEVIGWLTATIGVLTCLVPHIWSLTVGGALVGIGVGIGMPAIFVRLQGAIGGGNEAVTSGFVQFARNAGGALGVPLYGIGLMLPVVLSVSLLLTFSFMSAAAIGGLILCWAGIIGVSACNPVHEPLRKDRVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXR4</accession>
    <name>A0A2Z5QXR4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87133">
        <property type="protein sequence ID" value="BAV87133"/>
        <property type="gene ID" value="RA11412_0834"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0834"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="4849" checksum="A18CC841F4366B81" modified="2018-10-10" version="1">MPEYTGATNVKYAQQRSNSGLACQTSNNPVLKAVQNNLKFYSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXS3</accession>
    <name>A0A2Z5QXS3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87143">
        <property type="protein sequence ID" value="BAV87143"/>
        <property type="gene ID" value="RA11412_0844"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0844"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="47" mass="5134" checksum="9344D0FFC73F8862" modified="2018-10-10" version="1">MSLCHISAGNRNSDVFLITYLPVGYAMVWSRRWSIAGMKYAGGAPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXU2</accession>
    <name>A0A2Z5QXU2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="5">FGAR amidotransferase II</shortName>
            <shortName evidence="5">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purL</name>
        <name evidence="9" type="ORF">RA11412_0847</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87146">
        <property type="protein sequence ID" value="BAV87146"/>
        <property type="gene ID" value="RA11412_0847"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0847"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="8">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="103"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="218"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="325" mass="34345" checksum="04C23655E06A129F" modified="2018-10-10" version="1">MSEKQFNLDTVEHAAETPDTELPWAELGLKENEFEDIKKILGRRPTAAELAMYSVMWSEHCSYKSSKVHLKQFGAKVTDEMKKDLMVGIGENAGVTDIGDGWAVTFKIESHNHPSYVEPYQGAATGVGGIVRDIISMGARPIAVMDPLRFGAIDHPDTARVVGGVVAGIGGYGNSLGLPNIGGETEFDACYQANPLVNALAVGIMRHEDIRLANASGVGNQVVLFGARTGGDGIGGASVLASESFDDTKPSKRPAVQVGDPFAEKVLIECCLELFKGSVVEGIQDLGAAGISCATSELASNGEGGMHVDLTKVLLRDPTLTPAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY22</accession>
    <name>A0A2Z5QY22_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mut-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87358">
        <property type="protein sequence ID" value="BAV87358"/>
        <property type="gene ID" value="RA11412_1059"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1059"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="132" mass="14668" checksum="B1ABCA7183AFFB42" modified="2018-10-10" version="1">MLLVRRSDNGAWTPVTGIVDPGENPALTCLREAHEEAGVKIEVLALAQLKADPAMRFGNGDRCQFLDHTFLCRWVAGDARVNDDESTQVRWADMTDPTERAMLSERMLDRIDAALGYDGHCRFGYESVSPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY27</accession>
    <name>A0A2Z5QY27_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="6" type="ORF">I6I94_04205</name>
        <name evidence="5" type="ORF">RA11412_0962</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87261">
        <property type="protein sequence ID" value="BAV87261"/>
        <property type="gene ID" value="RA11412_0962"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0962"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="4">
        <location>
            <begin position="172"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="282" mass="28999" checksum="5D5FF96D1CD56BB4" modified="2018-10-10" version="1">MTEHIAFLGTGSMNGSIAAGLIAGGYPAEAIRATVRSKNSIDRLRHQLGPNGRDAVVIGCELNPEANREAVSGASVVLLGVKPYGIVELAREISPALAPDALVISVAAGVTLDTLQKALPAGQPVIRCMPNTPSSVGKGVLAISVSEAVTEKQLALAEKILETVGLVVQVREDQMDAVTAVSGSGPAYGFLLAETMASAGVKLGLDEETAQRLASATIAGAGYLLDSNPDAAALRKAVTSPNGTTERAINTFIDKGLFDLTEDAMRACAARSAELSEQYTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY67</accession>
    <name>A0A2Z5QY67_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2247 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Unnamed protein product</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_04105</name>
        <name evidence="1" type="ORF">RA11412_0987</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87286">
        <property type="protein sequence ID" value="BAV87286"/>
        <property type="gene ID" value="RA11412_0987"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0987"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016630">
        <property type="entry name" value="UCP015278"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10004">
        <property type="entry name" value="DUF2247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015278">
        <property type="entry name" value="UCP015278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT90089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="176" mass="20721" checksum="5B4F14FC9DEFE06A" modified="2018-10-10" version="1">MMLGTYYIGYEGIRKSALTWQGLRWGLAQGYISRADILRYASDRLKEDSSDLEYELYQCKPDHTYRIDGILAELAQHEDSPELTDPDPGSTDPRHALWLYLLLKHVYEHRKNFDDPLGEVEILHADFGYPEDVTPFVRYMPPTDYDPSTYTRQENIDKLYALWEAYLREAKTRFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY68</accession>
    <name>A0A2Z5QY68_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_03680</name>
        <name evidence="1" type="ORF">RA11412_1093</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87392">
        <property type="protein sequence ID" value="BAV87392"/>
        <property type="gene ID" value="RA11412_1093"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1093"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="341" mass="37660" checksum="87D8F047A2EC1A54" modified="2018-10-10" version="1">MTSADIILAVPSGPGWAPIHEMARLMASYLDARIVTPDPSASLKPATKILARVPRIRGKGRTAIVIASDPGQLYAIAQPRLVARRYAEIYGWVIDSFWDDRIPAIATNSTYNTVFVADRDDVHDWRSVGVKNVRVLPWGADVWSRFEEHLAHPKTTDLLRVGRQPAAYEDDERTAECARQTGITFAGRPPFGATDRESVESLQRALADAKFLLAFSTLVSPASYTHPNKEYITGRWTDALAHGVTVVGQVPKTESTREILWDGATVDIDPQDARAGLDAVAQLVNEWTPEQSRNQVRMALQRLDWRHRFAELFQVAGLNSPQLDADLMAIAAALADISPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY75</accession>
    <name>A0A2Z5QY75_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Minor extracellular serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_0885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87184">
        <property type="protein sequence ID" value="BAV87184"/>
        <property type="gene ID" value="RA11412_0885"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0885"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="131"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="352" mass="36012" checksum="4D8772C16D01F22E" modified="2018-10-10" version="1">MKEATGTVTAYVELAGQGAYGLALDGGGRRVSPMSQASPTAQSVAAAHHVQSQVVTNAQSLAASSNSQVLYTTHNLQRGVALTGDAQAIRGLAGHPDVVRISRIVPKERMNAISVVGTGALEAWRSTGATGQGVTIAVIDTGLDYTHADFGGPGTKAAYDKAKSSPTMPAGSYDPQKVVGGYDLVGDAYNGYNAPAPDSNPMDCSESGHGTHVAGTAAGYGVGADGKTFRGEYSKLSSADVQRLHIGPGSAPEARLMPLRIFGCSGSSSMTGQALDRALDPNNDGDFSDGANIVNLSLGSDYSTVDDPENTMLQRLIDKGVLAVVAAGNAQANLSQGDVYSIMGAPANNPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYA3</accession>
    <name>A0A2Z5QYA3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidyl-tRNA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87432">
        <property type="protein sequence ID" value="BAV87432"/>
        <property type="gene ID" value="RA11412_1133"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1133"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="83" mass="8709" checksum="C470ED5C64449257" modified="2018-10-10" version="1">MLMKSLGYMNVSGGPVSAVAKFYGIEPDHVVVVHDELDIPLTPSNLNAVEEKAGTTACVTLLKRSALKSTTVCVLVLAARPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYI9</accession>
    <name>A0A2Z5QYI9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clustered with transcription termination protein NusA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87535">
        <property type="protein sequence ID" value="BAV87535"/>
        <property type="gene ID" value="RA11412_1236"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1236"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="67" mass="7572" checksum="4D0B2178A4FF5970" modified="2018-10-10" version="1">MAITETDGSEYVGRLDEVTDDGPVLRRKKQTKKGQKPSYHEPQTLPWERIASAHLQIDFNSTADSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYK1</accession>
    <name>A0A2Z5QYK1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome C-type biogenesis protein DsbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03090</name>
        <name evidence="2" type="ORF">RA11412_1248</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888979.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87547">
        <property type="protein sequence ID" value="BAV87547"/>
        <property type="gene ID" value="RA11412_1248"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1248"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="100" mass="10318" checksum="6B1B88C04B9A04FC" modified="2018-10-10" version="1">MKVCPTLASVTGLLGGYKVASTTGNRPLGGAVLGVCGIIAFMNWKRKAGAPRATFLTGLYLGAFGASHPLAKKIGAWPSVYTVTGITALASILIGRKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYN5</accession>
    <name>A0A2Z5QYN5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA dimethylallyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87578">
        <property type="protein sequence ID" value="BAV87578"/>
        <property type="gene ID" value="RA11412_1279"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1279"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="210" mass="23521" checksum="68095BE3B787DD05" modified="2018-10-10" version="1">MRAALDKLELPGTDPAVRARLEEESRAHGIGALRARLADVDPDSAAKLNDERRIIRALEVYEVTGRPFSAFMPTREYVSDTLQIGLNMDRARLHERLHDRVVAMEKAGLLAEVEQLVDRGLRQGKTASRAIGYAQFLRAFEAQTSGADQRYTVAQAIEDTTVATRQFARRQLTWFRADPRVHWFDAESPTLLEDTLTLIQGYIAGSANLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYT0</accession>
    <name>A0A2Z5QYT0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87394">
        <property type="protein sequence ID" value="BAV87394"/>
        <property type="gene ID" value="RA11412_1095"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1095"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="42" mass="4530" checksum="2AF641B7AC298374" modified="2018-10-10" version="1">MAILVEDAPTADELAAALRRRGRFAIATQTPAEIAEELPYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYT5</accession>
    <name>A0A2Z5QYT5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="68" mass="7731" checksum="1335968AB1755978" modified="2018-10-10" version="1">MMPGNGASGVLWCDGRRTVDLRPGSRIEVRKSEKPVLLARIHPAPFSERIVRKFELPIRGWRGPQHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYT6</accession>
    <name>A0A2Z5QYT6_9MICC</name>
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    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">JCM 11412</strain>
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    </reference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="BAV87627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="208" mass="22817" checksum="F2A057283ECFF978" modified="2018-10-10" version="1">MAEAESRKILVFAHTGRKEAREAARQACTQLYRAGLTPVMNRSDLETLTENWADPVPVQVVHESVPLIDIELGVVLGGDGSILRAAEMVRRTTIPLVGVNLGHVGFLAESEESDLGETVERIVSGEYTVEERMAIEVEVWHESKRVHTDWALNEVSVEKGNREKMIEVIIEVDRKPLSTFGCDGVVMGTPTGSTAYAFSGADLLSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
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    <name>A0A2Z5QYU4_9MICC</name>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87645">
        <property type="protein sequence ID" value="BAV87645"/>
        <property type="gene ID" value="RA11412_1346"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="186" mass="19268" checksum="1D1B2A0B81E0C96D" modified="2018-10-10" version="1">MQKLYKLLAMVDDALIAPGATNTERLLGYGAGVCGAIFAGTTGALQGISGFGIVLLIVGGFDLFGGAVVNATPACSRRFHTGKRSRGSALGFIARHIHTLVLAAVLPTVMPWATAIVAYAGVLLAAALIVSVRSQYRPPVAFGLAVVLIAICLAIQPLSPAAVWVIPVLVIKLLLSHLLPHPTNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYV5</accession>
    <name>A0A2Z5QYV5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I6I94_02665</name>
        <name evidence="9" type="ORF">RA11412_1349</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transports L-lactate across the membrane. Can also transport D-lactate and glycolate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lactate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT89545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87648">
        <property type="protein sequence ID" value="BAV87648"/>
        <property type="gene ID" value="RA11412_1349"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1349"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="PTHR30003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00795">
        <property type="entry name" value="lctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="553" mass="57885" checksum="DB3B59CC462588D8" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYY6</accession>
    <name>A0A2Z5QYY6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87573">
        <property type="protein sequence ID" value="BAV87573"/>
        <property type="gene ID" value="RA11412_1274"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1274"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="156" mass="17290" checksum="4C3ACB9EBA8F6975" modified="2018-10-10" version="1">MPEQFTLNRGQVYMFSSGDFSPHNVLFGSARDTVRAFDAEGACIHHRGFPFVEAMLGFPSSPGYPNYEVNRERTVPRLFAALFGDTPLDTHLAEDLAVCAAVTACTLMELYSHGERAHLLGRIRRQSAELMMLLLRTGDSKDTALVDLAKRLGNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYZ9</accession>
    <name>A0A2Z5QYZ9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87705">
        <property type="protein sequence ID" value="BAV87705"/>
        <property type="gene ID" value="RA11412_1406"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1406"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005548">
        <property type="entry name" value="Cell_div_FtsQ/DivIB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03799">
        <property type="entry name" value="FtsQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsQ" evidence="1">
        <location>
            <begin position="41"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="177" mass="19151" checksum="476213A647A76AAF" modified="2018-10-10" version="1">MSEDRVRELVGSDGALRGVQMEIRPPHELVVTVKERVPIAAVKRGEKYALVDNEGQTLREVDSAQQAGVPIVQVEDENLSQSAAFRIISNVLVTLPTSLLAEVSEVKADSTSSITLILKDKVTVLWGTSQENEVKAKVLTKLLEATRSEDSQSSGAQGQGKKISVYDVSSPLLPVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZA2</accession>
    <name>A0A2Z5QZA2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87792">
        <property type="protein sequence ID" value="BAV87792"/>
        <property type="gene ID" value="RA11412_1493"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1493"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="166" mass="19206" checksum="CA1FC2E33BC939A8" modified="2018-10-10" version="1">MEEFDDYARALIASRRAYAQELGIEKCWGNISLAFKELNRQGVVAREAFSCCSRCGSWSIYDEADDSRDWYGYVFFSEQCAADISETASVYLQHGIFPPALRQQYSEQQWESMSQEERSAAHHRVTEQFLQERVIPVLERHGLQVRWGGDTTYCPNVMNIKYIAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZA6</accession>
    <name>A0A2Z5QZA6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="13" type="ORF">RA11412_1332</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87631">
        <property type="protein sequence ID" value="BAV87631"/>
        <property type="gene ID" value="RA11412_1332"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1332"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="CTP_synth_N" evidence="12">
        <location>
            <begin position="53"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="11">
        <location>
            <begin position="352"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="433"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="564"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="63"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="198"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="238"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV87631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="591" mass="64493" checksum="1088EC9579B95CDC" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZB6</accession>
    <name>A0A2Z5QZB6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">ftsZ</name>
        <name evidence="12" type="ORF">I6I94_02455</name>
        <name evidence="13" type="ORF">NCTC10207_00797</name>
        <name evidence="11" type="ORF">RA11412_1407</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="6">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888936.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87706">
        <property type="protein sequence ID" value="BAV87706"/>
        <property type="gene ID" value="RA11412_1407"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1407"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="9">
        <location>
            <begin position="12"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="10">
        <location>
            <begin position="206"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="336"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="20"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV87706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT89508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VEI22712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="403" mass="41364" checksum="0DEAE0E21C73A874" modified="2018-10-10" version="1">MDAGTPQNYLAVIKVVGIGGGGVNAVNRMIEVGLRGVEFIAINTDAQALLMSDADVKLDVGRELTRGLGAGANPEVGRQAAEDHAQEIEEVLKGADMVFVTAGEGGGTGTGGAPVVARIARSLGALTIGVVTRPFTFEGRRRSNQAETGISALRDEVDTLIVIPNDRLLSISDRNVSMLDAFKSADQVLLSGVQGITDLITTPGLINLDFADVKSVMQGAGSALMGIGSAAGEDRAVKAAELAIASPLLEASIDGAHGVLLSIQGGSDLGLFEINEAARLVQEVAHPDANIIFGAVIDDALGDEARVTVIAAGFDAVNPETNSNASAAAAVQAQAQRTQQTFGGQNAPTAAPAQPDYGFNAPAAPAYQQNDVPASAGFDVDLPPVVEEPPARRDTLDVPDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZQ2</accession>
    <name>A0A2Z5QZQ2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87952">
        <property type="protein sequence ID" value="BAV87952"/>
        <property type="gene ID" value="RA11412_1653"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1653"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="153" mass="15877" checksum="457ECB33F0F260A2" modified="2018-10-10" version="1">MLAGSFAPAAAAEEPVTDPSATISYEDVPPPTEDMNTAMGAGERKRLGLPAEGATEAPGGHGRAKGVGPAATWTPSGGTLGMDVSSHQGNVRWQEAYNGGARFAYTKATEGTYYTNPYFAQQYVGSADVGMIRGAYHFANPAPPQVPTRLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZS0</accession>
    <name>A0A2Z5QZS0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein FtsQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87704">
        <property type="protein sequence ID" value="BAV87704"/>
        <property type="gene ID" value="RA11412_1405"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1405"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="94" mass="10659" checksum="E1E67B730CF4FE4D" modified="2018-10-10" version="1">MREHNRREQIRRDPALDGLRAEDKVEPERAPLSRMRKLAYTALALVLVVALYIGVVFFSPLLAVEKITVRGASLMDSAQVEQKLSSLRGFHYHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZV5</accession>
    <name>A0A2Z5QZV5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87821">
        <property type="protein sequence ID" value="BAV87821"/>
        <property type="gene ID" value="RA11412_1522"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1522"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="446" mass="49008" checksum="3F735966062ADDF8" modified="2018-10-10" version="1">MDNGTNTETALEFDQHPAKTAQVRLKDFPRGSISHIFRRAGFNFLSSNGTDSAAALTYFTVLSIFPGLLAFVSLLGIVGQGQESATVILEFLQENAPQQMYSIVENPIRQLTNGQGAGIALLIGILSALWSASGYISSFGRAINRIYGVREGRPVWVLIPFNILITTAVVVLAVLMMLMLLLGVDVLNIIGSHLPPHVDIELVKVLWLNGRWVLIFLAAVGLIAMLYTATPNIRHEKMRRMSPGAFVALTGMALGSFGFTLYTDNFSKYNATYGLIGGVIVMLLFTWIMNNMLLYGAHLDAEIERMRQLVAGERSEDIIRVEVRDDRALKILDHKNETLISQANMLQRKSGGQQIMPKPKGPSLAQQVSQKVTATFEQVQGKADQVRGMFDNSQTPANPPTLPHYPRQIPRRITPTDPMKTPTSPRFSSVRFSGTGSGGRTDSYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZZ5</accession>
    <name>A0A2Z5QZZ5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">COX15/CtaA family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Cytochrome oxidase assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_01090</name>
        <name evidence="7" type="ORF">RA11412_1753</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88052">
        <property type="protein sequence ID" value="BAV88052"/>
        <property type="gene ID" value="RA11412_1753"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1753"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="351" mass="38674" checksum="A0CFB9F6FB591A83" modified="2018-10-10" version="1">MITTLKDKLSPTEYTPWVLYTAVGTALANLLLIVTGAVVRLTGSGLGCDTWPRCTDEQWTTTPAQGIHGFVEFGNRMLTFVLMVITVLAFFAVLRLALPQATVRSVLPKLFTGLRTQNSRYSDLFNLTLLLLWGIPLQAVIGGITVWQRLNPWMVTAHYMASAVMIGLAAVLINRVRRYFKPATAAAENLDSAFSEKGRVSVQVLGWFGLVLVVFLVFMGTVVTGTGPHAGDPRTHRHDFNPIVIARLHAWAVWVYLVSLMTLYLIVRAYALPKAYKFSLAVLTGVIACQGTIGYIQYNTGLPALLVEAHMLGSGLFTWAAISLIERQLTLTSRTARELALSRRVQHTSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R053</accession>
    <name>A0A2Z5R053_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Undecaprenyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88097">
        <property type="protein sequence ID" value="BAV88097"/>
        <property type="gene ID" value="RA11412_1798"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1798"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="197" mass="22722" checksum="2AD483AEA9460465" modified="2018-10-10" version="1">MGIPYISAYAFSTENWKRSPSEVAFIMRFSTEVLNRQLETLKSWGVRIRWAGRRPKLWKNVIEQLEQCERETRNNTICTLTMCVNYGGRAEIADAAAAIARDVQAGTLKPNAITEKTFQKYLDEPDLPDVDLFLRSSGEQRISNFLLWQSAYAEMVFMNVLWPDVDRRTLYKAVEEYAHRDRRYGGATDKIPAQTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R067</accession>
    <name>A0A2Z5R067_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Cytochrome bc1 complex cytochrome c subunit</fullName>
            <ecNumber evidence="3 10">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">qcrC</name>
        <name evidence="16" type="ORF">I6I94_00860</name>
        <name evidence="17" type="ORF">NCTC10207_01135</name>
        <name evidence="15" type="ORF">RA11412_1809</name>
    </gene>
    <organism evidence="15 18">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="16 20" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 20">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 2 heme groups covalently per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3 10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887239.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88108">
        <property type="protein sequence ID" value="BAV88108"/>
        <property type="gene ID" value="RA11412_1809"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1809"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009152">
        <property type="entry name" value="bc1_cytC-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000007">
        <property type="entry name" value="Ubiq_cycred_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340108" description="Cytochrome bc1 complex cytochrome c subunit" evidence="13">
        <location>
            <begin position="41"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="14">
        <location>
            <begin position="49"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="14">
        <location>
            <begin position="144"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000007-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000007-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV88108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QQT89221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VEI23038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="264" mass="27675" checksum="3593384670DA758F" modified="2018-10-10" version="1">MKALSQKRRHPLAAVVLLALALILTGGLYTVATATNQAKAESNHAYTQQDVEAGQKLFQANCATCHGTNAEGTADGPSLIGVGAAAVDFQVGTGRMPMQMQGTQAQIKPGQFNEEQTRQLSAYVASLGAGPTIPETAYLDTTQGDAANGARVFLANCAMCHNAAGAGGALTRGKFAPTLMGVKEQHIYEAMETGPQNMPVFNDANLTPEEKRDVITYLKAQEKNVSPGGMKLGSLGPVSEGLLIWTVGLGIVIVFVIWLTSRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R076</accession>
    <name>A0A2Z5R076_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88118">
        <property type="protein sequence ID" value="BAV88118"/>
        <property type="gene ID" value="RA11412_1819"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1819"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="284" mass="30258" checksum="E0F7330D02216219" modified="2018-10-10" version="1">MVEMYRLPQDIKLTGEFPGPVSRALGQRRSAAVPASVASGMPVYAVDADGGVIVDADGNSWADLGSGIAVTSVGASAPKVVQAVQEAVAHFTHTCFMVTPYEGYVAVAEKLNELTPGNFEKRSVLFNSGAEAVENAVKIARAATGRNAVVVFDHAYHGRTNLTMALTAKAAPYKKGFGPFAPEIYRAPMSYPYRDEPTMDGKEAAQRTIDVIEKQIGSEYVAAIVLEPIQGEGGFIVPAEGSCLPWFRGLVRRASCSSRMRFSPVSVVLANGLPASMMGLNLIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0B1</accession>
    <name>A0A2Z5R0B1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-hairpin-helix domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Putative ComE operon protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_00695</name>
        <name evidence="4" type="ORF">RA11412_1858</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88157">
        <property type="protein sequence ID" value="BAV88157"/>
        <property type="gene ID" value="RA11412_1858"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1858"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="457" mass="47908" checksum="E1BECE2AFCF07590" modified="2018-10-10" version="1">MNEPNHTTAHPNGETNIPPETAPGTAYREQKTPRPDTTAPGDGTPTEQDDDPTLALNREQLIPHAAGPEAKEPQELPPEPEPEEKQRDAAAHYLDRIRERSTPPAETAHYTAPHDDPDPHATTPPEDEDDELAREEPGGYRTTYARSLDEYPDYLEEYARLRRVSVREEPEDPYRDQDPSGLITRRDYFPDEWEEYAPRGNRSIRSYVSPKALIALGVVACVITVWAIFQMGAAPRASEASEPTAPHGGVEQSQPTPQRSASASAEPSHTAQGSAAPNPEPSKGTIRVHVAGAVKAPGVHTLPADARAVDALTAAGGATGEADLNRVNLAGSLSDGVQLYIPKEGEEIPQAPANGGAGGSGTAGASQGASKPAAGGASASASAGAKGSASAASGGQVNLNTATAEQLQTLPRIGPALAARIIAWRDEHGGFKSVDELDAVPGIGPAMMTSLRPLVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0B7</accession>
    <name>A0A2Z5R0B7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87914">
        <property type="protein sequence ID" value="BAV87914"/>
        <property type="gene ID" value="RA11412_1615"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1615"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="68" mass="7670" checksum="55D727E3B2A00721" modified="2018-10-10" version="1">MSYPQAFYAISCFKMWFKTLIVKKCDVFMSGPLQAPHAGIKSFGQTHGLPETFKVCLSQQIPQAFELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0E1</accession>
    <name>A0A2Z5R0E1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type I restriction-modification system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="162568">
        <property type="entry name" value="S2.Rae11412ORF1692P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87990">
        <property type="protein sequence ID" value="BAV87990"/>
        <property type="gene ID" value="RA11412_1691"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1691"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="200" mass="22080" checksum="04F86293E6268865" modified="2018-10-10" version="1">MSDVRMVKLGDIGQVISGATPKTSVPEYWGGDIYWATPKDLSRLESAYIDSTERTITESGKASCATSILPENSVLLSSRAPIGHVAINTTPMATNQGFKSIIPTNDVIPKYLYYWLSANKYYIQSMGNGATFKEISKKVVESIVLPLPPLEEQKRIVSILDKAKSIQEARERQLAALDELSYSIFVDFSDLQISGARNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0E4</accession>
    <name>A0A2Z5R0E4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">L-lactate dehydrogenase</fullName>
            <shortName evidence="6">L-LDH</shortName>
            <ecNumber evidence="4 6">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ldh2</name>
        <name evidence="6" type="synonym">ldh</name>
        <name evidence="13" type="ORF">I6I94_00925</name>
        <name evidence="14" type="ORF">NCTC10207_01122</name>
        <name evidence="12" type="ORF">RA11412_1794</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of lactate to pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(S)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Allosterically activated by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="4 6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037234409.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88093">
        <property type="protein sequence ID" value="BAV88093"/>
        <property type="gene ID" value="RA11412_1794"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1794"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="10">
        <location>
            <begin position="9"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="11">
        <location>
            <begin position="150"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine" evidence="6">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV88093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT89234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VEI23025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="319" mass="33714" checksum="06DABB4F011C5CCF" modified="2018-10-10" version="1">MNGETRPTKLGIIGAGGVGSATAYAATLRGSASEIVLYDIDGKRAHAEALDIAHGSMFAHEANIIGGSELETLKDADMIIITAGARQEPNQPRMELAGANVRILEKLLPDLMSVAPGAIYMLVTNPCDVLTVVTQKITGLPANRVLSSGTVLDSSRLRWLIAAKAGVSIKSVHANIVGEHGDSEFPVWSAANIGMVPLTEWEHNGQKLFTQDVRDSLAHDAMRAAYNVIAGKGSTNYAIGVSASRIAEAFLQGQNAVLPVSTTMAGKMYGFNNVALSLPSIVSRDGVQRVLEVPMDDNEHAKLRASAEAIRASLDTLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0E8</accession>
    <name>A0A2Z5R0E8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_1946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88245">
        <property type="protein sequence ID" value="BAV88245"/>
        <property type="gene ID" value="RA11412_1946"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1946"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="224" mass="24414" checksum="31AEA3F97613C5C4" modified="2018-10-10" version="1">MSAPVFYVAPQEFDPLTPGTDFELTGPEGHHAKVKRVENGERIDLADGQGRRALGTVEATTTSGIRVRIIEIQHDKNPLEVYVVQALAKDGRDVQAIETATELGATGVVPWGADRSIVRWKGERAAKAHTKWRNTVVAAAKQSRRSRIPTVYDLHSTPELAELIAEVRAQGAAVFILHEQASERLTTLLGQSAGERLGEIYLVVGPEGASANVKLRCSRRRVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0F5</accession>
    <name>A0A2Z5R0F5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name evidence="3" type="ORF">I6I94_00490</name>
        <name evidence="2" type="ORF">RA11412_1899</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88198">
        <property type="protein sequence ID" value="BAV88198"/>
        <property type="gene ID" value="RA11412_1899"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1899"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="144" mass="15643" checksum="69E592F2E4E1AF1B" modified="2018-10-10" version="1">MRVILQRVSRASVRVENKIVGAIEETGYLALVGITHEDGETQLAKMADKTANLRLFEGEKSALEVDAPILAVSQFTLYGDAKKGRRPSWSKAAPGAVSEPLFEAFVQKLRNTGLRVETGIFGADMQVELVNDGPVTLILDSETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0G7</accession>
    <name>A0A2Z5R0G7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 76</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Predicted glycosyl hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Putative glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_07955</name>
        <name evidence="3" type="ORF">NCTC10207_02025</name>
        <name evidence="1" type="ORF">RA11412_0050</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86349">
        <property type="protein sequence ID" value="BAV86349"/>
        <property type="gene ID" value="RA11412_0050"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0050"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI24323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="423" mass="45810" checksum="34EE71CE792F9DA4" modified="2018-10-10" version="1">MESTHTSQAPTHTAADYAQRAADRARLAADSVLHQFAHRPLGVPGTLLGSVQVPETRPLSKRLKDWHYWWQAHFLECVVDAGERELHAGNRLGASEWLSRARALVRGINARNLGTFVNGFYDDMAWLALAAGRMNELSRAMNGGEGDTGAQDAGNVLFPQLRSGMSPYGGVSWSKQKRDFINTPATAPTALAFARAGDVADASALVTWLNNTLWDAERSLYIDGVNVRTGKVRDVVGARDIDLDYEQNIYTYNQGTALAALLAVAERSPEQAHSLVRRAEQLIVGIVTHLSEEFVFSDGQRGRVLASGGDGDGALFTGILVRYLAQAAQCELLSKDARLLAASLVHGSARAVWEGRREFDPELPLSEPGVNTSEIRGDAVAVFSPKFTEQAHTVLPAGTPVELSGQLQAWMVLEASALLTRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0M8</accession>
    <name>A0A2Z5R0M8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88036">
        <property type="protein sequence ID" value="BAV88036"/>
        <property type="gene ID" value="RA11412_1737"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1737"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="69"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="558"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="769" mass="85638" checksum="579A2608336D3BCD" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0R9</accession>
    <name>A0A2Z5R0R9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="2">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_1973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88272">
        <property type="protein sequence ID" value="BAV88272"/>
        <property type="gene ID" value="RA11412_1973"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1973"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="301" mass="32254" checksum="671E035729100A3C" modified="2018-10-10" version="1">MMTKPFPSDLEIAQAATLEPITEIAAENGISADRLEPYGKYVAKVLLDETTNAETARKRGSKYIVVTAVTPTPLGEGKTATSVSLAQGFAQTGRKAMLTLRQPAMGPTFGIKGGAAGGGYSQIVPMEKLNLHLTGDFHAVTAAHNLLAAMIDNHLHQGNDLRIDPRAIEWRRVIDINDRSLRNVVVGLGERIDGVPRQTGFDITSASEIMVILSLATSFKDLRERLAKIVVGLNYDGEAVTAADLKADGALAVILADAINPNLLQTLEHTPALIHAGPSVISLPVTHQSWRTMLVSNIRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0T0</accession>
    <name>A0A2Z5R0T0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutaredoxin-like protein NrdH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nrdH</name>
        <name evidence="6" type="ORF">I6I94_00195</name>
        <name evidence="7" type="ORF">NCTC10207_01266</name>
        <name evidence="5" type="ORF">RA11412_1983</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">FDAARGOS_1137</strain>
        </source>
    </reference>
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        <text evidence="1">Electron transport system for the ribonucleotide reductase system NrdEF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT89102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887234.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88282">
        <property type="protein sequence ID" value="BAV88282"/>
        <property type="gene ID" value="RA11412_1983"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1983"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011909">
        <property type="entry name" value="GlrX_NrdH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02194">
        <property type="entry name" value="GlrX_NrdH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VEI23169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="79" mass="8713" checksum="6E574C1371262642" modified="2018-10-10" version="1">MVVTVYTKPQCVQCNMTYRALDAKGINYHKVDITEDDRALAKVKSLGYMQAPVVIAGEDHWSGFQPDRINALADIAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0T6</accession>
    <name>A0A2Z5R0T6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I6I94_00870</name>
        <name evidence="10" type="ORF">RA11412_1807</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887101.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88106">
        <property type="protein sequence ID" value="BAV88106"/>
        <property type="gene ID" value="RA11412_1807"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1807"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="9">
        <location>
            <begin position="19"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="553" mass="61604" checksum="A5FB59EBB930C8ED" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R119</accession>
    <name>A0A2Z5R119_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Magnesium and cobalt efflux protein CorC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_1941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88240">
        <property type="protein sequence ID" value="BAV88240"/>
        <property type="gene ID" value="RA11412_1941"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1941"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016417599" evidence="6">
        <location>
            <begin position="23"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="7">
        <location>
            <begin position="11"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="240" mass="26105" checksum="2D5A9890E5A77F8E" modified="2018-10-10" version="1">MTFLLLLSAAVLAATCAYTITAAETAFTYLPHQEAQELALKRPHTRLARVLEHATGGESERYTHPLRLARILSTAIASLTTMLAILELIDQHSVAAVLTLGVVSLVGYPLLSVGARATGRNRSVAVLKMLAAPTYYTALLLGPITRALDVLVRVFSPRRTPAAPEGVFAQEELREFLDRASEAETIEGDEAQIVQSVFEMDDTRIRSIMVPRTDMLTIEAGETLKMPPRCFFAPATPGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R125</accession>
    <name>A0A2Z5R125_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88447">
        <property type="protein sequence ID" value="BAV88447"/>
        <property type="gene ID" value="RA11412_2148"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2148"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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            <end position="795"/>
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            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="380"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="639"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="801" mass="83251" checksum="79DA9AC6DFE9DE63" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">I6I94_06915</name>
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        <dbReference type="NCBI Taxonomy" id="172042"/>
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        </lineage>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86589">
        <property type="protein sequence ID" value="BAV86589"/>
        <property type="gene ID" value="RA11412_0290"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0290"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="4">
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            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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        <location>
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            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="29"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="552" mass="59312" checksum="5640DAE7BFF94907" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R170</accession>
    <name>A0A2Z5R170_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cysE</name>
        <name evidence="7" type="ORF">I6I94_10940</name>
        <name evidence="8" type="ORF">NCTC10207_01388</name>
        <name evidence="6" type="ORF">RA11412_2123</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887821.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88422">
        <property type="protein sequence ID" value="BAV88422"/>
        <property type="gene ID" value="RA11412_2123"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2123"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CysE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01172">
        <property type="entry name" value="cysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI23288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="194" mass="21263" checksum="C158FDBA72EDBA9A" modified="2018-10-10" version="1">MGFIARLREDIANVRQHDPAARGTVEIILNYSGMHAIWSHRLSHRLWQRDTTKALARSISQFTRFLTGVEIHPGATIGRRFFIDHGMGIVIGETTEIGDDVMLYHGVTLGGRSLEKVKRHPTIGDRVTIGAGAKVLGPVQIGADSAIGANAVVVNDHPHDSIITGIPAKSRPRTPEKKKPLVDAVEYIDPAMWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R195</accession>
    <name>A0A2Z5R195_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88423">
        <property type="protein sequence ID" value="BAV88423"/>
        <property type="gene ID" value="RA11412_2124"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2124"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="96" mass="10269" checksum="E0EE8A91F3855DD7" modified="2018-10-10" version="1">MKVDVEVKANGKARVSYGPYSSTSTENISSDWRKEGIETTLKDSYTLNASGSYGDGGATKVSCKITVNGETVSENQASGTYSTVSCHIPYSYVPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1F6</accession>
    <name>A0A2Z5R1F6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_2081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88380">
        <property type="protein sequence ID" value="BAV88380"/>
        <property type="gene ID" value="RA11412_2081"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2081"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="107" mass="11616" checksum="5ED4B2F34A79CB3E" modified="2018-10-10" version="1">MEAIFGATYMTLGREAARELVLRLIAPLLDDEAVLNSGRDWKTDLQELVASRAWGEVRYEVSGEGPDHARHYTAKAVVAGQVAGTGEGTSKKEAERLAAEAAYRVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1M3</accession>
    <name>A0A2Z5R1M3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-54 factor RpoN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_2263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88562">
        <property type="protein sequence ID" value="BAV88562"/>
        <property type="gene ID" value="RA11412_2263"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2263"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014293">
        <property type="entry name" value="RNA_pol_sigma70_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02947">
        <property type="entry name" value="SigH_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="51"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="156"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="232" mass="26809" checksum="4B22AA229660215D" modified="2018-10-10" version="1">MQVCWRKTLNADVPSWWRQEREQMSEINAAEATKTLDSRELRTRFTTDAMQYVDQLYAAALRMSRNPADAEDLVQETYTKAFASFHQFKQGTNLKAWLYRILTNTYINLYRKRQREPQTANAEAVNDWQLARAGEHDAVGLRSAEADALAALPDTEVREAFSALAEDFRMVVYYSDVEGFSYKEIAEIMDIPLGTVMSRLHRGRRILREKLVDYARENGVRPSTIEKALSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1M4</accession>
    <name>A0A2Z5R1M4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FtsK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88588">
        <property type="protein sequence ID" value="BAV88588"/>
        <property type="gene ID" value="RA11412_2289"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2289"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="2">
        <location>
            <begin position="140"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="158"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="917" mass="97940" checksum="122A298781AE7569" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Z4</accession>
    <name>A0A2Z5R1Z4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulatory protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Zinc ribbon domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_09500</name>
        <name evidence="3" type="ORF">RA11412_2478</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88777">
        <property type="protein sequence ID" value="BAV88777"/>
        <property type="gene ID" value="RA11412_2478"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2478"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="76" mass="8201" checksum="5D1349A5D227129E" modified="2018-10-10" version="1">MPIYVYQCKNCGHAFEKRQSFSDNALRTCPSCGQETLRKRYNEVGVVFKGSGFYTNDKNSSTNSSSSSSGSSAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R201</accession>
    <name>A0A2Z5R201_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Para-aminobenzoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86919">
        <property type="protein sequence ID" value="BAV86919"/>
        <property type="gene ID" value="RA11412_0620"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0620"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="2">
        <location>
            <begin position="24"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="159"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="453" mass="49710" checksum="0BD3831908F857D4" modified="2018-10-10" version="1">MSRVSYVGVVPHWAAVLRIENACEATNTTPWDALDTALASMPEPDDIAELPEGLRGGYVGYFGYEARAALHPGRIGYTPRHTAQTPDSLWMPAVRYLVYEHETHRAWLLGDKPWFEEIEPRLRELARDSWREIPGDNAHDGDKPLSQHVEHLHFEAPERESYCADIERAQWHIYEGNSYEVCLSAESTARVEHPLTPDQLFELYRTQRRHNPAPYAAYLRCGDFSVLSSSPERFLMVDIQGNAETKPIKGTCPRGANPQDDAAAAHWLQHDAKTRAENLMIVDLLRNDLSTVSDPASVQVPVLMGVESYATVHQLVSTVTARLKPEISAVHASAACFPGGSMTGAPKPSTMNIIEDLEARPRGVYSGALGFFSADGGANLSIVIRTLVAHDNGLITLAAGGAIVADSDPNTEYEEMLTKLRAALPPSVGHIVEKGVRKQNVAAIADRESPGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R237</accession>
    <name>A0A2Z5R237_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">alr</name>
        <name evidence="8" type="ORF">I6I94_09320</name>
        <name evidence="7" type="ORF">RA11412_2516</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037234598.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88815">
        <property type="protein sequence ID" value="BAV88815"/>
        <property type="gene ID" value="RA11412_2516"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2516"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="272"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="438" mass="46688" checksum="9D0E0A6140F5C6A7" modified="2018-10-10" version="1">MNTPESAIPGTPIANVQLQPGEAERAAIIDLSAVEHNVRTLKHRIGERQLIAVVKADAYGHGAYPVARSVLEAGADMLAVVHVSEALELRSEGIEAPIIAWLHTPRTDFEEAIEADVRLGVSGWDLEAIAIAAAKLRMRAIVHLKADTGLGRNGSTDTEWPALISRAAELEAAGLIRVEGIFTHFAVADEPERAETAQQTEKFNKFVAAARAAGLTPDLIHLANSPATLTGASEEYNTPEAVLGNAVRCGLAIYGLSPLAGVSAQQLGLRPVMTLTGYVSAVKEVPAGQGVSYGLRYTTDKPTTLALIPLGYADGVPRIAANAPVRIYPRDAEAKTYRVVGRIAMDQLVVDLGEPGLSNPELGYLGARAVLFGASPNPPVEEWAEASETINYEVVTRISPRVIRIYSGGTWIEREIDVLHSLDEALKDIDTSVPEGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R240</accession>
    <name>A0A2Z5R240_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">lipA</name>
        <name evidence="9" type="ORF">I6I94_10510</name>
        <name evidence="8" type="ORF">RA11412_2242</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88541">
        <property type="protein sequence ID" value="BAV88541"/>
        <property type="gene ID" value="RA11412_2242"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2242"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="67"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="335" mass="37299" checksum="743ACB92DE3C74A4" modified="2018-10-10" version="1">MSIKPEGRKLLRVEARNAEVPIEKKPHWIKTKAVVGPEYNEMRELARGQGLHTVCEEAGCPNIYECWEDREATYLIGGSECTRRCDFCNIATGKPASVDYAEPFKVAKNVKVMGLRYATVTGVARDDLEDGGAWLYAETTRQIHKMCPNTGVEMLIPDFKGKPEHVQKVIDARPEVFAHNLETVPRIFRQIRPAFRYERSLDVITQGKEAGMVTKSNLILGMGETNEEIYEALCDLHDAGCDIITLTQYLRPGPLFHPIERWVKPAEFLELSAMAESIGFAGVMAGPMVRSSYRAGRLWARAMKKNGYTIPDNLAHIEDGGVALQEAASLVAAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2B8</accession>
    <name>A0A2Z5R2B8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rplD</name>
        <name evidence="8" type="ORF">I6I94_09100</name>
        <name evidence="7" type="ORF">RA11412_2569</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037234081.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88868">
        <property type="protein sequence ID" value="BAV88868"/>
        <property type="gene ID" value="RA11412_2569"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2569"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="205" mass="21860" checksum="0F92283A008B08E9" modified="2018-10-10" version="1">MAVKTLKVDLPAEIFDAQASVPLLHQVVVAQLAAARQGTHKTKNRGEVSGAGRKPFKQKGTGNARQGSIRAPHMTGGGVVHGPTPRNYAQRTPKKMIAAALRGALSDRARHGRIHVVETLVAGETPSTKAAKAALASITERKNVLVVIGRDEDIAALSARNLQNVHVLYADQLNTYDVLISDDVVFTKAAYDAFVTANQKKEGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2D3</accession>
    <name>A0A2Z5R2D3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH pyrophosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_09860</name>
        <name evidence="5" type="ORF">RA11412_2395</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88694">
        <property type="protein sequence ID" value="BAV88694"/>
        <property type="gene ID" value="RA11412_2395"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2395"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="162"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="306" mass="34062" checksum="B89EB969C00602B9" modified="2018-10-10" version="1">MSTQNKKLPAHTTVTDETASRRTRYLVVSRSGDTLVGADGTLHYLDSPPEDSLTDVSLEPKLMKPEARYAIEYRAVYVEDADLAALTQELGALPEGCEVSTAGFWFYPVHADPAGRARYGAALAKRDYLIEMAYSAYTGESAPVDPHKGIRLTGSGEMVFPRIEPAVMALIMSEDNSRVLLANNRLWPRNRFALIAGFVDPGENLEQAVTREVYEETGLDALRLDYRMSDIWPFPRSLMVCYRVTVDASQPVTHLDGEIHSARWFTAPELAQAIAEQRTGEPKLELPGTNAVARRMLDEWLQEKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2D6</accession>
    <name>A0A2Z5R2D6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-acetylhomoserine sulfhydrylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87059">
        <property type="protein sequence ID" value="BAV87059"/>
        <property type="gene ID" value="RA11412_0760"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0760"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="310" mass="32732" checksum="70792B20006CE056" modified="2018-10-10" version="1">MDATISTPYLIRPLEHGADIVIHSATKFLGGHGTTLGGVVVESGRFNWANGNFPLMTEPVPSYNNVSWWGNFGEYGFLTKLRSEQLRDFGPALSPQSAFNLLQGVETLPQRMDAHLANAKKVVDWLVEDARIAYVNYAGLPGHAHHERAKKLLPLGVGSVFSFGVKGTEKASGRVVGGEFISALVLASHLANIGDSRTLVLHPGSTTHQQLSSEQLAAAGVGEDLIRISVGLEDVEDIIWDLDQALTHATGLNHAGERVGESSADKLVAAQEALAAEEADPQQGAACALPKSTAASGASESKDAPAKEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2F7</accession>
    <name>A0A2Z5R2F7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="7">RNAP subunit beta'</shortName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpoC</name>
        <name evidence="12" type="ORF">I6I94_09055</name>
        <name evidence="11" type="ORF">RA11412_2584</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88883">
        <property type="protein sequence ID" value="BAV88883"/>
        <property type="gene ID" value="RA11412_2584"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2584"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="10">
        <location>
            <begin position="310"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="882"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="955"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="962"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="965"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV88883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT88660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="1300" mass="144215" checksum="BA11924112CF0676" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2I3</accession>
    <name>A0A2Z5R2I3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GlsB/YeaQ/YmgE family stress response membrane protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transglycosylase associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09695</name>
        <name evidence="2" type="ORF">RA11412_2435</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887449.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88734">
        <property type="protein sequence ID" value="BAV88734"/>
        <property type="gene ID" value="RA11412_2435"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2435"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="81" mass="8446" checksum="CE31DB4CB4013094" modified="2018-10-10" version="1">MGTIIGSIITGAIIGALARVFMPGRQNISIIWTIILGAVGAFVGTWVAGFFGVAHTAGIDWIRWAAAMLAISVYLGVTGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2J3</accession>
    <name>A0A2Z5R2J3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88770">
        <property type="protein sequence ID" value="BAV88770"/>
        <property type="gene ID" value="RA11412_2471"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2471"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="57" mass="6040" checksum="23B29489A697885F" modified="2018-10-10" version="1">MEVDGPKTSVNFISESSQETITPGRIKAKHTGGHWVISFETDESASPSASSSRSSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2K0</accession>
    <name>A0A2Z5R2K0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88985">
        <property type="protein sequence ID" value="BAV88985"/>
        <property type="gene ID" value="RA11412_2686"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2686"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="136" mass="15050" checksum="6C7C58962B5E32A0" modified="2018-10-10" version="1">MWEYLEPVLDEKIAASERHYGVVQSVRAELLRMIPSGSYSLEKLSSHLGVSGRTLQRELQQAGTSYQHECSQAQSELACSYLKNPAAGLQDVALLSGYTEVSSFTRAFKKWTGLTPGQYRDQLSSQENTTNTVNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Q6</accession>
    <name>A0A2Z5R2Q6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine oxidase ThiO</fullName>
            <ecNumber evidence="4">1.4.3.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thiO</name>
        <name evidence="4" type="ORF">I6I94_08370</name>
        <name evidence="3" type="ORF">RA11412_2748</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.19" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89047">
        <property type="protein sequence ID" value="BAV89047"/>
        <property type="gene ID" value="RA11412_2748"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2748"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012727">
        <property type="entry name" value="Gly_oxidase_ThiO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02352">
        <property type="entry name" value="thiamin_ThiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="5"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV89047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="351" mass="37497" checksum="E18BE9C52350ED00" modified="2018-10-10" version="1">MAEVITVVGGGIIGLTTAFELTERGQRVRVYDPTPGERGTGASYFAGGMLAPIAEVQFQQDALFPLMVSSANAYPSLMRRLAAVTDAPTGYDTTGTLVVAGDRADAAHLRDVSEYYRSINRSAEAIPVSRARALEPALAPDLAGAALIEGDHQVAPRLFLQALVKALRARGVEFVRERVTDSDFGDIVCTGLGAAGQYPLRPVYGDILRLQAPHPLVEHVVRGFVNGRPVYVIPRPGGEVCIGATSREDTRTRPGVDGVYQLLKDAIRVVPAVEECELIESNVGVRPGTPDDLPIFGDRTTATGRRQLISNGYFRHGILLAALAGKAGAEVFLGGDIPPEFAPCSPKRFEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R303</accession>
    <name>A0A2Z5R303_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peroxynitrite isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_2631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88930">
        <property type="protein sequence ID" value="BAV88930"/>
        <property type="gene ID" value="RA11412_2631"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2631"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4_heme-bd" evidence="3">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00026233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="197" mass="21687" checksum="AE9704750356CABE" modified="2018-10-10" version="1">MWYKEQEKTPFGQIITFTQDGLPYLEYRAESFLLDDSGQKLRPITIETGFWQIDRPLTDADGGFGLVPKDIVPAFADAESVETLRNEDDGFNLIATIAHPGGISENYVGMVKGPVVRMQTANLIRDDISHQYAGSVRLWGLVNGNLMWDWEIADNEGNLHKHASAELRKTSSMSGDSLGTGMFGSLDDGAEEGSAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R340</accession>
    <name>A0A2Z5R340_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88990">
        <property type="protein sequence ID" value="BAV88990"/>
        <property type="gene ID" value="RA11412_2691"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2691"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="149" mass="15677" checksum="265830355F1B4EE8" modified="2018-10-10" version="1">MGTYRGQQLDEDALNEYGKQFSGYEGPTLKALDNLPYVVVALAVVGLVLVLIWKHHFVSAVVGVFTAAAATVSTQLLKNTLVKPNYGVQEAVLNSAPSGHTTLAAAAGAAIFLAAPRSLRPAVAVLGSLATCLTGMATMINNWHRPGMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R379</accession>
    <name>A0A2Z5R379_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribose-phosphate pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87399">
        <property type="protein sequence ID" value="BAV87399"/>
        <property type="gene ID" value="RA11412_1100"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1100"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="1">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="81" mass="8716" checksum="7E32343A1CBF0121" modified="2018-10-10" version="1">MSHEITNPGVRKLAVVSGRAHPKLAEEIAAELGHPLLPTSAYTFANGETYVRFEESVRGADAFVIQSHPAPLTSGSWSRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3X0</accession>
    <name>A0A2Z5R3X0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Beta-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_00980</name>
        <name evidence="1" type="ORF">RA11412_1780</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887323.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88079">
        <property type="protein sequence ID" value="BAV88079"/>
        <property type="gene ID" value="RA11412_1780"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1780"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="238" mass="25701" checksum="62BA6E43D0326DD5" modified="2018-10-10" version="1">MSETTPKTVLVTGGNRGIGYEIAKEFKAAGHNVCVTYRSGDAPEEFFAVKADVRDSSSITEAFKTIEEQFGPVEVLIANAGITRDTLLLRMKEEDFTDVIDTNLTGSFRVVQRAIKGMLKIKRGRIILVSSVVGLYGSPGQVNYSSSKAALVGMARSITRELGGRNITANVVAPGFINTAMTEVLPEETKQNYLDTIPAKRFAEPEEVARVIRWLASDEANYISGAVIPVDGGLGMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R428</accession>
    <name>A0A2Z5R428_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Magnesium and cobalt efflux protein CorC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88239">
        <property type="protein sequence ID" value="BAV88239"/>
        <property type="gene ID" value="RA11412_1940"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1940"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="39"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="203" mass="22150" checksum="433BD59488176775" modified="2018-10-10" version="1">MPVIGESTDDILGILYLKDAVRARLATADSAHGGEEPTIISLMRPAHFEPESKPALDLLRRMQRESTHVAIVVDEYGGTAGMITLEDIIEELVGDIADEYDNEKPDYALQEDGSFKVSARLGVEQLGEIFGINLEDEEVDTVGGLLAKNLGKVPIVGAEVTVNGIHIRAISAGGRRHQIDTLLVWAQPPHEPEQNHSHEETDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R461</accession>
    <name>A0A2Z5R461_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MptD family putative ECF transporter S component</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Substrate-specific component BL0695</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00040</name>
        <name evidence="2" type="ORF">RA11412_2020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88319">
        <property type="protein sequence ID" value="BAV88319"/>
        <property type="gene ID" value="RA11412_2020"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2020"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011733">
        <property type="entry name" value="CHP02185_IM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09605">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02185">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="198" mass="21784" checksum="F6FB9BC719D4656D" modified="2018-10-10" version="1">MNTLKVRDLVNVGVFTVIYFIVTYATGMLGMFGPWMIPIAGAFALLLNGIVIMLYLSRVPKFGALTITGLLIGIVMSVGHSYWTIIMGILCGVIADLIQSKAGRAKTLEPRRGQLAYAVFSVWGVSPLIPVFYDADSYFSKIAESWSADYAADMRTIFQPWVIVVWAVVIFLIALIGAQLGIRSNRKHFERAGVIKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R483</accession>
    <name>A0A2Z5R483_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">RA11412_2070</name>
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    <organism evidence="3 5">
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        <lineage>
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    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88369">
        <property type="protein sequence ID" value="BAV88369"/>
        <property type="gene ID" value="RA11412_2070"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2070"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="403" mass="45600" checksum="93AEBFF049B5A532" modified="2018-10-10" version="1">MTVMLRNAIKLGGMVCRNFRKIFHVPRNEFSQRLCWIATLGVVAIVFIPPLASFLLNDFIGVRFEQGDGSKEIRTALLYMAGGLIALVTLNETHSKNEIERKKNNDDAENIREQIAVQKNQLNIQKNQLDFQQEQYKDSKIREVNLSFADAYTQLSSGSLTGQRLGANKILQVVDDWLNMGNKKQAQSVLNNIFEYIRKGAVGDGRVNNENYPFENVKWIVEAIKEYTIRSNQQNSTSLWSDLDFNFDGCIFNFDVDLSGIDIHGNLSFRNSTFAKSLDMSSSKIQTVNFYKASMEEGIFNKVNFMIADFVHTRIDKASFANAKFKSVIFQETKIGDKIETYSIPHVFGGAEISMTGRGNIFNFTEDSLEELSRLAPEELPPGARKGDCYMSCCGQSIPHKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4P9</accession>
    <name>A0A2Z5R4P9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88729">
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        <property type="gene ID" value="RA11412_2430"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2430"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="62" mass="7141" checksum="18AE8BC47B9AF537" modified="2018-10-10" version="1">MRKPSVKRMIKARTTGRAKRAVKKAVIPGYGKRGMGFVKNPKRSVKGAIYRRTTFSVWDLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVP5</accession>
    <name>A0A2Z5QVP5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86451">
        <property type="protein sequence ID" value="BAV86451"/>
        <property type="gene ID" value="RA11412_0152"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0152"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="40" mass="4197" checksum="252867896BDE33DC" modified="2018-10-10" version="1">MPLGAVGAKIDVAFGAPTVRMRREAFCGGASARVHRTLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVR6</accession>
    <name>A0A2Z5QVR6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_07500</name>
        <name evidence="6" type="ORF">RA11412_0177</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86476">
        <property type="protein sequence ID" value="BAV86476"/>
        <property type="gene ID" value="RA11412_0177"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0177"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="125"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="157"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="365" mass="37901" checksum="80811F61E079A3C2" modified="2018-10-10" version="1">MANEYPHEQTDNTTDKKPPHRDTSHREAASAPPNEPPLTGDQTPPNGPDTHNGSGPPEPTETTHAPAPGTPPQPAPEEHTAAYPQPHPGAAHANPAPNTGAPTPDMPPAQQGYGAYPPPVAGAVISARGLIKSYGPNTVLRGVSLDIYPGESVAIMGPSGSGKTTLLHVLSGIIKADAGTVHINTGTHNTAHAGAPTELSSLTEKQRTALRAGSFGFIFQQGLLVPELTTEENVALAAMLAGTPREQASMAATHLLSQLGLGTMLQRRIGELSGGQAQRVAIARSQVTGAPITFADEPTGALDTATAQEVMNLLLALIPQQGKTLVIVTHDPNIAAQCSRTIHLLDGQIVHDSQHPAQPRQEGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVR9</accession>
    <name>A0A2Z5QVR9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maltose O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86488">
        <property type="protein sequence ID" value="BAV86488"/>
        <property type="gene ID" value="RA11412_0189"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0189"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="101" mass="10384" checksum="453E510C1AEB60AE" modified="2018-10-10" version="1">MNPQDRKNLWEGGLPITVGDNVWIGGGAIILGGVSIGENAVIGAGSVVTKDVPANAVVVGNPARVVRTVGPDEHPAHPHQYSAQSIAEAQAFYDSLTASID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVY1</accession>
    <name>A0A2Z5QVY1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">purA</name>
        <name evidence="12" type="ORF">I6I94_07020</name>
        <name evidence="13" type="ORF">NCTC10207_02221</name>
        <name evidence="11" type="ORF">RA11412_0259</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023134432.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86558">
        <property type="protein sequence ID" value="BAV86558"/>
        <property type="gene ID" value="RA11412_0259"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0259"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="298"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="330"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="412"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV86558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT88295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VEI24716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="428" mass="46616" checksum="B37CF9D4136B08FC" modified="2018-10-10" version="1">MSAVVIVGAQWGDEGKGKATDLLGPRVDYVVKPNGGNNAGHTVVVNGQKFELKLLPAGILSENATPVIGNGVVVNPEALFAEIEGLQARGADTSKLKISANAHLVAPYHQTMDKVTERFLGKRAIGTTGRGIGPTYMDKVGRLGVRVQDILDESILRQKVEGALRQKNELLVKVYNRRHVEVNEIVDYFLSFAERLKPMIVDTTQLLNNALDEGKTLLMEGGQATFLDVDHGTYPFVTSSNPTAGGACVGSGVGPTRISRVIGIQKAYTTRVGAGPFPTELFDKMGEFLRTTGGEFGVNTGRPRRCGWYDAVLARQAVRINGFTDLFITKLDVLTGLEKIPVCVAYEVDGVRFDEVPMTQTDFHHAKPVYEYFDGWSENISDAKSLADLPENARKYVHKLEELSGCRISAIGVGPDRDQTIVVRDLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW00</accession>
    <name>A0A2Z5QW00_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_07010</name>
        <name evidence="8" type="ORF">RA11412_0263</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2Z5QW00"/>
    <dbReference type="EnsemblBacteria" id="BAV86562">
        <property type="protein sequence ID" value="BAV86562"/>
        <property type="gene ID" value="RA11412_0263"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0263"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07474">
        <property type="entry name" value="Peptidases_S8_subtilisin_Vpr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034213">
        <property type="entry name" value="S8_Vpr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="SLH" evidence="7">
        <location>
            <begin position="1107"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="7">
        <location>
            <begin position="1169"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="7">
        <location>
            <begin position="1234"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="1289" mass="136984" checksum="DD74274803F02A8B" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW55</accession>
    <name>A0A2Z5QW55_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86621">
        <property type="protein sequence ID" value="BAV86621"/>
        <property type="gene ID" value="RA11412_0322"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0322"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="166" mass="17670" checksum="9E950017E03881C6" modified="2018-10-10" version="1">MWGASTLYLLLGRVAHLGMDSNMYGLGMFISVLGAVAASAIIHKTPSLGAKAHPNTLLFLMCCAYCIAIIPGIISVFCALFISAGIIVIYNIRLYSDVQKNSNPKHIGKVMSVIFLATALFTALGSLLFSHVSVWADTGLYAIVCAASLIAVTAGLTLTKWTRRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW63</accession>
    <name>A0A2Z5QW63_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86626">
        <property type="protein sequence ID" value="BAV86626"/>
        <property type="gene ID" value="RA11412_0327"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0327"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="4719" checksum="56676A7C232ADD22" modified="2018-10-10" version="1">MSDIPASEPQFGAPPTVTQAPARLGTQGTLDLVKKRPAHPRQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWE3</accession>
    <name>A0A2Z5QWE3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Possible methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06470</name>
        <name evidence="2" type="ORF">RA11412_0401</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86700">
        <property type="protein sequence ID" value="BAV86700"/>
        <property type="gene ID" value="RA11412_0401"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0401"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="43"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="200" mass="21437" checksum="65E158EFFEBBB5EC" modified="2018-10-10" version="1">MTVSSRYGARAAEYCEALGSLDQMEPTDTALITSWSASVPGSILDAGCVPGHWARLLASADRPVTGIDVTPEFIAHARAASSAPNLSFEVMDMAHTPYADGSFAGILAWYSLIHTPPAHLTGALTEFYRLLIPGGGLLLGMFLGEHGLPFAHAVTTAYYVSVPEFSTLCEKAGFTVEEVHTRRAGRHRDHLAIVARKPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWE6</accession>
    <name>A0A2Z5QWE6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86745">
        <property type="protein sequence ID" value="BAV86745"/>
        <property type="gene ID" value="RA11412_0446"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0446"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="64" mass="6774" checksum="EC168040A710BF42" modified="2018-10-10" version="1">MGITAAEIIKRQPKTYTGVDLDPKAAEIVRGRIGDNPNYTVVNAGAQETGLPDASYDVVVGRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWF4</accession>
    <name>A0A2Z5QWF4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsR1</name>
        <name evidence="4" type="synonym">rpsR</name>
        <name evidence="7" type="ORF">I6I94_06240</name>
        <name evidence="8" type="ORF">NCTC10207_02410</name>
        <name evidence="6" type="ORF">RA11412_0456</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI25086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004005948.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86755">
        <property type="protein sequence ID" value="BAV86755"/>
        <property type="gene ID" value="RA11412_0456"/>
    </dbReference>
    <dbReference type="GeneID" id="29742406"/>
    <dbReference type="GeneID" id="61436031"/>
    <dbReference type="KEGG" id="raj:RA11412_0456"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI25086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="78" mass="8713" checksum="D6CEF361DBEAA990" modified="2018-10-10" version="1">MAKAEIRKPKPKQNPLKAADVTVIDYKDVALLRKFISDRGKIRARRVTGVTVQEQRKIAQAIKNAREVALLPYSGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWF7</accession>
    <name>A0A2Z5QWF7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_0265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86564">
        <property type="protein sequence ID" value="BAV86564"/>
        <property type="gene ID" value="RA11412_0265"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0265"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="19"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="7">
        <location>
            <begin position="301"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="497" mass="52000" checksum="08B4C66FAF8A05BB" modified="2018-10-10" version="1">MVDTKTVNTWTRENTGYTGKDVTIAVVDSGVDYTHSDFGGPGTAEAYQKAKDMPELPSADSGLIDRNKIAAGVDLVGDSYNASSTNTEQNTPHPDNNPLDCRPDGFGSGGHGTHVAGTAAGYGVNQDGTTFRGDYSKLTAEQLNQMKIGPGTAPEAKILPVRVFGCHGTTHMVIKALDTVMDPNGDGDFSDKANVVNLSLGGEFAPVDDPESYIVNTMARQGVFTVAAAGNANNYNGVGDTYSNSGSPANAAAGLSVANAYGTTQPTDQMKVLAPEQQAGFVNGVYTSSFGYAAASADKLTGEVVKAPASNRYGCEAFSEQDAAQLKGKWVYIDWEDPATGKFPCGSAVRFNHVEAAGGQGVILGSVQERHEVGIAGNATIPGFMLSQSATDKLATAINDGTLRVELNNDYKTQGRTSHSKALSLVSSSARGQHGSDGYIKPDVAAPGAEIVSAAVGGGTKGLRSRAPPWRHPTHPGWRHWCCRRIRTTPPPCSRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWH2</accession>
    <name>A0A2Z5QWH2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yidD</name>
        <name evidence="4" type="ORF">I6I94_06165</name>
        <name evidence="5" type="ORF">NCTC10207_02425</name>
        <name evidence="3" type="ORF">RA11412_0476</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI25114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887440.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86775">
        <property type="protein sequence ID" value="BAV86775"/>
        <property type="gene ID" value="RA11412_0476"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0476"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI25114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="141" mass="15626" checksum="E01DDF71816E7974" modified="2018-10-10" version="1">MSKNRRDERFHQHSSATHHAHSDPDALLHAAPHEFVRPVSVLHALYTLPQNIFIGLIKAYRKVISPLYGDVCRYYPTCSAYGLEAFTTHGAIGGLSLTVRRILRCTPWATGGIDPVPPGKRVFTPGEEPKIVLLNHPPTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWI4</accession>
    <name>A0A2Z5QWI4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86756">
        <property type="protein sequence ID" value="BAV86756"/>
        <property type="gene ID" value="RA11412_0457"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0457"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="3875" checksum="C4FBFCC22FFB968E" modified="2018-10-10" version="1">MIGVPQATTNPRSKPLAFSPNKTIHPSRGLLTAGSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWK1</accession>
    <name>A0A2Z5QWK1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
            <shortName evidence="6">RNase P protein</shortName>
            <shortName evidence="6">RNaseP protein</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rnpA</name>
        <name evidence="8" type="ORF">I6I94_06160</name>
        <name evidence="9" type="ORF">NCTC10207_02426</name>
        <name evidence="7" type="ORF">RA11412_0477</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI25116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037237180.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86776">
        <property type="protein sequence ID" value="BAV86776"/>
        <property type="gene ID" value="RA11412_0477"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0477"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV86776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VEI25116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="126" mass="13949" checksum="6DCF3480A54FDD35" modified="2018-10-10" version="1">MLPLQHRMRTGVQFSQTIRSGVRSGRRNIVLSAAKQNGETTRIGFIVSKAVGNAVVRNRVKRRLREAASDTVKTHPHGYYIAVRALPASKNATYQQLHHDYTQALTAALTKLAGEHKPRGAGQNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX80</accession>
    <name>A0A2Z5QX80_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent DNA helicase RecQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87055">
        <property type="protein sequence ID" value="BAV87055"/>
        <property type="gene ID" value="RA11412_0756"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0756"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="127" mass="13814" checksum="5B21C24115C4BDD1" modified="2018-10-10" version="1">MNVLAAWDWGDTGRPVAVLTVPSPVRPQLVRSLGEGLAGVGKLAYLGEAVLTDAPRFFGGNSAFRCADALRCYTLPDRVRDYLHEHQVPVLLVSELVDSRWTSTVLARELRRAGASAVYPFALAYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX85</accession>
    <name>A0A2Z5QX85_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86834">
        <property type="protein sequence ID" value="BAV86834"/>
        <property type="gene ID" value="RA11412_0535"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0535"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="85" mass="8919" checksum="2B7C7B2E895D53F7" modified="2018-10-10" version="1">MRTSPPDADGVALGETDDDEVASAGNLPGSGHFSGFSGIPWLLYELCELEADGCSGESSFFAENVVHELKTSINAAPAEMDARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXB1</accession>
    <name>A0A2Z5QXB1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0712</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87011">
        <property type="protein sequence ID" value="BAV87011"/>
        <property type="gene ID" value="RA11412_0712"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0712"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="204" mass="22019" checksum="CB85EAA2A40310EB" modified="2018-10-10" version="1">MGNVPNTNQSHHAPGMDALAHTAVLALGSNLGESETTLEQAAADLVHLSGGAVRLVGASGLYVTEPVGGPADQPDYINAILEVRTSLDPYALLVLCQQVEAHHHRVRLVRWGPRTLDIDVITYDDLVSDDPVLTLPHPRAHERAFVLVPWEQANPQAQLMVRTASGWANRAVAELAREVSAADSHANVNAVKLLRPMNFMPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXH0</accession>
    <name>A0A2Z5QXH0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87071">
        <property type="protein sequence ID" value="BAV87071"/>
        <property type="gene ID" value="RA11412_0772"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0772"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="4768" checksum="0DEA9EB733E6683F" modified="2018-10-10" version="1">MKTCFLACRARGSESAVPMCAGRTRPFSLYAEDARVDITTQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXI1</accession>
    <name>A0A2Z5QXI1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA helicase RecQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87053">
        <property type="protein sequence ID" value="BAV87053"/>
        <property type="gene ID" value="RA11412_0754"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0754"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="42"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="157" mass="17119" checksum="E992A810B9680201" modified="2018-10-10" version="1">MNSNHLASPQAQPLPTRARTLLAALTNNPHAAFHTGQYQAIEALVAHRRRVLVVQRTGWGKSAVYFIAALLLREQGAGPALIISPLLALMRDQVAAAERAGVRAAMLNSSNVTDWDDIHTRLESDQIDVLLISPERLNNPAFRDEWLPQLAPASGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXJ0</accession>
    <name>A0A2Z5QXJ0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Recombination protein RecR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0853</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87152">
        <property type="protein sequence ID" value="BAV87152"/>
        <property type="gene ID" value="RA11412_0853"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0853"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="217" mass="23558" checksum="87F95721EDBD9895" modified="2018-10-10" version="1">MDPNLEGEATATYLSRMLVPLGIRLSRLASGLPVGGDLEYADEITLGRALEGRRVISEGAGIAQANAAEDFEQVVEEEQAERERAAAEPKAPRKRWSGSMFDDLDNTQDGAGPSNPEDADEQQGENNNSLSAAPPSHGEQATVNEALIEQVLQDSAENHAPKPEGGTSEIPVETTRADAYRSADYEERIRKIQEEPLRTPTPQVPPLPGTKYVNPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXP2</accession>
    <name>A0A2Z5QXP2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antitoxin VbhA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05235</name>
        <name evidence="2" type="ORF">RA11412_0705</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87004">
        <property type="protein sequence ID" value="BAV87004"/>
        <property type="gene ID" value="RA11412_0705"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0705"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041535">
        <property type="entry name" value="VbhA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18495">
        <property type="entry name" value="VbhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VbhA" evidence="1">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="84" mass="9821" checksum="A9D813A2C14F7ED0" modified="2018-10-10" version="1">MSQSDMFDLDKRWPDLFDRLDPAQRRSVIQTLASSWLEGRRPDRQEVENLVDEACGAISEEEYLRRALEKARGLEPENKVEKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXP6</accession>
    <name>A0A2Z5QXP6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87141">
        <property type="protein sequence ID" value="BAV87141"/>
        <property type="gene ID" value="RA11412_0842"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0842"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="3869" checksum="60CA8D408439CD9F" modified="2018-10-10" version="1">MVVVSANATGVETILPRPTTALAKNAQERLALGETDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXQ5</accession>
    <name>A0A2Z5QXQ5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Ferredoxin-NADP(+) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I6I94_04790</name>
        <name evidence="10" type="ORF">RA11412_0807</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87106">
        <property type="protein sequence ID" value="BAV87106"/>
        <property type="gene ID" value="RA11412_0807"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0807"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="9">
        <location>
            <begin position="9"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="203"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="376"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="467" mass="51742" checksum="0264CA88E7B4D198" modified="2018-10-10" version="1">MSEATRPLRVAVIGAGPAGIYAADLITKSEEVRSGAVEVSIDIFDRYPAPFGLIRYGVAPDHPRIKGIITALHKVLDRGDIRFFGNVEYGKDLNLADLREHYDAIIFATGAIHDAPLPIKGIDLDGSYGAADFVSWYDGHPDYPRTWPLNAKEIAVLGNGNVALDIARVLSKHADDLLVTEIPENVYEGLKSSPVTDVHVFGRRGPAQIKFTPLELRELSHSRDVDIVLYEEDFEFDEASDEAIQTNNQVKTMMKTLTTWLTDQEEGEQTASRRLHLHFLQSPHEILGEDGKVVGIRMERNKLDGKGGIEGTGEFVDYPVQAVYRAIGYFGSELPEVGYDADKGVITNVEGRVVDENGEHVPGLYATGWIKRGPVGLIGSTKGDALETITHLLEDRENLYTAAEPDAETFSDYLDSKGIRYTTWEGWHRLDDHEKALGAASQDAKGESRERVKVVDRDEMIRISRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXS5</accession>
    <name>A0A2Z5QXS5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_05100</name>
        <name evidence="3" type="ORF">RA11412_0735</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87034">
        <property type="protein sequence ID" value="BAV87034"/>
        <property type="gene ID" value="RA11412_0735"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0735"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="283"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="331" mass="37521" checksum="FB55F50FB2E9764B" modified="2018-10-10" version="1">MTPTVAIIVRTKNRPQFLTRALANIAEQTYQDYAVYVVNDGGDRAEAERIVTASPVADKTTLLHTDGIGMEAASNLGVRESESTYVTVHDDDDLWAPKFLKHTVAALDSTGANMCTVRIVERFERETDNGFQVLNERIFHEGLPIVGLQFLYRTNRAVPIGVIYRRDLHTRLGGYRDDLAVVGDWEFNMRAAAEGEIITIDEPLAYWCQRPEATGAAANSVSREAEHRYYDSKVRAEEIRKDIASGSSAGPYLYQAHLANELDGRILENHNLLRDVLATLGRIETTQREQGEQLKRIEAAQQEQNERLLRVERALSWRERAERITKYFKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXV6</accession>
    <name>A0A2Z5QXV6_9MICC</name>
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        <recommendedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase C</fullName>
        </recommendedName>
        <alternativeName>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I6I94_04965</name>
        <name evidence="11" type="ORF">NCTC10207_00246</name>
        <name evidence="9" type="ORF">RA11412_0765</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
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    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023133587.1">
        <property type="nucleotide sequence ID" value="NZ_JPVS01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87064">
        <property type="protein sequence ID" value="BAV87064"/>
        <property type="gene ID" value="RA11412_0765"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0765"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="7">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VEI22178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="193" mass="21558" checksum="9D1381D28CA02943" modified="2018-10-10" version="1">MAVLSIGDQFPAYELTGVVPGKLAEIEANKPEDYFTTVSSEGLDEDTWRVVFFWPKDFTFVCPTEIAAFGKLADEFEARDCQVIGVSVDNEYTHYAWRRSHEELVDLPIVMASDLKRELTSALGILNKDGVADRATFIIDPHNTIQSVSITADSVGRNTDEVLRQLDALQSDELCACNWKKGAETIDAFKEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXW4</accession>
    <name>A0A2Z5QXW4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87282">
        <property type="protein sequence ID" value="BAV87282"/>
        <property type="gene ID" value="RA11412_0983"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0983"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="185" mass="18612" checksum="6CB88F6BF392FEB0" modified="2018-10-10" version="1">MCFAFGALFSYISGSTFVLQKILGLDAGQYTLAFGVNSLGIVAMSSLATALVGKVAQRTIVNVGVSALLVVSVLLTGSFLIGISLWPTLVLLFCLTCSVGLVFGNASALALNEARHMAGSASAVMGTIQALLGGVAAPLVSLGGEGAYLPMAFSILGFAVLTGITLFSTPRKDSDYAADGGAGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXY5</accession>
    <name>A0A2Z5QXY5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PE-PGRS virulence associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87221">
        <property type="protein sequence ID" value="BAV87221"/>
        <property type="gene ID" value="RA11412_0922"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0922"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="380" mass="37484" checksum="53D16FD9FCBA83EE" modified="2018-10-10" version="1">MRFDLLGGVGGTLIAPYSEFTGPNRTGGTGGGGGYIKGTVKVTPGQRIKFYVGTSGVGYYDRPAKGGEGYGNGGSSAALPTELGSDVQGKLNSHSNKVTVYSGSGGGSSAIVMVDAQTSQETVLAVAGGGGGAGARGFTHATQEGGTWITDDPTFYESPNLHIGRGGSAGDDYVPEGLGFSGQERYHQHYDAEVLIPSGSNGSSAIGGSGGALATVTGDKELIFDSTARTEIRTGNSAGKSGGSGPNGNGADGVVAYGYALSTVGNTSDDRNATGYIVSGGGGAGYGGGGSGSAVAVASESLKSDTAFVGVASGGGGGGGNFVSPDVIDPYITAEGGSSVVVGSTTDGMIRYSFCPSDPNKQPDPEPTSPEDPEWMARNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY11</accession>
    <name>A0A2Z5QY11_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroQ</name>
        <name evidence="11" type="ORF">RA11412_0901</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87200">
        <property type="protein sequence ID" value="BAV87200"/>
        <property type="gene ID" value="RA11412_0901"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0901"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="121"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV87200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="167" mass="18701" checksum="6D10221AE057EF5B" modified="2018-10-10" version="1">MVWWACILRGDASMCHTKSMSATIFVLNGPNLNLLGHRRPEIYGHTTLVDIELSVRERAALHGFDVEFMQTNYEGKLVDEIQRARTRGAAIVINPAAYTHTSVALHDALEAAELPVVEVHLSNIYRREEFRHHSYVSPQATTVISGAGAYGYVMAIDFIAEYLKDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY19</accession>
    <name>A0A2Z5QY19_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87226">
        <property type="protein sequence ID" value="BAV87226"/>
        <property type="gene ID" value="RA11412_0927"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0927"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="42" mass="4757" checksum="7EC913A8C14B747B" modified="2018-10-10" version="1">MTDLSYGQEYFCIPLRGGPHDLLYMLRTACCAPWAGRSLTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY28</accession>
    <name>A0A2Z5QY28_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1524 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_03865</name>
        <name evidence="3" type="ORF">RA11412_1043</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87342">
        <property type="protein sequence ID" value="BAV87342"/>
        <property type="gene ID" value="RA11412_1043"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1043"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008613">
        <property type="entry name" value="Excalibur_Ca-bd_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05901">
        <property type="entry name" value="Excalibur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00894">
        <property type="entry name" value="Excalibur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Excalibur" evidence="2">
        <location>
            <begin position="297"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="338" mass="36214" checksum="A2029EDCAAA8C8C7" modified="2018-10-10" version="1">MEGPTASSASPTAASTHNQLSSPSSTPYVSPAAAFETQEEDAEEQTHDTGISPEQETNPVTALPAANVSDAASALTTLQSLPVKGRAPKTGYSRDQFGHAWTDTDRNGCDTRNDILRRDLYEVTVKPGTRACTVLSGTLEDPYTGVSIHFRRGKDTSRAVQIDHVVALSDAWQTGAQELSKQQRIELANDPDNLLAVDGAANQQKSDADAATWLPANKAYRCIYVEKQVRIKAKYGLWVKAAEKEAMVRMLNDCVSSENSGTIEHTPVASPITEPTRGTPQARVQAPTQEPDSAGTYYKTCAEAQAAGAAPIRRGQPGYRAALDRDGDGVACEVTTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY91</accession>
    <name>A0A2Z5QY91_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87428">
        <property type="protein sequence ID" value="BAV87428"/>
        <property type="gene ID" value="RA11412_1129"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1129"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="4752" checksum="16C5AFAB05529217" modified="2018-10-10" version="1">MVRTGACSANSALDFSKLIAAGFTPRDHRDALAEYLSHITYPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYD0</accession>
    <name>A0A2Z5QYD0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septum formation protein Maf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87462">
        <property type="protein sequence ID" value="BAV87462"/>
        <property type="gene ID" value="RA11412_1163"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1163"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="172" mass="18431" checksum="BBAD833D364ABB48" modified="2018-10-10" version="1">MVGMTSAPLDASAAKACTPRLVLASASPARKKLLEDSGIVFEVRVSHVDEDAVLVRATKTDGDQHTPAQAAQLLAQAKARAVAHELEDEGVVDALVLGCDSVFEFEGTAYGKPYTPQKARERITAMSGKMGTLHTGHYLVDLRPAPEDADPCEACMIPTNLSFAAHEYILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYP7</accession>
    <name>A0A2Z5QYP7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4245 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_03780</name>
        <name evidence="3" type="ORF">RA11412_1065</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87364">
        <property type="protein sequence ID" value="BAV87364"/>
        <property type="gene ID" value="RA11412_1065"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1065"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025339">
        <property type="entry name" value="DUF4245"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14030">
        <property type="entry name" value="DUF4245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="258" mass="27858" checksum="3BB0D710F9899A3D" modified="2018-10-10" version="1">MENSQNNAHNPQDENPPAGTRKLGDASSSSSAAELPQDLTAAERPDGEQTVTPQITVKQSKRINAPARNMIISMVAMILILIPVLWLMPRPDKTPYRPQVNVAQVAFESSRQAGFPVAVPQLEGWHYNYARWNGNTPDNIGFFKSGQVTGKNHFIELTQAKDTNPTWVAQQTDNATKQGTEQIAGVEWEVRAATSKKNNERVYSYVAHVPSAGGQSTTIILSGAADPAEFSQLADAASAYLKNPTATADPSGTGSTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYS4</accession>
    <name>A0A2Z5QYS4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyguanosinetriphosphate triphosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03255</name>
        <name evidence="2" type="ORF">RA11412_1207</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87506">
        <property type="protein sequence ID" value="BAV87506"/>
        <property type="gene ID" value="RA11412_1207"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1207"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020779">
        <property type="entry name" value="dNTPase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF32">
        <property type="entry name" value="PTHR11373:SF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="75"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="453" mass="51325" checksum="14D3EAFC75BA79EA" modified="2018-10-10" version="1">MTRLAEEGQERWEWNLPAGYTPDDSERWVPEIHPFQDRTPFERDRARVLHSSALRRLGAKTQVMNPDTDDFVRTRLTHSLEVAQVGREVGRMLGCDPDVVDTACLSHDLGHPPFGHNGERALNKIAAHMGGFEGNAQTLRLLSRLEPKVIAEHDVSAGLNLTRASLDATCKYPWTRTDAPRRADGTQTHKFGVYEDDLPVFEWFREGAHDAGVEPQRKCLEAQVMDLADDISYSVHDVEDAVFGGHVQLEQLREAKHRQAVFDMTRQWYLPAATDEQLDAALSRLETLNRWVPCMTGSRASLAQFKGLTSKLIGRFAWSAVEATRERYGRDTPLTRYSAELIVPEDTRDEIAVMKGIATAFVMTVRDAQPHYEHQHEILGILVEALYEDSQRANPQYIDSIFRTDYAQLGAHDDDARLRLVIDQVASLTDRSAVALYKRINGTPWMLGEKPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYZ4</accession>
    <name>A0A2Z5QYZ4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rsmH</name>
        <name evidence="9" type="ORF">I6I94_02510</name>
        <name evidence="8" type="ORF">RA11412_1389</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87688">
        <property type="protein sequence ID" value="BAV87688"/>
        <property type="gene ID" value="RA11412_1389"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1389"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="71"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="350" mass="38160" checksum="2B8F83B5EE556DF9" modified="2018-10-10" version="1">MSAKESTHAGAQGAVAPAHTLTLTETPDAGLSKKEAKERHVPVMLTRCLDLLAPALEREGAVVIDGTLGMGGHTEAMLERFPELQVIGIDRDPQAHTIAGQRLERFGERFIPVHAVYDQIEYAMDVAGVNAVDGVLFDLGVSSMQLDERSRGFAYSYDAPLDMRMNSEDELTARTVVNEYPLERLQRIIRTWGEEKFAARIAERIVAQRAVQPFETTGELVAAIQKAVPAAAQRKGGHPAKRTFQALRIEVNHELEALERAVPVAIDSLSLGGRFVAMSYHSLEDKIVKRGLSAAATSKAPKGFPVELDEHKPTMKVITRGAEPPTEAEIAENSRAASAKLRAGEKIRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ05</accession>
    <name>A0A2Z5QZ05_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87530">
        <property type="protein sequence ID" value="BAV87530"/>
        <property type="gene ID" value="RA11412_1231"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1231"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="129" mass="13805" checksum="E85B13E8B0465312" modified="2018-10-10" version="1">MNVWELAENVTKGLEGMKVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVIKTVPEDQIVETLIEEANRIAAEMEARGEYVPREPPPPSPSNSFQRPAPVCGAFRPLAAQHLTTFGRHSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ42</accession>
    <name>A0A2Z5QZ42_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polyphenol oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I6I94_02450</name>
        <name evidence="9" type="ORF">RA11412_1408</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037235661.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87707">
        <property type="protein sequence ID" value="BAV87707"/>
        <property type="gene ID" value="RA11412_1408"/>
    </dbReference>
    <dbReference type="GeneID" id="32323193"/>
    <dbReference type="KEGG" id="raj:RA11412_1408"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="PTHR30616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="286" mass="30549" checksum="FAE124209F40291E" modified="2018-10-10" version="1">MDNTEHIYHTSAPLLFSYQLFRSGAHEVNIAFTSVAAGNVGLHVDTGEPQAQTLRHRLRLEGMLSTGLPFLYLNQVHGTTVVCAEDYEPAQYAPQDSADGFSDTHAQHLLEQAPVADAAYSTNGRPLAIMVADCIPVVLVGQRQDGELVLAVAHAGRKGLLDGVLQRTVVAMHEAGAENICAWLGPSICGSCYEVPEQMRTASAERIPQVAAQTRTGTPALDLPAGAIAILEDMGVEVSTELAACTYETGELYSHRAFTHGSRPAGRIAGLVWLSAASEEKEETTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ83</accession>
    <name>A0A2Z5QZ83_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_02925</name>
        <name evidence="4" type="ORF">NCTC10207_00693</name>
        <name evidence="2" type="ORF">RA11412_1291</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87590">
        <property type="protein sequence ID" value="BAV87590"/>
        <property type="gene ID" value="RA11412_1291"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1291"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI22612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="57" mass="6137" checksum="46D596D4E662B8A6" modified="2018-10-10" version="1">MNPMYSGLILMTVGAFFAGGGISFRKQKLPLVAQVIMWLIALALFGYGAYVAFTFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ84</accession>
    <name>A0A2Z5QZ84_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_02570</name>
        <name evidence="3" type="ORF">RA11412_1374</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87673">
        <property type="protein sequence ID" value="BAV87673"/>
        <property type="gene ID" value="RA11412_1374"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1374"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="2">
        <location>
            <begin position="47"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="106" mass="11531" checksum="D284A9ED9022FCCD" modified="2018-10-10" version="1">MKEPQKVKDFFMPQNSNSPQRPNEHTLHSNQDDLGPTIVCAPFAGYLTLLVGQGEHVDAGQKLAIVEALKVETLVTARTHGRVGRITHTDGSYVTGGQLLLTIVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZA5</accession>
    <name>A0A2Z5QZA5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87554">
        <property type="protein sequence ID" value="BAV87554"/>
        <property type="gene ID" value="RA11412_1255"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1255"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="147" mass="17278" checksum="E3A6E943DF4BF2BF" modified="2018-10-10" version="1">MFTIVVPPDYAEELQQICTLDASQREKLISLLALAWLDWKRQHLSALEVAEDIVRIVREQEIFSHPERLQQWAEHMDEMYLEELDADKPYDIVQPLFYRARFAASLSYAQDALTEDKSLDYLLYEYSFSQETGTDHLMLHALHTVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZA8</accession>
    <name>A0A2Z5QZA8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87777">
        <property type="protein sequence ID" value="BAV87777"/>
        <property type="gene ID" value="RA11412_1478"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1478"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="71" mass="7987" checksum="DE41B73BFB9043E1" modified="2018-10-10" version="1">MLTGCEEGTILNVRNPQMSDTATVKILVGGQLSLFTEHELVTQEQAFECAVQYFKTGRISHVGLPYTWERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZD1</accession>
    <name>A0A2Z5QZD1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease PH</fullName>
            <shortName evidence="4">RNase PH</shortName>
            <ecNumber evidence="4">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">rph</name>
        <name evidence="8" type="ORF">I6I94_02025</name>
        <name evidence="7" type="ORF">RA11412_1509</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888939.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87808">
        <property type="protein sequence ID" value="BAV87808"/>
        <property type="gene ID" value="RA11412_1509"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1509"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
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            <begin position="14"/>
            <end position="144"/>
        </location>
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        <location>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:43474"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="245" mass="25913" checksum="8785BE37DAC368AC" modified="2018-10-10" version="1">MSENTREDGRACNELRPITITRGWSLNAEGSALIEFGNTRVLCTASFTEGVPRWLKGEGKGWVSAEYAMLPRATGTRSSRESVKGKIGGRTHEISRLIGRSLRAVIDMDALGENTIVLDCDVLQADGGTRTASITGAYVALADAIGWAKKNGLIASGANPLTDSVSAISVGIIDGTPMLDLPYTEDVRAETDMNVVVTGSGKFVEVQGTAEGAPFDRDELNALLDLALEGTAELAQIQREVLGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZF4</accession>
    <name>A0A2Z5QZF4_9MICC</name>
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        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Rothia aeria</name>
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        <lineage>
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            <taxon>Actinobacteria</taxon>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </source>
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        </source>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="906" mass="95657" checksum="EB5D0A4289C3D569" modified="2018-10-10" version="1"> </sequence>
</entry>
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    <protein>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF20148"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="BAV87945.1"/>
        </source>
    </evidence>
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    </evidence>
    <sequence length="306" mass="34286" checksum="DA28DD97E91FC32C" modified="2018-10-10" version="1">MAFNKIARKSSDFNVVFTLPDFCWPPPPAPPVTPPIPFPLFADLGSAKTVAKDVRLNRKPAFVFNASKTNRTTGDEPALPGRKGVLSRTATKPAWPMMHSSSVKIRKRYIIRAGDMFHMNNKFKKNCRPNPVFPVRPLPLVWNRSYYSDQDGTGWLGEGWSVPGCQRIIRDAAGLAYIDDQGRLFPLPEVDEDDEEPVLFESEQIWFSKNPDGHYVIASLDGSIALRFAPLVIAEDGSDEDSTLFPLVAVEDANGNHQRFVYHPLTGLPQYVIDGNGWVFSLNFGNVADEQYHYDDNKRVDQTGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZQ8</accession>
    <name>A0A2Z5QZQ8_9MICC</name>
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        <recommendedName>
            <fullName evidence="2">HisKA_3 domain-containing protein</fullName>
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        <lineage>
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    <reference evidence="3 4" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87846">
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        <property type="project" value="UniProtKB-KW"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="325" mass="36362" checksum="0F97E1E6A4638401" modified="2018-10-10" version="1">MGNAAAVLSIQMLTLLICLGTADRDAGVAFITAGVTTTSLYYRYRNPYGSIYVFTVALLLSLFAPTVVIYSYLPVLLAAYHTGRHWNQKGRARAFIGGWVISFLVGVRSFIALLHSLSPNEPVLNAAGAAFIALFALFFCGLTFSFFWFFGASRRMRVLLQDEIRERAMRLEFEQQQERRLAAQDERTRIAREMHDIVAHSLSSIITQADGARYASAAARQASEEATDADGSQPETSQKIAEQTLDTIATTARGSLAQMRSLLGILRTDEVTMYTPPPAWVRCRCWWSRHAIRGFQSSSRVLAGCREAPCRRGLSWQRTGWCRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZR1</accession>
    <name>A0A2Z5QZR1_9MICC</name>
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        <submittedName>
            <fullName evidence="7">Proton/glutamate symport protein</fullName>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="subcellular location">
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    <dbReference type="EMBL" id="AP017895">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Na-dicarboxylate_symporter"/>
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        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="90" mass="9206" checksum="31A10FCA5F699DAE" modified="2018-10-10" version="1">MKVLQKIPLLAWIVIAILGGVLIGSLTPGLISGINSAAKISIPTDVVVQIFVSFSTIFSAFLSFAIPLIIIGFIVPGIGSLAQGAGKMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZS3</accession>
    <name>A0A2Z5QZS3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TsaC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87760">
        <property type="protein sequence ID" value="BAV87760"/>
        <property type="gene ID" value="RA11412_1461"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1461"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="2">
        <location>
            <begin position="15"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="265" mass="28388" checksum="665C1574BDAAF28B" modified="2018-10-10" version="1">MKAKLYPVSSETEVSEAITAAREALNSHETIVIPTDTVYGIACDAFSHEGVAKLLSDKGRSRTMPPPVMIFDQASLSGVADEIPDEVYELGRKFWPGALTVILYSYPSLNWDLGDTQGTVAVRVPNDEFALKLLTEHGPLAVSSANKTGQQAAVNAQQAADQLGENVSLIVDAGDRPASAGSTKESTAASDSKSQAPDTDAPGSEDTETADSVAESAPAAETTKDTPPKRRKVPEVMTHRHRLCLQQSWTAPAPRLWWCVRALFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZT4</accession>
    <name>A0A2Z5QZT4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87982">
        <property type="protein sequence ID" value="BAV87982"/>
        <property type="gene ID" value="RA11412_1683"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1683"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="396" mass="43990" checksum="57D2CC6E6F03E972" modified="2018-10-10" version="1">MGDFRSLYGSVGFSFEGRLTTLTDRARKLAMTAIYGAIESKMTMGETIFLRGDLTGLSTIDSPDTLTTKDVKGVIRLARAYDYTVHLVDAHHKNSPNPTDTNSAFDGVWEQKPDRKIMRGWVNMHDIAQILTVTPHDLSEYERIVLVGDIQGAGDELQELIAKVPGGLDSPHNFWIFVGDLFDRGTTPVTVYNTLLPERKNVVIVQGNHEIAVRRASLGTFNYDKPDDTIETLRQLEEAGITKRAVREELINRSVPFFAFTVGAREHWVSHGGVIPAVLDAVTAAPGRYVTGLLADEVLCRGTNNTERALYGKTNYRVFADELDTACARRGIVQWFGHRHEKRMEGMSPLDFEAIRPLESGVEHRGGFLTAVMLSNNGAVETLIRVPSTSTVKPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZY2</accession>
    <name>A0A2Z5QZY2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4253 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88065">
        <property type="protein sequence ID" value="BAV88065"/>
        <property type="gene ID" value="RA11412_1766"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1766"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025349">
        <property type="entry name" value="DUF4253"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14062">
        <property type="entry name" value="DUF4253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4253" evidence="1">
        <location>
            <begin position="10"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="117" mass="13161" checksum="2E061D62ED00EDC1" modified="2018-10-10" version="1">MAQPGSLIVIAKIPAQHPADIPAYLPTGGWNNCPSTDTQLAIAHYWYEKYGAYIAAVGGDKELEFNVTRPSTNPEATKRLAAEQYIFCPELVGPICSSFEELAQGIYCNRQWYFWWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R034</accession>
    <name>A0A2Z5R034_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88125">
        <property type="protein sequence ID" value="BAV88125"/>
        <property type="gene ID" value="RA11412_1826"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1826"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="193" mass="20708" checksum="69053D6C2D57C4D8" modified="2018-10-10" version="1">MGALARELRVAPSSLYNHFQSRDEVLGAVSDAVVSEIRVDSLREAIVVLAERELTVQAKTELWVSAFGAWGVSYRDAFSESAELVAALALTPVGWAPQTLRMYELVLEALAAFGCPQERALSVVEALEAFLLGAALDANAPDHVFDPAVAGGDYPRLQEAYRMLRGGAVAPAEDAFVVGLEAMLYGLARRVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R058</accession>
    <name>A0A2Z5R058_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydroorotate dehydrogenase (quinone)</fullName>
            <ecNumber evidence="11">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DHOdehase</fullName>
            <shortName evidence="11">DHOD</shortName>
            <shortName evidence="11">DHODase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pyrD</name>
        <name evidence="13" type="ORF">RA11412_1799</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(S)-dihydroorotate + a quinone = a quinol + orotate</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Cell membrane</location>
            <topology evidence="3 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="11"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88098">
        <property type="protein sequence ID" value="BAV88098"/>
        <property type="gene ID" value="RA11412_1799"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1799"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="12">
        <location>
            <begin position="50"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="116"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="336"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV88098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="381" mass="40791" checksum="348002A7EA84C59E" modified="2018-10-10" version="1">MRLYPTFFKLFFASMDPEKAHHIGLWGIQTLKNTGITRVLKHYLQPHPDLQTTAMGLTFPSPFGIAAGFDKGGKAIPALAALGFGHIEIGTVTAQAQPGNPQPRLFRLIEDKAVINRMGFNNDGAAAVGPRVAAARADLETEYPAQTRPLIGVNIGKTKTVELDNAIDDYLISTRTLAPQADYLAVNVSSPNTPGLRTLQSIEALRPLLQSVREEADRVSPHRHIPLTVKIAPDLADEDIIAVAQLAQELQLDGIIATNTTIARDGLGLRSPKTKINTIGAGGLSGEPLKTRSLEVLRLLKQELGDTITIISVGGVTTARDVQDRLNAGANLVQGYTAFLYEGPSGQPTLIADFSNSAAKTPKLIHKRLPPSPAGASHIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0A2</accession>
    <name>A0A2Z5R0A2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 21" type="primary">uvrB</name>
        <name evidence="21" type="ORF">I6I94_01340</name>
        <name evidence="20" type="ORF">RA11412_1672</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 23">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87971">
        <property type="protein sequence ID" value="BAV87971"/>
        <property type="gene ID" value="RA11412_1672"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1672"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="35"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="438"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="17">
        <location>
            <begin position="678"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="623"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="674"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="BAV87971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QQT89312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="723" mass="81930" checksum="8B686A02C7519BEB" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0C4</accession>
    <name>A0A2Z5R0C4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helicase PriA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_1869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88168">
        <property type="protein sequence ID" value="BAV88168"/>
        <property type="gene ID" value="RA11412_1869"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1869"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PriA_3primeBD" evidence="5">
        <location>
            <begin position="69"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="272" mass="30393" checksum="979A044BEE344468" modified="2018-10-10" version="1">MPYPADERLNATSGAREQQSLQQPDLLQGFPAIADALYASAPKPPQDPHEALAASGVPFPVARVRVDSTLPHLDRVFDYRVPEKMSEDAVPGARVRVHFNGQRVSGFITERAESTDYPQRLLPLLAVLSRVPVVAPEVFELAEALADRYASTVANVLRLAVAPRIAALDKRYEGHLPGFSELAGLGNGEPAGRTPRIRIIMQMVLKKRPTHPRRRVAPMLPRLRRCVRFCWAGSPRLLRIRPGCVIRRLLTTMRTARSLWPIWRMGSQHARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0F1</accession>
    <name>A0A2Z5R0F1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome C oxidase polypeptide I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88103">
        <property type="protein sequence ID" value="BAV88103"/>
        <property type="gene ID" value="RA11412_1804"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1804"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="42" mass="4819" checksum="A6ACE49A84225F27" modified="2018-10-10" version="1">MVPKSKGRIFVNWITSTDHKTIGYMYLIAAFISSAWAAPWRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0H0</accession>
    <name>A0A2Z5R0H0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_00260</name>
        <name evidence="1" type="ORF">RA11412_1966</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88265">
        <property type="protein sequence ID" value="BAV88265"/>
        <property type="gene ID" value="RA11412_1966"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1966"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="237" mass="25241" checksum="6708886A5A3EA2BD" modified="2018-10-10" version="1">MSTEPDLHAIGIDESVTETRERLAGRNVPVIDNPAGASWGVYTDPSGAKVAFGRAEDGTEYTDANLESPHAYPAQGYRVSHNLAHFDLLEGGDREGRFLAYVDNPTALTLTEPNKVTVRPAALGAEVVVYASEDEYQQAQSEHDGLTLDAKHLKSPWLLALHSGDATGDEASSVAMFAAVVQSAQLRTNELTGREFWYVLGESVVPMAIALPAETAQNLHPGAVIAGAFIIVASVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0L6</accession>
    <name>A0A2Z5R0L6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-[acyl-carrier-protein] reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glucose 1-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.47</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_00975</name>
        <name evidence="3" type="ORF">NCTC10207_01112</name>
        <name evidence="1" type="ORF">RA11412_1781</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.47" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887106.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88080">
        <property type="protein sequence ID" value="BAV88080"/>
        <property type="gene ID" value="RA11412_1781"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1781"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI23016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="247" mass="25964" checksum="4845890B93E822BC" modified="2018-10-10" version="1">MAQLTGKTVIVTGSSRGVGADTAQILAAEGANVVVNYRSKAPRAAKIVTSIEEAGGKAIAVQADVTNTADLQNLVQTAVDTYGSLDYLVLNASGGMESGMGEDYAMRLNRDAQLELARLAAQKMPAGGRIVFVTSHQAHFIREVQTMAEYQPVAESKRAGEDALVAEIPALAQKGISLVIVSADMIEGTVTATLLNRLHPGAIEARRETAGKLYTVNEFAHEVAKMVTAEVESGHVELVGGARGFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0N8</accession>
    <name>A0A2Z5R0N8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metal-dependent hydrolase YbeY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_1943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88242">
        <property type="protein sequence ID" value="BAV88242"/>
        <property type="gene ID" value="RA11412_1943"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1943"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="137" mass="15122" checksum="4A910D2C1B2D5AA1" modified="2018-10-10" version="1">MAELEFEIEEPDTGTEPEADALVRESFAAVDTAVLTRLVEHAFNRMRVSQSTYLSIAIVNEREMERIHLEWMDLPGPTDVMSFPMDELTPGTDTEPATGMLGDIVLCPRWPHVKAPRPGTQPLMNCACSPCTGSCTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0S7</accession>
    <name>A0A2Z5R0S7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose 5-phosphate isomerase B</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="5">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_11255</name>
        <name evidence="4" type="ORF">RA11412_2048</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887994.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88347">
        <property type="protein sequence ID" value="BAV88347"/>
        <property type="gene ID" value="RA11412_2048"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2048"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="71"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="162" mass="17563" checksum="54E471D40AEB44D2" modified="2018-10-10" version="1">MRVHIATDHAGLQLSHYLIEKLTAAGYEMIDHGPTEYDPLDDYPSFCINAALAVKRDRDAGLDSLGIVLGGSGNGEQMAANKVEGIRAALAWNHTTAALARDHNNAQVVAVGGRQHSPDEALEIIKVFLSTPWSGEERHARRIGQLGEYEQTGKIAGKHIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0T9</accession>
    <name>A0A2Z5R0T9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88160">
        <property type="protein sequence ID" value="BAV88160"/>
        <property type="gene ID" value="RA11412_1861"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1861"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="95"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="361" mass="39455" checksum="C466334BA8340203" modified="2018-10-10" version="1">MPLRLGFQKMGAGGGGVFVLFSTYTATSRRMKGIPVFFRPEGFSVTTPATVLEGVPGPLIPGTCHEAVLAGVRTRYWQYGLGMNTGVFYSKDFPKVLMVHGFRGDHHGLEIIANRLLALMPGADVISPDLPGFGRSDELSGQVSIESYVQWLHALIERVASGQKVLLVGHSFGSIVAAAYAAAHPETLDRLCLINPISEPALEGKHQAGPALASFYYWVGASLPERMGYALLRSQLITRATSEVMMRSKDPLMRRFINGQHAAYFGSFASRRGVLEAYRVSISKTAAQYAPQIRVPVQMLVAEDDDLGTVETADAMFEALEGRPQSPGQRFDLIPEVGHLIHYETPTLAARLIADFVREEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0V6</accession>
    <name>A0A2Z5R0V6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasmic axial filament protein CafA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88302">
        <property type="protein sequence ID" value="BAV88302"/>
        <property type="gene ID" value="RA11412_2003"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2003"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="116" mass="11256" checksum="DC36C89444C5158D" modified="2018-10-10" version="1">MVGHAPAADAGAPRVSGVIRVGGSAGAQVTEAEPVKQASTAAAEPAAAPRKRRSRRAASSAGAQSKVVTVDAAESAHGSVVASASVADAKAPVESETPTLFGIGVSAADIKRAGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0V8</accession>
    <name>A0A2Z5R0V8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88121">
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        <property type="gene ID" value="RA11412_1822"/>
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        <property type="entry name" value="Ald_DH/histidinol_DH"/>
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        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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    <accession>A0A2Z5R0X8</accession>
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        <submittedName>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="262"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="781"/>
        </location>
    </feature>
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        </location>
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        </source>
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</entry>
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    <accession>A0A2Z5R102</accession>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="RA11412_2118"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="BAV88417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="64" mass="6526" checksum="CC9CB11A1ABBBC79" modified="2018-10-10" version="1">MFLGGSHIFAGLVVFINLRFTTKVLFSSTVGEAEGVAVADSEGDAEGVAEALAVAVRDARGDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R137</accession>
    <name>A0A2Z5R137_9MICC</name>
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        <name type="scientific">Rothia aeria</name>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="208" mass="22108" checksum="2C1495C9E53E57C4" modified="2018-10-10" version="1">MTRPEWIMLGTFIVLLILWIGGSSLGVDATAAAFLGIAILLVTKVLTWKDMAANSSAWSTLIFFAVLVGMADHLKTLKVVEWIGASVASSVGGMAWPLAFGVLALVYFYIHYFFASNTAQIVALYAVFLGAAIAAGTPPMFAALFLGFAGNLIGGITHYASGPAGVYFGSGYIKTGEWFKLGFIASVVNIIIWGLIGTVWMFSLGYGR</sequence>
</entry>
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    <accession>A0A2Z5R175</accession>
    <name>A0A2Z5R175_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
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    <gene>
        <name evidence="5 8" type="primary">rpmA</name>
        <name evidence="8" type="ORF">I6I94_00110</name>
        <name evidence="9" type="ORF">NCTC10207_01283</name>
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    <organism evidence="7 10">
        <name type="scientific">Rothia aeria</name>
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    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004004819.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88300">
        <property type="protein sequence ID" value="BAV88300"/>
        <property type="gene ID" value="RA11412_2001"/>
    </dbReference>
    <dbReference type="GeneID" id="29742943"/>
    <dbReference type="KEGG" id="raj:RA11412_2001"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VEI23185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="85" mass="8990" checksum="28A7A65D117FD1D1" modified="2018-10-10" version="1">MAHKKGASSTRNGRDSNPQYLGVKRFGGQTVNAGEILVRQRGTHFHPGLNVGRGGDDTLFALAAGTVEFGTRKGRKVVNILAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R182</accession>
    <name>A0A2Z5R182_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_2246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRP transporter (TC 2.A.7.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88545">
        <property type="protein sequence ID" value="BAV88545"/>
        <property type="gene ID" value="RA11412_2246"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2246"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="PTHR16119"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06800">
        <property type="entry name" value="Sugar_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="313" mass="33683" checksum="878B938F06F77BD3" modified="2018-10-10" version="1">MVVNVPSKEQLYILCSLIVPKEIFSMNILIGLIPALFWGILPLCVSKIGGKPTQQIMGTTMGVLLMGIATSLLFFPMRIDAWAFFLCFLSGASWAFGQINQYRAFTQIGVSQTMPLSTGMQLVGTSLMGVVAFGDWGTAQAKVIGAVALTLIIIGIWMTTKQEHPEPHSGGNMRSGVITLLISTIGYVGYSFFPNYVSVDGWYKFMPQSVGMVVAAITMSMLTRDGTRPWDKKSLQNIICGVIFSGAALAYLVSIEPHRNGVASGFTLSQMNVIISTLGSILLLGEKKTRLELLYVLGGLALVVIGGVLIGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R185</accession>
    <name>A0A2Z5R185_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88310">
        <property type="protein sequence ID" value="BAV88310"/>
        <property type="gene ID" value="RA11412_2011"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2011"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="1">
        <location>
            <begin position="57"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="255" mass="27498" checksum="A3CA593396A596BE" modified="2018-10-10" version="1">MSEMSYPAIPNPEGVERVYGELLARAPENKMAPRLDAVRRAVEILGDVHRAAPVIHITGTNGKTSTARMIESLLLAHDLRTGRFTSPHLESVTERISINGEPVPDATFVRVWDEILPYLTLVDEEFAARGEPKLTFFESITVLAFAIFADEPVDVVILEVGIGGSWDSTNVADGIVSVVAPVGLDHTDMLGDSLAEIATEKAGIIKPDGYLISAAQDPEVATILLDTARKQNAKYAFEGVEFGVVERARAVGGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1B5</accession>
    <name>A0A2Z5R1B5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_06575</name>
        <name evidence="3" type="ORF">NCTC10207_02336</name>
        <name evidence="1" type="ORF">RA11412_0380</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006889070.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86679">
        <property type="protein sequence ID" value="BAV86679"/>
        <property type="gene ID" value="RA11412_0380"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0380"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI24949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="144" mass="16316" checksum="45E268117DA386FD" modified="2018-10-10" version="1">MSVYRDQLGERSNNLINELLAKGLGLAFYKGKCLEILDVTGWDAKDVYEFVEHLTLADAETADKFQESEQLMAKYSDQLDEMEANQDPNSGKVLEVQTIALATYLMLEEPDKEQRVPVGLEALINSDYPEPKLCDDIEAFLQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1D7</accession>
    <name>A0A2Z5R1D7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrite reductase [NAD(P)H] large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88326">
        <property type="protein sequence ID" value="BAV88326"/>
        <property type="gene ID" value="RA11412_2027"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2027"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="382" mass="40661" checksum="07C970FDDE970FCC" modified="2018-10-10" version="1">MSQHTTATSGRNILVVGAGPAAWRFVRAYHEGAQDAGRASDTITVLNDEPYIPYDRVAIEQLFKDTNKDLTLGDPALWDESTINLVSNTRGESLNRESRIVKGSDGVDYPYDVLVFATGSSAVRIPIPNADSAHVFRTADDVKNMVSEVERLQTKLGRAPRGIVVGGGLLGLEAAEGLKDLGAEPTILDVAPWLLSVEVDQGGGYAVNAQIKATGIDIETGAFISAINKDASGEVISVSVADSTSDEAVIHQIDADLVVFAAGIRPNDELARTAGLETGERGGILVNNACHTSDEHIWAIGEVACVLGRTWGLVAPPTQWQMRSPRICSKATKMLRSKSSISPRNLSSRVYRSLASVTAAAPRKAASKFSSQTPHAACTRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1D9</accession>
    <name>A0A2Z5R1D9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RA11412_2012</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88311">
        <property type="protein sequence ID" value="BAV88311"/>
        <property type="gene ID" value="RA11412_2012"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2012"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="423"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV88311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="783" mass="87417" checksum="C47EDDC79C90B005" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1G8</accession>
    <name>A0A2Z5R1G8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_2042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88341">
        <property type="protein sequence ID" value="BAV88341"/>
        <property type="gene ID" value="RA11412_2042"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2042"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="293" mass="31818" checksum="3F1305CD18E3DDC7" modified="2018-10-10" version="1">MDTIDTSPGVRCSFCDKPRTPARKVVIGPNVNICNECVGLCNDILEEETKRETAPKVRSQRTLATPREIFDHLQDYVVGQEDAKRTLAVAVYNHYKRIQESDNPLLSSRTLAASLGEQIDLGKSNILMIGPTGCGKTYLAQSLAKKLDVPCALVDATTLTEAGYVGDDVENILLRLINAADGDVKKAERGIIYIDEIDKIARKGENMSITRDVSGEGVQQALLKIIEGTVAGVPPEGGRKHPTQTTLEIDTSHILFIVAGAFDGLQERVASRTAPQGSGSARNWRPEKILAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Q9</accession>
    <name>A0A2Z5R1Q9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">def_2</name>
        <name evidence="2 4" type="synonym">def</name>
        <name evidence="4" type="ORF">I6I94_10830</name>
        <name evidence="5" type="ORF">NCTC10207_01409</name>
        <name evidence="3" type="ORF">RA11412_2155</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887508.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88454">
        <property type="protein sequence ID" value="BAV88454"/>
        <property type="gene ID" value="RA11412_2155"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2155"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI23308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="192" mass="20777" checksum="DAEECB0F7CF21805" modified="2018-10-10" version="1">MTILSIRTVGDPVLRSECQPITVFDKELAALIDNMLETMYDVEGVGLAGPQVGIDKQIFTYGGIDDREGYIINPVLETGEETQEGGEGCLSVPGIKSETPRKNWARVRGVDRHGNPLELEGEGLFARMLQHETDHLHGTLFIDKLTGDDRKRVMRTIRAGKYAAVAGKTTAERATRVSGAFGSFGAAGSLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1R3</accession>
    <name>A0A2Z5R1R3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaredoxin-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NrdH-redoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06045</name>
        <name evidence="4" type="ORF">NCTC10207_00022</name>
        <name evidence="2" type="ORF">RA11412_0500</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI21956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86799">
        <property type="protein sequence ID" value="BAV86799"/>
        <property type="gene ID" value="RA11412_0500"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0500"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI21956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="105" mass="11673" checksum="B77EA5BBFA4AEE71" modified="2018-10-10" version="1">MLERQQSTQEQARQVMADGGVVIYWRPGCPFCERLDSKLGELGDHATWVNIWEDPQAEEHVKSLNNGNAVVPTLDTGDVHFVVADVKSRNQAAQLIRNAMEGAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1T6</accession>
    <name>A0A2Z5R1T6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AzlD domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09805</name>
        <name evidence="4" type="ORF">NCTC10207_01640</name>
        <name evidence="2" type="ORF">RA11412_2408</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004005150.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88707">
        <property type="protein sequence ID" value="BAV88707"/>
        <property type="gene ID" value="RA11412_2408"/>
    </dbReference>
    <dbReference type="GeneID" id="29742861"/>
    <dbReference type="KEGG" id="raj:RA11412_2408"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
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    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI23614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="112" mass="11986" checksum="46CB5AB0C01B2CB1" modified="2018-10-10" version="1">MINGHIDSGYIISAVLVAAAVTFVLRVLPFGLKKALAGSEVLDALSHWIPLGAVALLAIYAVSRIDFSSTHTAVPYLAGFVVTALVHLWKKNMVYSMIAGTATCVILINWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="208" mass="22512" checksum="A9AAF25E7149BD0A" modified="2018-10-10" version="1">MRLKAGRICHAPRIPNVIDAAALPLVSLAALQVLRKNLKLQRGQRLLVVGATGGVGHAALQIGQILGVEVSTVSASDNMALCRDLGAVEVYDHEDLPDAANVTPFDAIIDCGGVVTGYYRNYLKPHGRMMTLSPDGLPAVLTSLFTNRRVGFLLATKATAEAMKWITAAVERGNLRPVIEKRYTLEELAEAQDYVDTKHTRGKLLVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1W8</accession>
    <name>A0A2Z5R1W8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_09625</name>
        <name evidence="1" type="ORF">RA11412_2448</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88747">
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        <property type="gene ID" value="RA11412_2448"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2448"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="BAV88747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="44" mass="5412" checksum="66F46D5960D6E6C6" modified="2018-10-10" version="1">MRIWDEVPEHLHSYFDLDAWWRDERYDYTIANAPDGGVFIFRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1X4</accession>
    <name>A0A2Z5R1X4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AzlC family ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I6I94_09800</name>
        <name evidence="10" type="ORF">RA11412_2409</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT88804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88708">
        <property type="protein sequence ID" value="BAV88708"/>
        <property type="gene ID" value="RA11412_2409"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2409"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT88804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="316" mass="34277" checksum="7BB4BAC35D4C7E40" modified="2018-10-10" version="1">MSERSSRPSRHLRDTSQQTSNEQVLDIIASAGLATSSIPVVQEREQALHAGGTHSVELRRTGESGFREAMRAASLVMLGLFFVGIGLGVVIHSLGFPWWLAPLLPGVLFAGSVEFVLLTMMTAGASLVSVAVMTLLINSRHLMYGLSYPIERVHGSLAKFYTVYTLIDEAFALNSGPERHALRGSRILWIHAGMHMSVILSSTLGFFLGSSFLAHLEGFDFVMTALFTVLALDAYRANPDKLTVLFSVIAAVLALIIAPGSMLLVAMAVYMALLMGRYAAAKKRGSLPQHMLVADDPTRSRAARDRVEESPHEPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R271</accession>
    <name>A0A2Z5R271_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_09150</name>
        <name evidence="1" type="ORF">RA11412_2558</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88857">
        <property type="protein sequence ID" value="BAV88857"/>
        <property type="gene ID" value="RA11412_2558"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2558"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="540" mass="58422" checksum="FF533F7F7C856F01" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R280</accession>
    <name>A0A2Z5R280_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 14">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 17" type="primary">guaB</name>
        <name evidence="17" type="ORF">I6I94_09370</name>
        <name evidence="18" type="ORF">NCTC10207_01727</name>
        <name evidence="16" type="ORF">RA11412_2504</name>
    </gene>
    <organism evidence="16 19">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 19">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="17 21" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 21">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 14">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 14"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888789.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88803">
        <property type="protein sequence ID" value="BAV88803"/>
        <property type="gene ID" value="RA11412_2504"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2504"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="101"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="164"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="350"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="373"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="397"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="258"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="310"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAV88803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QQT88720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VEI23792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="505" mass="53525" checksum="E6C5ACAD1A6C9D69" modified="2018-10-10" version="1">MTTPTALSEDPFGFTGLTYDDVLLLPGNTDVIPSDADTTTRLSKRITLGTPIISAAMDTVTDSQMAIAIARLGGLGVIHRNLSIEDQAAHVDRVKRSESGMITNPVTIGADASIDEYDKLCGYYKVSGLPVVSEDGVLEGIITNRDIRYLSRTDYADIYVRDIMTPMPLVTGTPGLTKDEAFTLLSKNKIERLPLVDAAGKLAGLITLKDFVKTEQYPRATKDEDGRLRAGAAIGFFGDGYERAMTLIEAGVDALFVDTANGHSQGVLDMIARLKKDPAAAHVDVIGGQAATRAGAQAIIDAGADAVKVGVGPGSICTTRIIAGVGVPQITAINESAKAAIPAGVPLIADGGMQHSGEIGKALVAGADSVMLGSLLAGTAEAPGDLIFMNGKQFKSYRGMGSLGAMQTRGAHKSYSKDRYFQSDVSSEEKLIPEGIEGQVPYRGPLSAVLHQLEGGLRQTMFYVGSRTIEELKTKGKFVRITPAGLKESHPHDIMMTVEAPNYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R298</accession>
    <name>A0A2Z5R298_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09925</name>
        <name evidence="2" type="ORF">RA11412_2381</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88680">
        <property type="protein sequence ID" value="BAV88680"/>
        <property type="gene ID" value="RA11412_2381"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2381"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="253" mass="25678" checksum="C785CAE2F57B5FF1" modified="2018-10-10" version="1">MNILITLLALATLLIVIYSAVVISSDRAFPGRAFFEHIAGDGLNVFGARTQPAPELAGQQVVVLEPLPDTPAAADNAAAEAVPQESETGEADAAHEAPAAAAAGTSAAEEETPEKAAAAHTDTGRTAQVPDNDVRDHKETEAPQGHPADEPLTSEESAKAATDTGTAPDGAHPATSQQVLPWSEAGRAAHAANTAANAVVASSAKTTVETPAAAKPHEDDSAQHKNSTSGAIVAINKEIADKESAHTTDKADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2A1</accession>
    <name>A0A2Z5R2A1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA modification methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88664">
        <property type="protein sequence ID" value="BAV88664"/>
        <property type="gene ID" value="RA11412_2365"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2365"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00506">
        <property type="entry name" value="D21N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="4">
        <location>
            <begin position="48"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="151" mass="16500" checksum="A00229400E65A40B" modified="2018-10-10" version="1">MSETVPTAATAQSAGAAAPAFDPNGSSLVVQADNLAYLSELPDASFTVIYIDPPFNTGKTQTRRTLKTAPAQEGGARGDRTGFQGKSYTSALQTLASYHDAFEDYWAFLEPRIRQAHRLLTQDGTLYLHLDWREVHYAKVMCDMILGATVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2B2</accession>
    <name>A0A2Z5R2B2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HtrA protease/chaperone protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Trypsin-like peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_10185</name>
        <name evidence="4" type="ORF">RA11412_2312</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88611">
        <property type="protein sequence ID" value="BAV88611"/>
        <property type="gene ID" value="RA11412_2312"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2312"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="338"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT90157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="444" mass="45535" checksum="1A4DE9DA1B7BBD24" modified="2018-10-10" version="1">MTQPGWNQSYGSQQSGYNGAQYPPQYSNQQYGQSRGYSQNQQQYAYAQNQPGSGNNANEYPKNERPGSEPSEPKKHSTGVVLTAALLASLVGAGVGAGVGGGIAASNSGGSGAVSSSASKSSGTTSSSNLNSTDPTVITETAKKVLPSTVTVGVKVGSGSGTGSGEILDTNGHILTNNHVVTDDSTKADQVEVRLHDGTVRTAKIVGTDPASDLAVVKIDPKGLELTPITFGDSSKLVPGDQVVALGSPYDYRDSVTVGVVASASRVTPADNKKTAYIPMIQSDAEINHGNSGGPLVNTRGELVGINTQGYRSTDGGAAAGMSFSVTSNYAKRISDEIIAKGKASHGYLGASVKTTGATTDNGKSKLFEGGVELTDISSGSPADKAGLKKGDVVVEVDGHRIEADEELNGTVRSMAPNTKATFKVQRGSEVKEIQVTLGDSDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2B6</accession>
    <name>A0A2Z5R2B6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large Ala/Glu-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09650</name>
        <name evidence="2" type="ORF">RA11412_2443</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88742">
        <property type="protein sequence ID" value="BAV88742"/>
        <property type="gene ID" value="RA11412_2443"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2443"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="246" mass="27046" checksum="832F8F33E374F23E" modified="2018-10-10" version="1">MERESSERSLENLAKAEYVASMQALDTAEETLARVAALEPEARAEAERLLAAAREKSRGLVIDAELEGEEIITRAELDAEDLMVAAHSRAENVAASAREQGKQEGREEGTNEVANELDRASALATEAEQHLAAVKTSKPLSGEQARALYAEGVRVVAESVSKRVEDAAIRRVIDSVQSAHVNFAEPDKFADFAKAVTAGREQRRERTLDRQQRSQRVIEQRLNEASTTTKSTTHDRDSSNDSFERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2I6</accession>
    <name>A0A2Z5R2I6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MutT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88938">
        <property type="protein sequence ID" value="BAV88938"/>
        <property type="gene ID" value="RA11412_2639"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2639"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="130" mass="14632" checksum="C773CC4CD27B6CA7" modified="2018-10-10" version="1">MPKTTYYSAHTQPNGLALTYTPKNAAEIIAAGALIWRVRNSKIELLIIHRPRYDDWSWPKGKQDAGETIPETAIREISEEVQLRVHLGYPWAPPGTRSTAKPKTSSTGPHSCRRDRNHALTRTKWTISSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2R0</accession>
    <name>A0A2Z5R2R0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Molybdenum transport system permease protein ModB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I6I94_08970</name>
        <name evidence="11" type="ORF">RA11412_2603</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88902">
        <property type="protein sequence ID" value="BAV88902"/>
        <property type="gene ID" value="RA11412_2603"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2603"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="53"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV88902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT88643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="278" mass="29422" checksum="179DBBD4196F257F" modified="2018-10-10" version="1">MKKRTTFSVVPWYFTIPSLIGLALILGPLLGLLYNIPWMGLHEIIDEEVVGATQLSLVTASISTLICGVIGAPLALTLCKVLDRSRLRGAGSLLYAIIYTPIIFSPVVSGLGLLFFWGRKGIIGAALYDAGIKITFTTTAVIIAQVFVALPFFVASAVTTLQAIPREYEEIAEVEGAKASEITYRVLLPLAAPGIATGFLLSFARALGEFGATVTFAGNVKGKTETIPLSIDLAISGGNMSGALGSALMLISLYLCIFGLLGLFSVVKKLRAKASYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2S1</accession>
    <name>A0A2Z5R2S1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">O-succinylbenzoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88993">
        <property type="protein sequence ID" value="BAV88993"/>
        <property type="gene ID" value="RA11412_2694"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2694"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="53" mass="6159" checksum="7E60FBA286D51DB8" modified="2018-10-10" version="1">MRPAAPEEARLKALAADHSTRAWWLERIERCWRLLHRGYATADARHGQETMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2U4</accession>
    <name>A0A2Z5R2U4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88771">
        <property type="protein sequence ID" value="BAV88771"/>
        <property type="gene ID" value="RA11412_2472"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2472"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="149" mass="16127" checksum="21BB0929F12B06EE" modified="2018-10-10" version="1">MQREAAERARRRARQLNLQNPYPQQDPVHQPSSDTAEHTTVPLGQGAAPDVPPVQPPVPHTPVPSTIDESDLDSLDDDVSPVFEPQQQLGTLGSGFEDTSTQGIRLGPGAMPMFKATSNTWEPVELPKPLHTLHQKKGKDGKGKGKTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R325</accession>
    <name>A0A2Z5R325_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88876">
        <property type="protein sequence ID" value="BAV88876"/>
        <property type="gene ID" value="RA11412_2577"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2577"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
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        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="55" mass="6093" checksum="58AE0EDC824BB275" modified="2018-10-10" version="1">MKIVKALVPLTEMFGYIGDLRGKTQGRAVFSMAFDSYGEVPKNVADEIIQKSRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R367</accession>
    <name>A0A2Z5R367_9MICC</name>
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            <fullName evidence="1">Thymidylate synthase</fullName>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:dTMP biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
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        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
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        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
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        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="thym_sym"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <begin position="2"/>
            <end position="128"/>
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        <location>
            <position position="32"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="172" mass="19478" checksum="42A94532EE5BD617" modified="2018-10-10" version="1">MIESLKTTPSSRRHIVSAWNPAEVDEMALPPCHAMFQFYVHERPDGVKELSCQLYQRSADMFLGVPFNIASYALLTYLIAHEVGMEPGEFIWTGGDCHIYSNHLEQVKKQLGYGNDPRVIPIPRVSPTRTPNSLSKRRNLLFLITSMKTLSSSIISIIRGFLPPSRFRTIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R369</accession>
    <name>A0A2Z5R369_9MICC</name>
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            <fullName evidence="3">TIGR02611 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Transmembrane protein (PGPGW)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08805</name>
        <name evidence="4" type="ORF">NCTC10207_01844</name>
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    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
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    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT88612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="VEI23993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88946">
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        <property type="gene ID" value="RA11412_2647"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2647"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013434">
        <property type="entry name" value="CHP02611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019099">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI23993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="116" mass="13789" checksum="9F4483F3467CD08E" modified="2018-10-10" version="1">MKTIEDEVKESETSRFHRWLEKKKARMHAHPVMRHLYKPLVIGVGGFCLIAGLIMLVTPGPGWLFIFIGLGIWGTEFAWAHHLNQRLKRLVLRIWHWFKERHAERKARKTEARRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R370</accession>
    <name>A0A2Z5R370_9MICC</name>
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        <submittedName>
            <fullName evidence="3">DUF4235 domain-containing protein</fullName>
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    </protein>
    <gene>
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        <name evidence="2" type="ORF">RA11412_2741</name>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT88544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_JPVS01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89040">
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        <property type="gene ID" value="RA11412_2741"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000250241">
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025329">
        <property type="entry name" value="DUF4235"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14019">
        <property type="entry name" value="DUF4235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="79" mass="8314" checksum="928016A474969DB2" modified="2018-10-10" version="1">MNPVAKIAITGVNLAASALVGKGLSYVWKGVTGNEPPTIAPESEDTVRNVIIWAVLTSVVGTLVSIGIARAQRRFLPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3A1</accession>
    <name>A0A2Z5R3A1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_08530</name>
        <name evidence="3" type="ORF">RA11412_2712</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89011">
        <property type="protein sequence ID" value="BAV89011"/>
        <property type="gene ID" value="RA11412_2712"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2712"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV89011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="165" mass="17427" checksum="4452B8D815CAF0C4" modified="2018-10-10" version="1">MQYLGRARKNTTAADNTGTQDTVKKEEGSVVPLIAGLCALLLLIGSVTLAITGAHVQTQRLTDFADAQASAVARRLQQEQRMVGVGNGVSGARGYEYAAEYLAASGASREFENLRIDSVEVADGDTVRVRLSGRIHPPLVSIVVPDGIEVSAYSSARLNTLQPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3B1</accession>
    <name>A0A2Z5R3B1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Protein export cytoplasm protein SecA ATPase RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08445</name>
        <name evidence="2" type="ORF">RA11412_2732</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89031">
        <property type="protein sequence ID" value="BAV89031"/>
        <property type="gene ID" value="RA11412_2732"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2732"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="232" mass="27169" checksum="7E2176045BCFE5B1" modified="2018-10-10" version="1">MRYNDYQQPIGDALPDYRAGEAPSVDCLQGRYCRLEKLDAERHGDDLYEVYGPEAPKPSFTYLSLNPVADRAELETLLKRMEESTDPYYLTVIDQDGRAIGTLALMRINPAHRVIEVGSVTYGERLKRTRAATEVQYLLAQYVFETLHYRRYEWKCDALNEPSRRAAERLGFTYEGTFRQAVVYKGRNRDTAWYSMLDTEWEQRKHRLLQWLDPKNFDAHGQQRTSLREIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3G7</accession>
    <name>A0A2Z5R3G7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Imidazole glycerol phosphate synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Imidazole glycerol phosphate synthase amidotransferase subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="3">2.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hisH</name>
        <name evidence="2" type="ORF">I6I94_02930</name>
        <name evidence="3" type="ORF">NCTC10207_00692</name>
        <name evidence="1" type="ORF">RA11412_1290</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.-" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87589">
        <property type="protein sequence ID" value="BAV87589"/>
        <property type="gene ID" value="RA11412_1290"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1290"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT90072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI22611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="231" mass="24613" checksum="1F750FE12AED586B" modified="2018-10-10" version="1">MAQEQPVVAILGEPGTFGELAQALGRAGAQVLVTKTSNELLDADGMIIPGHTSSIETYRTVQSFDAERVVGRRVAGGRPVLFAGAAFGMLFETMDDTTSAGAVEVKGMGEWPGHACKLAAAGAPLGVQQLVPAQESSLLHNLPGALRYKAEDGVLRWEFEQNIDYMRAPAVSWTQTTPPYIAAVENGPLTAVQFCPIASGEPGEEFMRRWVASLPVTGRMSVVVENNVEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3P1</accession>
    <name>A0A2Z5R3P1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87719">
        <property type="protein sequence ID" value="BAV87719"/>
        <property type="gene ID" value="RA11412_1420"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1420"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="60" mass="7197" checksum="632035FD79AC0CB1" modified="2018-10-10" version="1">MTPGPHETEYWYNTSTGEVEEGQQSKITHLWGPYKTREEAEHAMETAQKRNEEWDNQWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3P7</accession>
    <name>A0A2Z5R3P7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87759">
        <property type="protein sequence ID" value="BAV87759"/>
        <property type="gene ID" value="RA11412_1460"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1460"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="4957" checksum="94A710DDBB4CAFFC" modified="2018-10-10" version="1">MEHDETQQEAVAEVFNELGFVRVRCVHDLTGRPRHTCGYRPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R511</accession>
    <name>A0A2Z5R511_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <shortName evidence="6">DHNA-octaprenyltransferase</shortName>
            <ecNumber evidence="6">2.5.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">menA</name>
        <name evidence="8" type="ORF">I6I94_08455</name>
        <name evidence="7" type="ORF">RA11412_2730</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26478"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:11173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="EC" id="2.5.1.74"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MenA family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.74" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037287372.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89029">
        <property type="protein sequence ID" value="BAV89029"/>
        <property type="gene ID" value="RA11412_2730"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2730"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01937">
        <property type="entry name" value="MenA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004657">
        <property type="entry name" value="MenA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV89029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="296" mass="31087" checksum="B7DC0483AB00AB60" modified="2018-10-10" version="1">MASPAEWIEGARLRTLPLALAPIVAGSVAAAELHSFRPLRAVLALLVAFFLQVGVNYANDYSDGVKGTDEGRVGPMRLVGSGAASPKAVKFAAFLCFGLAVCSGVLLVALANQWWFLAVGASALFAAWGYTGGKRPYGYMGLGDVFVFIYFGLVATLGTLFTQTNQLTLTGWVGAGAVGLISCALLMANNVRDIPTDSESGKLTLAVRLGDRAARITYAVEMILAILLCTVLVPQNPWFALIFVLVGPTVYSCVTVLSGRTGKDLIPVLKQAGIVALAYSLLMGLAVFLGNFNSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R518</accession>
    <name>A0A2Z5R518_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thiazole synthase</fullName>
            <ecNumber evidence="4 6">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiG</name>
        <name evidence="9" type="ORF">I6I94_08360</name>
        <name evidence="8" type="ORF">RA11412_2750</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiG family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4 6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89049">
        <property type="protein sequence ID" value="BAV89049"/>
        <property type="gene ID" value="RA11412_2750"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2750"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiG" evidence="7">
        <location>
            <begin position="3"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="200"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="6">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV89049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="251" mass="26178" checksum="EF288455CC285184" modified="2018-10-10" version="1">MIIAEKEFSSRLIMGSGGTTSMDLLEKALVASGTEMTTVAMRRHASGTPIFPLLTRLNIAPLPNTAGCRTARDTVITARLAREALGTNWVKVEVISDEDTLLPDVCETVTACETLVAEGFTVMAYTSDDPVIAKRLEDVGVAAVMPLGSPIGTGLGILNPHNIELICSRATVPVLLDAGVGTASDAAFAMELGCSGVLLASAVNRAQDPVAMARAMKAAVEAGYLARSAGRIPQREHAKASSPAEGLVSWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QV85</accession>
    <name>A0A2Z5QV85_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_08140</name>
        <name evidence="3" type="ORF">NCTC10207_01980</name>
        <name evidence="1" type="ORF">RA11412_0002</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887596.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86301">
        <property type="protein sequence ID" value="BAV86301"/>
        <property type="gene ID" value="RA11412_0002"/>
    </dbReference>
    <dbReference type="GeneID" id="32323265"/>
    <dbReference type="KEGG" id="raj:RA11412_0002"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI24235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="98" mass="10384" checksum="2B7015BF3BA41524" modified="2018-10-10" version="1">MRLPLLSAPPAGAVLADTEDDAVELAEDDALLLALAEDEEADAADEDDAEAEDDALELEAADDEELFDAELFELPHALKPSIATILSDTTAEAGRIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVA6</accession>
    <name>A0A2Z5QVA6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86325">
        <property type="protein sequence ID" value="BAV86325"/>
        <property type="gene ID" value="RA11412_0026"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0026"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007841">
        <property type="entry name" value="UPF0210"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37560">
        <property type="entry name" value="PTHR37560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05167">
        <property type="entry name" value="DUF711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="302" mass="31956" checksum="36484669CD4E3CD6" modified="2018-10-10" version="1">MMNDNILETLRMIEEEKLDIRTVTMGISLLDCADSNGAVARQKIYDKITSRAKNLVSVCEGIEAELGIPIVNKRIAVTPIAVIAGASSENDYIEYARTLDAAAKAVGVNFIGGFSALIDKGATPADNTLMNSIPTALAETDVVCSSVNIGSSRAGINMSGVKRMGEVVRETADLTAETNGFGCAKLVVFANAVSDNPFMAGAFHGVQEADTTISVGVSGPGVVHRALHKVRGARFDACAEAIKQAAFKITRVGQLVGSLAAERLGVYFNIVDLSLAPPPKSGTPWRTSSKNWGWKPWEPTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVA8</accession>
    <name>A0A2Z5QVA8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_0029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86328">
        <property type="protein sequence ID" value="BAV86328"/>
        <property type="gene ID" value="RA11412_0029"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0029"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="PTHR10309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="290" mass="31705" checksum="FB2D8FA865E4560B" modified="2018-10-10" version="1">MGEIFRLKNKIQNYAWGSRSILGRMRGVPVPTDKPEAEVWVGAHPAAPSVATVDGSEQQLDELVAQQPGRFLRPDRNSDWFPFLFKILAIDAPLSIQVHPTDEQAAAGFEAEQARGVPLDAPHRNYKDRYSKPETVIALTNMRVLTGVRPAEQLKNLARAFNASWLADRAHLAPKELLTAIIRMPEPEAAQAVDQLAATAHKLAQTRRKAAPSVLDAIELVNLVAHKYPGDRGLLVAFVMNLVHLAPGDSAFTPDGQVHAYVSGTAIELMNPSDNVMRAGLTPNILTLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVB6</accession>
    <name>A0A2Z5QVB6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitrite-sensitive transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86333">
        <property type="protein sequence ID" value="BAV86333"/>
        <property type="gene ID" value="RA11412_0034"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0034"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="70" mass="7508" checksum="17423BC5C0DE393A" modified="2018-10-10" version="1">MIECEDQDGNCPLDSFCRLRNVLADAREAFYAAVDDVVISDLPGPARPAGPVFVELGLGPLAASFDREVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVC4</accession>
    <name>A0A2Z5QVC4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavohemoprotein</fullName>
            <ecNumber evidence="6">1.14.12.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Flavohemoglobin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Hemoglobin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Nitric oxide dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">hmp</name>
        <name evidence="20" type="ORF">I6I94_08030</name>
        <name evidence="21" type="ORF">NCTC10207_02011</name>
        <name evidence="19" type="ORF">RA11412_0033</name>
    </gene>
    <organism evidence="19 22">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 22">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 23">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="20 24" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 24">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family. Two-domain flavohemoproteins subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86332">
        <property type="protein sequence ID" value="BAV86332"/>
        <property type="gene ID" value="RA11412_0033"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0033"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051409">
        <property type="term" value="P:response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
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    </dbReference>
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        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023950">
        <property type="entry name" value="Hmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="PTHR43396:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="21" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLOBIN" evidence="17">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="151"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00014637"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030024"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00030929"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="BAV86332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QQT88478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VEI24297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="389" mass="43032" checksum="D6E2CD01397AC209" modified="2018-10-10" version="1">MLSEKSRPIIEATLPIIADRIGHITPDFYERMFAARPDLMDGLFSRSSQLEGTQPKALAGSIAVFASYIVEHPDSYPDEVLSRVAHKHASLGLQEKEYPTVYKYLFEAIAADLGDAATEEVVDAWSEVYWLMANALIKIERGLYASQANNVTHAPFKVVDRQETGDNVVVLTFEPADETPMTEAKAGQYISIITKARDGLRQPRQYTLLPSDKNQRRIGVKLDPNGEMTSIIHGLTIGDVVEISNPYGDLTLEGFGSADAPLYLFSAGIGVTPMISFLNELIESGSQRQVTVVHADRRLDTWPLREEMTALVEKLPHGKLVTFMEDEETGDYRGRVDIAKLGVPAEANVYLCGPLPFMKGVRSALVDAGVPAQNINYEIFGPDQWMLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVC5</accession>
    <name>A0A2Z5QVC5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malonic semialdehyde reductase</fullName>
            <ecNumber evidence="3">1.1.1.298</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07980</name>
        <name evidence="2" type="ORF">RA11412_0044</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.298" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037236980.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86343">
        <property type="protein sequence ID" value="BAV86343"/>
        <property type="gene ID" value="RA11412_0044"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0044"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="194" mass="22142" checksum="9ECDB99B238555DE" modified="2018-10-10" version="1">MTRLSEDQITALFREPRTMRKFTDRPVTDDQLREIQELTYLGPTAFNSQPLRITWIKSPEARERLVKHLIEANQEKARQAPVNAILSYDKAWIDRADVFNPRAAETIRSYCTTEEIVTFAAQQSANLQAGYFMTAARALGLDAGPLWADFEGLYEEFFAGTDEHPILVVNLGYGVPTQHPRDTRFGFDEVTRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVD8</accession>
    <name>A0A2Z5QVD8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86355">
        <property type="protein sequence ID" value="BAV86355"/>
        <property type="gene ID" value="RA11412_0056"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0056"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="69" mass="6536" checksum="5B32F32388C285B9" modified="2018-10-10" version="1">MSTAAQEPTVGTAPATVSDEPTWGTITTSSAAAGAPTATAAGESASAAAGSGQGGANNNPKNPRLPPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVI5</accession>
    <name>A0A2Z5QVI5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 8" type="primary">sucD</name>
        <name evidence="8" type="ORF">I6I94_07745</name>
        <name evidence="7" type="ORF">RA11412_0106</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004005553.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86405">
        <property type="protein sequence ID" value="BAV86405"/>
        <property type="gene ID" value="RA11412_0106"/>
    </dbReference>
    <dbReference type="GeneID" id="29743678"/>
    <dbReference type="KEGG" id="raj:RA11412_0106"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV86405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="305" mass="31167" checksum="236CA9774F2B81CF" modified="2018-10-10" version="1">MSIFVNKDSKVIVQGITGGEGTKHTARMLAAGTNIVGGVNARKAGTTVTHKAKDGSDVELKVFGTVAEAIAETGADVSIVFVPPAFTKAAVLEAIEAKIGLVVVITEGVPVQDTAEFWAAAKASVDENGKQITRIIGPNCPGIITPEECLVGITPANITGKGKIGLVSKSGTLTYQMMFELADIGFTTAIGIGGDPIIGTTHIDALEAFEADPETEGIVMIGEIGGDAEERAAEYIKANVTKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAQAKKEALEAAGVKVGKTPSEAANLMREIFANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVJ6</accession>
    <name>A0A2Z5QVJ6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">NADH-flavin reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07765</name>
        <name evidence="4" type="ORF">NCTC10207_02066</name>
        <name evidence="2" type="ORF">RA11412_0102</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887612.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86401">
        <property type="protein sequence ID" value="BAV86401"/>
        <property type="gene ID" value="RA11412_0102"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0102"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI24404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="225" mass="23856" checksum="CB909A6DD39E9BB9" modified="2018-10-10" version="1">MKILVLGASGRTGSLFTRKALEEGHTVTAYVRNPDKAVALLGAHQNLIIVPGALNDSEQLATISSGQDVMVSILGQKATVREFLSTKFMQKRLPLIMEAVVGAGVPHCVLMSAYGVGDTVRSASFLMRVACKTIMRSIFRDRAKADAMVAKYQPYISRALPGRLTDEPGKGGAKVVDVTSVAHVPGIPTIAREDVADALLDIAGDPLNAGTDFLVTIEDVVIRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVL3</accession>
    <name>A0A2Z5QVL3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Putative dihydrolipoamide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I6I94_07635</name>
        <name evidence="12" type="ORF">RA11412_0138</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86437">
        <property type="protein sequence ID" value="BAV86437"/>
        <property type="gene ID" value="RA11412_0138"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0138"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0274">FAD</keyword>
    <keyword evidence="2 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="11">
        <location>
            <begin position="8"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="10">
        <location>
            <begin position="349"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="8">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV86437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT88404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="468" mass="49617" checksum="512C7DC2AA24C6C0" modified="2018-10-10" version="1">MTTARLHFDMVVIGFGKGGKTLAGAYAKTGKNVALIEQSSNMYGGTCINIGCVPTKALVHRADEFRALGEHNAEAANAAYESAVIFRDKLTGAMRAKNREILESNATAKLIDGHARFLSDTEVEVTAGEDKLVVTADCFIINTGAVATIPPIPGARESKRVLTSTELQKLTPRPKRLGIIGGGPIGVEFAGIFSSYGTKVTLLEGAPALFGRYDDDVAQAAREIIADQGITAHAGVRVESVTDNADSVTVNYLDSEGASKHLEVDYVMVATGRKPATEGLGLENTSIETTEHGAIAVDEHLRTTAPNIFALGDVNGGPQFTYISLDDYRVVLSQLLGDGSRSTKDRQAVAATIYMNPPLSSIGLTERDALAAGHTIKVAAKPVAAIAAMPRAKTLENPRGIMKFVIDAETDQILGAQLLVVESMEVINLVALAMRHNITASQLRDEIYTHPSITEGLNEVLAVAQPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVM5</accession>
    <name>A0A2Z5QVM5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07665</name>
        <name evidence="4" type="ORF">NCTC10207_02089</name>
        <name evidence="2" type="ORF">RA11412_0127</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887070.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86426">
        <property type="protein sequence ID" value="BAV86426"/>
        <property type="gene ID" value="RA11412_0127"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0127"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI24453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="96" mass="10287" checksum="7606A35EE65D2F56" modified="2018-10-10" version="1">MAQFIVDSEVIASKSAQAKAHVASITAEVNGMTASLQDLQSSWTGSASTNFQGVLDKWRATQRQVEESIAQINEALSRAGVNYSDTEQSNASMFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVM9</accession>
    <name>A0A2Z5QVM9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uracil-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_0156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86455">
        <property type="protein sequence ID" value="BAV86455"/>
        <property type="gene ID" value="RA11412_0156"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0156"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="94" mass="10426" checksum="EF98DBA2C4DD8C20" modified="2018-10-10" version="1">MSEYPPLSSIMHEEWAQALAPVEPQIRAMGDFLRTEHAAGHRTFPAGDDIFRAFARPMSEVKVLILGQDPYPTPGTPWACHSQCTAMCAPCRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVP2</accession>
    <name>A0A2Z5QVP2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LytR_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86452">
        <property type="protein sequence ID" value="BAV86452"/>
        <property type="gene ID" value="RA11412_0153"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0153"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="86" mass="8827" checksum="16ECCEBBCCA42341" modified="2018-10-10" version="1">MAVYNASAPSGSASRAAAKLKSYTISETGNWPGNPPQSSTVYYKSGAQQQAQQVANAVGISNVQEGTAEDLGSNDTVVVLASDFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVW7</accession>
    <name>A0A2Z5QVW7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_07105</name>
        <name evidence="1" type="ORF">RA11412_0248</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86547">
        <property type="protein sequence ID" value="BAV86547"/>
        <property type="gene ID" value="RA11412_0248"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0248"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="97" mass="11616" checksum="AB176C104DAEFFF7" modified="2018-10-10" version="1">MHALGNLIYRQLPNGENQYFQYDTENQLVRAEIKKKAGNTEIWEYAYDPFGRRLSKERKDKLAWTSTEPKRTHFVWDGTRLAQEYTYQGSHTHLYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVW9</accession>
    <name>A0A2Z5QVW9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86531">
        <property type="protein sequence ID" value="BAV86531"/>
        <property type="gene ID" value="RA11412_0232"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0232"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="5117" checksum="4414D2FF052DB536" modified="2018-10-10" version="1">MYDEYPITHETAEKIGHYVDGELKASGYNYFLSCDEDVQTLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVY5</accession>
    <name>A0A2Z5QVY5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Tetracenomycin polyketide synthesis O-methyltransferase TcmP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_07025</name>
        <name evidence="1" type="ORF">RA11412_0257</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86556">
        <property type="protein sequence ID" value="BAV86556"/>
        <property type="gene ID" value="RA11412_0257"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0257"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016874">
        <property type="entry name" value="TcmP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028177">
        <property type="entry name" value="Polyketide_synth_Omtfrase_TcmP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="271" mass="31444" checksum="B09E3244072CEE7C" modified="2018-10-10" version="1">MLHLEDSVSETLLIPLYMKHLASQMPNPVIHDEAATRLVRQLDYDFSKYDHIIHTVVGTAIRADYFDRLTADFIHRRPNPVVVNVGCGLDSRRERIGAAADGVPFYDIDLPDVIALRQKLLPAQRGETLLATSAFDAGWMDELNRLHPNAQFLLVIEGVLMYFDRYTVRALFCDLARRFHRSEAAFDVQNSWMVKNSDRHEALKHVRARFVFGCDDDLEFERWADNLHLMSVKRLTVDFPMWKRSGFLLSLIGRQIPAFRDSTRMLHYRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVY9</accession>
    <name>A0A2Z5QVY9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_0269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86568">
        <property type="protein sequence ID" value="BAV86568"/>
        <property type="gene ID" value="RA11412_0269"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0269"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07474">
        <property type="entry name" value="Peptidases_S8_subtilisin_Vpr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034213">
        <property type="entry name" value="S8_Vpr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="SLH" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="6">
        <location>
            <begin position="1062"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV86568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="1183" mass="124922" checksum="6A4E889066C62505" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW58</accession>
    <name>A0A2Z5QW58_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_06685</name>
        <name evidence="3" type="ORF">RA11412_0348</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037233858.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86647">
        <property type="protein sequence ID" value="BAV86647"/>
        <property type="gene ID" value="RA11412_0348"/>
    </dbReference>
    <dbReference type="GeneID" id="32322251"/>
    <dbReference type="KEGG" id="raj:RA11412_0348"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="519" mass="56281" checksum="35C12AF00D3B0DAD" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWF2</accession>
    <name>A0A2Z5QWF2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86738">
        <property type="protein sequence ID" value="BAV86738"/>
        <property type="gene ID" value="RA11412_0439"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0439"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="4766" checksum="EB5678786CE7EA7A" modified="2018-10-10" version="1">MGERDGGRTACGVWTVRSVSENALMMGKIVKTIRVIVLSNGPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWH1</accession>
    <name>A0A2Z5QWH1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_06975</name>
        <name evidence="6" type="ORF">RA11412_0275</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86574">
        <property type="protein sequence ID" value="BAV86574"/>
        <property type="gene ID" value="RA11412_0275"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0275"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="529" mass="54944" checksum="1A6A2B36F5D0A42A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX29</accession>
    <name>A0A2Z5QX29_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="6">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tilS</name>
        <name evidence="9" type="ORF">RA11412_0698</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86997">
        <property type="protein sequence ID" value="BAV86997"/>
        <property type="gene ID" value="RA11412_0698"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0698"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015262">
        <property type="entry name" value="tRNA_Ile_lys_synt_subst-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09179">
        <property type="entry name" value="TilS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="7">
        <location>
            <begin position="45"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="TilS" evidence="8">
        <location>
            <begin position="305"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="388" mass="40959" checksum="69DB6C226B8E5A6E" modified="2018-10-10" version="1">MGKARRELARALTNLLGEGTIKGTGRARRDSTVSQQGAETEKPLVLVACSGGPDSLALACIAAHFARRSDVRVGAVVVDHGLQADSAEVAASTAETLTNLGLHPVLTERVQVPQGTMGPEMAARTARYGALERAVHNTGARAVLLGHTLDDQAETVLLGLGRGSGTRSLAGMPPVRIENGVTYLRPFLALRRADMLNVCEAEGAAPWNDPTNTDQTLMRARIRHTILPFLQEHLGGDVALSLARTAAVAGPDAEYLDALAAAEYARLKLPNGVHLSDIPGADTVPGDHSTEAVSEKPAPTVIALNRAETAALHPALRMRVLALATRAAQGENPGFERLQALDQFVAEHATAGPVQLPGHVSAYRRRRVQDPRTGTRVDALVLLGRSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX37</accession>
    <name>A0A2Z5QX37_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86941">
        <property type="protein sequence ID" value="BAV86941"/>
        <property type="gene ID" value="RA11412_0642"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0642"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="249" mass="28635" checksum="753A9D5CB71D4DFB" modified="2018-10-10" version="1">MYTEGMSQEITEETATTWYNHCLTLDPPVPAEWGVDQETREAIEGSIRSHLAMGVGDPEQYTEMILDSIDYLPDDDRDTEESSCPTEEAINAYARQVIERHRNLAQELGITREDGNLERAFAQLAEEGILGRSNFTCCGTCGNYEIVDERDSSRTWYGYVFYHQQDAEAIPQGRGVFLGYGIFWPAHCTKEQFEAMSEEEKDEIYERLSVAMMRDKVVPVLERNGMQVDWNGDFSRRPYIHNVWAFEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXG8</accession>
    <name>A0A2Z5QXG8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86924">
        <property type="protein sequence ID" value="BAV86924"/>
        <property type="gene ID" value="RA11412_0625"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0625"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="5167" checksum="C6D49F2B894C2284" modified="2018-10-10" version="1">MLLWLPGTNAFMFNSKVYRLAQNPFVQPVIVHPQHVQPQKPHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXI0</accession>
    <name>A0A2Z5QXI0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87157">
        <property type="protein sequence ID" value="BAV87157"/>
        <property type="gene ID" value="RA11412_0858"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0858"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="148" mass="16700" checksum="69DC72F1B3DC10BB" modified="2018-10-10" version="1">MLVAGQLGENENGLLFRAIGVTHSEHTVFPRKIVGMIFKKVGAHRPYPQHGMSNADWGSIPPQQVRLDWLTTTQKTLDLETLLAEDSTYFGDLFPHVVKWQQELYLEDGLHRALRTALHSRSVMYARILDLDTLDPRLLPQGANAQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXK7</accession>
    <name>A0A2Z5QXK7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_0888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87187">
        <property type="protein sequence ID" value="BAV87187"/>
        <property type="gene ID" value="RA11412_0888"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0888"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016258465" description="ABC transmembrane type-1 domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="247" mass="26855" checksum="FA9859D8D531FC39" modified="2018-10-10" version="1">MGALAASVVSVLVAAVAAAAQPVLIARVLDTAIAPVTHGDTGPLLTLLAVFAVSVLVNAGATWANVAYTVRVSLGVLLHLRTRVFKHSQALSVSFHESYTSGRVISRLTNDVETIATFLGSGLSQLVTTLLNMLFSVVAIFVLDWRIGVLLLLTGVPIYLLTRWFQRGISRIFRSLRNESAQLTTRFVETFTGIRAVKGFGAEAAARAEYAAVAERYRVSVMDSIKMFGIYSPLSCFSGMCLWRRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXL5</accession>
    <name>A0A2Z5QXL5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NAD(P)H-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_04440</name>
        <name evidence="2" type="ORF">RA11412_0898</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87197">
        <property type="protein sequence ID" value="BAV87197"/>
        <property type="gene ID" value="RA11412_0898"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0898"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="211" mass="23366" checksum="D1E83382F311E82E" modified="2018-10-10" version="1">MKILVSGATGNVGRLVVEQALARGHEVVALARNPQNLQREHPNLTTGAVDILDAQALKPWLQGVDAVISTVGIGTSKTPTTLYSAGTKNLLDAMQEHGVSRLVVISSEVAEHWAHQGLFKLWVVLPLLQHFLGATYDDMRRMDVVLWESTAQWTAVRAPRIQPMKPKGSYRLDAHKPLRRGWMITPADMATALLDIAEREDLNRQHVYVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXT9</accession>
    <name>A0A2Z5QXT9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ccs1/ResB-related putative cytochrome C-type biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_0978</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87277">
        <property type="protein sequence ID" value="BAV87277"/>
        <property type="gene ID" value="RA11412_0978"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0978"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="7">
        <location>
            <begin position="6"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="384" mass="41637" checksum="57500BBA6848D181" modified="2018-10-10" version="1">MQIRDEGGGQYSVGAERGYLREVGNILFHVAMIGILVGVAVGSLFGYRGQKILVEGETFVNSLIGYDSFTPGTNYNPDWLSPYAVTLNNFQVRYDRQRDSHTYGQDLDYNAQLTVQNPGSSPEQKTLKVNEPVDVGGTSVFLSGNGYAPIVKVTDGEGKVAYEGPVVALPTDGKYTSSVVLKVPDARPAQLGFMGMFLPTGSYERGAGIPHSVDSAPANPMLVLQSYSGDLGLNSGQPQNVYVLDTSKLTALNSMANQNGIVLDAQHRTATLPEGNGTIEFMGYKRYVGMEVRHDPGQNIVLYSFVVAFVGLIVSLFVARRRVWVRASTDEGVLTVEYGLLARGEDPRLAAEAERITDAFAARWGLEFAEEPSSEEPTEKTEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXV5</accession>
    <name>A0A2Z5QXV5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87288">
        <property type="protein sequence ID" value="BAV87288"/>
        <property type="gene ID" value="RA11412_0989"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0989"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="526" mass="59342" checksum="23910DACBA559202" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXY0</accession>
    <name>A0A2Z5QXY0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0887</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87186">
        <property type="protein sequence ID" value="BAV87186"/>
        <property type="gene ID" value="RA11412_0887"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0887"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="86"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="119"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="328" mass="34977" checksum="392795E28F70B25A" modified="2018-10-10" version="1">MAAALVIGGYAVLGGTMQVGTLLALIIYANRVFEPIMTLSEFYNLFQSAFSALEKISGFLAERPQVREAEHPVQRQVLEGAARGAVEFQNAQFAYVEGTPALQRTSLSVPAGQRVALVGATGAGKSTIAKLLSRFYDVSDGRVLLDGVDIRRLSDAQLRQEVVMLTQEVFLFSDTIAGNIRLGNPNATDEQVVAAAQAVGAHGFISALPQGYQTMLGRAGTNLSAGQRQLVSFARVFLADPNVVILDEATASLDIPSERAVQRALNTLLSGRTAFIIAHRLSTVLAADRVLVIDAGEVVEDGSPQALTATGGRFATMRASWDELNNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY08</accession>
    <name>A0A2Z5QY08_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87241">
        <property type="protein sequence ID" value="BAV87241"/>
        <property type="gene ID" value="RA11412_0942"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0942"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="474" mass="53355" checksum="FF21884DDDDE5DEB" modified="2018-10-10" version="1">MEQLGSKEAPVRIGGVYTLVGLVDEWLLDENLDYTEKVREGQVIINSLCAYIRSSFALAFHYDELAQESPTAEGLYKNREQEFYIDKAALESEADIRLSIIKEIHDRLQSPEINTPGAWSDFEYDFSGSTFFYPIDFTRSYYAKPVNFSGSAYQDEVRFGGSTYQGGADFSGSIYWRGADFLSSTYQSQANFTGSTYQDKAVFSSSTYQDGANFSGSTYQGEVFFRGSVYRGWVVFNGSTYREEADFCGSTYRRGADFSNSTYWGKIVFGGSVYQGWAVFRDSAYRGEAAFNDSVYWGGADFSGSTYRGRTGFGNSIYQEGANLSRSIYWGEANFSGSIFCSEIYFGQDGDNSSFSRFTDCTPQFYDETNHKNTLFGSHNNDFTVENGRGYPIYRAFEGLPLGCAFLTAEQKEYLEDKFHEIGKTKNKFREVKDTEGNAIFVNTPLSLNGEIRVWREKVTTVKAEGTTSGEQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY16</accession>
    <name>A0A2Z5QY16_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA topoisomerase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87233">
        <property type="protein sequence ID" value="BAV87233"/>
        <property type="gene ID" value="RA11412_0934"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0934"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="9"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="187" mass="20564" checksum="E36148F071CCE7FC" modified="2018-10-10" version="1">MPTKAKNGKALLIVESPSKVKTISGYLGGEFLVDSSMGHIRDLPQPSELPENLKKGPVGKFAVNIDDDFDPYYVVNPDKKKKVAELKRKLKDVDALYLATDGDREGEAIAWHLKEVLKPKVPVYRMTFPEITREAIERAFGNCAILTCTWSMPKKPAVSLTVSTVTKSHPCSGARSAAGYLRAVYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY34</accession>
    <name>A0A2Z5QY34_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87377">
        <property type="protein sequence ID" value="BAV87377"/>
        <property type="gene ID" value="RA11412_1078"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1078"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010178">
        <property type="entry name" value="Integral_membrane_1906"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07314">
        <property type="entry name" value="DUF1461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="347" mass="38579" checksum="1D132666744065C9" modified="2018-10-10" version="1">MSRDARQKEQEEALAAAQSVEEAEATEAAKEKPRQKEYRTETTTSNKVVRVAADPDEVDIPKEYIDVPKPGKAEAVKVAPKAELIVLDKPPLLRLRSTIITLAVPILVIMIAVRAVASDAFLWLEYHRPGFPADAYGFDTAERMRLGSYGLNYVTNFAPRSYLESITTGAEHKSAFLPDEVGHMHDVKLVILYSTAAAVLMLILAFISSATLRERAPGVIRRSLFTGAWLTVGILGVLAAVGIFSWDWLFTTFHTTFFPQGNWQFHLNDTLIRLYPPQFWVDAAIAVAALSMLIVLLLMGYTWPTRYRKQVALRRSAERFAALQKADAQVQEAKQVSASQQASRSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY45</accession>
    <name>A0A2Z5QY45_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87263">
        <property type="protein sequence ID" value="BAV87263"/>
        <property type="gene ID" value="RA11412_0964"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0964"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="133" mass="14841" checksum="C8607DFB7A2310F7" modified="2018-10-10" version="1">MRSGGGIQHPDIRVHEDRYTKEAPHAHVLSKVFAVNRLETVVGCARTLPLDDAVVIADGALSRQQEGARLDYSEVQDALLSSPRKGAAKAREVARLMSDKSDSPGETLTRLRLYEYGLSPLSNTRLRRRWVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY79</accession>
    <name>A0A2Z5QY79_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-glucose 4,6-dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87425">
        <property type="protein sequence ID" value="BAV87425"/>
        <property type="gene ID" value="RA11412_1126"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1126"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="122" mass="14138" checksum="C3506F33253E2782" modified="2018-10-10" version="1">MRDWIHASDHSSAVLRILESGKIGETYLIGADGEENNITVLRTILRLMDKDENDFEHVIDRPGHDMRYAIDGTRLREELGWEPQFTNFEAGLADTITWYTDNRSWWEPLKAEVEAKYAKVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY99</accession>
    <name>A0A2Z5QY99_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2505 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Protein of uncharacterized function (DUF2505)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_03515</name>
        <name evidence="3" type="ORF">NCTC10207_00567</name>
        <name evidence="1" type="ORF">RA11412_1139</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888039.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87438">
        <property type="protein sequence ID" value="BAV87438"/>
        <property type="gene ID" value="RA11412_1139"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1139"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019639">
        <property type="entry name" value="DUF2505"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10698">
        <property type="entry name" value="DUF2505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI22490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="165" mass="17427" checksum="51B3E445E54004C3" modified="2018-10-10" version="1">MSVQESTVVNVTVEQIATAYASEDFARFVCSEVGVEFESFSLEGDASGEFTATTVRTIPSDRVPDIARKFVSNGVNMTQVDRVSAPAADGSRTVDTEVKVNGMPVNAKASQALVSQGEQTRVDVNGEVSCSIPLVGKKIAASAEPQVGRVLKVLGTSAEKWTAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYC6</accession>
    <name>A0A2Z5QYC6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine phosphatase PPP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87477">
        <property type="protein sequence ID" value="BAV87477"/>
        <property type="gene ID" value="RA11412_1178"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1178"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="292" mass="32361" checksum="13463837776DF367" modified="2018-10-10" version="1">MRTGSATHRGVYRENNEDSMIVAGTLCVVADGMGGHEAGEVASRLCVRQLAYSSFFTLPGGMSPEEQEDYERRVHDENKGKSNRRKTSELNNEILRTLERLRSLIGEANDQIKGALSKAGGTTVTGAWLTRIGSQQLWVIFNVGDSRTYRLVREQEGFHHSEMEMLPGNAGSASLEQVTADHSEVQYLVDEGQITQLEALTHPRRNVITRALGTGNYWEPDFWVFPAHEGDRVMLCSDGLSGELSHEYMARVLTSVRHPQDAADVLQYEALRSGGRDNITVIVADAIVPDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYF5</accession>
    <name>A0A2Z5QYF5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MerR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_03285</name>
        <name evidence="6" type="ORF">RA11412_1199</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87498">
        <property type="protein sequence ID" value="BAV87498"/>
        <property type="gene ID" value="RA11412_1199"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1199"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="267" mass="30660" checksum="971EF7915AB07780" modified="2018-10-10" version="1">MDAEKPQEYSVGEVAKMHGITVRTLHHWEQKGLITPEHDPVNGYRYYHDRDVEKVTAILGYRAIGMSLDTVRTIMNEGARNSVEHLLTQREMLHKKIRCYKHMLQTLDQLLEDAMAPTNERLTAAERAEIMGEAFNPEHEREAQQRYGHTDDWAEYRRRTDSMSRADWAAAKQNLDDVEHALVEAFTQGVKPGSAEANALADRHRASLFYFDVTPAKHVILARGYVEDARFAEHYEKLAEGLAQWLRDIITENARAYGVNPETVTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYG3</accession>
    <name>A0A2Z5QYG3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87393">
        <property type="protein sequence ID" value="BAV87393"/>
        <property type="gene ID" value="RA11412_1094"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1094"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="70" mass="7565" checksum="3015A4D7198546E1" modified="2018-10-10" version="1">MGLPEDMIPLGIVLVAASERPSTSQVFGELDEGRAAGRYPEDDTLIMPSGLLHTLTQNEAPIAHLHKIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYM2</accession>
    <name>A0A2Z5QYM2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anaerobic benzoate catabolism transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03005</name>
        <name evidence="4" type="ORF">NCTC10207_00675</name>
        <name evidence="2" type="ORF">RA11412_1268</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87567">
        <property type="protein sequence ID" value="BAV87567"/>
        <property type="gene ID" value="RA11412_1268"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1268"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="44"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI22594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="135" mass="15264" checksum="288CCA1172E9D5A5" modified="2018-10-10" version="1">MTKQRVSINGITRWKEVDATPKKAAPAVEEAKVVPLRQAIGEVLRDIRQRQGRTLREVSQRARVSLGYLSEVERGQKEASSELLAWICQALETPMYQMLREVADRMAILEGVHVPDTVPAELAEQYRNDYAMASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYM4</accession>
    <name>A0A2Z5QYM4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylneuraminate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87410">
        <property type="protein sequence ID" value="BAV87410"/>
        <property type="gene ID" value="RA11412_1111"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1111"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="229" mass="25403" checksum="D0DFADD6E4ABFF3F" modified="2018-10-10" version="1">MGFTTHLPDLFAGDFLVDLASRDLEVWERSIAEVQRTIDITRDLTRYFTVDEEPVMVVTMGGFTKDKHIPASARAAKYERIGEALGRLDTAGVRLAAQTLPPYPWLMGGQQYHNLFLDPQDTAEFARAYDSALCLDISHTMLACNFLKIPLSEAVAQLAPHSIHLHLVDGIGVDGEGVQVGEGDVDWAALGKQLRELAPKASFIPEIWQGHINNGEGFFTALDRLEKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYN8</accession>
    <name>A0A2Z5QYN8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Low molecular weight protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87401">
        <property type="protein sequence ID" value="BAV87401"/>
        <property type="gene ID" value="RA11412_1102"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1102"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="2">
        <location>
            <begin position="341"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="515" mass="55134" checksum="81587FDF6DF00223" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYR2</accession>
    <name>A0A2Z5QYR2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87450">
        <property type="protein sequence ID" value="BAV87450"/>
        <property type="gene ID" value="RA11412_1151"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1151"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="38" mass="4408" checksum="1A411E1E25D97AFF" modified="2018-10-10" version="1">MKWFSLVFSYVLSKTGPQRWVPKIVVNTEVPLDKTTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYR9</accession>
    <name>A0A2Z5QYR9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_1204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87503">
        <property type="protein sequence ID" value="BAV87503"/>
        <property type="gene ID" value="RA11412_1204"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1204"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="419" mass="47897" checksum="8FF22340E9D8C3E8" modified="2018-10-10" version="1">MELKENIRQQWWQRFVRSRADMVGLDSSVILPRPVWEASGHVATFMDPLVECLSCHRRQRQDHLIEAFEAKKGRAPENMGEVVCPNCGTRGEWTEPQNFSGLLKTYLGPVDNEEGLHFLRPETAQGIFVNFNNVVTAARKRPPFGIGQIGKAFRNEITPGNFIFRTREFEQMEIEYFVHPDEADKHFDAWVEDCWNWFVDLGINPENMRQFDVPEDDRAHYSAGTIDIEYRFGFQGGEWGELMGVANRTDYDLGVHNEHSNAKLEYFDQASGERYVPYVIEPSFGLTRSMMAFLVDAYVEDEAPNTKGGVDKRVVLKLDPRLAPVKAAVLPLSKKPELSGPAHKLAEELRGVWNIDYDEAGAIGRRYRRQDEIGTPFCITVDFDTLEDQAVTIRERDTMSQERVALDQVKAYLAARLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYW2</accession>
    <name>A0A2Z5QYW2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator gltC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gltC</name>
        <name evidence="4" type="ORF">I6I94_02600</name>
        <name evidence="5" type="ORF">NCTC10207_00768</name>
        <name evidence="3" type="ORF">RA11412_1366</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037236404.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87665">
        <property type="protein sequence ID" value="BAV87665"/>
        <property type="gene ID" value="RA11412_1366"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1366"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI22683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="299" mass="33218" checksum="99E5AF895032BA51" modified="2018-10-10" version="1">MYDIRRMQMLLEIHERGTIISAAHALNLTPSAVSQQITNLEKEAGTALLQRVGRRVQLTSAGLVVIETARRILREVDRMQTSVATLAGEPAGTVRLAIFQSASFALLPRTLAYLHDHAPRLVLQVLQIDPETGISMTRSREYDMVIAESYPHHYIPEYPELHSELLVEDPLSLIVPADSPIRSLHEARHIPWVLEREENTSRRWAVNQCRAAGFEPEIRYSANDMITNVNLVRAGFAASIVPGFILASLSNSEGLRVVDLPGAPYRSIFTAVRADAVTTPALAMVREAMRYAVSEAFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYZ8</accession>
    <name>A0A2Z5QYZ8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87511">
        <property type="protein sequence ID" value="BAV87511"/>
        <property type="gene ID" value="RA11412_1212"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1212"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="188" mass="20827" checksum="3B793462149038DE" modified="2018-10-10" version="1">MLIEALSLLPEHLNHVILDIAGGGELREELEKKAHDCGVSERVVFRGYVPDEDLPGVYQRADIFCQPGTAELQSLVSLEAMSASKPVVLANALALPHLVEDGVNGYLFEPNNARDLAHKLAAILSLPAAEREQMGRESRRIVDFHRADNTWRTFEELYVSDAPTTASATADAPIFLNPVRQVLWLRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ76</accession>
    <name>A0A2Z5QZ76_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_02220</name>
        <name evidence="2" type="ORF">RA11412_1463</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888890.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87762">
        <property type="protein sequence ID" value="BAV87762"/>
        <property type="gene ID" value="RA11412_1463"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1463"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="356" mass="38026" checksum="0BB876A093EBE776" modified="2018-10-10" version="1">MSDPQWKVIGASGFVGSSIVARLNAEGISADPIEAPRLATRATDPEIIIDEARRLEGIIDSLADAFAGAHVIVNAAGLAAPNMQDLPALVGANALLPAVIAIAAQRTGVRRMIHLSSAAVQGAKPVLDATEYTEPFSAYSFSKALGEECLLDLYDLIEETAAQGRAPGSANSPYPAAPSHAPAYVAPDHAVELCILRATSVQGRGRRTTELFAKMASSPFASVAGAGNRKSPVSSSYALAEFTVKLGRFPGQLPPIVLQPWEGATVNSIMTDAGRRAPKHLPEWLCRGAIKAGYTVSELLNDKFQGSVRKVELMWFGQELDDSWARANNLVPEPRVREVLRNAHTALGKKKDKRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ88</accession>
    <name>A0A2Z5QZ88_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein-N(5)-glutamine methyltransferase PrmC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_1459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87758">
        <property type="protein sequence ID" value="BAV87758"/>
        <property type="gene ID" value="RA11412_1459"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1459"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="5">
        <location>
            <begin position="37"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="4">
        <location>
            <begin position="155"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="281" mass="30277" checksum="951A6BC983162A64" modified="2018-10-10" version="1">MPRQCWQVDAMTRNMDMTDTTGTSLTPTQCEGVSLAQALRQGAATLRQAGVPSPVADAELLAAHLLGTDAEGNRRGTAREGYTRGAVQQRALLGDALTAQDMQRYESLIARRARRIPLQHITGVAAFHRIQVRVGPGVFVPRPETELLVEEALNALRAYPQRRLRVVDLCAGSGAIAAAIKNALPNDALVTAVELSEHAEPWARINCETYGVNFVHGDALSALEGLGGYFDAVVSNPPYIPQGRVPAEPEAAQHDPDMALYGGQRMGCGYRQRLLPGPHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZH7</accession>
    <name>A0A2Z5QZH7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87763">
        <property type="protein sequence ID" value="BAV87763"/>
        <property type="gene ID" value="RA11412_1464"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1464"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="304" mass="33102" checksum="660EF8EE38895F92" modified="2018-10-10" version="1">MNAEDARTIVAPNNAQHSDTLYRTVAVVVTYNRKDLLPLTLAGIARGEAQPAAVVVVDNASTDGTAQYLADLHYPLPLDVITLPRNMGGAGGFAAGIDRALAQHDPDLVWVMDDDTEPTENTLYEAVKAWEGYSPVRALRPALVASKVVWDDGRDHPMNTMRTMFAAGAERHARAKSVGARPIRSASFVSILMDAQVMRQNGGLPLTEFFIWNDDFEFSTRLAHHRDAIAVPSSVAVHHTKTFGTTDAKPGPRFYNDVRNKLWVLPGAALSAPWKSSSTAYPVPACGFPPWCVPMRKEPISGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZI4</accession>
    <name>A0A2Z5QZI4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87905">
        <property type="protein sequence ID" value="BAV87905"/>
        <property type="gene ID" value="RA11412_1606"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1606"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="209" mass="23947" checksum="6F321FCFB96B37BC" modified="2018-10-10" version="1">MSRTKRTQRGRRTELSEHQTLETRLEHYRREGKEHRMRTLIWGTVGSIMIMLGSYGSGWLADSSDFWRSSIIRTIRYDPSWIIACVVLVAAGGMIMCREWLRIYQKVGTDASSRRWIYAVIACWSTPQLFAFTLFSRDMFSYYGQGQVIANGLDPYKHGVSEITNFFQNGADPCGRSRPRRMGPSSLRSNSLLFGWPTVILTPPCLCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZN4</accession>
    <name>A0A2Z5QZN4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">ribH</name>
        <name evidence="9" type="ORF">I6I94_01620</name>
        <name evidence="10" type="ORF">NCTC10207_00967</name>
        <name evidence="8" type="ORF">RA11412_1633</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037237396.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87932">
        <property type="protein sequence ID" value="BAV87932"/>
        <property type="gene ID" value="RA11412_1633"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1633"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VEI22873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="157" mass="16147" checksum="143BA0B8B638F344" modified="2018-10-10" version="1">MSGAGAADTTLTPEDYRGFKLAIVAASWHTQVMDGLLDGARRAAADAGVEPTIVRVPGTFELPVAATRLAEKYDAIVALGVVIRGGTPHFDYVCQGATSGLTDVSVLTGRPVGFGVLTCDNEQQALDRAGLPGSSEDKGYEATAAALQTAATLKNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZU1</accession>
    <name>A0A2Z5QZU1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87780">
        <property type="protein sequence ID" value="BAV87780"/>
        <property type="gene ID" value="RA11412_1481"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1481"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="129" mass="14941" checksum="CCB2FD29FA7DD72A" modified="2018-10-10" version="1">MARKNHPGKRPSGTTSSKWLRTTAGGGRDISRILDPAPTVESDRYGDWFVQYIPAVNARKTYTCPECYRPIPPGTAHLVVWQESHVLGRERAIDERRHWHQHCWRSRRNNSRILCASPPFLGLRYTYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZX8</accession>
    <name>A0A2Z5QZX8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gap</name>
        <name evidence="12" type="synonym">gap_2</name>
        <name evidence="11" type="ORF">I6I94_01205</name>
        <name evidence="12" type="ORF">NCTC10207_01065</name>
        <name evidence="10" type="ORF">RA11412_1708</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887191.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88007">
        <property type="protein sequence ID" value="BAV88007"/>
        <property type="gene ID" value="RA11412_1708"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1708"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VEI22969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="334" mass="35880" checksum="AFF687A6C3728B72" modified="2018-10-10" version="1">MTVRVAINGFGRIGRTFFRAAREEGVGFEIVAINDLTNVDTLAHLLKYDSIMGRLDAEVEVKENALVVDGKEIKILAERNPADLPWKDLGVDVVLESTGFFTEGSKAQAHIDAGAKKVIISAPGKNIDGTFVMGVNDDQYDPATQHIVSNASCTTNCLAPLAKVLNDSFGIERGLMTTIHAYTADQRLQDAPHSDLRRARAAAVNMVPTSTGAAAAVGIVLPELKGKLDGFAVRVPTITGSITDLTFTTNREVTKEEVNAALKAAAEGPMKGIIKYSEDPIVSKDIEGEGISTIFDAPLTKVIGNQVKVIAWYDNEYGYVARLVMFTNKVVASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R063</accession>
    <name>A0A2Z5R063_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_1611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87910">
        <property type="protein sequence ID" value="BAV87910"/>
        <property type="gene ID" value="RA11412_1611"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1611"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="6">
        <location>
            <begin position="23"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="193" mass="21164" checksum="6147D8ACF6E2B970" modified="2018-10-10" version="1">MDSAENSAVPSTRRHLKRGWRLVAVALGIAVVTLLCVRTFLVDVYYIPSESMEPAYTPGDRVLVSKLEGAGAVQRGDVVVFDGTGSFAPYESGSSFWKDPAKSIGQWLGFVPTDTVYIKRVIAVAGDRLSCCSDNGKLVLNGQELDEPYLYPQDSPSETRFDVVIPHSRVWVMGDHRSASVDSRSCWEHPVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0B9</accession>
    <name>A0A2Z5R0B9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase PriA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88167">
        <property type="protein sequence ID" value="BAV88167"/>
        <property type="gene ID" value="RA11412_1868"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1868"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="525" mass="55447" checksum="BC83DDB3EC8A6145" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0F4</accession>
    <name>A0A2Z5R0F4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6493 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88031">
        <property type="protein sequence ID" value="BAV88031"/>
        <property type="gene ID" value="RA11412_1732"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1732"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="164"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="331" mass="37513" checksum="A4613F713EE9ED72" modified="2018-10-10" version="1">MQDSQQNTFTSAQRLTQLAVLVDYDAPMEELQKTVGGADEKERAILAKVLERTELLDSHGAPRPGAFYILGALGTAEQAAYILRCTLWHLEHEKFSTALSSFTTGARERPDEWVLGFSNNPLTINYWDAIRPILRERGLKNTSVSALLGFRESIPVVTGESSRGQKDVLEFFARNPELLEHDFWELFWVDGLLYETYGHGRGDTVALVRLLTSHYAGFRDRVLDECLAAMRRDFRETRIFWVLYRGLEPTTAENLRRLPQLLAVLEAPQSALISFALDTLAGTVPAMNTEQAASLVDASHAVLYRTEKKVLRAQLRVLRKVVKHTRNLRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0K1</accession>
    <name>A0A2Z5R0K1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fe-S cluster assembly ATPase SufC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Iron-sulfur cluster assembly ATPase protein SufC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Vegetative protein 296</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yurY</name>
        <name evidence="7" type="synonym">sufC</name>
        <name evidence="7" type="ORF">I6I94_01060</name>
        <name evidence="8" type="ORF">NCTC10207_01094</name>
        <name evidence="6" type="ORF">RA11412_1761</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887263.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88060">
        <property type="protein sequence ID" value="BAV88060"/>
        <property type="gene ID" value="RA11412_1761"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1761"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI22998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="252" mass="27695" checksum="0334E21D31A4A0FC" modified="2018-10-10" version="1">MSTLEIKDLHVSVILDDENTKPILKGVNLTIKSGEIHAIMGPNGSGKSTLASTIAGHPKYQIDSGQILLDGEDITEMSVDERARAGLFLAMQYPVEIPGVTMSNFLRSAKTAVDGKAPNLRTWTKDVKAAMEQLKIDPTFVSRNVNEGFSGGEKKRHEILQLELLKPKFGILDETDSGLDVDALKVVSEGVNRAHESNDMGVMLITHYTRILRYIKPQFVHVFVDGKMADQGGPELADRLEEEGYVAYTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0M1</accession>
    <name>A0A2Z5R0M1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88034">
        <property type="protein sequence ID" value="BAV88034"/>
        <property type="gene ID" value="RA11412_1735"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1735"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="350"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="572" mass="63375" checksum="440129540650CADB" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0R2</accession>
    <name>A0A2Z5R0R2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="16" type="ORF">I6I94_00355</name>
        <name evidence="15" type="ORF">RA11412_1934</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88233">
        <property type="protein sequence ID" value="BAV88233"/>
        <property type="gene ID" value="RA11412_1934"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1934"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV88233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QQT89131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="281" mass="30523" checksum="5AE55759782FAF63" modified="2018-10-10" version="1">MLEGVEWIQAIILGLVQGLTEFLPISSSAHLRIVGQLLPEKADPGAAFTAITQLGTETAVLLYFWRDIVRILSAWFGSLTGRVKRSNPDARMGWLIIIGSIPIGILGLVLEDYIDSTFRSLWIVGTMLIVFAVFLGLADRFGKEQRKIKDLTLGHGLVYGCAQALALIPGVSRSGGTIMAGLFMGYTREAAARYSFLLALPAVFTSGLYKAFKVFTGHEAGGYYGIPSTLLATVIAFGVGYLMIAWFLKYVSSNSYGLFVWYRILLAALIFLGLGFGVISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0S2</accession>
    <name>A0A2Z5R0S2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PhoH family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Phosphate starvation-inducible protein PhoH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_00325</name>
        <name evidence="5" type="ORF">RA11412_1944</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88243">
        <property type="protein sequence ID" value="BAV88243"/>
        <property type="gene ID" value="RA11412_1944"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1944"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="4">
        <location>
            <begin position="116"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="373" mass="40548" checksum="658FECD199B81DF7" modified="2018-10-10" version="1">MTTTSRPLSTARTVSFKSAAEMVAVLGPQDAYLSLIEDYFESISVHPKGLDLLITGPSESVNTAAKLLNELRVLASHDTQITVQVIHRLMGMLTDELKDPARSLSASILSTRGTTIRPKTINQKKYVDAIDTNTVIFGIGPAGTGKTYLAMAKAVQALQSREVNRIILTRPAVEAGERLGFLPGTLNDKIDPYLRPLYDALHDMLEPETIPKLMEAGTIEVAPLAYMRGRTLNDAFIILDEAQNTTAEQMKMFLTRLGFGSKMVITGDVTQVDLPGGQASGLKQVRNILEGVEDIQFCVLESSDVVRHALVSNIVSAYDRWGEDQKAMERKRNRKVKRATIEAAAEKLLDRAGINGDAPAGAGRETPGTGKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0T8</accession>
    <name>A0A2Z5R0T8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88263">
        <property type="protein sequence ID" value="BAV88263"/>
        <property type="gene ID" value="RA11412_1964"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1964"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="45" mass="4984" checksum="C2FB4918FF86EAC6" modified="2018-10-10" version="1">MRIKGVSNVLLLMHERSPSAAVDAPDKNTIVARQNPRMRVTIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Y1</accession>
    <name>A0A2Z5R0Y1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88200">
        <property type="protein sequence ID" value="BAV88200"/>
        <property type="gene ID" value="RA11412_1901"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1901"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="147" mass="16099" checksum="E825DE9BD9656021" modified="2018-10-10" version="1">MHHAFTAPKPEFLDTFDKDPGSALAYAYDIVCNGNEIGGGSIRIHRRDVQERVFAVMGIGEEEAQEKFGFLLDAFKYGAPPMGGIAFGWDRIISLLAGVDSIREVIAFPKTGNGYDPLTAAPAPITPQQRKEAGVDFKPKKKDEDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Y7</accession>
    <name>A0A2Z5R0Y7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00645</name>
        <name evidence="2" type="ORF">RA11412_1867</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88166">
        <property type="protein sequence ID" value="BAV88166"/>
        <property type="gene ID" value="RA11412_1867"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1867"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA_ligase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="268" mass="30798" checksum="8E184BA86E5594B2" modified="2018-10-10" version="1">MIANTEPQKYARSLHAPISLGTTSDDRFMPRGYLAHFATLQQLVLTEKLDGQNNCFAAHGLYARSHAAPTQHPWDKPLLQRWQHIKDDLGDLELFGENMYGIHSIAYSQLESYFYLFAVRRGGHWLSWEEVKFYAQLFDFPTVPELPIVHPLADFTQKYTDEDIALEQWLLANLGATWTDSVQTAGKLGGYDPKTGEACSEGFVIRNAADFATNNGNLPVQSNEFDNLFKLVRAKHVKTDVHWTKTWKPARLIDYDKYHWQSWQFQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Z6</accession>
    <name>A0A2Z5R0Z6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86549">
        <property type="protein sequence ID" value="BAV86549"/>
        <property type="gene ID" value="RA11412_0250"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0250"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="61" mass="7116" checksum="A062C16DC69A0066" modified="2018-10-10" version="1">MTEDVTDKKKGGYFMKGLDGKKTPLNKKKAQEIFNNIDKTETVFVDMNHKFQATRMTFSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R130</accession>
    <name>A0A2Z5R130_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">secF</name>
        <name evidence="12" type="ORF">I6I94_00460</name>
        <name evidence="11" type="ORF">RA11412_1907</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887160.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88206">
        <property type="protein sequence ID" value="BAV88206"/>
        <property type="gene ID" value="RA11412_1907"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1907"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV88206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT89147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="363" mass="39574" checksum="6C8ED2185A2ADB22" modified="2018-10-10" version="1">MTEVKPNVFARFGNDLHSGKRSYPFIGKRKLWLMIAAALMAVSVILPLVGNGFNLGIDFRGGSEFVVSKASHTESSTGEKIVKENVPDASDVHVTHIAPGTVRAQMSKLSDEETLKVKKALQDAYGVSENDVTSSYVGPTWGADVTRQALWGLVAFVIFALIGMAFYFRTWKMSVASIAGLFFTVVVTVGIYAALGFEITPSAIIGFLTILSYSLYDSVVVFDKIRENTEDIMDRKDATFAEETNLAVNQTLVRSINTAIVGVLPVGSILFIGAFMLGAGTLQDLSLSLFVGILVGMFGTLFVSAPLYGMLRLGEKKIVGQRQKVEYFRAHGGEEETDSDNESQQKPVKRSKPKIEVNVVNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R168</accession>
    <name>A0A2Z5R168_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86629">
        <property type="protein sequence ID" value="BAV86629"/>
        <property type="gene ID" value="RA11412_0330"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0330"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="96" mass="10866" checksum="A98079AE30260779" modified="2018-10-10" version="1">MVETYRKITDEAGANTHRALPETTSYTLQTALSTYLPNLFTAYTRTHSPTETQTTELVQALTEANREFSTALNLVRAGHSMDLETHTLFMRKRMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R186</accession>
    <name>A0A2Z5R186_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86649">
        <property type="protein sequence ID" value="BAV86649"/>
        <property type="gene ID" value="RA11412_0350"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0350"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="57" mass="5894" checksum="5AB356D778059D21" modified="2018-10-10" version="1">MRQQQPGLPPVQALALLVPVVLLVLAAGEQLVALAEAAVEWRLPVALAVEAAEAAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1D4</accession>
    <name>A0A2Z5R1D4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88595">
        <property type="protein sequence ID" value="BAV88595"/>
        <property type="gene ID" value="RA11412_2296"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2296"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="123" mass="13386" checksum="81A6D4358AD4A929" modified="2018-10-10" version="1">MESVGDGWVQVNAMGESVILPLQGVLWWEGSELALRADVRQKVYRLTLPLALRALATSRELVKIYMAHGGVVCEGVIERVGADFVELKVLTGGEYPRSDSWRGAQKGVRIIPTPLIGAVVARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1I3</accession>
    <name>A0A2Z5R1I3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1963 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_10575</name>
        <name evidence="1" type="ORF">RA11412_2223</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88522">
        <property type="protein sequence ID" value="BAV88522"/>
        <property type="gene ID" value="RA11412_2223"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2223"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015315">
        <property type="entry name" value="DUF1963"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035948">
        <property type="entry name" value="YwqG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09234">
        <property type="entry name" value="DUF1963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103032">
        <property type="entry name" value="SSF103032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="287" mass="31994" checksum="F3B920FF87D68539" modified="2018-10-10" version="1">MGRTVAKEARKIAAEITAATRQPVIRIKTAGAKAPLPVTASKFGGAPYLPAGAQAPTNESGKPLGMIAQINCTELPKNELYPKTGILQFWIDSGEEEGDENWGFNANDIANQANIRVIYYPQVGEATPAGHPAVTAARSEDWPIYPPEAELALTFKKKHESLSDTSREFEARFVHRWNEKHPEQTINEVYEIDRLHDGENIAYDLTDSTEYHKLGGYPSFVQDDPRENNPELQEYTVNLLTIASEEAKNDGDGDIMWGDMGTANWLITPEQLKNRDFSKVLFEWNCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1I5</accession>
    <name>A0A2Z5R1I5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6318 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_10990</name>
        <name evidence="4" type="ORF">RA11412_2111</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88410">
        <property type="protein sequence ID" value="BAV88410"/>
        <property type="gene ID" value="RA11412_2111"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2111"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046281">
        <property type="entry name" value="DUF6318"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19843">
        <property type="entry name" value="DUF6318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033777419" description="DUF6318 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6318" evidence="3">
        <location>
            <begin position="86"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="269" mass="28659" checksum="F3EC91F951D6F0C2" modified="2018-10-10" version="1">MIRSAVASRRIFLVGAASSLGAAALSACGSSSSSRTAGNAGVPAGGSSVQATTADTRENLSGELLWQHYRSAGPQPSAGSTAAPTGNPASLQSKATDVPVPTEYDYMRDEDTSGLRFTFAYYIAALNYARATGDMKPALKVVHPQNQPAIAQLQGYEQLYMSTTQWIVGGSWTVSLTEKQPDEKGYKYAWACSVKQESGVLVNAAANTNTVLPTEEARAMRTLYGMWEGEQWWIISAEQYDPSASPRRTALPQVTPTVPAKVVTVPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1I8</accession>
    <name>A0A2Z5R1I8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88523">
        <property type="protein sequence ID" value="BAV88523"/>
        <property type="gene ID" value="RA11412_2224"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2224"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015315">
        <property type="entry name" value="DUF1963"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035948">
        <property type="entry name" value="YwqG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09234">
        <property type="entry name" value="DUF1963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103032">
        <property type="entry name" value="SSF103032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="84" mass="9835" checksum="925A9B6D486297F3" modified="2018-10-10" version="1">MFYRDIAQGSYHKLGGHPEFTQQDPRQEHDGFDNYTINLLTMFSEDAEKFVTVWGDQGTANWLITPEQLKNRDFSKVLFEWSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1N6</accession>
    <name>A0A2Z5R1N6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HRDC domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Ribonuclease D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_10745</name>
        <name evidence="2" type="ORF">RA11412_2171</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88470">
        <property type="protein sequence ID" value="BAV88470"/>
        <property type="gene ID" value="RA11412_2171"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2171"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041605">
        <property type="entry name" value="Exo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18305">
        <property type="entry name" value="DNA_pol_A_exoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="1">
        <location>
            <begin position="223"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT90170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="403" mass="45740" checksum="6097C3A0C81CE452" modified="2018-10-10" version="1">MVPEVVPLDSPSVPIPPVIDTERALHRAADELAGASGPVAVDTERAQGIRYGRRAFLVQLKRDNKIYLIDPEAFKDLRIINDALTDAEWVIHAAIQDFPSLDMLGMRPKHLFDTELGARLAGMERVNLGAVVEELLGYRLAKKHSKEDWSTRPLPKNWLNYASLDVDVLIDLRDAVEELLDSQGKLGIAREEFAHLCLMPAFDEQQYRAERWRKTKGRNELRSVRQLTALRNLWFERDKLAQKKDIDSKRLLSDAALVAAAKTMPHTVPGILEIPGFQTRLLKREAPRWVRAITDAARDHDPVPYSTPSSAPPPLKAWETKRPESLAIFTEVREVINALSERLDIPAQNIINTEYARRLCWEPPEPYSQDALAAALYECGARQWQVQLLAPQMHQIFVAHLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1R5</accession>
    <name>A0A2Z5R1R5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88464">
        <property type="protein sequence ID" value="BAV88464"/>
        <property type="gene ID" value="RA11412_2165"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2165"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018764">
        <property type="entry name" value="Anti-sigma_K_RskA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10099">
        <property type="entry name" value="RskA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="93" mass="9808" checksum="2F904AAEA1444A7E" modified="2018-10-10" version="1">MPVSVMYSPSHNMAGVSTTNLPALPEGKVYKLWLYDAQGTIVGSGTLNSAGRGAGVTTMTEHDLSRVTDFGISIEDESAHSPSQKPAMLENVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1W4</accession>
    <name>A0A2Z5R1W4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86879">
        <property type="protein sequence ID" value="BAV86879"/>
        <property type="gene ID" value="RA11412_0580"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0580"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="70" mass="7622" checksum="DF4F10B69F9AECEB" modified="2018-10-10" version="1">MTIERLSIFTAGHMSYHPIKGAVSTSRERAEPNYIPLKNHSVALENANTATPVLLSIPAEAACSIARRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Y3</accession>
    <name>A0A2Z5R1Y3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88486">
        <property type="protein sequence ID" value="BAV88486"/>
        <property type="gene ID" value="RA11412_2187"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2187"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="52" mass="5538" checksum="F5CD9D6FDAA1D316" modified="2018-10-10" version="1">MEAAAGETKRPFEYFRAAVSAPDSRAVPLATLTAGCSPEGWGASRRFLSHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R219</accession>
    <name>A0A2Z5R219_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_2311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88610">
        <property type="protein sequence ID" value="BAV88610"/>
        <property type="gene ID" value="RA11412_2311"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2311"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="27"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="271" mass="28867" checksum="8589C8530EC1917F" modified="2018-10-10" version="1">MSENAYRIAVLTKYVPDTQFEQKLDDTLRVDRSESVMSELDEYAVEAAVQIVEAEDTDAANSAVIAFTLGAADASKGLRRALQLGAHEGVHILDDAFAGADALATSRIIAAALSTYEQEHGTFDLILTGMASTEGETSLVPVQVSELLGRTGISQVASLSVAGRTVRAHRDLDTRSQHCETELPALISVTDQVNTPRYPNFKALMAAKKKPITTVNAADIADELAKFGGSASTVTVTEAQAREERTAGETIVDEGDGGIQLVEFLASRNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R243</accession>
    <name>A0A2Z5R243_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_2331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88630">
        <property type="protein sequence ID" value="BAV88630"/>
        <property type="gene ID" value="RA11412_2331"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2331"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="9">
        <location>
            <begin position="168"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="373" mass="41978" checksum="FE62829A2A613BE6" modified="2018-10-10" version="1">MKISAHQRPARSGVRPQIVQRLLTPAAWADQNPQQGSVLTALWPFDPLDGPAVWRWESDEALTEGMRAQLRYGAQSDDAHPAELSEQQQGPAVNRPQQVSVPGDRRARVERAALNVARGGIELAPGANAPQADAHTRQEIQDWEQEVELLLALARRAVTPAAPSKPEHLSASELMSLAENPQQARARMVRPVPVQPSAAARAGTFFHEWVENHFGADPMLDLDDELYTDDETDTTLSLDALRKTFLASEWANRTIWRAEYPVETHVAGVSVRGRIDAVFRTVERTEQGQRERWELVDWKTGRKPTAKQMRYKRIQLALYRLAFAKIQCVDPADVRAAFYYVGSDQTVWDSDIAGGLQSEAQLERIITRWDWEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R289</accession>
    <name>A0A2Z5R289_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87009">
        <property type="protein sequence ID" value="BAV87009"/>
        <property type="gene ID" value="RA11412_0710"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0710"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="3">
        <location>
            <begin position="25"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="327" mass="34222" checksum="5CB16BE8A5E479A8" modified="2018-10-10" version="1">MNHARNDEPAAPAHLPCDAAAAERTLVMGILNVTPDSFSDGGEHYTANDALAHAQRMIAQGADIIDVGGESTRPGAVRISVEEELRRILPVIEGLAETGITISVDTMNAATARAAVAAGAHIINDVSGMSVSDEMIQTVAELGVPYILMHARGTSTTMDALAAYPRGTVTEVLDELAALRDRLVAAGVHGENIILDPGLGFAKGGMQDWELLAALGQLHALGHRVLIAGSRKRFLANALNAADAARTKTQNPAAGANTAPDQMPPARAPEDRDAASAALSALVAAQGVWGFGCTMCPHGGCRDRSEYFTHCYPHQTDLKLCTSIHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2A9</accession>
    <name>A0A2Z5R2A9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_2391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88690">
        <property type="protein sequence ID" value="BAV88690"/>
        <property type="gene ID" value="RA11412_2391"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2391"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="95" mass="10367" checksum="936CB51ABAC03D51" modified="2018-10-10" version="1">MKDRACVEECPVDCIYEGDRTLYIHPDECVDCGACEPVCPVEAIYYEDDVPEEWSEYITANAEFFDDLGSPGGAAKMGPTGKDVPFIAALPPQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2B7</accession>
    <name>A0A2Z5R2B7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal RNA large subunit methyltransferase N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_2544</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88843">
        <property type="protein sequence ID" value="BAV88843"/>
        <property type="gene ID" value="RA11412_2544"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2544"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="153" mass="17314" checksum="A4B2AAD5D02DBB99" modified="2018-10-10" version="1">MGLVPGIRKFELEKLPITLALSLHAPDDELRDELIPINQRWKVDETLDAAYDYYRTTGRRISIEYALIRDINDQGWRADLLGKKLAQRGRGWVHVNPIPLNPTPGSKWTASRKGVEQNFVERLRAHGIPTTIRDTRGSDIDGACGQLAAKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2D0</accession>
    <name>A0A2Z5R2D0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88878">
        <property type="protein sequence ID" value="BAV88878"/>
        <property type="gene ID" value="RA11412_2579"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2579"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="10"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="414" mass="45586" checksum="4F8E14BC9B4D4199" modified="2018-10-10" version="1">MAHDVYTDLNKVRNIGIMAHIDAGKTTTTERILFYTGINHKIGETHDGASTMDWMAQEQERGITITSAAITCFWKNNQINIIDTPGHVDFTVEVERSLRVLDGAVAVFDGKEGVEPQSETVWRQADKYDVPRICFVNKMDKMGADFYFTVQTIIDRLGAKPLVLQLPIGAESDFVGVVDLLEMKAYVWPGDSKGDVTMGASYEIQEIPADLQAKAEEYRAEMVEAVAESSEELMEKYLEEGELTVDELKSGIRQLTINGEAFPVLCGSAFKNRGVQPMLDAVIEYLPSPLDVPAVEGSSPSDEEEKLTRKASADEPFAALAYKVAAHPFYGQLIYTRVYSGHASQGQQVLNSTKGKKERLGKLFQMQSNKENPVEEVTAGHIYAAIGLKDTTTGDTLCDPANPIVLESMTFPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2J5</accession>
    <name>A0A2Z5R2J5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88948">
        <property type="protein sequence ID" value="BAV88948"/>
        <property type="gene ID" value="RA11412_2649"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2649"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="214" mass="23838" checksum="3D91E96FF0C6540F" modified="2018-10-10" version="1">MDFTTDPTTARITSSFTIMFDMRREGMRLQAVSNLMWEPYAYDEEGVIAEAAIGPDLEFTWTVRDRLPERARLIEAIFESVYSSFHVTPVVLAEGHHFYKEQTLSTGEQALEEIHLCVNSSITRLFITDSWDVEEPEGKRVTGGYAATIMNHGGYDGVLTWSTPEDARYTFAPDIVPYEAPLSGDALPQKIQAILPYLPAAPGASLTEHGTGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2L8</accession>
    <name>A0A2Z5R2L8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Heme ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_04645</name>
        <name evidence="4" type="ORF">RA11412_0840</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87139">
        <property type="protein sequence ID" value="BAV87139"/>
        <property type="gene ID" value="RA11412_0840"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0840"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340124" evidence="2">
        <location>
            <begin position="46"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="123"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="387" mass="40656" checksum="2E16B95C98BD547C" modified="2018-10-10" version="1">MFIHSLVSGIKAPSCFSQKIAALMMAALLFTLSACGIGTQNPNNAASSQTIVSEEQSSAVLAELAQQLKDGKAAHPKEVTGPSSAKNTPEVQAMVDTPTPQLPVTFKDYTGKEVTVKSAERILALDTYGTLTQDVIALGLGGRLVGRTVSNTEQSLSKLPVMTQNGHDLNVEAILSAKPDVVFLDSSASSRDAAQKLESSGITVVLTDTNRKMNLIIPQLKLVAQALGVQEAGNTVAERIQKDLDYATTTLKEVAPQGDQRLSMAFLYVRGNSGVFFVLGDGYGADELITAVGGRGVAAENGIKEMTMANAEALVKLNPDLILVMSRGLKSTGGVDGLVSRPGVEQTTAGKNRRIVDMDDGQILSFGPNTPAVLLSLAKAIYAPEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2M8</accession>
    <name>A0A2Z5R2M8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88711">
        <property type="protein sequence ID" value="BAV88711"/>
        <property type="gene ID" value="RA11412_2412"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2412"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="174" mass="18126" checksum="9783C894BF3B4D92" modified="2018-10-10" version="1">MVTIPAADGGGSSSNGNRVVQNVPAQAHAKAGTTGVPTGVQSWATDKHGAVSFLTPTGNIGCDVISGDSMVVCMLKESQWTEKVDSPGIDPKTGKPVQRRAFQLQLKADGSSQVTAPGGVNGAMGNRSSTKTLQYGQMLHVGTFVCASEQNGVTCWNHTTGHGVFLNRTEHITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2P9</accession>
    <name>A0A2Z5R2P9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II toxin-antitoxin system VapB family antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_09685</name>
        <name evidence="1" type="ORF">RA11412_2437</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887478.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88736">
        <property type="protein sequence ID" value="BAV88736"/>
        <property type="gene ID" value="RA11412_2437"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2437"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019239">
        <property type="entry name" value="VapB_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09957">
        <property type="entry name" value="VapB_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="65" mass="7097" checksum="51B2A17CDF9D3E40" modified="2018-10-10" version="1">MRTTVTLDEEIVAKAVKLTGIEERSVLVREAMETLVRIENGRLLAALGGSDPQAQAAPRHRNVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2R3</accession>
    <name>A0A2Z5R2R3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Threonine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_08330</name>
        <name evidence="4" type="ORF">RA11412_2756</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89055">
        <property type="protein sequence ID" value="BAV89055"/>
        <property type="gene ID" value="RA11412_2756"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2756"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031640">
        <property type="entry name" value="Glu_dehyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16912">
        <property type="entry name" value="Glu_dehyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="25"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Glu_dehyd_C" evidence="3">
        <location>
            <begin position="174"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV89055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="339" mass="36313" checksum="C63EE468AFC5FFF4" modified="2018-10-10" version="1">MKASFITGIRSAEAREIEDAHPQQPDEALIRVAHAGICGTDLELYDGTSNYLRRGLTEYPHHYGHEWVGVIETPPQTVHGTQLKPGAVVTGSTMIPCLICDFCQRGRRNLCTNLREVGLYEHGGAAAQKLVMPAHVLTVIDDGPGAEPHPEYILIEPLVTVLEGLAKATPEPGDRVLVLGGGTIGTLAALVLKQYPVEVAVVDPSQPVHLAELGIRAYKTVDSLPSGDWDAVWECSGSGTALQATPSLLRNGGAAVLIGFPPAQTGLDASELALRGQHLVGVRHGIDHYAAAAQFVREHRDKLGALIDSSYSLNDAQAAFERLEAGERERPKVMLSIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2R4</accession>
    <name>A0A2Z5R2R4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylamine utilization protein MauE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I6I94_08320</name>
        <name evidence="14" type="ORF">RA11412_2758</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; methylamine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89057">
        <property type="protein sequence ID" value="BAV89057"/>
        <property type="gene ID" value="RA11412_2758"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2758"/>
    <dbReference type="UniPathway" id="UPA00895"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030416">
        <property type="term" value="P:methylamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009908">
        <property type="entry name" value="Methylamine_util_MauE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07291">
        <property type="entry name" value="MauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340117" description="Methylamine utilization protein MauE" evidence="12">
        <location>
            <begin position="24"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="MauE" evidence="13">
        <location>
            <begin position="11"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="337"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="385"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV89057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QQT88528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="702" mass="72112" checksum="04B4FECB62F8129A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2R6</accession>
    <name>A0A2Z5R2R6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rpsM</name>
        <name evidence="9" type="ORF">I6I94_09230</name>
        <name evidence="10" type="ORF">NCTC10207_01755</name>
        <name evidence="8" type="ORF">RA11412_2541</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005505026.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88840">
        <property type="protein sequence ID" value="BAV88840"/>
        <property type="gene ID" value="RA11412_2541"/>
    </dbReference>
    <dbReference type="GeneID" id="29744298"/>
    <dbReference type="GeneID" id="61436394"/>
    <dbReference type="KEGG" id="raj:RA11412_2541"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VEI23827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="122" mass="13718" checksum="2EDE7C61ED58C2DD" modified="2018-10-10" version="1">MARLAGVDIPREKRVEVALTYIYGVGKTRAHETLAATGVNPDTRVKDLTDQELVALRDFIEGNYKVEGDLRREVAADIRRKVEIGSYQGLRHRRGLPVHGQRTKTNARTRKGPKRTVAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2W2</accession>
    <name>A0A2Z5R2W2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate racemase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Aspartate/glutamate racemase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09445</name>
        <name evidence="2" type="ORF">RA11412_2492</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88791">
        <property type="protein sequence ID" value="BAV88791"/>
        <property type="gene ID" value="RA11412_2492"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2492"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004380">
        <property type="entry name" value="Asp_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF7">
        <property type="entry name" value="PTHR21198:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00035">
        <property type="entry name" value="asp_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="234" mass="25033" checksum="89277EB417A8D0EE" modified="2018-10-10" version="1">MKTLGIIGGMSPESTALYYRIINREVNRRLGGNHSADIVMHSVDFEEVVRLQKSGDWEVAGALLAASATKLEGAGAQLLLVATNTMHKVAPAIERATTVPLLHVVDATATAIQRQGLQRVGLLGTTFTMSDGFYTERMAAQGIQTIVPTEPEQAETSRIIFEQLCLGRVEPESVQYLQQVITGLKEQGAQGVILGCTELCLAVEADKTPLPVFDSTTIHALAAVEAMLTPPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Z3</accession>
    <name>A0A2Z5R2Z3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08885</name>
        <name evidence="4" type="ORF">NCTC10207_01825</name>
        <name evidence="2" type="ORF">RA11412_2621</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887726.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88920">
        <property type="protein sequence ID" value="BAV88920"/>
        <property type="gene ID" value="RA11412_2621"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2621"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI23959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="184" mass="20756" checksum="15185F98DF9D5642" modified="2018-10-10" version="1">MSYELITTSKTKNRHINYRKLSDVLYGVVHWWGDDKGKSFDETVNFLCNNDRKVSANYVVEAGRVAQIADDQDVALHAGQWEVNEVSIGLENRPDCRSEDLDTLAQLIADIEVRLGHSLYLIGHRDIISTSCPGEYYPHLPELIHRVNTIKAGMNNAPAALTAQERADRLAKLQELKQKKKQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R318</accession>
    <name>A0A2Z5R318_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88944">
        <property type="protein sequence ID" value="BAV88944"/>
        <property type="gene ID" value="RA11412_2645"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2645"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011534">
        <property type="entry name" value="Asp_ADH_gamma-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46278:SF4">
        <property type="entry name" value="PTHR46278:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="1">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Semialdhyde_dhC" evidence="2">
        <location>
            <begin position="75"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="191" mass="20795" checksum="68BB366FA1522244" modified="2018-10-10" version="1">MTAQGGDYTKEVHPKLRESGWEGLWIDAASALRMNDDAIIVLDPINRDVIDRGLESGVKDFIGGNCTVSCLLMGLGGLFKQGLVEWTTSMTYQAASGGGARHMREVLGQFRDLGNEVSAELNDPAAAILEIDRKVLAKQRSGELDTAQFGVPLSGSLIPWIDSDLGNGQSREEWKSDAETNKFWVLRAITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R394</accession>
    <name>A0A2Z5R394_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88996">
        <property type="protein sequence ID" value="BAV88996"/>
        <property type="gene ID" value="RA11412_2697"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2697"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="85" mass="9316" checksum="ED5F6C56DD7A7921" modified="2018-10-10" version="1">MNLPLFAEPSSGARGGRTSIPHYVELLGMDARSELGAQIERVVLLGIPRSHGQSVPCWGGKASRRRTTRRVKPAGMSREHAPRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3A3</accession>
    <name>A0A2Z5R3A3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89016">
        <property type="protein sequence ID" value="BAV89016"/>
        <property type="gene ID" value="RA11412_2717"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2717"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="292" mass="31489" checksum="90E091314FAE6F4D" modified="2018-10-10" version="1">MPAVSEAHGKSVDEAKRLRRLKSALGRLNGVVPAGGGSTPSVAARLNAVDELAALADEWLADTSVEEQERNRRAQSVITALCDYLRSPANDCDTAPADAAHLSAAGRIHTHTLDTIRQHVRWRENPHPAEPMHAELSTREGAHPLAAELNQPPKPGAVLPGPWSHLAFNFSNAVFYDVVDLGEAYWAGPVTFDGAVFTHDAYFATRCTVRTWCLAVVNTADMSCSQTLPTVVRRLLQNRPTTILYIFPIQCMRGARFLPAPTTVQQPTTGAASTTRGQTSAAAHTTARSPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3A6</accession>
    <name>A0A2Z5R3A6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin carboxylase of acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87459">
        <property type="protein sequence ID" value="BAV87459"/>
        <property type="gene ID" value="RA11412_1160"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1160"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="40" mass="4126" checksum="D636AEAAAB08740A" modified="2018-10-10" version="1">MLEAMKMEQPITAHKAGKVSGLSLKAGDTVTAGQVLATIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3D3</accession>
    <name>A0A2Z5R3D3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89096">
        <property type="protein sequence ID" value="BAV89096"/>
        <property type="gene ID" value="RA11412_2797"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2797"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="60" mass="6844" checksum="DD6D1EC974ACB339" modified="2018-10-10" version="1">MTIDLADLYCPEGTCQPIIGNVYVYMDDNHVTKSYARTMAHAIYERASRSGWLVTGRLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3P0</accession>
    <name>A0A2Z5R3P0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">sepF</name>
        <name evidence="8" type="ORF">I6I94_02440</name>
        <name evidence="9" type="ORF">NCTC10207_00800</name>
        <name evidence="7" type="ORF">RA11412_1410</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87709">
        <property type="protein sequence ID" value="BAV87709"/>
        <property type="gene ID" value="RA11412_1410"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1410"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VEI22715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="229" mass="25234" checksum="716B3067A3CF5180" modified="2018-10-10" version="1">MAKQGGGIARITSFFGVAEYEGAHEHQGNSEAEGAATSAQPEESSARLNALPTPLDGGHKRRYARQESSAAADRGYDNSADNHWEDDTVQDNAEVEYTQDQYGYEDGELAEEYPEDYGADDYPSEEEEDELRRITTIHPRSYNDAKIIGEAFREDIPVIMNVDDMPDADAKRLVDFASGLVFALNGRIERVTAKVFLLTPSDLEVLGITSSDDMPQAFDDEGLVPFDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3T5</accession>
    <name>A0A2Z5R3T5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87959">
        <property type="protein sequence ID" value="BAV87959"/>
        <property type="gene ID" value="RA11412_1660"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1660"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="59" mass="6590" checksum="E79BBB0090A02B00" modified="2018-10-10" version="1">MNTVEQIFELWHSYAQERNTEGLLSLYAEDAVFESPLVPAILDDARSGVLHGKKRLSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R470</accession>
    <name>A0A2Z5R470_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DSBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88339">
        <property type="protein sequence ID" value="BAV88339"/>
        <property type="gene ID" value="RA11412_2040"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2040"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="219" mass="24068" checksum="7345606B1CA98330" modified="2018-10-10" version="1">MTTTVDFWFDPICPWCWITSRWIGEVQKVRDIQVRWHPFSLSVLNEGRDLDPGYRAMMDNAWGPARVVAAAAQLHGNDALKPLYDALGEQIHHQKNTAQGDKYLPAIEAALAEAKLPAELVNYATTDEYDEPLRASVAQALEKVGDDVGVPLIAIDGVAFFGPVLSPSPRGKRPVKCSMAPWRWPHTRGSLSSNAPARSGLSSTAKTVTPSSHTTVFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4V6</accession>
    <name>A0A2Z5R4V6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MogA/MoaB family molybdenum cofactor biosynthesis protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor biosynthesis protein MoaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08985</name>
        <name evidence="2" type="ORF">RA11412_2600</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887785.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88899">
        <property type="protein sequence ID" value="BAV88899"/>
        <property type="gene ID" value="RA11412_2600"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2600"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
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    <dbReference type="Pfam" id="PF00994">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="15"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="172" mass="18770" checksum="77E3E0604A8C281F" modified="2018-10-10" version="1">MSAEEIQLPENLTGLVIVASTRAARGIYEDKSGPIAVEWLRSRGFDTPDAVVIEDRQIIDYFNTLIADGKKNNNLPTFILTSGGTGLNTDDQTVEAVRPHLDKEIPGIMHAFWANGLQNVSSAVLSRGVAGVIDKTFVMTLPGSRGGVKDGVKTLDPLVEHICRQMEDYHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R514</accession>
    <name>A0A2Z5R514_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ECF transporter S component</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Substrate-specific component YkoE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08415</name>
        <name evidence="2" type="ORF">RA11412_2740</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89039">
        <property type="protein sequence ID" value="BAV89039"/>
        <property type="gene ID" value="RA11412_2740"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2740"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017195">
        <property type="entry name" value="ABC_thiamin-permease_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09819">
        <property type="entry name" value="ABC_cobalt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037394">
        <property type="entry name" value="ABC_thiamine-permease_YkoE_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="199" mass="20685" checksum="68466AE077B58B16" modified="2018-10-10" version="1">MSHKSRLTWRVNEIVIVSVVAVACAVVFWVWDIGVSPAAKTIFAAVPEYQPLIGGAWLLAGVLGGYLIRKPGAALYCEVVAAIISVLLTGGAFSGEILLAGLIQGVGAEIAFAVFAYRRWNLPVAVFAGALAGLFMGGNEILIYYPDMDPIKAAIYIVCSVLSGLVMSGIGSWALTKALAKTGVLASLASGAQARTVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QV82</accession>
    <name>A0A2Z5QV82_9MICC</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0008</name>
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    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86307">
        <property type="protein sequence ID" value="BAV86307"/>
        <property type="gene ID" value="RA11412_0008"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0008"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="56" mass="5652" checksum="8EE44E10090E35D1" modified="2018-10-10" version="1">MMNKLGVTDIDVAVIVLASGSGTRLGEPVPKAAVKVGGKTLLHHALQGFTTPGSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QV86</accession>
    <name>A0A2Z5QV86_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose 1,4-beta-cellobiosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08145</name>
        <name evidence="4" type="ORF">NCTC10207_01979</name>
        <name evidence="2" type="ORF">RA11412_0001</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_JQHE01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86300">
        <property type="protein sequence ID" value="BAV86300"/>
        <property type="gene ID" value="RA11412_0001"/>
    </dbReference>
    <dbReference type="GeneID" id="32323313"/>
    <dbReference type="KEGG" id="raj:RA11412_0001"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI24233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="132" mass="14233" checksum="244CF5E0A5263775" modified="2018-10-10" version="1">MGEAIVNDDGSWSKNYKTAQLIVKKDGSWEEKNDLRELTVNADGSYTYAATNGYRTYEVKADGSWTLKYQDGTVYSVSADGKMTKEGGDGKSLASPFEQATKQQGVGARQASEPKAVKAAAPVEPVTAKNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVG4</accession>
    <name>A0A2Z5QVG4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3073 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Protein of uncharacterized function (DUF3073)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07830</name>
        <name evidence="4" type="ORF">NCTC10207_02048</name>
        <name evidence="2" type="ORF">RA11412_0084</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887634.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86383">
        <property type="protein sequence ID" value="BAV86383"/>
        <property type="gene ID" value="RA11412_0084"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0084"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021426">
        <property type="entry name" value="DUF3073"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11273">
        <property type="entry name" value="DUF3073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI24368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="69" mass="8029" checksum="A6E7100C5049A9B9" modified="2018-10-10" version="1">MGRGRQKAKATRQAREMKYFSPETDYSALERELSSAKKSKTSDSSQHRYDDEDDYSAYAEKYANYDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVG5</accession>
    <name>A0A2Z5QVG5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86387">
        <property type="protein sequence ID" value="BAV86387"/>
        <property type="gene ID" value="RA11412_0088"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0088"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="172" mass="17614" checksum="B8A0D844E6A94233" modified="2018-10-10" version="1">MGGARDTTEVIDAAIHISGGQVTVNVEGDGIDSNGSQTYTGGTVTINGPSTYLNNSVDANGELLLNGVNIAAAGSGAEMFKVPSEKSTNGYLRVVNLDVFTPGRTVQVTDTETGAVVANYTVVTSGVQLFFLSNPSLVKGNNYTVYTVSEPVQEGSTTLAPGAVEVGTYAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVJ8</accession>
    <name>A0A2Z5QVJ8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent protein deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_07785</name>
        <name evidence="4" type="ORF">RA11412_0097</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="BAV86396"/>
        <property type="gene ID" value="RA11412_0097"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0097"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="317" mass="34663" checksum="A99583563DC6BAD6" modified="2018-10-10" version="1">MDKWTDTTGFDNHEIAAVHRAAIRSIQRVVAETAQPHQPEVALEGVAGMLRAGRVLALTGAGVSTESGIPDYRGPAGSLREHRPMTYQEFRYDDAARQRYWARSYVGWRRMKEAKPNRAHYALVELEQHGAVSGVITQNVDGLHAQAGSRNILALHGDLSTIICLTCGHREGRASLDIRLDAANPGYLARLAGTDLRVNPDGDVELDNDFIRDFVMIGCIACGSQRLKPDVVYFGESVPAERKERLRHMLADSTALLVVGSSVAVMSSYKIVLDTLKANKPVAVLNGGPGRADARATYLWRTNVGDALGQLLDRLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVU4</accession>
    <name>A0A2Z5QVU4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86414">
        <property type="protein sequence ID" value="BAV86414"/>
        <property type="gene ID" value="RA11412_0115"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0115"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="74" mass="7746" checksum="ACCA111A37CE7D66" modified="2018-10-10" version="1">MPLPGSISGFKRGSVRGAALGCATRCCAVLGGVAGCGTVRSRRLLRTGLIHRSRRTAGSTTTGFRPVRWGRCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW12</accession>
    <name>A0A2Z5QW12_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF2029 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Probable conserved integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_06875</name>
        <name evidence="8" type="ORF">RA11412_0298</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86597">
        <property type="protein sequence ID" value="BAV86597"/>
        <property type="gene ID" value="RA11412_0298"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0298"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="426" mass="46332" checksum="1E3837EC1BB64486" modified="2018-10-10" version="1">MKKHPAAFIPHALFVLAVIYMVQYVINDGGNDLYIYRLGAETIADGPGGPGLYEVSLDNYPFTYPPFAALLFIPFALMPKEVGMALMMLITAGIAWWLGWVITRYVSRRGVRIPLYEHLGTAGCASTLAMLIWASGPWRLTTHFGQINAVILLLVLADFLRPAKRIPRGALIGIAGGIKLTPLAFGLILLLRKDWRGVASVAGGFVGTIALGFLAVPGEAAYYWGVAVRNTSRIGVTAFYDNVSLTGIFAHQGVPEPIATVLVVALSLFLLVATAALMCLFIRANMVFSQVALNAFLMLQISPISWSHHNTWYPVLLVALCLEIFPLIMPAARPVVYVLSAFASVIALVGMYISPFWLAVLFSPKYSSHEMIYLPQGGAGLVASSAPYAAMYLVVVLVFLTYWAHRAAIDARVDSGRFRAPERPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWD1</accession>
    <name>A0A2Z5QWD1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylate cyclase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">DUF3662 and FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_06385</name>
        <name evidence="4" type="ORF">RA11412_0426</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86725">
        <property type="protein sequence ID" value="BAV86725"/>
        <property type="gene ID" value="RA11412_0426"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0426"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022128">
        <property type="entry name" value="FhaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042287">
        <property type="entry name" value="FhaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12401">
        <property type="entry name" value="DUF3662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="209"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="288" mass="31120" checksum="AD1F4D8C28C62F5F" modified="2018-10-10" version="1">MKFMDRLERLEQGIGQAVGFSKGFGTFEKADIANRIRTVMDDESYIDPNEMLMAPNIYAVNFSPADFDRIREWGNPFAIELCDLAISHARAQGYSLIGAVRITFHSLPEVHPGDFQVVPTFEYFSTPPAQGALPVQTPVNDAPPSPHGAPSYSPVRPPRARSLPTRITKPQAAPAQQPPQAAPPAPAPQPLVPHLEIDGQPIELTSFPVVIGRGSVADIRVDGKSISRRHLQISHQSGAYIVTDLGSTNGTMLNGTALRTPATLHDGSLLRLGDTSIFFRMMPAGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWI9</accession>
    <name>A0A2Z5QWI9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86778">
        <property type="protein sequence ID" value="BAV86778"/>
        <property type="gene ID" value="RA11412_0479"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0479"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="39" mass="4625" checksum="BDDAD2EBE9856D90" modified="2018-10-10" version="1">MYTKAVEKIHNPCGLLKSHILWMPSIHCIHRARIMHTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWM2</accession>
    <name>A0A2Z5QWM2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86827">
        <property type="protein sequence ID" value="BAV86827"/>
        <property type="gene ID" value="RA11412_0528"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0528"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="58" mass="6248" checksum="616E33FE0FEF5FF4" modified="2018-10-10" version="1">MDEYKAGRPRPSASGGTTPAGAKINGDGSWEYKDANVSMHVHPDGTWEWSNSGGIRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWT0</accession>
    <name>A0A2Z5QWT0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86841">
        <property type="protein sequence ID" value="BAV86841"/>
        <property type="gene ID" value="RA11412_0542"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0542"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="61" mass="6874" checksum="DF9E8BBBAE013326" modified="2018-10-10" version="1">MKNIQLNPDGSWDMTVKENVGYGTRQVIHVNPDGTFRYMKDKEVKTVTCADGSWVEITPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWV0</accession>
    <name>A0A2Z5QWV0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinolone resistance protein norA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86861">
        <property type="protein sequence ID" value="BAV86861"/>
        <property type="gene ID" value="RA11412_0562"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0562"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="173" mass="17880" checksum="907B46DCABCDC1CC" modified="2018-10-10" version="1">MYTLNQPLFAAQDVPIATWGVIAGVGQLLAAGYNYAAGRIEKRVGRKTALLLAMGYGAAGFCLMAVPHVLAVVSGFLLVVVGIHARGPITSAVTNKLIPAHRRATVLNVASSVGSLVGIVVNPLVGLGAETSTRLTVLAIGGVLLALTLTWIPIANRYLGADEDADMTEAHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWW3</accession>
    <name>A0A2Z5QWW3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoU rRNA methylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86927">
        <property type="protein sequence ID" value="BAV86927"/>
        <property type="gene ID" value="RA11412_0628"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0628"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="133" mass="14847" checksum="65D5DEBE59662850" modified="2018-10-10" version="1">MVRTANAFLAKEVHIIGKKRWNRRGAMVTDRYQHVRHHPTIEDFVAWAQGEGLDIIGIDIFPDSVPLETYDLPKNCVLVFGQEGPGLSEEIHAAARDTLSIEQFGSTRSMNAATAAGIAMHAWVRRHVFGQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWZ8</accession>
    <name>A0A2Z5QWZ8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Repressor CsoR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_0666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86965">
        <property type="protein sequence ID" value="BAV86965"/>
        <property type="gene ID" value="RA11412_0666"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0666"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV86965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="107" mass="11868" checksum="4F5319338FF0A6ED" modified="2018-10-10" version="1">MTKHDSSAQPHGYTPNKEAHLKRLRRIEGQVRGIARMVEEDKYCIDVLTQVAAVSKALHAVSLNLLEEHMGHCVTNAAIESERTGDATIVDEKIKEATAAISRMMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX04</accession>
    <name>A0A2Z5QX04_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nitrate reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Pyrimidine permease RutG</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Uracil-xanthine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rutG</name>
        <name evidence="9" type="ORF">I6I94_05635</name>
        <name evidence="10" type="ORF">NCTC10207_00104</name>
        <name evidence="8" type="ORF">RA11412_0612</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86911">
        <property type="protein sequence ID" value="BAV86911"/>
        <property type="gene ID" value="RA11412_0612"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0612"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VEI22038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="444" mass="46190" checksum="09415794D3D9D292" modified="2018-10-10" version="1">MSTQKSGFGWRLHGDGRSIKPGSVVAPSERLAWPITIGIGAQHVVAMFGATFLVPLLTGFPPATTLFFSGLGTVLFLLITRGRVPSYLGSSFAFIAPLAAATNQHGPAGALGGIVMAGLSLFLVGVIVQFAGTGWLTKLMPPVVTGAIVALIGFNLAPSAKANFMKAPITALVTLISIILISVLFKGIIGRLSILLGVIIGYVTAVVRGEVDFSTIEQTVQQQGIIGLPHFQNPEFHWELAGLFIPVILVLVAENIGHVKSVALMTGENLDNYSGRALMADGLATTVAGFGGGSGTTTYAENIGVMAATKVYSTAAYWVAAIFAIALSLFPAFGAAIATVPAGVLGGAATVLYGMIGMLGVRIWSENRVDFSNQINLTTAAVALIVGIADYTWEFSGLSFAGIALGTAATLIVFHLMTFIAKRTKAAGDPLDPFTDKDHDELGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX05</accession>
    <name>A0A2Z5QX05_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86920">
        <property type="protein sequence ID" value="BAV86920"/>
        <property type="gene ID" value="RA11412_0621"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0621"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="213" mass="23966" checksum="59636EB770E087DC" modified="2018-10-10" version="1">MNFVFDIDGTTSFNGMVIEPAIEREIYALLQAGHRVVFASARPVRDILPMLSEDVRTHSGLALIGANGSLLYRDGQLRAREHLDTHSYAKIRDLIKRHGLHYIVDSLDSYAFDLPDAHVLVERLNPEGTDRLVSLKDLDNPVKIILLDINNPHLYTELEETIASLNLHVTKHQDATTSIDLAPGECIKFRLSRRRLARTRAKNPTPISRSATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX26</accession>
    <name>A0A2Z5QX26_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86940">
        <property type="protein sequence ID" value="BAV86940"/>
        <property type="gene ID" value="RA11412_0641"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0641"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="38" mass="4254" checksum="A346E5B134CDA3C9" modified="2018-10-10" version="1">MQMRGAAYTLGGTPHPLYPQKATANNYFFAVSRETFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX61</accession>
    <name>A0A2Z5QX61_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3180 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_05190</name>
        <name evidence="3" type="ORF">RA11412_0713</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87012">
        <property type="protein sequence ID" value="BAV87012"/>
        <property type="gene ID" value="RA11412_0713"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0713"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021517">
        <property type="entry name" value="DUF3180"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11377">
        <property type="entry name" value="DUF3180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="177" mass="18214" checksum="A543033BCB07D41F" modified="2018-10-10" version="1">MKPIPLRIILLCAALGVIAAVAVNSMLVSSGGGEIVMSPVVIVVCLCMGGGALWLGFQVARWRNIETRAKAKNMNPVAAARVLAYAQGSILTGASLTGWMLGLLIYQLSLVSARGVTGVLWVTGANLVGAAALLAMGIWAQYLCRIPPDDPDGNSSSGGSNSGKLAADGYSRVSDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXA0</accession>
    <name>A0A2Z5QXA0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87052">
        <property type="protein sequence ID" value="BAV87052"/>
        <property type="gene ID" value="RA11412_0753"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0753"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="55" mass="6238" checksum="7460BE145F0A76CF" modified="2018-10-10" version="1">MIRTASDTANQLTPSGKDWWCWKQNPAPAPAHQQDAALRPADSTGHQYHYNRSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXA7</accession>
    <name>A0A2Z5QXA7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_05375</name>
        <name evidence="1" type="ORF">RA11412_0674</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86973">
        <property type="protein sequence ID" value="BAV86973"/>
        <property type="gene ID" value="RA11412_0674"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0674"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT90018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="42" mass="4582" checksum="E7D0F543382FFFB1" modified="2018-10-10" version="1">MMFFELMETAQAILVSLILTDGSAQAVSNALDTLKVVVRNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXC6</accession>
    <name>A0A2Z5QXC6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87082">
        <property type="protein sequence ID" value="BAV87082"/>
        <property type="gene ID" value="RA11412_0783"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0783"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="202" mass="21808" checksum="409B662D4944797A" modified="2018-10-10" version="1">MGGPARRRRGHVHPRRQRRQRPLRGAGLWFAAPHTASGEYTGTTTLRTGARFSIKYTFTFADEIQTRPPLLWEDGEQQQVAALAQSAGGARSNNPRLAAFNGAGFTAVFRESDSYGTEWRGTLDIVTAEDAVASAEGMQVFNQVLLSQVPVYYDQVGESFSLRTTVTVVDATLLLEPVNSAAPSEQNIAGLSASATITHSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXM6</accession>
    <name>A0A2Z5QXM6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RA11412_0893</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87192">
        <property type="protein sequence ID" value="BAV87192"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PCN-bd_Tpept"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        <location>
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            <end position="655"/>
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        <source>
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        </source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAV87192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="725" mass="78596" checksum="0BFAC1332B03504E" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXT4</accession>
    <name>A0A2Z5QXT4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87153">
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        <property type="gene ID" value="RA11412_0854"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="39" mass="4198" checksum="87D44D18BD099CB4" modified="2018-10-10" version="1">MDCALVHVSPLMTRVAGAKTRPVNPYPYSIGDMLLLVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXT8</accession>
    <name>A0A2Z5QXT8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="30"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="194" mass="22310" checksum="31D12E702019913F" modified="2018-10-10" version="1">MNSAYAGGYKYDYTGKPSLNTDYITEYKAETKNGVQTVTFKINPKAKFNDGTPIDIESVRAAHRIFTAPAGEYQVTDAPMWKQVKSVEENGDKFSVKVTMEKPYYPIDGGFVISTFIHPALVDKKLFNDGLVDKPLDKYWAGPFKVENWDVSQNSLILTRNDKWWGRSLCWRKSLFVLWVRQPLWQHSRTAKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXU3</accession>
    <name>A0A2Z5QXU3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent DNA helicase RecQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_0755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87054">
        <property type="protein sequence ID" value="BAV87054"/>
        <property type="gene ID" value="RA11412_0755"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0755"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
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    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="114"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="460" mass="49430" checksum="BB6E799A19748975" modified="2018-10-10" version="1">MAAATRPRLGLLVVDEAHCISDWGHDFRPDYRRIGRLIDDLPPRIPVLATTATANERVGADIAEQLAAHPPTGRTPDPDSSEPQKVLTLRGPLTRDSLRLGVLHLKEPAERIGWLIAHLNTLPGSGIIYTLTVSAAQDTARALAHAGYRVLPYTGGMDAEERITAEEALKNNQVKALVATSALGMGFDKPDLGFVVHLGAPSSAVSYYQQVGRAGRGAINADVLLLPGPEDTAIWEYFATASMPDEANAHAVLTALAEEPEGLSIPALESRVQLRRTTLELLLKVLSVEGAVHKNKSRWASTGTSWAYDAARYEAVARARVAEQKAMLAYENTTTCRMVFLARELDDNTAEPCGTCDTCTEPWYPRTVPQEALTAATGSLTAAGVEITPRKQWASGLSKLVGDTAPAGTRIPADEQANTGYALARLSDLGYGAQLRELFTTDAQGTPHDAPHPRPSVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXW8</accession>
    <name>A0A2Z5QXW8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_04010</name>
        <name evidence="3" type="ORF">RA11412_1008</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87307">
        <property type="protein sequence ID" value="BAV87307"/>
        <property type="gene ID" value="RA11412_1008"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1008"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Severitt S."/>
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                <person name="Sadzewicz L."/>
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                <person name="Boylan J."/>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="QQT89903.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="63" mass="7132" checksum="CAFD6D1C975B40F3" modified="2018-10-10" version="1">MDNVLLWNRLNIKPMLLRRKAKGALPWKPTKPRERQVSNALKVYGMLAASADKGGVRILPEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY47</accession>
    <name>A0A2Z5QY47_9MICC</name>
    <protein>
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        <alternativeName>
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        <alternativeName>
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    <gene>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037232654.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87362">
        <property type="protein sequence ID" value="BAV87362"/>
        <property type="gene ID" value="RA11412_1063"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1063"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="4">
        <location>
            <begin position="15"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="5">
        <location>
            <begin position="409"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="2">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="324"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI22438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="468" mass="49795" checksum="3D9CDAB7E4FB0111" modified="2018-10-10" version="1">MAENIEYRIEHDTMGEVRVPANALYRAQTQRAVDNFPISGQTLESAHIRALALVKKAAATANEELQVLDAERAQAIREAADLVATGEYDEHFPIDVFQTGSGTSSNMNTNEVLATLATRSLESQGIEVHPNDHVNASQSSNDVFPTSVHVAVTEALVKELIPSLEVLAASLEKKSAEFKDVVKSGRTHLMDATPITLGQEFSGYAATVRYGIERVNASLPRVAEVPLGGTAVGTGINTPAGFSARVIELLAEETGLPLTEARNHFEAQANRDGLVEVSGQLRTLAYGLMKISNDIRWMGSGPNTGLGELHIPDLQPGSSIMPGKVNPVICEAAIMVAAQVIGNDATIALSSTNGAFELNVGIPVMAANLLQSIRLLANVSRVAAEKMIDGLSANVERCRFLAEASPSTVTPLNKLIGYEAAAKIAKYSVANKVTVRDAVVALGYVERGEVTEAQLDEALDVTKMLGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY56</accession>
    <name>A0A2Z5QY56_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87164">
        <property type="protein sequence ID" value="BAV87164"/>
        <property type="gene ID" value="RA11412_0865"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0865"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="88"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="308" mass="35015" checksum="FBB4272A81C0F133" modified="2018-10-10" version="1">MMTSTAIPLGMPKVVHYGEGNIFENEPFPEYAKRELKNDQLRNNLRFVTHAIRNKRARVTSELPDWQELRTTGEMVKNYVLFNLPQMLEQFERNFTARGGHVHWARDAHEANQIALELIREQGVDEIIKIKSMATAETGLNEFLEENGINAIETDLAEEIVQLGEDRPSHILVPAIHRNRREIRDIFLKKIEGINPDITDEPAELAEASRNRLREKFLSTKVAVSGVNFGIADTGTMTIVESEGNGRMCLTLPDTLISFMGIEKLLPTFQDYEAFLQLLPRSSTGERMNPYTSMWTGVTPVTARRTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYG5</accession>
    <name>A0A2Z5QYG5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87508">
        <property type="protein sequence ID" value="BAV87508"/>
        <property type="gene ID" value="RA11412_1209"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1209"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="46" mass="5231" checksum="6947A93B7438113B" modified="2018-10-10" version="1">MTPFLIPTRLARMPLGLVLVAMPTSQDFDAWSLLHSVKYYSISIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYP9</accession>
    <name>A0A2Z5QYP9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87411">
        <property type="protein sequence ID" value="BAV87411"/>
        <property type="gene ID" value="RA11412_1112"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1112"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="150" mass="17108" checksum="557902CC82E327C6" modified="2018-10-10" version="1">MAYHFGYPAVQNYPRIAPAPYSIPLGELGVQLFFIISGYVILLSAIKSGSALKFGISRFARLYPTYWLALAVAAAVYFFYGNPSRNITVIQTLINATMIQRFMLVDNVDQVYWTLAIELQFYLLMGFYLALRRGRIYRREITIGIFVGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYX8</accession>
    <name>A0A2Z5QYX8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cell division protein FtsK</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">DNA translocase FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I6I94_03020</name>
        <name evidence="14" type="ORF">RA11412_1264</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homohexamer. Forms a ring that surrounds DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87563">
        <property type="protein sequence ID" value="BAV87563"/>
        <property type="gene ID" value="RA11412_1264"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1264"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="14" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="13">
        <location>
            <begin position="629"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="330"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="420"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="976"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="465"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="646"/>
            <end position="653"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV87563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QQT89600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="1024" mass="110298" checksum="0B601489E485901A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYZ5</accession>
    <name>A0A2Z5QYZ5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87583">
        <property type="protein sequence ID" value="BAV87583"/>
        <property type="gene ID" value="RA11412_1284"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1284"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4336" checksum="B03477821B564F7F" modified="2018-10-10" version="1">MVPILPGGCGAVAVFRYLMPAAQSVRWNRWLVGAGCCGAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ30</accession>
    <name>A0A2Z5QZ30_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA binding methyltransferase FtsJ like</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TlyA family RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_02755</name>
        <name evidence="3" type="ORF">RA11412_1327</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87626">
        <property type="protein sequence ID" value="BAV87626"/>
        <property type="gene ID" value="RA11412_1327"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1327"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="245" mass="25928" checksum="3DE75BCEA710B5CB" modified="2018-10-10" version="1">MRLDKYLAHNGLATSRTLAAKLIAAGAVSLNGKPVRKASLDVTPGDNVQVHRSELTEYVSRAGHKLAGALNAFPQVQVSGKRCLDAGASTGGFTDVLLRAGAAHVAAVDVGHNQLVQQLRDDARVSVYEGLNVRYLKPADIGGQVDVTVGDLSFISLTLVMRPLAEATVPGGDLLLMVKPQFEVGKHRIGKGGVVVDAQARAEAVQVVQNSARECGLTVRATSPSPLPGQDGNKEYFLWCTKPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ53</accession>
    <name>A0A2Z5QZ53_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_02675</name>
        <name evidence="2" type="ORF">RA11412_1347</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87646">
        <property type="protein sequence ID" value="BAV87646"/>
        <property type="gene ID" value="RA11412_1347"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1347"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT90063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="212" mass="22710" checksum="EB2D0358457D9484" modified="2018-10-10" version="1">MNILLLGASGPTGQQVLQQALEHGDTVTALARHPETLEQFGQQVKVVRGDATSAEDLTKAMDGQDVIISALGRGKALRAENLFTDAILAILQAASATGVHRLVWLSSFGVAHTYDSATFSQKAVYKTILRNIYANKAEAEKLLRASDLDYTIVYPTALTNGPATDTYRVGENISMNSAVLKVSRADVGHFMYRAALDAEWIGRDAVITSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ90</accession>
    <name>A0A2Z5QZ90_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3040 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Probable conserved transmembrane protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Protein of uncharacterized function (DUF3040)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_02520</name>
        <name evidence="5" type="ORF">NCTC10207_00784</name>
        <name evidence="3" type="ORF">RA11412_1387</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023134584.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87686">
        <property type="protein sequence ID" value="BAV87686"/>
        <property type="gene ID" value="RA11412_1387"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1387"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021401">
        <property type="entry name" value="DUF3040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11239">
        <property type="entry name" value="DUF3040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI22699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="132" mass="14248" checksum="C35C1133FFADDF59" modified="2018-10-10" version="1">MALSEREQKVLDQLEELMHAEDPQFASSMSSTGNTAPVFSARHMVLGILCVLAGLGIIIGAVASKIILLGIVGFIVAAGGVYFATTSKKTPIDSFLGGKAKGASAEKAQQQRKQSKLMERLEERWDEREQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ98</accession>
    <name>A0A2Z5QZ98_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87767">
        <property type="protein sequence ID" value="BAV87767"/>
        <property type="gene ID" value="RA11412_1468"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1468"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="50" mass="5474" checksum="EEC0C2134098E898" modified="2018-10-10" version="1">MGVVLLTVPIPENIKHGWTLAGAIIGAVLWLSIEAITINNIRILYFDSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZC9</accession>
    <name>A0A2Z5QZC9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal large subunit pseudouridine synthase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87713">
        <property type="protein sequence ID" value="BAV87713"/>
        <property type="gene ID" value="RA11412_1414"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1414"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="75" mass="8273" checksum="4AB5522CB6D2B79C" modified="2018-10-10" version="1">MSGTGHMRENEEGIHAEFEVSEPIAGMRLDAALAGVFDVPRTRASAWIRDGHVRLTRAHQPVKIGKSHKLSVGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZD3</accession>
    <name>A0A2Z5QZD3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_01845</name>
        <name evidence="3" type="ORF">RA11412_1556</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
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                <person name="Bowen H."/>
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                <person name="Myers T."/>
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            <strain evidence="4 6">FDAARGOS_1137</strain>
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    </dbReference>
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    </dbReference>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="110"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAV87855.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
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            <dbReference type="EMBL" id="QQT89397.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="110" mass="11986" checksum="022A157B848F4C2E" modified="2018-10-10" version="1">MTRKDVALALTISVAALLLYVGVKQVLGGHWDWVTFVIWVLGALLFGFGMVYAKSFLMRLVDEMNEDGVAPETQRKRQPSTGAESSTNSDSEPETGKTANEHPSTDRNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
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    <name>A0A2Z5QZE5_9MICC</name>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
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            <dbReference type="EMBL" id="VEI22620.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <sequence length="194" mass="20734" checksum="C3068462088D6BB9" modified="2018-10-10" version="1">MLPPNTREPLAAFVRNTLIPLSTSSAPHHLPSQRGAVETYISFINPVNYEILRGMTNETQKFTFEAEHGKPVHGHTDLDAEQLEALNAQMRDIADVPAIEIIGAAAVHLMSAAAIKCGLGAEQNAEDLKDLDEARKLITALAGFITAAAPEIGSQHAAPLRDGLRTLQLAFREASPIPDEPGQGPGEKFTGPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZI1</accession>
    <name>A0A2Z5QZI1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="8" type="ORF">RA11412_1467</name>
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    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
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    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nambu T."/>
            </authorList>
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    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT89463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87766">
        <property type="protein sequence ID" value="BAV87766"/>
        <property type="gene ID" value="RA11412_1467"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="336"/>
            <end position="374"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87766.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QQT89463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="374" mass="38779" checksum="9C059828BF3CE058" modified="2018-10-10" version="1">MLPIITVALTATILGGVLPFLVRPLLHTLNMVDLPNERSSHTTPTYRGMGLATALAVCASFGVATAAGWTVNTGISVTLLAGMAAALLLGWIEDVSGIGIAIRAGVQLLIGAGVAGVLSVLMNVPIFWAVPAAIFVAAYINVANFMDGINGISGCHGLAAGLCYSFTGYLTELPWLTLGGLAIAGAFAAFLPWNVRSGRNVFLGDAGSYLLGAGLSILAVGTWFANVNPLVALAPLLVYLADSGTTLLRRMAAGEQWYKPHRTHVYQRLTDVGFTHLGSAMVVTGLTVLVWALILNGLNFWSSDLPILGVALLAFAVLVVLLYLSLPTLIARQKTAAPSENNTAAPEDGTGGSLGSSQASFRGGQNPHDSGEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZI6</accession>
    <name>A0A2Z5QZI6_9MICC</name>
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        <submittedName>
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    </protein>
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        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="165" mass="17773" checksum="6F333DF74F8A56E6" modified="2018-10-10" version="1">MKKNSRISQGSSPRMRGTRGYQDGARTEAGLIPTYAGNTHNVDNVLSVLWAHPHVCGEHLPSPSASLDDWGSSPRMRGTRCTTFWDLAGVGLIPTYAGNTHCGIGAESVMWAHPHVCGEHSSILRSTGPSVGSSPRMRGTRPHGRRHTVPDGLIPTYAGNTPRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZI7</accession>
    <name>A0A2Z5QZI7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C4-dicarboxylate-transport transmembrane protein DctA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Cation:dicarboxylase symporter family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_02725</name>
        <name evidence="7" type="ORF">RA11412_1335</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87634">
        <property type="protein sequence ID" value="BAV87634"/>
        <property type="gene ID" value="RA11412_1335"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1335"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="486" mass="50857" checksum="0695BEA0FBADB3A2" modified="2018-10-10" version="1">MSTASAHNSSPKKTVEKKPFYKDPTHMLYLSVIAAVIIGCVLGLTAPGFAKGLAPIGTGFIALIKMMIAPVIFCTIVLGVGSIAKAATVGKVGGMALLYFVLMSTFALGIGLVVGNIIEPGSALHYDPATTKYTLPNNSSGSHGGGDTVSFLLGIIPTSLLSALTNDNILQTLFVALLMGFALQKMGPVGQPILKFLTYCQALVFRLLMMIMWLAPLGALGAIAAVVGSTGLQAISSMFVLMAAFYITCILFVVVVLGSILKLFAGVNIFSLLKYLAREYLLIFSTSSSEAALPRLIAKMEHLGVSKPVVGVVVPTGYSFNLDGTAIYLTMSALFVAEAMGTPLALGEQLSLLVFMIIASKGAAGVSGAGIATLAGGLQSHRPDLVNGVGLIVGIDRFMSEARAVTNFTGNAVATVLMGKAVKEIDMDRVRSVLKGELPFDENTMGDALHGDQYVDDAVAQKSPTKQIPVVPPENIKPRTHIDSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZM6</accession>
    <name>A0A2Z5QZM6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_01715</name>
        <name evidence="6" type="ORF">RA11412_1609</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87908">
        <property type="protein sequence ID" value="BAV87908"/>
        <property type="gene ID" value="RA11412_1609"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1609"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="203" mass="22021" checksum="56D24D7B93BE9392" modified="2018-10-10" version="1">MSDIVTIRGFAATRPELRALPSGVPVASFRVASTPRWFDAASGTWQQGRTNWYTVTAFRRLAKNIAASIDKGHPVLLTGRLQIKQFTHKDGSSGSSAEIDAQSIGVDLGYGTCIFERGVERRDLAPQNQNEQHPEHAEPITRNSIVRMHPETAPETEGDGPVRNNAAYDNNGVHCDNDGTFEHADTRTRPAAAGTDSKVQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZN6</accession>
    <name>A0A2Z5QZN6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">panB</name>
        <name evidence="11" type="ORF">I6I94_02390</name>
        <name evidence="10" type="ORF">RA11412_1421</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87720">
        <property type="protein sequence ID" value="BAV87720"/>
        <property type="gene ID" value="RA11412_1421"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1421"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="298" mass="31663" checksum="C9188B07995127C9" modified="2018-10-10" version="1">MSENENAPYATSTVTNTAETPGMAQTPFSLDTVKKIRTIHLERAKAEGEKFSMLTCYDFSTAQVFDRAGIEMLLIGDSAANVMLGYDSTLAITLDEIIPMVAAVSRGAKRAMVVADLPFGTYEQSPQQAVASAARLMKEGGAHAVKIEADARMADWVQALVTAGIPVVAHVGFTPQAEHALGGFRVQGRHGTADRVVEDARALAAAGAFCILMEMVTAETAERVNQAVGAVPTIGIGAGNTADGQVLVWQDAMGVRQGRMPTFVKQFAQVGQLLEDAARAYRSEVRAGSFPADEHTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZP4</accession>
    <name>A0A2Z5QZP4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87942">
        <property type="protein sequence ID" value="BAV87942"/>
        <property type="gene ID" value="RA11412_1643"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1643"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="78" mass="9326" checksum="7E8E2D52CCF522CC" modified="2018-10-10" version="1">MPETDWRDAQYDMLHLPVTETVRYRYEFNGNRAATILSDGEVQNYFYNLHDQLVKLEIFKKTARKKRRLTATMPWADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZP9</accession>
    <name>A0A2Z5QZP9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87843">
        <property type="protein sequence ID" value="BAV87843"/>
        <property type="gene ID" value="RA11412_1544"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1544"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="107" mass="11875" checksum="2FC72256B1C0AE66" modified="2018-10-10" version="1">MIAPSATRRLLKHMIPVLDTSRENAAAEAPPQEQPVLQHQELIEQLTPREYEVLKLVAEGLSNSEIGRELVLSEATIKTHVSHVLNKLDARDRVQAVIMAYEAGIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZR4</accession>
    <name>A0A2Z5QZR4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">trpB</name>
        <name evidence="14" type="ORF">I6I94_01595</name>
        <name evidence="13" type="ORF">RA11412_1638</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87937">
        <property type="protein sequence ID" value="BAV87937"/>
        <property type="gene ID" value="RA11412_1638"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1638"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="68"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV87937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT89356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="446" mass="48211" checksum="C1D43BB9D161FC4F" modified="2018-10-10" version="1">MSENLAETFLKSRTLKDAPGPYFGQYGGRWMPESLIAAMDELEQTFNEAKNDPEFIAQFQRLSREYSNRPSLLTEVPRFSEHAGARVFLKREDLNHTGSHKINNVIGQALLAQRMGKTRLIAETGAGQHGVATATAAALFGMECVVYMGEEDTERQALNVARMQLLGAKVIAVQNGSRTLKDAINEALRDWVANVENTHYLLGTAAGAHPFPAMVRFFHDAIGSETREQIQSLTGRLPDGVAACVGGGSNAIGIFHAFLDDRDVEIYGFEAGGDGVETGRHAATITLGRPGMLHGAVTYLMQDEDGQTIESHSISAGLDYPGVGPEHSYLSDIGRVSYQPVTDTEAMEAFRLLCRTEGIIPAIESAHALAGALRVCQQWAAQDPAAAREKIMVVCLSGRGDKDMETALKWFDLGKAIPSSTLMTGNKEAAAQGAAENLKQAESEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZT3</accession>
    <name>A0A2Z5QZT3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ComA operon protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87957">
        <property type="protein sequence ID" value="BAV87957"/>
        <property type="gene ID" value="RA11412_1658"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1658"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="63" mass="6610" checksum="207590B906D1D3A9" modified="2018-10-10" version="1">MAVGVDVNATHLRPATAGYVTAVCTAVKLGRTVCVHTIEITDEAGRGVCSARITNMLIPRTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZV8</accession>
    <name>A0A2Z5QZV8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87744">
        <property type="protein sequence ID" value="BAV87744"/>
        <property type="gene ID" value="RA11412_1445"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1445"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="270" mass="29235" checksum="F66A25BC4D738A3C" modified="2018-10-10" version="1">MTALIVKEFRELARDRRTLAMLVILPVILLIIFGYAANLSVDKVSVAVIGSQAESFAHKLDTYSAARDKLDITQIEHTRGGEDAEQLLRDRKADVVVVADRPDTSDKPISEQMRVYTDGSNLFVAQTAQGAFVQISAEDAQNRITEAKSAYRNAAAQAQKAQRDHTASPAQGPSAAPAGPGAAPSDFTSMESPKLDPDDLVTVLFNPELKTSWVMVPGLIGLILLFIGTVITSIGLVRERETGTLEQLAVMPLRPSSIILGKIVPYLWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R022</accession>
    <name>A0A2Z5R022_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87891">
        <property type="protein sequence ID" value="BAV87891"/>
        <property type="gene ID" value="RA11412_1592"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1592"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="679" mass="72861" checksum="75DD7E4E66EB713A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R031</accession>
    <name>A0A2Z5R031_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87824">
        <property type="protein sequence ID" value="BAV87824"/>
        <property type="gene ID" value="RA11412_1525"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1525"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="220" mass="23450" checksum="D39D50D3AC3C4EC4" modified="2018-10-10" version="1">MNPYYRRDTGTAQSLLAAANYKNEAIECYYPVDVSLPWMSTPQVIYSQLIGSLIEVGLNIKPVPLGWAEYCEKARSNGAERGMVLGGFYGAYRDPYAFLGPVLAPLLVAQWLNEKDPNRAKSLPQTAQNPVSSATASASPQPSASASASASPSASESESASPSASPAEGEQGQPSPTPSPTPTVKPAHIDPAPRLSRLCAIFEMPILRRTWKISALSIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R047</accession>
    <name>A0A2Z5R047_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-Acetyl-D-glucosamine ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87890">
        <property type="protein sequence ID" value="BAV87890"/>
        <property type="gene ID" value="RA11412_1591"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1591"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="192" mass="20473" checksum="2408B8BAB29B01C0" modified="2018-10-10" version="1">MGTTRRPPHGLEIAGLIPTYAGNTSVRSEWSVGIIPHPHVCGEHLIATFAVFACQGSSPRMRGTLSPPRCRFPTKGFIPTYAGNTPTGPCGLRCSGAHPHVCGEHMVNNIVGSKGSGSSPRMRGTHGKPVPLSGRVGLIPTYAGNTIRRLRFSPSRRAHPHVCGEHIMPVTFLPCWPGSSPRMRGTLLLGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R093</accession>
    <name>A0A2Z5R093_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proton/glutamate symport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_1662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87961">
        <property type="protein sequence ID" value="BAV87961"/>
        <property type="gene ID" value="RA11412_1662"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1662"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="335" mass="35593" checksum="8F1FC26D79B7089F" modified="2018-10-10" version="1">MTVGLSYLSSIVAGFLALTAALFLYPILLKGQQLESFDNPENALSSGYVTFKLEPIMSVMSALILSFILGLGITALKSRSMLNLFEDFQVIVEKMLGYVIIPLLPVHIVGVFANMTLAGQVVKILSVFGMVFIMVILLHWFTLCIQYTAAGAVSKRNPAKMLKTMLPAYFTAIGTQSSAATIPVTVRSAKKAGIASRVVDFAIPLCATIHLSGSMITITSCAVAVLYMTGQNPSFASVTPVVLMLGIMMVAAPGVPGGGVMTAIGLLESMLGFNESMIALMIALYLAQDSFGTATNVTGDATIATFTERFSKLMGINPDSEIRDEDIEKAESISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0B8</accession>
    <name>A0A2Z5R0B8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4253 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88063">
        <property type="protein sequence ID" value="BAV88063"/>
        <property type="gene ID" value="RA11412_1764"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1764"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025349">
        <property type="entry name" value="DUF4253"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14062">
        <property type="entry name" value="DUF4253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4253" evidence="1">
        <location>
            <begin position="150"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="258" mass="28945" checksum="2C9BF78204C0F51B" modified="2018-10-10" version="1">MLTAGLTWDEVESLYGEASGDELTRHNTYPVILAVDEGLLTRIEQNVTDFMRYTGREPRPVTARSLGEYAGNIIGEYEARTLDTTTSEVAEKIFQQLERHPRVSTYKRRTDKITELFSPGFTPVDVPYCVPEALVSASATWGADTLLVLVDFPVEQPADILAHVPCVPAEAPLDTPAFYALTRYWQEYTYATLAYIDRYGIILYRQFPPESHEAMQLAAEHDLVSVGECRQANGTLDELAQSLHTQNYGRVYWGGGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0C0</accession>
    <name>A0A2Z5R0C0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">nusB</name>
        <name evidence="9" type="ORF">I6I94_00570</name>
        <name evidence="10" type="ORF">NCTC10207_01189</name>
        <name evidence="8" type="ORF">RA11412_1883</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887232.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88182">
        <property type="protein sequence ID" value="BAV88182"/>
        <property type="gene ID" value="RA11412_1883"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1883"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="6"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VEI23092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="136" mass="15537" checksum="845616180D7ACD65" modified="2018-10-10" version="1">MNSRTKARLRAVESLFEADQRGEDPVEVLQRRRLHTAAQISSYSEQIVRGVRDRREELNEYLNTYARDWSLERMPATDRVVLLIGAWELLFNDDIPDAVAISEATGLARVLSTNDSPKFVNGLLDKLRRVKPTLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0D9</accession>
    <name>A0A2Z5R0D9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycine betaine transporter OpuD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_1712</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BCCT transporter (TC 2.A.15) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88011">
        <property type="protein sequence ID" value="BAV88011"/>
        <property type="gene ID" value="RA11412_1712"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1712"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="271" mass="30502" checksum="3DE02CF171F08AFC" modified="2018-10-10" version="1">MTESVGLYMQNFFEMSFRTAAFNGDERAWIDTWTVFYWAWWISWSPFVGLFIARISKGRSIREFITVVLLIPTVLSFIWFSVFGTMANTVQQNGLENLTKLEDEQLLFGTFKHYPLGMLMSIIAIILIFTFFITSADSATYVLSMLSEDGRLIPTNGKKVVWGVIVAGIATVLLYAGGLDALRNTLIIIALPFAVVIALIVVALIVEVYHEKVQMGLSISPDRYPEKGQPFKSYESYESEDEAEKSIEDEADTSAQQVKQGKKTSEPAKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0E7</accession>
    <name>A0A2Z5R0E7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_00495</name>
        <name evidence="1" type="ORF">RA11412_1898</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88197">
        <property type="protein sequence ID" value="BAV88197"/>
        <property type="gene ID" value="RA11412_1898"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1898"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="70" mass="8335" checksum="D038D03BAD02CC31" modified="2018-10-10" version="1">MRLSPELKERYEALARHTDRPASYYMRLAMEEKIAEYEHIYLMKQEVEDYRAGKVAAIPFDDLMGHLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0F6</accession>
    <name>A0A2Z5R0F6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">secD</name>
        <name evidence="12" type="ORF">I6I94_00455</name>
        <name evidence="11" type="ORF">RA11412_1908</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88207">
        <property type="protein sequence ID" value="BAV88207"/>
        <property type="gene ID" value="RA11412_1908"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1908"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV88207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT89146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="564" mass="60019" checksum="73BFC85F950637ED" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0I1</accession>
    <name>A0A2Z5R0I1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I6I94_01285</name>
        <name evidence="10" type="ORF">RA11412_1685</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87984">
        <property type="protein sequence ID" value="BAV87984"/>
        <property type="gene ID" value="RA11412_1685"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1685"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="28"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="370"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="403"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="596" mass="64941" checksum="2CEAC9E84BEA78FF" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0K8</accession>
    <name>A0A2Z5R0K8_9MICC</name>
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        <submittedName>
            <fullName evidence="15">Excinuclease ABC subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RA11412_1968</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88267">
        <property type="protein sequence ID" value="BAV88267"/>
        <property type="gene ID" value="RA11412_1968"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1968"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="321"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="354"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV88267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="653" mass="71990" checksum="D126C07FDA066BE6" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0M3</accession>
    <name>A0A2Z5R0M3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88335">
        <property type="protein sequence ID" value="BAV88335"/>
        <property type="gene ID" value="RA11412_2036"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2036"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007331">
        <property type="entry name" value="Htaa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04213">
        <property type="entry name" value="HtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016329583" evidence="1">
        <location>
            <begin position="30"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="218"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="280"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="346"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="399" mass="43248" checksum="49304F7CBBD3FF96" modified="2018-10-10" version="1">MIIRAQRPAALLAAAALSVSTLATVPAAAAVEQAPAAVVTDAVNPAANSQVIQNATMNWGLKKSFRDYLAKPAVGSRIETTNGLARNADGTFKWSAGTGTYQNGSGTINFPGTLHITGHHGKLDMTFTNVRLQLNGREGKLILDGSSLDMQGNNHVFKDTEFATVDTSSVRVNGSTLTLNNAAVTLTPAGAQAFSGFYNKAEEYRFDPLTVNAGLRGTHAVFSDVPEGAAFYTEIQWFAQQKITTGYPDGTFRPQGNVERGAMAAFFYRMAGSPKYTAPATSKFSDVPTTHPFYKEISWMRDQGITTGYPDGTFRPNAPVNRDAMAAFFYRAAGSPAYLAPAQSPFADVSTNNQFYKEIAWLADRKISTGWPDKTYRPGNAINRDAMAAFIYRYKHLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0N5</accession>
    <name>A0A2Z5R0N5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTPase Obg</fullName>
            <ecNumber evidence="6">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">obgE</name>
        <name evidence="6" type="synonym">obg</name>
        <name evidence="11" type="ORF">I6I94_00115</name>
        <name evidence="10" type="ORF">RA11412_1999</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88298">
        <property type="protein sequence ID" value="BAV88298"/>
        <property type="gene ID" value="RA11412_1999"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1999"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="9">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="7">
        <location>
            <begin position="160"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="8">
        <location>
            <begin position="364"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <begin position="191"/>
            <end position="195"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:37565"/>
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            <begin position="291"/>
            <end position="294"/>
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        <ligand>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51881"/>
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            <dbReference type="PROSITE" id="PS51883"/>
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            <dbReference type="EMBL" id="BAV88298.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="QQT89087.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="531" mass="58087" checksum="F8658258E41780A0" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0W7</accession>
    <name>A0A2Z5R0W7_9MICC</name>
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        <submittedName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
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        <name evidence="9" type="ORF">RA11412_2013</name>
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        <name type="scientific">Rothia aeria</name>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="256"/>
            <end position="270"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAV88312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="279" mass="31995" checksum="C40BE0AA22DDE96C" modified="2018-10-10" version="1">MSENIYPKVSTFEAAGNGVSASPQFPKLEEAVLDYWKKDETFQASIDNREAGPHGDNEFVFYDGPPFANGLPHYGHLLTGYAKDLVARYQTQRGHKVERRFGWDTHGLPAELEAMKQLGMTDKQEILEMGIDNFNDAARASVLKYTNEWEQYVTRQARWVDFENDYKTLNVEYMESVIWAFKRLYDKGLTYQGFRVLPYCWKDETPLSNHELRMDDDVYQDRQDQTVTVAFTLTADDSLAANKILSLNWLALRHLPGPPPPGPYPPTRRSPSDPTLNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R123</accession>
    <name>A0A2Z5R123_9MICC</name>
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        <submittedName>
            <fullName evidence="10">MFS transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Multidrug transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I6I94_11130</name>
        <name evidence="9" type="ORF">RA11412_2073</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88372">
        <property type="protein sequence ID" value="BAV88372"/>
        <property type="gene ID" value="RA11412_2073"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2073"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="63"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="513" mass="53183" checksum="3991AFE5B46D0B15" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R138</accession>
    <name>A0A2Z5R138_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88216">
        <property type="protein sequence ID" value="BAV88216"/>
        <property type="gene ID" value="RA11412_1917"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1917"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="75" mass="7829" checksum="79E9D59D0575BA40" modified="2018-10-10" version="1">MSGHSKWATTKHKKAAIDAKRAKAFAKFIKAIEVAARMGGADIAGNPALDLAVSKAKRTRCPTTILTAPLNAVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1D0</accession>
    <name>A0A2Z5R1D0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">bPH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88547">
        <property type="protein sequence ID" value="BAV88547"/>
        <property type="gene ID" value="RA11412_2248"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2248"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012544">
        <property type="entry name" value="PHb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037063">
        <property type="entry name" value="PHb_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08000">
        <property type="entry name" value="bPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bPH_1" evidence="1">
        <location>
            <begin position="36"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="150" mass="16576" checksum="98CD2B287D91C59F" modified="2018-10-10" version="1">MDLDVIGMLAKAGNMANDGSNKGDNNVNGIAALSWTFVSECPIPPDAADLMVQGEQPFLAYKTFRDSAIFTNKRLIVRDAQGITGKKVEIYSLPYKHILMWSSENAGTIDINSELELWTKVGRIKIKLSRGADIRRLDRIISDMVLLYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1E2</accession>
    <name>A0A2Z5R1E2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1-deoxy-D-xylulose 5-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_2174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88473">
        <property type="protein sequence ID" value="BAV88473"/>
        <property type="gene ID" value="RA11412_2174"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2174"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="3">
        <location>
            <begin position="294"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="369" mass="40144" checksum="ECB819607A50C8B4" modified="2018-10-10" version="1">MAVTGGHLGPNLGVVELTLGIHRVFDSPHDNILFDTGHQSYVHKLVTGRHNFESLRQKGGLSGYPDRGESVHDIIESSHASSSISWADGISRAHKLNGQNDRYTVVLIGDGALTGGMAWEAVNNIAADRTRKVVIVVNDNGRSYAPTIGGFANQLSALKYNVQQQVDKMRLDRRYDRALNAMREKLQRGGSFGQMIYRGLHGMKAGIKDVVVPGGIFEDLGMKYVGPIDGHDQEAVETALSAAKNYGGPVIVHAITEKGHGYAPARANEDDQFHAVGPIDPLTGKEVSKSTKESWTSVFGREIKQIADEREDIVGITGAMLIPVGLREFAQAHPERVIDVGIAEQHAVAMSAGLAYGGCTRWWRFTRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1I9</accession>
    <name>A0A2Z5R1I9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_11180</name>
        <name evidence="5" type="ORF">RA11412_2065</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887986.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88364">
        <property type="protein sequence ID" value="BAV88364"/>
        <property type="gene ID" value="RA11412_2065"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2065"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="163" mass="18274" checksum="37675988F9B861D9" modified="2018-10-10" version="1">MKDSYLSREELVKFIATLPTRRLAAGAVIRNEHGELLLVQPNYKDGWILPGGTVEAGEAPKPGCFREVEEELGLRLAPGRLLLVFHGLARGVWGDSTYYMYDAGVIAKNTPVTLQTEELITYEWVAPEQLQEYVNPGFAERLHDCLRALRTGEVVEMSSDERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1J8</accession>
    <name>A0A2Z5R1J8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA decomposition enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88430">
        <property type="protein sequence ID" value="BAV88430"/>
        <property type="gene ID" value="RA11412_2131"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2131"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="210" mass="23620" checksum="D634AA68356D1487" modified="2018-10-10" version="1">MFVPRIRDDGTQDWSRGRSYSRLVVPDNLHILGTMNSTDRSVGTIDLALRRRFHWHEMEPMRKDDLKEALTAAGRDLEADPELSLLIDAYDRLNTSLKNEVGPDARLGHAYFFEPKASAPEIADALLTQLAEVAATFNIKETPHTNPDFPRKLAGISDLCGRYVEYVGHGLGRRPTLAAPGTRSWRDYTRPHKWANTAISRRESPDNAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1L9</accession>
    <name>A0A2Z5R1L9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88450">
        <property type="protein sequence ID" value="BAV88450"/>
        <property type="gene ID" value="RA11412_2151"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2151"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="53" mass="5561" checksum="20FB89B9C9658F31" modified="2018-10-10" version="1">MKRGAPAVTDAASSTAQLWPHVHGTDAMFLALFRKNNKGTGTTRGGSHSGDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1M8</accession>
    <name>A0A2Z5R1M8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88460">
        <property type="protein sequence ID" value="BAV88460"/>
        <property type="gene ID" value="RA11412_2161"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2161"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="56" mass="6028" checksum="ADBA1205C2EDDACE" modified="2018-10-10" version="1">MSGDKMDGDHGKMGGDKMQGDHDEKKHDDHKMDGDKGGKMESKDAMMSPSASAMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1P1</accession>
    <name>A0A2Z5R1P1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88446">
        <property type="protein sequence ID" value="BAV88446"/>
        <property type="gene ID" value="RA11412_2147"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2147"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="355" mass="34787" checksum="F362846521C9A2F7" modified="2018-10-10" version="1">MRCCHPQPGAERRYRICTAPGGASGNTPGTSSTVSPTVKSGGVISFNLSGFPQNTMVSVKIDDGDACPADAPQGACVVHQQKSDGNGNVSGSFVLPSDLENGQHTLRFLAAGSKKNSKGDSLGTQPFSNKSPVFTVTGGSDGGNKSGGGNSGGSSSDSGSSNNNGGGSRSNGGSRSGGNKSGGGGASNNNGGGGSSNNGGGASGDGGSSNNSGGGTSGGGTSANGGGTADSGETEYVDADGNKITKEEYDRLNSENGGDSETEGDADTSNTEDGTTTNGEKKQKSSNGTTQKKATAKANASGVNKQSNSSDKAQAKNETTNTTVTYGSEFPWIGTIVLAAAAIAAAIIVIVRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1U0</accession>
    <name>A0A2Z5R1U0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Octanoate-[acyl-carrier-protein]-protein-N-octanoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88540">
        <property type="protein sequence ID" value="BAV88540"/>
        <property type="gene ID" value="RA11412_2241"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2241"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="99" mass="10780" checksum="2914817FA153D251" modified="2018-10-10" version="1">MWVLGDEHTPDQKIAAIGIRVSKNTAMHGFAINCCNETAPFMQFIPCGITDAGVTTMSEQLGRTVTPAEILEPLERELTRYADRLAESFEPTPSAQAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1W0</accession>
    <name>A0A2Z5R1W0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cys-tRNA(Pro) deacylase YbaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88466">
        <property type="protein sequence ID" value="BAV88466"/>
        <property type="gene ID" value="RA11412_2167"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2167"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="69" mass="7319" checksum="84F6FDEC17AB2C1C" modified="2018-10-10" version="1">MFKTLLIVHDKDFAVAVVPVSGQLNLKAAAHALGWKSASMCDPKIAERRTGYVVGGISPLGQKTPSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R226</accession>
    <name>A0A2Z5R226_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6318 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_2469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88768">
        <property type="protein sequence ID" value="BAV88768"/>
        <property type="gene ID" value="RA11412_2469"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2469"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046281">
        <property type="entry name" value="DUF6318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19843">
        <property type="entry name" value="DUF6318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016292108" description="DUF6318 domain-containing protein" evidence="2">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6318" evidence="3">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="87" mass="9040" checksum="8C2B23383E58AFDB" modified="2018-10-10" version="1">MTSEITRRAALGFAGVTSLTLLAACGSGTAIKGSSSESSSAAKKDYKGEVKLEEYDTSAGTFEPATHDTPPKNVPKPIKPKTLTKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R260</accession>
    <name>A0A2Z5R260_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05340</name>
        <name evidence="2" type="ORF">RA11412_0680</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070555117.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86979">
        <property type="protein sequence ID" value="BAV86979"/>
        <property type="gene ID" value="RA11412_0680"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0680"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT90011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="68" mass="8261" checksum="3D0B073B3DA79C9F" modified="2018-10-10" version="1">MTTVFYRGERRDVKSFTPEERQDYLDKKQHTINEAKEAIAGMKARIAELERIQAMNPIRRWFYKTFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R261</accession>
    <name>A0A2Z5R261_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">secY</name>
        <name evidence="14" type="ORF">I6I94_09200</name>
        <name evidence="15" type="ORF">NCTC10207_01761</name>
        <name evidence="13" type="ORF">RA11412_2548</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="14 18" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888706.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88847">
        <property type="protein sequence ID" value="BAV88847"/>
        <property type="gene ID" value="RA11412_2548"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2548"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV88847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT88689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VEI23835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="435" mass="47583" checksum="C203513EE1464678" modified="2018-10-10" version="1">MLSAFGRVLKTADLRRKLLFTLGMIVIYRMGTFIPAPGISYGTVQQCIANNGSNHGIYDIVNLFSGGALLQLSIFALGVMPYITASIIIQLLRVVIPRFQELHDEGAQGQAKLTQYTRYLTIALALLNGTTIVSMARSGALIGNCPNIIPVDDIWHVLLIIITLCAGTTVIMWMGEQITERGVGNGMSLLIFTSIASSFPNALGAIERQQGAMVFWAVCGVGLVVMLAVVYVEQSVRRVPVQYAKRMIGRRTIGGTSTYIPLKVNMAGVIPLIFASSLLSLPGIIAQLNTPNNGSPPPEWVSWINTYLVRGDHPLYITLYFFLILGFTYFYVSVTFDPVEVADNMKKYGGFIPGVRAGKPTERYLSYVLNRITLPGSLYLAVISMIPLVALILFQANQNFPFGGASLLIVVGVGLDTLKQINAQLQQRHYEGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R264</accession>
    <name>A0A2Z5R264_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 11">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">hemB</name>
        <name evidence="14" type="ORF">I6I94_10025</name>
        <name evidence="13" type="ORF">RA11412_2351</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 11"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88650">
        <property type="protein sequence ID" value="BAV88650"/>
        <property type="gene ID" value="RA11412_2351"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2351"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV88650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT88847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="331" mass="36052" checksum="FF2213CD4062A012" modified="2018-10-10" version="1">MNLTRRPRRLRTTAAMRALTAETALRPEQLIQVFFVRDGMSEPQPISSMPGQYQHTLESLIPAVRQAAEAGIKCIDLFGVPLDDDKDEVGSAAWDENGILNRAIAACRAEFGDEIVIMADTCLDEFTSHGHCGVLVDDGYGTMIVDNDATVELYCKMAVSQARAGAHTVSPSGMMDGQIAAMRAALDTAGFQNVSIMAYSAKYASAFFGPFRDAVESSFTGNRKTYQQDPANRRESLLEVQADIDEGADMVMVKPAGSYLDIVREVAEFSPVPVAAYQVSGEYAMIEAAAANGWIDRRAVALEALRSIHRAGADMILTYYAAEAARWLRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R281</accession>
    <name>A0A2Z5R281_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88581">
        <property type="protein sequence ID" value="BAV88581"/>
        <property type="gene ID" value="RA11412_2282"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2282"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="58"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="217" mass="24256" checksum="0C2AD8E3025F1F2D" modified="2018-10-10" version="1">MKIKKMQLPPIDPNAPVVIRVDNLVKSFVLRHTRSMKEAFVWLMKGRKGDLSEKFNALNGVTIDIQQGERVALLGLNGSGKSTLLKLISGVMQPDKGKVVTRGDIAGLIEVGAGFHPDLTGRDNVYLNGAILGMSKSKIDAAFDDIVAFSEIGEFIDTEVKFYSSGMYLRLAFSVAIHTNPDIFWWMRFLRLVMNRSRRNASRRSKNCALTVRPSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2H6</accession>
    <name>A0A2Z5R2H6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88928">
        <property type="protein sequence ID" value="BAV88928"/>
        <property type="gene ID" value="RA11412_2629"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2629"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="112" mass="12568" checksum="39F99D69B55EB489" modified="2018-10-10" version="1">MPSFLISAVYTAYLVAQIIAAILYLRNRALVYIIVVNIIGALWGLYGTARLVYQIISGTAFFTEQDPQRLLAFTADKIDMVLCFLFATLAIMTFKKRRTQPQPSTENTPTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2M4</accession>
    <name>A0A2Z5R2M4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08505</name>
        <name evidence="2" type="ORF">RA11412_2718</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89017">
        <property type="protein sequence ID" value="BAV89017"/>
        <property type="gene ID" value="RA11412_2718"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2718"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="522" mass="57263" checksum="61487C68B3A951BB" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2M9</accession>
    <name>A0A2Z5R2M9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin synthesis protein BioC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09775</name>
        <name evidence="2" type="ORF">RA11412_2417</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88716">
        <property type="protein sequence ID" value="BAV88716"/>
        <property type="gene ID" value="RA11412_2417"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2417"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="58"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="226" mass="24772" checksum="D9BC99674A2813D7" modified="2018-10-10" version="1">MSSTRQNPAEQAKALASQLKCPMGDTGQELAHSLNLGNLFMIVSALNALGIEEGDRILEAGPGNGGLLNYVLSLAENLHYDGVEISPLMYEQARAANNVFIAEGLAEYALYDGVNLPYEDGIFTKVLSVNTVYFWEEPAWLLAEMCRVLTAGGRVCLSFCEKDFMKTLPFTKYGFALYDAADIVALTQELPLHTVAVQHLHDMAVAGGSARLVRRDYVNLVLEKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2X5</accession>
    <name>A0A2Z5R2X5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrate reductase molybdenum cofactor assembly chaperone</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Respiratory nitrate reductase delta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">narJ</name>
        <name evidence="4" type="ORF">I6I94_09010</name>
        <name evidence="3" type="ORF">RA11412_2595</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887766.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88894">
        <property type="protein sequence ID" value="BAV88894"/>
        <property type="gene ID" value="RA11412_2595"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2595"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003765">
        <property type="entry name" value="NO3_reductase_chaperone_NarJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43680">
        <property type="entry name" value="PTHR43680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
        <property type="entry name" value="Nitrate_red_del"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00684">
        <property type="entry name" value="narJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="249" mass="27741" checksum="E19485B06847A4EF" modified="2018-10-10" version="1">MAGFFSRLMGTAGSEDKTSDPAHPAQDNIDPFDRDFGPGQDRDSVIYQVSGMLLGYPSEELVQTLPELIRLAQATEDDEFTQAVQTVANWMTAQDLEDVQSEYVQEYDLSRRHALHLSYWTDGDTRRRGETLLKFKQMYRDSGMFTQLNGELPDYLPLVLEFAALVDRTKGRAALQAYRPSLELLRLSLKDGNLPHYGLLHSICGTLPGVSPETQEQVQQMAGYGPPVETVGLSGYADPRIAQANPNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R320</accession>
    <name>A0A2Z5R320_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Menaquinone biosynthesis related protein menX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08440</name>
        <name evidence="2" type="ORF">RA11412_2733</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89032">
        <property type="protein sequence ID" value="BAV89032"/>
        <property type="gene ID" value="RA11412_2733"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2733"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="248" mass="27768" checksum="BF5C16FFFE1AC861" modified="2018-10-10" version="1">MPTTHYQDADLFYRLSGEPENPAMLLLHGGFGSAEDFAAILPELQQHFFVVETDARGHGRSTRGTAELTYAQLAEDARHIVQVTGLREYHVFGFSDGGTAAYRLAAEDTRVLSVVTVGSSWSGVQDASVREMFENLSPALFRERMADRVASYERLNPRPHLETLVDDLRHRWLDTTETGYLNEHVSAIKVPVLAARGENDFLFSLQELAELREHLPEAHLMNVPFASHEAISEQPGIIWAAMKTMYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R355</accession>
    <name>A0A2Z5R355_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87359">
        <property type="protein sequence ID" value="BAV87359"/>
        <property type="gene ID" value="RA11412_1060"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1060"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016371097" evidence="1">
        <location>
            <begin position="38"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="275" mass="29826" checksum="740C6EE94046652B" modified="2018-10-10" version="1">MRLESFKNAKSSLPSRRLACALALTGVASLPLTPVLAEPEPLNGPGDDTQSFLPKLNLSLTENVNPYIPCTIYVEGTGFYGVQLGQRVSVYVGLTEDTSKPEYFPETIDDTHLGFVHVPAERIEDGAFKTELVTGQLWYGQYRAGLEYAVKTMISYAESTEEGHRTSETTKYDTQTPITVLTESPRLDFDKNPSAAGGSITVHGTGFESRYIPAGARLRLFINRAGLGEPGHLAPDPVSLITVGPEKINNGAFEVNIPYVSGLDTTKNTPLGCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R376</accession>
    <name>A0A2Z5R376_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88961">
        <property type="protein sequence ID" value="BAV88961"/>
        <property type="gene ID" value="RA11412_2662"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2662"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="38" mass="4499" checksum="F5512430ACECEB50" modified="2018-10-10" version="1">MERTGANEAIVMSAPWEFEDRIRNYELLSQLPIFQKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R393</accession>
    <name>A0A2Z5R393_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable conserved integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_1130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87429">
        <property type="protein sequence ID" value="BAV87429"/>
        <property type="gene ID" value="RA11412_1130"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1130"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="297" mass="32947" checksum="04CE00C7F613B1E6" modified="2018-10-10" version="1">MRPAHRIPRGFFVGIAAGIKLTPLALMLVFLARREWTSILTTTLTFLGTVVLGFILLPSQSVQFWTSAIQDTSRVGRVRELGNISFQGIISTVVPEGVLLKALYILAAVAFIVLIYVFIRLSDKMYDAYVSNYITACAALLVSAFISPISWSHHSVYIPLIIICFIVFGFSLVQKTFGKLGGGIAISLILLAGFTLLFTPIEMSKFISRVWIRLKMFPFTDILRNSSTLDESFKIAVESTPVMFVTYIPYIAMVLIYCVWVLALARRNKDKKGQSGNLTSRSSHLGNDKLAKDSMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3B5</accession>
    <name>A0A2Z5R3B5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4097 family beta strand repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08325</name>
        <name evidence="2" type="ORF">RA11412_2757</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89056">
        <property type="protein sequence ID" value="BAV89056"/>
        <property type="gene ID" value="RA11412_2757"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2757"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="30"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="210" mass="22801" checksum="757FE832CED2689C" modified="2018-10-10" version="1">MSIVVTEPKSLALEILDLETDIFATTDKNATIEVPHAELFTVRTDEGAIQLTQTEHYWQSPFATRPSLLHFLTRPRVKITVPTGTFLDALRVRTSSYCTIGGMRASYADLTAAEGTIRCRNSDFSHVQARASSASVLLANCTVDEDASLKVAGGAVLTVGTFDEMPGYRVREATGSVEIFGKQCRTGDSYDAENQPSVYITCSGGHVEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3B9</accession>
    <name>A0A2Z5R3B9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_03330</name>
        <name evidence="1" type="ORF">RA11412_1190</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87489">
        <property type="protein sequence ID" value="BAV87489"/>
        <property type="gene ID" value="RA11412_1190"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1190"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="263" mass="27704" checksum="B195F22ECF2828B0" modified="2018-10-10" version="1">MLNFQRLSQLIQGGKMAQIALVTGASRGIGKATAVRLAQLGYHVIAQHRAENPDFSEVEAAASEHGVKVTPVQADFSDPQSVSALLTHVKDVLGGDTLDVAVLNAGVGTQGTFQELNGEALRNLLQINTVAPYELAAGLVPLMSAPGGRYIFTGSVLTRYAFPAMTGYGMSKIALEYLVRNMAVELGPQGITVNLVAPGVVDTDINAAWLRDNAEAAEFVKSGNAMKKVTQPEDVAEVIGLLTQNASQTITGQIIDVSMGDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3K2</accession>
    <name>A0A2Z5R3K2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87629">
        <property type="protein sequence ID" value="BAV87629"/>
        <property type="gene ID" value="RA11412_1330"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1330"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="282" mass="29948" checksum="1221D3848712CAD0" modified="2018-10-10" version="1">MIEEIHIRDLGVITDARLPLQPGLSVLTGETGAGKTMVVTALGMLLGARSDASSVRSGAKSALAEAVVRLPHNHPALTLAQDAGGSVEELDGEQSELLLARTVNASGRSRAHIGGCSAPIGTLADIGHTLVAVHGQSDQLRLKSAAAQRHALDSYAGEALTRLLGEYRTTYDRYRAAAAELKEVRENSRARALEAQTLRGALEEIDSVDPQEGEDTALKAESLKLMNVEALRIAAATASGRWQAANTLKGTRRTCWVCLILPEGPCSTKPRPTKNWPHSLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3S4</accession>
    <name>A0A2Z5R3S4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="6" type="ORF">I6I94_01585</name>
        <name evidence="5" type="ORF">RA11412_1640</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87939">
        <property type="protein sequence ID" value="BAV87939"/>
        <property type="gene ID" value="RA11412_1640"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1640"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033776643" description="Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="387" mass="41279" checksum="8F76D8CD6D2773EC" modified="2018-10-10" version="1">MLSLVSSAAVSAVSSVPLASIPSPDVSYIQVGPLRIHFYALCILAGIAVCLWLSGRRWAQMGGTRERVYDVAMWAIPAGIVGARAYHVLITDPGSYFGPKASGDPLAFLKIWEGGIGIMGAVSVGALGAWYACRRYRMNFAAFADAVAPGIILAQAFGRWGNWFNQELFGKPTTLPWGLQIDANSPNFPSQYPAGTLFHPTFLYESLWNLLGAFLLIYLGKKGVLKLGQTLWLYVLYYGVGRLFIEAFLRIDTSEMLLGLRIHVWTAGLLVVLGLTGFIVAGVRASAKAAAGVTDGPVEERGTAENPSDVLETGSKDAAEDDAASTGEKADDKKKAVKKTENTSNVSLAKGMSKAKAVYNSAAETSGEAQGRPSQPKKETTDDSDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3X8</accession>
    <name>A0A2Z5R3X8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome aa3 subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I6I94_00855</name>
        <name evidence="10" type="ORF">RA11412_1810</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887270.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88109">
        <property type="protein sequence ID" value="BAV88109"/>
        <property type="gene ID" value="RA11412_1810"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1810"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="9">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="212" mass="23494" checksum="7BFAA132310AE4B7" modified="2018-10-10" version="1">MTTVTVNPKKPAHPALNRPNTVAIGTVVWLASELMFFAGLFAMYFTLRASRPDIWEDNVHKLNVTFALINTIILVLSSVACQMGVFAAEQLKPRRTGSLLNVKAWGMAEWFVLTFIMGAIFVAGQAYEYATLVSEGVTIASSAYGSAFYITTGFHALHVTAGLVAFLLIIGRAYVAKRFGHYEATSAIVVSYYWHFVDVVWIALFFVVYFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3Z3</accession>
    <name>A0A2Z5R3Z3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88149">
        <property type="protein sequence ID" value="BAV88149"/>
        <property type="gene ID" value="RA11412_1850"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1850"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="181" mass="19819" checksum="24C5B85B12E5CCAD" modified="2018-10-10" version="1">MLKQGIQHAVFVETHEAQVPHTRRYPLALTSYDEQLTAVPGIGVEMHTGPVSPTTILAHQAQQAGLGRSLTLRVGIPGYLSAEAQNPRAVVDMIKALEKILGITVDSEEYTELQAKADSWEQELADEMADDFEKVEIVREYEQRVDESLQSVSGEELANDIEEFLGTLTDDTSGGADGHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R413</accession>
    <name>A0A2Z5R413_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_00485</name>
        <name evidence="1" type="ORF">RA11412_1900</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88199">
        <property type="protein sequence ID" value="BAV88199"/>
        <property type="gene ID" value="RA11412_1900"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1900"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="175" mass="20730" checksum="F87C061AD4D544CA" modified="2018-10-10" version="1">MRILIAGTSGSGKTTFAQRLGAILGIPHTEMDSLYWGANWTPRPSFEADVDELAAQDSWITEWQYSQVRERLLERADTVIYLHYPRWFVEQRVIRRTLHRAVTREELWAGNTEPPLWSVFTDPENMIRYTWSSYPKYEPLMAEARRKHPDKRYIEFRTPREAEKFLQAVQLRGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R439</accession>
    <name>A0A2Z5R439_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88269">
        <property type="protein sequence ID" value="BAV88269"/>
        <property type="gene ID" value="RA11412_1970"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1970"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="2"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="232" mass="25498" checksum="5EC7DEA3185A6041" modified="2018-10-10" version="1">MDNSVYLLTMRHSGEQLLIDPADDAEALYAFTLDALLHDCPHLELTDAQDHRVRVIESEADFEAVRQRAIGVTSIVVTHGHWDHIRAINGLEKFTGAITSAGAEDIEAIHELEGFEVEESLMGGETFDFYGSDTVVRTISVPGHTPGSIVYVLESVWEDGSPATLLFTGDALFPGGVGKTDSRQQFGELFTNVLEKLFGAFDDDTTVLPGHGRSTTLGEERPHLEEWGERGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4Q6</accession>
    <name>A0A2Z5R4Q6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_09615</name>
        <name evidence="1" type="ORF">RA11412_2450</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88749">
        <property type="protein sequence ID" value="BAV88749"/>
        <property type="gene ID" value="RA11412_2450"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2450"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="153" mass="16713" checksum="D4DFF0477201BBCA" modified="2018-10-10" version="1">MATNQLKDWFSYLNGVSSDLPTEPLKCIEARDGVLAWAISDITEEPTRNEIAGILAGLDASRVNADRVDRVRRALAEHYLATDSGRAIAASAYLEWLTGRYELAALALRTAFSDGHDNNLLQLVSRALAMGVSSPLYPEMPPLSVLHLQEAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4R2</accession>
    <name>A0A2Z5R4R2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88769">
        <property type="protein sequence ID" value="BAV88769"/>
        <property type="gene ID" value="RA11412_2470"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2470"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="65" mass="7111" checksum="54D2702EC6A9093D" modified="2018-10-10" version="1">MESRHGAFRVDVTETSTERSVKVSTIPTSQQVSKGSGKIKAKYTGGRWVIDIEFDESSSSPSPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVC7</accession>
    <name>A0A2Z5QVC7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable ATP-dependent helicase lhr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86345">
        <property type="protein sequence ID" value="BAV86345"/>
        <property type="gene ID" value="RA11412_0046"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0046"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="31"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="337" mass="36368" checksum="C188EF8E66BFD10A" modified="2018-10-10" version="1">MPDALAPFSPATQQWFRNAFGTPTAAQEGAWESISKGENALIIAPTGSGKTLAAFLWALDALYRDKSTEPGQRELTTSAQAQKNGDARETHKTKKKRAGGTRILYVSPLKALGADVERNLRAPLAGIAHTAKESGRTPPDITVGIRSGDTPARERRQLISNPPDILLTTPESLYLMLTSAARSTLTGVTTVIVDEVHALAGTKRGAHLAVSLERLDQLVERPVQRIGLSATVNPPEAVATFLGGVHPVTIVARQVPKRWDLRLSVPVPDMAALGGANDYGQGSYAPGSNGHRAGRIRPVQPRTPRICRFRQPMMRHPILLRMLLAPSPVKKDYLLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVG0</accession>
    <name>A0A2Z5QVG0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="6">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purD</name>
        <name evidence="9" type="ORF">RA11412_0071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86370">
        <property type="protein sequence ID" value="BAV86370"/>
        <property type="gene ID" value="RA11412_0071"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0071"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="109"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="429" mass="44742" checksum="D4B10D52482C15CA" modified="2018-10-10" version="1">MYMKVLVLGPGGREHAIIRALARDPQVTEVHSAPGNAGIAQDVPVHAIDANNPEQAVTLARELAADLVVIGPEAPLVAGVSDALREAGFAVFGPSAAAAQLEGSKAFAKQVMEEANVPTARAFVATTEAEAAQALDEFGAPYVVKDDGLAAGKGVVVTENRDAALEHANACFAAGGSVVIEEFLDGPEVSLFVISDGKNVLPLSPAQDFKRIFDNDKGPNTGGMGAYTPLDWLPEGFVGEVIEKIARPTITRMAERGTPFVGVLFCGLTVTSRGVRVIEFNARFGDPETQAVLARLRTPLGQLLLAASRGEIAEDTHLEWDPRTAVDVVMAAENYPGTPRKGDAIAGLENASNVPGVHVVHAGTAVAGEEIVTAGGRVLAVVALGDTLAQARDAAYEGVHAITWEGAQYRTDIALKAVQGAITVPELRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVT8</accession>
    <name>A0A2Z5QVT8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86508">
        <property type="protein sequence ID" value="BAV86508"/>
        <property type="gene ID" value="RA11412_0209"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0209"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="93" mass="10390" checksum="A76B7FAC75DFEFD6" modified="2018-10-10" version="1">MSGQRARIFEDGFSEHGYVLDIGGAEQSHVDAADATVVFYEYLRRIANVLDVLAPPREPVTALHLGPGRSRLPAMCRPRARVLRKWPSIMSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVU8</accession>
    <name>A0A2Z5QVU8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86527">
        <property type="protein sequence ID" value="BAV86527"/>
        <property type="gene ID" value="RA11412_0228"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0228"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4203" checksum="9E48D25574841966" modified="2018-10-10" version="1">MVYAPSAAVRWGNDGLKMLKNFISGGTAPKNLLKPSGAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVV3</accession>
    <name>A0A2Z5QVV3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07360</name>
        <name evidence="2" type="ORF">RA11412_0212</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86511">
        <property type="protein sequence ID" value="BAV86511"/>
        <property type="gene ID" value="RA11412_0212"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0212"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
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                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="RA11412_0249"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QQT88308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="41" mass="4600" checksum="F0725C02747EA3B8" modified="2018-10-10" version="1">MTDIHGNLLWYGEYTAWGRLKKDGRGLQERASAVPTAKPVL</sequence>
</entry>
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    <accession>A0A2Z5QVX4</accession>
    <name>A0A2Z5QVX4_9MICC</name>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">JCM 11412</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="48" mass="5752" checksum="197A413B8B5FD1BD" modified="2018-10-10" version="1">MKNVVRYISKFEKDTDIFIEVLKFKNEPPLDVLQKFLMKLALCMMNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW89</accession>
    <name>A0A2Z5QW89_9MICC</name>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86651">
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        <property type="gene ID" value="RA11412_0352"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="99" mass="10206" checksum="8A3D454557109C70" modified="2018-10-10" version="1">MDTVVGGAKKFGGAVCDAAGKYAGADSQACRKVVDGTAEKAGEAAKDPVGTAVKTALEGPINDFLISLWTGAVNFFQTFISSWIHAGPVISLEKTQWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWC2</accession>
    <name>A0A2Z5QWC2_9MICC</name>
    <protein>
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    </protein>
    <gene>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT88198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86691">
        <property type="protein sequence ID" value="BAV86691"/>
        <property type="gene ID" value="RA11412_0392"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
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        <location>
            <begin position="318"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="EMBL" id="BAV86691.1"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <name>A0A2Z5QWC7_9MICC</name>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="BAV86717">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="68" mass="7326" checksum="A2FE3822EEC4A7E8" modified="2018-10-10" version="1">MHRCFAGVVDNEVEDGGGDDAAARRSNGDDRGARGFEIANNEFFLSSRPVRKKKTTSNPSAAQVPTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWC9</accession>
    <name>A0A2Z5QWC9_9MICC</name>
    <protein>
        <submittedName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_06490</name>
        <name evidence="1" type="ORF">RA11412_0397</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86696.1"/>
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    </dbReference>
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        <property type="protein sequence ID" value="QQT88196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86696">
        <property type="protein sequence ID" value="BAV86696"/>
        <property type="gene ID" value="RA11412_0397"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0397"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="161" mass="17829" checksum="C153A16FF016B7FC" modified="2018-10-10" version="1">MTTAQIKFLETDPSMISAETTLRAAASDVYALIADPARHAELDGGGSVRGLVSGDTPELREGDTFTEKMFLGIPYRMSPTVVRAEKNQALSWRMPADHYWTWEIADNHDGTVTVRETWDASEAKIFGFIPAAPVFRTVGAFARNRRNIALSLAKLHRTFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWJ7</accession>
    <name>A0A2Z5QWJ7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86750">
        <property type="protein sequence ID" value="BAV86750"/>
        <property type="gene ID" value="RA11412_0451"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0451"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="4193" checksum="8FAD7D9E80044684" modified="2018-10-10" version="1">MLRGRQWITDFRKDRLHTNAYSVLLGWCTGTGGAIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWL2</accession>
    <name>A0A2Z5QWL2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86817">
        <property type="protein sequence ID" value="BAV86817"/>
        <property type="gene ID" value="RA11412_0518"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0518"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="64" mass="7099" checksum="4B6FFF795256D7CE" modified="2018-10-10" version="1">MGLFFSSGDYFYILPTLDNINSTLPTGAAGEVLILVLVFAVPIAELVFSGIFIKHSLWMIRNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWR2</accession>
    <name>A0A2Z5QWR2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aquaporin family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Glycerol uptake facilitator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_05830</name>
        <name evidence="8" type="ORF">RA11412_0559</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86858">
        <property type="protein sequence ID" value="BAV86858"/>
        <property type="gene ID" value="RA11412_0559"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0559"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="322" mass="34581" checksum="08F0EBF61F0AED36" modified="2018-10-10" version="1">MHTISPYLAEFLGTLIMCAIGCGSIATVELRRSKGHGDNFFTIAFGWGFAVAFGVYASHPYSGGHLNPAVSVGLAAFGEFEWAKVPGYVIAQLLGAMAGAGLVYLNYLPHWKATADQKIKLGVFSTVPAIHNYFTNALSEIIGTFMLVFSALYTGVNFKPTITTGSVELSLNLNDVLKPLAFGFMVAVLVVGLGGQTGYALNPARDLGPRIMHALLPIHGKGTSRWFYSWVPIFAPLVGGFMGGAFFKLYYESEFTLWVVISSACAAVLLGFAYWANSHLYRAPSAEVIPQGEDTFATAAKAAATYTATGSIPIIEKRTYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWU0</accession>
    <name>A0A2Z5QWU0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86882">
        <property type="protein sequence ID" value="BAV86882"/>
        <property type="gene ID" value="RA11412_0583"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0583"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="289" mass="31526" checksum="507ABB2643D59EFC" modified="2018-10-10" version="1">MAIGDYIKYKTGLSQRALAAELGMNHNAIQRRFSGAGVMDVETLVKIADRYSLDLLDLMVESGLITADRANSLRVGGSIRDVSNEDLMGEVLRRMNTTPVSPATPQPAAVPASAQPTPQPPPAAVHPPQQRTNTPPTTTPSRQNAANPTTVRRDSSVPNYDPYTHAHALGVDIIWGTPGQGILGRYDHASRTIILREGMLTRQERSVLAHELVHATRGDEHDAWDALYSARRERACDLKAAENLIDPVILRRAAAFYPDNLSALAYELDVTDELLAIYLDAHPFTAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX31</accession>
    <name>A0A2Z5QX31_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86988">
        <property type="protein sequence ID" value="BAV86988"/>
        <property type="gene ID" value="RA11412_0689"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0689"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="146" mass="15467" checksum="539239AF8C8C9548" modified="2018-10-10" version="1">MGIGAGELTFPRFAGALGALNITDCTGDALEFSRLAVEYARGGAPSRGIAVMARDRSLAEMATGSARLLYRVCADRTEAEWRVVRLLVPGVRGQQKAAAAALGITTQAVSRALVRSLWHEEQAARATVVNLLDRMDVAEPSVIAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX32</accession>
    <name>A0A2Z5QX32_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Manganese ABC transporter SitA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_0683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86982">
        <property type="protein sequence ID" value="BAV86982"/>
        <property type="gene ID" value="RA11412_0683"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0683"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016295940" evidence="5">
        <location>
            <begin position="44"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="321" mass="34937" checksum="F845C03D21E4BC23" modified="2018-10-10" version="1">MFTPLAFITRHNTHNAARRIRIAALAMFSVFILLLTACSGAGPASSGNGKKTVLTTFTVLADIAKNVAGDHLNVESLTKPGAEIHEYEPTPSDIKKAHSANLILDNGLNLETWFAKFVQEANAPHATVSEGVTPMNISEDAYAGKPNPHAWMSPKNVQKYVDNMVTEFSKLDPDHAEDFKKNAENYKRQLQDVQDELSNEVRTLPENQRALVTCEGAFSYLAADAGLKEKYIWAVNSEQQATPSQINSAIDFVKANKVPAVFCESTVSDNPMKQVADATGAKFGGVLYVDSLSDANGPVPTYLEMIRHDAKTIVKGLTGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX76</accession>
    <name>A0A2Z5QX76_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87047">
        <property type="protein sequence ID" value="BAV87047"/>
        <property type="gene ID" value="RA11412_0748"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0748"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="140" mass="15060" checksum="D4EB67FE3AA49EA6" modified="2018-10-10" version="1">MPVPDEPPQSNKKVNFGVRLIYIYVGCLVVGLIVDFLPGYQNDGDRVGEVISRGAPLVVNMLITAVSITVAIVVATFYKKGYTAARITAGVLAIVQGLFLLMQVALATVAILVAWTLISDADKDNVFRVASENPWLLLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXB0</accession>
    <name>A0A2Z5QXB0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Alkanesulfonates transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_04890</name>
        <name evidence="7" type="ORF">RA11412_0786</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87085">
        <property type="protein sequence ID" value="BAV87085"/>
        <property type="gene ID" value="RA11412_0786"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0786"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="112"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="310" mass="32414" checksum="E10449408CC03CC2" modified="2018-10-10" version="1">MSVTLDKISNAPELSDTPKHTKSAAAETAAARTAAASTAAGRTQLASSHRGQPRPRRALPLGAKHYVGLILPAALIMLWYVLSTAGVFTAVQLPAPTRVIAAGTELAQRGELATHLVISTQRVVLGFSIGAVLGLFLGAIIGLWGPARIAAAPTIGALRAVPSLAWVPLLLLWIGIGENSKVTLVAIGAFFPVYTTVSAALAHVDPKLVEAARAFGYRGVKLFTTVQLPAVLPSVVSGLRLALAQAWLFLVAAELLGASMGLGYLLTDSQNNGRTDRLLLAIVLLAVLGKLTDALIGVFERWVKAKYPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXD9</accession>
    <name>A0A2Z5QXD9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87041">
        <property type="protein sequence ID" value="BAV87041"/>
        <property type="gene ID" value="RA11412_0742"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0742"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="182" mass="20041" checksum="A193C65D7C64E2BA" modified="2018-10-10" version="1">MVPVIPVVPVMPVAQYPAALPNVSPQALARGQRGLRNTLCVRLLVLAVIALIETSIIAQYTREMAMAFGVLAVLYAVVQVWPLIRPPRNNSDASVYIAWGVFSMISFVGVGLLLAPITLMLLVLDWRGISLGMDPMLILCVLAVLWLLEVILLSVTLYRFGSLRMMLTQQAPLMDYLNTHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXI5</accession>
    <name>A0A2Z5QXI5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome-associated heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_0645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86944">
        <property type="protein sequence ID" value="BAV86944"/>
        <property type="gene ID" value="RA11412_0645"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0645"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025708">
        <property type="entry name" value="HSP15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016821">
        <property type="entry name" value="HSP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV86944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="129" mass="14596" checksum="C15BC018E6CCCAA0" modified="2018-10-10" version="1">MGSMSEEITSARIDVWLWSVRIFKTRALAADECKGGHVRVNDASAKPSQKLKRGDIVRVRYPGWERVFKVEKLITKRVGAPIAVTCYEDLSEPRPAHLSMPPVAKRERGTGRPTKKERRALDELRGRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXN7</accession>
    <name>A0A2Z5QXN7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical nudix hydrolase YeaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87202">
        <property type="protein sequence ID" value="BAV87202"/>
        <property type="gene ID" value="RA11412_0903"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0903"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="146" mass="15564" checksum="37176AABD7896EEE" modified="2018-10-10" version="1">MLNTLNTAAEQARDALANLAAGKLDFKIDSLMRYASNSKLSKEAAVLVLFGVLDDEPSASADFDGCPECVGENLDVLLLVRADTLRSHAGQPAFPGGKIDPEDYELARQQRVPVGRIAALREAVEETGLDPAGVEILGSCRPCRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXR0</accession>
    <name>A0A2Z5QXR0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87247">
        <property type="protein sequence ID" value="BAV87247"/>
        <property type="gene ID" value="RA11412_0948"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0948"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="174" mass="19792" checksum="E22E99FFF9DAB3B6" modified="2018-10-10" version="1">MIPIVRVPGVQTAAEKAAAKKRKTQNLVKYLAVGRTLYTVIPLALFFLLVERRAITIDAFPDLLSPVGLFLLLYVLFEILSVLWFNSGKQPAFIALLGRYLAGVVLSVVFMSIVLQFMPWSQNLRETFVGWWTITVPFAELITSGFLFYLTFKNFPKTAAAPEHTQFWQDEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXR5</accession>
    <name>A0A2Z5QXR5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87116">
        <property type="protein sequence ID" value="BAV87116"/>
        <property type="gene ID" value="RA11412_0817"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0817"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="108" mass="11896" checksum="76C67BF31564B668" modified="2018-10-10" version="1">MAITPANIKRCTLTWDAPDYSTSYPAGYTERGVAVIAVAEEAQQAQGFCYSSTATLVYVSKESGERIPLNTEPILGEHAHSLMEPCEVVHTKMLGRAVLEAWELIPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXS7</accession>
    <name>A0A2Z5QXS7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87258">
        <property type="protein sequence ID" value="BAV87258"/>
        <property type="gene ID" value="RA11412_0959"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0959"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="217" mass="24380" checksum="4E93993635CBFAF4" modified="2018-10-10" version="1">MSHQQRHDRYTAALALLGSPEAIIRLGGALALVELADDWLTDETDPQEYGRRKAQTIITTLCAYICSPFQLAHDYERLMGDQPQGLPPQQARRFRAEKTELAAEAQVRGRILTEIHDRVRWEPSDGGQPATNTAPDPEKVTAGLWSHLRFDFSGAVFFYPVDFTQSYWGAGANFRGCTYRDQARFTRSIYGADALFDRSVYHGEAFLSDSVYRAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXT3</accession>
    <name>A0A2Z5QXT3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87044">
        <property type="protein sequence ID" value="BAV87044"/>
        <property type="gene ID" value="RA11412_0745"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0745"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
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            <begin position="56"/>
            <end position="90"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="90" mass="10144" checksum="6C994A98F4825FF2" modified="2018-10-10" version="1">MLAPKYSGTVNMVILLTIVSTVFSVIAIVLLWLPGTLQYYKETALYRQAQAGQAAPQFPVQPQQPMPPQQGYIQQYGQQHPNQPLQYPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXV1</accession>
    <name>A0A2Z5QXV1_9MICC</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">RA11412_0841</name>
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    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
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        <property type="project" value="UniProtKB-KW"/>
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            <end position="662"/>
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            <begin position="177"/>
            <end position="191"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="738" mass="76034" checksum="479B8B7974FB5F07" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
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    <name>A0A2Z5QXW1_9MICC</name>
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        <submittedName>
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        <submittedName>
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        <submittedName>
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        </submittedName>
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    <gene>
        <name evidence="4" type="primary">lutC</name>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
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    <reference evidence="4 6" key="2">
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
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    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="VEI22260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="BAV87166">
        <property type="protein sequence ID" value="BAV87166"/>
        <property type="gene ID" value="RA11412_0867"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0867"/>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="109"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF02589"/>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="EMBL" id="VEI22260.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="214" mass="23509" checksum="0C7A5B15E328C640" modified="2018-10-10" version="1">MSSAKEDILARIRTSLADAPVAPEPQRNYRRVSHLNQEQTIEMLVDRLIDYKANVFEATEANIADVIAERLGETSHYVVPVGLNRQWLPEDTPTRTCFTDSGSTLEPGALTVHQLDAVDAVVTSSTVSCAETGTIFLNSNQDEGRRAISLVPDHHICVVPRSTVVELVPEAIDRITYERPVTMISGPSATSDIELIRVEGVHGPRTLDVIILDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXZ4</accession>
    <name>A0A2Z5QXZ4_9MICC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria (DUF2218)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NCTC10207_00281</name>
        <name evidence="1" type="ORF">RA11412_0805</name>
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        <dbReference type="NCBI Taxonomy" id="172042"/>
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    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">NCTC10207</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87104">
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        <property type="gene ID" value="RA11412_0805"/>
    </dbReference>
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        <property type="entry name" value="UCP028291"/>
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    <dbReference type="Pfam" id="PF09981">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="EMBL" id="BAV87104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <sequence length="111" mass="12580" checksum="B74AFDD9CAA30AEA" modified="2018-10-10" version="1">MSEYPPAESLPVRQRAVVATERPARYVKQLGSHMGRKIDTAELPGGLRLTFNRDGIFRGYGDLLIDEANNALIMEVRAEDEEKATNIAGVLDRHLVRFGERDELVVEFRRV</sequence>
</entry>
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    <accession>A0A2Z5QY13</accession>
    <name>A0A2Z5QY13_9MICC</name>
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        <submittedName>
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        <name type="scientific">Rothia aeria</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87355">
        <property type="protein sequence ID" value="BAV87355"/>
        <property type="gene ID" value="RA11412_1056"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1056"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
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    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="231" mass="24418" checksum="7718E880F8547277" modified="2018-10-10" version="1">MSATNTAMIPVITVHGIAAEPGVTPAPSVYERSLIDSLAAQSLPEHIGVLVDGNRRWAAQRGLSTREGHAAGAERIIDFLGWCTELNIPRVTLYMLSTENLKRPAGELSGLISVIDEFLNRLVASRVGPVNAVGNIAMLPQSLRATLEQAITATSTLPGVQVNIAVGYGGRQEIADAVRELLRDAAAAGTSVQELAASLNVTDINQRLYTRGMPDPDLLIRTSGSSASRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY32</accession>
    <name>A0A2Z5QY32_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">RA11412_1076</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87375">
        <property type="protein sequence ID" value="BAV87375"/>
        <property type="gene ID" value="RA11412_1076"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1076"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="61"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV87375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="124" mass="13286" checksum="00321099F31491D3" modified="2018-10-10" version="1">MFLAAAELSLGADIAPAAECRAATGLLACPDGGTVDIWEAAADIYGTGGEEGELAWQAEALCAQTDPEAFFPEKGGSTRDAKRVCGVCPVREECLKYAMDNDERFGIWGGLSERERRRLRKQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY82</accession>
    <name>A0A2Z5QY82_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PqqD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_03580</name>
        <name evidence="1" type="ORF">RA11412_1119</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87418">
        <property type="protein sequence ID" value="BAV87418"/>
        <property type="gene ID" value="RA11412_1119"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1119"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="96" mass="10740" checksum="9F397AD2EFA2C726" modified="2018-10-10" version="1">MAQLRYRIPEHIAYVHTDEFAKYSPTASYLADLRTSSIAVLEGSASIIWGVFEIPLTLPEAIEEIAELAEQDPAAIAEQVQDFVADLVSREYLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYH8</accession>
    <name>A0A2Z5QYH8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87525">
        <property type="protein sequence ID" value="BAV87525"/>
        <property type="gene ID" value="RA11412_1226"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1226"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="54" mass="5962" checksum="1A860DB95CB90B26" modified="2018-10-10" version="1">MYGAIYLGLHEPTAPPVLFYVLAVLAPVIFTGLTVVRYVRRRGGCMVCGKEICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYJ5</accession>
    <name>A0A2Z5QYJ5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">folD</name>
        <name evidence="10" type="ORF">I6I94_03980</name>
        <name evidence="11" type="ORF">NCTC10207_00473</name>
        <name evidence="9" type="ORF">RA11412_1015</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888049.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87314">
        <property type="protein sequence ID" value="BAV87314"/>
        <property type="gene ID" value="RA11412_1015"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1015"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="122"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VEI22398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="292" mass="30943" checksum="3D706934F62F4CF2" modified="2018-10-10" version="1">MPQILDGKATAAAIKNELTERVEALKARGITPGLGTVLVGDDPASHSYVGAKHRDCAEIGINSIRVDLPADITQEQLEAEIDKLNHDPACTSYIVQLPLPKHLDTNRILEKIAPEKDADGLHPTNLGKLVLNVSEPLDSPLPCTPNGVIELVKRHGIDWNGKNVVVLGRGITVGRPLGLLLTRREINATATLAHTGTQNLDEVLRQADVIVAAVGVPHVLKADQVKDGAILLDVGVSRAEDPETGKKKLFGDVSPEAAAKASWVSPNPGGVGPMTRAELLVNVVETAERQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYP2</accession>
    <name>A0A2Z5QYP2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87473">
        <property type="protein sequence ID" value="BAV87473"/>
        <property type="gene ID" value="RA11412_1174"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1174"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="4087" checksum="1241EE1D334EDC65" modified="2018-10-10" version="1">MVLLPIILTLGFVLSPPVTPKGRRVLPVLRPLDRPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYP4</accession>
    <name>A0A2Z5QYP4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">50S ribosomal protein L25</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">LSU ribosomal protein L25p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_03540</name>
        <name evidence="6" type="ORF">RA11412_1131</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87430">
        <property type="protein sequence ID" value="BAV87430"/>
        <property type="gene ID" value="RA11412_1131"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1131"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="94" mass="10605" checksum="9727923B6118D1AA" modified="2018-10-10" version="1">MSEIKITAEPRPDFGKGYARRIRAAGNIPAVIYGNGKEPKHVILPGHETTLAVRNKDAVLVIEVDGEQFKTRVQDIQRHPIRPELQHIDLLFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYQ8</accession>
    <name>A0A2Z5QYQ8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferrous iron transport periplasmic protein EfeO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EfeM/EfeO family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87605">
        <property type="protein sequence ID" value="BAV87605"/>
        <property type="gene ID" value="RA11412_1306"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1306"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd14656">
        <property type="entry name" value="Imelysin-like_EfeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018976">
        <property type="entry name" value="Imelysin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034981">
        <property type="entry name" value="Imelysin-like_EfeO/Algp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038352">
        <property type="entry name" value="Imelysin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09375">
        <property type="entry name" value="Peptidase_M75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase_M75" evidence="4">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="204" mass="20611" checksum="889D03C3A7CF1369" modified="2018-10-10" version="1">MHSEKFAQELKVDDITNGAKELLDEIVHTKTTGEEENWSHTDLYDFQGNIDGAKVAYENVRPILEKKNGKLSKNIESKFAAVQTLLDKHKSGDDFKSYKELSETEVRELSDAVGALAEPLSELTAAVVDETGNDTSTENESAGASASASASAGASHSAGASGSASAGASGSASATGSSGASAGSSASAGSTSDDSSASAAGSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ38</accession>
    <name>A0A2Z5QZ38_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_1446</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87745">
        <property type="protein sequence ID" value="BAV87745"/>
        <property type="gene ID" value="RA11412_1446"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1446"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="146" mass="15875" checksum="A123E518245DAD46" modified="2018-10-10" version="1">MVAVVDMAVVTMLGVWLFGVPFNGSLWLFSLAALIFLFVVLGIGVFISSISQNTGQAIQMAILFMVPQVLLSGLIFPLTSMPLGVRWIGYALPLTWFREIAQGIMLRSVTLEGIWLPFVILAAMAVVVFGAATARMRYILTHGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZB5</accession>
    <name>A0A2Z5QZB5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arogenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87641">
        <property type="protein sequence ID" value="BAV87641"/>
        <property type="gene ID" value="RA11412_1342"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1342"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="220" mass="24108" checksum="ED9B658DE3838FF7" modified="2018-10-10" version="1">MPLRQVLESGADASRYVGSHPMAGREKSGPVAARGELFQARPWIICEHEAARAECVKLVRALAVELGAIVTALSASEHDETVALISHVPQAVSSLLATRLQHTPLYALSLAGQGLRDTVRIAGSDPRLWVQIFAANAEPMVRTLYGIRQDLDRLIATLENPTAPGARLDLAQLMSEGNAGWLASPVNMVRCRPHLPRSRCWWMIPLGLWRGCWPILVSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZE3</accession>
    <name>A0A2Z5QZE3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AttM/AiiB protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">N-acyl homoserine lactonase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_02325</name>
        <name evidence="2" type="ORF">RA11412_1434</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87733">
        <property type="protein sequence ID" value="BAV87733"/>
        <property type="gene ID" value="RA11412_1434"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1434"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="46"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="287" mass="32059" checksum="8BDA4F4E6B0D8E79" modified="2018-10-10" version="1">MTEVQLTILHTGTVLVDQALPYHRDTDPPLAWTHLLRPQSALVDIPVSCYLIENQHGLTLIDTGWHTDNRTRWGQMKNLRHQYPVNKANLPAGQAIHEQLEERGIRPHDLDLVLMSHLYCDHADGLRLVKEAPRILVSEAEFRAAQKDRIRYLPHQWKGVNLQTYTWNSRVGERQAYDPYGDGSVVMVSAPGHSPGLTATLVRGTDTVPNAEPGVIGNDLRKYILLTSNVGFGRPSFEERLRPGVVTDAKAAFSSLDWACAAGADPRCIAMYANHDPEVDPGTRVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZG3</accession>
    <name>A0A2Z5QZG3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87862">
        <property type="protein sequence ID" value="BAV87862"/>
        <property type="gene ID" value="RA11412_1563"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1563"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="146" mass="16840" checksum="35116C57BA83E8B4" modified="2018-10-10" version="1">MVTDFAPVDLVLQRLGRLHRHERDDSERPKEYLSPICYVRGIETFGSEAQVPEFPKGSRLVYEPAILLSSYARLLPYFAGKTLRIPADMSGLVQEAYKECPEYPEAWDGVYKEAREESDKHQKCASVMAESFLLKRPQNQQQSWQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZH6</accession>
    <name>A0A2Z5QZH6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-nitrophenylphosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">HAD-IIA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_02765</name>
        <name evidence="1" type="ORF">RA11412_1325</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87624">
        <property type="protein sequence ID" value="BAV87624"/>
        <property type="gene ID" value="RA11412_1325"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1325"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="354" mass="37149" checksum="3719385F8D6CDFC3" modified="2018-10-10" version="1">MSETLLSGYDALLSDLDGVVYAGPFAIPGATEALNRAEDSGTPVVFVTNNASRSVDSVAEHLRELGVKTRADRVVSSAQASAALLAQQLPAGANVLVTGTDALANCVREAGLTPVRSQHENPVAVVQGFNPRLIWEDLAEASYTLVDEQVLWVATNTDKTIPKERGQAPGNGTLVAAVATATGRTPQVAGKPEAAIFETAAASVKAQKPVVVGDRLDTDILGANRAGMHGAIVLTGVQTYADVIAAVPDQRPVYILRTLDDFFAPYPNIEVVFEGYETAAYGPRWQANVRGEHIQLTAPEGFSTTAAHKNFAGSDDEAEAWRVACAAWWAAHPDRGGMPEVHGLPNASGSEGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZK9</accession>
    <name>A0A2Z5QZK9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_1401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87700">
        <property type="protein sequence ID" value="BAV87700"/>
        <property type="gene ID" value="RA11412_1401"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1401"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="96" mass="10460" checksum="F1A27F391B673AB8" modified="2018-10-10" version="1">MLWLAGTRNRTMWVLVGFALVLAIFAVVMSENRIQRVFGAAGVCDGATCDQSNAGKVALATGGLWGVGLGQSRQKYNYLPEAHNDYILRLSARSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZL7</accession>
    <name>A0A2Z5QZL7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87898">
        <property type="protein sequence ID" value="BAV87898"/>
        <property type="gene ID" value="RA11412_1599"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1599"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="1015"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="1077"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="1198" mass="128181" checksum="0F6201B598565E97" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZN2</accession>
    <name>A0A2Z5QZN2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diaminopimelate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87751">
        <property type="protein sequence ID" value="BAV87751"/>
        <property type="gene ID" value="RA11412_1452"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1452"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="2">
        <location>
            <begin position="17"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="143" mass="15528" checksum="2C9EE53CC1EE2719" modified="2018-10-10" version="1">MTLYTVGTIKNVSIEDEHGQIRVRRYVSVDGGMSDNARPVLYDADYTVTLANRAPAGEQVLSRVVGKHCESGDIVVRYCYLPADLQAGDILAVPATGAYCYVLGSNYNYLSRPPVIATSAGEAAHPIIRRQSEDEMLALDTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZQ0</accession>
    <name>A0A2Z5QZQ0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rrf2-linked NADH-flavin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87975">
        <property type="protein sequence ID" value="BAV87975"/>
        <property type="gene ID" value="RA11412_1676"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1676"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="2">
        <location>
            <begin position="7"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="213" mass="21835" checksum="726FEA3577388608" modified="2018-10-10" version="1">MNIAVIGATGMVGERTVTEATARGHQVEGYSRSGQAVAGAEGTAVDLSNTGELVTIINSHDVTIIAVSAGRGVSAEPVIQAHKALIAAKPSGRLLIVGGAGSLEDAKGQRFVNSAGFPEEYKAEALAFCQILDEYRASAGLTWTMLSPAFNIAPGKRTGAYNTALDNPAGEAISAEDFAVALVDEAETPSTLDAVLPSPTRSKSAGKPIPRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZW6</accession>
    <name>A0A2Z5QZW6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-6-phosphate 1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88045">
        <property type="protein sequence ID" value="BAV88045"/>
        <property type="gene ID" value="RA11412_1746"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1746"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="2">
        <location>
            <begin position="28"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="190" mass="21612" checksum="073CD1FA5785E05B" modified="2018-10-10" version="1">MTIGHESNPLRDSRDRRLARIAGPSALVFFGVTGDLARKKLLPAVYDLMNRGLLPPSFGLVGYGRREWSDDDFRAYVRESVQAHARTSFREDVWNQFQKGMRFVQGAFDDDAAYERLKGTLAELDERGAQGNHAFYLSIPRRLSSRCCRSLPSMGWPAVRKMRAQRMLALGGGVWWWRSRSGMTLSRPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R001</accession>
    <name>A0A2Z5R001_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00950</name>
        <name evidence="2" type="ORF">RA11412_1786</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88085">
        <property type="protein sequence ID" value="BAV88085"/>
        <property type="gene ID" value="RA11412_1786"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1786"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="420" mass="46246" checksum="4347A082B48AEE30" modified="2018-10-10" version="1">MVDYILGDRGSVEIVTDGYYEAETLQVFEELHIDRERIWFGEAHLVPEPDNPYEPKSIAVYIDELKVGRMSVKDSAAYWEPITRVVASGYVPVVHLQLSAIARRVGEGTRIESYGVLSLSAPGSLFPINQAPARAALLPQGQSMKVLDEKDHSEYLHSILPPNGEGRVILTLEANQMKLSDGRLIDTVEVLHDRKLVGRLSTQMSAQLAPVVKYAYDRNRLTSAWGTIRGNSLELSLTVQALRASEIPAEWYRTLPNNVPELLPEGVAYEVPDAYVATEGENNRSAIEESTTKKRRGFMSALTGGGAPAETAAPETLRAEGLQEDSTEAVVRGERRRLLTLMSVTGLAALLIGLIVAFSYLVVGFIIMALGAVLVLATLYVGRQMAVSPSVIRYADYEAQKEAQQQQQEKPEKPLNTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R012</accession>
    <name>A0A2Z5R012_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transaldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88047">
        <property type="protein sequence ID" value="BAV88047"/>
        <property type="gene ID" value="RA11412_1748"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1748"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="62" mass="6601" checksum="81D0F67686A26669" modified="2018-10-10" version="1">MSESTQKLSDAGVSIWLDDLSRERLTSGNLVELIKSKNVVGVTTNPTIFAGALSKGPRTPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R020</accession>
    <name>A0A2Z5R020_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exonuclease SbcC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">SMC family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_02000</name>
        <name evidence="4" type="ORF">RA11412_1515</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87814">
        <property type="protein sequence ID" value="BAV87814"/>
        <property type="gene ID" value="RA11412_1515"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1515"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="3">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="824"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="301"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="505"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="664"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="1071" mass="117252" checksum="BF4D16A09005A9A8" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R048</accession>
    <name>A0A2Z5R048_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RA11412_1789</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88088">
        <property type="protein sequence ID" value="BAV88088"/>
        <property type="gene ID" value="RA11412_1789"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1789"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="12">
        <location>
            <begin position="86"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="11">
        <location>
            <begin position="243"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV88088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="583" mass="66519" checksum="5EB20939399C792A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R060</accession>
    <name>A0A2Z5R060_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87926">
        <property type="protein sequence ID" value="BAV87926"/>
        <property type="gene ID" value="RA11412_1627"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1627"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="105" mass="11699" checksum="7C272D708027366B" modified="2018-10-10" version="1">MKADGEVVHELQAKQLALDTYFITDFRIPTAWKPGQEHTITVEPATEPRRSVSVTVRVAEHPREQTVHECVACEQPDTHPTVTPFAGYPAAGGHRENPRVQVCDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R062</accession>
    <name>A0A2Z5R062_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Rieske iron-sulfur protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">aioB</name>
        <name evidence="18" type="ORF">I6I94_00865</name>
        <name evidence="19" type="ORF">NCTC10207_01134</name>
        <name evidence="17" type="ORF">RA11412_1808</name>
    </gene>
    <organism evidence="17 20">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 20">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="18 22" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 22">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887145.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88107">
        <property type="protein sequence ID" value="BAV88107"/>
        <property type="gene ID" value="RA11412_1808"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1808"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045603">
        <property type="entry name" value="QcrA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19297">
        <property type="entry name" value="QcrA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="16">
        <location>
            <begin position="245"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="BAV88107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QQT89222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VEI23037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="369" mass="41022" checksum="473714802CF63246" modified="2018-10-10" version="1">MGNHSDGTKAQGSAVVTSSEESEEQFRNPGLPPHRPRLTDVDPKRAKGAERQVILLFVLSMLGSLLFWVAYFGISAEGNFYDVNNTEPTSKLQLQNLLLGLGIAFAMFGIGIGVVHWARTLMPDHELVEERHDLRPEEDRAEATEIVETIVDESGIKRRPLLRNTLIGSVILAPLTFVTFFRDLGPADPSVLKRTMWDKGVRLVRDPSGTPIKAADVTIGSAYHVLPETLSSLSHENGYLEEKAKAVVLLMRLDPQEMKISEERKNWHVDGIVAYSKVCTHVGCPIALYEQRTHHLLCPCHQSTFDAADECKVVFGPAGHALPQLPITVDSNGYLVAQSDFHEPVGPAYWERGAQIEQMRTEREKEGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R071</accession>
    <name>A0A2Z5R071_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Malonyl CoA-acyl carrier protein transacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87920">
        <property type="protein sequence ID" value="BAV87920"/>
        <property type="gene ID" value="RA11412_1621"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1621"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="118" mass="12453" checksum="DB73ED8A2BB50E9B" modified="2018-10-10" version="1">MIPLKVAGAFHTQAMAPAVEPLAAFAAELTVNDPAYELLSNRDGERISTGREFVDSLVSQVTSPVRWDRCMSTLMAAEVDSIIEVAPAGTLVGLAKRAMRGVPSAAVNTPEDLEAVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0C8</accession>
    <name>A0A2Z5R0C8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00595</name>
        <name evidence="2" type="ORF">RA11412_1878</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88177">
        <property type="protein sequence ID" value="BAV88177"/>
        <property type="gene ID" value="RA11412_1878"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1878"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="181" mass="19836" checksum="950D896A4CB9B0B7" modified="2018-10-10" version="1">MEKLIPTLICVAVVALCFFGIWRGWKSRLKRQSTMFGSLKDVPERYDGLEADAAFEGEYVSTTMFGDALNRVGFDQLGFKTKSTLLIYSDGIIFTRNGAKDLWIPAKKLAVITTGQGIAGKVVERDGLLLIGWTLDGHRVQTGFRTRYASQKAEALARLRGIAPEAVDTLAGWSAAKDSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0K6</accession>
    <name>A0A2Z5R0K6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">ATPase component BioM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_01015</name>
        <name evidence="5" type="ORF">RA11412_1771</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88070">
        <property type="protein sequence ID" value="BAV88070"/>
        <property type="gene ID" value="RA11412_1771"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1771"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="272" mass="29917" checksum="38FF8D6B956D4579" modified="2018-10-10" version="1">MFFSRRRVAETSQEAADTPCYLRTHQVTVTVDLPDGGNQRILDSVTVRLEAPRTAVLGLNGSGKSTFLGLFNGLVHPSEGTVEVNGVDALAHPHKARQQVGMIFSDPAAQLIMPTVREDIELSLRRNPTLTRKQRLHKAHELLAQRGIEDKQDQSVFSLSGGEKQLVALTSVLATDPRVLLLDEPTTLLDLRNRLNLMRHFNTLNQMLVISTHDLDLAAAACDEAIILHEGRLMAHGAAADTVRTYRNWCSHGFPHEHTRGGAADTLGSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0P1</accession>
    <name>A0A2Z5R0P1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">trpD</name>
        <name evidence="7" type="ORF">I6I94_00850</name>
        <name evidence="6" type="ORF">RA11412_1811</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88110">
        <property type="protein sequence ID" value="BAV88110"/>
        <property type="gene ID" value="RA11412_1811"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1811"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="81"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="98"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="116"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="358" mass="37903" checksum="283567C087A8F378" modified="2018-10-10" version="1">MKATVSEPLSWKQILNQLIKNIDLTVDQIDWAMNQIMTGATPEPVLASFLTALHMKGETPAELGALARGMLAKAEKVNIGPDAVDIVGTGGDQQNTVNISTMAALVIAGTGATVVKHGNRASTSKSGSADVLEALGIRLDMPIESVAECAQKTGITFLFAMTFHPAMRFVGPTRRALGIPTAFNYLGPMTNPARVRSSAIGVAHQEMAPKIAQVFADRGDHAIIFRGNDGLDELSIATSSQLWEASAGELKEYTFTPSDYGVRHAPLEALRGGDAQYNATIFRAILAGEGGNGGELGPIRDAVLINAAAGLTAYRDSDEGAFDERYTQALADVRESIDSGAADSVLNRWIDFSRAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0P3</accession>
    <name>A0A2Z5R0P3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88308">
        <property type="protein sequence ID" value="BAV88308"/>
        <property type="gene ID" value="RA11412_2009"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2009"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025327">
        <property type="entry name" value="DUF4233"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14017">
        <property type="entry name" value="DUF4233"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="178" mass="19855" checksum="580AB058288A55EC" modified="2018-10-10" version="1">MNLKVTKRSSDTLTGPESLNRRAVAQNNPEKKQFLTRAQRDWKPGMKKKSRSVKVMFASTILVLEAFVAFFGTLAVFGHHFSDPVEIKILIWAVGLAVAAVLMLLPAQLKSSWGYTAGWVLQVALLALSALTLPLTLIVVVGFVGCWWYGLRAGTRLDAENKAREAEQAEWERQHPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0T3</accession>
    <name>A0A2Z5R0T3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88091">
        <property type="protein sequence ID" value="BAV88091"/>
        <property type="gene ID" value="RA11412_1792"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1792"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="108" mass="11571" checksum="985FF91076E9C4F5" modified="2018-10-10" version="1">MVGGFGILMDGVQQLYELFFTPGDGFGDVVFEVRVPAVFVYGALGDVVLRCCFTVFCFGGECGEEFASGVCCFCAADCVLRLGCGLLFIVLRYRMIPPAGWAGGVRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0W9</accession>
    <name>A0A2Z5R0W9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-L-isoaspartate methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88146">
        <property type="protein sequence ID" value="BAV88146"/>
        <property type="gene ID" value="RA11412_1847"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1847"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="121" mass="13480" checksum="B3184F329174A8E5" modified="2018-10-10" version="1">MEGLRLDGRFTEPECDETMVRGWHVEGLAVRPDHRMVAHTAFLVVARRLADGSARLAPKRRASKSDFSDADMDAWIPMNVGEREVTDKKVRRAVRDAKNLAQNAAAAHQIAVEESRQGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0X1</accession>
    <name>A0A2Z5R0X1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent DNA helicase RecG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88387">
        <property type="protein sequence ID" value="BAV88387"/>
        <property type="gene ID" value="RA11412_2088"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2088"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="111"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="352" mass="38116" checksum="E13BF9D4906A25F7" modified="2018-10-10" version="1">MIGTHALLSEGVEFNDLGLVVVDEQHRFGVEQRDGLRGPHGELPHRLVMTATPIPRTVAMTVFGDLDVSVLDQLPAGRQKISTHVVPLAEKPGWASRLWSRAREEIDAGHQVYVVVPKIGEDGDDTEEGVQLFGDGGREEAKSSDGKIRLTSVTAMNAYLQDVPALSGVRIGTLHGRMDAAEKTRVMTAFERAEIDLLISTTVIEVGVNVPNATLMIIMDADRFGISGLHQLRGRVGRGGAAGTCLLVTRQEADGISRERLDAVAGTTDGFELSRIDLQQRREGDILGAAQSGRKSTLKFLRALTDAKIIERAREDARGIVADDPTLAKHPNLARTIDRALDADREAFLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Z8</accession>
    <name>A0A2Z5R0Z8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">carA</name>
        <name evidence="5" type="ORF">I6I94_00600</name>
        <name evidence="4" type="ORF">RA11412_1877</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88176">
        <property type="protein sequence ID" value="BAV88176"/>
        <property type="gene ID" value="RA11412_1877"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1877"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="13"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="397" mass="42969" checksum="4B35525A1CC62705" modified="2018-10-10" version="1">MTVSTRSGALRTDRALLVLEDGTIYRGYGYGATGASLGEAVFSTGMTGYQETLTDPSYAGQIVAQTAPHIGNTGVNTTDAESRKIWVAGYVVRDAARVASNWRSERTLEEELIEQGIVGIQGIDTRALTRRLRSHGSMRAGVFSGRQANRPDEELLSEVRASEPMAGRKLADSVTIDKAYTIEPHEHGWFAPPIASIVALDLGIKAMTPQRFAERGVRVHVLPANATLNDIYAHNPQGVFFSNGPGDPATADEQVELLREVLRKGTPFFGICFGNQLLGRALGFGTYKLPFGHRGINQPVMDKTTGKVEITAQNHGFAVDAPLDGPVQAPVEEFGRVEVSHVGLNDNVVEGIRCLDIPAFSVQYHPEAAAGPHDAAYLFDRFIELMTATEHQTAKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R103</accession>
    <name>A0A2Z5R103_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88220">
        <property type="protein sequence ID" value="BAV88220"/>
        <property type="gene ID" value="RA11412_1921"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1921"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="180" mass="19668" checksum="93BDD418743CF462" modified="2018-10-10" version="1">MSPRIPTGKRPQITRTITSFTIVACLLATAGCAEYVDEETDASGTISTSASHTPSASASAKSSVPLTKERPAPTLPDGSPAPLSSTELDNYYAGKFIPPTDKHPVYNMGAPVLSDTVKSRELDGVDALIKYMGETYRYTAYTNTEIENYTKNVYAPDYQYDKSSEKTNVPTKPRRSEQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R128</accession>
    <name>A0A2Z5R128_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical radical SAM family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88250">
        <property type="protein sequence ID" value="BAV88250"/>
        <property type="gene ID" value="RA11412_1951"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1951"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="140" mass="15955" checksum="688EA9DA1E658D29" modified="2018-10-10" version="1">MKAAISYRPDHISAYSLIVEDGTKLAAQIRRGDYTMPDNDLMADMYLLAEEYLTDAGYSWYEVSNYSSSAQTRSDHNLAYWRNQDWWGIGPGPIRTLTVPGGGTLNTLFLMRTVYGPGSPRQLRVRFWMPPPGRLRRLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R142</accession>
    <name>A0A2Z5R142_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR repeat</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_10655</name>
        <name evidence="2" type="ORF">RA11412_2206</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037235079.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88505">
        <property type="protein sequence ID" value="BAV88505"/>
        <property type="gene ID" value="RA11412_2206"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2206"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="349" mass="38833" checksum="D21F876F66129FEA" modified="2018-10-10" version="1">MTEPNKPLDQMTAQERLDLGVECLDAGRLNDAVHILATVSAGENPGAYSWAQYFLGDVYEDAENLREAITAYNNVHRHDNPVAYASAQNSIGILYKNMGRLDDAVAAFSRVVREDNPESYAWAQNNLGTVYQTMRRLDDAATAFRNVQLSNSPEAYTNAQFNLGNTYKLMGKTDDALQSWGGVLREVDAETYAQAQFNIGSTCKNQGRIDEAIAAWGRVRHDDNPSVYARAQLSLGLTYAPLGQLDEAIAVWRNVRREDNPEAYAAAQNNLGSAYEDKELYDDSFAARNRVLRSDSPYIYAVAQLNMGIAHYNNGSLDEAVTAWNRVLEEDDPQSYAEAQRNLALVNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R151</accession>
    <name>A0A2Z5R151_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome d ubiquinol oxidase subunit I</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Cytochrome ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I6I94_10605</name>
        <name evidence="13" type="ORF">RA11412_2216</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88515">
        <property type="protein sequence ID" value="BAV88515"/>
        <property type="gene ID" value="RA11412_2216"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2216"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV88515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT88948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="524" mass="57968" checksum="E650ED54F0D7EE28" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R158</accession>
    <name>A0A2Z5R158_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88383">
        <property type="protein sequence ID" value="BAV88383"/>
        <property type="gene ID" value="RA11412_2084"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2084"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="174" mass="18726" checksum="5B566F96346D3DF6" modified="2018-10-10" version="1">MLSVTNLMHRPGTSETFAEVVPAPADLGNALIGVPEGTDIDMNVRLESVVDGILVTGDAVVDVHGECSLCLDPIDYEMSADIQELFVFEKAPEGGPEDEVDEQYAVEGETLDLEPALRDAVILQLPFQPVCRETCQGLCSECGARLEENPGHHHEALDPRWSALQGLLGTGTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R167</accession>
    <name>A0A2Z5R167_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88393">
        <property type="protein sequence ID" value="BAV88393"/>
        <property type="gene ID" value="RA11412_2094"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2094"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="589" mass="59027" checksum="684D9D88F68B18F5" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R184</accession>
    <name>A0A2Z5R184_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88438">
        <property type="protein sequence ID" value="BAV88438"/>
        <property type="gene ID" value="RA11412_2139"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2139"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="382" mass="42707" checksum="2865B00569ED469B" modified="2018-10-10" version="1">MSTTEPAPASTPDTTPWLPLSVNARGIYLAAAIDPTNPCYNTAELLECPVGTNRDTLRQALRHLYEENEGFRVRTRLHAGRAEQQVLGLDKFLENIEFLENIELLPVPENPHEEEPDSEPVPAMVRAWASSLIAEPLNPDAGITVRSRVAFYADRLWVYHSFHHVVADGFAAFNGLSRIASIYRALSSGHPVPPVSRASLAELIAADNAAEPARASDYEYWTAGEGATALEQPDTSLAARTAAPAPARYGPHCLSRARYSRTCWRRPKIWGVLAGRRNRSHRRVPGAYWRVRYGRVRHPPNEPHVRPHPARTNPSPRQNQCKHRNHRRERAARAGAFPWAHRSGPELRQRPIRPQHPAPPGTSRRLGTGRSTQRLPPLWGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1C3</accession>
    <name>A0A2Z5R1C3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_2154</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88453">
        <property type="protein sequence ID" value="BAV88453"/>
        <property type="gene ID" value="RA11412_2154"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2154"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="8">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="9">
        <location>
            <begin position="176"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="283" mass="29786" checksum="0D6C748CA0C66986" modified="2018-10-10" version="1">MVGVLTREDAPVGRKRILSASAVAQRAEQLGIPVIKASQWSAQTAHAIASLGADAAAVVAYGALLPQEALKLLPHGWVNLHFSALPAYRGAAPVQRALMAGETTIYSNTFLIEEGLDTGSVFERDSTPVGDEDTAGSILNRLAETGGELLLRTFARIAEGQTGTPQTGQASYAHKMSIADGRLDFNEPAERVLATFRGVTPEPGAWCELAGNRFKIAALQRGSHETELAPGQIQLRGKKVYVGTGAGELQLVRVQPAGKKVMDAPAWARGVGSDLAEGKVVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1H9</accession>
    <name>A0A2Z5R1H9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transport ATP-binding protein CydCD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_2214</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88513">
        <property type="protein sequence ID" value="BAV88513"/>
        <property type="gene ID" value="RA11412_2214"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2214"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034775">
        <property type="term" value="P:glutathione transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014223">
        <property type="entry name" value="ABC_CydC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02868">
        <property type="entry name" value="CydC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="735"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="273"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="596"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="922"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="313"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="956"/>
            <end position="963"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="1133" mass="118123" checksum="9FE8DB2E522E9F5D" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1N1</accession>
    <name>A0A2Z5R1N1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6318 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_10350</name>
        <name evidence="4" type="ORF">RA11412_2274</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88573">
        <property type="protein sequence ID" value="BAV88573"/>
        <property type="gene ID" value="RA11412_2274"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2274"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046281">
        <property type="entry name" value="DUF6318"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19843">
        <property type="entry name" value="DUF6318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340102" description="DUF6318 domain-containing protein" evidence="2">
        <location>
            <begin position="39"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6318" evidence="3">
        <location>
            <begin position="93"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="257" mass="27989" checksum="5B71EC2F5896140B" modified="2018-10-10" version="1">MNYMPMPDPSMLTRRRALLLAGTGLGAVAFTACGGAGNAEGQPASPSETGSSTPQTSSPEASASGISDTSATPTPVGETFSKGFSGGSQAPEGEYRPADDKGPAQNVPKPQEPEGMNLETPEAFFKFIEYWNEQRNYALQTGDVKGYAHITSGAFTKELQAIAYMETLYKKGGWVIGGLRKIIYEKDSFEHVSGKDYQYSLLGRTVVSPAITFDNEKRTIRTEDFTESNKYSVEFKIVYNGREWLVRGVTNVAKFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1S0</accession>
    <name>A0A2Z5R1S0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted O-linked N-acetylglucosamine transferase, SPINDLY family</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">TPR repeat</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_10630</name>
        <name evidence="3" type="ORF">NCTC10207_01473</name>
        <name evidence="1" type="ORF">RA11412_2211</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887392.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88510">
        <property type="protein sequence ID" value="BAV88510"/>
        <property type="gene ID" value="RA11412_2211"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2211"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI23366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="201" mass="22061" checksum="869A6AFABA20AAAF" modified="2018-10-10" version="1">MAEQPDAGTQRYAQEQVNLGAEHYRQGRFAEAAAAWGAVPESVPDQYAVAQVDLGIMYGSTGDAAQAIAAWQKVPQSEIQAYAVAQYNIGSVYEGQEKDEAALAAYGNIPEADTMHYAMGQFNSAVLLHMHGNFRAALGVYQNVPESVPDQYARAQLNLGVLYQQMGLDDKARESWNRVPADYPDLYEVAQSYLNDEDEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1S4</accession>
    <name>A0A2Z5R1S4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86819">
        <property type="protein sequence ID" value="BAV86819"/>
        <property type="gene ID" value="RA11412_0520"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0520"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="134"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="242" mass="26081" checksum="6283A3822D957B12" modified="2018-10-10" version="1">MLGRSSELVLRERISHLTDTRNDALDFQQDEISRIERDLHDGVQAHLVSMGMTLNEVAALMQEDPERAQQMLSQAQNSSVTALQELRGLVRGIRPPLLADRGLNEAVRSLCTSTSVPTTFTSTLTGRLPEPLETALYFAAAELVTNAVKHANAQKITVGITQGESLIMLEVQDDGTGGIPQDALGSKASGGLEGIRRRLATFDGEMFVSSPAEGPTSVRAIVPYAAPHPSSTNLPSREVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1S8</accession>
    <name>A0A2Z5R1S8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trk system potassium uptake protein TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_2185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88484">
        <property type="protein sequence ID" value="BAV88484"/>
        <property type="gene ID" value="RA11412_2185"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2185"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0630">Potassium</keyword>
    <keyword evidence="1" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="121" mass="13043" checksum="5256218BDC38E9B7" modified="2018-10-10" version="1">MKVLIVGAGSVGASIARELHASGHEITIIDSKPETKKRANLPQVQWFIGDACELSVLKLAVPEESEVVVAATGDDKANLMVSLLCRSEYGVPRTVARVNNPAMSGFLTSRGVWMWRSPPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1X7</accession>
    <name>A0A2Z5R1X7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative two-component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_2458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88757">
        <property type="protein sequence ID" value="BAV88757"/>
        <property type="gene ID" value="RA11412_2458"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2458"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="236"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="454" mass="49129" checksum="2D9627F9A8B82C4B" modified="2018-10-10" version="1">MTITRTPDHDSKPAASNPHRTATPTRGKASFFDKSGIVRSLVWGSCLNISSSGFMLIAISNTGEAEFVKNNLFLCTLLYQICIVLFFAANTMPQLIPVKNTVLRTALWCVLVTVPIGYVIALYPQGIAGMLYTISPLWVALWLMNLHIPFKLGVKTAVAIAVVFTTNYFVGVVGQGYFDNAPTAPFPVVSGDKTLNGFFIFDIVTTIHIIAYFVGRSMHKSREHKAIEKELDILTERERIARDVHDVLGHSLTIVNLKAELAAKLVETNAPAAQEQMRQVAQLSRQALAEVHSTVTRLRVPDLEGEVLASSRALETAGIQANLPDATTAANIAGMNSALFSWALRETVTNIVRHSHATYATVRLNPTGLEVIDNGIGIGDAPCKSGLIGLRTRIEDAGGTLTLGNAPKHWLQQAPVAGVGMGAESASAWTRKPTRLWGSRAAENTSCRRSADDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Y9</accession>
    <name>A0A2Z5R1Y9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88703">
        <property type="protein sequence ID" value="BAV88703"/>
        <property type="gene ID" value="RA11412_2404"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2404"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="62" mass="6190" checksum="7E33399C503881B4" modified="2018-10-10" version="1">MAAPAGVAQIILSAPAPFSCGGAGPFNADYQAVRAVTFSNKARTAFLYSRAKAIGKSGGGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R204</accession>
    <name>A0A2Z5R204_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TPR repeat</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_10650</name>
        <name evidence="1" type="ORF">RA11412_2207</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88506">
        <property type="protein sequence ID" value="BAV88506"/>
        <property type="gene ID" value="RA11412_2207"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2207"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="241" mass="27245" checksum="0A84ACD7C3DCE932" modified="2018-10-10" version="1">MTEPNKPLEQTTAQERLDLGISYFKEGKLDEAITVLKTISTSEDPTIYALSQRLLGDIYGCMGKLNEATAAWSKVRCEDNPETYAWAQFSLGNTYKIIGKLGEDIAAWSNIRREHSCEAYAVAQYSLGNTHKTMDQLDDAIAAWSNIRRDDDPEAYAWAQLSLGDAYRTMDQSDNAIAAWSSIRRDDDPNAYAWAQSRLGFAYQTQNKLDEAITAWSNIRREDEPELYAEAQRNLALVNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R220</accession>
    <name>A0A2Z5R220_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88795">
        <property type="protein sequence ID" value="BAV88795"/>
        <property type="gene ID" value="RA11412_2496"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2496"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="126" mass="14246" checksum="5E996C252B8004DB" modified="2018-10-10" version="1">MDASLLSELVVQIFRMNGALTTWGDRFAAESGLTTARWQVLGAISMAKEPSTSPQIAERMGITRQGVQKQLNLLRDEGLVMPIENPAHKRSPRYSLTEHGERKLAEIRKRWRQQVEQWSGGISMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R250</accession>
    <name>A0A2Z5R250_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplQ</name>
        <name evidence="6" type="ORF">RA11412_2538</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88837">
        <property type="protein sequence ID" value="BAV88837"/>
        <property type="gene ID" value="RA11412_2538"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2538"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="170" mass="18896" checksum="6F32E819D7F20F9B" modified="2018-10-10" version="1">MPTPTKGPRLGGSPTHERLMLNNLSAQLFQHKRITTTLTKAKRMRPVAERFITFGKKGDLAARRRVLRSITDKSVVHELFTVIAPAMAERPGGYTRIIKIGNRKGDNAPMAVIELVMEPVATKGAVAEATKVAERLLMLPRLRRLRQSLLLRKQGSLLTCPRVLTPAGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R295</accession>
    <name>A0A2Z5R295_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88596">
        <property type="protein sequence ID" value="BAV88596"/>
        <property type="gene ID" value="RA11412_2297"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2297"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045596">
        <property type="entry name" value="DUF6459"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20060">
        <property type="entry name" value="DUF6459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="189" mass="21255" checksum="7D299A8A17DB6B0B" modified="2018-10-10" version="1">MHAAKKIDAEHNPLIPADHHATASTHTNLRYAPSGFTLLPITDYAQEIMGTPDANRPARVKIRKPRRTGRPLKRSDSAARSVEILCSGLCLGIVEMLAGHRTLEQFRKWFSPSCCAELQALGQTIRSQRSQTRRTATPRVLRSRAQKVDNAKGGYEVTLVVHDGVKVRAMAMRVIERYSTWHITTVEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2B3</accession>
    <name>A0A2Z5R2B3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PadR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_09705</name>
        <name evidence="3" type="ORF">RA11412_2433</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_039954902.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88732">
        <property type="protein sequence ID" value="BAV88732"/>
        <property type="gene ID" value="RA11412_2433"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2433"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="93"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="179" mass="20472" checksum="FE3E45D4EB787F9E" modified="2018-10-10" version="1">MELKHAILGLLSIQPMSGYDLNRAFNNTVAHFWYADQSQIYRTLDKLTANKAITTKVIHQEGKPNRKVHSLTAIGRAELEDWLTSPLEQERYKEPFMARLFFAANLTHTEVVQLLAEREKQIERKLQSLKTIDAPAEDLASALRAATLRKGIVETEAELAWIQQTRESITRFSPPSKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2C2</accession>
    <name>A0A2Z5R2C2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Nudix hydrolase family protein PA3470</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_09835</name>
        <name evidence="3" type="ORF">RA11412_2401</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88700">
        <property type="protein sequence ID" value="BAV88700"/>
        <property type="gene ID" value="RA11412_2401"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2401"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="159" mass="17351" checksum="573313620E425E5C" modified="2018-10-10" version="1">MPENPRPQAAHTHAAIDTERKIVYVSAVAIRNERGLVLTVRKTGASGYMMPGGKPDPGETPLGAAVREVTEELGFAPDPARMVHLGTFQAPALNENGYTVRAETYEYLPHPSEYEVLAALTPQAEIAELRWVDPAQNRDATQAPLNIECIFPVLSAHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2C3</accession>
    <name>A0A2Z5R2C3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="1">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88907">
        <property type="protein sequence ID" value="BAV88907"/>
        <property type="gene ID" value="RA11412_2608"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2608"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="1" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoeA_N" evidence="2">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="177" mass="18719" checksum="62ACE2E9FEC2EB42" modified="2018-10-10" version="1">MPHHHPPAVAWEQARKNLHAAGLTCTAGTDVETLPPKAAIGRYTADDVYSLMDVPHYDSSAMDGYAVSGTPPWLLVTPEYPDDERVNIHRLTVAIEPGQATPILTGGLLPRGAQAIVREEHTTLNTVGGITTVTMASGHIPRPMAPISAAPGPSCPQAGCWLSAARSLPPALPHFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2E1</accession>
    <name>A0A2Z5R2E1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88710">
        <property type="protein sequence ID" value="BAV88710"/>
        <property type="gene ID" value="RA11412_2411"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2411"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="60" mass="6005" checksum="F399B72F9723355E" modified="2018-10-10" version="1">MLGVILAGFGLVLLLGEALSVSGAVAVAEADALAPARGFTDVPLLHPARAAVARAQRIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2E5</accession>
    <name>A0A2Z5R2E5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88646">
        <property type="protein sequence ID" value="BAV88646"/>
        <property type="gene ID" value="RA11412_2347"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2347"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="40" mass="4503" checksum="3254E15805FF7C19" modified="2018-10-10" version="1">MLAQATGRIREIEQQMVGGLSDTQRQELWDLLTACIEGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2I2</accession>
    <name>A0A2Z5R2I2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88760">
        <property type="protein sequence ID" value="BAV88760"/>
        <property type="gene ID" value="RA11412_2461"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2461"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="265" mass="27426" checksum="65FC8252FA03D893" modified="2018-10-10" version="1">MGAPSTGGTAKNPKTPETLENPEQPERTKPLPGAGEVVPSGTDTSAAEPDGNTPETGTSLDTGGTETRDNTPKSADPQHTDPQPADSPSEEPQSAQLQPDTDQAMAETTRPLPDTAAPESDSSDTTAALDTPDEEEPTVALDEEAAFSHTKTLGHAVAGRYVSEDDLDGMGIPAEHPMRAPSVLLAPPAQPFAAGLRRTLAILLAALALITAVLGAGGKWAGTHLISTRGFNDLSSRLADDQDLQKRVAQAAVTDLMNSEGLKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2K5</accession>
    <name>A0A2Z5R2K5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87129">
        <property type="protein sequence ID" value="BAV87129"/>
        <property type="gene ID" value="RA11412_0830"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0830"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="244" mass="27244" checksum="B9AA00B3F9657A4B" modified="2018-10-10" version="1">MNPKRIEDAKVRKAIFLGIDRKALSNIAFQNLPYEEDPSGSMLHLPFEEYYEDNFPKADGDAKSAAQKLLEEAGYTKDGEYYAKGGKQLRYKITVFGDDPSKSSMARSFAQTMKEIGINFEVETRGSAEFSKVTGSKEYDIIVSGFSLSGADGTAATKQFYYSKENDGVGNAEIDAMIEKMAVIKDDAERNKMCNQIEKKHMAEVSTIGTVFNGPDLMVCKKELANYGPTLFKPIEWEKVGWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2L0</accession>
    <name>A0A2Z5R2L0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88995">
        <property type="protein sequence ID" value="BAV88995"/>
        <property type="gene ID" value="RA11412_2696"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2696"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="4307" checksum="ABFE52BCEBEDD043" modified="2018-10-10" version="1">MQHKTAQAEAACGAPLLDAPQAPKTVVVAGTGPARSPQSSHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R327</accession>
    <name>A0A2Z5R327_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">htpX</name>
        <name evidence="15" type="ORF">I6I94_08670</name>
        <name evidence="16" type="ORF">NCTC10207_01871</name>
        <name evidence="14" type="ORF">RA11412_2671</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="15 19" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 19">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023133154.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88970">
        <property type="protein sequence ID" value="BAV88970"/>
        <property type="gene ID" value="RA11412_2671"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2671"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="77"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV88970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QQT88591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VEI24031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="296" mass="32125" checksum="1E43515C2E457FCE" modified="2018-10-10" version="1">MHKHYNGLKTALLMGTMVGLLMLIGAVISAYTRSMLFIWLFGLIGLGSVAYTYWNSDKLALRSMNAYPVSREEVPVLYDIVEELSSRANQPMPRLYVAPTQTPNAFATGRNPQNAAVCCTEGILQLLDEREMRGVLGHELMHVYNRDILTSSIAAGISTIIGTIANVVSFGAMFGGGNRHERGNPLGALAIAVLAPLASAVIQMAISRTREYDADEDGAALTNDPLALASALNKLESGVSLYPMDPDNPRTATTSSMMIANPFGNLNIGKFFSTHPPMDQRIARLQQMARDNGQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R357</accession>
    <name>A0A2Z5R357_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">6-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_2627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88926">
        <property type="protein sequence ID" value="BAV88926"/>
        <property type="gene ID" value="RA11412_2627"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2627"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="8">
        <location>
            <begin position="2"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="297" mass="32267" checksum="4D366D1BC9C978F6" modified="2018-10-10" version="1">MKIGLLTSGGDCPGLNAVIRGAVLNGVKKYGYEFVGFRDGWRGVVDGDFMDLPRTKVRGLASQGGTIIGTSRTNPFDGPNGGPENIEIMMERHGIDAIVAIGGEGTLAGAKRLADAGLPVIGVPKTIDNDLRATDYTFGFDTAVSIATEAMDRIRTTGESHHRCMVAEVMGRHVGWIALNSGMASGAHAILIPEVKVSMDEVCQWVKEVHDRGRSPWWWLRKGSSPKALTRSWRIRVPKKTGGPAWVVSVNTLPTRLRPAPVLKPATPSWGIFSAVAHQPVLTGCWQPAWVWARWIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R362</accession>
    <name>A0A2Z5R362_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FemAB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87369">
        <property type="protein sequence ID" value="BAV87369"/>
        <property type="gene ID" value="RA11412_1070"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1070"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02388">
        <property type="entry name" value="FemAB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="343" mass="38028" checksum="54C63882FE69A483" modified="2018-10-10" version="1">MVPMSNILQSEIWARFQESNGHTVIRRSGEGWSYIATVEGGKTGRYLYSPYGPVAEDAQTFDAALTSLKAEAKAHKCLFVRIEPTNPAIWGERDAAAFLTSRQAVLSPRQVQPAHTQIIDLSGSDDEILKGMKSNNRNLHRNIHKKGVSIEVSEDPEDMTVLYQFLEATADRNGFNRQRDEYLSQVARVLMPAKAASLYIARLTHEDGTVEPIAAAFVYDSDDTRTYAHAAASFEHRKLSAGIPVVTNLILDAKAKGLKYVDLFGIAPEDEPNHEWAGFTKFKKSFGGESVTYPGTWDVPVNAAGYKVYDAAYRARPKAQQALAQAKELVKDAPARLKKLLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R364</accession>
    <name>A0A2Z5R364_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H oxidoreductase YRKL</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NAD(P)H-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08450</name>
        <name evidence="2" type="ORF">RA11412_2731</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89030">
        <property type="protein sequence ID" value="BAV89030"/>
        <property type="gene ID" value="RA11412_2731"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2731"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="182" mass="20694" checksum="40856BD9FF9135BB" modified="2018-10-10" version="1">MKTLVIVTHPNIHESTVNKTWVQMLRQHPDRFTVHELYSEYPDGVIDVEREQALVEEHQNIVLQFPVYWFNCPPLLKQWCDEVLTYGWAYGSKGKAFENKKLGIAVSLGAPASEYSAEGSVGYTVAETLRPFELTANYISANYQPLFTFHTIDTYESYDEAAAQLVADSAGDYLAHLNTYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3A9</accession>
    <name>A0A2Z5R3A9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane component YkoC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_2737</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89036">
        <property type="protein sequence ID" value="BAV89036"/>
        <property type="gene ID" value="RA11412_2737"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2737"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV89036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="206" mass="22323" checksum="FD361C0038ECDC8B" modified="2018-10-10" version="1">MLRKETAHEHGFFGPSAERNSWFGGLNAGVKCVVTVVLILAAILIKDPVSATVMLVLELVGFTVVGFRPVNLLARAWPILVAVASTGWSVAILVNKTGPVILDFGVNSITQGSLAAAVSMMLRSLAMVLPTFAFVLSTDPTDLGIRWRRPSGSRHGLCWPRWRRCAWWESYLGSGIRWGRRGVPAGWARGRARGGGCAPVRGRCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3C8</accession>
    <name>A0A2Z5R3C8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_08215</name>
        <name evidence="3" type="ORF">RA11412_2787</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89086">
        <property type="protein sequence ID" value="BAV89086"/>
        <property type="gene ID" value="RA11412_2787"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2787"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340121" evidence="2">
        <location>
            <begin position="37"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV89086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="189" mass="19641" checksum="6E470631C3C2190F" modified="2018-10-10" version="1">MNTTSTNTRKIATCATIVLAGTLVLSACSGGETIKGTEVSSSSSGTAQATERIRDLGFNTKDATVEDSGAWQTHNGQGMTLKVHSSGAWEVRNSQNTKVLDVKSDGSWSWADGPDGSITVNKDRSWELSGENGNISVAADGSYDSTGKKDDFKGPAKPGTPAKPDNSKAKDPAQPISPVVLGRAKAVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3E9</accession>
    <name>A0A2Z5R3E9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RA11412_1260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87559">
        <property type="protein sequence ID" value="BAV87559"/>
        <property type="gene ID" value="RA11412_1260"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1260"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="10">
        <location>
            <begin position="98"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV87559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="236" mass="24574" checksum="9B0198D2F0803EF4" modified="2018-10-10" version="1">MGSEAVRAVNTAADMDLVAALGSADPLTKLLDVKADVIIDLTVPTATEANVRFAVEHGIHAVVGTTGWDEERLSSLKQLLGEHPGVGVLIAPNFAIGSILATEFAAKAARYFESAEIIEIHHPNKVDAPSGTAAHTARKVAAAREAAGVGASPDATETDPLGSRGAKIDGISVHAVRLRGMVAHQEILLGDTGQLLTIRHDSFDRASFMPGVLLGVREVASHPGLSVGLDNYLELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3J1</accession>
    <name>A0A2Z5R3J1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="13" type="ORF">I6I94_02800</name>
        <name evidence="12" type="ORF">RA11412_1320</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87619">
        <property type="protein sequence ID" value="BAV87619"/>
        <property type="gene ID" value="RA11412_1320"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1320"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="36"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV87619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT89563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="181" mass="19517" checksum="0DE233087750FC68" modified="2018-10-10" version="1">MSVTEPAPMQQIVPDACTTIENYPHEGILFYDVTTLFANAEVFKQCIDELARRFEGTYDVVAGVEARGFLLASALAYATGKGIMTVRKAGKLPRETFREEYSLEYGTAAVEIHCNDFPTGTRVLLLDDILATGGTLVAAAKLVERAQLQVAGIGVLLELDGLGGRTALESYHVESLSAVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4Q0</accession>
    <name>A0A2Z5R4Q0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellulose 1,4-beta-cellobiosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88739">
        <property type="protein sequence ID" value="BAV88739"/>
        <property type="gene ID" value="RA11412_2440"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2440"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016259691" evidence="2">
        <location>
            <begin position="22"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="280" mass="26598" checksum="88EC2D2493AF5B38" modified="2018-10-10" version="1">MSLAVAGMVALSACGSNNSGGTSNAPSSSASSSASTHSSATASGGSGTVNDGGTSGGGTSGGSGAGANGGGTVNSTAGGGAATEQAPAAGSQGDNAAANPNNPNNPNNPNAGAAANGNGGGAQADQGAGANAADNGAAAQQQSGAQQNGANNAQAGANGQADSGARHYNLTPGQYIIHREGSWDYVNTTGLTYHVDGDGSWKSTGEGGTSVVAADGSWTKNYTDGHTVARVEADGTYRVTYDGKLSPEIPINAVPVSPGSLPDPKAVPAVTPVKPTKPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4U9</accession>
    <name>A0A2Z5R4U9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycine cleavage system P-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">gcvP</name>
        <name evidence="10" type="ORF">I6I94_09030</name>
        <name evidence="9" type="ORF">RA11412_2590</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88889">
        <property type="protein sequence ID" value="BAV88889"/>
        <property type="gene ID" value="RA11412_2590"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2590"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT88655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="948" mass="102093" checksum="24B9C89464A251E2" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4Z7</accession>
    <name>A0A2Z5R4Z7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89009">
        <property type="protein sequence ID" value="BAV89009"/>
        <property type="gene ID" value="RA11412_2710"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2710"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="51" mass="5868" checksum="3AE71DE555FAB6EE" modified="2018-10-10" version="1">MNEGAEGTLRQHILEAIHQRVRWRLNPGELVGSTKPRCRRRQPRPVVTPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QV83</accession>
    <name>A0A2Z5QV83_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">23S rRNA methyltransferase rlmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86302">
        <property type="protein sequence ID" value="BAV86302"/>
        <property type="gene ID" value="RA11412_0003"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0003"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="54" mass="5777" checksum="01F097992954AC1E" modified="2018-10-10" version="1">MVVGSEGKGLSRLVTETCDQIVSIPIDSAMESLNAAMAVGITLYDVSRHRTESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVB4</accession>
    <name>A0A2Z5QVB4_9MICC</name>
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    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
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            <taxon>Bacteria</taxon>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="BAV86327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="107" mass="11265" checksum="B03FF4B843986705" modified="2018-10-10" version="1">MLGDSQDAPEIQRPTPDNAAVGEYTMWDERMSVTRIRVAPKETIDYVFEGTSAALVVDGTITITIAGAVTGAGQDYTLGGTESVLHAGDPTPVTITGSGELYIAQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
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    <name>A0A2Z5QVL2_9MICC</name>
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    <reference evidence="1 2" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86435">
        <property type="protein sequence ID" value="BAV86435"/>
        <property type="gene ID" value="RA11412_0136"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4008" checksum="6925B868E78601FF" modified="2018-10-10" version="1">MACEYASGRCARVLDTAEALAQITAGAPGADGAPETGKVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVM8</accession>
    <name>A0A2Z5QVM8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86354">
        <property type="protein sequence ID" value="BAV86354"/>
        <property type="gene ID" value="RA11412_0055"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0055"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="90" mass="8883" checksum="2DE2E4BDF576C02A" modified="2018-10-10" version="1">MCDRALTVMQEYVNTSASSRASQAIQDAQCSWNEQSSSAECTAANGGVKFTAQLSNPASQQQGGGTAPAQPGASPSTAAASESAAGAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVN3</accession>
    <name>A0A2Z5QVN3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86441">
        <property type="protein sequence ID" value="BAV86441"/>
        <property type="gene ID" value="RA11412_0142"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0142"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="125" mass="12902" checksum="183A30EBFC80662B" modified="2018-10-10" version="1">MDVQLAQLNGEPQVWHSQGFDARFNLSELGDTVGYGHTAEQARAVVVEDAALLAEYLGAATAALSEYVAGLSEADLDDVIDTSWTPHVTRGVRLVSMIDDAAQHMGQAAYAAGILAGADGSGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVN9</accession>
    <name>A0A2Z5QVN9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic amino acid transport protein AroP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_0065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86364">
        <property type="protein sequence ID" value="BAV86364"/>
        <property type="gene ID" value="RA11412_0065"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0065"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="232"/>
        </location>
    </feature>
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            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="31"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="486" mass="50879" checksum="0BB529B812D46A73" modified="2018-10-10" version="1">MSTAEQGPVKPADNPATGDGELKRSLSHGQMTMIAMGLALGTGLFLGSGSAIKIAGPGAIIAYAVGSMIAAIIAACAGEMAVRHPVPGGFGTIATRYLSPYAGYIGRWAYWATTVPLTGAELVAVGKYFSYWFPDIPLWVTVAASGILILILNLVSVKSFGALEFFLSSIKVIAVIVFIVLGLLLVFVGLPGHAAAGTANLVNDGGLLPNGVGAVWVSMAIVMFSFGGVEMLSISAAEARNPVRSVRTSVKAMIWRLSSFYVLSMLIILCLMPWQQAAQTGKDIGQSPFVMVFSELGIPYAADITNFVILIAALSGANASLYAATRLLHALAGDKMAPTFAGTTNHNGVPVTALMLSFLGVVVASVMAVAEISNIFELLMALVTLCILVVWIMILLTYQAYKKHQGNSSGFTVWGGRITAGVGLAGVLATLVALFMLPDSSAVVSVQVGVVFFAIISIFYVVLAKKRGGFPRADLEAFTEPQKEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVY0</accession>
    <name>A0A2Z5QVY0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3263 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_07565</name>
        <name evidence="1" type="ORF">RA11412_0155</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023134332.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86454">
        <property type="protein sequence ID" value="BAV86454"/>
        <property type="gene ID" value="RA11412_0155"/>
    </dbReference>
    <dbReference type="GeneID" id="32321896"/>
    <dbReference type="KEGG" id="raj:RA11412_0155"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021678">
        <property type="entry name" value="DUF3263"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11662">
        <property type="entry name" value="DUF3263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="75" mass="8738" checksum="4066A387B50B48CD" modified="2018-10-10" version="1">MVNKKFEELSPLERAIIGIEKRRWKYQGSKEKTIGALGITPIAYYQKLNTMIDDPRVIAAEPILTARLREHRDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW09</accession>
    <name>A0A2Z5QW09_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">RecA-superfamily ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_06920</name>
        <name evidence="3" type="ORF">RA11412_0289</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86588">
        <property type="protein sequence ID" value="BAV86588"/>
        <property type="gene ID" value="RA11412_0289"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0289"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="2">
        <location>
            <begin position="16"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="391" mass="43367" checksum="8232B4B7CBA8DE9B" modified="2018-10-10" version="1">MTLNPFRPGAGHTPPEFAGRQEPLNTFTNILRRTEIGAISRGMMLYGLRGMGKTVLLRRLQEDAKRAGWVTISLESGMGKNAYAQVRTRLGKELALAVRGYRQKSRWKKLLSNVASLSATLGFAGASVVLKADTHHSDTTGLLDFDLPETLLSMARELKDQTPSAGVGIFIDEIQDLDHEMLDILLTTQHEAGQKELPFYIFGAGLPSVPTKLGEIKTYVERLFSYHPLERLNDDQTRLAYADPIAKNGGSITQDALAELVDQSHGYPYFIQQFGRDAWDCASAGNITQDDVRVGVTLGWEELNRGFYMTRWNRATESEKHYLVAVADLMSEKEGDSVPVSEVSSRMKSITTSLSARRASLIEKGVLYSPAYGRIAFTVPGMDRFIKRSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW30</accession>
    <name>A0A2Z5QW30_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipid A export ATP-binding/permease protein MsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_0291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86590">
        <property type="protein sequence ID" value="BAV86590"/>
        <property type="gene ID" value="RA11412_0291"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0291"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="44"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="76"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV86590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="320" mass="34431" checksum="6C5D076DF68C8F81" modified="2018-10-10" version="1">MMTSSCCTLTNVTGAPKNRRYATGTVSILQQIGHLMSTDTAPALTINNLTKTFGTTTANSNISVRLDPGEVTALIGHNGAGKTTFLNQIVGLTKPDAGSISYGGTDLIAHPTQARQICAIMPQVTSSLEGVTPRQAIATAVRIRGLKLGQAKRAVQETLDTLDLGDWADRPGHKLSGGIKRLTSFGMAVTAPAPIYLFDEPTNDVDPVRRELLWRMLRMRAEQGATVLIVTHNLLEVERHADRYLLFNKGLLVRDEPTSALGLEEAKSTLSITATPEFLQELSSVLDVKISPSPGNMPDTEYIEKRAEGDFTIPGSLPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW70</accession>
    <name>A0A2Z5QW70_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86657">
        <property type="protein sequence ID" value="BAV86657"/>
        <property type="gene ID" value="RA11412_0358"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0358"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="4770" checksum="F86FCD56EE6D178E" modified="2018-10-10" version="1">MCLFISWRVLRIIPVRGLLRCGCVRHITTACCIGIGDAGIVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW72</accession>
    <name>A0A2Z5QW72_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86636">
        <property type="protein sequence ID" value="BAV86636"/>
        <property type="gene ID" value="RA11412_0337"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0337"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="38" mass="4035" checksum="142944F7F3890EA5" modified="2018-10-10" version="1">MPAQKAAAQMWAGKPPLTVVKAQYDAEAGYSQLKGNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW73</accession>
    <name>A0A2Z5QW73_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurium resistance protein TerD</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TerD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06760</name>
        <name evidence="2" type="ORF">RA11412_0331</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86630">
        <property type="protein sequence ID" value="BAV86630"/>
        <property type="gene ID" value="RA11412_0331"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0331"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT90123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="176" mass="19461" checksum="946953F975C8CE13" modified="2018-10-10" version="1">MELSIGQNVNLTQAAPEVHNILVGLRWRTDEPLLRECLEAGVLLTAGGRLVNRRDFVFAHQVLDSSASVHRRELMGDDKAQFGIHLPEVPADVDSLEVVLFINGESSIRLNRASGIRARVINPATGATMFRAPLAQVGRSAAVRLMQVYRHRGDWKVRAVCDEWADVPAMLRGFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW91</accession>
    <name>A0A2Z5QW91_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86652">
        <property type="protein sequence ID" value="BAV86652"/>
        <property type="gene ID" value="RA11412_0353"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0353"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="224" mass="23942" checksum="2CF790100ED2214A" modified="2018-10-10" version="1">MSRMSEVQKRNLAFIFMLCVILMLAVLLVWNLMGNKGENKNSAEGAASSSSAPSDGGQQSSTPSSNATGRGDHKCDVPVAPDKAFSAELPSDYRFETTTHGVIYPISAQYGPTYKPGMVVGYCFAHNPTGAALAASQGSTIVGDTRATEAELRGLYSSRIAADLHSAPNSNTERVNARIAGYDIENYSPEKATIGIVVIAKDSDGKNMGFKVSIPLIWEDNDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWA6</accession>
    <name>A0A2Z5QWA6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86660">
        <property type="protein sequence ID" value="BAV86660"/>
        <property type="gene ID" value="RA11412_0361"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0361"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="99" mass="10459" checksum="EDA8A7B1CF70A12A" modified="2018-10-10" version="1">MLRYSAKDQQMLTRQGVTALVNRDNPSKPAKVTLLGSSPKEFRTPAEGASFISTDGSRAYWATSQDGGTVVTADSSGKVEGSHKLASPGEGRVLYRGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWB2</accession>
    <name>A0A2Z5QWB2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anchored repeat-type ABC transporter ATP-binding subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Zinc ABC transporter ATP-binding protein ZnuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_06590</name>
        <name evidence="6" type="ORF">RA11412_0377</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86676">
        <property type="protein sequence ID" value="BAV86676"/>
        <property type="gene ID" value="RA11412_0377"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0377"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022508">
        <property type="entry name" value="ABC_trspt_anch-rpt_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03771">
        <property type="entry name" value="anch_rpt_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="23"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="306" mass="32668" checksum="2604ED6EC5CEAD42" modified="2018-10-10" version="1">MSKGTTVLGSKNDPAPGSENPTLSIQNLYAGYGRRAVLRDFSLTLNPGEFVGLLGANGAGKTTLLRAIMGLLHPASGSIRVLGSTARTARARIGYVPQKHQFQWDFPITVKDAVMTGRTREIGWFRRPKTADWVKVFHALERTDLMQLKNRPIGELSGGQRQRVLLARALAVEPALLLLDEPFTGVDAPTQSALTELYRQLAGEGVTILMSTHDIVAARESCSRLCGVRGSLSLDGKAEDFSPHQLYAWVHGHELEGEGESTGKGGSAGTSPSPEILVPGAGGDSTSSTRQGHPTSHRVTPQEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWC1</accession>
    <name>A0A2Z5QWC1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86686">
        <property type="protein sequence ID" value="BAV86686"/>
        <property type="gene ID" value="RA11412_0387"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0387"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="42" mass="4453" checksum="0CFD7DE7259D9654" modified="2018-10-10" version="1">MSAKTISALQTWLGQPADGVLDGPSPTIEALQNYLNSHEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWH5</accession>
    <name>A0A2Z5QWH5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86746">
        <property type="protein sequence ID" value="BAV86746"/>
        <property type="gene ID" value="RA11412_0447"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0447"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="87" mass="9367" checksum="2A30DDFD71B3C733" modified="2018-10-10" version="1">MTTVFLEVATVCLLVLSWAPIGSFETALALFLVANVLGIITASIAFICAMVGFFKFARYRIVNIILALVSIVINPLTLGFILTSQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWP5</accession>
    <name>A0A2Z5QWP5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86838">
        <property type="protein sequence ID" value="BAV86838"/>
        <property type="gene ID" value="RA11412_0539"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0539"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="378" mass="41995" checksum="BBCF46E7DB195645" modified="2018-10-10" version="1">MHDDGSWKYSPDKDRELTVNADGTWSYRSDGYRHQEVTLHADGSWDTVVNSKSTQEKTHVNPDGSWDKVTKYEAEEGKEAVEVREQVRPDGSWEQKNRYQTIVGSADGTVTITDSKDGQQSTSVSSEWSLVKPFDYEQSSIVQRTEDIKYGVGSNGVIPLIPRTPLPRGVKAVQAPVGSEQERVAIAQQQRLVLTDDNKAGKEPRRRETESHDWGLSNVHLKDDGSYSYSTKEGKGTAEVAADGTWKAKSSDGSTATLNADGSWDSYTEKTMVNMHVNPNGTWVKKTGESAKIQMFADGSWCYEYKDSEITYGTPDGKIYEGVSDKKWREVAQKTWESRGGDKSIKDLDTPRAPLTVKDGVMPLRARNPIAAGQKAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWQ5</accession>
    <name>A0A2Z5QWQ5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06665</name>
        <name evidence="2" type="ORF">RA11412_0355</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86654">
        <property type="protein sequence ID" value="BAV86654"/>
        <property type="gene ID" value="RA11412_0355"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0355"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="167" mass="16846" checksum="39C08C2844883039" modified="2018-10-10" version="1">MNTVGAEPAGSQESAPSEPVPPVSAPQGGQLSPIVYGVSPVSGATTWASLLGLGEVVDIDRAVASGRPLVLVARTTETSIQACFDFLSVHRSGVDIAAILCVADAPGAAVRPVKHKIKILAGANSVISVPWVPRLRAVSLTAEAAADKAVVKAVKNVISGLPAGVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWS3</accession>
    <name>A0A2Z5QWS3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylornithine deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">argE</name>
        <name evidence="3" type="ORF">I6I94_05815</name>
        <name evidence="2" type="ORF">RA11412_0563</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.16" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86862">
        <property type="protein sequence ID" value="BAV86862"/>
        <property type="gene ID" value="RA11412_0563"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0563"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010169">
        <property type="entry name" value="AcOrn-deacetyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01892">
        <property type="entry name" value="AcOrn-deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="189"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="417" mass="45017" checksum="246930D9670A4583" modified="2018-10-10" version="1">MTAAAAPAESASAPLLPESLEYTRRLIAFPSIAQTSNLDIIDYIEAEFARHGHTGHRSYSEDGTRANLFITIPAADGTVNGGIIISGHTDVVPVEGQIWDSDPFTVRVEGTRAYGRGVCDMKGYLGAALWLLPRIRQDRLRVPLHFAFTYDEEVGCVGAPALIEEFTHRGVHPQFCVVGEPTSMRVISAHKGAHRGRVSITGVAKHASLATHGVSAVNAAGEFITFFARLADSWEQEGPFDQAFVVPHATGGVNFARGGVQYNIVAERAVLEYDFRILPSMTTESVVQRLEDELFGAILPRMHARAARAEELAGAEPGSLTAQVQVQHELLAAVPGLGTPDDAELVRLANTLLGLTEAPQKVTYGTEAGLFQRAGVESIVCGPGDIAQAHSPNEWVELEQLRDCERFFEAILGWASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWS7</accession>
    <name>A0A2Z5QWS7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Possible peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0588</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86887">
        <property type="protein sequence ID" value="BAV86887"/>
        <property type="gene ID" value="RA11412_0588"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0588"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="45"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="447" mass="47580" checksum="C323B7693F8F6985" modified="2018-10-10" version="1">MFEVGGKTRDPEALRYVIGHEVGHIAAGHVSYFRLLFTNSFMRLPVVGQALSRAQEYTADNFGYRLSPDGARGGMKVLAGGKYLNKQVNFDEFADRAVTDGGLAVWFVNLISSHPVLTWRAHAIRNRQEPGRLFWRPTYNPPSVPALIPSSEPVPLWPDPLQADAFMQEQKPAWENYSLDTVQLHTPPNPEGAPKFEGTLYTGWQDAAARAAYASRWEQYAASGGQQPMWQPPGYGPAPQPGQPQPYQPNQAQPQPQQYPQPHQPAQPGPQQGTYGYYVQPGQQPGGAQPGTAQPGAQPGGAGQMQQPYGYDPGSQVAPSRPGQPQQPQPGRGYGYYVPTGQDSSTAPQHDSESAQQQAHVPYGIDPQAGSGPAEPETPAEQTPAEPDATCSGTDAPADTGDSAGDSCAGSAADYDSGSSSDVSTDSGSDSGTDFGFSTDFGGSSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWU7</accession>
    <name>A0A2Z5QWU7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86892">
        <property type="protein sequence ID" value="BAV86892"/>
        <property type="gene ID" value="RA11412_0593"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0593"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="483" mass="54012" checksum="DCEFDF4B3A844630" modified="2018-10-10" version="1">MVVFPVVTPELGRYRLGDVPLVHVILAASITVPWLSQAACMPIYRAIELEHKRVAKNRQELTERLETELKEGTVEKVRQLKALLKTPAYQRVSDVAAFARNWPYIYLTTLPLIILFALPLIFIMHWSASAVASYLILSVLNLAFAQLLVLPSLAKNQVDWFFAWLGYAAALLFFPIFWFLPPTAGIIVLLLCLRKNIRQLKVFSRTPIIHVAQDALRGFLTGSVLWADKYVLFVAAHGQINVVAIYISLIPCVLAYNYFFVAEADRVNLVIKKLWSTFEEKPFAQVTNTAKEATHVSNYAMVRSLTVAIFASVITGLIMLVAIPHVFPVGFAGIIAAGLFLVVTLCNYQIEFMGLYRISQLIGVAHLVLVCIIFAIMPNEGGYFPLILGRPYSPLSPTPSTAARGLRRSILSSGVARSPGSFPTRNTTCETSMNLCAAQHRRRAPQTPTTRMSMSLSSWSPPTRTLRVECRRWCTTLSRRTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWV8</accession>
    <name>A0A2Z5QWV8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86823">
        <property type="protein sequence ID" value="BAV86823"/>
        <property type="gene ID" value="RA11412_0524"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0524"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="51" mass="5927" checksum="BB8B366D16292154" modified="2018-10-10" version="1">MRMVLSFRRLSGISSNFTVTLSYKSLPQRFIPAKRRKVQGEGAENRQRATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWW8</accession>
    <name>A0A2Z5QWW8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86880">
        <property type="protein sequence ID" value="BAV86880"/>
        <property type="gene ID" value="RA11412_0581"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0581"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="319" mass="35383" checksum="19AA05EA14C53F64" modified="2018-10-10" version="1">MPVYNTADSVVRAIESVLAQTDPDFELLVMIDGSPDNSAQVINDYVAQHPDQRIRVFDNPNNQGVSAVRNQGLDNAHGTWVAFIDSDDAYHPEFLEKLHEAARTHDADIAVCGHTLIDPNTGRTPRRRFPLGAFRGEEAALKLLEDRMTPYLWDKIFRTSTIAKTRFPHDIHRAEDAYFVTAAFTNAQQVVTISDFLYDYTVDAGGLTWGRITPVDESVRLVAYLRDAAGGLTSSPRGRKAMSTSHVLTFLNNAQQALIVGGPDAEAVIKKCRSEFSWSQVFDTVQTRVIYGAAGALLKISPALYRVLYGAYVKRTYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX08</accession>
    <name>A0A2Z5QX08_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rplI</name>
        <name evidence="10" type="ORF">I6I94_06245</name>
        <name evidence="11" type="ORF">NCTC10207_02409</name>
        <name evidence="9" type="ORF">RA11412_0455</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI25085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887421.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86754">
        <property type="protein sequence ID" value="BAV86754"/>
        <property type="gene ID" value="RA11412_0455"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0455"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="8">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT88153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VEI25085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="150" mass="15445" checksum="6D337D51B4FF0076" modified="2018-10-10" version="1">MAKIILTQEVTGLGAAGDIVTVKNGYARNYLLPRGFAVTWTVGGEKQVESIRAARAARAKASLEEAQALAAALSAKPVVVAHKAGADGRLFGSVKADAIADAIEAAGIGSIDKRTIHLGSAIKRTGEYQVTARLHQDVVANVTLDVVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX21</accession>
    <name>A0A2Z5QX21_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
            <shortName evidence="7">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">serS</name>
        <name evidence="11" type="ORF">I6I94_05380</name>
        <name evidence="10" type="ORF">RA11412_0673</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86972">
        <property type="protein sequence ID" value="BAV86972"/>
        <property type="gene ID" value="RA11412_0673"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0673"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="139"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="7">
        <location>
            <begin position="230"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="348"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV86972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT90019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="433" mass="47967" checksum="1FF4098D7742D618" modified="2018-10-10" version="1">MIDINLLRENPEIFRASQRARGKDEAHVDRILEADAARRASIGTYENLRAEQNAFGKQVAKAPKEEKPALVAQAKELAARVAEAKAESEAKTAEYEELLSSIENLIIDGVPTGGEDDFVVLKEVGTPRDFAAEGFEPRDHLEIGELVGGIDMARGAKVSGSRFYFLKGQVARLEQALMWMALDLATANGFTMMTTPTLVRPEIMNGTGFNVKHDDEIYRLERDDLYLVGTSEVALAGYHMDEILDLSDGPKKYLGWSSCYRREAGAAGKDTRGIIRVHQFNKAEMFVYCQVEQAEEIHEQMRALEEEMLQKCGLAYRVIDTAAGDLGTSAARKFDCEAWVPTQGTYRELTSTSNCTTYQARRLNIRERTADTVDDAGNVRKGRTRAVATLNGTLATTRWVVAILETHQQPDGSVRIPEALRPYMGGAEVIPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXC7</accession>
    <name>A0A2Z5QXC7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HipA_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86993">
        <property type="protein sequence ID" value="BAV86993"/>
        <property type="gene ID" value="RA11412_0694"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0694"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012893">
        <property type="entry name" value="HipA-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07804">
        <property type="entry name" value="HipA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HipA_C" evidence="2">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="100" mass="11328" checksum="9339EB57CCDA8113" modified="2018-10-10" version="1">MRTLPVNWRSEEALLKVSPERIPYLVENEYEHLRAASNLKIPVAQSTLIYDRENTPGLLISRFDRGPQGERYALEDAAQILDIPPAANIVQTVTLPVNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXD2</accession>
    <name>A0A2Z5QXD2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87115">
        <property type="protein sequence ID" value="BAV87115"/>
        <property type="gene ID" value="RA11412_0816"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0816"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="79" mass="8401" checksum="66B0570C1CA58FCA" modified="2018-10-10" version="1">MIGVYAGVSVKPEHVEEFLASTPALVEASRKDAGNISYDFGPATGETPAGEPRVFALLSVGNHSRHSKRIWRPSISGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXE7</accession>
    <name>A0A2Z5QXE7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86904">
        <property type="protein sequence ID" value="BAV86904"/>
        <property type="gene ID" value="RA11412_0605"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0605"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="89" mass="9347" checksum="2F317250F931C72E" modified="2018-10-10" version="1">MLTVQGRNINGAGAKVKVGQGPDQLKGVRGIQGRAVDLRGTIMQTQHLNYGFIDQAAAVNIQHHAVLTVKLTDEGISSSASVSRAIHCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXG9</accession>
    <name>A0A2Z5QXG9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="18">PTS glucose transporter subunit IIA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="17">Phosphotransferase system IIC component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I6I94_04665</name>
        <name evidence="17" type="ORF">RA11412_0833</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87132">
        <property type="protein sequence ID" value="BAV87132"/>
        <property type="gene ID" value="RA11412_0833"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0833"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="15">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="16">
        <location>
            <begin position="109"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="14">
        <location>
            <begin position="565"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="BAV87132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QQT89891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="695" mass="73081" checksum="1521127913A64594" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXJ5</accession>
    <name>A0A2Z5QXJ5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GlsB/YeaQ/YmgE family stress response membrane protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Transglycosylase associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_05455</name>
        <name evidence="8" type="ORF">RA11412_0655</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86954">
        <property type="protein sequence ID" value="BAV86954"/>
        <property type="gene ID" value="RA11412_0655"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0655"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="87" mass="9036" checksum="EF561DE6A7C3416E" modified="2018-10-10" version="1">MLGLIGMIIAGAIIGALARLIMRGHQNISVLWTIILGAVGAFVGGGIASFFGVADTAGIDWIRWILSVIAAIIAISVYLSVTGRKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXW6</accession>
    <name>A0A2Z5QXW6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">D-serine/D-alanine/glycine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I6I94_04050</name>
        <name evidence="9" type="ORF">RA11412_0999</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87298">
        <property type="protein sequence ID" value="BAV87298"/>
        <property type="gene ID" value="RA11412_0999"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0999"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="8">
        <location>
            <begin position="29"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT90088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="491" mass="52805" checksum="CCCEF417A84603F6" modified="2018-10-10" version="1">MQQPHENAAPAAESTGQAEELHRGLSNRHIQLIAIGGAIGTGLFMGSGKAISKAGPSILLVYIVIGAAIFLVLRAMGEILLSNLKYKSFSDFTADLVGRPAGFFLGWSYWFMWVVTAVADIIAIVDYSQLWWPNLPKAVPALIVIIALLALNLPSVKNFGEIEFWFAMIKIVAICALILVGIVMVTTSFTAPNGSHAQIANLWEHGGFFPNGVFGFLGAFQIAIFAFMGSELVGTTAAETQNPTVTLPKAINSVPVRIIIFYVGALLVILMVNPWNEIDPAKSPFVTMFSLAGIGIAAHIVNAVVLTSATSSANSGIFSTSRMVYGLAQEGDAPKSLGVLSAQGVPRNALFLTSTLLLSSIVLLYAGDSIIGAFTLVTTMAAVLVIFVWSMILISYLCYRRKRPQLHTQSVYRMPGGVVMCWVVLAFFAFSVCILATAEDTRAGLMLMPIWFGGLAIGWFVKNRLHPEVPETSITQSNPIVDLKQTSDGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY70</accession>
    <name>A0A2Z5QY70_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-inositol 3-phosphate glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_03595</name>
        <name evidence="5" type="ORF">RA11412_1116</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87415">
        <property type="protein sequence ID" value="BAV87415"/>
        <property type="gene ID" value="RA11412_1116"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1116"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="14"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="347" mass="37740" checksum="03163C524495CF47" modified="2018-10-10" version="1">MAQELYIATNNGDMGGGEVMLLNIARAARSLGYRVTVIGPAHPPQLVEAAADEGFARVVLPARTRSQYMMQLRAWHSAHKKVLLWCNGLVPAAATGGRKNRIVHLHQIPEGLNAKLVPFARRKASATLVPSNFMARQINGAQVLSNWVSEVPTDLKHDNTDVIRVGFIGRLSPIKGIVPLCKAIATLTQGGGAYRLVVAGEPVFTSEVEQEQVERSLSRIAEHTERLGWATPEALFNNVDMLVVPSLVAESFGLVAAEAMSARVPLIVSDSGALPEIVGENYPYIVPKGDEAELARTISIVAEQLSSDSEKLTSTVSDAFWRWQELYSPEAGKERVREILEQHISPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY76</accession>
    <name>A0A2Z5QY76_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA (Guanine46-N7-)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87296">
        <property type="protein sequence ID" value="BAV87296"/>
        <property type="gene ID" value="RA11412_0997"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0997"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="151" mass="16891" checksum="ADF93C2C034DCF05" modified="2018-10-10" version="1">MSSQEQNTSAGASLEPETSQDPGKKQVPPEFFRQPYSFVRRGDRLTSRRQKAWDTYSPTHVLDIPRLRADTSVAPEATFDPVTIYGREAYQVVEIGSGLGEAIVHRASEIPEANFLAVEVYTPALRICCLRWGRPGLRMCASLRPTPRTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY88</accession>
    <name>A0A2Z5QY88_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87280">
        <property type="protein sequence ID" value="BAV87280"/>
        <property type="gene ID" value="RA11412_0981"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0981"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="117" mass="13179" checksum="CA2494F8A1167E8B" modified="2018-10-10" version="1">MGMNFFKYTLVRFGLLVFFFYLYELLGAGILVSGGCAIVSAFAVAYIFFPRLHAAASQDTARFFKRTPKVKNKEEEENRAIEDELVESQKKNLGKTSKQLPASAYVTGRARRVLASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY94</accession>
    <name>A0A2Z5QY94_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Capsular polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87422">
        <property type="protein sequence ID" value="BAV87422"/>
        <property type="gene ID" value="RA11412_1123"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1123"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="226" mass="22614" checksum="F4688B216425FF52" modified="2018-10-10" version="1">MTILDFVRTTRANLVLLILGIIIGALLGVGYSLTQPKVYAASASGYVTIGSGGTIDVLSGSSAAKDRARSYSAIVSSEAVAKIIQEKNPNMGMTVSGIRGSVTASTDENSSLIKVSAHASTPEQAQVLANSALHATAEYIKNIEGNNGGSGNAANSNGGNNATPNAENGNTAGASASANTAVSGNAANNIRVIPLDNASINPPLVSPTTPVTPSSVQSPGSFLCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYB8</accession>
    <name>A0A2Z5QYB8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MHS family MFS transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_03450</name>
        <name evidence="8" type="ORF">RA11412_1159</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037232751.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87458">
        <property type="protein sequence ID" value="BAV87458"/>
        <property type="gene ID" value="RA11412_1159"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1159"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="31"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="473" mass="51063" checksum="17524B83B6DC8FE3" modified="2018-10-10" version="1">MSAQAHAASGEPVKRTPDTTSLANATPRSRVILASLVGTTIEFYDFYIYATAAVAVFPALFFASKDPTTELLASFATFGVAFIARPLGSVVFGHFGDKIGRKATLVGALLTMGLATFLIGLLPTYHQIGLWAPTMLTIMRFCQGLGLGGEWSGAALLASEYAEEGKRARAAMWPQLGAPIGFVFANGFMLLLTSWITFNSTVDGKNLNHPFLVWGWRIPFLLSIVMVAVGLYVRFKLEETPVFAKAVENDEKVKAPLVEAFKVAWWPMIQGTFIMVACYVLFYLMTAWILSYGIGKVENGGLGIAYRDFLVIQLISITGFALFIPLSGWLADRFGRRQQQLWTTIGMALFGCMFTLMIAPSVVGTGASANTTAVTVFMFIGMCLMGLSFGSMSAYLPELYPTNVRYTASGIAYNMASILGAALTPFVAVWLNQLGGVGAVGVYLAVASALSVVFILLTHETRDVDMNAVGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYF2</accession>
    <name>A0A2Z5QYF2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_03880</name>
        <name evidence="3" type="ORF">RA11412_1041</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87340">
        <property type="protein sequence ID" value="BAV87340"/>
        <property type="gene ID" value="RA11412_1041"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1041"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="12"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="461" mass="49469" checksum="2CCDEDBD274D50D7" modified="2018-10-10" version="1">MAFTKLAQDRPRILIVGGGYVGFTVAKKIQKAVKATGGVVTIVEPNPYMTYQPFLPEVAAGSMEGRNATVPLRQHLRDTEIIPGLVVSVNHAARTAVVEPIDSGEPFELQYDEIILGAGSVTRAFPIPGLAEVAIGMKTVEEAVSVRNWVLERIEVASVLEDADARRRALTFVIVGGGFAGVETISELEDMAREAVNRNDRLTPSDLRFVMIEAAPRIMPEVPEDRAEKVVAELRARGIEILLNTSLSDATGGNLQLINMADKSPAGEIDTDTLIWTAGVAASPMLKNTDFPIDERGRVRVNADLRVAGDAGVVEGAWAAGDNAAVPDLSGGGVGGFCVPNAQHASRQALVLAKNILAARRGEPLTDYYHETIGVVAGLGLWKGVANFKGKTFAGPLAWIMHRGYHGSAIPTTERTVRVMTTWALNQLFGRDTTTIRRQRTPRLAFQEATGTAPAKTKAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYI5</accession>
    <name>A0A2Z5QYI5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Membrane-associated zinc metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RA11412_1229</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87528">
        <property type="protein sequence ID" value="BAV87528"/>
        <property type="gene ID" value="RA11412_1229"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1229"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ_6" evidence="11">
        <location>
            <begin position="9"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="10">
        <location>
            <begin position="73"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV87528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="265" mass="28318" checksum="76B4ADB187DD0767" modified="2018-10-10" version="1">MQRFFSAVPAKTAGLRAGDTVLAVNGTETSSWTAVSSAIRAAGTTPSEIKIMRDGREQTLTITPVQLVRPVVDEQTGQYARNEDGSFKTVSGGFVGISPTSELKPGNLSDVPPNVGHTLARIAGSMWSLPQRVWDLGVTLVTNGDRDANSPVSVVGVSRIAGEVASTDQIDRTSKEATLVSLVASMNLMLFAFNLIPLLPLDGGHVFGALWEATRRAFAKLTRREDPGPFDPIKLMPLTYVVAGAFILMSVILIAADIIKPIRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYM0</accession>
    <name>A0A2Z5QYM0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar hook-length control protein fliK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87446">
        <property type="protein sequence ID" value="BAV87446"/>
        <property type="gene ID" value="RA11412_1147"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1147"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="161" mass="17625" checksum="074EDB4454AE223E" modified="2018-10-10" version="1">MKELDNLRSSYENTLAKVKPAPEPQRQQGDEEGSNDENGKKEQARQALDDDTIKAIEEMSTGAAAGEYTSSAAEHAMTGTHTEGTSTVVGNPRMTETTYKGQPARLLEVCVDSSNVKTVDKDGKELPSDNTPKRSLNIYTLVQVDGKWKIAEHDWPNNANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYQ5</accession>
    <name>A0A2Z5QYQ5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA (Guanosine(18)-O)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87598">
        <property type="protein sequence ID" value="BAV87598"/>
        <property type="gene ID" value="RA11412_1299"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1299"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="302" mass="32214" checksum="00109E9D4DF0E04D" modified="2018-10-10" version="1">MIMSNPQADRVRDIAKLRTRAGRKRGQFLVEGPQAVREALHAHLRRPVLDAVYVTEEAFDRHPDIAELLEEVHGTPTPEQGRRVFMRVVTDDVLQAMADALTPQGIIAVSFKLDAPAGRLWGEGALNPRLIAVLSRVQDPGNAGTILRVADAAGADLVVASKGTVDLYNPKTVRATAGSLFHVPLIQGVDLEDFAEDAKSQGMTVLAADGYGTVDLQQLVEYSLARPANIETPVPAGVKGSFNLSKPTVWLFGNEAQGLNSEEKAASSMRVAVPVYGAAESLNVGTAAAVCLYASAMAQNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYU8</accession>
    <name>A0A2Z5QYU8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septum formation protein Maf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87461">
        <property type="protein sequence ID" value="BAV87461"/>
        <property type="gene ID" value="RA11412_1162"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1162"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="70" mass="7337" checksum="4F4595A2D0C00BD0" modified="2018-10-10" version="1">MSEQEIEDYVATGEPLQVAGSFTLDGYGAAFIRGVYGEPHAVIGLSVNALKDMLSRLGVPLSALWAEPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ22</accession>
    <name>A0A2Z5QZ22_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87698">
        <property type="protein sequence ID" value="BAV87698"/>
        <property type="gene ID" value="RA11412_1399"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1399"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="94" mass="10219" checksum="F4CB696EFDDD7167" modified="2018-10-10" version="1">MWRDGVLARRYASAYARISRAELSYVSRLILLVSVSLTFFGCIMVLSASSVRMISQGMSPFNQGNDSCSTPSGVLPSCWWWGSCRWGGIGVGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ34</accession>
    <name>A0A2Z5QZ34_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87494">
        <property type="protein sequence ID" value="BAV87494"/>
        <property type="gene ID" value="RA11412_1195"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1195"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="12"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="296" mass="31630" checksum="4CC1874FF3CBEA2C" modified="2018-10-10" version="1">MLCSVPTGRENNNCADVRNTADPTSGTVRIDGVDAIAHPQRARASLGLALGGDTGFYPRASARDNLLFFADLAGVSARKRHTQVASALERVDLADVAAKKVQEFSRGMKQRLHIGRALLGEPKLLLLDEPTSGLDPDISLTIRQLIRSLADDGTAILLTSHLLGEIEELAHRVTVIGAGRVAVSGTVADVATHAGISATTVGRVGANAGPVLQELTRSLGDAGTVLLTPRGSEWEITVYWNERSASEGPRPFSTEHAEALLTRILTEREVQMLTPLYTRPATLEEAYLAMAEGLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ43</accession>
    <name>A0A2Z5QZ43_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative tetratricopeptide repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87560">
        <property type="protein sequence ID" value="BAV87560"/>
        <property type="gene ID" value="RA11412_1261"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1261"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="99" mass="10879" checksum="20B8E33226250026" modified="2018-10-10" version="1">MVREIIFGARIQKLADELAAAGKLPEDTLPRSPSGRVDKSAAAQEFEKFALAVEDAPDDCVSWFNLSCMYDACGERKRARAAMRNAVSLHRGRPAKPMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ54</accession>
    <name>A0A2Z5QZ54_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">UDP-N-acetylglucosamine 4,6-dehydratase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="7">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">capD</name>
        <name evidence="6" type="ORF">I6I94_02210</name>
        <name evidence="7" type="ORF">NCTC10207_00849</name>
        <name evidence="5" type="ORF">RA11412_1466</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87765">
        <property type="protein sequence ID" value="BAV87765"/>
        <property type="gene ID" value="RA11412_1466"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1466"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041561">
        <property type="entry name" value="PglD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17836">
        <property type="entry name" value="PglD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PglD_N" evidence="4">
        <location>
            <begin position="169"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="310"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VEI22763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="634" mass="71398" checksum="BF035D1F88A75487" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ63</accession>
    <name>A0A2Z5QZ63_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP synthase epsilon chain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">F0F1 ATP synthase subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_02155</name>
        <name evidence="3" type="ORF">RA11412_1476</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87775">
        <property type="protein sequence ID" value="BAV87775"/>
        <property type="gene ID" value="RA11412_1476"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1476"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="90" mass="9694" checksum="A21F3B6F61CDABFA" modified="2018-10-10" version="1">MALTVEVVSRERVVWTGEASYVRVRTVEGDLGISPGLIPTCALLAEDGEMLLRPVGGQDLKTRLHQGFMTVSNDKVTIAAKHADFTVPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZC7</accession>
    <name>A0A2Z5QZC7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylated-DNA-protein-cysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_1352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87651">
        <property type="protein sequence ID" value="BAV87651"/>
        <property type="gene ID" value="RA11412_1352"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1352"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="6">
        <location>
            <begin position="52"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="141" mass="15644" checksum="EB0545A43356D451" modified="2018-10-10" version="1">MAQAIGADAERRGEHIYVAPARILAQTERELDEYFRGRRTDFEVPLDPDGTDFQLAVWDYLKTVPYGYTVTYGEISRMVGPGAPAQAVGQAVGHNKIAIIIPCHRVLGAGGKLTGYAGGLDRKRWLLDREEPKDIRSGRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZE2</accession>
    <name>A0A2Z5QZE2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87865">
        <property type="protein sequence ID" value="BAV87865"/>
        <property type="gene ID" value="RA11412_1566"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1566"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="105" mass="11783" checksum="8414E5B4A6F287FE" modified="2018-10-10" version="1">MIMADWIASNPTFFPMGTFDVEAQRKRLNQGWDTLGLEHPWGAYTGDAAASDLYSSRFGWKNPTLRPMQEVVANAARAMKGGGMMCIEAPWDRVKLRLDSSLPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZJ0</accession>
    <name>A0A2Z5QZJ0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease NucS</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nucS</name>
        <name evidence="4" type="ORF">I6I94_02150</name>
        <name evidence="3" type="ORF">RA11412_1477</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NucS endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87776">
        <property type="protein sequence ID" value="BAV87776"/>
        <property type="gene ID" value="RA11412_1477"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1477"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="237" mass="26063" checksum="3903478A5F6EEFF5" modified="2018-10-10" version="1">MRVVIAECSVDYEGRLRAHLPRATRLLMVKGDGSVLIHSDGGSYKPLNWMSPPCTLAVAARDSIPAATLEELEEEVQQLWTVQAAKSDDRLLIKVFEVIHEHEHSLGTDPGLIKDGVEADLQRLLAEQIETLGSGYSLVRREYPTAIGPVDIMAKDPNGASVAVELKRVGDIDGVEQLTRYLELLNRDPLLAPVKGVFAAQKIKPQARTLAQDRGIRCIALDYDAMRGVDDAADRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZL9</accession>
    <name>A0A2Z5QZL9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murI</name>
        <name evidence="10" type="ORF">I6I94_02035</name>
        <name evidence="9" type="ORF">RA11412_1507</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87806">
        <property type="protein sequence ID" value="BAV87806"/>
        <property type="gene ID" value="RA11412_1507"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1507"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="48"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="340" mass="36976" checksum="E573C70A54BDC0A4" modified="2018-10-10" version="1">MFEGNNKSAGKTTVSESHNTTEQTHARTPWGTLAPITPSASAPIGVFDSGVGGLTVARAIMDQLPYERIIYVGDTAHGPYGPLKIAQVRANALRIMDELVDSGVKMLVIACNTASAAVLRDARERYTRQYHIPVIEVIQPAARRALAATRNRTIGVIATEATVTSRAYEDTFAIAPNLRVHSVACPRFVEFVERGITSGPELLQTAQEYLQPLKDAGVDTLVLGCTHYPLLTGVISYIMGEDVTLVSSADETAKDVYRELLTGGLETPVLNNQFEHEFLATGQSETFEHLARRFLGPEVTNVRHTSSVAERFPTGSLTALTPDMMSTHTRIDPQLTPTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZP6</accession>
    <name>A0A2Z5QZP6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Riboflavin transporter PnuX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_1629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1629"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006419">
        <property type="entry name" value="NMN_transpt_PnuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36122">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04973">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="100" mass="11649" checksum="D842D9E13FBDCD14" modified="2018-10-10" version="1">MGSYEPVWSDAWIFTGSLLATYGMARGWVEFWLIWVAVDLVGVPLLWGAGYYATSLMYVFYGCFTLVGFFVWWRTRNRETQRTRVQTQFPDITVKVEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZQ4</accession>
    <name>A0A2Z5QZQ4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Riboflavin transporter PnuX</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">RA11412_1628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87927">
        <property type="protein sequence ID" value="BAV87927"/>
        <property type="gene ID" value="RA11412_1628"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1628"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006419">
        <property type="entry name" value="NMN_transpt_PnuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04973">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="142" mass="15055" checksum="483CAEF896730779" modified="2018-10-10" version="1">MEFLRWLFDAQIHVGDQSLLVREVLGNAFGLASALGGMRRKVWAWPVGIIGNLLLFTVFMGAFLAAPTREHAGPGGTAAHVHHRIGVGLVPVAANPRNRRCTRSRYGGHTAVGLRVGTGGTNHCDGRRDCGSHPGISGNGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZR3</accession>
    <name>A0A2Z5QZR3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87781">
        <property type="protein sequence ID" value="BAV87781"/>
        <property type="gene ID" value="RA11412_1482"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1482"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="63" mass="7066" checksum="3D4B0CE196FA2C78" modified="2018-10-10" version="1">MSEETRTEFDPSRYIFTDPGVPTAIRSRTVLPARRENFEVTTADGKRLVGELALPEGTVKRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZU0</accession>
    <name>A0A2Z5QZU0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-Acetyl-D-glucosamine ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87883">
        <property type="protein sequence ID" value="BAV87883"/>
        <property type="gene ID" value="RA11412_1584"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1584"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="53" mass="5638" checksum="6533F2DB0D935506" modified="2018-10-10" version="1">MTHPHVCGEHGRTITLGGYFEGSSPRMRGTLIGEFPVGDKFGLIPTYAGNTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R019</accession>
    <name>A0A2Z5R019_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide 4</fullName>
            <ecNumber evidence="10">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome aa3 subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I6I94_00875</name>
        <name evidence="12" type="ORF">RA11412_1806</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of cytochrome c oxidase, its function is unknown.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Associates with subunits I, II and III to form cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cytochrome c oxidase bacterial subunit CtaF family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887290.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88105">
        <property type="protein sequence ID" value="BAV88105"/>
        <property type="gene ID" value="RA11412_1806"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1806"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021050">
        <property type="entry name" value="Cyt_c_oxidase_su4_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12270">
        <property type="entry name" value="Cyt_c_ox_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017385">
        <property type="entry name" value="CtaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV88105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT89224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="133" mass="14910" checksum="36C47888FE4066AE" modified="2018-10-10" version="1">MKVLGKVFLYLGIFFIPVGIIYGFMTNFDEWAGFPALLVTGLMCFFLAFFLMFTEKKLGSQPMDNYTGEIAESAGEYGFYSPWSWWPFAIGVACMFVVLGAAIAWWVVLIAIPFAAAAVIGWVYEYSRGDHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R083</accession>
    <name>A0A2Z5R083_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88128">
        <property type="protein sequence ID" value="BAV88128"/>
        <property type="gene ID" value="RA11412_1829"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1829"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="328" mass="34739" checksum="C9B38978076D0920" modified="2018-10-10" version="1">MTIRVLLNGSIYTPADPYATAILTEHGTVRWAGSDAGARSITDNTMETIDLNGRLVTPTFTRALAPVTGKTTAEILTYLTTAHHAGYHTHTLTTDPNTLQPLIEAAQQFTSTHTTADLRILLTNTPPHALTETITHTRETLNGTPLTLAGLHANTPAEAQHLADTAAQTQLTLCINAHSHLTQAAATAQTIRRTHPHLTLRLDTIKTTPEETLNDQELQALANSRISLGLQTTAENADLARHANTIGTPISIGSDPTLDAPLGWQAVKIFATAPAESPHAPPSPHSPAAPTVRSPTLTPSPVSSPPTPPPTSPSGMSPSSWYKPPTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0D1</accession>
    <name>A0A2Z5R0D1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted D-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88225">
        <property type="protein sequence ID" value="BAV88225"/>
        <property type="gene ID" value="RA11412_1926"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1926"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="309" mass="34216" checksum="685CB08C952763AB" modified="2018-10-10" version="1">MSSSISQAVRELAEPKLAEFTAKLIPTVDPARILGVRMPALRKLAKKLLREHPPEVTEFKAAVPHDFQEEDLLHVLLLNEERDFATWHAEITNFLPYMTNWTLTDAVSPACVKGRNAANLPQLERACLDWMVDDRVYVQRLGVVVLMSLLGTEYFSPEHLRKEYEYNGIDTCAVDGMCQTRCPVNINTGDLIRRLRSENQDKLAATGWKVAAQQWGVMDKVAGKALTVAQKLPFPVVHGTTNIARKVMGDDTVPSYKKGLPVGGLARKPHKDATAEIVFFPACVNSMFGGVDGDGKHDPVRTPGVHPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0F7</accession>
    <name>A0A2Z5R0F7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycine betaine transporter OpuD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_1711</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BCCT transporter (TC 2.A.15) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88010">
        <property type="protein sequence ID" value="BAV88010"/>
        <property type="gene ID" value="RA11412_1711"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1711"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="280" mass="30055" checksum="DB1F94C9583F78DC" modified="2018-10-10" version="1">MKSRKYTSVFIGSLIVSLILVALGFVPGYGEVSKNWRALIGTDFGWFYLLLVTLIVLVCGFFVLSPMGQIKLGEPDSKPEYSTGSWIAMLFSAGMGIGLVFYGAAEPLSHFANKTPHAAPGSQQAMADSFQFTFFHWGIHAWAVYGIVAMALAYFGFRKEEKYLLSVTLKPLFGKKTDGWLGYIIDIVTVVATVIGVATTLGFGAIQINGGLSYLTDNAIPNNMEVRTVIIVVTTALFVLSALSGLGKGIKILSNLNMILAIALLAIAIAVGPTVKILTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0K3</accession>
    <name>A0A2Z5R0K3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86389">
        <property type="protein sequence ID" value="BAV86389"/>
        <property type="gene ID" value="RA11412_0090"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0090"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025584">
        <property type="entry name" value="Cthe_2159"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14262">
        <property type="entry name" value="Cthe_2159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016351063" evidence="2">
        <location>
            <begin position="33"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="193" mass="19798" checksum="564746AA7F5D23B6" modified="2018-10-10" version="1">MKKSPLNVAASLPLIVGLGLAGCSGSNNESSAAPKDSLGPTNAAPAQQAKAPSGKYSSNTKTGEKINAETHHTHGSLTWDTGSEIRLDLANEPSADGVSVEDGALVITKAGNYHLSGDYTGQVRINTAEPETVRLILDNVSITNSTGPAITASGGGTTIVYTMAGTTNTVSDGEQYTVTGKKNQTQRSTPPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0N1</accession>
    <name>A0A2Z5R0N1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_11270</name>
        <name evidence="3" type="ORF">NCTC10207_01320</name>
        <name evidence="1" type="ORF">RA11412_2046</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887965.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88345">
        <property type="protein sequence ID" value="BAV88345"/>
        <property type="gene ID" value="RA11412_2046"/>
    </dbReference>
    <dbReference type="GeneID" id="32321407"/>
    <dbReference type="KEGG" id="raj:RA11412_2046"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI23221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="61" mass="6469" checksum="B39B4C2BC54460FA" modified="2018-10-10" version="1">MNLKTYDAIAHREGTGWVVDVPELETAGQPTNFSGILLAATEAISRATGLEPGNFGVRLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R105</accession>
    <name>A0A2Z5R105_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_11235</name>
        <name evidence="1" type="ORF">RA11412_2053</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88352">
        <property type="protein sequence ID" value="BAV88352"/>
        <property type="gene ID" value="RA11412_2053"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2053"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="264" mass="27792" checksum="A45B07E5ACD9CEE1" modified="2018-10-10" version="1">MAIHGADGAGRAHPIIELKYNPHEGIEEPYLVLADGENGVAAAKDLATYISRAKSVDKGAAIRLIARGTVLGVFACSLAPETLLDATPTILGTRALTLAAPSQLDIVVEAQALLDRLARIQESKMVLYLPPVTVNAVWAGQSAPVSGWARVGAVAASEFRRACREGLEAVDRSLPENPGAAVLATVRSRIWSSPMVLEHLPEFDNVSVPTGAAFALKVFGFLPDAFEGQLPVFVARSKSGEWTRIAAPGGQVLVRAATPSLQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R115</accession>
    <name>A0A2Z5R115_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="3" type="ORF">I6I94_11190</name>
        <name evidence="4" type="ORF">NCTC10207_01342</name>
        <name evidence="2" type="ORF">RA11412_2063</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA-binding protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887976.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88362">
        <property type="protein sequence ID" value="BAV88362"/>
        <property type="gene ID" value="RA11412_2063"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2063"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI23242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="81" mass="9287" checksum="07A7EE17C85930D9" modified="2018-10-10" version="1">MLADALEHLVRGIVEHPDDVKVRVRQQRYRETLQVRVHPEDLGRVIGRSGRTAKSIRTVMDAISDGSQVRIDIVDTDKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R149</accession>
    <name>A0A2Z5R149_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">smc</name>
        <name evidence="10" type="ORF">I6I94_11125</name>
        <name evidence="9" type="ORF">RA11412_2074</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88373">
        <property type="protein sequence ID" value="BAV88373"/>
        <property type="gene ID" value="RA11412_2074"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2074"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340180" description="Chromosome partition protein Smc" evidence="7">
        <location>
            <begin position="18"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="SMC_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="774"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="338"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="793"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="877"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="1192" mass="128599" checksum="A04A473EB7080770" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1C4</accession>
    <name>A0A2Z5R1C4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88350">
        <property type="protein sequence ID" value="BAV88350"/>
        <property type="gene ID" value="RA11412_2051"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2051"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="133" mass="15196" checksum="D9D6D71B4DFE1E60" modified="2018-10-10" version="1">MHDDVPEFVYDAFYPQGWQQRQLNDLKEVLDQEPQNVSVALEGERPVGWVCTRIHPEDQMGEIYVIAVDPEYQRRGVGQQLMEHASAQIKDAGMRMVMVETGGDSGHAPARALYESEGFVRWPVARYFKDLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1G2</accession>
    <name>A0A2Z5R1G2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NCTC10207_01466</name>
        <name evidence="1" type="ORF">RA11412_2203</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">NCTC10207</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88502">
        <property type="protein sequence ID" value="BAV88502"/>
        <property type="gene ID" value="RA11412_2203"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2203"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046040">
        <property type="entry name" value="DUF5998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19461">
        <property type="entry name" value="DUF5998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VEI23359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <sequence length="197" mass="21489" checksum="38BD4D83151A6839" modified="2018-10-10" version="1">MAYMDESPREKLAADIKHAGFYPELVLEVVDDALAGLEPDAHFVQHETHFSRNDLHRHITVMVLCGSQLVLAHLDDSHLEEDAQGTVAHVSVEAVKLSALRAVTISYGYDQPQIYRPGMSPTEVSFQVAWTGSLRIDAAPATCPDPTCTADHGYTGSASLEDIAVRVSATADGPDAVKQARYFARALHRAHMHSDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1G5</accession>
    <name>A0A2Z5R1G5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_2326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88625">
        <property type="protein sequence ID" value="BAV88625"/>
        <property type="gene ID" value="RA11412_2326"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2326"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="5">
        <location>
            <begin position="11"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="203" mass="22527" checksum="E81AA42D55B24B75" modified="2018-10-10" version="1">MNLVRDYRSHTQVVELANRLLEARRPGKDSTEFSWAPPLRLVSQRGAGVECEWFEYADDEAQAQGIAEDILDLMNKDGLPASEIAVLFRTNAQSAVIESALSAAGVPYQLRGAEQFFERPEVKQAVLALRGSAKGTDGSEHAPSLVRDVLSSLGYSEKAPTSGVRCGRSGSRWRRWCLWLMLYTPSAKSRLLHKHPLSRGCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1G7</accession>
    <name>A0A2Z5R1G7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA helicase RecG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88390">
        <property type="protein sequence ID" value="BAV88390"/>
        <property type="gene ID" value="RA11412_2091"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2091"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="128" mass="13575" checksum="251E08395E0E2632" modified="2018-10-10" version="1">MNAGHGTGEGASPKPSTSAPSLFDGLDSGALWGEFARKPSRPRNAAAQRKDTHADGAAASTRGDKSNKNASRGKSSVQQETETQQEAAHHTKGTRRGVKPLAPNKSQSQTLTTMLRGMYLRVCSQMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1K4</accession>
    <name>A0A2Z5R1K4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_2318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88617">
        <property type="protein sequence ID" value="BAV88617"/>
        <property type="gene ID" value="RA11412_2318"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2318"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005372">
        <property type="entry name" value="UPF0182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344">
        <property type="entry name" value="PTHR39344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03699">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
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        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="792"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="861"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="794"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="867"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="907" mass="98615" checksum="EBA42DAD026FDBBD" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1N0</accession>
    <name>A0A2Z5R1N0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_0450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86749">
        <property type="protein sequence ID" value="BAV86749"/>
        <property type="gene ID" value="RA11412_0450"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0450"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="362" mass="39083" checksum="EB5AE997D159F4C6" modified="2018-10-10" version="1">MLQVQNLSKRYGEKTAVNDVSFTVPDGKVTGFLGPNGAGKSTTMRMIVGLDRPTAGTALVDGSQYTSLKSPLGSVGALLEGKTHPGRSAYNHLRSIAYTHNIPLARVHEVIEMTGLNAVAKRKVGGFSLGMGQRLGIAVALLGNPHNVILDEPVNGLDPEGVVWVRQLAKHLASEGRAVLISSHLMSEMAQTADDLIIIGRGRLLEHTSLSELLSRVGGHRVLVRTDERERYAQLLNHYSIQHTPVDTDGLLVSADARALAELAFNEHILLYTLAPQEASLEDVYLEITRSEVEYASTAVAGSGPVNSQQPVAMDPTGGAPQAPYTARRWGNNSFSSNPNTRKPQRTLRGRLRPQTVMAPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1P6</accession>
    <name>A0A2Z5R1P6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_10900</name>
        <name evidence="1" type="ORF">RA11412_2135</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88434">
        <property type="protein sequence ID" value="BAV88434"/>
        <property type="gene ID" value="RA11412_2135"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2135"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="57" mass="6289" checksum="4038E5722F85A39C" modified="2018-10-10" version="1">MPVDFRGGVITYDNLLWALEDPQIPAEELDLVEDLLQVSYGDGKYLLDVGWYSAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1W1</accession>
    <name>A0A2Z5R1W1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipolytic enzyme G-D-S-L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88560">
        <property type="protein sequence ID" value="BAV88560"/>
        <property type="gene ID" value="RA11412_2261"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2261"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="77" mass="8149" checksum="97FAD20B5DC3C452" modified="2018-10-10" version="1">MEQRNIRLVAVGDDLLAGVGDPRTLGWFGRVMARTPHNNASITAYNLAAPTKAVICSMNAGLKRHAAASHPVPITVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1W6</accession>
    <name>A0A2Z5R1W6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_2384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88683">
        <property type="protein sequence ID" value="BAV88683"/>
        <property type="gene ID" value="RA11412_2384"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2384"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="9">
        <location>
            <begin position="36"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="370" mass="40504" checksum="D4C78472A66F7CE0" modified="2018-10-10" version="1">MHGWGASGGLLFKVLPLNLPYPVRTGVPERINMKILVTGGAGYIGSHTVLELLNAGHEVVVMDNLSNSSETSLQRVAELAGRAPEFHNVDLLDLAGMKELFTSTQPDAVIHFAGLKAVGESAEKPLWYYQTNVAGTLNLLYAMEEANCRSIVFSSSATVYGEPESMPLVEKLNMDAQSCYGRTKEHIEDMLVDLAASDDRWNIALLRYFNPVGAHESGRIGEDPSGIPNNLVPFIAQVAVGRREHLNVFGNDYPTVDGTGVRDYIHVVDLADGHLKAVDYITEHGGLHTWNLGTGNGYSVLEVLHAFEKACGKELPYKIVARRPGDVAVSYADPSSALADLGWSASRDIDTMVRDHWNWQKNNPNGYEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1W7</accession>
    <name>A0A2Z5R1W7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydrolipoamide acyltransferase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88534">
        <property type="protein sequence ID" value="BAV88534"/>
        <property type="gene ID" value="RA11412_2235"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2235"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="2">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="73" mass="7643" checksum="8BDCC139016EA059" modified="2018-10-10" version="1">MSHTVELPALGESVTEGTVTRWLVAVGDTIAVDEPLVEVSTDKVDTEVPSPVAGVVEQILVEEDEDVEVGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1W9</accession>
    <name>A0A2Z5R1W9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RA11412_2172</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88471">
        <property type="protein sequence ID" value="BAV88471"/>
        <property type="gene ID" value="RA11412_2172"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2172"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="12">
        <location>
            <begin position="106"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV88471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="201" mass="20256" checksum="3C5353FE1410AF99" modified="2018-10-10" version="1">MGRTRFGDMVVLRAINLLTRARAYTLEGNNVTMSDTTESCGCSRTTQQTAGTALNEGTISRRNALIAGVAGGTGAVALSACGEGGSSRGSGNNNSSAGGQGPSEPTDMGAAADVPAGKAAKLTAGKVTAIVSQPQEGTFKAFSSTCTHQGCQVNVQGGAKIVCPCHNSQFSLSDGAAQGGPAEKPLESYKVEVKNGRIWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1X0</accession>
    <name>A0A2Z5R1X0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88476">
        <property type="protein sequence ID" value="BAV88476"/>
        <property type="gene ID" value="RA11412_2177"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2177"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="48" mass="5560" checksum="7FC153416F3D1855" modified="2018-10-10" version="1">MGDLAKRKISLFFTPENRSNAKPEYGVRPSLRSPYRRVRQGMCFWAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R203</accession>
    <name>A0A2Z5R203_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oligo-1,6-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88787">
        <property type="protein sequence ID" value="BAV88787"/>
        <property type="gene ID" value="RA11412_2488"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2488"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="193" mass="21697" checksum="FF6F003104401182" modified="2018-10-10" version="1">MVESQRVSPEDMLRYISASGRDNARTPMQWDASDNAGFTTGTPWLKVNPQYTDINAAEELANDDSIFYHYSDLIHLRKEHPIVLTGEYRVLDPEDEQVYAYLRVNSTEDAAASGERALLVVANFTQETLSLPYADGQLASLALKNPGVLKLEELAAMAEAPELISSNYRNEHGEFTDEGTTLRPYEAKVYLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R225</accession>
    <name>A0A2Z5R225_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09645</name>
        <name evidence="2" type="ORF">RA11412_2444</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88743">
        <property type="protein sequence ID" value="BAV88743"/>
        <property type="gene ID" value="RA11412_2444"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2444"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="50" mass="5526" checksum="3F0EF2D4E344E838" modified="2018-10-10" version="1">MANGKTIEVHHGPIDPKLAAAKKREREAKSTNDRKVTSTQPTQRDDAQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R245</accession>
    <name>A0A2Z5R245_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage shock protein A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Phage shock protein A homolog</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">PspA/IM30 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_10170</name>
        <name evidence="5" type="ORF">NCTC10207_01566</name>
        <name evidence="3" type="ORF">RA11412_2315</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023134061.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88614">
        <property type="protein sequence ID" value="BAV88614"/>
        <property type="gene ID" value="RA11412_2315"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2315"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI23472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="244" mass="26624" checksum="1D03DA0E380E2DE4" modified="2018-10-10" version="1">MVKQSIFGRIAQLAKANINALLDAAEDPQKMLDQMVRDYTNNIAEAEAAVAQTIGNLRMLEQDHAEDVRDAAEWGSKALAASNKADEFRAAGDAANADKFDNLAKIALGKQMQAEKEAKTAEPQIAAQTEVVEKLKDGLTKMRAKLDELKAKRDELNARQKTAAAQTQVNDALKAFDVMDPTSEVSRFEEKVRREEARVIGQQELAASSLDAQFNDLEELGRQTELEARLAALKNKGNGGAIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R252</accession>
    <name>A0A2Z5R252_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional repressor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Zinc uptake regulation protein ZUR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_10460</name>
        <name evidence="3" type="ORF">RA11412_2252</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887361.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88551">
        <property type="protein sequence ID" value="BAV88551"/>
        <property type="gene ID" value="RA11412_2252"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2252"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="155" mass="17601" checksum="DDEB944135F398F8" modified="2018-10-10" version="1">MDTHIPVRKIVKHAEARNTRQRRVIKATMAELGDFISAQDLHLILANRKEQVSLATTYRVLQSLANTGELDVIKGVEGESLYRHCQADTHHHHLLCRRCGKAVELEAPAIEEWALSMGKKYGFSELEHVVEVTGYCPDCTIERRKNESLVTVEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2B4</accession>
    <name>A0A2Z5R2B4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88674">
        <property type="protein sequence ID" value="BAV88674"/>
        <property type="gene ID" value="RA11412_2375"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2375"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010406">
        <property type="entry name" value="DUF1003"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41386">
        <property type="entry name" value="PTHR41386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06210">
        <property type="entry name" value="DUF1003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="201" mass="22999" checksum="450E4B13A93ED01B" modified="2018-10-10" version="1">MRRFTYSPNPDAFGRMTEGFARYMGTPQFLLWMTVFCGVWLGWNTLAPEELQFDPRSLNFTLLTLMLSLQASYAAPLLLLAQNRQDDRDRVVASEDRKRDQQNLEETQYLTREIASLRIALREVATRDFVRSELRDILEELKSIQEEQERQAEQLHDIGEEYEDEDTHEDGAQQGSESSDSAAAGDAAASAADKKERKDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2D2</accession>
    <name>A0A2Z5R2D2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dicarboxylate transporter/tellurite-resistance protein TehA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Tellurite resistance protein TehA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tehA</name>
        <name evidence="7" type="ORF">I6I94_08900</name>
        <name evidence="6" type="ORF">RA11412_2618</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88917">
        <property type="protein sequence ID" value="BAV88917"/>
        <property type="gene ID" value="RA11412_2618"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2618"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09324">
        <property type="entry name" value="TDT_TehA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039264">
        <property type="entry name" value="TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="327" mass="34671" checksum="CFE2FF41D772DBC0" modified="2018-10-10" version="1">MSTAAAQPVPLGTPTTTKPFPIPTSYFSVALGTSALGLSWRYGATAHLVPSWVGESILALASATWLVLITAFAVKLITRRDALQNELRDLVMCCFLALVPVTTIEIGISARPYAAPLGYSLILIGVLGQLAFSMYRTAGLWRGTHTVAATTPVIYLPTVAANFASASGLGALGHHDWAMLFFGMGLLSWFSVEAAILGRLRTKPALDPAVRGIIGVQLAPPFVGGNAYLAANGGHVDWVFLALTGYGVLQLLFLLRLVPWILKAGYTMSLWGFSFGLGAMAGAGMHLVAVSQLVQLGWALWILGTALIAVLWLGMLVLAIRGKLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2D4</accession>
    <name>A0A2Z5R2D4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_2337</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88636">
        <property type="protein sequence ID" value="BAV88636"/>
        <property type="gene ID" value="RA11412_2337"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2337"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="346"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="889" mass="97028" checksum="284F36D04D37762B" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2F2</accession>
    <name>A0A2Z5R2F2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_09820</name>
        <name evidence="3" type="ORF">RA11412_2405</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88704">
        <property type="protein sequence ID" value="BAV88704"/>
        <property type="gene ID" value="RA11412_2405"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2405"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340107" evidence="2">
        <location>
            <begin position="32"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="82" mass="8442" checksum="20C6795D8972B2B2" modified="2018-10-10" version="1">MKKNTSPFVIGAGAVAVLSLTGAVFATGALAASTPDEQPLPNYTWAVPSDAPTRDPLPSYNPEAAATDTPSEHAEVHPTEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2M7</accession>
    <name>A0A2Z5R2M7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89015">
        <property type="protein sequence ID" value="BAV89015"/>
        <property type="gene ID" value="RA11412_2716"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2716"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="156" mass="16349" checksum="04340A97EF33A9CE" modified="2018-10-10" version="1">MSAYGGETNFTNSLYQSHVHAANSTYNAPVLATGCLYRGRADFSGSSFTEGADFSTAAYDDGITLTGSTFAGPAVFTSCRFMGDADFTDCTCTTSANFSGTIYWDNAHFDRTVFATAPVFTRARFTPDAAMTSVEALSAGAPLTMGEGSCRPVPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2R1</accession>
    <name>A0A2Z5R2R1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I restriction-modification system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="162538">
        <property type="entry name" value="Rae11412ORF2447P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88746">
        <property type="protein sequence ID" value="BAV88746"/>
        <property type="gene ID" value="RA11412_2447"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2447"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
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    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="246"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="601" mass="67272" checksum="CFD205CE5577CB66" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2T1</accession>
    <name>A0A2Z5R2T1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Duplicated ATPase component YkoD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89038">
        <property type="protein sequence ID" value="BAV89038"/>
        <property type="gene ID" value="RA11412_2739"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2739"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV89038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="333" mass="35304" checksum="E745C77D14C9A286" modified="2018-10-10" version="1">MNTTTVGQHRTAEPAGSAGARIELDGFGWHHPGREKPAFSGITLSIEPGQKVLLLGPSGAGKSTLLHALAGVIHDDDGHSQLGTARIDGHTPADARGIVGLMQQDPESSVVLARVGDDVAFGPENLCIPREEIWERVSQALSAVNLEHLSLDHPTSALSGGQKQRLGLAGILAMHPRAILLDEPTANLDPQGVQQVREAVVRAAAHTGATLIVVEHRVSVWAQHMDRVIVLGSGGGITHDGPPEQVLDEARETLIADGVWVPGYVPETPGTPTAPKAELLSAENLAITREYPTKKQLRARRKQLKTMPDAAPVRISMPTLRGGVNLSIRQGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Y0</accession>
    <name>A0A2Z5R2Y0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="2">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_2512</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88811">
        <property type="protein sequence ID" value="BAV88811"/>
        <property type="gene ID" value="RA11412_2512"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2512"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="28"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="318" mass="33014" checksum="5F7013A7CD6ED86E" modified="2018-10-10" version="1">MTATEPLVLGIESSCDETGIGIVRGSKLLTNTISSSMEEHVRFGGVIPEIASRAHLEAMLPALEKALTEAGVNLSDIDAIAVTAGPGLAGALMVGVAAAKALAVATGKPLYGINHLVAHVGVGLLDDNGTSDGVRLLQNAEAGGLGALLVSGGHTEILQVRDITSDVRLLGATLDDAAGEAYDKVARLLGLDYPGGPAIDRAAKDGDRTAFTFPRGLSARKFMGSAEEPGQHRYDFSFSGLKTAVARVVEGLTARGEMVPVADIAASFQEAVVDVITKKQHLPAPSRGWILCCWAGAWRRIRGCGSCWRHGALLRGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R311</accession>
    <name>A0A2Z5R311_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89093">
        <property type="protein sequence ID" value="BAV89093"/>
        <property type="gene ID" value="RA11412_2794"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2794"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="49" mass="5217" checksum="F8FF1A8542E5991A" modified="2018-10-10" version="1">MSKAGNSSGHLADCCHVSLLMVDFYDGYAVDVTRKRPVTNVEAPGYSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R332</accession>
    <name>A0A2Z5R332_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_09045</name>
        <name evidence="1" type="ORF">RA11412_2587</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88886">
        <property type="protein sequence ID" value="BAV88886"/>
        <property type="gene ID" value="RA11412_2587"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2587"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="173" mass="19877" checksum="FD9E9332180CFA07" modified="2018-10-10" version="1">MKPESTPEPETINFTYDTDKELYVSDPVDVPALKKNAVTFRFDLQTLDSAGWQRIRAAIDNFRSPDADIFAQATPYVHQFYRMYFDMADEYGWEQYLPDIPESQVWSLVGPIWDQCTVALDNNSLLIVVEAETEWDIEHGMIMVYQDGVKLVKVGMAVESYTNPDGTIFDYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R346</accession>
    <name>A0A2Z5R346_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative metallo-beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89000">
        <property type="protein sequence ID" value="BAV89000"/>
        <property type="gene ID" value="RA11412_2701"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2701"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="133" mass="14567" checksum="8C8431C84D8A290B" modified="2018-10-10" version="1">MVNTHAHYERFFGNDVFVAMGVEDFWAHPRTVRAIEKYGESQRPYVETLEPEMAHHQGPATDIIVPNKLTAHNGEGITFTPVELGERSATLIYLGQGHTKGDLLVGVEDVLFAGGLLEQGTDPPLTIRTPTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R350</accession>
    <name>A0A2Z5R350_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_2695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88994">
        <property type="protein sequence ID" value="BAV88994"/>
        <property type="gene ID" value="RA11412_2695"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2695"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070204">
        <property type="term" value="F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004433">
        <property type="entry name" value="MenaQ_synth_MenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916">
        <property type="entry name" value="PTHR42916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="3">
        <location>
            <begin position="16"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="239" mass="25478" checksum="0C2BF3C6E95D607D" modified="2018-10-10" version="1">MTENRTPLSMLSAISVLDSLIRAGMRHIVLSPGSRSAPLAYAVAAAETAGAIVAHVRVDERTAGFTALGIAKASGRPVGLVCTSGTALGEYVPAVMEAYHTGVPLAIISADRPEKLRGTGANQTTFQHNLYGRFVRASADLTRYPEQSEGEQTQAFKRCLAALTGRDAHNWSRASDEPLGPAHINLCLDSPLVPDEQTARILPQWAASLTEHTDYAAEARQLAEHLGTAPMRALALSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R386</accession>
    <name>A0A2Z5R386_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menG</name>
        <name evidence="6" type="ORF">RA11412_2682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88981">
        <property type="protein sequence ID" value="BAV88981"/>
        <property type="gene ID" value="RA11412_2682"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2682"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="278" mass="30593" checksum="126FEA1E6BAE9864" modified="2018-10-10" version="1">MKTPPHPTHPASLQKVSNYPPAVEHATIEGVSTTEKNPMPRNSARSRASLDKKTGDIAAMFDTVAHRYDLMNGILSLGQHLRWRKHTVAAVEAHPGQKILDVAAGTGTSSEPFADAGVDVIAADLSEGMLEVGRKRRPDMTFVQADVTNLPFSDSTFDAVTMSYGLRNVADYPKALRELYRVTKPGGRIVVLEFSTPTFAPFGKVYKKYIMQAIPPVARAISSNPESYEYLAESIIAWPNQRDLAQEFARAGWRDVKYRNLSGGIVAIHRGFKLAEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3D0</accession>
    <name>A0A2Z5R3D0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dyp-type peroxidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Iron-dependent peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_08270</name>
        <name evidence="5" type="ORF">RA11412_2772</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89071">
        <property type="protein sequence ID" value="BAV89071"/>
        <property type="gene ID" value="RA11412_2772"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2772"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV89071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="451" mass="48247" checksum="3FFFA8F0F7F59278" modified="2018-10-10" version="1">MPPENPHKTTDTAGQTPLGAMRRRTVITGAAGVGVGAVAGASAHALLSPPRSDMSVPGRKPADIALTDATAGFYGEHQQGIATESQAHARFIAIDLNENLHAEAIQRLLRILTNDAAALTRGTAPLTDQEPELAQVSANLTVTIGFGSRIFDIAAPEKKPGWLAPLPAFPAIDKLQDAYTGGDLLLQLCCDDLTVLSHAQRMLTKDTRSFGRIRWVQNGFLRAFGAGTGTPRNLFGQVDGTVNPTADPAATPGRGGASLDDIVWGKGSASAGYPQAWEPGGTSVVIRRIHMNLDTWDEVDTPAREDAIGRKLSNGAPLTGTKEFDDPDFAKTNNLGFEMIAPYAHIRRARGEELDKKPWERILRRAYNYDEPVANAGGLSRHGEVSGGISNAGLIFVAYQTDPVQQFVPIQKRLEKLDMLNTWTIPIGSAVFAIPAGVREEGGYIGESLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3Q6</accession>
    <name>A0A2Z5R3Q6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formaldehyde dehydrogenase MscR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87819">
        <property type="protein sequence ID" value="BAV87819"/>
        <property type="gene ID" value="RA11412_1520"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1520"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="1">
        <location>
            <begin position="29"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="165" mass="17135" checksum="425F74538A379525" modified="2018-10-10" version="1">MHKVKAVVALAKNEPVTVTTINVPDPGQGEALVKVLTCGVCQTDHHYVAGGVGDEFPYLLGHESAAVVEAVGEDVTDIAPGDLVILNWRAVCGECRACRKGEPQYCFATHNATQKMTLEDGTELTPALGIGSFAEKTLVAAGQCTKITADISPNSTPLLGCSGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3T7</accession>
    <name>A0A2Z5R3T7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87979">
        <property type="protein sequence ID" value="BAV87979"/>
        <property type="gene ID" value="RA11412_1680"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1680"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="42" mass="4626" checksum="B0A9BEF2A5D0D24E" modified="2018-10-10" version="1">MYPLSHLPDVLFCVSHDSLGGGLVLMLPFPVFPVMNLVQVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R496</accession>
    <name>A0A2Z5R496_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_11030</name>
        <name evidence="3" type="ORF">RA11412_2100</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037235180.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88399">
        <property type="protein sequence ID" value="BAV88399"/>
        <property type="gene ID" value="RA11412_2100"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2100"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="54"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="284" mass="30834" checksum="1A0CD0514C4A4332" modified="2018-10-10" version="1">MSGQQGKKALPTIAPSTSGDRLFRVLGTMVRPTYHAIASIKIEGRENLPQKGGYIVVANHTTEVDPITVAYAPFISGALPRFLAKDSLFRAPVLGWLMCKMAHIPVIRGSVDARKSLITARSVVEAGGAVVIFPEGTTTHDPDTWPMQARTGAARLALATGAPVIPVAHWGDEQILSYEYVDGPDGKKKEKRKVSLWPRKTVHVKIGQPMNIAALVDDPSPQAKRTRTELNIVTEAMMDEITALLAHIRGEQAPKGRWNPKTKRRELPGETTGVTGTLGEPDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4C1</accession>
    <name>A0A2Z5R4C1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_2180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88479">
        <property type="protein sequence ID" value="BAV88479"/>
        <property type="gene ID" value="RA11412_2180"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2180"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="194" mass="21290" checksum="AD156377ED231F3E" modified="2018-10-10" version="1">MLMIVITGVLLVSILYLARQSGVQLVQNPNRYLSADPSSPNQPIHQKPALYQVAFAVYGNDLIPTLLALATVSVLVIASLTAFIGFPIGASAIADRHYLPHRLRSVDSTGLYSNGVILLGVISVLFTVLFAADVFALIQLYVVGMCTSMLLTQVAVVRFRLRKLRITLKPSARRKLARDITVSAVGWWSPPWCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4K7</accession>
    <name>A0A2Z5R4K7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88629">
        <property type="protein sequence ID" value="BAV88629"/>
        <property type="gene ID" value="RA11412_2330"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2330"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="23"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="311" mass="34779" checksum="D0794CCCAC7DFEB1" modified="2018-10-10" version="1">MPGIYPVATAAAPEESAEYDTAVITDSADRNWRVRAPRNHDASMRLEAEHQVLRSFTHGLRARLPFTVPTIAGTVPYNGMSVFVYTYVPGTHRDLDELARINRANNSTLATDLGRLIATLHVMPEDIMIESDLPVYSSQNLRRRKLSELDRAASTRKVPAELVAHWRAFLEPGPIWDFRTRVVHGKLGTETISIHNGTVAEVSGWSEVHVGDPAQDLSWLFACSDTAFTDEVVRVYSSQMPQMPDQHLVERAEFYAEFALAQWLTHAVEYGDAQMIAHGEQMLQAVCENLRDSGDMLGQNQPLPERAEGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4L0</accession>
    <name>A0A2Z5R4L0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ThrE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88639">
        <property type="protein sequence ID" value="BAV88639"/>
        <property type="gene ID" value="RA11412_2340"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2340"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="2">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="143" mass="15568" checksum="3717183C09B7CEAD" modified="2018-10-10" version="1">MKRGVSHMAIWMACGFLSAGAYIGLINLLTGLQLIGSEHMVGFISSILFLVPGFPMVTGMLDISRMDLLAGMSRLMYVTVLLVSASFAVWVLASLFHLPLAQNARPDIPDGLYLLLQVVSSGLLRRALRCCSRRPRWRACGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QV99</accession>
    <name>A0A2Z5QV99_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Osmosensitive K+ channel histidine kinase KdpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86310">
        <property type="protein sequence ID" value="BAV86310"/>
        <property type="gene ID" value="RA11412_0011"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0011"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="75" mass="7901" checksum="D047EB18E26DC283" modified="2018-10-10" version="1">MTDQGAGIPEEEQARIFERFYRVDAARSRQTGGTGLGLSIVKHVMGQHGGQVSVQSVPGQGSTFTLSLPIADTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVE5</accession>
    <name>A0A2Z5QVE5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_07900</name>
        <name evidence="8" type="ORF">RA11412_0064</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 11">FDAARGOS_1137</strain>
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    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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    </feature>
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            <begin position="37"/>
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        </location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVF0</accession>
    <name>A0A2Z5QVF0_9MICC</name>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">JCM 11412</strain>
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    </dbReference>
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            <dbReference type="EMBL" id="BAV86360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
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    </evidence>
    <sequence length="96" mass="10873" checksum="339B5F26389D2232" modified="2018-10-10" version="1">MYRWLFFELEDGFAVFSSNDGDIEVELADEITCLFDIEEGDIFTLMHITNEDLGVIHSVECQRDALGNLIEVTICTHKKNITLNSLTLEGFEISIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
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    <name>A0A2Z5QVG1_9MICC</name>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="BAV86356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="40" mass="3870" checksum="A209320C5EDBD61A" modified="2018-10-10" version="1">MGSCAAVLTCGDALATEALAEALALALLEAADELGLSCAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVH6</accession>
    <name>A0A2Z5QVH6_9MICC</name>
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        <recommendedName>
            <fullName evidence="3">Excalibur domain-containing protein</fullName>
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    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="BAV86395">
        <property type="protein sequence ID" value="BAV86395"/>
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    <dbReference type="KEGG" id="raj:RA11412_0096"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="318" mass="31633" checksum="99F9247388ABEAEF" modified="2018-10-10" version="1">MTVVLRGDEGEIYHEVRPDANGKFTTSIPWSNSLQAGQSIEFETFALTRGGFYEGSEVDVRVVAAPARQNPAPQPKTTTGAAQKPAEKDKSGENKNGGGSDGGSTSGDKNNKDGNGGSGDNKNQGGSGGDNNSGGNNNNAGGAQSGGGSDPSASPQGGQQDSNGASGSAIDSSEPDGPSDKVSASASESSPSASASASASGNKRFHNCKEVKDAGLAPIHKDHPDFQEGFDADHDGVGCDKPADFGNEPVTITTGAAAGDSSASTEASGEQGSSGQGFSPADLADPGKNGVLLAAGYVLIVGGIGGAIFLAVRKMRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVL1</accession>
    <name>A0A2Z5QVL1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">RA11412_0121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86420">
        <property type="protein sequence ID" value="BAV86420"/>
        <property type="gene ID" value="RA11412_0121"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0121"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="89" mass="9532" checksum="BE18E139D4E66978" modified="2018-10-10" version="1">MYEDEEPQFDADTETPETGGKSRKARRSARKAQNRKNLNRQRAGGQKASQGDSAPQQDAPQKSGGRKGSGRGSGGRKRAKTSAARNSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVL5</accession>
    <name>A0A2Z5QVL5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86421">
        <property type="protein sequence ID" value="BAV86421"/>
        <property type="gene ID" value="RA11412_0122"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0122"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="101" mass="11145" checksum="DF4172A5E1E44628" modified="2018-10-10" version="1">MSEQVIDQNPTETASFDPFADHTYEQVGEPTLGQPHKRRRTSRVDTVLAQAKDVALAGIEQIAPKNTIGLLHHLRGEEDRLTTHLFECTLPGYRGGSGSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVM4</accession>
    <name>A0A2Z5QVM4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">23S rRNA (Uracil(747)-C(5))-methyltransferase RlmC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rlmC</name>
        <name evidence="7" type="ORF">I6I94_07585</name>
        <name evidence="6" type="ORF">RA11412_0148</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86447">
        <property type="protein sequence ID" value="BAV86447"/>
        <property type="gene ID" value="RA11412_0148"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0148"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016436">
        <property type="term" value="F:rRNA (uridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011825">
        <property type="entry name" value="23SrRNA_MeTrfase_RlmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02085">
        <property type="entry name" value="meth_trns_rumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="376" mass="41958" checksum="9243C3ED47D3FE74" modified="2018-10-10" version="1">MECAYYRESLCRSCTSIETPYPAQLAAKQADARRLLAAYPHLTWLEPVASAEAHFRNKAKLVVGGSAQNPSLGIVDYRSGRATDLSECPLYIKPIERAIPVLHELIQRADLTPYDIPARRGELKNILVTASETGELMVRFVLRSKKLLVPIRRQLGWLQERLPKLAVLSVNLLREHVALIEGDEEIILTERQTLPMRVNGMSLHLRPQSFFQTNTQIAQAMYAQGREWVGQAQPRTLWDLYCGVGGFALHAAQVMHGEVTGIEISAEAIRSAQRTVAEQGLKGVKFAAGDATEFAVNARETPEMLVVNPPRRGIGERLCAWVEGSRIEHVIYSSCNAKTLAADLARMPSYKPVAARVLDMFPHTNHYEVMVLLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVQ7</accession>
    <name>A0A2Z5QVQ7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_0167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86466">
        <property type="protein sequence ID" value="BAV86466"/>
        <property type="gene ID" value="RA11412_0167"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0167"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="113" mass="12699" checksum="26E42F3838B523EE" modified="2018-10-10" version="1">MFAEERRAEIAKLVASARRVNGAELARRYDVTMETVRRDLAALEEAGKLRRVHGGAVTVEQSTSLESSIASRQGMNTPRSGVSPLKRTTCSATPRWALLCWTRAQPLRFWQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVT5</accession>
    <name>A0A2Z5QVT5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07335</name>
        <name evidence="2" type="ORF">RA11412_0216</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86515">
        <property type="protein sequence ID" value="BAV86515"/>
        <property type="gene ID" value="RA11412_0216"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0216"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="121" mass="12644" checksum="A2E42EFC38DFE39B" modified="2018-10-10" version="1">MSETMTLAPSSSADEQTFRYSSQLGPHTYSVPVVPQIPNPEAEAAVKKIKLFSTAALIVGVLGLFFYLYVGFIGAAAIGAGVVALTLNKGYESRGLAIAGILLGAAGISMWAFSLYMSSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW48</accession>
    <name>A0A2Z5QW48_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6318 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86637">
        <property type="protein sequence ID" value="BAV86637"/>
        <property type="gene ID" value="RA11412_0338"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0338"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046281">
        <property type="entry name" value="DUF6318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19843">
        <property type="entry name" value="DUF6318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6318" evidence="2">
        <location>
            <begin position="11"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="175" mass="19573" checksum="DD142E86FC41BFF0" modified="2018-10-10" version="1">MKLESYDTSAGTYSPATRTQPAKNVPKPIKPKNMNENSEEGFYSSLAFMAASMQYLMTTGDSQYTEQVKLHPEEKKNYDIMVEQYSVLQTGEVWFEDPKYVITLETSSSNKSGKYYLWPATITTAVGTYLVTAGQVRDMPANERKISSKVVMRGEYTGGVWELAGIQAFSSTVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW66</accession>
    <name>A0A2Z5QW66_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06755</name>
        <name evidence="2" type="ORF">RA11412_0332</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86631">
        <property type="protein sequence ID" value="BAV86631"/>
        <property type="gene ID" value="RA11412_0332"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0332"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="265" mass="27336" checksum="07EC9D3A4963ABBF" modified="2018-10-10" version="1">MSRYSFLTAYLADPAPQNTRDHGGSAPATTGSAAAHAPQRTAPAATQNTRHSSPTPAAQPGGGGRRVQAPSVVKPGGSNSEGQQVAPPDMRKPARRTATYTPAEPNSQISGAPSGAETTETSTTVTASPTPDPEPHWWGSAPNITEAAQEERAFILDAVQSGIGGVSITGTNLHATLLTWDGATIDYPEPSRPEPIDTVTRITLNTDCTVLSIPPRALTQLRSLVVGGENLILANTSLGFTRTLGRGALVLSESGYATLAIAIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW83</accession>
    <name>A0A2Z5QW83_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RHS repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_07055</name>
        <name evidence="1" type="ORF">RA11412_0255</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86554">
        <property type="protein sequence ID" value="BAV86554"/>
        <property type="gene ID" value="RA11412_0255"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0255"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="192" mass="21415" checksum="6F52FB7E30370C3F" modified="2018-10-10" version="1">MRYTRSFCFSDDIYQIASPEGNVIAITAPDGSSTQIGYHETLNLPVAVNDPAGRITAYTYDERGNLISITDPAGYTTRYGYNAQWLPETITDALGKTRHLHYDTLDQLVCFTDCTGETTRFGYTEYGDLETVTDALGHTTRHHYDAAGNPVRTDYPDGSHETFEYDRLNRLTAYIDGLGAKTAYELANAKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWH0</accession>
    <name>A0A2Z5QWH0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86767">
        <property type="protein sequence ID" value="BAV86767"/>
        <property type="gene ID" value="RA11412_0468"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0468"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="4"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="207" mass="22540" checksum="D590499BA4B638D3" modified="2018-10-10" version="1">MHLAKTVILSTGSEYRKLGVEGEDRLSGYGVSWCATCDGFFFKEKDIAVVGGGDSALEEALFLTTFARKVYIIHRRDSFRASDIMQKRAFENPKIEVLWDSEVSAIDGDSNLEKVTLKNTKDGSERELPLNGLFIAIGSDPRVDMVKDQLTLSEQGTIEVQGRSSKTSVPGVFAAGDVIDPTYRQAIIAAGSGAVAALDAQHYIENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWI7</accession>
    <name>A0A2Z5QWI7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86740">
        <property type="protein sequence ID" value="BAV86740"/>
        <property type="gene ID" value="RA11412_0441"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0441"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="264" mass="29447" checksum="92F06388DA8A7EFC" modified="2018-10-10" version="1">MKRFTTDHLTTFAAVIEHGTFDAAAEALRVSPSAISQRIKVMEQLAGKVLLRRTNPVTPTQAGQSVLRIARQSEFLQLELERELVGEGGFQAVSIALNADSLATWFLEAVRMLAHEDEIFCDLRREGEFHSSALLRSGEVMAAITSRPGKIPGCSVDYLGVARYWCVAAPEYMSRYLPGFPSATTREELNRAPVVEYDRKDFVQEAARVLIEEDMKLPPSLEPEQSPTIYIPSSPDYARAVYEGLPGDCYRKLSAVNILPPIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWK6</accession>
    <name>A0A2Z5QWK6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-ribbon-containing possibly RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86782">
        <property type="protein sequence ID" value="BAV86782"/>
        <property type="gene ID" value="RA11412_0483"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0483"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="85" mass="9089" checksum="DF2CE430627734FB" modified="2018-10-10" version="1">MDEVDAPAALLERMRAAANARGEGRLNAYSAKKIMREFGAAMSAEPGQRKKSQRAQGWDPRVMGGYTGPGESTRDPKPLGVLLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWN3</accession>
    <name>A0A2Z5QWN3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_06290</name>
        <name evidence="1" type="ORF">RA11412_0444</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86743">
        <property type="protein sequence ID" value="BAV86743"/>
        <property type="gene ID" value="RA11412_0444"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0444"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="401" mass="43759" checksum="8A9F9EDBE14F22E4" modified="2018-10-10" version="1">MSRILFSPESFNMGETTRGIEIARAAVKHGHEVLFHVYSPRHLKLIEDAQLPVCLSEPLMSEAEADQLMALDQGRGVRHPFTTEKVRRRVAAELVAIRTFKADAVVIGSNLTMLISARVAGVPLFYARPYAYSTTYFSAAPERERAAAPGWVRALAQVISYKPASFTAVAREYGLKLPRRTVDMLSADVNLICSLFTELRGDPLRAPDVSVGPIFYRAPGGLPPIVREPKKRPLIYVGMGSSGSAHILAAVLRQLSSAPVDVLLGGGMLLSDVDARSLGHNIHRAGTVPAHLLAGHIDASITHGGEGTVQTACLAGVPFAGIAMQAEQRWNIEECVQYGNALRFTKHDVHRGQMRDILNRLLSDEAMRAKARQLGEAMRGMDGSTCAVEVIEDYLRNRHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWN5</accession>
    <name>A0A2Z5QWN5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurium resistance protein TerD</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TerD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06740</name>
        <name evidence="2" type="ORF">RA11412_0335</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86634">
        <property type="protein sequence ID" value="BAV86634"/>
        <property type="gene ID" value="RA11412_0335"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0335"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="192" mass="20579" checksum="7AAB3D640B70B90E" modified="2018-10-10" version="1">MAINLSKGQKINLSKDSGLTQVRLGLGWDPIKVKGFFGRTKEKAVDLDASVLAYDASGQMVEAVFYGSLRAANGSIIHHGDNLTGAGDGDDEVIDINLPGVDARINTLALVITSYSGDQFSGIENAFVRVENVENRQELARFEMTQKGSHTGLMVASISRDGNDWVFKAVGSPLPGAARTPRDVIDPARAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWN6</accession>
    <name>A0A2Z5QWN6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86828">
        <property type="protein sequence ID" value="BAV86828"/>
        <property type="gene ID" value="RA11412_0529"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0529"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="68" mass="7518" checksum="52B7FF914DDD6605" modified="2018-10-10" version="1">MNTDGSWRQQAEHVTLYGTSDGKVYQQKPDMREVGPDRIPDETPAVPTIYGQDGVGIRASSRCARAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWQ1</accession>
    <name>A0A2Z5QWQ1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycopeptide antibiotics resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86857">
        <property type="protein sequence ID" value="BAV86857"/>
        <property type="gene ID" value="RA11412_0558"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0558"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="14"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="111" mass="12195" checksum="935A0E0FD7B639DD" modified="2018-10-10" version="1">MGLSRFTTGVFAQLFFNIAMFIPLGVLTAGCLRWGLRASTLAGFGLSLFIELSQLSGNWGLAPCPYRTFDVDDLINNTAGALMGALVVMLWRLLRSRLRARRAARVATANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWR9</accession>
    <name>A0A2Z5QWR9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86831">
        <property type="protein sequence ID" value="BAV86831"/>
        <property type="gene ID" value="RA11412_0532"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0532"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016247285" evidence="2">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="99" mass="10253" checksum="B326AE5944A10A04" modified="2018-10-10" version="1">MKKTSRNRMAAPVSASFALLLALSACSSSGVNQGGGANNSGSSESASAPTEDGRQIVGLGDDNKAGKPRPRSERETRGNQNQVKSDGSWTEKTLSGQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWY5</accession>
    <name>A0A2Z5QWY5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_05690</name>
        <name evidence="1" type="ORF">RA11412_0601</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86900">
        <property type="protein sequence ID" value="BAV86900"/>
        <property type="gene ID" value="RA11412_0601"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0601"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="132" mass="14457" checksum="95EC29B07D018519" modified="2018-10-10" version="1">MFDFFVKNRLSPQELAAFIAVALGCPAKNVLVVTSSELQGIPPVELNALRCLCLYWHVTGDAALLVSLYRVEASPEEIQEKVVAASRAAGVVCYVPNDNFNGYLLCGEAEPVQVYEDEAASSDEGLHHIFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWZ9</accession>
    <name>A0A2Z5QWZ9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0547</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86846">
        <property type="protein sequence ID" value="BAV86846"/>
        <property type="gene ID" value="RA11412_0547"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0547"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="109"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="186"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="418" mass="45152" checksum="99079250E2971362" modified="2018-10-10" version="1">MCFDRDGQTTFAGILDSKAHTQGISDSDKNLLSAIRLGAQDGVPVEVELESGGHYLVQVSKGKPGSGNLLVGVPMGDMHQTLAATITVMVIGSVAVMMLAGMLGSYIIRRTMRPLERVSAVATDVANLNLGEHTISQQVKVMPKDADPRTEVGAVGYALNQLLDNVSSALEVRERTEQQIRAFIADASHELRTPLAAIKGYSDMMRWTEAMSENGQSSLARIDSQTVRMSRLVEDLLLLARLDEGREPQFELIDLTELLIECLSDMQAAARTHVWRLDVPDEPVEMIADRSQLQQVILNLLSNARKHTDDGTTVIAGLRVSADRSHALMTVVDNGPGIDPQFVDKIFDRFARADKARSGSDGTTGLGLSIVQAIVRVHGGTISVKSRPGRTEFMVRLPLASAAPAQARLSVQKGTGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX00</accession>
    <name>A0A2Z5QX00_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)H-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Oxygen-insensitive NAD(P)H nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_05435</name>
        <name evidence="3" type="ORF">RA11412_0659</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86958">
        <property type="protein sequence ID" value="BAV86958"/>
        <property type="gene ID" value="RA11412_0659"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0659"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02149">
        <property type="entry name" value="NfsB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033878">
        <property type="entry name" value="NfsB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="219" mass="25080" checksum="CF3F86CA149EDE0C" modified="2018-10-10" version="1">MILTREQALEIFKRRVSTRSYDPARTISDEDFNTILEFGRLSPSSVGSEPWKFLVIQNKELREKLKPIAWGMANTLDDASHVVIIVAKKNARYDSDFLLQALAKRNLPEDQMQMALDRYKKFQVHDMKIADDERSLFEWTRKNTYIALANMLTGAAMLGIDSCPVEGMDYDVVTQLLTEEGLLDPEDYGVSVAATFGYRSREIDPKPRKPLDELVVWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX09</accession>
    <name>A0A2Z5QX09_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86856">
        <property type="protein sequence ID" value="BAV86856"/>
        <property type="gene ID" value="RA11412_0557"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0557"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="61" mass="6928" checksum="AD5230EB27AACBE6" modified="2018-10-10" version="1">MADSDGAVKVAHPKMHGDHPDRKKNEQGNTNFRSENSGHLLVKYEVSHTQPLIYLLEIFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX95</accession>
    <name>A0A2Z5QX95_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable conserved integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_0768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87067">
        <property type="protein sequence ID" value="BAV87067"/>
        <property type="gene ID" value="RA11412_0768"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0768"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="237" mass="26436" checksum="7E7DED7C07579E39" modified="2018-10-10" version="1">MRKEWKSIIALGVSFAGTIAAGFAVLPQQSLTYWGSVIWDPSRVGNPISSNSMAIQGVLGRMTFQDGTVLKALYGIAAIALIAVIGYALRKMEQHNLYLSQISLAILVPVFISPISWFHHAVILPIFMVCAAVDFLPLVARWRSRAGRILCYLCYALSSLMLINTLLDWGKLVVRFWRRVDFYPFTGRYPGMDAHTLLLRAADEQPVMFVTSIPALALVVLVVLWAVLLRRPAESRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXB6</accession>
    <name>A0A2Z5QXB6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86976">
        <property type="protein sequence ID" value="BAV86976"/>
        <property type="gene ID" value="RA11412_0677"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0677"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="38" mass="4413" checksum="4799E6C25BFB6763" modified="2018-10-10" version="1">MVGDHQLFYVATTDIVDAQQRILQRERDIDALLRVLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXD0</accession>
    <name>A0A2Z5QXD0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH LytTR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87098">
        <property type="protein sequence ID" value="BAV87098"/>
        <property type="gene ID" value="RA11412_0799"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0799"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="133" mass="15125" checksum="85BD67B82876AF85" modified="2018-10-10" version="1">MSIVYAQKDVRVSRIVDFVESVEQRIKCENGSTDIMVNASDIFYCESVKKTTFVHVAGNTYRTDHRLYDLAEKLQDCGFVRVSKSCILNINVLESVKPLFNSRMEAILTTGDKVYINRTYLKNVKQALKGYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXE9</accession>
    <name>A0A2Z5QXE9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DedA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87051">
        <property type="protein sequence ID" value="BAV87051"/>
        <property type="gene ID" value="RA11412_0752"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0752"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="107" mass="11281" checksum="56AC2B30D35746DD" modified="2018-10-10" version="1">MSLLASALVAHMPVALLGFNLEDILISTGPWVLVVSAIIVFIESGVLFPVLPGDSLIFALGMLHDRMGLSLWLAFPVLIVAAVAGGEVGTSWAPVTDVTCSRMTRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXF7</accession>
    <name>A0A2Z5QXF7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oligopeptide ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87128">
        <property type="protein sequence ID" value="BAV87128"/>
        <property type="gene ID" value="RA11412_0829"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0829"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016340161" evidence="1">
        <location>
            <begin position="34"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="131"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="318" mass="35239" checksum="775E93606BBEA19A" modified="2018-10-10" version="1">MQKQYIFNRRTLLGAAAATTTVGLLAACGGSKKEDKVKAPGKDAKSEELYNINSHPVSDLKQGGEVRIPLGSLGPDFNTYSTSGDSYDTQIVMSSIRAAGLWNITHLGKYELNKDFALSFKPVEEGGKDVVYIELNPKAKFNDGTPIDYKALQSTWKIRKSSDGDYNIISSGIYEYIESVENNGGNFKVKVTMAKPYYPLNEMFDAIFHPGMEDPKVFNDGFVNNPHPEFGCGPFKLADKGWNSTENTFTMVPNEKWWGEKPVLDRVIFRGLEESAKVAAFKNGEVDAVESRTSTSYAELKILRMLSCAKVSCCMRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXP8</accession>
    <name>A0A2Z5QXP8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanal monooxygenase alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87228">
        <property type="protein sequence ID" value="BAV87228"/>
        <property type="gene ID" value="RA11412_0929"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0929"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="164" mass="17854" checksum="5C5BC9A0C9FB580D" modified="2018-10-10" version="1">MNAHKTTPTLEHLQPAPGTSKKLGFLSFGHWAEIPGSRVNSASDSLHQAIDLAVGAEEIGLDGAFFRVHHFDQQQATPYPLLSAIAAKTSRIELGTGVIDMRYENPLYMAELAAMSDLISAGRLQLGVSRGSPESVIRGFESFGYYPPKVKMRVRWHAVTSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXQ6</accession>
    <name>A0A2Z5QXQ6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037235937.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87151">
        <property type="protein sequence ID" value="BAV87151"/>
        <property type="gene ID" value="RA11412_0852"/>
    </dbReference>
    <dbReference type="GeneID" id="32323535"/>
    <dbReference type="KEGG" id="raj:RA11412_0852"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="114" mass="12062" checksum="A261084ACCD62E7D" modified="2018-10-10" version="1">MPTVTFKKVYTAAVNAPYAPPLVVVVYVMAALAMFCAWVVMPNIWGLLVGQAVHGVMYAHMMVAIVTAEGAKNKSAELSSHLGTGQLLVVAMFLICAVAGVRRIRAVTVEKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXT1</accession>
    <name>A0A2Z5QXT1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_0966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87265">
        <property type="protein sequence ID" value="BAV87265"/>
        <property type="gene ID" value="RA11412_0966"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0966"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="172" mass="18086" checksum="D94F9C9CC9EFF9DD" modified="2018-10-10" version="1">MTRSGGFNLVDMNDIRPVTSLITDVLMFIGGGSASTAGGIKVTTIAVIMLAIMAEARGDQFVVAFNRTIPDTVLRIAISVTMMSAGIVVAGAGVILMLTDQPLSRVLFEVISAYATCGLSDGLSAELSPAGIYTLSALMFIGRIGTITAATALALRSRRRLYKFPEERPIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXU9</accession>
    <name>A0A2Z5QXU9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87285">
        <property type="protein sequence ID" value="BAV87285"/>
        <property type="gene ID" value="RA11412_0986"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0986"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="147" mass="16435" checksum="3F8B577F674B65B9" modified="2018-10-10" version="1">MGEYLIREHARQAGLEVEVASSAITDYEIGNPIDTRAGRILTARGIDPSGHRASRFVAEDFDRYDLILAMDTPHYLHLKQLARTEDDKAKIRMMRSFDPAMAGKNLNELGIYDPWYGQMRDFEYTTELIDTAARALIAGLAAEGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXV7</accession>
    <name>A0A2Z5QXV7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA (Guanine46-N7-)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87295">
        <property type="protein sequence ID" value="BAV87295"/>
        <property type="gene ID" value="RA11412_0996"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0996"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="119" mass="13973" checksum="E4514C5552255049" modified="2018-10-10" version="1">MLDENSVDELWVFFPDPWHKSRHHKRRLVSPAFADKVARVLKPGGIWRLATDWEEYAHVMRDVMEAHPDFENLHAGEGATEDDPVGGWAPRWEGRILTSFERKAREAGRRAHDLTYRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXW0</accession>
    <name>A0A2Z5QXW0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 17">Aspartokinase</fullName>
            <ecNumber evidence="7 17">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">I6I94_04605</name>
        <name evidence="20" type="ORF">RA11412_0851</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 23">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 18">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7 17"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888570.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87150">
        <property type="protein sequence ID" value="BAV87150"/>
        <property type="gene ID" value="RA11412_0851"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0851"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="12 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17 21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="277"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="BAV87150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QQT89880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="431" mass="45589" checksum="3765800A07C633C6" modified="2018-10-10" version="1">MSLIVQKFGGSSVADAESIKRVARRVANTRKAGHDVVVVVSAMGDTTDELLDLAAEVTSAVTPSRELDMLLTAGERISMAALAMAINDIGVQAKSFTGSQAGMITDGVHGAARLVEVKPDRIRESLEAGNIAIVAGFQGMNRQSRDITTLGRGGSDTTAVALAAALNADVCEIYSDVDGVFTADPRIVPTAHKLNTVTSEEMLEMAANGAKILHLRSVEYARRFNLKLHVRSSFSELEGTIVIPENSAELTPTHLKEIPLEQPLISGVAHDRGQAKITVVGVPDVPGSAARVFGLINEAKINIDMIVQNVSTDRPNVTDISFTLDQAHGPLALQALEKAQAEIGFEEVIYNEAVGKLSLVGAGMKTNPGVSFTFFEALSNAGVNVEMISTSEIRISVITELSKLDDAVRAVHTAFALDTEGEATVYGGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXX1</accession>
    <name>A0A2Z5QXX1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87160">
        <property type="protein sequence ID" value="BAV87160"/>
        <property type="gene ID" value="RA11412_0861"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0861"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="273" mass="29845" checksum="AEAFF8365C619FF7" modified="2018-10-10" version="1">MRAARRAGRMLEPALLSSSELVGYLPFTAHGRTLHYRVGNAHRLEGAGSSPGVLFFFDGDYLLRSGSRLLRRTSTLREELSDIAYQHRMLLVPVLAPGTVNEGVLREATTNWWVRARANGRVFRALAADLHERYGYDRSRVWLAGYSGGAEFIAYELLLHAADAMVGGGATLIGGGGADGIPTQHRAPNISLSRLLLSWHVGDKDGRSPRLLNDTRSGGLWSAQVAAQEGGQFYARLGARTALHVMPGQGHRNYPITQLVRNDLAMATRLGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXZ8</accession>
    <name>A0A2Z5QXZ8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MTS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87231">
        <property type="protein sequence ID" value="BAV87231"/>
        <property type="gene ID" value="RA11412_0932"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0932"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="176"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="591" mass="65634" checksum="E2B9DB88C97B8D06" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYD2</accession>
    <name>A0A2Z5QYD2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87320">
        <property type="protein sequence ID" value="BAV87320"/>
        <property type="gene ID" value="RA11412_1021"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1021"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016425068" evidence="2">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="113" mass="11678" checksum="1460144C50151475" modified="2018-10-10" version="1">MRNTRTKFLTSLSCFGALFTLVVSGCSSGASSTSTSASSSESSSASASASAAPIVESKGPSSRVAITYDGGVLVYDAKDMKLLQDIKKDGFLRLTPPGITVTSWLLMATVTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYE6</accession>
    <name>A0A2Z5QYE6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8" type="primary">purH</name>
        <name evidence="10" type="ORF">RA11412_1012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87311">
        <property type="protein sequence ID" value="BAV87311"/>
        <property type="gene ID" value="RA11412_1012"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1012"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="534" mass="57349" checksum="790675ACE80C03A6" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYG6</accession>
    <name>A0A2Z5QYG6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87284">
        <property type="protein sequence ID" value="BAV87284"/>
        <property type="gene ID" value="RA11412_0985"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0985"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="199" mass="21622" checksum="E2FA57CE4493EF96" modified="2018-10-10" version="1">MSDQFRGLTDDLLPRIVSGPRPYIIAVDGRSGSGKTTLARRLAATLRQHPAQGGPLTVLELSLENMYPGWDGLEAGVEQWVRLSASLAEHTPGSYTPWDWEQNRPASPVTVPPDAAPVIVCEGVGALCGAFNYGVLVQADTGVRYERAMARDGETYRPYWNMWAAQEEQLFEDYGSYYITSPGWAEGPTGCTAPGSEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYJ0</accession>
    <name>A0A2Z5QYJ0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87537">
        <property type="protein sequence ID" value="BAV87537"/>
        <property type="gene ID" value="RA11412_1238"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1238"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="3886" checksum="18DB417A4576F916" modified="2018-10-10" version="1">MKLLGKSLHLRSATDSFEGAGESIPAYCLLQALHAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYP6</accession>
    <name>A0A2Z5QYP6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate cyclase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Adenylate/guanylate cyclase domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">pH-sensitive adenylate cyclase Rv1264</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_03385</name>
        <name evidence="5" type="ORF">NCTC10207_00593</name>
        <name evidence="3" type="ORF">RA11412_1177</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888126.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87476">
        <property type="protein sequence ID" value="BAV87476"/>
        <property type="gene ID" value="RA11412_1177"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1177"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="209"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI22515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="376" mass="41937" checksum="8CB0358354B407C4" modified="2018-10-10" version="1">MVDRSASTSSLPVTHGPETQMLNLKILQNLSQSNIYRDEKSKEGVRSLEKTLLGEGPRYTHRQAALAAGMDPQKARKIWRNMGFSDTPAEEHYFSDRDVQLLRTIVELEREGEVTFESAQSIVRSVGQLTDRIVAWQIESLVDDIVAREGVSDAQARRTLLFKLPKLMPALEELAMYGYRRQMYSGVLRLALRENRDPGESHKLPLMRGVGFVDMVSYTSLVRSLDKGELSRLINHFEQSCLDVIVPRRGRIIKTLGDEAFFLTESPESAAEISCELVRSFDRDPQIPGVRVGFIWGEVLASRGDVYGSSVNLASRLVSIAEPGTALTDSVTADVLRESETYFRLTEQGTKNVRSFGNIGTVSVSLGSNNTMESTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYQ3</accession>
    <name>A0A2Z5QYQ3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_02955</name>
        <name evidence="2" type="ORF">RA11412_1283</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037233180.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87582">
        <property type="protein sequence ID" value="BAV87582"/>
        <property type="gene ID" value="RA11412_1283"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1283"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="29"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="205" mass="22357" checksum="DDF70EC5E17E75DF" modified="2018-10-10" version="1">MSEQHYFSSSPETEFKPRTVQVELAGREVSVTTANGIFSPSGIDKGTAVLLGQAPAPHGKYMLDIGCGWGPIALSLAMLAPQAEVHAVDVNSRSLSLTEQNARALGLQNVSVSTPDEVDPTLRFDTIWSNPPIRVGKEVLHNILLTWLPRLAPGGAAYLVVQKNLGSDSLQKWLDAHFLERFEGEFTVSRYATSKGFRVLEVLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYR6</accession>
    <name>A0A2Z5QYR6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87608">
        <property type="protein sequence ID" value="BAV87608"/>
        <property type="gene ID" value="RA11412_1309"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1309"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="118" mass="12440" checksum="3D2E5CF081F2C092" modified="2018-10-10" version="1">MSAIICFIHGLISAFAPGNAKPLEGLPEFGVAGGIGLLVVSAAVYLTVYFMVQNGNRLGLTIGLIFAILGGLIAIMSLLGNILDTQRYGFVPLYAGWFIANVLWIRAAFDPAVKAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYX0</accession>
    <name>A0A2Z5QYX0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">gatC</name>
        <name evidence="3" type="ORF">I6I94_03365</name>
        <name evidence="4" type="ORF">NCTC10207_00597</name>
        <name evidence="2" type="ORF">RA11412_1182</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888268.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87481">
        <property type="protein sequence ID" value="BAV87481"/>
        <property type="gene ID" value="RA11412_1182"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1182"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI22519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="98" mass="10664" checksum="CA4BAA35F2C4E11E" modified="2018-10-10" version="1">MSAITFEQVKHLAELARIEMTHDELTAMATELDIIVSSVENLSEIVTSDTPATSHPIPLTNVFREDVVGETLTQEEALSGAPDAQDGKFRVPAILDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYZ7</accession>
    <name>A0A2Z5QYZ7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87672">
        <property type="protein sequence ID" value="BAV87672"/>
        <property type="gene ID" value="RA11412_1373"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1373"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="59"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="209" mass="23027" checksum="E373D77803EB8DB9" modified="2018-10-10" version="1">MDGDEEDAFTASVGPSGWNRHAGATTLLTSHPATTGEIQVARGSARSILFDTRQHVSYSERVRKLIRATDATYDLVLIDCPPFMGTLTSVGWAASQRILSIAEPSLFSVAGTERTLRGIARFKDNNEQDIEGAAVIINRMRPNDPEHLYRREEMRTLFGGLVVEPTLWESSAVQRAQGAAFPIHYWPDEEAVDPATRFTRLLTGLVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ45</accession>
    <name>A0A2Z5QZ45_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Homoserine kinase</fullName>
            <shortName evidence="10">HK</shortName>
            <shortName evidence="10">HSK</shortName>
            <ecNumber evidence="4 10">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thrB</name>
        <name evidence="13" type="ORF">I6I94_02245</name>
        <name evidence="12" type="ORF">RA11412_1456</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4 10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87755">
        <property type="protein sequence ID" value="BAV87755"/>
        <property type="gene ID" value="RA11412_1456"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1456"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="11">
        <location>
            <begin position="97"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV87755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT89471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="326" mass="34886" checksum="F59F2208696CCD1C" modified="2018-10-10" version="1">MSLNSIPLTLTDIPVGKTVTVKVPASSANLGPGYDTLGLALGYYDELTVERIAEGLEFELSGEGSDTVPRNENHLVVRSMRTVFEKVGLDELPALRLTAHNRIPHSRGMGSSASAIVAGVAAASALLPEYARLSRDQIFQIASDVEGHPDNVAPSVYGSLSISWGELGDWHSLIVPVHPTIVPVVAVPDYEVSTKLARSLIPAEIPHGQAAANSGRAALLIQSLAQAPEHLMDATVDYLHQGYRVPAMQPSAALVAYLREQQLPAVISGAGPTVLTFAHGAKEASRVCEFVEKFMAEHPGNIFENRHLSWRVMPLEIDGEGVIVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ48</accession>
    <name>A0A2Z5QZ48_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87504">
        <property type="protein sequence ID" value="BAV87504"/>
        <property type="gene ID" value="RA11412_1205"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1205"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="306" mass="33178" checksum="1E6B20CEABC10A3E" modified="2018-10-10" version="1">MGDPRSEQEAQQRASFGEASDAPFSRTLVVTDSGVPIAAGVVTASLLHPQRLWTYLEVAEGHRRAGLGTELLDRLREIAAENAQVPNVRVKLAPFSTGEEFAQAKGMKMIQRSRLVHIDAGAIPPVSLREDENGKPTQAIEDLATGSVELTSKLWEFYRNSHDWDVPAEVGLGTVNRYFLSDEARAFGALVLRDNIQQAEKEGKKGEIIAFAVSYHPFETDPAAALVDENTATEILLGYDMQNEGAVEAIMQLLSLLTAQYPVVVEVDDSMTALVEVTDVLLRAGTASVEGDPTYIYASDYPGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ78</accession>
    <name>A0A2Z5QZ78_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87795">
        <property type="protein sequence ID" value="BAV87795"/>
        <property type="gene ID" value="RA11412_1496"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1496"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="50" mass="5833" checksum="DD420553AF444C8E" modified="2018-10-10" version="1">MLEDEIYDSDALGNYDAFILKCIKFAEKNIIPLSQYRKELEGVIKQCTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZG8</accession>
    <name>A0A2Z5QZG8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="8">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">metG</name>
        <name evidence="13" type="ORF">I6I94_01915</name>
        <name evidence="12" type="ORF">RA11412_1538</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888672.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87837">
        <property type="protein sequence ID" value="BAV87837"/>
        <property type="gene ID" value="RA11412_1538"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1538"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="10">
        <location>
            <begin position="6"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="11">
        <location>
            <begin position="375"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="300"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV87837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT89409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="515" mass="57983" checksum="D09060D7767DB0A0" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZI3</accession>
    <name>A0A2Z5QZI3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">atpG</name>
        <name evidence="11" type="ORF">I6I94_02165</name>
        <name evidence="12" type="ORF">NCTC10207_00858</name>
        <name evidence="10" type="ORF">RA11412_1474</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888889.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87773">
        <property type="protein sequence ID" value="BAV87773"/>
        <property type="gene ID" value="RA11412_1474"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1474"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VEI22772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="314" mass="34782" checksum="0A056188337B9B03" modified="2018-10-10" version="1">MGAQIRVYRQKIASTSSMKKIFKAMEMIATSRINKARRSAQAAGPYANALTRVVTALATQQSVQHPLIHGPGAIGKSKHKRSAVLVVTSDRGLAGSYSSSVLKKTESLIEKLRGEGREVNLYLVGRKAKSYFEFRERPYVRAWEGHTDSPRIDTAVEIRDVFLEAYSKPFEEGGVDDLHVVYTEFKSMVTQETKILRLLPIHVAEAQHLGEEIVPDEELTQADYVQPAVFEFEPSPQEVLDALLPRYIASRLFACLLQAAASELASRQRAMKTAGDNAETLINKYTRLMNNARQAEITQELSEIVGGADALASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZZ4</accession>
    <name>A0A2Z5QZZ4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87861">
        <property type="protein sequence ID" value="BAV87861"/>
        <property type="gene ID" value="RA11412_1562"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1562"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="82" mass="9178" checksum="89051D3EBDBE2B0C" modified="2018-10-10" version="1">MNSYLGKKDGTLSEDQIGEARVRDGDASLEVIAIVVERDGDGRIDRYRTIPSTLQKTQEIDWHNAKDPNEPANSLAFELSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZZ7</accession>
    <name>A0A2Z5QZZ7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87943">
        <property type="protein sequence ID" value="BAV87943"/>
        <property type="gene ID" value="RA11412_1644"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1644"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="55" mass="6079" checksum="2159123E377D981E" modified="2018-10-10" version="1">MGRRISKARLKANANEVSDRHSADHTCLNTPNSKDILDSEIACIYTDADSYEPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R003</accession>
    <name>A0A2Z5R003_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6493 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">RA11412_1738</name>
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    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88037">
        <property type="protein sequence ID" value="BAV88037"/>
        <property type="gene ID" value="RA11412_1738"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1738"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="243" mass="26565" checksum="0AD41B25CCC5D021" modified="2018-10-10" version="1">MFAESLKGLLAADTNPDATTYRSFYLGMQPNGQEITEHATELIALLCSQPSTVVGLAQKQLLPILGELTDHQVHTLVDASQAVLMRTEKKILKSQLRILAELVKARPHLCEQITRIVGQAASTLPVELRDQAGHITGKLLSHAADNTDTNAPTAQPGSIPDAVPQHREPDDFFTSRPPIDSAAQAQEILFELLNNTGDGADIPRLLAYIAEYRNIDLDKAQQEYLKNISKIVTEIPTITSNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R027</accession>
    <name>A0A2Z5R027_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4253 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_01025</name>
        <name evidence="2" type="ORF">RA11412_1769</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88068">
        <property type="protein sequence ID" value="BAV88068"/>
        <property type="gene ID" value="RA11412_1769"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1769"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025349">
        <property type="entry name" value="DUF4253"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14062">
        <property type="entry name" value="DUF4253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4253" evidence="1">
        <location>
            <begin position="170"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="276" mass="30846" checksum="9F38E3336DFD6047" modified="2018-10-10" version="1">MPEPYDRFIALYPYPHERIRRGEPHEELNRRYLNRCEKGREEGFTPVVVALDQTLLGTMLNNISVRTGVPSESVTAEQVRQHAHTIIEEYHSALAGASVESLAHAAFERLSPDTFKGSYHELVEGEALIIPGEYGTEATAMQPKPLTLMSAYINEEADTQNSDAAGELILLDMPVTEPAEALAYLPFGGWVGCPDAADFMAIAHYWQERDEAVPAVVAAQYTEFYTPEPVNTTLDAAILAAEQCMLSPAMLTDVYRGFSKLSESLYGSHNWYIWWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0H6</accession>
    <name>A0A2Z5R0H6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6493 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88030">
        <property type="protein sequence ID" value="BAV88030"/>
        <property type="gene ID" value="RA11412_1731"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1731"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="365"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="578" mass="64037" checksum="FA0463EE78B99CCF" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0I6</accession>
    <name>A0A2Z5R0I6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uricase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88285">
        <property type="protein sequence ID" value="BAV88285"/>
        <property type="gene ID" value="RA11412_1986"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1986"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016421516" evidence="2">
        <location>
            <begin position="39"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="95"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="392" mass="44115" checksum="B80B39B04AE90608" modified="2018-10-10" version="1">MLRSMTIHNSLFSRRTFVVGSIIPLIAGCSSKNTVENAAETRFIAAPTGTPHSDDASPTAAVDSPEPAEPPVSKNPIAKPHPWKDIQYRLAGEGHYVAWTVDDGANPETVRAYAEFAAKTGTRLTFFINASYTSFEQNLDVLLPLVKSGQIQIANHTYNHPNLLNLDDKQVKEEFVRNEEEIMRLFGVSSKPYFRPPYGYYDDRVLKIAAKAGFSRPVLWEGTTGDEGQTTQRVVLKRTKKYMKPQRIMLGHLNYTTIISLLERIKELLDERGLVTVTLRDYYGEASEEELKIVRDAEAEEKKKEEEKRSRRRKRKIRTVSLSKATAAKPAADNSQQRQCGEGSPAPHCMGSRVHHGIIERMSSPPESRKVPKCWFILWCLSPVIVAESNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Q6</accession>
    <name>A0A2Z5R0Q6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88071">
        <property type="protein sequence ID" value="BAV88071"/>
        <property type="gene ID" value="RA11412_1772"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1772"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="174" mass="17704" checksum="0F86061B94097F6E" modified="2018-10-10" version="1">MSAATPYRPSSARSLALVAVFAAFIAVLGPLSIPIAGVPVPLSLGPLAIYVTALVLGGIRAFAATSLYVLMGCLGLPIFAQGGSGFGSLAGPTGGYLIGYPFGALAAGMVAYLVVRRRLNPALTVILLAAAAMIGFVTLSTGGLIGLIFNGRMSFEKQLASSYLSRCLIPPKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Q8</accession>
    <name>A0A2Z5R0Q8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88074">
        <property type="protein sequence ID" value="BAV88074"/>
        <property type="gene ID" value="RA11412_1775"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1775"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="45" mass="4900" checksum="3FFFD1D5FAAC65AC" modified="2018-10-10" version="1">MGFAGESIGFEILAAVVMEKPLAIVGFPYKNPLYCRYIADSNVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0X0</accession>
    <name>A0A2Z5R0X0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator receiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86519">
        <property type="protein sequence ID" value="BAV86519"/>
        <property type="gene ID" value="RA11412_0220"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0220"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="114" mass="12147" checksum="5B70B653C662D641" modified="2018-10-10" version="1">MSGAVPGYVHISQRGRAAKRQAPQPSRPQAPAATLRPMTFTANDHSPKGGAHENEARGFVLYVGLNEELAAANGTSLVRIVQDLRNYAHHLAPEAESYAAVALAPPVRRGATLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Z9</accession>
    <name>A0A2Z5R0Z9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88154">
        <property type="protein sequence ID" value="BAV88154"/>
        <property type="gene ID" value="RA11412_1855"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1855"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="75"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="202" mass="21812" checksum="34ED10FED9ECC91F" modified="2018-10-10" version="1">MAQRANGRRGRGGALDNAWRTVEPAPAVLLYGAEEYFASRARQRLRGLYGSTHPDLEIVRMNASSYTRGDLTIQASPSLFGSTKLIEVEALGAMNDDFLTDALAYLSAPEPGIMLVMHHSGGNRGKKLIDTVRTQFTLVNCKPLKTDREKTEFIHSEFSSAKRRIAPAAVTLLAAAAADTAELASACAQLIADIPGILPKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R111</accession>
    <name>A0A2Z5R111_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88427">
        <property type="protein sequence ID" value="BAV88427"/>
        <property type="gene ID" value="RA11412_2128"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2128"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="63" mass="7120" checksum="7CC7763FF6DECFA0" modified="2018-10-10" version="1">MLWDGAGEENYTAQYSPLPFTSKTQSNTAKPNTEPPCSVKSARYRQKYLWLFSCKSAGTQPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R196</accession>
    <name>A0A2Z5R196_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Duplicated ATPase component BL0693</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88320">
        <property type="protein sequence ID" value="BAV88320"/>
        <property type="gene ID" value="RA11412_2021"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2021"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="13"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="288"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="326"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="515" mass="55729" checksum="236CA43A84DC86FC" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1A8</accession>
    <name>A0A2Z5R1A8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_1997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88296">
        <property type="protein sequence ID" value="BAV88296"/>
        <property type="gene ID" value="RA11412_1997"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1997"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="203" mass="22530" checksum="539197B4AC02DE91" modified="2018-10-10" version="1">MFDLDEVVFVPTGQPWQKTGQRRVSDPEHRYLMTVIATASNPRFTVSRIDIDRGGATYTFDTLNELRQLRPDADLFFITGADAISQMMTWHNAHKLWDLASFVGVTRPDHELDPPVGEGRQITTLEIPAMAISSTDIRRRASDGAPIWYLVPDGVVQYINKYGLYSADDSTSTYDAGLPRGEAVEGSSAQGALDNVYVTEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1B4</accession>
    <name>A0A2Z5R1B4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88340">
        <property type="protein sequence ID" value="BAV88340"/>
        <property type="gene ID" value="RA11412_2041"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2041"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpB_D2-small" evidence="2">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="142" mass="15771" checksum="D212EC9B0CE4EC3A" modified="2018-10-10" version="1">MAHYGLIPELIGRLPVVTTLQQLTEEELYQVLTEPKNALMKQYKHLFALDGVDLMFEEEAIRIVAHRAAERNSGARGLRAMMESILLPIMFDIPDRDDITAVVITEAAARGEGEPAYVLEAIEKPAKPRTRKSSTAAKKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1L5</accession>
    <name>A0A2Z5R1L5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88394">
        <property type="protein sequence ID" value="BAV88394"/>
        <property type="gene ID" value="RA11412_2095"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2095"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="54" mass="5763" checksum="3798BC422ACACAAF" modified="2018-10-10" version="1">MWTATTYGRTPAIEVTFDADKVPSSTLLTSLSSAVKQIPAQKKCTNLNEVPGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1N8</accession>
    <name>A0A2Z5R1N8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86759">
        <property type="protein sequence ID" value="BAV86759"/>
        <property type="gene ID" value="RA11412_0460"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0460"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="62" mass="6612" checksum="23352657506A0217" modified="2018-10-10" version="1">MGVVMLVLWIGGIILSATLIGALIGVPMLIAWIVLWIIDACTMPNRINELNGVVAVAPTRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1T5</accession>
    <name>A0A2Z5R1T5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aminopeptidase P family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_09960</name>
        <name evidence="8" type="ORF">RA11412_2369</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88668">
        <property type="protein sequence ID" value="BAV88668"/>
        <property type="gene ID" value="RA11412_2369"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2369"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="7">
        <location>
            <begin position="46"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="509" mass="56481" checksum="7DC886145203ED25" modified="2018-10-10" version="1">MSENTKKSTEAPETDHRDTPKASAFQEFIASNWEPAADDGYTRERVADFAAQRRKKISQKFPGERLVLPAGPLKVRSNDCDYRFRPHSAFAHQTGLGVDHEADAVLVFEPVEEGTGDNGSNHEVTLYFRPLAGRDTTQFYADARYGEFWVGPRPTLKEFSERYGVRTKDLSELEVAITKNAGAQDLGGVRIRLVREVDPSIDALVDTSRYNTGVALEESDKLDSELTVALSEARLIKDEIEVENLQRSVDMTVKGFEEVVRELPKAVAHHRGERVVETAFFSVARTDGNDLGYDTIAACGNNATILHWIRNNGTVDEGKLLLLDAGVEDDTLYTADVTRTFPVNGKFTEIQAKVYNAVLDAADAAFKVAVPGRKFHEIHDAAMEVLAHRLEEWGLLPVSAEVSLTVEGGQHRRWMPHGTSHHLGLDVHDCAQAKAELYTGATLEPGMVFTIEPALYFKDEDLSVPKEYRGIGIRLEDDVLCTEDGNVNLSAALPRTVEEIEAWMAKLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1T8</accession>
    <name>A0A2Z5R1T8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86839">
        <property type="protein sequence ID" value="BAV86839"/>
        <property type="gene ID" value="RA11412_0540"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0540"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="65" mass="7439" checksum="048656D39FEA2A0C" modified="2018-10-10" version="1">MKDLLPGSSAVRSKQLKSLLDRDLLYRPEGTRKYSSRTWGNDLSIHLVRRLDELGMLPSILRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R209</accession>
    <name>A0A2Z5R209_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exodeoxyribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88785">
        <property type="protein sequence ID" value="BAV88785"/>
        <property type="gene ID" value="RA11412_2486"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2486"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="310" mass="34728" checksum="03358521C9B7A535" modified="2018-10-10" version="1">MLLNARPLENYIPMLFLTLNTHSWCEPHQIVKIHELARFIAHHRVDVIALQEVNQYLHSPIVDTPLGYQGGAGIPIREDNYALLLVRFLADLGLQYEWALTETHIGWDRYDECVAVLSRVPIERIDPLVMSPQYSYDRVERRSSLAVRVGTDAGSVWCASAHMSWWDFQGEPLFAQEFARLSQALTERGQDAPVLLGGDFNTAAQVRGEGYDLALSSGLVDTREIAERTDGEFTVHRGIAGWEGQEDAKRIDFVFADRAVKVLSHAVVFRDNSPEAISDHSGVLVELDESSFEPTARMHPVPLPSQAQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R224</accession>
    <name>A0A2Z5R224_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88526">
        <property type="protein sequence ID" value="BAV88526"/>
        <property type="gene ID" value="RA11412_2227"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2227"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="98" mass="10523" checksum="0B20A5A934175808" modified="2018-10-10" version="1">MMVFSVLSALGWLAIGGSLALLILTAFLNPDFRKSEDPNNPVSTWLILAFCIFGASWVYTLTLQNGNTHPGINAALALVPTAAMGWVFIKHSAHAHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R288</accession>
    <name>A0A2Z5R288_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88670">
        <property type="protein sequence ID" value="BAV88670"/>
        <property type="gene ID" value="RA11412_2371"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2371"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="4704" checksum="1816990FA733DFAF" modified="2018-10-10" version="1">MRTLYKGPLAVGVTRCVSTPVRPCDLKTGSADGAPTLRRAHPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R294</accession>
    <name>A0A2Z5R294_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88712">
        <property type="protein sequence ID" value="BAV88712"/>
        <property type="gene ID" value="RA11412_2413"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2413"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="68" mass="6843" checksum="A678B47ABFA695AA" modified="2018-10-10" version="1">MGAPAFALPLLEDEDDGEELLLSGLAYTVTVLGVGSGVAVTVTTDGEDEGEALLVAADAADDDEECDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2A0</accession>
    <name>A0A2Z5R2A0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I6I94_09040</name>
        <name evidence="12" type="ORF">RA11412_2588</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88887">
        <property type="protein sequence ID" value="BAV88887"/>
        <property type="gene ID" value="RA11412_2588"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2588"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004644">
        <property type="entry name" value="Fe-S_L-Ser_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00720">
        <property type="entry name" value="sda_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_beta" evidence="11">
        <location>
            <begin position="35"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_alpha" evidence="10">
        <location>
            <begin position="234"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV88887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT88657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="510" mass="53482" checksum="B3E54A67B9C999B1" modified="2018-10-10" version="1">MALNIGAPDDDRNPSTASIPSAVQKKAEALEYDISVFELFSVGVGPSSSHTVGPMRASNRFIAELIDANLLDRVSRIHVDLYGSLAATGAGHGTMSAALKGLCGFVPETICIADAEAMMQRNSVDGTLPLAGYPSQAYTGGAPGSEDGKVYGPVLNYREAEMTLRPLTVLPRHTNGMKITAFAGEQILAERTYFSIGGGFVVEGDEEATGGASLSNPPYPFGSGAELLQLANDAGLSIAELKMANECSVRSEQEVRAGILGIRQVMKECIGSSLSRVGYLPGPLKVRCRAGAWHRDLMVEDPEKSAEFATDWVNLIALAVNEENAFGGRVVTAPTNGASGIIPAVLHYAMNYTPGIRHCGQAAREDAVVKFFLAAASIGALYKKRASISGAEVGCQGEVGTASSMAAAGLAQVLGGTNEQIENAAEIAMEHNLGLTCDPVGGLVQIPCIERNAMAASNAVTAARMALRGDGVHRVSLDQVIETMRQTGMDMSHRYKETSMGGLALNVVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2C1</accession>
    <name>A0A2Z5R2C1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-dependent metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_10135</name>
        <name evidence="2" type="ORF">RA11412_2322</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037286219.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88621">
        <property type="protein sequence ID" value="BAV88621"/>
        <property type="gene ID" value="RA11412_2322"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2322"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="468" mass="52025" checksum="86400F3C29C7D959" modified="2018-10-10" version="1">MTNSPNNNNPGNGDSGDGRDPLEDFLKKMQESGFDPSDNNNPLGASSLNPEDLKNMGLPFDPSMMQGILEQMNTMFSINATPGSTPEQGVNWTGVKDQARRMIAADSDPSIAENLKQAAADAAHLADLWLDSVTVFERHNIPVEAWSKAEWLDASFNSWREMVEPVAAEVTQAMVLPGTDNVPEELSQLLGNSGFLNNLGSTFFGIQMAQALASLAKEVYSSTDIGFPLAPGRTALLPNGFKTLGDEIEVPAQEVLLYLAVRESALIRLHRTNPWLREDIMALVSRYARGIRVDMNRIQDAASQVNMHDPEAVQEAFEGGMFNPQRTEDQELAVERLEALLALIEGWVSFVADQATQNLPKAPQIAETFARRRVEGGPSEQVFETLVGLEIRPRMVREATAFWRDYDEKHGYEARDNLWLAPETLPTAKELENFKKYEDRVSEQLSFDDVDFDSELKKLLDGGYDDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2C7</accession>
    <name>A0A2Z5R2C7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_05030</name>
        <name evidence="1" type="ORF">RA11412_0750</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87049">
        <property type="protein sequence ID" value="BAV87049"/>
        <property type="gene ID" value="RA11412_0750"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0750"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="109" mass="12249" checksum="ABC1F08838F2769A" modified="2018-10-10" version="1">MIATTRLTFFLAATSDAAAERVLNRVRRELTELNLTVTARDKNIFEIQQPIHSWEHHVYGLLKLCGHLGRQWVLTGDIGHLFDAFSSHSAVAGVEAVHLTCDNPQAYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2D7</accession>
    <name>A0A2Z5R2D7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88925">
        <property type="protein sequence ID" value="BAV88925"/>
        <property type="gene ID" value="RA11412_2626"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2626"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="199" mass="21340" checksum="7C3453CCE8D236D4" modified="2018-10-10" version="1">MFTDEIYEHLTYDGVNSVSILKVVPELTPNCIILNGVAKTYAMTGWRVGWMVGPQDVIAAASNLQSHLSSNVNNIAQRAALAALAGPQDEVAVMHAAFDRRRKAIVAGLNAIEGVHCPTPQGAFYAYPDVRGLLGKEFDGVRPQTSAELADLILEKALVAVVPGEAFGPSGYLRLSYALSDEDLAEGVERLQKFLGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2E2</accession>
    <name>A0A2Z5R2E2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">6-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88927">
        <property type="protein sequence ID" value="BAV88927"/>
        <property type="gene ID" value="RA11412_2628"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2628"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="46" mass="5276" checksum="BC3ECA0B06841D02" modified="2018-10-10" version="1">MNQKLWGKMVSLQATNIVYVPLEEALDGLKMVPQERWDEAAVLFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2F1</accession>
    <name>A0A2Z5R2F1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyphosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88937">
        <property type="protein sequence ID" value="BAV88937"/>
        <property type="gene ID" value="RA11412_2638"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2638"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="79" mass="9602" checksum="155AAAEB775ED414" modified="2018-10-10" version="1">MMHRNLDRRIEALVRIKDPRHIKYLLDMFTVYMSDESRTWHLDANGTWTRFNQDAEGNPLRDVQSHYLRSRSRKNVDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2G3</accession>
    <name>A0A2Z5R2G3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88714">
        <property type="protein sequence ID" value="BAV88714"/>
        <property type="gene ID" value="RA11412_2415"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2415"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4479" checksum="CF0F9C6A7D65927C" modified="2018-10-10" version="1">MRIRPLPGADERKTMKKLIVIALIGAVAFVILKKKGFIGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2K3</accession>
    <name>A0A2Z5R2K3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88923">
        <property type="protein sequence ID" value="BAV88923"/>
        <property type="gene ID" value="RA11412_2624"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2624"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="4828" checksum="145E8FC9E49CDCA0" modified="2018-10-10" version="1">MAKSATAETVSESAEDKTRRSLFQYIREVITELKKVTTPPVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2K8</accession>
    <name>A0A2Z5R2K8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tat (Twin-arginine translocation) pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_09830</name>
        <name evidence="4" type="ORF">RA11412_2402</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88701">
        <property type="protein sequence ID" value="BAV88701"/>
        <property type="gene ID" value="RA11412_2402"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2402"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046281">
        <property type="entry name" value="DUF6318"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19843">
        <property type="entry name" value="DUF6318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340115" evidence="2">
        <location>
            <begin position="27"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6318" evidence="3">
        <location>
            <begin position="74"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="245" mass="26304" checksum="B0A6BCCE9CA42698" modified="2018-10-10" version="1">MTSAMTRRTALTTLGAGSIAALTACSASLTTANTAGTHDSNGASSANNNSKAKASERSDYSGAVEFNSYDTSAGEYKPATRTSPPQNVPKPIKPENMDEHSVAGLYSAIGFFTTALTYAFVTGDLGPLDHLPFSDTYTNTFKKQIRETTQEMDGAWFEELKIAFTLNTAQPTQDGDNYKWPAKYIFSLGSFVVYRGVPVDLPHDKQSSTEEALITAQYKDGRWILSETNDNGGGSFGPSGGNFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2N1</accession>
    <name>A0A2Z5R2N1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Niacin transporter NiaP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_2654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88953">
        <property type="protein sequence ID" value="BAV88953"/>
        <property type="gene ID" value="RA11412_2654"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2654"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="374" mass="39693" checksum="10CF6DE83563FD25" modified="2018-10-10" version="1">MALGATVGGLLADRFGRRYIFAATLLIYGLATGASALAGSLAVLMVFRFIVGLGLGAELPVASTLMSEFSPRAIRGRVVVILEAFWALGWILAALIGTFVVPNPNGWRWALAIGVIPALYSLIIRWGTPESVRFLESKGRTDEAERVVAEFESSAALSTCAHADETNRDNAPETPANDAQEATSIWSAPLRKRTLALCTVWFCINLSYYGAFIWIPSLLSAQGFSLVKSFAFTLIMTLAQLPGYAVAAYLIEKWGRRATLAVFLAGSAGAAVCYGLSHSDFYIILSGCFLSFFNLGAWGALYAISPEVFPTRLRGTGTGTAAGLGRIASILAPLIVPPLISFGGTGVLFAVFAAAFLLAAVTTFALPEKRGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2U2</accession>
    <name>A0A2Z5R2U2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellulose 1,4-beta-cellobiosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_08220</name>
        <name evidence="3" type="ORF">RA11412_2786</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89085">
        <property type="protein sequence ID" value="BAV89085"/>
        <property type="gene ID" value="RA11412_2786"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2786"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340127" evidence="2">
        <location>
            <begin position="41"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV89085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="179" mass="17985" checksum="51CE170F08E8EC63" modified="2018-10-10" version="1">MRTSLYKGSVPVAATLAGTLILSACGGGATSSSSEATSSAATSTPAQSSASAAAPNTSASGGAGGSSDSDRTTIAWTKDEPDGNKYVVFQDGSWTITGPKGESTNVLADGSWSYTTASEKGQLIKEAARVDADGTFRVLKEGAVSNEPPKLPKAPEKPDNSAVTPVTPVQPTKSITDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2U5</accession>
    <name>A0A2Z5R2U5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellulose 1,4-beta-cellobiosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_08210</name>
        <name evidence="3" type="ORF">RA11412_2788</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89087">
        <property type="protein sequence ID" value="BAV89087"/>
        <property type="gene ID" value="RA11412_2788"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2788"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340158" evidence="2">
        <location>
            <begin position="36"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV89087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="259" mass="25772" checksum="8E5905C5832D2CC1" modified="2018-10-10" version="1">MKSSARKLYVLLSCTVAGVCLLSACGGTSNETRQASDAVASAQAEISKAKASSESASSASPSTSATLGMSPSSSDHTPSGHAQPVEPEKTASAAQTPSSSPAAASAAAAGATPSVKASTASPQHNETGTIDLGFGTIQEVTTIENDGAWEAHSAQGTTVQVDDDGSWSVNGTKGILAVDSDGSWTWTSHPSGGMVTVERNGSWTWTGGPYGIAEVKVDGSYSATSGGKPQVPAKPAAIGKPSNEKAAAPAVPATPKQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2W0</accession>
    <name>A0A2Z5R2W0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SRPBCC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_08435</name>
        <name evidence="1" type="ORF">RA11412_2734</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89033">
        <property type="protein sequence ID" value="BAV89033"/>
        <property type="gene ID" value="RA11412_2734"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2734"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="146" mass="17068" checksum="344B6CE1C7173E36" modified="2018-10-10" version="1">MAVYTRQVLVNAPPNQVFRYCTSQTGFCQQFPFPVRWLTGTDHWQLGDILDFRYRVCGLWLRHRAEVEKHEWGALFTDTMRKGPYRTFRHTHRFEPSAGGTCMTDTIEFTTGLGALIDRLIGVPILKYTFRKRHEALSQVDWADVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2W7</accession>
    <name>A0A2Z5R2W7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NarK/NasA family nitrate transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Nitrate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I6I94_09025</name>
        <name evidence="10" type="ORF">RA11412_2591</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88890">
        <property type="protein sequence ID" value="BAV88890"/>
        <property type="gene ID" value="RA11412_2591"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2591"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="18"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="9">
        <location>
            <begin position="362"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT88654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="407" mass="42419" checksum="4B6263DF39C73AC2" modified="2018-10-10" version="1">MEASEVKHADLKKGQLRNLLVATFASIFAYWAWSVISPLAKFYSSPDQMHLDEGGSSLLIAMPVLVGAVGRIPAGALTDKYGGRVMLTAVMALSAPLTLLVALAGSMKSFGLMLVFSFLLGIAGTVFAVGIPFSAAWYGASKKGFATGIYGVSTVGTAVSAFVTPILHRQLGYWPTHILLAALCLVMAAVCFTVLRDSPQFTRSAEPIIPKLLAASRVKETWQLCFLYSIFFGAFVAFSNYLPTFLTNVYEKNLIEAGMRASGFAVAAVVARPLGGILADRVGPRLVTLIGMGGTVVLGASVAFQPEGEHVYGPLFLMMAVLLGLGCGSVFGWVGRAIPADKVGIASGIIGAAGGLGGFFPPLVMGATYNAAANSYFNGLMLLALTAAVGVGMTLIVRGGKKSLDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R331</accession>
    <name>A0A2Z5R331_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2'-5' RNA ligase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">RNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_03955</name>
        <name evidence="1" type="ORF">RA11412_1020</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87319">
        <property type="protein sequence ID" value="BAV87319"/>
        <property type="gene ID" value="RA11412_1020"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1020"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="190" mass="20622" checksum="E9D589E2E57B545A" modified="2018-10-10" version="1">MTAEYTASLRRPSPTLKEGQRYLSLIAHVPDPLASRLLGWKREQDIAVGLSAHVTVYVGQLSEQVEAGLRSVKFAQALGDTGTVRLQVGGVSTFRPVTEVDYLSIDYGADALHQLHQVCVRELGECATPFPYVPHITLGQNLCPGQVAEAKTVFDALPAAERSFAVDALHAYTYDGAEWELLGSIDLAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R339</accession>
    <name>A0A2Z5R339_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nitrate reductase (quinone)</fullName>
            <ecNumber evidence="5">1.7.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I6I94_09000</name>
        <name evidence="13" type="ORF">RA11412_2597</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinol + nitrate = a quinone + H2O + nitrite</text>
            <dbReference type="Rhea" id="RHEA:56144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.7.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.5.1" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88896">
        <property type="protein sequence ID" value="BAV88896"/>
        <property type="gene ID" value="RA11412_2597"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2597"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02776">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037943">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006468">
        <property type="entry name" value="NarG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01580">
        <property type="entry name" value="narG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="12">
        <location>
            <begin position="56"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1006"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1006"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV88896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT88649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="1240" mass="138988" checksum="4CDEC79A0C0E9B50" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R377</accession>
    <name>A0A2Z5R377_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dCTP deaminase, dUMP-forming</fullName>
            <ecNumber evidence="3">3.5.4.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Bifunctional dCTP deaminase:dUTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">DCD-DUT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">dcd</name>
        <name evidence="5" type="ORF">I6I94_08395</name>
        <name evidence="6" type="ORF">NCTC10207_01928</name>
        <name evidence="4" type="ORF">RA11412_2745</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dCTP + 2 H2O = diphosphate + dUMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19205"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.5.4.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.30" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89044">
        <property type="protein sequence ID" value="BAV89044"/>
        <property type="gene ID" value="RA11412_2745"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2745"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033973">
        <property type="term" value="F:dCTP deaminase (dUMP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010550">
        <property type="entry name" value="dCTP_deam_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06559">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="101"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for bifunctional activity" evidence="3">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV89044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VEI24142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="199" mass="22244" checksum="66B7F62B68925C42" modified="2018-10-10" version="1">MLISDRDIRQEIADGRIVLNPFDDSMIQPASVDVRIDRFFRLFDNHKYPYIDPSQPQEDLTRLVEVAPDEPFILHPGEFVLGSTYEKVTLPSDVAARLEGKSSLGRLGLMTHSTAGFIDPGFSGHVTLELSNMATLPVMLWPGSKVGQLCFFRLTSETEHPYGSGAYGNRYQGQRGPTASRSYLNFHRTEIPVTENPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3B6</accession>
    <name>A0A2Z5R3B6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">JCM 11412</strain>
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        </source>
    </evidence>
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</entry>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
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                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
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        <source>
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    </evidence>
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</entry>
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                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
    <sequence length="205" mass="22878" checksum="32A1A721F233A75B" modified="2018-10-10" version="1">MSFFVDIHALQTLPPSNINRDDTGSPKSAIFGGVSRQRVSSQAWKSVIRRNFEEHLDRSEIGVRTRQVADMIVDRITNISPDFDPDKAESAVVDAFKAAKIKLEKPKAKKGEENTGRAVSGYLLFLSNQQITRLANAIIEANGEKIPAKEVKDILDTNIVLILHSLAVCWPTPQISTWMPLARWHMPLGYMVRNLILTTTLPSTT</sequence>
</entry>
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    <reference evidence="2 3" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="54"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAV88039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="290" mass="31984" checksum="754E747DDFF4001F" modified="2018-10-10" version="1">MCEPLPAVQRTWRRITVPQKPLNADFERIYGNYYVAWAVHEEQPVTTETPFEQAALLVDSVRAEYESRDTEQRELPAMRAVIQWYAWLTQNNPDIFAAHMMPAVKGAKFAKVIHGMEPALEAFEHAHQVLGEPSYSFLAYAASAAERQYRSATAQALAALADRDMLDTGMFAAELGWMLQGEYVIVGRVIETLQDAASISPLAGWRVCQVLQGLLPVVGELNRGGALVQLLAQLAGEYGVSVEIPEVLRPKMKGSTVLAKNLRALSALSPCSTELARQAQEQALAISDEE</sequence>
</entry>
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    <name>A0A2Z5R3X5_9MICC</name>
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        <lineage>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="40" mass="4690" checksum="FD3670BDE7D9A897" modified="2018-10-10" version="1">MLRGGFMTAPNFPHRLWRTLTRTAPRRLDTLISSPHRSLE</sequence>
</entry>
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    <accession>A0A2Z5R4H6</accession>
    <name>A0A2Z5R4H6_9MICC</name>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
            <dbReference type="EMBL" id="BAV88779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="754" mass="84206" checksum="3268F772D54A97E0" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4T7</accession>
    <name>A0A2Z5R4T7_9MICC</name>
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            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88859">
        <property type="protein sequence ID" value="BAV88859"/>
        <property type="gene ID" value="RA11412_2560"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2560"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="90" mass="9253" checksum="F3BD8D05B047F734" modified="2018-10-10" version="1">MLLVASLALLLLLLSGLLLLVSLALLLGRLLLLLLSGLLRLLTGASPNCSVGALANAAGMVPSEPATTDSAPAEAKSLREVTFLDEEVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R529</accession>
    <name>A0A2Z5R529_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89079">
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        <property type="gene ID" value="RA11412_2780"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2780"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="112" mass="11681" checksum="654635CAD5CCCD38" modified="2018-10-10" version="1">MSPDGSWVGKFSEEGIELSVAADGSWVMKKEGQGTITVAADGSWVRKGDDGATFTTKTDGTWVYTDAAGNTGTSEDGKAKVTIPKSPDMSAIKPSKDATTPKTPVQPKKVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVD2</accession>
    <name>A0A2Z5QVD2_9MICC</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">RA11412_0041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86340">
        <property type="protein sequence ID" value="BAV86340"/>
        <property type="gene ID" value="RA11412_0041"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0041"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="93" mass="10618" checksum="9A45DC16768E494A" modified="2018-10-10" version="1">MLEPLEPPLPPEELELPEVRPELPCEPLPCCFLVPEELDEEEEEPPFSVRLPPSFFSPLVPPLSECSSDEPGDSSEFWCSFSSSFSCRYCFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVG8</accession>
    <name>A0A2Z5QVG8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86388">
        <property type="protein sequence ID" value="BAV86388"/>
        <property type="gene ID" value="RA11412_0089"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0089"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025584">
        <property type="entry name" value="Cthe_2159"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14262">
        <property type="entry name" value="Cthe_2159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="112" mass="11721" checksum="6255B204BE46069A" modified="2018-10-10" version="1">MHTTGGLVISNGTLNVNSVKTGIKGKNYVDILGGEVSVNSQKDAIKATNSKEEGYGWARITGGTVKVIAGDDGLKAIRTVEIADGTLNIEKAREGVEGQYINILAARYPSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVL8</accession>
    <name>A0A2Z5QVL8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malonic semialdehyde reductase</fullName>
            <ecNumber evidence="3">1.1.1.298</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07975</name>
        <name evidence="2" type="ORF">RA11412_0045</name>
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    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Rothia</taxon>
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    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.298" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86344">
        <property type="protein sequence ID" value="BAV86344"/>
        <property type="gene ID" value="RA11412_0045"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0045"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="194" mass="21595" checksum="296B612761D4F549" modified="2018-10-10" version="1">MTRLNDEQLNTLFNEPRTVNAFTEQPVTDEQLQKIYELAAMGPTAFNSQPLRITWVKTPEARERLVKHMMDGNKEKTLNAPVTAVLAFDKNWQKRFGEFAPQAAAFESYYEAEEARIPAGALSSALQAGYFITAVRALGLDAGPMTGADFDGIAAEFFEGTDQQPFLVVNLGYGVAPEYPRGTRFEFDDVTRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVN1</accession>
    <name>A0A2Z5QVN1_9MICC</name>
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        <submittedName>
            <fullName evidence="2">MepB family protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_07615</name>
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    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
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            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT90131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86442">
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    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0143"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR038231">
        <property type="entry name" value="MepB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08877">
        <property type="entry name" value="MepB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032285">
        <property type="entry name" value="UCP032285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT90131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="147" mass="17573" checksum="5EBA39B01D231310" modified="2018-10-10" version="1">MKIIDILHEFYGDFDFIKEKWNEDYEGLLIKTKEEQKYKRCRLAKRTSKKEGYFTVFWKKDQNNNNVPYTNEDLGDELVIVVIDSYNSGLFIIPKEVAVNKRILSTRDSKGKMAMRFYPPWCTNLNKTAQSTQKWQLDYFRSYKIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVQ8</accession>
    <name>A0A2Z5QVQ8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86485">
        <property type="protein sequence ID" value="BAV86485"/>
        <property type="gene ID" value="RA11412_0186"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0186"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="38" mass="4160" checksum="F102099A17CF2006" modified="2018-10-10" version="1">MPLSIPEDTLHAHPLRLGRVWVNPVNLLAMICHCGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVX1</accession>
    <name>A0A2Z5QVX1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86530">
        <property type="protein sequence ID" value="BAV86530"/>
        <property type="gene ID" value="RA11412_0231"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0231"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="197" mass="21960" checksum="7F896EA7E352631D" modified="2018-10-10" version="1">MLMSTRRSFTLPETSPTQRTAVGERILIGRDAGYTQPVATPDGILLALIAYIPLPELFKLVPELALPVPAEHHDKAVYVFSYYDEHDYFLGNITELQPALLDTCVEIAHKNLHDFDHQKFFTPEFNADPDAMSFIGGSPVYLQHTLPDGLDDYVFVGQISGADLPSSLDDLFYLTENVGYIFVKKDLTGGLFFVQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW95</accession>
    <name>A0A2Z5QW95_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Phage lysin N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_06530</name>
        <name evidence="1" type="ORF">RA11412_0388</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86687">
        <property type="protein sequence ID" value="BAV86687"/>
        <property type="gene ID" value="RA11412_0388"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0388"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="168" mass="18216" checksum="F2DA7D43146F96BA" modified="2018-10-10" version="1">MANEHSGISRRKLLYTAAIGVPAAGALGLGANFAAASVAQPTLEADGWWGQQTTVQLQKFIFALYAQELGKPTYGYEEGIIKFQPAIRKKENPGLGSGWDWAADDGTQGYDFTIYYLQRWLGVETDGLIGPNTIKALQTHYGITADGRLDGPSDTIKALQNELNQHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWA7</accession>
    <name>A0A2Z5QWA7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86666">
        <property type="protein sequence ID" value="BAV86666"/>
        <property type="gene ID" value="RA11412_0367"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0367"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="115" mass="12804" checksum="F52255904C67C4CD" modified="2018-10-10" version="1">MEVTQENSHNRVYSRWEHDYTHTLTTGQGLGGRPVPAEFIDSVFDPKLRGEHPSGPARATYEAAKNNDTVTSYTVWTTTAPNRSVFSRQKATAFTLGEKQGRPRRQASTKPAAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWB5</accession>
    <name>A0A2Z5QWB5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86670">
        <property type="protein sequence ID" value="BAV86670"/>
        <property type="gene ID" value="RA11412_0371"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0371"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022435">
        <property type="entry name" value="Surface-anchored_actinobac"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03769">
        <property type="entry name" value="P_ac_wall_RPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="575" mass="58423" checksum="D83A8C6B1C1A524C" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWC3</accession>
    <name>A0A2Z5QWC3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 7">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_06565</name>
        <name evidence="8" type="ORF">RA11412_0381</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86680">
        <property type="protein sequence ID" value="BAV86680"/>
        <property type="gene ID" value="RA11412_0381"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0381"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="223" mass="25670" checksum="8478B9250CE3B62C" modified="2018-10-10" version="1">MSRSYEVIFENNQKWIDAKKQRQPDYFKELADGQNPDFLYIGCSDSRVSAEGLMGLEPGEVFVHRNVANLVHGLDMNAGSAIEYAVSHLKVEHIIICGHYNCGGVKAAMTAEDLGAMNPWLRNIRDVYRLHREELDAITDERQRYDRLVELNVQEQCLNVIKMACVQERYLLDGYPIVHGWVFDMRTGRLIDLDIDFENILADIQSIYNLTDSEWVVNARKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWE9</accession>
    <name>A0A2Z5QWE9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TIGR03773 family transporter-associated surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_06605</name>
        <name evidence="4" type="ORF">RA11412_0374</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86673">
        <property type="protein sequence ID" value="BAV86673"/>
        <property type="gene ID" value="RA11412_0374"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0374"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022395">
        <property type="entry name" value="CHP03773_ABC_transptr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022435">
        <property type="entry name" value="Surface-anchored_actinobac"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03773">
        <property type="entry name" value="anch_rpt_wall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03769">
        <property type="entry name" value="P_ac_wall_RPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033776934" evidence="3">
        <location>
            <begin position="31"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="792" mass="80044" checksum="A1EA4B565E1F72B8" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWH6</accession>
    <name>A0A2Z5QWH6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase PknA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86730">
        <property type="protein sequence ID" value="BAV86730"/>
        <property type="gene ID" value="RA11412_0431"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0431"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="113" mass="12537" checksum="10F64C220E897B07" modified="2018-10-10" version="1">MRPSADVTLGGRYTLTERIAVGGMGEVWKARDKVLGRIVAVKILKEEYTGDPGFLERFRAEARHTALLNHPGVANVFDYGEEDNSAYLVMELVPGSRYRTLLSVIALSQRIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWJ2</accession>
    <name>A0A2Z5QWJ2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">rsmG</name>
        <name evidence="4" type="ORF">I6I94_06180</name>
        <name evidence="5" type="ORF">NCTC10207_02422</name>
        <name evidence="3" type="ORF">RA11412_0473</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI25108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023133404.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86772">
        <property type="protein sequence ID" value="BAV86772"/>
        <property type="gene ID" value="RA11412_0473"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0473"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI25108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="211" mass="22818" checksum="47A6F1DBC45E585F" modified="2018-10-10" version="1">MEHTPLDGKNQVAAEQIFGDRLPLAQRYVEHLATSGIERGLIGPREVPRLWERHVLNCAVIQELISEGASVVDVGSGAGLPGLCLAIARPDLKLTLIEPLERRVNWLNEVVEDLGLENVTVFRSRAEQAVGAVEADVVTARAVSALVGLVDITLPILRGTGELLALKGRSAAEEVAKTKKKLNRYGARQTEILTVGEGLLDEPTTVVRIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWK7</accession>
    <name>A0A2Z5QWK7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCA tRNA nucleotidyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.72</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">tRNA nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_06220</name>
        <name evidence="4" type="ORF">RA11412_0461</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.72" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86760">
        <property type="protein sequence ID" value="BAV86760"/>
        <property type="gene ID" value="RA11412_0461"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0461"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014065">
        <property type="entry name" value="tRNA_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02692">
        <property type="entry name" value="tRNA_CCA_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HDc" evidence="3">
        <location>
            <begin position="252"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="474" mass="53658" checksum="F8AFAD19DB98127A" modified="2018-10-10" version="1">MSQKIDVLSKFPDAAQLGELYRRAGFELYLVGGIVRDQLRDTPGDFTDFDLTTDATPAESEQILRVWGEHVWDIGKEYGTISARKNGAVYEVTTYRAEVYASDSRKPTVEFGTDLRADLVRRDFTMNAMAASLPSGEVVDLFGGAKDLAEGVLRTPRSPQDSFSEDPLRMMRAARFAARFNLQVAPDVFEAMRQMASRIEIISAERVRDELVKLICADYPRVGLNLLVESGLADYVLPELPALRMEIDPAHHHKDVYGHSLKVMEQAIEKETGADGPCPKPDFVLRFAALLHDIGKPKTRRFEKDGSVSFLHHEVVGAKLVKKRMRCLRFDNDTISAVARLVELHMRFYGYREAGWTDSAVRRYVRDAGEQLQRLHRLSRSDVTTRNKRTARSLAQAYDDLERRIEELAAQEQLDAMRPELDGEQIMAVLGVKPGPVVGQAYRFLLNVRLDEGELGREAVTERLLTWWKEQQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWN8</accession>
    <name>A0A2Z5QWN8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86845">
        <property type="protein sequence ID" value="BAV86845"/>
        <property type="gene ID" value="RA11412_0546"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0546"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="92" mass="10500" checksum="8C033459633C3255" modified="2018-10-10" version="1">MILNQDTREVSRGGDPITLTATQFDLLRYLMENAKRVVSKSQILDNVWNYDFGGQANIVELYISYLRKKIDVGREPMIHTVRGAGYVIRPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWZ3</accession>
    <name>A0A2Z5QWZ3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86942">
        <property type="protein sequence ID" value="BAV86942"/>
        <property type="gene ID" value="RA11412_0643"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0643"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="192" mass="21163" checksum="BB59635A8D66C8AD" modified="2018-10-10" version="1">MPRLTEATKQARRRQIIDAAFTCFTAKGYTHTSMSDIIKESGLSSGSIYSHFDGKGDILHATVQQRIDMITAAYQELNTPSPRDIMRMIFSTSAVEANFTSMLRIRLEAFTVPEVQESTNTLLLPCTILLPSRSPLGVSSISRRKINANLLPTNCILSSATQRMRSSSLSRGLWCAQPCQPQPIGSISSTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWZ6</accession>
    <name>A0A2Z5QWZ6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86744">
        <property type="protein sequence ID" value="BAV86744"/>
        <property type="gene ID" value="RA11412_0445"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0445"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="141" mass="16226" checksum="E95E8EBA51551D8C" modified="2018-10-10" version="1">MQTDKHKLEIMQEAARILRTGGYYAIHELSLTPDYLRPEVQEEIQKDLARSIRVNARPLTVAEWTRIAEEAGFEVLDVYQTEMALLEPKRMIADEGIGGVAKIMFNLARKPQIRERVLGMRSVFRRHADHMGAIGLILRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX60</accession>
    <name>A0A2Z5QX60_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporting ATPase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_0662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86961">
        <property type="protein sequence ID" value="BAV86961"/>
        <property type="gene ID" value="RA11412_0662"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0662"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="4">
        <location>
            <begin position="30"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV86961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="183" mass="20029" checksum="243083183422D11C" modified="2018-10-10" version="1">MGNSTQTASTTTENERSLFDSSANGGQTRIIHLDVQGMTCASCVGRVERKLRKIPGVDPAVNLPLESARVIVPADITDEQIIETVNNAGYTASLKTKGHKTESEETTNARSGGLGWRIVVALLLSVPIFLISMFPTFQFPHWAGCLRLSRCRLRSIAPSRFTAPLSRTHATSAARWTRWFLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX67</accession>
    <name>A0A2Z5QX67_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mannose-specific IID component protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">PTS mannose/fructose/sorbose transporter subunit IIC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">PTS system mannose-specific EIIC component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">manY</name>
        <name evidence="9" type="ORF">I6I94_05965</name>
        <name evidence="10" type="ORF">NCTC10207_00033</name>
        <name evidence="8" type="ORF">RA11412_0515</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI21967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023133431.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86814">
        <property type="protein sequence ID" value="BAV86814"/>
        <property type="gene ID" value="RA11412_0515"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0515"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004700">
        <property type="entry name" value="PTS_IIC_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03609">
        <property type="entry name" value="EII-Sor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51106">
        <property type="entry name" value="PTS_EIIC_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VEI21967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="290" mass="30243" checksum="28B63FD8D2E638CB" modified="2018-10-10" version="1">MSPLAFILVIVVAFIAGVASVVDERQFHRPLVACTLMGFVLGDPGTGIIVGGTLELIALGWMNVGAAMAPDAALASTIAAVVVIHGHLDVAQGIAVAVPIAATGQVLTIFVRTITVFFQHQADRFAQTANFRGIELMHMSGMALQGLRVAIPTAVVSLINADTIKSWLDSIPGEITTGLRIAGGMITVVGFAMVINMMRSKALMPFFFLGFITAAAIPVSQTVKLNGVNTDVMGNLTATLTGQAQLDLVAIGIIGACLGLLYTQLNPIFHKSQAAPAAARPANDLDNELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX84</accession>
    <name>A0A2Z5QX84_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86936">
        <property type="protein sequence ID" value="BAV86936"/>
        <property type="gene ID" value="RA11412_0637"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0637"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="66" mass="7606" checksum="A9E7CAF460F13385" modified="2018-10-10" version="1">MSLLGMTVCILYSVDCARHMQDIKRQREYQRLAMQQAAAAYPAYGGGMVPQYTQVGYEQQPPHYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX91</accession>
    <name>A0A2Z5QX91_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkaline shock protein 23</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Asp23/Gls24 family envelope stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_05460</name>
        <name evidence="5" type="ORF">NCTC10207_00141</name>
        <name evidence="3" type="ORF">RA11412_0654</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037236574.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86953">
        <property type="protein sequence ID" value="BAV86953"/>
        <property type="gene ID" value="RA11412_0654"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0654"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI22075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="160" mass="17142" checksum="C15978A2688CE4DF" modified="2018-10-10" version="1">MSDNSIPQTGQQRERENNKETKQDKTPRGPLQTSHGVTTIEENVVAKIAGMATREVPGVYDMGNAVRRAFSAVTDRIPNAQTNVAGGISVQKGETQAAVDVTVVVEYGVSIVEVANAIRRNIIEQIEGTTGLEVVEVNIDVTDVHLPDDDSNSADSADLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXC1</accession>
    <name>A0A2Z5QXC1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinone oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05150</name>
        <name evidence="2" type="ORF">RA11412_0722</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87021">
        <property type="protein sequence ID" value="BAV87021"/>
        <property type="gene ID" value="RA11412_0722"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0722"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="12"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="328" mass="33665" checksum="9585D59B81370216" modified="2018-10-10" version="1">MMKAVQITSYDGPLGTLEYGETSDPTPAAGQIAINVHYAGASYVEALFAGGFVPTIPVPWVPGLEASGTVRAHGEGVTEHDGLEIGTPVAAFTVTDSGGYGQIAVTNAHLVAPIPEGLDAATAAAVPANTTAALIALERLAQVQSGQSVLVQAAAGGLGSQLGQVARYLGASRVVGVVGSEQKRHAALELGYDEVILRDDLAEQEPDQFDIIVDPVGGPTRARCVDLLRVGGRLLVVGDAAQAGDQLISSNDLWLGGKSVMGFNLGALTAAQPELVGTYLRRALQLVADGEVKVQVTDVVPITQAPSVLARLRAGSTVGKTVLKHEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXH4</accession>
    <name>A0A2Z5QXH4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="5">FGAR amidotransferase III</shortName>
            <shortName evidence="5">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">purS</name>
        <name evidence="8" type="synonym">yexA</name>
        <name evidence="7" type="ORF">I6I94_04615</name>
        <name evidence="8" type="ORF">NCTC10207_00319</name>
        <name evidence="6" type="ORF">RA11412_0849</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004006543.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87148">
        <property type="protein sequence ID" value="BAV87148"/>
        <property type="gene ID" value="RA11412_0849"/>
    </dbReference>
    <dbReference type="GeneID" id="29744066"/>
    <dbReference type="KEGG" id="raj:RA11412_0849"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PTHR34696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00302">
        <property type="entry name" value="TIGR00302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI22247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="83" mass="9190" checksum="7BD6C81BAE707BE7" modified="2018-10-10" version="1">MARIVVDVMLKPEILDPQGKAIAHELPRIGLNSFTDVRQGKRFELTVEGEATEEHLAQARQAAEELLSNPVIEDVVNVSVLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXJ2</accession>
    <name>A0A2Z5QXJ2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alkyl hydroperoxide reductase AhpD</fullName>
            <ecNumber evidence="6">1.11.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alkylhydroperoxidase AhpD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ahpD</name>
        <name evidence="9" type="ORF">I6I94_04970</name>
        <name evidence="8" type="ORF">RA11412_0764</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="Rhea" id="RHEA-COMP:16355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.11.1.28"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AhpD family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.28" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888559.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87063">
        <property type="protein sequence ID" value="BAV87063"/>
        <property type="gene ID" value="RA11412_0764"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0764"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008785">
        <property type="term" value="F:alkyl hydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032843">
        <property type="term" value="F:hydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01676">
        <property type="entry name" value="AhpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004674">
        <property type="entry name" value="AhpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00777">
        <property type="entry name" value="ahpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="7">
        <location>
            <begin position="97"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with AhpC); in linked form" evidence="6">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="176" mass="18743" checksum="BCD42E1F8A9382F0" modified="2018-10-10" version="1">MSIENLRNALPSYAKDMNLNLSSLPRITSLTEQQLWGAILATAAATKVDSVIVEIAAEAKEHLSDTAFDAALGAATIMGMNNIFYRTRGFLDGAYDDQRANLRMQIIGKNGGIDKLDFEMLALAVSAVNGCSHCVAAHEHTIREEGASKEQVNDLIRIAATLGGVAQGIQLAEALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXP4</accession>
    <name>A0A2Z5QXP4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PE_PGRS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87227">
        <property type="protein sequence ID" value="BAV87227"/>
        <property type="gene ID" value="RA11412_0928"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0928"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="442" mass="45488" checksum="E45C148B9E76615F" modified="2018-10-10" version="1">MDLAPCLHFDLEPGEDSAYGLRQYMHEVAPERAPRERAVEDITIPDGVSYMRFYIEGGQGGGVDMDDYSGGSGGYGAEVSGVIAVTPGQKYRFYLAAGGIGHYYEPADGGDGYTRGGSSALMPEYVYEDSDKERMTSADYNRLIIYSGSGGGSSALVLLDGDAETLIAVAGGGGGGGARGIIATSRTNLPDGAKMPTWRQFDPDVPKWAPRYSPPYLGNGGDGGESKASKPSKNAEEVYAQYGAGRIIAPSGATAGRNIGRGARGGSNPTFRSARGLSFTNTPQSQIRSRGVAGAAGGTGDFGHGGDGVAAYGYVTNIAATLPENAQTYDYNVAAYIVSGGGGGGYGGGGSGAAVVVGAQTTDQLANNSKPQTYAVSAGAVSGAGGAGGNYVNSNVLDAHVEMVGYSRGKNREEFTDGTAQYSFCPSRNNQIDHDGKMYPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXY7</accession>
    <name>A0A2Z5QXY7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpS</name>
        <name evidence="10" type="ORF">RA11412_1019</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87318">
        <property type="protein sequence ID" value="BAV87318"/>
        <property type="gene ID" value="RA11412_1019"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1019"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="181"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="2"/>
            <end position="3"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="181"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="320" mass="35290" checksum="B71A80167431C99A" modified="2018-10-10" version="1">MGNYIGAVGNWVKMQEDPKNECLFFIPDMHAITVPQDPAALRERTRVTAAQYIAAGIDPARSPFFVQSHVPEHAQLAWVLNCITGYGEASRMTQFKDKAQKQGTDNASVGLFTYPVLMAADILLYQADAVPVGEDQRQHLELTRNLAQRFNSRFGETFVVPEPAILKETAKIYDLQEPTSKMSKSATTEKGLIKILDDAKTTTKKIKSAVTDDGSVIAYDRETKPGVSNLLSIYSALTGESIDAIIARYEGKMYGHLKVDLAEVAVEKLSPMRERTLELVADPAELDRLLAIGAQKAREIATVTLENVYDRVGFLPALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY21</accession>
    <name>A0A2Z5QY21_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_04385</name>
        <name evidence="2" type="ORF">RA11412_0911</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888264.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87210">
        <property type="protein sequence ID" value="BAV87210"/>
        <property type="gene ID" value="RA11412_0911"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0911"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="222" mass="23218" checksum="54287EA01F560566" modified="2018-10-10" version="1">MLPKQPTPEELRLWPDALRAIAVQLDAGLSQAQAIAGALTRIASDRAEHSPAAPAQLSWFARRGYRQATQDIATLFTALGANAELGLPLSQACQQWVHTHTGTARQHSVQRVNELLVCLHLSEATGSALSATLRRAAEHAEESIDALLGRESALAAPRATGRILSLLPFIGLGLGELMGTSPVSVLTGSIAGACAGLVGVGLALAGRRWTAALVHAAETETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY40</accession>
    <name>A0A2Z5QY40_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_04315</name>
        <name evidence="2" type="ORF">RA11412_0931</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87230">
        <property type="protein sequence ID" value="BAV87230"/>
        <property type="gene ID" value="RA11412_0931"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0931"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="257" mass="27708" checksum="4C8D0847183D74B8" modified="2018-10-10" version="1">MSAPEWAELNPADKHLARIIAHARVLRDPVFSHRSAAIIHGIQTLSVPDKLQVLGSGGATNSGLQYRQDEPSHRATILTGPGGLRVVDPVAATIGSVRDTNFAEAMVIAESALRSFPELTHTELHDSLMAVRRSRGSKNAHRVAAAMSSLSASPAETLARVALLNLGLEPVQQYQISTPLQTFRVGAALVEHGVVVEVVGAPGHAPPQDVSPQDTPAQKAREEAIRGEGWDFVHLTWADVRYRPDAVERKLHRKGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY72</accession>
    <name>A0A2Z5QY72_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acetylneuraminate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87408">
        <property type="protein sequence ID" value="BAV87408"/>
        <property type="gene ID" value="RA11412_1109"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1109"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="97" mass="11337" checksum="834CE700A105970A" modified="2018-10-10" version="1">MGPFVWRWYPDAEPTAEFEVMARPRRQELTKETYRYRENGSMYITKTRVYTEHHNRLAGYPGGSIDLFILDEIEGVDIDAPIDFSVAEHQLAQILES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY98</accession>
    <name>A0A2Z5QY98_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87445">
        <property type="protein sequence ID" value="BAV87445"/>
        <property type="gene ID" value="RA11412_1146"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1146"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="135" mass="13845" checksum="291DA2EA5E83BA20" modified="2018-10-10" version="1">MSTPARPATRPGFAETLTALERAQKPGHGVPAYTRWVNRRVARYFAAAAVAMGITPNGVTAISAVCSAAGILTLLLAPPTALTALAVALLFALGYGLDSADGQVARVTGASSPPGNGLTMWLIQSVYPASTLPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYD1</accession>
    <name>A0A2Z5QYD1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03390</name>
        <name evidence="4" type="ORF">NCTC10207_00592</name>
        <name evidence="2" type="ORF">RA11412_1176</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888105.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87475">
        <property type="protein sequence ID" value="BAV87475"/>
        <property type="gene ID" value="RA11412_1176"/>
    </dbReference>
    <dbReference type="GeneID" id="32323520"/>
    <dbReference type="KEGG" id="raj:RA11412_1176"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI22514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="165" mass="18900" checksum="22D531A5FA744365" modified="2018-10-10" version="1">MKFRGKLLPAERTIVITRTHPIKLLPVLGYAMLAACAWSFGSAARSSNLLAWLGVILSFISIIVAVRKLLYWLGRRYIVTTHRLMMTNGLLSMRATQGMRLDQMGRRWKRQGQMGKWLGYGSVQVELLGTSIPLTYVPEPDKFLRIMEHSVRTYYPLRAGYMRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYF8</accession>
    <name>A0A2Z5QYF8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">dusB</name>
        <name evidence="14" type="ORF">I6I94_03260</name>
        <name evidence="13" type="ORF">RA11412_1206</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87505">
        <property type="protein sequence ID" value="BAV87505"/>
        <property type="gene ID" value="RA11412_1206"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1206"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="12">
        <location>
            <begin position="26"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV87505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT89641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="388" mass="42285" checksum="DDFC27D0E5A2E976" modified="2018-10-10" version="1">MNSEASHLKLPPLKLGKLTVETPVVLAPMAGVTNKAFRRLCREYGGGLYVTEMVTARALVERKPESMRIIEHDADEQIRSIQIYGVDAVNVGKAIRLVVEEDRADHIDLNFGCPAPKVTKRGGGAALPWKTDLFTAIVHTAVKEASRNDIPLTIKMRKGIDDDHITFLESAKIARDAGVAAIALHGRTAAQHYSGTADWDSIAQLREAIPDVPILGNGDIFAAEDAVRMVEQTGVDGVVIGRGCQGRPWLFGDLQNAFEGSSERIRPTLSEVAAMIYRHAELLVETFADEYKGLREIRKHVAWYFKGYPVGGELRAKMATVPDLETFRELLGQLDHSIGYPGAAVEGSRGRAGSPKKPHLPDGWLNSRILGDAERLGLVEAELDISGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYG2</accession>
    <name>A0A2Z5QYG2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87350">
        <property type="protein sequence ID" value="BAV87350"/>
        <property type="gene ID" value="RA11412_1051"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1051"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="51" mass="5653" checksum="AE7458AD0EC2D3A0" modified="2018-10-10" version="1">MNSSRVPVGWTEVEIPPNTAEQGNERVSRHSVSLRILSEATTVTVDSCRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYH2</accession>
    <name>A0A2Z5QYH2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87360">
        <property type="protein sequence ID" value="BAV87360"/>
        <property type="gene ID" value="RA11412_1061"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1061"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4951" checksum="FB4BC30CC039A1F0" modified="2018-10-10" version="1">MSGRERPAHICLLEAFIGFTLLPLRKQMYNQLRYRRYFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYI6</accession>
    <name>A0A2Z5QYI6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_04025</name>
        <name evidence="1" type="ORF">RA11412_1005</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87304">
        <property type="protein sequence ID" value="BAV87304"/>
        <property type="gene ID" value="RA11412_1005"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1005"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="182" mass="21585" checksum="C7869208FC8C3BD4" modified="2018-10-10" version="1">MKQPYEISSDFFKKMTSSGWYFERDVLLEKLPPHLEELPDLVKKFLREIWYISVAKDMYIPVEYEMFMFDNEVYTFGETTQELIDYSLEENSSDYFCPHLIDKKIRNFGFKEGRDILIDELGRIYEIPDSGDIYYVGGKFYEGLYNLIYSRGESYIVSDTGELFKETQEGIMSANMNIEDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYJ4</accession>
    <name>A0A2Z5QYJ4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">dTDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">dTDP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_1124</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87423">
        <property type="protein sequence ID" value="BAV87423"/>
        <property type="gene ID" value="RA11412_1124"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1124"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="182" mass="20472" checksum="7E14320EDEB6BDB2" modified="2018-10-10" version="1">MLGDNIFYGHGLGTQLAKYEQKDGATVFAYQVADPRAYGVVEFDENNNALSIEEKPEKPKSDYVIPGLYFYDRDVVNYAQELEPSPRGELEITDLNRVYLKQGKLKVEVLPRGTAWLDTGTFDSLADATNFIRTVQKRQGLSIGCPEEIAWRAGWLSDQELSKIASPLVKSGYGEYLLNLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYZ0</accession>
    <name>A0A2Z5QYZ0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding S4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03275</name>
        <name evidence="2" type="ORF">RA11412_1202</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888225.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87501">
        <property type="protein sequence ID" value="BAV87501"/>
        <property type="gene ID" value="RA11412_1202"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1202"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="1">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="70" mass="7817" checksum="FD4DDEB0C25431B5" modified="2018-10-10" version="1">MEKIYIRDEMIRLGQFLKLANLVEDGAQAREVIQHGLVKVNGQIEEARGKQLHPGDTVSFNGVSVQVARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ15</accession>
    <name>A0A2Z5QZ15_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87531">
        <property type="protein sequence ID" value="BAV87531"/>
        <property type="gene ID" value="RA11412_1232"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1232"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025289">
        <property type="entry name" value="DUF4081"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13312">
        <property type="entry name" value="DUF4081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF4081" evidence="1">
        <location>
            <begin position="85"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="253" mass="27620" checksum="12EBA0B54C02802C" modified="2018-10-10" version="1">MLPKLFTAASASQSVPRRAIPLDVRHADALEEALYSSIVGNLYAVDFYEQVGLPMAGSVGDKVPSGYAGFVGIPAEGDERDGAQQPNLSSIILLGNNTVPVVVANSDYAVLAKCIHRSKRRLDSIFGPADMVNPLWHTLESRMPAPSSYRPIQPLLYLSPEVDLTEHIDATLPRIPTHLPPLATTDLYDQQVGHYVRFANSADYNALLPAAAAMFREEVGLDPLERYGQGYRNRVHTLSAQQRTVVATNVEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ17</accession>
    <name>A0A2Z5QZ17_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FTR1 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Ferrous iron transport permease EfeU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_02850</name>
        <name evidence="8" type="ORF">RA11412_1304</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87603">
        <property type="protein sequence ID" value="BAV87603"/>
        <property type="gene ID" value="RA11412_1304"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1304"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="314" mass="33831" checksum="A4B2D6261853E6E1" modified="2018-10-10" version="1">MNFWAAFTGNFLIGLREGLEAALVVGILIAYIHKTQRTHLLPKVWAGVAFAVVVSLGFGALLTYGPKTLTFEAQEAIGGSLSIIAVGFVTWMIFWMAENARALSTELHTKLDAVQGSTWAVVLLAALSVGREGLETTLFIWSATQAATAEQDSADSALPVYGALTGIIVAVLLAWAMMRGIMKINLAKFFTWTGAFLIIIAAGVLSYGLHDLQEANILPGINNIVFESYKYIDPGSFLGTMLKAVFNLSSTTTWIEAIAWVLYVGIIMTLFFRVQLRHRRVRQSSAPKNVAAAANSTPENGGTTTTQPLSNGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ95</accession>
    <name>A0A2Z5QZ95_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tyrS</name>
        <name evidence="10" type="ORF">RA11412_1322</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87621">
        <property type="protein sequence ID" value="BAV87621"/>
        <property type="gene ID" value="RA11412_1322"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1322"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="244"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="406" mass="44795" checksum="C08263BD7D97E9F2" modified="2018-10-10" version="1">MSADILNAQHNDDTFENIWQELKWRGLVHVSTDEEALEKALSSETVTFYTGYDPTAASLHLGHLVQLLVMRRLQLAGHKPIGLVGGFTGLIGDPRQTSERVLNSREVVAGWVDSLRSQIERFLSFEGENGARMVNNLDWGGQLSAIDFLRDVGKHFRVGTMVKKEIVAKRLNSEEGISYTEFSYQILQGLDYLELNRQYGCALQTGGSDQWGNLTSGTELIRKVEGKTVHAIGTPLITNSDGTKFGKSEGNAIWLNPQMCSPYAFYQFWLNTADADVVDRLKVFTFLTRAEIGEYEHKVETEAYKREAQKRLAYEVTALVHGVEATHQAIAASEALFGKGDFAALDESTLQAVMSELPSVELSSDQLDLITVLTELGFASSKSEARRILKEGGASVNGAKVQGRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZA0</accession>
    <name>A0A2Z5QZA0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87696">
        <property type="protein sequence ID" value="BAV87696"/>
        <property type="gene ID" value="RA11412_1397"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1397"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="38" mass="4111" checksum="D3F6D3A429263CD9" modified="2018-10-10" version="1">MNDSKATNPHAANASMSAYPSLVWIAGACRRVSPMMSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZK8</accession>
    <name>A0A2Z5QZK8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87796">
        <property type="protein sequence ID" value="BAV87796"/>
        <property type="gene ID" value="RA11412_1497"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1497"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="76" mass="8966" checksum="D3CA89DAA342A612" modified="2018-10-10" version="1">MFIIIGLFYALGKDIDKENAQLKLARNFEEDILKIDDRSVHSLFYRNYIFAIENAELPTHFTPMDYVTTGRHFIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZL2</accession>
    <name>A0A2Z5QZL2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I6I94_02050</name>
        <name evidence="11" type="ORF">RA11412_1504</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037235502.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87803">
        <property type="protein sequence ID" value="BAV87803"/>
        <property type="gene ID" value="RA11412_1504"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1504"/>
    <dbReference type="UniPathway" id="UPA00253">
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="9">
        <location>
            <begin position="151"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV87803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT89434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="432" mass="45999" checksum="647D0359805BC104" modified="2018-10-10" version="1">MATTSLLTDHYELTMLQAALASGAAHRMCTFEVFTRRLPAGRRYGVLAGTGRFLEGLDKFRFDDEELSFLAARNIVNTQTLKYLENFEFTGTVRGYAEGELFFPHSPVLQVEATFAQACVLETYLLSILNYDSAVASAASRMSAAAGTRPCIEMGSRRAHERAAVSAARAAAIAGFAATSNLEAGRRYGLETVGTSAHAFTLLHDSEREAFEAQLRSLGARTTLLVDTYDVDNAVRTAVELAGEELGGVRLDSGDLVATAQRVRELLDSLGNEHTKITVTSDLDEYAIASLAAAPVDSYGVGTKLVTGSGAPTSSMVYKVVARENSAGEMEPVAKASAGKASVGGAKRAARKLSPMGIASAELLSITEDPAQVENTRPLMVDFVVDGEHLPGFTGEDAVRAAAARHQRSLAELPEAARRLSEGEPVIPTEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZN1</accession>
    <name>A0A2Z5QZN1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87823">
        <property type="protein sequence ID" value="BAV87823"/>
        <property type="gene ID" value="RA11412_1524"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1524"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="56" mass="6384" checksum="C4AD05273370C762" modified="2018-10-10" version="1">MEDQRSKYRQVSTLLAQYMPGVPLMNVTSNVALSRDVRGYVTEQNAIEYFTKITVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R038</accession>
    <name>A0A2Z5R038_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87906">
        <property type="protein sequence ID" value="BAV87906"/>
        <property type="gene ID" value="RA11412_1607"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1607"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="375" mass="41369" checksum="98692231CF464908" modified="2018-10-10" version="1">MYYAVGLAGEHGYSRTRTLWQVGANPLFIASFVSSGHNDSMMTLFMVASLYIAKRHRTFWGGMAAVTVLALGVAVKPLALVVLPFVGLLWAGEYASWPRRFVYWALSLVVLFTEMWLMGAVTGLGFGWVSALSTTAGQFIWFTPLGLVIGAVVTAPGVSPETADHYKHIIEYIGKGLGMAGAILFAFFGRDREIVRRAGLAIIVMLVLSPMIQPWYLLWALPMIAATGIRTNFQLMWYFATTVFFMALSVSDQLAISPYLLDFDKHMAQLIAGLVCLGYVLYLLLLDPGTHALTRNTLMPKMLLAHIPRWSMRTRMNLKRAKAEYAAAKLLRSEQKKQRVAKAPSASQQAHKADASGKQQEGQADTSVHNNNSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R073</accession>
    <name>A0A2Z5R073_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87941">
        <property type="protein sequence ID" value="BAV87941"/>
        <property type="gene ID" value="RA11412_1642"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1642"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="39" mass="4726" checksum="D9E3F36791806CFC" modified="2018-10-10" version="1">MMHSSSVKIRKRHIIRVGDMFYMNNKFKGKLLPKPLYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R081</accession>
    <name>A0A2Z5R081_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prokaryotic ubiquitin-like protein Pup</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Bacterial ubiquitin-like modifier</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pup</name>
        <name evidence="7" type="ORF">I6I94_00740</name>
        <name evidence="8" type="ORF">NCTC10207_01159</name>
        <name evidence="6" type="ORF">RA11412_1843</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic ubiquitin-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887166.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88142">
        <property type="protein sequence ID" value="BAV88142"/>
        <property type="gene ID" value="RA11412_1843"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1843"/>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008515">
        <property type="entry name" value="Ubiquitin-like_Pup"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05639">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03687">
        <property type="entry name" value="pupylate_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI23062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="64" mass="6951" checksum="F4336FE97A0F5F15" modified="2018-10-10" version="1">MSRERMSASEPLGQEQAQEQELTLASHSAVQDVSEVDDLLDEIDGLLAENAEDFVTGFVQKGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R094</accession>
    <name>A0A2Z5R094_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87940">
        <property type="protein sequence ID" value="BAV87940"/>
        <property type="gene ID" value="RA11412_1641"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1641"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="59" mass="6428" checksum="3B2F2F10B1F64543" modified="2018-10-10" version="1">MPSFQRFGVSFIDTDFFVAYRTTNGEVLPVEELADEVDTNSLETLNSIVAAAKNKAGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0D2</accession>
    <name>A0A2Z5R0D2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87980">
        <property type="protein sequence ID" value="BAV87980"/>
        <property type="gene ID" value="RA11412_1681"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1681"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021904">
        <property type="entry name" value="DUF3516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12029">
        <property type="entry name" value="DUF3516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="117" mass="13407" checksum="1567EA6E0B42168F" modified="2018-10-10" version="1">MMVRNALFRRVELFADERDRILGELDEVSGWDADAWADAMDDYFDAYDDIYTDAEARSPKLVQIDDNVREHPGIWKVQQTFADPEDNFDWGIRAEVDLAASDDAGYPVLKILSVGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0E6</accession>
    <name>A0A2Z5R0E6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88021">
        <property type="protein sequence ID" value="BAV88021"/>
        <property type="gene ID" value="RA11412_1722"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1722"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="56" mass="6317" checksum="CF35BAC365E9A6C9" modified="2018-10-10" version="1">MSVEIPEVLRPKMKGSTVLAKSLRALEKLQPHPTELAEQARDQAQELLDQHRCAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0G4</accession>
    <name>A0A2Z5R0G4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_1909</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88208">
        <property type="protein sequence ID" value="BAV88208"/>
        <property type="gene ID" value="RA11412_1909"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1909"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="97" mass="10495" checksum="93943CD7CD1D3276" modified="2018-10-10" version="1">MQATQTMQENLRAGDEIMTRAGLYGTIVSTDHENRKALVEIAEGTIITISLDAVATVVDVAEEEPVEAKEEVVESTEGKDTAEDESPEKPAKGYDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0K2</accession>
    <name>A0A2Z5R0K2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88258">
        <property type="protein sequence ID" value="BAV88258"/>
        <property type="gene ID" value="RA11412_1959"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1959"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="90" mass="9287" checksum="EE6BFE5EF779AEF1" modified="2018-10-10" version="1">MSQKPEDSPKESTAAPDTATGASAPPPPHTTGASQERTILALKVAAIVIVTLAIWFIPAPPGVDPRGMHMAAILLAPSWVSSSSRCPPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0L1</accession>
    <name>A0A2Z5R0L1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_00615</name>
        <name evidence="3" type="ORF">NCTC10207_01180</name>
        <name evidence="1" type="ORF">RA11412_1874</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887219.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88173">
        <property type="protein sequence ID" value="BAV88173"/>
        <property type="gene ID" value="RA11412_1874"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1874"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI23083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="119" mass="13640" checksum="E4051A7A0FD4BB5F" modified="2018-10-10" version="1">MPLSPLTEQARADAREKALLARTHRQEIKQALTNRELTVRQVLDMIDTDPALAKMPVGQMLRALPGIGAVRATKIISELEIAPTRRLGGLGVHQRRKMVEYFNRHTRYFDRARRVKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0L3</accession>
    <name>A0A2Z5R0L3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88024">
        <property type="protein sequence ID" value="BAV88024"/>
        <property type="gene ID" value="RA11412_1725"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1725"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="315" mass="35544" checksum="175210DF1E0AED8F" modified="2018-10-10" version="1">MREFRYSLGYSCVRQLSDVPGDYPAPKLFKKLPQGFTGYRHEFHTDPQTGETIQPYQVEHTGSLGRQKPRIEKTTTNYRGPAGLCQEQIDCLEHPENLVFEPIPHAEESTWTRRVEPLTYRPRPHNMYDQAYAEAPNDSLMMWLIEDHELPTAQMPFAQAALNTAGIPEEFMHRAVQAIDDFHRTLMQWYAWLLQNNPNTLAAQSMPFVTTAGFQKHVKGLETILDTITHTHQVLQEPAYSVLGWLTGAAAAEHRALTAESIAALAGRGMLDASLLADELAYLLRGDGLNRPGQPAVYRTPHLSAHWRGGVLCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Q1</accession>
    <name>A0A2Z5R0Q1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I6I94_00045</name>
        <name evidence="11" type="ORF">RA11412_2019</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88318">
        <property type="protein sequence ID" value="BAV88318"/>
        <property type="gene ID" value="RA11412_2019"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2019"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="92"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="368"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="403"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV88318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT89077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="617" mass="66188" checksum="DF47778384E14D91" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0R3</accession>
    <name>A0A2Z5R0R3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88130">
        <property type="protein sequence ID" value="BAV88130"/>
        <property type="gene ID" value="RA11412_1831"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1831"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="46"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="262" mass="28748" checksum="9250D03FB83ED42C" modified="2018-10-10" version="1">MPNNENTSYAAQYQAAQQRAAHAKTALAAFEKNLGFPLDDFQQSACRSVESGRAVLVAAPTGAGKTVVGEFGIYLALRKRLKAFYTTPIKALSNQKYHDFVREYGEETVGLLTGDTSINAEAPVLVMTTEVLRNMLYADSPTLEGLGYVILDEVHYLADRFRGAVWEEAIIHLPEHVTVISLSATVSNVEEFGAWLDTVRGGTDVIVSEHRPVPLWQHMLVGNQIVDLFTPDPEEKRASGARRATKRPKKTPTSTPHPPGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0S4</accession>
    <name>A0A2Z5R0S4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86469">
        <property type="protein sequence ID" value="BAV86469"/>
        <property type="gene ID" value="RA11412_0170"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0170"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="229" mass="25008" checksum="E431A0EEE223D265" modified="2018-10-10" version="1">MARALTAFNRVRAAHPGKNIVVATHGMLIAVTMTVLLEHEHPEALTVDGIYPIPPNASITQLPTALLDAAIDRHVVTHSEGDVGPEPLPEGLAGGTLTLIRHGQTDWNKNRLMQGVSDIPLNETGRQQAHETGAKLQQMGLSYDRVLSSPLSRAHETAQRVGEFFGLTVSQTYPELVERAYGAAEGKNIPDYESDAPDRFYPGVETERDLYVRAVRALREVVRQYPGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0T2</accession>
    <name>A0A2Z5R0T2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-formylglutamate deformylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86479">
        <property type="protein sequence ID" value="BAV86479"/>
        <property type="gene ID" value="RA11412_0180"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0180"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="220" mass="23171" checksum="4E9B9F87438F0532" modified="2018-10-10" version="1">MGHPLHPDLEERLTGLSAHDVAAALAEFTYAGDMTDTAAYSAHVQATLGELLEIEAQVISAGVELIPGAQRFLGYLSEHMPVAVASNSTAQILDVKMRTYGYAPLVRTWVSSEDVPHGKPAPDMYIEAARRLGCDPADALTVEDSAAGAQAARDAGTKVLIYVPDGDTASAPAGYGYFESFTDPALWDAARIWVAALEGARAAEGAHSPEDEPPLVEAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0U2</accession>
    <name>A0A2Z5R0U2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MmcQ/YjbR family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_11210</name>
        <name evidence="1" type="ORF">RA11412_2058</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88357">
        <property type="protein sequence ID" value="BAV88357"/>
        <property type="gene ID" value="RA11412_2058"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2058"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35145">
        <property type="entry name" value="PTHR35145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="137" mass="15704" checksum="897068DC969D5432" modified="2018-10-10" version="1">MGTPNSREITAEDLHEVVDQIALTMPLATSDQPFGPRNTVYRISGKIFAMYTDGIGYPIVNLKTDPEESEVLQRMYPSIIPGWHMNKRHWISVGAGKGVTRQLLEELIEDAYLRIMYALPKVKRPIEFRERPVPEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Y9</accession>
    <name>A0A2Z5R0Y9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rpsT</name>
        <name evidence="10" type="ORF">I6I94_00715</name>
        <name evidence="11" type="ORF">NCTC10207_01164</name>
        <name evidence="9" type="ORF">RA11412_1852</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023133056.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88151">
        <property type="protein sequence ID" value="BAV88151"/>
        <property type="gene ID" value="RA11412_1852"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1852"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VEI23067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="87" mass="9672" checksum="A427057EAE858853" modified="2018-10-10" version="1">MANIKSQKKRILTNEKARLRNNAIKSELKTATRKVKEAVEAQNKEAAEEALRFVSRKLDKAASKGVLHKKNAANKKSGLAKLVNKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Z1</accession>
    <name>A0A2Z5R0Z1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC iron siderophore transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88408">
        <property type="protein sequence ID" value="BAV88408"/>
        <property type="gene ID" value="RA11412_2109"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2109"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin_N" evidence="2">
        <location>
            <begin position="59"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="341" mass="37401" checksum="E8F25B6CAA812CDD" modified="2018-10-10" version="1">MQHTDYTHLMRVRELLAHCDVPLETLNADLARERIRAANKQLDDYILPRAGSLDAPLTVVVGGSTGAGKSTLVNSLLGEPLTRAGAIRPTTRQPVLLHRSEDAPYLGSEHYLPSMRHHSVAAGETVPGADAHTEADVLVTLQTQTVPPGIALIDAPDIDSVSEQNRRLAKDLLSAADLWLFVTTANRYADAVPWELLHRAAERNITVAVVLNRVPEGAEHEIEEDLQHMLSEAGITPALLVSIPEQKRDNRGLLPPAAIGQVRNWLEQLGQTHRHARQSPAVPSAALLTGWAKTCRLLPQNKNPSTRRSPGSAPQWMTPTTPHWRTSVRQPPTVRYCAVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R100</accession>
    <name>A0A2Z5R100_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6318 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88418">
        <property type="protein sequence ID" value="BAV88418"/>
        <property type="gene ID" value="RA11412_2119"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2119"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046281">
        <property type="entry name" value="DUF6318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19843">
        <property type="entry name" value="DUF6318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6318" evidence="1">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="123" mass="13757" checksum="39B913B1E9414543" modified="2018-10-10" version="1">MAWFGAAVDYLLQTGDMQYVNTVTLNTEAKNVLQGYAESTKKSEADKIWYAKPSASLIITAPQPVYAGGSWNWQVKLNIDVGEKIYRKGTLQDTPADKRHIYMSGEAVGTYMNGIWDLNMDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R104</accession>
    <name>A0A2Z5R104_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cys-tRNA(Pro) deacylase YbaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88465">
        <property type="protein sequence ID" value="BAV88465"/>
        <property type="gene ID" value="RA11412_2166"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2166"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="60" mass="6498" checksum="364A4B0D58F22BD7" modified="2018-10-10" version="1">MAKKNKGGKKGASTAAVALLKETETPFEIREYEHAEGETSFGLEAAQKLGADPSRCLKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R112</accession>
    <name>A0A2Z5R112_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="11">RNAP omega subunit</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoZ</name>
        <name evidence="12" type="ORF">RA11412_1872</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88171">
        <property type="protein sequence ID" value="BAV88171"/>
        <property type="gene ID" value="RA11412_1872"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1872"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34476">
        <property type="entry name" value="PTHR34476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV88171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="166" mass="18072" checksum="CBA81B5BC777BA05" modified="2018-10-10" version="1">MSALKKNTTYIGVSVANETKEDYNFVDGTAPEGIVNPSADALIEKAESKYGLVIFGARRARQINAYYANLQENTGEHVGPLVDSEPNDKALSVAMREIMSDQIVAEHIPDGRFDENGQLVHEDFSAAMLGIDEADFMSTAVEEEYIPAGTEEVIAIEEVVLDDSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R129</accession>
    <name>A0A2Z5R129_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="10">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 14" type="primary">alaS</name>
        <name evidence="14" type="ORF">I6I94_00530</name>
        <name evidence="13" type="ORF">RA11412_1892</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88191">
        <property type="protein sequence ID" value="BAV88191"/>
        <property type="gene ID" value="RA11412_1892"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1892"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="12">
        <location>
            <begin position="1"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="748"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="681"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="685"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV88191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT89160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="893" mass="97235" checksum="0756C1B5963E9525" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R146</accession>
    <name>A0A2Z5R146_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted D-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88226">
        <property type="protein sequence ID" value="BAV88226"/>
        <property type="gene ID" value="RA11412_1927"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1927"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="132"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="234" mass="25790" checksum="FE14BB4DDA301920" modified="2018-10-10" version="1">MTRYAPQAFIRLCERAGVKYRIPDNIGEMCCSTPWKSKGFTDGYSIMSDRVLKSLWEATDGGRLPVVCDASSCTEGLNVMREKVIKALEHKIVNGLKPGEPDFSRLRMYDAVQFAADNMLDKLTVSAPLPSIALHPTCSMTHLGTQPAFEKIANAMSADVYVPKHWGCCGYAGDRGMLHPELTASATEAEAAELSEQKQFAAYISANRTCEQGMTEATGHTYQNVLQLLERTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R155</accession>
    <name>A0A2Z5R155_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88236">
        <property type="protein sequence ID" value="BAV88236"/>
        <property type="gene ID" value="RA11412_1937"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1937"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="92"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="4">
        <location>
            <begin position="357"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="473" mass="50015" checksum="10FA5BD94C5A7EF5" modified="2018-10-10" version="1">MISSGRHMRSSIMKSARNKWIALFSACMLLVVLGFGGAIALRLRANLHTNELNIGDYQGALENGALDILVIGSDTRAGTDGSYGEDDGKAARADVMMLLHISKDRKNVNVLSFPRDLMVSIPKCTDPDGKVYPAEDGVQINESLGRGGPGCTVATISKLTGVQIDHFMLVDFNAVKELSKVVGGVEVCVDKPIDDEYTNLKLPAGRSTVEDEQALAFLRSRHGFGDGSDIGRIQAQQGFMAALLRKVKAEGTLSNPSRMVNIAEAITQNVTVDKGLGNINELVGIGGTLGGVDLSQVVFATVPTEPWSQDNNRLQVTSEANSVFKRLQDDQSLKVEKAAPAAQEQPKEQSAPADHSTNVTVVNATNLEGRGAAISQVVSGLGYTNVAPTSAAEAAQFSAVTYAAGHEAEAREIAAKLNIGRVSESAEATGVTVTVGTDFPKGETMEKQEAQIAGNANGQTADQETCQHAFAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R177</accession>
    <name>A0A2Z5R177_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-isopropylmalate dehydratase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_2104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88403">
        <property type="protein sequence ID" value="BAV88403"/>
        <property type="gene ID" value="RA11412_2104"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2104"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="5">
        <location>
            <begin position="54"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="347" mass="37846" checksum="60F4536B8621086A" modified="2018-10-10" version="1">MIVCGYGHTFSVSQNVEDTLYCVDSPSKQNHDEYTPNTNRRKMVTHPGPRTLAEKVWDSHVVVPGENGKPDLLYIDLHLVHEVTSPQAFEGLRIENRPLRRLDLTIATEDHNTPTENIFSTIADITSRTQIETLRRNAAEFGMRIHPLGDKEQGIVHVVGPQLGLTMPGLTVVCGDSHTSTHGAFGALAFGIGTSEVEHVMATQTLPLARFKTMAINVEGTLKPGVTAKDIILAVIAQIGTGGGQGYVLEYRGSAIHSLSMEGRMTICNMSIEAGARAGMVAPDETTFEYVKGRPHAPTGQDWDEAVAYWKTLPTDEGPSSIKKSTLMRMSWSLSSPGALTRDRVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1D6</accession>
    <name>A0A2Z5R1D6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasmic axial filament protein CafA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88304">
        <property type="protein sequence ID" value="BAV88304"/>
        <property type="gene ID" value="RA11412_2005"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2005"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="171" mass="18883" checksum="1A14D37FE38469F4" modified="2018-10-10" version="1">MAEEMNANESGLNMGVLADIASLASEKNVSDETVRSLNEKVPGADKADQAEKKRGRGSSKKSTVSRRSKAESGSKDSEELSPERAVAESLSDLRNLKAKHAPAPKNLPNQLRRMRSRALSIEFLKALMMPPIAPNPLRMRQQLSSRPPFCRIQSRELIKISPPQNLKLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1G3</accession>
    <name>A0A2Z5R1G3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_11320</name>
        <name evidence="2" type="ORF">RA11412_2035</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888321.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88334">
        <property type="protein sequence ID" value="BAV88334"/>
        <property type="gene ID" value="RA11412_2035"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2035"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="95" mass="10801" checksum="94AFCDC7E8EA721F" modified="2018-10-10" version="1">MYSFEITLLIVHAAIVGFCLWHLTTRTRYSEARLNFVLPLILFVPGTGLLYLLAARAGTVPPDSTKTGSSSRHFEHRLGFRDGERSKWGLPRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1H5</accession>
    <name>A0A2Z5R1H5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent DNA helicase SCO5183</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88635">
        <property type="protein sequence ID" value="BAV88635"/>
        <property type="gene ID" value="RA11412_2336"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2336"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="265" mass="28447" checksum="A62222233A189AAC" modified="2018-10-10" version="1">MAAARAEAQTDTSRSLGTLIHAIAEEYPAADYATLSAVLQERLITLALPETWEGEETRRRAEKMIQKLAVYFKEIMPGDGRTLVGVEGAFKVRVPGEKLDAQISGRVDRLEVTEDGRYMIVDLKTGRTKPAKADIAQHAQLAAYQVAVEAGAGDTMSRELGTEPAAHPGGTPGGSDDNVYRAMGRRSAGAALVQLGDGTAPTAKNRPQEQPPLDPDSDEWAVELIRCAAELIAGALIQARHRPGEKCRLPEICPLCPQGRQVTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1H6</accession>
    <name>A0A2Z5R1H6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88587">
        <property type="protein sequence ID" value="BAV88587"/>
        <property type="gene ID" value="RA11412_2288"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2288"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="410" mass="43829" checksum="112F1CF3A5A24B90" modified="2018-10-10" version="1">MKYSLFLADAPRTLGKPDYPSYPQLLSVECAAGSQARQLAQALPHSALTVAGRPLETLTVGATPLTPGACLEPGRTQLTQPAAVSTLYVLRGPDAGHAYPIPRGHTRIGRSQKNNQAVALNDPYLAPNHGTLVVDGSGARLILSHPPRSKNLAALPLPHGVLPGASNNKEQEIRWNEPFIVGSSTCLLTAPGQSPALPQSTGSPFEPVTSHTQAARKLGTLIIMVCLPLIIGVAVATLTGMWMFLLMSLASSALMLLHMLSGRGENKRAQREVHNSGEREKLRAEGLTPAGARPFIPAANQSAAAAIVLGVGTRLPFVSGRNLNVSSLQPHKRAPHYVPVPTAALPHELHLKPEHLHAYLVQLVAVYPGEIIVLAPHPQQQLCVMRWYALEFTNGCACALVLSRSLKHWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1N2</accession>
    <name>A0A2Z5R1N2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpf</name>
        <name evidence="5" type="ORF">RA11412_2299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88598">
        <property type="protein sequence ID" value="BAV88598"/>
        <property type="gene ID" value="RA11412_2299"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2299"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="4">
        <location>
            <begin position="185"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="241" mass="26687" checksum="524F91910D017A55" modified="2018-10-10" version="1">MGARNLKDGFPVPNPTGCGTKPPNRRESIVEVNIYGRNIKVSERLHDYVEDKVQKFEKLGDNVSDIDVKFTKDGHLGGNVIRVEITVIGRGPVLRAESQGPDKFAVFDETYGKLLERLRRARDRRKLRKHGGKHPVSVADATGSIPVVGKTAITEILLPDVPVEEAAFDTTEVTLSDEAASPLEIRHKSFPGERLSPAEAVDHMELVGHDFYLYIDKETGAPAAAYRRKGWSYGIITLTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1P0</accession>
    <name>A0A2Z5R1P0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-antigen export system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88583">
        <property type="protein sequence ID" value="BAV88583"/>
        <property type="gene ID" value="RA11412_2284"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2284"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="156" mass="17446" checksum="BA67855200BE3405" modified="2018-10-10" version="1">MRYRGSVLGILWSYIKPGIQFGVFYIAMGLFLGLERGMHNYAIYLFAGMIVINFFSEGFGNGARAMVVNSALIRKIYLPRELFSLSTVWVALIHFLPQIVVMLIACIFSGWKPGVLNIASVVAGMLIVMLLSYGLGLIFGVANVFFRDSETWWICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Q2</accession>
    <name>A0A2Z5R1Q2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_10275</name>
        <name evidence="2" type="ORF">RA11412_2293</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88592">
        <property type="protein sequence ID" value="BAV88592"/>
        <property type="gene ID" value="RA11412_2293"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2293"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="791" mass="85349" checksum="27E26CD2ABDEE892" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1V1</accession>
    <name>A0A2Z5R1V1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_10465</name>
        <name evidence="2" type="ORF">RA11412_2251</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88550">
        <property type="protein sequence ID" value="BAV88550"/>
        <property type="gene ID" value="RA11412_2251"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2251"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="7"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="219" mass="23685" checksum="79925CC7A5D183CD" modified="2018-10-10" version="1">MKLTKYTHSSVRLENEGHALVFDPGNFAPEGEHARLLDGADYLVITHAHPDHFDTARLLPLLSEHPELRIWAPQAVTETILETVPDAKVNAVTADSEFTVPGFQVQTFGGQHALIHPLIPVIANIGYLVNGTVYHPGDSLVVPHGVKAPNVLVPVHAPWGKVQEVIDFVIAVGARRAYPIHNGMINENGTGIIEGLITTLGGKYGTEFTHLNPGDTVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Y4</accession>
    <name>A0A2Z5R1Y4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88580">
        <property type="protein sequence ID" value="BAV88580"/>
        <property type="gene ID" value="RA11412_2281"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2281"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="39" mass="4312" checksum="ACC7C220E09813AB" modified="2018-10-10" version="1">MVSHDLDLVSKICERGVVLDQGNLRFDGTIDKAVKIIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R232</accession>
    <name>A0A2Z5R232_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86949">
        <property type="protein sequence ID" value="BAV86949"/>
        <property type="gene ID" value="RA11412_0650"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0650"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016432993" evidence="2">
        <location>
            <begin position="30"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="153" mass="16151" checksum="03E6305E514A4DB2" modified="2018-10-10" version="1">MPAAALGSVLLIAFGLVLLIKQVPRKAAASPLRLTGSDGTLLATLSPDVIAQALSERAEDVPGVQRCSVWVTGSPSNLWVQATVTVAKNSEVAWTVSELRNRLDQDVSSSLGKHARQIDVLLRLEQATKPQSAAHTVAGKHSLESGGSDNHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R239</accession>
    <name>A0A2Z5R239_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_05430</name>
        <name evidence="4" type="ORF">RA11412_0660</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86959">
        <property type="protein sequence ID" value="BAV86959"/>
        <property type="gene ID" value="RA11412_0660"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0660"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020834">
        <property type="entry name" value="LipOase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00081">
        <property type="entry name" value="LIPOXYGENASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="230" mass="26124" checksum="2C42AF61D2A5B170" modified="2018-10-10" version="1">MPKLTPQMFTFLNDPPVEDTLYDLYDATLKQGKRMFLHFLPKIHQLLGKGIDWRTEDEDFYADKYIPITPQQGEFLYMQALARGARNIVEFGTSYGISTLYLAAAAKRNGGRVITCEYVPHKAEAARKNFERAGLADYIELREGDALKTLQDLDFSPDFVLLDGWPDLVHPVFQLLEPHLADRAVIAVDDVEGFSPSMQDYLDYVRTPANGYVSTTLRPHKALEYTVKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2E4</accession>
    <name>A0A2Z5R2E4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Acylphosphatase</fullName>
            <ecNumber evidence="3 4">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_04950</name>
        <name evidence="7" type="ORF">RA11412_0770</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87069">
        <property type="protein sequence ID" value="BAV87069"/>
        <property type="gene ID" value="RA11412_0770"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0770"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="6">
        <location>
            <begin position="19"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="105" mass="11243" checksum="00CA42507FBFE3A0" modified="2018-10-10" version="1">MGFFSYFTDKTAPEPAEAQLTAYVSGRVQGVGFRWWCAGTAKPMGLSGYAENLDDGRVKVIAQGTRASCEHLLDALNSGDTAGHVDFVDATFSDPQGTFKGFGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2F9</accession>
    <name>A0A2Z5R2F9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamyl-tRNA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88661">
        <property type="protein sequence ID" value="BAV88661"/>
        <property type="gene ID" value="RA11412_2362"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2362"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_dimer" evidence="1">
        <location>
            <begin position="24"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="125" mass="13880" checksum="8F0F75354035861F" modified="2018-10-10" version="1">MELITLESVRMAAPEETEEAVETAQRIVESEMQAFAARQKTRNIDAAIVALRGHTMSVLDTELEKVRNQFGCGAAAEQLELAMRRMVKSLLHTPTIRAKQMAAQGRTDEYVAGLEALYGIEVEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2P1</accession>
    <name>A0A2Z5R2P1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chaperonin GroEL</fullName>
            <ecNumber evidence="3">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-60</fullName>
            <shortName evidence="3">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">groL</name>
        <name evidence="3" type="synonym">groEL</name>
        <name evidence="8" type="ORF">I6I94_09365</name>
        <name evidence="7" type="ORF">RA11412_2505</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88804">
        <property type="protein sequence ID" value="BAV88804"/>
        <property type="gene ID" value="RA11412_2505"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2505"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="529" mass="56262" checksum="B1E3D234F099B318" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2R5</accession>
    <name>A0A2Z5R2R5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ThiJ/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_09655</name>
        <name evidence="1" type="ORF">RA11412_2442</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88741">
        <property type="protein sequence ID" value="BAV88741"/>
        <property type="gene ID" value="RA11412_2442"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2442"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="135" mass="14741" checksum="17FDF2C0154F9196" modified="2018-10-10" version="1">MFDFTHNFELHNIIASVYERGAIVASVGHGYCGILNVRLSDGSYLVNGKILTGPSWREEKLALVSQKVPYNAEELAKERGADYIRWRRPYRGSAAATNGLVTGHNNSSSGNLVASSVCDELDRLDSLKAKGSEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2S9</accession>
    <name>A0A2Z5R2S9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_09535</name>
        <name evidence="3" type="ORF">RA11412_2467</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88766">
        <property type="protein sequence ID" value="BAV88766"/>
        <property type="gene ID" value="RA11412_2467"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2467"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="2">
        <location>
            <begin position="120"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="349" mass="38291" checksum="361F1534A2F50624" modified="2018-10-10" version="1">MNETPEAATPAKPVPPSTQQESSIELAAPAAGLIYSAQAAPAPVLSRASLRIGYEPGVMPGKWFTRWHERYGRTAPLAEIPLREGAGLEALTTALSTPNSTSGEARFEPLAHMAIMRAAAQETPDKDRYHSIRLYEEVPVVVLPKDHVLTVLDEVPLGEMAEEFLLHEPEEFPAWGEASQQWRQQNPRFLPQIPTHADAIELVAAGVGLYITPMSVARLHHRKDLTYRPVPDAEPYPVHLVWPRTPAAPTPDTVQGEKDDEFEVLIQDFIGIVRGRTASSNRGSETAQARRTRIAGERAKTTAKSRAANARREARHQKTAASRTGGTSRRKAAAGSKPGRNGRRTGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2T3</accession>
    <name>A0A2Z5R2T3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89075">
        <property type="protein sequence ID" value="BAV89075"/>
        <property type="gene ID" value="RA11412_2776"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2776"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="231" mass="23802" checksum="294DAE3182D615CC" modified="2018-10-10" version="1">MGRAWAISGTAVLLGAAGHTLAGASAPHLMILILCTALGALMSLVLLLVMSRMRNRIPQALTAGTALGAVAVQALLHTLFNLSHAPSLAGEHIAAAHASTAAHGAHTHTLGNHVLPGNTPYDYAPSGGGVGGTHTLTHAAAEHAHIPMFGVHLVAAIASLGVLYSAERTLARLIRLLAMKVRALGVALFTPPAVLPLLGRRILLYIPNTPATGRVATLKYCRIERGPPAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2T6</accession>
    <name>A0A2Z5R2T6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rpsQ</name>
        <name evidence="7" type="ORF">I6I94_09140</name>
        <name evidence="8" type="ORF">NCTC10207_01773</name>
        <name evidence="6" type="ORF">RA11412_2561</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037234069.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88860">
        <property type="protein sequence ID" value="BAV88860"/>
        <property type="gene ID" value="RA11412_2561"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2561"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI23859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="90" mass="10389" checksum="B57FC1B35820DEB5" modified="2018-10-10" version="1">MSEVKNEERGYRKTRRGYVVSDKMDKTVVVEVEDRVKHALYGKVMRRSSKIKAHDEQNSCGVGDLVLLAETRPLSATKRWRVVEILEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2V2</accession>
    <name>A0A2Z5R2V2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08315</name>
        <name evidence="2" type="ORF">RA11412_2759</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89058">
        <property type="protein sequence ID" value="BAV89058"/>
        <property type="gene ID" value="RA11412_2759"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2759"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="62"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="218" mass="23853" checksum="DAB3A94903FAE55A" modified="2018-10-10" version="1">MAEIQFNAPGEREKSLWLIKKENDPGHSQWYIERFKQMEAEGNDLGGESRVLDAMASRGAKILDAGCGPGRVGKQLHALGHRVTGVDIDPELIDEATRVCPEASWVTADLADLPQALGFNGEADQDGFELLVCSGNVMGFLARSTRYPVVENFYRVLAPGGRAVVGYGSGPGRDYSFEQFLADARQAGFTVDATYSTWDLRPFTEDSEYLVAVLSRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2X0</accession>
    <name>A0A2Z5R2X0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89043">
        <property type="protein sequence ID" value="BAV89043"/>
        <property type="gene ID" value="RA11412_2744"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2744"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="341" mass="38101" checksum="DBE85C198AF7BB55" modified="2018-10-10" version="1">MQQERLLPHQVPLTTGRTGHRHSTVSEHVRQGVCRLKRLVPFSLTLRQPLTTKQLIHQRLSLLHLRIHQTPHTAAFNNHIGDAAQPLTGEHQPRGLLTDRHKRLRQRHRLNTRGGRLITAVNDHHTLKTVTVIIRSNHVQPQLGGVLLLLRLVGGNNDRQRLRVRHHGTSGALNNGGLIRQVRQTLPQVAGGSGFTAAGCPHQSNGTLRGGVTNGGSMQQHLRTTHQLLNHSDREHGRHGLQRLSLTGDVHHLHGLETVHQLRDLIKQVSAAIMRHEHMRHGAGRLNSRLNALIQHRVEGSPNLLHLAHELLVSAGTKHHLQLGASGPHNHCREQQYSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Z7</accession>
    <name>A0A2Z5R2Z7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89073">
        <property type="protein sequence ID" value="BAV89073"/>
        <property type="gene ID" value="RA11412_2774"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2774"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="54" mass="5845" checksum="40B0B57F6BAEA9AB" modified="2018-10-10" version="1">MPDEALAPCPPAALAPAEADELAEEDADAEPDEPVLVEPPRRRRAAAPQLRRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R374</accession>
    <name>A0A2Z5R374_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_08755</name>
        <name evidence="4" type="ORF">RA11412_2657</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023133167.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88956">
        <property type="protein sequence ID" value="BAV88956"/>
        <property type="gene ID" value="RA11412_2657"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2657"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="86" mass="9820" checksum="5E248116547012C8" modified="2018-10-10" version="1">MTVMTNQEFKQNVSQAQKTAQTEPVIITNRGEPAYVLMTYTEYEKTLQSKSVRSGLDALMPLDAADIELELQPRSRAQRRPVDFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3D5</accession>
    <name>A0A2Z5R3D5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose 1,4-beta-cellobiosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89081">
        <property type="protein sequence ID" value="BAV89081"/>
        <property type="gene ID" value="RA11412_2782"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2782"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="157" mass="15582" checksum="63161618EE0A4D4A" modified="2018-10-10" version="1">MKISGSDGKGNSADVNVGKGGDVSVSASASSGETASDEASEDSTASADDKADSAASSESAEGKLTMNDSGAWVLVKPDGTQITVNAGGAWALQKSDGTHITVNASGAWSMTDADGNTTTVNENGAFHSDNGTPTVPQVPAKPNDKAATPTTPVQPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3P3</accession>
    <name>A0A2Z5R3P3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6493 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87739">
        <property type="protein sequence ID" value="BAV87739"/>
        <property type="gene ID" value="RA11412_1440"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1440"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="50"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="739" mass="81539" checksum="3EAFF995A2F33F14" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3Q5</accession>
    <name>A0A2Z5R3Q5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside 5-triphosphatase RdgB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87809">
        <property type="protein sequence ID" value="BAV87809"/>
        <property type="gene ID" value="RA11412_1510"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1510"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="198" mass="20669" checksum="4C3AE14E0325EEDE" modified="2018-10-10" version="1">MAKIVLASHNQGKLRELREILRGRIDGLNVETDVVDASAVHAPDVPETGVSFAENSLIKARAIAEATGLIAVADDSGLSVDVLGGAPGIFSARWSGVHGDDTANLNLLLHQLSDIADEHRAAKFCCAASLAVPEADGGYEAVEYGELPGCSCTPRRVTAGSGTTRSCSPQNLTAITPSTAATMPGNRAHKYRPRLKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3S3</accession>
    <name>A0A2Z5R3S3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Riboflavin biosynthesis protein RibD</fullName>
            <ecNumber evidence="7">1.1.1.193</ecNumber>
            <ecNumber evidence="6">3.5.4.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RA11412_1630</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.193" evidence="7"/>
    <dbReference type="EC" id="3.5.4.26" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87929">
        <property type="protein sequence ID" value="BAV87929"/>
        <property type="gene ID" value="RA11412_1630"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1630"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="13">
        <location>
            <begin position="38"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV87929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="430" mass="46339" checksum="286F544B6E2ABAC6" modified="2018-10-10" version="1">MVSVMHTPVNDLDYSAAEYGHVDGIPSPYTFSIPDGPLTDEQAMRLALDAARCGIRGANPLVGAVITGTDGRVLYVGWHRGAGTPHAEADALAQARAAGTDPRGASMYVSLEPCNHTGRTGPCSHAIVAAGVRRVRYAYPDTTSAAGGAAHLRSNGVDAQLMEGFSADSYLLNERWFIAAAERRPFITAKSASTLDGFIAAADGTSKWITGPAARIDGHLVRHRADAVMIGTRTALTDDPSLDARRSDGSRFTKQPLRVVMGRREIPESYRIRGLAAEGPYDPDPDRFLQVFTHDPFELLSTLYDRGVRHLMIEGGPGMVGLFAGEDLVDEMIWYRAPLLLGHGKSAVYRLSTGTLANAPRLHLDDLGMFPAVRVLGADTATHLVPVPRGDYQNPGARRVLERCTECYAPSPARTGEGCIIRGRIRRVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R415</accession>
    <name>A0A2Z5R415_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Holliday junction DNA helicase RuvB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88209">
        <property type="protein sequence ID" value="BAV88209"/>
        <property type="gene ID" value="RA11412_1910"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1910"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuvB_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4512" checksum="45677E1FA8DF618D" modified="2018-10-10" version="1">METVAEPYLVREGLIGRTPRGRVALPAAWEHLGLEAPDINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R458</accession>
    <name>A0A2Z5R458_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_2010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88309">
        <property type="protein sequence ID" value="BAV88309"/>
        <property type="gene ID" value="RA11412_2010"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2010"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_C" evidence="3">
        <location>
            <begin position="58"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="222" mass="23671" checksum="4E6F89CAF2E1C2A1" modified="2018-10-10" version="1">MTLRGLAGEYPDIELPLHGEHQGQNASLALAAVEAFFGGDRALARDVVLAGFAQVRSPGRLEMIRSEPLVVLDAAHNPHGVRAASTAFKEAFELSHVHAVVGILGEKDALGIFEVLREEYVDSTDATFRLYLSASDSSRAIAPEELQEIALDAGFDENIITVCNHLDEALATGMENALFEQESAGVLVTGSVTVIGEARTLLAQPEESPTASRPALKDLIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R486</accession>
    <name>A0A2Z5R486_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Formamidopyrimidine-DNA glycosylase</fullName>
            <shortName evidence="15">Fapy-DNA glycosylase</shortName>
            <ecNumber evidence="15">3.2.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA-(apurinic or apyrimidinic site) lyase MutM</fullName>
            <shortName evidence="15">AP lyase MutM</shortName>
            <ecNumber evidence="15">4.2.99.18</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 20" type="primary">mutM</name>
        <name evidence="15" type="synonym">fpg</name>
        <name evidence="20" type="ORF">I6I94_11105</name>
        <name evidence="19" type="ORF">RA11412_2080</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23" evidence="15"/>
    <dbReference type="EC" id="4.2.99.18" evidence="15"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88379">
        <property type="protein sequence ID" value="BAV88379"/>
        <property type="gene ID" value="RA11412_2080"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2080"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00103">
        <property type="entry name" value="Fapy_DNA_glycosyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15 20" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15 20" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="18">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="17">
        <location>
            <begin position="280"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="15">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for beta-elimination activity" evidence="15">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for delta-elimination activity" evidence="15">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="BAV88379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QQT89031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="327" mass="36178" checksum="6348B4B3FE201D4D" modified="2018-10-10" version="1">MPELPEVETVREGVQTHAAGRVIERVRILDARSTRRHVPGTADFAARLEGTRIHGVYRRGKYMWLTLAATGRGGCASGELLPYALVIHLGMSGQLLVKTPDFAPEKHLKIVLELEPADGESTGQTTELRFVDQRIFGGMFLSDVVSDIPVSASLSGAEEIPEEFLVPQAVQHIGRDPVDPYFDLSLIRAKMLRTASGIKRLLLDQSVVSGIGNIYADEALWRARIHYAKPSRTLSAAQTRELFAAVQQVLTEALRVGGTSFDALYVNVNGQSGYFDRSLNAYGRAGEPCRRCLDEGRTSIIVREPFMNRSSYRCPHCQRTPRGLDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4W8</accession>
    <name>A0A2Z5R4W8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Folate-binding protein YgfZ</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Folate-dependent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_08850</name>
        <name evidence="4" type="ORF">RA11412_2630</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88929">
        <property type="protein sequence ID" value="BAV88929"/>
        <property type="gene ID" value="RA11412_2630"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2630"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="PTHR22602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCV_T" evidence="3">
        <location>
            <begin position="53"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="402" mass="43178" checksum="1F3E8D2540F7AB41" modified="2018-10-10" version="1">MSTAENIAADAPEYTPIPSPLMQVHGAFAADGPDAGVAAHYGNPLAEQRALVRDRGATTGDPVVVDRSSLGVVRVSGPDRASWLTSLASQILTDMNPGDSREFLLLSPQGRIEYAPAAVEDGQALWLVVEGAQAEPLTDYLNRMKFMLRVDIENMSGDYAVVETARNPRGKQGAAHPAFADALIWRDPWTALVEGGYHYSATPDSHPGTDYERYLSIIPREKLTTLTEGAQLAGVWAAEALRIEAWRPRAGTEVDNKTIPQELDYTRTAVHFEKGCYKGQETVARVHNLGHPPRRLVFLDLDGSEHTLPAAGSELFVEGKPRAVGRITSVALHHEAGPIALAVIKRAVDPAAPLRAVDTGEAATDESSAPATEYAAAQTLIVSPEAGEIARKSVAGQDFLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVB9</accession>
    <name>A0A2Z5QVB9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08000</name>
        <name evidence="2" type="ORF">RA11412_0039</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86338">
        <property type="protein sequence ID" value="BAV86338"/>
        <property type="gene ID" value="RA11412_0039"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0039"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="385" mass="43308" checksum="93866D88E1267736" modified="2018-10-10" version="1">MAGYTLDVPEELYEALQKMAPYATYTYTDEDGDWDLLSPAGHSALTKDRVLDADLLNLYFEVLPQIATLFAKQHPRALNTFSAVPTPSAIKMPKAQLTPLIQVEKERAEEEAHWASLEEEFYAGVPEEERNYGVTPGLKHYMMRENLGYALLLDIINDPDAEYSTSHNNGYEVPVYTSKKLGYRVVLTHNSSAVMSLRKIDDGMVGKYSLAEAAEQHMKDLGLREEELILVLESIDSEVSAVPGHSARTGYRLNGYEVIVDSVRKTILSVAEASASPGTRPTPHNQPRLSGQKAQRGVKIPNDMPSYIKLLETHGFTVEHGKTHYKVTHDAFPGKSVSMPVTPSDSQRWYKNSVSDMRREFGVNLKRDRPEYTRRGEPTPRHERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVC9</accession>
    <name>A0A2Z5QVC9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ACT domain protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">ACT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08045</name>
        <name evidence="4" type="ORF">NCTC10207_02007</name>
        <name evidence="2" type="ORF">RA11412_0027</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887639.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86326">
        <property type="protein sequence ID" value="BAV86326"/>
        <property type="gene ID" value="RA11412_0027"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0027"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI24289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="89" mass="10094" checksum="F7FD3774531639E5" modified="2018-10-10" version="1">MKIILTVTGIDHEGIIAAVTNTLAERHVNVLDVSQTIMGEYFTMIMHCSFDENEQNLIDLQEAMIPVEHAQKVQIRIQAEAIFKTMHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVG9</accession>
    <name>A0A2Z5QVG9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="12">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cysS</name>
        <name evidence="14" type="ORF">RA11412_0005</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="12"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86304">
        <property type="protein sequence ID" value="BAV86304"/>
        <property type="gene ID" value="RA11412_0005"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0005"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="13">
        <location>
            <begin position="366"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="12">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="12">
        <location>
            <begin position="290"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV86304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="486" mass="53945" checksum="D297E46D32D21AE2" modified="2018-10-10" version="1">MGAVPRKLGTVTMRFYDSATSSIRDFEPVVPGEARIYYCGATVQGEPHVGHIRSALVFDQLARWMRYRGFKVTTVRNVTDIDDKILAKSVESAQPTYAGEHPNEQWWALAYRYEKVFARAYATLGIDPPTYEPRATGHIPEMFELIQRLIDRGHAYPALDDSGDVYFDVRSWEHYGALTRQSVDDMQDSADADPRGKRDPRDFALWKGYKEGEPVTAAWDSPWGRGRPGWHLECSAMAGKYLGKRFDIHGGGLDLRFPHHENELAQSTAAGDDFANFWMHNGMVTYEGEKMSKSIGNTISPVQMLQQARPLVVRYYLGSAHYRSVLDYRPTSLEEARVAIERVEAFLAATSELMAPNPQERRVPQDFADALDDDMNIPRALAVLHEQTRAGNAALAAGTDASEYANAVWAMANVLGLTSLMNLDGSGASGTEHQALDALIHTILEQRASARAEKDWATADRMRDVLAAAGITVKDGAQGSTWSLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVH2</accession>
    <name>A0A2Z5QVH2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86382">
        <property type="protein sequence ID" value="BAV86382"/>
        <property type="gene ID" value="RA11412_0083"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0083"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="40" mass="4367" checksum="229A82FA82DF1CF8" modified="2018-10-10" version="1">MVFQPINMKNEQNITGSNTLTEDTPAPADNTPAAPKPQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVH7</accession>
    <name>A0A2Z5QVH7_9MICC</name>
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        <submittedName>
            <fullName evidence="9">Excalibur calcium-binding domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="8" type="ORF">RA11412_0099</name>
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    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
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    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86398">
        <property type="protein sequence ID" value="BAV86398"/>
        <property type="gene ID" value="RA11412_0099"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0099"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008613">
        <property type="entry name" value="Excalibur_Ca-bd_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05901">
        <property type="entry name" value="Excalibur"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00894">
        <property type="entry name" value="Excalibur"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340086" evidence="6">
        <location>
            <begin position="32"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="401"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <begin position="154"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="436" mass="42727" checksum="363B91C6F0250B02" modified="2018-10-10" version="1">MTTHHKFATIGAVATLSLSLVGATAVPAAFAAPATNTAAVAPAANASHTYDDGATITFPSSWTVGQGLSFTGTGFKAKDGSPSVLALKIDGGGVSGQPYLRVEADANGNVAGTIPWQEGFKPGQTVTLTVLTGSLNKQDPRRGGDAATVTIQAAAAPSASPTDTAAASAAPAPTEATPSSSASAAQSATEAPAASSASAAVTGKPQPPVQPSAAPSQSEQAANNSAQDSSSAEHNVPNASANAEHLAAAAQGSAVAGEIPKNCTEASARGLSNIDANSPHYSEHLDRDKDGVGCETKATGTSGSGTTSTTGGKQAAAADTSTDDKPDNCTEARARGLNNIKAGSEHYSGHLDRDKDGVACESRVSGSYSGGSASRVSSTGTVASTGSTGSYSAASTTRGRLASTGASGALTIAGVGLFTLVAGTTVVLVARRRKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVM3</accession>
    <name>A0A2Z5QVM3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86445">
        <property type="protein sequence ID" value="BAV86445"/>
        <property type="gene ID" value="RA11412_0146"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0146"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
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        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="49"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="140" mass="15454" checksum="D9661A930EABDFCD" modified="2018-10-10" version="1">MMSKFKTEVTEGIFPLGEVNPVSTAPDMPSSYNYPLVFDPEVSAKVANVSFEPGARTKWHKHVGGYQILLVTAGEGWYQQEGEEPRKLHAGDVAVARNGVKHWHGAAADSWLSHIVVNAGEAVWGDPVTDEEYPDSEKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVP8</accession>
    <name>A0A2Z5QVP8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FtsX-like permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_07505</name>
        <name evidence="3" type="ORF">RA11412_0176</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86475">
        <property type="protein sequence ID" value="BAV86475"/>
        <property type="gene ID" value="RA11412_0176"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0176"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033776633" evidence="2">
        <location>
            <begin position="26"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="477" mass="50975" checksum="C2B577E70316E910" modified="2018-10-10" version="1">MQTFTMLARRTLPTTQAVMPVLAFAASAALTLLVAGGIQAFHLWLGDPSLPGRGAQSHPSNYLQSAYILLAWASGFLLLTPLFTLGASAARLSARRRDDRLATLRLLGASTGRITLYTVAEALIYATVGFFIGFVLYLVLTIPFGMLHFLDTPLGAHNMILPAHLVFACYVGCLVIAALSSLFGLSKVTISPLGVRTRANAPKAGIVFLIAGLAVLVLGFIGAQLVLKILRASVGDGTFGTAMSVMFVLLILTLIVVFPLVLGMIAVDLLGGFTVWLYATIRVRIARTPAALLAWRAVLESPRAAWRQVSGVAMTTFIAALIGPVLGQLFRESTSQARRNVQDDTLLNDMWQGLFLLMFLSYLLVALSALLNQSAAIYERGSLYSSLRMMGTEAAVLKRSRRIVVFGPLLLVSTLSGLLALVLFGLIARSGVEPRFLLQSLGMIVVAIVLGMGLVFASLAATGPVMERVSRKPVSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVQ0</accession>
    <name>A0A2Z5QVQ0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86456">
        <property type="protein sequence ID" value="BAV86456"/>
        <property type="gene ID" value="RA11412_0157"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0157"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="38" mass="3984" checksum="E8A1BF170CD89B1A" modified="2018-10-10" version="1">MPSRTLSTLFMSITPSSAQLERSPCSAGAIPKSSLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVU3</accession>
    <name>A0A2Z5QVU3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86506">
        <property type="protein sequence ID" value="BAV86506"/>
        <property type="gene ID" value="RA11412_0207"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0207"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="136"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="344" mass="36171" checksum="3D76E8EAD5656F9F" modified="2018-10-10" version="1">MAYAIGAIISMQFGSALAKTMMGDLGAWGVVTLRLITSSLLLYVFFRPQVRQWTRPQWIAVTVLGVALFGANAFFYVAIQQVPLAIAVAIEFMGPLVLATVLSRRKLDLVWVALSFTGMAVLTADSQANPEDFALAGVFFAVLTAISRAAYILATEKVGASIPGMGGMVMGNIVSTLLVLPFPFFITGNHLEKAITDPALLGLGFVMGLLASALPALGEVSALRMLPSNVYSVVLSLEPAFAAIVGIFMLAENTGLIRWAAIALLISASIGITLSHARAERAALAAGKRESIEPYLPGAVDNIGAGIAQMTGAIELPTPEQVAADKARRQDTAGKTHPRTGEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVV6</accession>
    <name>A0A2Z5QVV6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_07275</name>
        <name evidence="3" type="ORF">NCTC10207_02171</name>
        <name evidence="1" type="ORF">RA11412_0229</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86528">
        <property type="protein sequence ID" value="BAV86528"/>
        <property type="gene ID" value="RA11412_0229"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0229"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI24618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="219" mass="24644" checksum="77540C871DC92D8E" modified="2018-10-10" version="1">MVEKKTLCLADEVVNADLQFLMNAGTVLTTNVYNIDAIGRTIAEVITAGRAFNVARPSHVYDRVMSMHAHPALGSFTETLADMRQAARNALILRFPAPNERGLEVAVRIERVMGTKLAVTKVCCRPAGTRRWYEHWAKEVLQIDGYLIAGESRRTRGMFEVHRQNLLFALGMLDVAMLGLSASEADFHWLASPKSAVTKFKRQRRDLLRRIRQDYAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVX2</accession>
    <name>A0A2Z5QVX2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_07600</name>
        <name evidence="1" type="ORF">RA11412_0145</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86444">
        <property type="protein sequence ID" value="BAV86444"/>
        <property type="gene ID" value="RA11412_0145"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0145"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="137" mass="14851" checksum="476C39F57C0ED137" modified="2018-10-10" version="1">MSQYETEVTEGVFPLGGVNDALAQYFSGTSYMNTLVNDPDVPVTVANVSFELGVRNNWHKHNGGFQIILATAGEGWYQEEGHPPAKLHAGDVALAKDGVKHWHGAPVDSWFSHLVITAGTAEWLEPVGDGEYPNSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVZ4</accession>
    <name>A0A2Z5QVZ4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="3">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">pdxS</name>
        <name evidence="7" type="ORF">I6I94_06930</name>
        <name evidence="6" type="ORF">RA11412_0286</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004006448.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86585">
        <property type="protein sequence ID" value="BAV86585"/>
        <property type="gene ID" value="RA11412_0286"/>
    </dbReference>
    <dbReference type="GeneID" id="29743582"/>
    <dbReference type="KEGG" id="raj:RA11412_0286"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <source>
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    <sequence length="303" mass="32066" checksum="E92B98B53D26281F" modified="2018-10-10" version="1">MTEQTNSPVTGSPLVKRGLADMLKGGVIMDVVTPEQAKIAEDAGAVAVMALERVPADIRAQGGVARMSDPDMIEGIINAVSIPVMAKARIGHFVEAQILESLKVDYIDESEVLSPADYVNHIDKHQFTVPFVCGATNLGEALRRIAEGAAMIRSKGEAGTGDVSEATKHIRTIKRQIAELQGLYNTMPDELYVKAKELAAPYDLVLEVAKTGKLPVVMFTAGGVATPADAAMMMQLGADGVFVGSGIFKSGNPEARAKAIVKATAFYNDPEKLADASRGLGEAMVGINVADLPAPHRLAERGW</sequence>
</entry>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
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</entry>
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    <accession>A0A2Z5QW02</accession>
    <name>A0A2Z5QW02_9MICC</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 3" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86474">
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    </evidence>
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            <dbReference type="EMBL" id="BAV86474.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="309" mass="32071" checksum="CC195902F588A7A9" modified="2018-10-10" version="1">MPIVLACGLVCLIIAATSSLFGLSKVTISPLGVRTRSDKPSLGKRTLILGGVLLVVGFIGAIASQVIMNLAADSMGANGFVLVLVIAIMFGLPILLTMLAVDLIGGFVVGLYARIRVRTARTPATLLAYRSILESPRTAWRQVSGVAMTTFIAAFMGPILGMVNSASGVDEGSAESYLIGDMLQGLVLVLFLSYLLVALSALLNQSAAIYERGSLYSSLRMMGTEAAVLKRSRRIVVFGPLLLVSCMSAAVALPLFVLMLGSALTGTGLLYTAALVFGSIAVGLGLVFAALAATGPVMEQISRKPVSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW94</accession>
    <name>A0A2Z5QW94_9MICC</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
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                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86650">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="199" mass="21459" checksum="D93810B0DCDB2F70" modified="2018-10-10" version="1">MVTTATAITGPPIPSWDFSSVKANAYNMATVGLNNKNASIHREARENLGTPAAIFMASEIGQNSTIIGRTSARIIISIHWIRTTRTIMPENIIDIAPALATNAAGSFSRASLTLSLSHCAILRIHPAILSLAVIIHAINAEPPVETIMTRARLCIIRRRSSPRAFHIALPPAMRIPITAQIHTIGPVATFIQSIVSFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWA5</accession>
    <name>A0A2Z5QWA5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0372</name>
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    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86671">
        <property type="protein sequence ID" value="BAV86671"/>
        <property type="gene ID" value="RA11412_0372"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0372"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022435">
        <property type="entry name" value="Surface-anchored_actinobac"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03769">
        <property type="entry name" value="P_ac_wall_RPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016329582" evidence="1">
        <location>
            <begin position="39"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="388" mass="41803" checksum="9FCAA2E9CDF13A56" modified="2018-10-10" version="1">MNTHLRTQRRAPGKPLARLSVAALIILTGLAPSITAHAGPDDGRIITTKGHVDAPKAYWENGTFVLKNESNPYKTGADLYDLDKTVNWVGKGWDGRNGASQYTLTLPNSPSLGFLGEPGQTLYMAPTLTWGNHDPIWAGLGASVKIPTEQFRDGVFATDILSVDGPGRMELFRYNPDDGPAQINRILSSTSTGWHSWLLSKGSHTHNTTTFTRPGRYEVTYRTVARGTDGRIIQSAPQKLVWQVGGNKPILGDGTPTAVPTEERYNAANVGNLDTAKYVLSVAPHTPDPDPAKRRDADDKLSDITFTAGDKNLKGKLTLYNNGYFLTDLDVTNGTATWSEMMGGESSHLQAVFTLKATAVHAGSRINSRMSPGGLRACTVTTATANGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWG4</accession>
    <name>A0A2Z5QWG4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86765">
        <property type="protein sequence ID" value="BAV86765"/>
        <property type="gene ID" value="RA11412_0466"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0466"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="290" mass="30182" checksum="0E579390F549313C" modified="2018-10-10" version="1">MTEQRSLSDVYDDEAALGTEIFGATVPTQPAAMEVIGAIKSWDGNPIQPEMGGGMYPGGDLYDDDEDDEDDGRRGTWVIVLAAVLLLLIVAGAVLISLTGIGSSKTAEPKPAKSTSASASASEGGESPSPTPSPETTSNAPAKIATVARLVPNNPTFMSETDANLPKLADNNPATVWMSYGFGSGKLAVPFALSAKLQTPTVVSKVTMQQNTGTGGAYTVYVNNQNSLNGATEVGKGTFNGKDAVVELDTSKQSADKGGYVIIQFTEAPKLSQPISIYPYGLRLAELKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWI6</accession>
    <name>A0A2Z5QWI6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2648 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Protein of uncharacterized function (DUF2648)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_06110</name>
        <name evidence="3" type="ORF">NCTC10207_00009</name>
        <name evidence="1" type="ORF">RA11412_0488</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI21947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86787">
        <property type="protein sequence ID" value="BAV86787"/>
        <property type="gene ID" value="RA11412_0488"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0488"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI21947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="37" mass="4181" checksum="297F9F7EE1AEB6D9" modified="2018-10-10" version="1">MKKLLILLLLSGAAFLGFKKFQGNQVRQAWQESTDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWQ0</accession>
    <name>A0A2Z5QWQ0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05980</name>
        <name evidence="2" type="ORF">RA11412_0512</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86811">
        <property type="protein sequence ID" value="BAV86811"/>
        <property type="gene ID" value="RA11412_0512"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0512"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="142" mass="16259" checksum="6F5730B18BDEDC21" modified="2018-10-10" version="1">MSSTNKGRNPESFGGAFRQAARESLVKNQRERSSDIVSIAPIQLALAALAIGIYALWNSWLCLIPLGVVLVLMWVRYTMQRQISRDFEQLDAACTAWRKTRDKQYLEFMAENAGRILRENKALTKDARKRVQEYAEYASSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWT6</accession>
    <name>A0A2Z5QWT6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06545</name>
        <name evidence="2" type="ORF">RA11412_0385</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86684">
        <property type="protein sequence ID" value="BAV86684"/>
        <property type="gene ID" value="RA11412_0385"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0385"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340093" evidence="1">
        <location>
            <begin position="42"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="171" mass="18485" checksum="04CF198E30084299" modified="2018-10-10" version="1">MTNEHSGVSRRKLLRTTAIGVPAAGMLAFGSTLVTAPSANAATVKVIDGLWGKETSAGVQRLMNLLYPQAGLVVDGVISSQPSRLKQPGLATFGWEWVPDNQAAGSPTMYWMHKWLGDIRHGLDSSTAKYHITHSFIFALQKHYGIPADGVLDDSSKTIKGLQNEINQWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWV9</accession>
    <name>A0A2Z5QWV9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I6I94_06455</name>
        <name evidence="10" type="ORF">RA11412_0405</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86704">
        <property type="protein sequence ID" value="BAV86704"/>
        <property type="gene ID" value="RA11412_0405"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0405"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="26"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="337"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="371"/>
            <end position="378"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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            <dbReference type="EMBL" id="BAV86704.1"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="QQT88190.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="579" mass="62209" checksum="13EF30A529E9872D" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWW2</accession>
    <name>A0A2Z5QWW2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86918">
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        <property type="gene ID" value="RA11412_0619"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0619"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="70" mass="8153" checksum="D7AC415E22B8FDBF" modified="2018-10-10" version="1">MRDDTHIRDTGHRRFFSCRIKPIGVPSTRSNHGVCGLGRYLKVEGTHVQCWVLIGLKNHVSYCRVRCRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWY6</accession>
    <name>A0A2Z5QWY6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
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    <reference evidence="1 2" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86836">
        <property type="protein sequence ID" value="BAV86836"/>
        <property type="gene ID" value="RA11412_0537"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0537"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="73" mass="7473" checksum="06D2B28DE9AF5343" modified="2018-10-10" version="1">MADEVASAGLNLPGSGQAGISGSVYLLYGLYELEATGRSGARGIVSSFLAENTAHELKTSVSAVPAEMDARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX13</accession>
    <name>A0A2Z5QX13_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">RA11412_0663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86962">
        <property type="protein sequence ID" value="BAV86962"/>
        <property type="gene ID" value="RA11412_0663"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0663"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="52" mass="5777" checksum="A4A64B1C7107284D" modified="2018-10-10" version="1">MHGTAYDALAQRRTFRRAAVTRVRGVNDRGPKLTGQRPRSNRADGLPDEGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX17</accession>
    <name>A0A2Z5QX17_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86985">
        <property type="protein sequence ID" value="BAV86985"/>
        <property type="gene ID" value="RA11412_0686"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0686"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="147" mass="16316" checksum="FE28E1912163C4B9" modified="2018-10-10" version="1">MNAQNNTGDNTSQNEQEHRNHPCGEPSPTRELYKKLGHIGRLTHLWAAQQRERTGLGRIDTTRGQGRILAALKLKDGIATRELAYVLGIRVPSLNEALSKLENAGYIVREPDPRDRRVQLITLTDSGRALTGQLGEGEPEGDNILRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX53</accession>
    <name>A0A2Z5QX53_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA integrity scanning protein DisA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">disA</name>
        <name evidence="13" type="ORF">I6I94_05130</name>
        <name evidence="14" type="ORF">NCTC10207_00209</name>
        <name evidence="12" type="ORF">RA11412_0726</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DisA family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888339.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87025">
        <property type="protein sequence ID" value="BAV87025"/>
        <property type="gene ID" value="RA11412_0726"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0726"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01438">
        <property type="entry name" value="DisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038331">
        <property type="entry name" value="DisA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018906">
        <property type="entry name" value="DNA_integrity_scan_DisA_link"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023763">
        <property type="entry name" value="DNA_integrity_scanning_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10635">
        <property type="entry name" value="DisA-linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="9"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="107"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV87025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT89974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VEI22143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="357" mass="39581" checksum="B8196B4023E85574" modified="2018-10-10" version="1">MEHVQTDYSELLLKTIARIAPGTELREGLERILRGRTGALIVLGSDRTVAALSSGGFDIDTEFSATRLRELAKMDGAIICDRDATRLLKAAVQLMPDPFIETNESGTRHRTAERIAIQTGFPVISVSASMSVISVYVDGTRYTVQDTQYLMSRANQAIQTLESYKKRLRKVLGTLSTLEIESHVTLGDVAATLQRMEMVRRIISEVSHYVLELGVHGRLVALQLEELRSPDMPGSEIILFDYLPNPNPRNIGDAVEALENLDDMNIVDLKVIAQVVGFEGYDLDTPLQPRGYRLLDGIQSIPHIISSRLVERFGTLQALMAATLEDLRAVEGVGGNRARTLRESLSRMAESTLEKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXB3</accession>
    <name>A0A2Z5QXB3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Alkanesulfonates ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_04880</name>
        <name evidence="5" type="ORF">RA11412_0788</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87087">
        <property type="protein sequence ID" value="BAV87087"/>
        <property type="gene ID" value="RA11412_0788"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0788"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="273" mass="29371" checksum="E7FC884F9CFA1C00" modified="2018-10-10" version="1">MTQNHHTQLPANAQTITFDAVSQSFPQSGKNTHEVLREVSFTAAAGEIISVIGASGCGKSTLLRAAAGLNRITGGQVRIDNTPVSGLDQRVAIGFQEPRLLPWRTVADNVALGLPQGTPKTRAQERIRELLRLVGLADYATHRPKEISGGMAQRVSLARALAREPGVLLLDEPFGALDALTRIKMQDLLLDIHRQDPTTVLLVTHDVEEALYLSDRVIVLGKPAPDASATITRVVTISDAHPRDRASKELTALRAELLTELGVEKADTALVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXI6</accession>
    <name>A0A2Z5QXI6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87046">
        <property type="protein sequence ID" value="BAV87046"/>
        <property type="gene ID" value="RA11412_0747"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0747"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="188" mass="20485" checksum="49AE0941632DE50A" modified="2018-10-10" version="1">MRLGIKLIYAHAVLIVVHGVVSFYRDTIPTSTTVYAQHGAAAMDVTIGKIAVLYAVITLVLVATNILVGVFYSRGYTWARITAAVLAILGAMNNLLLGLLTLIGVFELFAALSRASDSADPGYIEAYRYATIFVVASAVLYLVGLLLCIIIAVYMFKPQAAAFTTNWGMWRAYQKNPSMYVQIPPAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXL7</accession>
    <name>A0A2Z5QXL7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Minor extracellular serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87182">
        <property type="protein sequence ID" value="BAV87182"/>
        <property type="gene ID" value="RA11412_0883"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0883"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="238" mass="24793" checksum="01D3C392A454575F" modified="2018-10-10" version="1">MIEVAPGTGAKTVTKEVTVENAGGQQRTFRVGFDARTTTAGVQVKTPESVSVAAGAKATFRVSVTVDPEKLAKTLDAGTARDQGGRYRQYLSSVSGNVTLTDSSSTVVVPLHAAPKPVSELMVPSASLTFGTSQTARIKPEGTPVRRNGYVSQLGAFELGYEESGPAPSSSSARAMAVQYVGASSNLPALGASGSSQGRGVISFGVATRGNWDALTRPTVLRLRLTRTATATRITRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXM8</accession>
    <name>A0A2Z5QXM8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flp pilus-assembly TadE/G-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_04365</name>
        <name evidence="3" type="ORF">RA11412_0916</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87215">
        <property type="protein sequence ID" value="BAV87215"/>
        <property type="gene ID" value="RA11412_0916"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0916"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021202">
        <property type="entry name" value="Rv3654c-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03816">
        <property type="entry name" value="tadE_like_DECH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="143" mass="14321" checksum="55607C6B16A5AB8C" modified="2018-10-10" version="1">MKNKHSVLRANAPTPRTASAGRATEEGSGTVLALTIIAGVLILTVLTLGAAGAYAAHRRAATAADLSALAAADTLRGLSEGEPCANAARIAQENGANLAACTEPSRPDTMDVRVSVPITGPFAFLGDAKGQARAGAPDDTGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXV2</accession>
    <name>A0A2Z5QXV2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87191">
        <property type="protein sequence ID" value="BAV87191"/>
        <property type="gene ID" value="RA11412_0892"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0892"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="67"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="351" mass="38150" checksum="CA5CB5DFBCF0EBCD" modified="2018-10-10" version="1">MRDSAPSRRMLRAAAPAARTGSVLKKTVAAGAVLGVAAAAYGHFIELNNFVVRHERLPVLPAGTADLRILHISDMHMIPGQARKREFMHSLAGLRPDLVINTGDNLSHINGLPPLLDALDPLMDFPGVFVPGSNCYFAPVLKNPARYLWQARTPQEIEEGSRVPLPIGKMHDAFESRGWTGLINRYDSISIGGLRLEFSGVDDPHLRYDQHPGFAPEAFDTGSTPRVRIGVAHAPYMRTLERFVADGAQAIFAGHTHGGQVCLPGGRALVSNCDLPPSRAKGVSYQQDVPVQVTAGLGTSRFAPVRLFCPQRRCWSPSQPRANKHPAVGRDLGRAPHSRASPRQTARGRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXV4</accession>
    <name>A0A2Z5QXV4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_04165</name>
        <name evidence="1" type="ORF">RA11412_0973</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888147.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87272">
        <property type="protein sequence ID" value="BAV87272"/>
        <property type="gene ID" value="RA11412_0973"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0973"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="228" mass="25512" checksum="DECA6EB103D0C7BB" modified="2018-10-10" version="1">MTTSAKVTVHLMRHGEVHNPDRIVYGRLPNYHLSEKGQQMVRMSAQEFARRRGEGANIVHLVCSPLTRTRESAEPITELLGLQAHPDARVVEADNYFEGLHVNRQELLNNPRHWTKLYNPLRPSWGEPYIVQVRRMAQAIKDAARTAYQQGGDGAEAIIVSHQLPIWVTRLALEGKLLQHDPRARECNLASITSLTFDNLLSGNPPQVSGYTEPASPLYSGVIQLPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXX3</accession>
    <name>A0A2Z5QXX3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_04005</name>
        <name evidence="3" type="ORF">RA11412_1009</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888165.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87308">
        <property type="protein sequence ID" value="BAV87308"/>
        <property type="gene ID" value="RA11412_1009"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1009"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="155" mass="17361" checksum="0CD39EE7C6E8ACB6" modified="2018-10-10" version="1">MQNPPQPTKQPTAPQHPNRLGAPQPPDPEERRRTVMRIARAQGLAVVSTFLGLVCLTYPMPFFLLAPVVLLAGLALNIVVIVRTALTRSPIVFYVLASFGILTEFFLLIMCLVMLISPAYWEYRDCLHQSLTVSDQQTCQDTYYRQATQLGTQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY02</accession>
    <name>A0A2Z5QY02_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87322">
        <property type="protein sequence ID" value="BAV87322"/>
        <property type="gene ID" value="RA11412_1023"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1023"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="61" mass="6347" checksum="ACAF073612023550" modified="2018-10-10" version="1">MSDPATKKLHAVNIADAKAPKTLVSVELPQTPNELSGTSSSKPAPTQDHGHGESHEGDHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY51</accession>
    <name>A0A2Z5QY51_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87395">
        <property type="protein sequence ID" value="BAV87395"/>
        <property type="gene ID" value="RA11412_1096"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1096"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="75" mass="8864" checksum="2DA3DD401FB5CC71" modified="2018-10-10" version="1">MGDGEYRDLVQEYQYPNLLNLGFIKFDPEWKKYVRDYVDIMLLPHRQGDPSCTYFESLGMGSRLQDSPTILSLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY89</accession>
    <name>A0A2Z5QY89_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid stabilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_04015</name>
        <name evidence="1" type="ORF">RA11412_1007</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87306">
        <property type="protein sequence ID" value="BAV87306"/>
        <property type="gene ID" value="RA11412_1007"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1007"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="144" mass="16151" checksum="AD660F77B5EEB47B" modified="2018-10-10" version="1">MKTSGILLDSDVLAEIRKATPDPRVVAFLRRRAWRHMYISVLSVGELKGLYPYPETDRWIAELLERFADHVITIDAKVSLEWAGRNAPIGYHSVGRADAAPLPTAALEGLICASARAYNLEIVSSKAEVYRRWEAVATNPWTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYC7</accession>
    <name>A0A2Z5QYC7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_04255</name>
        <name evidence="1" type="ORF">RA11412_0945</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87244">
        <property type="protein sequence ID" value="BAV87244"/>
        <property type="gene ID" value="RA11412_0945"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0945"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="425" mass="48353" checksum="AE9491B7D321C79E" modified="2018-10-10" version="1">MTASNKSTLNASRQDRYLKAVELLDSAHSYTRLGAVHALVGLADEYLANESLSAEEKHTEGQRIVDVLCAYIRDPFELAFRYDELSQNKPSQHGVYGDNHQDFYMHKAELLAEAKVRQQALQEIHRRLRHFPQDDRRSYVEGSWSGFEYDFSNSVFFYPVDMKDSWYQNSVDFSRCTYYTSAEFNGSTYERSAYFCDSTYYDWVFFNNSTYCGEAQWSGSTYHDSARFNWSVYYGEVSFHDSVYGGSVFFDQSLYYDEALFYSSTYRGEAGFDGSLYQGSVFVNDSVFAGEVSLYGSVFCGALNFGTDFFGESYPSRFVQSAPCFVAEKNARATLFGSSSNNFVVANSGYSIALGADGLPLGCSFLSTEQADYLAAKFRKIHETWTHLHDSQVPQERQDLREKMESLSQDIRAWRKEATALPGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYG4</accession>
    <name>A0A2Z5QYG4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ORF">RA11412_1087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87386">
        <property type="protein sequence ID" value="BAV87386"/>
        <property type="gene ID" value="RA11412_1087"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1087"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="41"/>
            <end position="214"/>
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        <location>
            <position position="34"/>
        </location>
        <ligand>
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        <location>
            <position position="36"/>
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        <ligand>
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        <ligand>
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        </ligand>
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        <location>
            <position position="82"/>
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        <ligand>
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        <location>
            <position position="112"/>
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        <ligand>
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        <ligand>
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        </ligand>
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        <source>
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    <sequence length="295" mass="31958" checksum="39AC45B91497CC77" modified="2018-10-10" version="1">MRENLNDKPLLGPQEIRDLAAQLGIRPTKTLGQNFVIDPNTIRRIVAAADITDDETVLEVGPGLGSLTLGLADAARQVVAVEIDPPLARQLPHTIAKFRPDKAQNVHVVLMDALKVTELPHMPDALVANLPYNVAVPVLLHLFAQFPSIRHALVMVQDEVADRLAAKPGSKNYGVPSVKASWYAEVFKAGVIGKNVFWPAPKINSGLVGFRMRPQPLADIDRDEVFTVIDAAFAQRRKTLRAALASWAGSGARAEAILTEAGITPTERGEKLDIHGYIRIAQAAHRVPALAADEN</sequence>
</entry>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="EMBL" id="BAV87502.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A2Z5QYL2_9MICC</name>
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        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_03115</name>
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    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="VEI22572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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            <begin position="29"/>
            <end position="50"/>
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    </feature>
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        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
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            <dbReference type="EMBL" id="VEI22572.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="147" mass="15480" checksum="DBDF7A3BEF0A51E2" modified="2018-10-10" version="1">MGNNLQSASGGRPQNRSMGSYHASGPGKLIAVLYGVFTLSAGARAGYQLVRKFDEAPLAILLSLLSAVIYAVAAVALARRGERARRVALVTISAELAGVLGVGALSLAAPHLFPLASVWSHFGQGYGFIPLVLPVVGLWWLFHSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYM6</accession>
    <name>A0A2Z5QYM6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87344">
        <property type="protein sequence ID" value="BAV87344"/>
        <property type="gene ID" value="RA11412_1045"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1045"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010539">
        <property type="entry name" value="UCP009160"/>
    </dbReference>
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        <property type="entry name" value="BaxI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="155" mass="17002" checksum="08BCC2FF50B10775" modified="2018-10-10" version="1">MAGNPFINSIIKKNRQGGDPRFGRFGAGGQAAQQNQYPQGQYQQNPYGAQYSSEPQQYQGGYPQGYGQPEYQNQPGYDQQYAQQPGYSPVIEGERLTMNDVIMKTGLSLAVVVLGAAVGWYMPILLVVGLIGGLVLGLVNGFKRKVSPVWCWHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYY9</accession>
    <name>A0A2Z5QYY9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_1396</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87695">
        <property type="protein sequence ID" value="BAV87695"/>
        <property type="gene ID" value="RA11412_1396"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1396"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="9">
        <location>
            <begin position="162"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="387" mass="42076" checksum="BEFB6B9498435F89" modified="2018-10-10" version="1">MKTAEQLARIEANKDAVATNPVLNNPRLAELTSWDAPWAGLRVVVVGLGVSGDAAADVLAQKGAHVVAIDAKDTAEKRERIRLYDQAYGHVSGLFGQEHMSSLPLVDGQEPDVVVVSPGIRPDSDIMLDAYERGVQVWSEVELAWRLNTRAGRRSTQWLCLTGTNGKTTTVGMVDSILKAAGRHSAQVGNVGLPIVYAVADDEEYEFFAVELSSFQLHWTYSLSPLASVVLNVADDHVDWHGSFEAYKAAKARIYENTQVACIFNEDHADTRRMVEEADVVEGARAVSISSTEIPRVSMLGLAEDILVDRAFLKDRYHQALELGVLTDLAQAPGQVPAQHTVENALAAAALTRAAGIAPEHVREGLRTYSQGRIVTSWWPQLAECSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZA3</accession>
    <name>A0A2Z5QZA3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptide-binding ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87825">
        <property type="protein sequence ID" value="BAV87825"/>
        <property type="gene ID" value="RA11412_1526"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1526"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="33"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="363" mass="39693" checksum="9BAAE0E13B5D2EF4" modified="2018-10-10" version="1">MSLDPALTPVTSTTRITSQILEPLVAANHYTGEPEPALATSWDISDDRRTYTFTLRENVKFSDGAALNTGAVLRNADRWRALATNTDTAHLCVPLFPLYGWGFGTAEKVETKQQSPSATPTPTATGSASPAESPQPTADPTASASAEPSASASGAAPHDSTQKEHATYRHQPLLQSVEEREGKIVMTLSRPSLAFLRMLTQPAFGILSPNCLDENSRIKDHPVGTGAFKVQSFEQARTVLVRNEHFKRDNTKVELDEIQFHTLSSSDKRYYSLVASKIDACDQVSRNDLAPLVREGYLTPTRDPFSLVYFDFNLEHPVLKNISVRRAIARAVERGTIVPYYLQGTSDALGTSPHYSAPATKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZC4</accession>
    <name>A0A2Z5QZC4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87574">
        <property type="protein sequence ID" value="BAV87574"/>
        <property type="gene ID" value="RA11412_1275"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1275"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="188" mass="20664" checksum="B5EC67C0521BDCB5" modified="2018-10-10" version="1">MILKWYRRQDSAKNSGGFGYLRERHGLVALGELAPGVFPHLYGADNALRCVALEDVAFADARAVGDALLPSTAQTPPGYLAFAVDSYLSVWNALAEAGVMPRAVERYRKALAKADRKAQHPGAMPSPALAENGLASLYPEADGLQVPEDVELEELGEQQQTLIEMAYRFRRVVQPFFTKRPRCLSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZF0</accession>
    <name>A0A2Z5QZF0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87671">
        <property type="protein sequence ID" value="BAV87671"/>
        <property type="gene ID" value="RA11412_1372"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1372"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="172" mass="18806" checksum="36D6A7BD52FF1A9A" modified="2018-10-10" version="1">MLFADPLSLVDENLGYRGSVARKAAGISYRQLDYWARTELVVPTVRSASGSGTQRLYSFRDVLVLKIVKHLLDTGVSLQQIRTSIEHLRTRGVEDLAGVTLMSDGTTVYECTSPSEVIDLVQAGQGVFGIAIGRVWREIEQNLNGEPGEDTLGGAHEHVDQLAARRARKVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZS8</accession>
    <name>A0A2Z5QZS8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yvcK</name>
        <name evidence="5" type="ORF">I6I94_01215</name>
        <name evidence="4" type="ORF">RA11412_1706</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88005">
        <property type="protein sequence ID" value="BAV88005"/>
        <property type="gene ID" value="RA11412_1706"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1706"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="354" mass="38210" checksum="A3C276E3B74F33BC" modified="2018-10-10" version="1">MSEGTNTPSHSSGSSKNVPKLPPLPTQALRLLKTTRRVPKVTALGGGHGLYGSLSALRHVTTDVTAIVTVADDGGSSGRLRNEMGVLPPGDLRMALSALCDDTDWGRTWSDVLQHRFSAPEGHTGEFPLDYHALGNLLIVTLWELLGDPVAGLDWVGALLNARGRVLPMALEPLVIQGIVLREHGGAFERVQVRGQVNLAHEPQVHNIELVPAQARACPEALASIEEADWVVLGPGSWRTSVLPHLLLREQCEALSTTNAKRCVVMNLALDDKESNGLDASAHLKLLQQYAPNLRLDVVIADPSNMGVQSEFEDAARELGAKVLWASVRSTTNPNVHDPLKLASAYNDMFAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZT5</accession>
    <name>A0A2Z5QZT5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nicotinamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87801">
        <property type="protein sequence ID" value="BAV87801"/>
        <property type="gene ID" value="RA11412_1502"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1502"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="90" mass="9790" checksum="C297915C064E3005" modified="2018-10-10" version="1">MTGEHEPGATLDDEGPKTPLADWLDEHEIQDVDIVGIATDYCVLATAKDAVDAGYETRVLIDLTAPVHENKLDEIIAEMEDEGITVKQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZU9</accession>
    <name>A0A2Z5QZU9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88025">
        <property type="protein sequence ID" value="BAV88025"/>
        <property type="gene ID" value="RA11412_1726"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1726"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="66" mass="7527" checksum="625BFAD822BDCBB8" modified="2018-10-10" version="1">MSVEIPEVLRPKMKGSTVLAKNLRALEGLRPHPTELAEKARQHAQNLLDKRLSRDITVKKEERNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZZ0</accession>
    <name>A0A2Z5QZZ0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_1531</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87830">
        <property type="protein sequence ID" value="BAV87830"/>
        <property type="gene ID" value="RA11412_1531"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1531"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="151" mass="16489" checksum="8D0AB28DB9017F69" modified="2018-10-10" version="1">MLSRVSGLFSRRMFNIASLAVGPTEVPKVSRITIVADGDSETLEQLTKQLNKLIHVLKVVELLPETSTQRDHIMVKVKADPAVRLQVVQAADLFRASVIDVSTESVVIEATGSAEKLNALLDVLEPYGIREIVRAGTIALSRGPRSMSERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZZ3</accession>
    <name>A0A2Z5QZZ3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_1485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87784">
        <property type="protein sequence ID" value="BAV87784"/>
        <property type="gene ID" value="RA11412_1485"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1485"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="160" mass="17316" checksum="7E0AD87BE947687E" modified="2018-10-10" version="1">MTNPVKLGFLGTVGVGLALLAYYAFTNVGALAGWVTGAVFIALGLDPAVRRLEKWGIRRGVGVLLVVTVFAGTVTGLTLWIVPIISEQANSFIYRSPAIFRISWSQRRSKTLTIWCTSATGSIRMCPRSLSLLHPATRLAGSWGTWLQQDPQSLRCSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R066</accession>
    <name>A0A2Z5R066_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">secG</name>
        <name evidence="12" type="ORF">I6I94_01180</name>
        <name evidence="11" type="ORF">RA11412_1714</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88013">
        <property type="protein sequence ID" value="BAV88013"/>
        <property type="gene ID" value="RA11412_1714"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1714"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV88013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT89282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="86" mass="9094" checksum="A1CAB0AC41E0D4FF" modified="2018-10-10" version="1">METLMTVLMVIIAITSVIAVLLVLLNRGQGGGLSDMFGGGMTSSLNSSGMASKNLIRLTVTVSIIWVAAIVLYGLALRFNGQYVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0D7</accession>
    <name>A0A2Z5R0D7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">aroC</name>
        <name evidence="11" type="ORF">I6I94_00550</name>
        <name evidence="12" type="ORF">NCTC10207_01193</name>
        <name evidence="10" type="ORF">RA11412_1888</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037233519.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88187">
        <property type="protein sequence ID" value="BAV88187"/>
        <property type="gene ID" value="RA11412_1888"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1888"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="257"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="316"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VEI23096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="405" mass="42463" checksum="AB885B5C07341B1C" modified="2018-10-10" version="1">MALRWLTAGESHGEALVGIIEGVPAGVELTSEMVRDALARRRLGYGRGARMKFEEDKVRILGGVRHGVTQGGPIALEIANTEWPKWVDVMSSDPVDPALIEGRARNAALTRPRPGHADFTGMQKYNFAEARPVLERASARETAARVALGVVAAQVLKALGVELVSHTVAVGGVHAPDGAPVPTPNNVQSLDADPLRCFDAATSQAMVARVDEAHKDGETLGGVVEVLAYGMPPGLGSYVHWDRRLDARLAAALMGIQAIKGVEVGDGFATADRPGTAAHDEISVGEHGVKRDTNRAGGIEGGMSIGDLLRVRAAMKPIATVPKALKTIDTSTGEPATAHHQRSDVCAVPAAGVVAEAMVALVLAQAALEKFGGDSMGETRRNMDAYLAAIPESLAWESNVAGWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0J6</accession>
    <name>A0A2Z5R0J6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical ATP-binding protein UPF0042</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88004">
        <property type="protein sequence ID" value="BAV88004"/>
        <property type="gene ID" value="RA11412_1705"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1705"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="145" mass="16353" checksum="71638EDA4D1CF8AF" modified="2018-10-10" version="1">MNVHELARTVREMFAEGADKKLNLSVMSFGFKYGAPADANYMADMRFIPNPHWIPELRPLTGLDAPVRDYVLQNTGTEEFISNYLAALRPVLEGYRREGKYYATLAIGCTGGKHRSVAVTEEIARRLGELPEVNVNVLHRDKGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0L0</accession>
    <name>A0A2Z5R0L0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">clpB</name>
        <name evidence="14" type="ORF">I6I94_07775</name>
        <name evidence="13" type="ORF">RA11412_0100</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86399">
        <property type="protein sequence ID" value="BAV86399"/>
        <property type="gene ID" value="RA11412_0100"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0100"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="12">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="398"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV86399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT88430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="863" mass="94137" checksum="C93225F6EEEC6C4A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0L7</accession>
    <name>A0A2Z5R0L7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">efp</name>
        <name evidence="12" type="ORF">I6I94_00565</name>
        <name evidence="13" type="ORF">NCTC10207_01190</name>
        <name evidence="11" type="ORF">RA11412_1884</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887304.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88183">
        <property type="protein sequence ID" value="BAV88183"/>
        <property type="gene ID" value="RA11412_1884"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1884"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV88183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT89166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VEI23093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="187" mass="20475" checksum="F782FEF4ECA0D6C0" modified="2018-10-10" version="1">MATTTDIKNGAVLKIDGNLWSVVEFQHVKPGKGGAFVRTKLRNITSGKVVDRTFNAGAKIETATVDRSDYQYLYQDGEDYVFMDMKTYDQINVPATVVGDAANYMLESQTATIAMNEGNPLYIELPASVVLEITYTEPGLQGDRSTGGTKPATVETGYEIQVPLFLETGTKIKVDTRTGDYLGRVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0P9</accession>
    <name>A0A2Z5R0P9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88317">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="131" mass="14036" checksum="63AC96EF6B8806C3" modified="2018-10-10" version="1">MRAVSVLRMTGTVKCASPEPTDRSPSVTRREIRPFTPPVNQPSGSFASWSPTLIRRRRRASNAARYELNVIAYVVTAPTTASTASVMSQPLSPIPQVGFPVAIVPAVGIITKYTKPSITPAATISVSDRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0R1</accession>
    <name>A0A2Z5R0R1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_00995</name>
        <name evidence="6" type="ORF">RA11412_1777</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SURF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88076">
        <property type="protein sequence ID" value="BAV88076"/>
        <property type="gene ID" value="RA11412_1777"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1777"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="PTHR23427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="320" mass="36411" checksum="9988334E28A3FC3D" modified="2018-10-10" version="1">MRAYRFLLTSKWILAFILCVLFSVLCVYLAGWQMSRKEALDWRNSLIVQNYHADPYRLEDKPRIFTDYDPNTQWHPVQMRGQYLPEKTLLARNRPYEGQNGFEVLVPFRTDDGQVIVINRGWLPASSSDAAAPREEVPAPPQGQMSIVARVHNGESATGKEAPQGQVASIDLKEIAERTSLPVSAGAYGLLDAENPAAASRPQQKAQPELDNGPNLSYSLQWYAFAVLIYVVYFWSARQKVRNDELDAQVAAELERYYGQFYNEDGTYVGEEDEAVVLRKMEMIDDMPSHMKSIVRPRPARKRSRPTDEEEEDAFLDGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0T5</accession>
    <name>A0A2Z5R0T5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88348">
        <property type="protein sequence ID" value="BAV88348"/>
        <property type="gene ID" value="RA11412_2049"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2049"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="45" mass="4851" checksum="71E8887DC1E6BCD5" modified="2018-10-10" version="1">MYAQGRFSYDCVPGGAAGDMLTPGRWCWQVRGVPSLTVANTAVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0T7</accession>
    <name>A0A2Z5R0T7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster assembly accessory protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Probable iron binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00890</name>
        <name evidence="2" type="ORF">RA11412_1802</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887213.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88101">
        <property type="protein sequence ID" value="BAV88101"/>
        <property type="gene ID" value="RA11412_1802"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1802"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="118" mass="12869" checksum="DBF74437541C4F65" modified="2018-10-10" version="1">MTEAVATELPTHGVNLTEVAQNKVRTLLEQEGRTDLRLRIAVQPGGCSGLIYQLYFDERVLDGDAVRDYEGVQVIVDKMSAPYLDGSTIDFEDTIEKQGFSIDNPNAAGSCACGDSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0V7</accession>
    <name>A0A2Z5R0V7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2183 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00190</name>
        <name evidence="2" type="ORF">RA11412_1984</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88283">
        <property type="protein sequence ID" value="BAV88283"/>
        <property type="gene ID" value="RA11412_1984"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1984"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="DUF2183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2183" evidence="1">
        <location>
            <begin position="224"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="367" mass="41157" checksum="A8D14188E643A267" modified="2018-10-10" version="1">MENLGTHELRTMVTEAADEAVNIGYRVGDTLHRWRERRAIAQGQEPIIVPSEGYGRVATGAKNGWVRILARALYKTEAFEKLLYVVEGTQDTDNPMRGWRAFTSIAMSDAPVTIIIAGRTYEVRTDRGGVLDVKLDIDLPAGLHEVIMYVPGSRAAVTSVYIVPAEQKIGVIADVDDTVMVTMLPRPLVAAWNSFVIDEHARIPTPGMAVLMDRIRAAHPQAPFMYLSTGAWNITPTLRRFLTRNGYPRGTFLLTDWGPTPDRWFRSGTQHKVQSLRRLAHEFPEMQWILIGDDGQRDPDIYNGFAVRYPQNVAAIMIRNLTVGETVLASGRVWGDKRAQQMTQSPLWMEANDGDTLSCKLRQRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Z0</accession>
    <name>A0A2Z5R0Z0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_0240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86539">
        <property type="protein sequence ID" value="BAV86539"/>
        <property type="gene ID" value="RA11412_0240"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0240"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="136" mass="14799" checksum="0CDAC0492F6E22E9" modified="2018-10-10" version="1">MLNIITGRGSKSGEYMLHHKGFNKLAFTGSTEIGRHIGIAAAEMLIPSTLELGGKSANIFFDDMPFDKALEGAQKGILFNQGQVCSAGSRVFVQEGIYDKFVNALAEEFKKSKSACLGKTIPKWVRKSTPVSLKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Z2</accession>
    <name>A0A2Z5R0Z2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ruvB</name>
        <name evidence="6" type="ORF">RA11412_1911</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88210">
        <property type="protein sequence ID" value="BAV88210"/>
        <property type="gene ID" value="RA11412_1911"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1911"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RuvB_N" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_4" evidence="5">
        <location>
            <begin position="67"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="182" mass="20431" checksum="3417EE02CABD80FD" modified="2018-10-10" version="1">MSRPAEEMLYMAMEDFRVDIVVGKGAGATSIPLELPQFTLVGATTRAGLLPGPLRDRFGFTGHLEFYSVPELELVLRRSAGLMDMSITSEGFAEIAGRSRGTPRIANRLLRRVRDWALVNDVPNINAHNAATALDMYEVDERGLDRLDRAVLESLIHKFGGDRWGYPPWLSPLVKKPRPWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R159</accession>
    <name>A0A2Z5R159_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86619">
        <property type="protein sequence ID" value="BAV86619"/>
        <property type="gene ID" value="RA11412_0320"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0320"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M13_N" evidence="1">
        <location>
            <begin position="20"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="486" mass="55734" checksum="E692B10F83099AA4" modified="2018-10-10" version="1">MDNTKKSGIVTEWVDSNVKPGDDFFRHVNGAWLDTYEIPADRSKDGGLYTLRDDAEKHVREIIERVAKEQPASRIGALYNSFMDTKKIEADGLDPLLKEVAPILNAQTPQQLAVTLALLSRAGISQLIGWYTSIDSKDPQKYTFYMTQSGLNLPDEAYYREEKYEQVCSAYIDHIARVFELTGLAEGFSLTPAEAAKLIFAHEAEIAAHHWDVVANRDAEARYNPVDAAELEEKFPGFQFSHWLRALGADPDSMGKVVVSQPSFFEGVARLWEQTPLLTWKLWAVWNAVHSRAPFMYDELVQANFDFYGRTLSGTEKLRDRWKRGVGTVEKALDQEVGKEYVAVHFPPEHKAKMLKLVDNLLEAYRRSITNLEWMTEATRAKALEKLSMFVTKIGYPDEWRDYSKLELVEGDLFENLRRASAFDCDFMLERNGQPVDQNEWLMSPQTVNAYYMPRRMRSCSRPLFCARRSLTPRPTTQQTTVVLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R197</accession>
    <name>A0A2Z5R197_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86659">
        <property type="protein sequence ID" value="BAV86659"/>
        <property type="gene ID" value="RA11412_0360"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0360"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="55" mass="5591" checksum="6484DF743513F739" modified="2018-10-10" version="1">MGFHLSGGTGGVSWAGPGGVRKSPEGEVLGVNHDGASVLLSADHHHMTIIKKDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R199</accession>
    <name>A0A2Z5R199_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_1965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88264">
        <property type="protein sequence ID" value="BAV88264"/>
        <property type="gene ID" value="RA11412_1965"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1965"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="488" mass="55308" checksum="4E9D4BA2AA71F3C2" modified="2018-10-10" version="1">MHQEQNITHTLNTQPIPMVKPHAEFPPGFLWGGATAANQCEGAWDKDGKGPSIQDVLPRGGFNPRTATPTPDNLKLEGIDFYHRYPEDIALLAEMGFKVFRFSIAWSRIFPHGDETEPNEAGLAFYDGLLDELEKYGIEPLVTISHYETPLHLAEKYNGWVSRKLISFYERYCRVLFERYGHRVKYWLTFNEINSVLHVPFMSGGINTPKEQLTEQQLYQAIHHELVASARATRLARELAPDARIGCMILAMPTYPLTPSPDDALAALHAEQANYMFGDVHVRGAYPGYFMRQLADKGVQLEITEQDRQDLKNTVDFVSFSYYMSTCASGSPARGEREAGNMLGGVSNPHLSASEWGWQIDPVGLRIVLNQYWDRWQKPLFIVENGLGARDELVEANGELTVLDDYRIEYLRAHLLQVREAIADGVQLLGYTTWGCIDMISASTAQMSKRYGFVYVDRSDDGSGTLARYRKKSFDWYRRVIASNGTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1A6</accession>
    <name>A0A2Z5R1A6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86669">
        <property type="protein sequence ID" value="BAV86669"/>
        <property type="gene ID" value="RA11412_0370"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0370"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="45" mass="5022" checksum="EB2023D80877ABAE" modified="2018-10-10" version="1">MNTPENAHTITKAAAHPLNITRSLRRFRNGNNLATETLTPTHPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1B1</accession>
    <name>A0A2Z5R1B1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88468">
        <property type="protein sequence ID" value="BAV88468"/>
        <property type="gene ID" value="RA11412_2169"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2169"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="151" mass="16854" checksum="11A54546B7829BC9" modified="2018-10-10" version="1">MEYLGRPADSLAHYEDMVVRARADYEREGFCLYTVLADGEVAGFTGAHRWVNDWGPTGQIELAWRLGCAFWGEGIATRAARQVMGELADARHQQVYAVIHTHNRASAAVAQRLGMHQRSSYEAQVNGLALPVTEWVTNLYRPGTKPEPEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1D8</accession>
    <name>A0A2Z5R1D8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trk system potassium uptake protein TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88482">
        <property type="protein sequence ID" value="BAV88482"/>
        <property type="gene ID" value="RA11412_2183"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2183"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="80" mass="8447" checksum="60390E06F13863B4" modified="2018-10-10" version="1">MPHFVIMGAGRVGVMLARTLEASGHTVAVIDQDIRAFQPLRKNFGGKLVTGVGFDKETLERAGIEGAYAFAAVSSGIIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1E5</accession>
    <name>A0A2Z5R1E5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AlbA_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86709">
        <property type="protein sequence ID" value="BAV86709"/>
        <property type="gene ID" value="RA11412_0410"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0410"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlbA_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="90" mass="9897" checksum="E4545F4F8B7227BF" modified="2018-10-10" version="1">MYTPEEVTQTLNELRLLGRDSLTVEVKSAHNGYPSSIAETICSFANLPDGGTIICGVDEAQDFAPVGVYDLEDLRAKLLTPRRISNQKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1E9</accession>
    <name>A0A2Z5R1E9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3710 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_10695</name>
        <name evidence="2" type="ORF">RA11412_2193</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037235092.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88492">
        <property type="protein sequence ID" value="BAV88492"/>
        <property type="gene ID" value="RA11412_2193"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2193"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022183">
        <property type="entry name" value="DUF3710"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12502">
        <property type="entry name" value="DUF3710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="288" mass="32510" checksum="CD00D7F99A1EBDFF" modified="2018-10-10" version="1">MFGFSKKKRAEEEYDVEEYDEYDDYDEYDEYDDYDDYDEAEDTEGIDEDEYDTEEEDKADPVPAYVEDESLKVIVYDRTEGPLDMDEVEDTEDYANLGSVYIKLLDGMRLRLEVEEASGVVIAATCIRKGATIQIQAFAAPRSSGIWDDIREELAESVASQGGTVEMYEGVFGVEMLTRLPAVTEDGKRGERVARFVGVDGPRWFLRGVISGEAVLDNEEAAEAIDEVFRSVIVDRGDEPRPPRELLPLVVPAQDIATADDEDEPEEQDDKSKLRPLPRRGPEITEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1G6</accession>
    <name>A0A2Z5R1G6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">ettA</name>
        <name evidence="11" type="ORF">I6I94_11215</name>
        <name evidence="12" type="ORF">NCTC10207_01335</name>
        <name evidence="10" type="ORF">RA11412_2057</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887972.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88356">
        <property type="protein sequence ID" value="BAV88356"/>
        <property type="gene ID" value="RA11412_2057"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2057"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="5"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="324"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Arm" evidence="7">
        <location>
            <begin position="94"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="356"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VEI23235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="559" mass="62107" checksum="C40C322EC18B0EE3" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1P3</accession>
    <name>A0A2Z5R1P3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="8">UPD</shortName>
            <shortName evidence="8">URO-D</shortName>
            <ecNumber evidence="4 8 9">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 14" type="primary">hemE</name>
        <name evidence="14" type="ORF">I6I94_09990</name>
        <name evidence="13" type="ORF">RA11412_2358</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 8 9"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88657">
        <property type="protein sequence ID" value="BAV88657"/>
        <property type="gene ID" value="RA11412_2358"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2358"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="11">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="12">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="63"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV88657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT88841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="383" mass="41168" checksum="9BDEBFBABBC07568" modified="2018-10-10" version="1">MTKTSPVPCPPHPAERQRDLLTEAQLSRLSASHPLRAAQTADSPMLQALTGRASEHRPVWFMRQAGRSLPEYRKAREGIPMLDACLTPELAAEITVQPVRRHNVDAGIFFSDIVIPMKLAGVNVDIVPGRGPVLENPVRTLDEVHALPELTDAALDPIREAVAATVEMLGSTPLIGFAGAPFTVAAYMVEGGPSRDHLRPRTMMHADPVAWRELAQWAARTAGQFLRAQIEAGASAVQLFDSWAGSLGEADYRRYVQEHSAAALGMVEEFGVPRIHFGTGTAELLPAMHEAGADVIGVDYRLPLDEANRRLNGAVPLQGNIDPALLSAGREALYAHADEVLAAGASAPAHIVNLGHGVPPTTDPQVLTDLVAYIHEHPTNSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1R6</accession>
    <name>A0A2Z5R1R6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type amino acid transport system</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Amino acid ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">L-cystine transport system permease protein tcyB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tcyB</name>
        <name evidence="9" type="ORF">I6I94_09895</name>
        <name evidence="10" type="ORF">NCTC10207_01621</name>
        <name evidence="8" type="ORF">RA11412_2388</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037234821.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88687">
        <property type="protein sequence ID" value="BAV88687"/>
        <property type="gene ID" value="RA11412_2388"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2388"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="20"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VEI23577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="227" mass="24494" checksum="7D7560F1F222FC8F" modified="2018-10-10" version="1">MSFFDQLGALLAKYDVVGAFWVNVQLTFWAAIGSFVLGSVLALMRISPVPSLRFVGTAYVNAVRNTPLTILMTLALLGVWTQFQLSFSTSFETNFFVYAVIVLSIYHASFVCEAIRSGVNTVPTGQAEAARAIGLGFFPTARHVIFPQALRGSITPLGNTLIALAKNTTVASVASVAESSGLMKTMIEFDPNMVLAIFLMFALGFVVIVVPLGVLTTWSSRKLAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1S2</accession>
    <name>A0A2Z5R1S2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-deoxy-D-xylulose 5-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88474">
        <property type="protein sequence ID" value="BAV88474"/>
        <property type="gene ID" value="RA11412_2175"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2175"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="4973" checksum="E029140CBE5DBD3A" modified="2018-10-10" version="1">MPEKTVPGENAKPEMLHGIHDPKDLRPLTYEQLRELAGRSGSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1V2</accession>
    <name>A0A2Z5R1V2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88451">
        <property type="protein sequence ID" value="BAV88451"/>
        <property type="gene ID" value="RA11412_2152"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2152"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="68" mass="7222" checksum="FB5B9D7E98165E99" modified="2018-10-10" version="1">MTCSPHAAETQNIVAEALESGKVHLLDARTALQAVALQESGSGEPGMTARLGACWRGRKTPEPSLRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1V3</accession>
    <name>A0A2Z5R1V3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Permease protein of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_09890</name>
        <name evidence="8" type="ORF">RA11412_2389</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88688">
        <property type="protein sequence ID" value="BAV88688"/>
        <property type="gene ID" value="RA11412_2389"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2389"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="77"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="311" mass="34035" checksum="E73EDDD05940E97D" modified="2018-10-10" version="1">MKLLNSKLDTSTSVLFDTPGPRAKAMTRWFNIGAIVLLAAFMAYVLSVMGAKGQLEAEKWTDLFTAKAWGSYYLPGLLATLQAAGISVVTSVVFGVLFGMARLAQNRPMRWFGTVVVEFFRAVPVLMMMIFFWLFLSRFSWINPAQLPFFAVVIGLTLYNGSVIAELLRSGVKQLPRGQGEAGLAIGLTPGQTLRTILMPQAFNAMMPSMLSQFVVILKDTALGYIISYPELLASARRIGSGDGNILQTLLLAAVLFIAVNFSLTTFATWLGGFLSSRTSVTPKKMHHLPGEVDTPNPPTQQMFVLPGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1W2</accession>
    <name>A0A2Z5R1W2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88737">
        <property type="protein sequence ID" value="BAV88737"/>
        <property type="gene ID" value="RA11412_2438"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2438"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="54" mass="6229" checksum="0477BCFAAD18EE36" modified="2018-10-10" version="1">MVQESILTFRDKKTLGYQLQNAGFEIHAVWGDWCRTPFDGTQPIMVFEAVVPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R200</accession>
    <name>A0A2Z5R200_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2476</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88775">
        <property type="protein sequence ID" value="BAV88775"/>
        <property type="gene ID" value="RA11412_2476"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2476"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="4">
        <location>
            <begin position="38"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="298" mass="32425" checksum="55E41553413B3587" modified="2018-10-10" version="1">MSNQNIVKYAVLETCLFCGHSLLMYAVCMTNVSGSITKAVIPAAGLGTRFLPATKATPKEMLPVVDRPAIQYVVEEAIRAGLQDVLMITGRNKRALEDHFDRVPVLERQLAEQGKEALLKAVEESNYLGEIHYVRQGDPKGLGHAVLRGKVHVGNEPFAVLLGDDLIDEKEDLLSRMVEVQQRTGGSVVALMEVPREAISAYGAAAIETVEGEDFVKVTGLVEKPEPEQAPSNYAVIGRYVLSPKVFEVLENTAPAVAGKFSSLTPCRLLPWARAMGKACMAWCLRAVVLILVISSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R249</accession>
    <name>A0A2Z5R249_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine_BP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86969">
        <property type="protein sequence ID" value="BAV86969"/>
        <property type="gene ID" value="RA11412_0670"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0670"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="53" mass="5798" checksum="E5985ED487B12A90" modified="2018-10-10" version="1">MDVIRRATEVVGKHGPRVSLVIKADIRPGHDHGEIEGKVQRLNAAIEQLDSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R265</accession>
    <name>A0A2Z5R265_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">map</name>
        <name evidence="6" type="ORF">I6I94_09210</name>
        <name evidence="5" type="ORF">RA11412_2546</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88845">
        <property type="protein sequence ID" value="BAV88845"/>
        <property type="gene ID" value="RA11412_2546"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2546"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="14"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="279" mass="29942" checksum="3E7A74D4AC0321A7" modified="2018-10-10" version="1">MARVEIKTNAQLAHMSRAGLITSRALDAAVAAAQPGVSTAEINRVFEESLQEQGGTSNFYGYYDYPASICTSVNHEVVHGIPGDYRLKEGDILSIDGGAYIIDPATGKQWHGDSARTVLVGEVSQERRELSDITRAAMWHGIAALATAKKVGEVGVAIEGFVREQAGDKYGIIEDYVGHGIGTQMHMRPDVLNYAARDLGPKIKPGMAFAIEPMLVTGGIATRVLQDDWTVVTADGSDACQWEHSVAVHRDGIWVLTAQDGGAKELAELGVEVREIPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2A4</accession>
    <name>A0A2Z5R2A4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DJ-1/PfpI family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">ThiJ/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09745</name>
        <name evidence="2" type="ORF">RA11412_2423</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88722">
        <property type="protein sequence ID" value="BAV88722"/>
        <property type="gene ID" value="RA11412_2423"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2423"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="10"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="210" mass="22438" checksum="F57807EEB6BDC3F3" modified="2018-10-10" version="1">MSGGEKPAVHIYCLLFDGYETLDLMGPVEFLHGVPGARLHYVSHLGGAVRSTQGFSVATEPLGELKPGSVLLIPGGAGTRTLVHDTDFVEALTRWVQQSEYCLSVCTGSALLAATGLLNGLEATTNKRAFDWVRGTNPPVLWQGTARWTHSGKFYTSSGVSAGMDMTLGFIADIAGIDEAQVQAHRCEYLWNQDPSHDPFSASSAPSPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2H3</accession>
    <name>A0A2Z5R2H3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Recombinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_09610</name>
        <name evidence="5" type="ORF">RA11412_2451</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88750">
        <property type="protein sequence ID" value="BAV88750"/>
        <property type="gene ID" value="RA11412_2451"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2451"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="4">
        <location>
            <begin position="137"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="489" mass="54506" checksum="ED8367AF6E2DA95B" modified="2018-10-10" version="1">MVTIECQREDYEKLAAFCGWEVVETYVDQSISASDKTKKHPAYLRMVQDYEAGLLDAIVCYGLDRLTRQPRELEDWIDRAESRGLLLVTANGDADLGTDGGRMYARIKAAVARAEVERKGARQSRAHVQRARQGRPPKGVRPMGYTTAGELIPHEAEAVRAIYAAFLRGDSLHGIARALSGAQADGEGAGVPRISLHSRTIVLERNARRQAEGKNPRPVPDDKPWSPSTVLGILRNPRYAGYSVYTSKDVRRQEAGESRRKALRDNLVKDENGELVLGQWEAIVEADEWWTVQNLLDDPARVTNRSGSTMRKHLGAGLYRCEVCGEPVRTRARYYSCNAGHLNRTRDAIDDFVRALVVARLQKKDLKRRKKQADPEVKDVFSEQIAQQRARIARAERDYDAEVIEGADLARIRAAARAEITRLEAERLVSGTGTMLAPILGTPDPAAAFLGAPIALQRTMIDTLMTVTLRRAKQGKKGFDPESVEVVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2H9</accession>
    <name>A0A2Z5R2H9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88676">
        <property type="protein sequence ID" value="BAV88676"/>
        <property type="gene ID" value="RA11412_2377"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2377"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="74" mass="8075" checksum="B81FD928DDEC9A43" modified="2018-10-10" version="1">MPLKTTIEQDVRKAASTVEGITRVQVEVGAMNADQRSALKSQLKPERTNPFTAPGRSPACLPWSPARAGWVSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2I1</accession>
    <name>A0A2Z5R2I1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trxC</name>
        <name evidence="7" type="ORF">I6I94_08695</name>
        <name evidence="8" type="ORF">NCTC10207_01867</name>
        <name evidence="6" type="ORF">RA11412_2668</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887715.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88967">
        <property type="protein sequence ID" value="BAV88967"/>
        <property type="gene ID" value="RA11412_2668"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2668"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI24025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="123" mass="13608" checksum="9CD9A313701A5A01" modified="2018-10-10" version="1">MATIEITQQNLLPTVQENDIVFLDFWADWCGPCKQFSPVYEAASEKYSDITFGKVDTEDQGQLAQDAGITSIPTIMGFREGILVYSQPGALNESQFEQVISSIRELDMDKVHAEVAAAEKAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2L6</accession>
    <name>A0A2Z5R2L6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">rplF</name>
        <name evidence="8" type="ORF">I6I94_09175</name>
        <name evidence="9" type="ORF">NCTC10207_01766</name>
        <name evidence="7" type="ORF">RA11412_2553</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88852">
        <property type="protein sequence ID" value="BAV88852"/>
        <property type="gene ID" value="RA11412_2553"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2553"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="90"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VEI23845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="178" mass="19130" checksum="3E6886B8172F3C65" modified="2018-10-10" version="1">MSRIGRLPISIPAGVEVKVDGNLVTVKGPKGELSHTVAAPITVALNENEITVSRPNDERLSRSLHGLTRTLIQNLIIGVTQGYEKKLEIVGTGYRVTAKGKDLEFALGYSHSINVEAPEGISFTVEGPNKLTVSGIDKQQVGQVAANIRGLRKPDPYKGKGVRYAGEHIRRKVGKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2M6</accession>
    <name>A0A2Z5R2M6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-methyladenine DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_04610</name>
        <name evidence="1" type="ORF">RA11412_0850</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87149">
        <property type="protein sequence ID" value="BAV87149"/>
        <property type="gene ID" value="RA11412_0850"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0850"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="309" mass="35923" checksum="36062729A07A34E4" modified="2018-10-10" version="1">MAEVLKVLNGPQWRTYARVHERRAGRFADPFVRRREQGQAHPVEDFLFTYYTLKPGQFKRWHPGAGVILLEAAERVSWKFYRAATEDELVLAGLSPDDAHTHAERGDAILVDIPQFVDKRGTALTFTREILSNTADKKAFFGCFGMHEWAMAYKSVQNNIRHDYLDLRLGAEGTDRVVESHRIRCSHFDAFRFFMPQAAPMNELQPTRETQRTMEQPACLHANMDIYKWAYKLIPLIDSALVMDCFELAWDARELDMRAAPYDLLDWGYEPIKVETPEGKAEYVQYQRELSERSVALRRRLLTTINTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2N2</accession>
    <name>A0A2Z5R2N2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88794">
        <property type="protein sequence ID" value="BAV88794"/>
        <property type="gene ID" value="RA11412_2495"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2495"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="88" mass="9319" checksum="EB7A582C857C411A" modified="2018-10-10" version="1">MVHASSVDANARFYVYMYAVRAIPAGIAVLIAPFYFRGGAVSLLLVTFAVMQVGDALIGCTRKEWGMVLFPSLSAVIHTVVACAVPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2N4</accession>
    <name>A0A2Z5R2N4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Naphthoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89025">
        <property type="protein sequence ID" value="BAV89025"/>
        <property type="gene ID" value="RA11412_2726"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2726"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010198">
        <property type="entry name" value="DHNA-CoA_synthase_MenB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="PTHR43113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="144" mass="15817" checksum="CADF1F0C7D3B273D" modified="2018-10-10" version="1">MTVTFPPQVSDIFNPQHWRIVDGFEDFTDITYHRQVQRDETGEILRDLPTVRIAFNRPEVRNAFRPHTVDELYRALDHARMTSDVGAVLLTGNGPSPKMAGGRSARAVTSASVGATATTTPAATPPNLLTLHVLGGCIFWRCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2P6</accession>
    <name>A0A2Z5R2P6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Duplicated ATPase component YkoD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89037">
        <property type="protein sequence ID" value="BAV89037"/>
        <property type="gene ID" value="RA11412_2738"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2738"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="162" mass="17515" checksum="765EE1E25B56758D" modified="2018-10-10" version="1">MPSWNPAQLLGRIGYVFQEPEYQFVRGTVREELQLGPRRLAALRREPVDEGALAAATESLAERLRLSGLLGANPFTLSGGEKRRLSVASALATAPRVLILDEPTFGQDAHTWGELVRIIRGLLAEGTAVLSITHDMEFTAALGGRSITLDAPARDAQEGNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2T8</accession>
    <name>A0A2Z5R2T8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-formyltetrahydrofolate cyclo-ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88776">
        <property type="protein sequence ID" value="BAV88776"/>
        <property type="gene ID" value="RA11412_2477"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2477"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="99" mass="10760" checksum="5D5505ABECF12A51" modified="2018-10-10" version="1">MGIAEPEGDAEGPHAFTAADLRLVPALAYGRNGRRLGQGGGYYDRLLPRLSEQALRETTVGVVFADEVLDSIPYDTWDGVLYRVLTENGVHPLGEHATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2U1</accession>
    <name>A0A2Z5R2U1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfur carrier protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiS</name>
        <name evidence="2" type="ORF">I6I94_08365</name>
        <name evidence="1" type="ORF">RA11412_2749</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023133218.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89048">
        <property type="protein sequence ID" value="BAV89048"/>
        <property type="gene ID" value="RA11412_2749"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2749"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="65" mass="6710" checksum="DF7830680D96F667" modified="2018-10-10" version="1">MKITYNGELLDISATNLEALILQQAGTDQGVAVALDGAVVPRSRWASTEVPEGARVDALTAVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2V3</accession>
    <name>A0A2Z5R2V3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88781">
        <property type="protein sequence ID" value="BAV88781"/>
        <property type="gene ID" value="RA11412_2482"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2482"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="341" mass="37006" checksum="542FF14071917103" modified="2018-10-10" version="1">MNGTPETPQGAPRTGNSPTSEPAPAPNPDGPPEALPPHLDPASHSFDPAAGLERWAEQMDIYTGPDAMLNFNRVDYVHIDLTAANPSGLAQLLAGRKTRLSTILREKSLLEEGMRAARTLRTKIYELSTDHGLDSGYFVAGTASWLSRSTREHTVSYEKRFIAPILMAPLSITPHPSSDDYELRLAGAARLNPAMVRQIKQEYDIDLGTMDVAQLANSMSRLDPEPVIERMRATTGNIPGMAIESRFFISTFADLKESMGELPHTAHTPLVRDIAALKVPGVQPSIRPLVQNQPPHDDRNPQRETQLLDADPAAQTIIDAAASGNSFTVTAAPAPSRYAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2W6</accession>
    <name>A0A2Z5R2W6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_2585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88884">
        <property type="protein sequence ID" value="BAV88884"/>
        <property type="gene ID" value="RA11412_2585"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2585"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="9">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="7">
        <location>
            <begin position="128"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="8">
        <location>
            <begin position="547"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="659" mass="71870" checksum="1A886C97D9880DE6" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Y2</accession>
    <name>A0A2Z5R2Y2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87249">
        <property type="protein sequence ID" value="BAV87249"/>
        <property type="gene ID" value="RA11412_0950"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0950"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="359" mass="40221" checksum="320EB078F908FDCC" modified="2018-10-10" version="1">MRKVAHCLGSALTVLDGMRAVPPFGGSSQRDSIARACEKQTHRAQQLTEDARALQHRVAGARTTAAALGRAGTPTATVPPTFITYAAAAQELAHRALTLSEWADRRLDEEKYGNGASGQTEQLWHLCLQADMYSDAAARLIKPALQYVEEMEKHLTAETYFSWYEYAQKVVRTIRTNLTHRNIPIMDRVLEKLNALEASLSLKGANAVPAAVLVQEAILLSDDVCYCILPDDPSDALIDYILDSCAEDDSDSLQAKERITYRANDWLPLPPRYQGRLEWLRQTAFDRPVLPILFQNVCEYRLADQQIRESLHAAYPQIHASGPDSPQAVQALTEAIQAHIFCPLEALRHEHLRFMRKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Z1</accession>
    <name>A0A2Z5R2Z1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">rplL</name>
        <name evidence="9" type="ORF">I6I94_08920</name>
        <name evidence="10" type="ORF">NCTC10207_01819</name>
        <name evidence="8" type="ORF">RA11412_2615</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004005325.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88914">
        <property type="protein sequence ID" value="BAV88914"/>
        <property type="gene ID" value="RA11412_2615"/>
    </dbReference>
    <dbReference type="GeneID" id="29743835"/>
    <dbReference type="KEGG" id="raj:RA11412_2615"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="6">
        <location>
            <begin position="59"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VEI23950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="125" mass="12946" checksum="9E5080AA24898FC7" modified="2018-10-10" version="1">MAKLSIEELIAAFKELSLVEVSEFVKAFEEEFDVTAAAPVAVVAGGAGGGDAAEEKSEFDVILESAGDKKIAVIKEVRALTSLGLKEAKDLVDGAPKPILEGASKEDAEKAKEQLEGAGATVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R323</accession>
    <name>A0A2Z5R323_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_2743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89042">
        <property type="protein sequence ID" value="BAV89042"/>
        <property type="gene ID" value="RA11412_2743"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2743"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
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        <location>
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        </location>
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        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="248"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV89042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="454" mass="49352" checksum="783F826B09E9983B" modified="2018-10-10" version="1">MLWDVGSSSFDTIMTTFIFTVYLTSAYFGSKEGTSAALSLGLTIAGFFIALLAPVTGQRADKTGKGIFWLGVNTLSLVTLTALCFFVAPSPAYLWLGVSLVSAASVFSEFAFVNYNAVLPRVSTPNNIGKISGLGWSAGYLGGVLALGVVLWGFVLEPNGLRLSTDDAFNIRAVALFSAFWCLVFCLPLLVRMRRRERFLPEVLPVRELKFLERGFTRLSPARQGGLFASYRELWRTIVRLQKSAPQTLYFLLASAVFRDGLTGIFTFGGILAAGTFGFTTSDVIIFGIAGNAVAAIGAVLGGYLDDYLGPKKIIVFSLVGILLAATPLLLFPYPGTFWVCALVLCLFVGPAQSASRTFLARIADPGTEGELFGLYSTTGRATSFLAPMLFGVFVVIFNAQVWGILGIMIVILAGLLMLLPLESPEALRQRKARRLEKKQVKRERKEHKAAHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R397</accession>
    <name>A0A2Z5R397_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative metallo-beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89001">
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        <property type="gene ID" value="RA11412_2702"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2702"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="53" mass="5614" checksum="72A0187286231890" modified="2018-10-10" version="1">MAQTIELADGVYRIATDNYRLNTGLILGLEAALVIDTGAGPVKAPKYMMKCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3D9</accession>
    <name>A0A2Z5R3D9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmG</name>
        <name evidence="6" type="ORF">I6I94_08190</name>
        <name evidence="5" type="ORF">RA11412_2792</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006889131.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89091">
        <property type="protein sequence ID" value="BAV89091"/>
        <property type="gene ID" value="RA11412_2792"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2792"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV89091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="57" mass="6761" checksum="636F963529D50180" modified="2018-10-10" version="1">MASKKAKDLRPIIKLKSTAGTGFTYVTRKNRRNNPDRMVLKKYDPVVRKHVDFREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3W2</accession>
    <name>A0A2Z5R3W2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88049">
        <property type="protein sequence ID" value="BAV88049"/>
        <property type="gene ID" value="RA11412_1750"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1750"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="105" mass="11679" checksum="0E352AB5BD1F0DEE" modified="2018-10-10" version="1">MPNLNEKLEWTDVDQRAVDTARILAADAVEKVGSGHPGTAMSLAPVAYLLFQKVMNQDPGDDRWQGRDRFILSPGHTSLTLYTQLFLGGYGLEMGDLESLRTWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4G2</accession>
    <name>A0A2Z5R4G2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1963 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_10590</name>
        <name evidence="1" type="ORF">RA11412_2220</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88519">
        <property type="protein sequence ID" value="BAV88519"/>
        <property type="gene ID" value="RA11412_2220"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2220"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015315">
        <property type="entry name" value="DUF1963"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035948">
        <property type="entry name" value="YwqG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09234">
        <property type="entry name" value="DUF1963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103032">
        <property type="entry name" value="SSF103032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="299" mass="33326" checksum="6A33C065F7B66FBE" modified="2018-10-10" version="1">MNTPVRILEQIRAVTQLVNAGAQKPALRITTNVPDAPLPVTASKFGGVPYLPAGVDAPLGSDGQPLGMIAQINCAELPENTLYPESGMLQFWIAPRPGWGADPTAPTSPLNNRVIYYPELTDPNPHAQSAHIDWEADKFPEYVWPIRRGTPELALKFAPALHNPLQYLREPFDELFTQYWNERYPAQPIDGYEDAISLGRATGGDGINIGEELGADDIINQLGGYPETFNDDPRQHPAFAKGYTFNLLTMGTEYELDPDVKWGYFGAANWLIAPEQLASRDFSDVYYEWNEHPAKLRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVB1</accession>
    <name>A0A2Z5QVB1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase III subunit delta'</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_08080</name>
        <name evidence="7" type="ORF">RA11412_0022</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86321">
        <property type="protein sequence ID" value="BAV86321"/>
        <property type="gene ID" value="RA11412_0022"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0022"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015199">
        <property type="entry name" value="DNA_pol_III_delta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09115">
        <property type="entry name" value="DNApol3-delta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNApol3-delta_C" evidence="6">
        <location>
            <begin position="307"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="225"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV86321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="379" mass="41664" checksum="C8A10851B6E86F19" modified="2018-10-10" version="1">MSLWDALLAPEPVTAQLRQDASSQAPTHAWLFTGGAGSLNRQAASVFAATLLCDQPDPADRGCGTCRGCVTVMNGSHADFTHFRTEAVSISIDEARELVLKAQDRPSVSRWRVILLEDTERMPERTSNVLLKAIEEPPPHTIWLLTAPSPADVLVTIRSRCRPVQLPVPQTQRIAAYLESTGVEAGLAHRAAALSLGDAEVAHRLATVPQALTRREDLARLPLRIRTLSSAMEAAERLISLAEQDAADATQQRDAAERAELLAMLGIAEGERVAPTLRAQVRRLEEQQKRRARRIQTDTLIRAVADIQTVLRDALTLQLGAQAPLLNEYLREPLQEYAARTSPAQTLSDVQAVETTLRRLRTNANARLALEALMSRFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVF2</accession>
    <name>A0A2Z5QVF2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-ACP thioesterase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_07905</name>
        <name evidence="3" type="ORF">NCTC10207_02033</name>
        <name evidence="1" type="ORF">RA11412_0063</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023134514.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86362">
        <property type="protein sequence ID" value="BAV86362"/>
        <property type="gene ID" value="RA11412_0063"/>
    </dbReference>
    <dbReference type="GeneID" id="32323288"/>
    <dbReference type="KEGG" id="raj:RA11412_0063"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI24339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="175" mass="19133" checksum="E4C9303903C410EC" modified="2018-10-10" version="1">MSEENTNKTTTDHTDREITVYVPPRWGDMDAYGHVNNVAILSIMEEARIALFGPPPSSGQKPKNLPAPPIPLFETMADGVQALIAEHGIRYVAPLPYTGENIPVRVRIEKITAASVRVGYKILNPVNGTDCVRAFTVLAFWDSTAEQLARLNPSQRAMLEGHKMLGHGSATAITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVP9</accession>
    <name>A0A2Z5QVP9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Plasmid stability-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Type II toxin-antitoxin system VapC family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_07495</name>
        <name evidence="5" type="ORF">RA11412_0178</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86477">
        <property type="protein sequence ID" value="BAV86477"/>
        <property type="gene ID" value="RA11412_0178"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0178"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="4">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV86477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="141" mass="16122" checksum="D8C0272395CD69FF" modified="2018-10-10" version="1">MYLADANVISELRKYRSGRIHPSVRHWVEHVDVNDVYISVISMMKIRTGILRHARKDAAQAQILQQWFSHELAPEFAGRILPVSLEVALTCAELHVLHKKSEYDALIGATAREHHLMLVTRNVADFQGMGLDILNPFEFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVU1</accession>
    <name>A0A2Z5QVU1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1963 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_07285</name>
        <name evidence="1" type="ORF">RA11412_0226</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="178" mass="18323" checksum="EC3D5E95E083BE31" modified="2018-10-10" version="1">MTIDSGQTLGSSGLMPVDDTPSGSTGQGSSGSPISNSNTDPEGTGTGGGSGGGPGSEELQPDPDETHPDDFILDPGNEKQDPGGGGGGDDKQHHDPNQRNFDDQESNKGGGGVTTSLLNARTLRWNIRNSRSRTTANNKTAPRLLNASNSNSRLIREQGNKKITLSPSLMPSLNGING</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWB7</accession>
    <name>A0A2Z5QWB7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86705">
        <property type="protein sequence ID" value="BAV86705"/>
        <property type="gene ID" value="RA11412_0406"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0406"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="290" mass="32740" checksum="8CB57A80F3F4250B" modified="2018-10-10" version="1">MENSFTLDRQTLRDMRDVLDAIRREHGGSINASMTLQGISDSQVEMHLTDTDYIDTRVNFEVSFEAMHFAVMCVPAENFAEDLGPYMMRSSSQFTFTWEDYGYGPEINGIPLSVGHAGGLDDMQDCTEWYFPETRWIPLGTITGDDYLRIVAQDAPAKTYKEGTLQYGVVHFLDVYFTVKDVFSFLENTLGLTLPADSHIIQDALKAEWKFPVTIFETVFVLADTTKAKNIQVSVSAPAPKELVLKFEGENFTHGTRAVSISEADEEEGYRPMFDFLTEINNVFSDPHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWB9</accession>
    <name>A0A2Z5QWB9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86692">
        <property type="protein sequence ID" value="BAV86692"/>
        <property type="gene ID" value="RA11412_0393"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0393"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="53" mass="5466" checksum="3AC13DAA693FD84B" modified="2018-10-10" version="1">MGRVLAEADASTVAPAGVRGRDGSQPAKGVFLVLCFPFGVFPAPASTIKRAFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWD3</accession>
    <name>A0A2Z5QWD3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_0403</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86702">
        <property type="protein sequence ID" value="BAV86702"/>
        <property type="gene ID" value="RA11412_0403"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0403"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="264"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="444" mass="49515" checksum="DC43CEE7232D31B9" modified="2018-10-10" version="1">MRSLSTFSGGQTVTAALTALLLSNPEFILLDEPTNNLDSAAKNRLFAALETLACPALIISHDRDLLAHMKAIAELHADREGRAHLRIYEGNYDTYRAARKAEESAVHRRVSEAKHEARKAERERIENQIKLDRNARRGRDFERSKRKPGLAMGLDKNSSERSAGKLRAAHESMVADARAAVSEAQENLRVQERIYLELAQDALPAGRKVLELQRVRKDSCASTQQSAELKNANTQNTVSHETQPYEVDYPSRDQDFPEALILTGPEHLRITGANGSGKTVLLNAIAHANDPGYRSPVPPVYRVLYRLGNAAYLPQRITLDPERTLLETVQRANPGASEQHLRDQLARLLFKRERVHQHIGELSGGERFRAALATVLLTDPVPQLLLLDEPTNNLDISSVDWLVQALDAYTGALIVVSHDEDFCERIRIDRTLSLSAKTLREGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWE0</accession>
    <name>A0A2Z5QWE0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class E sortase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Sortase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Sortase (Surface protein transpeptidase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_06340</name>
        <name evidence="5" type="ORF">NCTC10207_02387</name>
        <name evidence="3" type="ORF">RA11412_0436</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI25045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037233982.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86735">
        <property type="protein sequence ID" value="BAV86735"/>
        <property type="gene ID" value="RA11412_0436"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0436"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI25045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="248" mass="27324" checksum="4334B151BC29F007" modified="2018-10-10" version="1">MSHTPTKAHAPGKTRLQWTVQILGELLITAGFILLLFVAWQLWWTNIAADRSQAQAVDSLVKEFGESRTVTDWDPKNPPEPLAEPAHGQAFGVVYIPRFGEDYQRPAAQGSSNDVIDALGLGHYEGSAMPGGVGNFSLAGHRQTRGKVLNDIDLLQNGDHIYVRTKDGYYTYTVYEQKIVQPHEVDVIEPVPGHPGQSPTERIMTLTTCHPRYGDTERYIVHAKFESWQPASAGAPAEIAKVANNNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWI2</accession>
    <name>A0A2Z5QWI2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <accession>A0A2Z5QWJ6</accession>
    <name>A0A2Z5QWJ6_9MICC</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="39" mass="4231" checksum="77D25695A35309A0" modified="2018-10-10" version="1">MFKGFSGAPAADFLHGGSTQKSRYIQYSQFTPFSGRVSA</sequence>
</entry>
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    <name>A0A2Z5QWR3_9MICC</name>
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        <name type="scientific">Rothia aeria</name>
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            <taxon>Actinobacteria</taxon>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
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        <property type="gene ID" value="RA11412_0474"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="144" mass="16167" checksum="2F40CA5E1BD417E4" modified="2018-10-10" version="1">MEELLDIADIDGDIDIEVRNQRTYLAVLNDEDNNEELRQLVGRNGQVLEALQELVRLSVLAASGNRSRLILDVAGYRAERREQLADAARQAVEEVRESGEDYHMNPLGAYERKIVHDIVAEQGLYSESEGEGPSRHVVISLPEV</sequence>
</entry>
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    <accession>A0A2Z5QWR4</accession>
    <name>A0A2Z5QWR4_9MICC</name>
    <protein>
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            <fullName evidence="2">Arginine/ornithine antiporter ArcD</fullName>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="raj:RA11412_0576"/>
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    </dbReference>
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            <end position="27"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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</entry>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="176" mass="18931" checksum="0FFA96F5E0B2FEDF" modified="2018-10-10" version="1">MTEVAYRTVDTTELFKQAFGHHPAGVAVITATDENGEPAGFTASSVTSIAAEPPIVAFSLKADSGSAGKIAAADSFLIHLLDAENVQIARNFATHGYPRFADTSAWEFIATGEPLVHDIRRVLRATPLSRVEAGPALVFTAQVEEFVRHDLTGTPLVYHSREFHALGEHSTVNYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX54</accession>
    <name>A0A2Z5QX54_9MICC</name>
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        <submittedName>
            <fullName evidence="3">Phospholipid-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Putative kinase inhibitor protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">YbhB/YbcL family Raf kinase inhibitor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybcL</name>
        <name evidence="4" type="ORF">I6I94_05665</name>
        <name evidence="5" type="ORF">NCTC10207_00100</name>
        <name evidence="3" type="ORF">RA11412_0607</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888648.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86906">
        <property type="protein sequence ID" value="BAV86906"/>
        <property type="gene ID" value="RA11412_0607"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0607"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI22034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="182" mass="19268" checksum="B3E44863BD75B918" modified="2018-10-10" version="1">MPDYTPTSHAPLPRDPYEGLTKLPEFTLTSTDITDGGTAPTTMLSALFGVPGGQDLSPQLSWSGFPADTQSFVITCYDPDAPTPSGFWHWTVSNIPAAVTSLEAGAAAPHGALTHRNDAGVPGFLGAAPPAGHGPHRYIFCVTAVDVPELEVDENTSPAVVNFKLFFHGIARAFLTVTYEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX87</accession>
    <name>A0A2Z5QX87_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87048">
        <property type="protein sequence ID" value="BAV87048"/>
        <property type="gene ID" value="RA11412_0749"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0749"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016421223" evidence="2">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="88" mass="9744" checksum="42B4220F8F65BEBE" modified="2018-10-10" version="1">MLIKLVLCIMITCSVFKSEPSKFTADWGAWRNYQNSVALTQQVQAYAPQQPTAPGFSAPAAAAPNHYEAYSQQNSRHESDKNEGPKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXA8</accession>
    <name>A0A2Z5QXA8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86966">
        <property type="protein sequence ID" value="BAV86966"/>
        <property type="gene ID" value="RA11412_0667"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0667"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="49" mass="5421" checksum="4BBF9189B28A5D28" modified="2018-10-10" version="1">MRAPHPQSVYTLPHEQTVLNTLRKYGVVKAHLFGSAARGELTPASDLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXC4</accession>
    <name>A0A2Z5QXC4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86986">
        <property type="protein sequence ID" value="BAV86986"/>
        <property type="gene ID" value="RA11412_0687"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0687"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="134" mass="14889" checksum="EC95210BF8AC2653" modified="2018-10-10" version="1">MLTEQERANLSDYLDKLIARMHEDLPDLEADRQEWEKAARERMGDDAFEAWAAQAQERGGFGALAGFGPLGGFGPGFGPQGFGPRGFGGPGVGRGRKRRRHGGPKSRGERGEFPKGFEGKHHRHPSPWASWMMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXH3</accession>
    <name>A0A2Z5QXH3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_05055</name>
        <name evidence="3" type="ORF">RA11412_0744</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87043">
        <property type="protein sequence ID" value="BAV87043"/>
        <property type="gene ID" value="RA11412_0744"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0744"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="226" mass="24895" checksum="5268CA0B02E406EF" modified="2018-10-10" version="1">MPNTQPAQQPVNPSGGGLERVYALLPAQRPAPLIPVYLAAALIACQVVMWQVLACNILFTVQYPINALSESQAKAMEQIQQYYPALVTGLGIMFITGMHMFLLLKYLQGHRWAALVLTVLELLGMLCALSMVLIVGVLMSQLNGASSEQVDYLLGSSSPLYLPVYAGMPYLVMSVIALALLWSRASRAYTDARSAWRLRHRLRELEEQCDLLMQAQAAQAEIAKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXK2</accession>
    <name>A0A2Z5QXK2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87178">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="55" mass="5760" checksum="0A656BA17BEEC522" modified="2018-10-10" version="1">MSRVRVGAAALLLSERENYVSEAREPDAVASSGDYYTMLESAPEVDPASGVSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXN1</accession>
    <name>A0A2Z5QXN1_9MICC</name>
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        </submittedName>
        <submittedName>
            <fullName evidence="3">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_04945</name>
        <name evidence="2" type="ORF">RA11412_0771</name>
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    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87070">
        <property type="protein sequence ID" value="BAV87070"/>
        <property type="gene ID" value="RA11412_0771"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0771"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="230" mass="23759" checksum="E58BAA2DEC4B3C0C" modified="2018-10-10" version="1">MAVVTIIGGHGKVALLAEPLLVERGHTVNALIRRPEQSEDIVTRGANPVVTDITALSTEEMVKLLTELGTEVLVWSAGAGGVGGPERTYAVDRDAAIRSMDAARLAGIKRYVMVSYLGAGSGHGIDPDNSFYAYAESKAIADEHLRGSGLDYTILGPGMLTLEEAGGITLGVEPAHTPGAESNTPRATVAQVLAAVLEDPSTVGKALPFIGGPTPIAQALASAPNSNKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXT5</accession>
    <name>A0A2Z5QXT5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87252">
        <property type="protein sequence ID" value="BAV87252"/>
        <property type="gene ID" value="RA11412_0953"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0953"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="523" mass="58219" checksum="726F4B22C5B01D99" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXU1</accession>
    <name>A0A2Z5QXU1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">RA11412_0882</name>
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    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87181">
        <property type="protein sequence ID" value="BAV87181"/>
        <property type="gene ID" value="RA11412_0882"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0882"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="177"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="221" mass="23707" checksum="DD65B6FC9B0A52C2" modified="2018-10-10" version="1">MKRQIGLDYPVAVLSSRRAGASREVDALPVNGVWGDIDTNTFDTNVAVIPVAASSLGLARQGSEPLQYRVLTSLPLLGQTVSETDWVSFNPYTPNLWFDGGQGTGPSLFVDSPDAPVTAHLRSGTSAKMLLLHLHNPSTSAAQNTSQVASARVQRAQVLEARSGSAGPSNPAPAPPASHRFRDVGPAHPFYTEIEWLAAERITRGWPDGTYRPGRILSVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXW9</accession>
    <name>A0A2Z5QXW9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclease PIN</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">NCTC10207_00465</name>
        <name evidence="1" type="ORF">RA11412_1006</name>
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    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT89780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87305">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI22390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="73" mass="8030" checksum="F963378975B9127B" modified="2018-10-10" version="1">MYNSSAASNHLTPTRTYQEKLRAAAVPARGGYTAVSIQDYTRISSQRDEFLNFLLLPNPEGIPAVEYAGLRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXZ5</accession>
    <name>A0A2Z5QXZ5_9MICC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87213">
        <property type="protein sequence ID" value="BAV87213"/>
        <property type="gene ID" value="RA11412_0914"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0914"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="40" mass="4210" checksum="A0805F340DED3040" modified="2018-10-10" version="1">MRRRPGVPPLAGAPGAVCDFLLYPVGIARLGSRNTSVKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY55</accession>
    <name>A0A2Z5QY55_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase components of ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_1098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
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</entry>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87467">
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="168" mass="19060" checksum="D1B76974AAD700C6" modified="2018-10-10" version="1">MMWTSGHGEGWALYAERLMDELGFLQDPGDRMGMLDAQRMRAARVVFDIGVHCELPVPDEWAPRLGVEPGTVWTPELGYEFLVQNLEGSEGTIRFEFIRYLGWPGQAPSYKVGERIWLQLRQAALAQGDTLREFHTRALMLGSVGLDTLRRALSDEVMADDEEDDEDD</sequence>
</entry>
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    <accession>A0A2Z5QYD3</accession>
    <name>A0A2Z5QYD3_9MICC</name>
    <protein>
        <submittedName>
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        </submittedName>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
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    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87301">
        <property type="protein sequence ID" value="BAV87301"/>
        <property type="gene ID" value="RA11412_1002"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1002"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="16"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="275" mass="29857" checksum="023A5502A3A9518A" modified="2018-10-10" version="1">MVKNITFNDGNSIPQLGYGVWQIEDNGAADAVGTALETGYRHIDTASIYGNEVGVGRGIVTSSVPREDIFLTTKLWNSDQGFEKAIAALDASLERLGTDYVDLYLIHWAMPQQGTYLESWRALIELKKQGKVRSIGVSNFPQAQLREIIADTGVTPAIHQIELHPYFSQEELRKVHEELGIVTEAWSPLGQGGEILKDPVIVEIAGKHGISPAQAVLAWHLAKGIVAIPKSVTPARIAENFTAANVTLDAADIAAIDGLTRKDGRIGPDPQNPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYG1</accession>
    <name>A0A2Z5QYG1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87321">
        <property type="protein sequence ID" value="BAV87321"/>
        <property type="gene ID" value="RA11412_1022"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1022"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="273" mass="29455" checksum="BDF1386487FE20CD" modified="2018-10-10" version="1">MPHGDHSHYYTTTPTLSSLSLAADHTGHVITDNGKSAAFADGTGTFEVYSPSDLTVNKRTASELKTQQVKLPAPHHGFAIPLPDGHYLVSVGDEKTRTGAAVVDAQGKTITENKECPGVHGEAIAKDGVITVGCTDGALIYRDGTFTKVNNPENPYSRSGNQAGSADSQYVLADYKTDKEAKLERPEKFAIIDTVAKKRTVYSLPQGVSYTFRSLGRGPQGEALLLTTDGKLRILTRPPALNSGRYSSWMPGANLKRGRIRARPCGWMVRPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYG9</accession>
    <name>A0A2Z5QYG9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87515">
        <property type="protein sequence ID" value="BAV87515"/>
        <property type="gene ID" value="RA11412_1216"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1216"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="53"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="180" mass="19094" checksum="7B5B774FBC207D42" modified="2018-10-10" version="1">MFTPPIIVSAAEPTQAITVQQVSASRSKWRSPASGKVRVLKPFSKPAQRWSAGHRGVDLATDSDNAQVQAPAAGTVVFSGKVVDRTVIVLEHPGGLRSSFEPVKDPLPEGTQVSAGQTIATLDPDIHHCEQGPCLHWGVRRGGDKEDGSGKNAEYINPLTLLGRERPSILLPVDGSFTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYR8</accession>
    <name>A0A2Z5QYR8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidyl-tRNA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87431">
        <property type="protein sequence ID" value="BAV87431"/>
        <property type="gene ID" value="RA11412_1132"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1132"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="64" mass="7083" checksum="3606255850BFE2F0" modified="2018-10-10" version="1">MSDAWLIVGLGNPGPQYAKTRHNIGQMVLDELAREVGGTFKNILKHPLSWLRAVLVWAGPRLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYT7</accession>
    <name>A0A2Z5QYT7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome (Plasmid) partitioning protein ParA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">ParA family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Sporulation initiation inhibitor protein soj</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">soj_1</name>
        <name evidence="4" type="ORF">I6I94_02720</name>
        <name evidence="5" type="ORF">NCTC10207_00735</name>
        <name evidence="3" type="ORF">RA11412_1336</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887854.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87635">
        <property type="protein sequence ID" value="BAV87635"/>
        <property type="gene ID" value="RA11412_1336"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1336"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="32"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI22651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="286" mass="30939" checksum="FFD42B5D84B560EE" modified="2018-10-10" version="1">MTEAPEQELGPTGRPLREYPDPAPIQQHGPARIISMVNQKGGVGKTTSTINLGAALAECGRKVLLVDFDPQGALSAGFGANPHELDLTVYNVMMDRKVDIKDVIQGTGVENVDLLPANIDLSAAEVLLVNEVAREQVLASALRKVRDEYDVILIDCQPSLGLLTVNALTASDGVIIPLICEFFALRAVALLNDSIQKVQDRLNPDLDIVGVLATMFDARTTHSKEVLARIIDAFGDKVFDTVIKRTVKFPDATVSFEPILNYATNHPGAQAYRQVARELIYKGGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYU1</accession>
    <name>A0A2Z5QYU1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03635</name>
        <name evidence="2" type="ORF">RA11412_1105</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87404">
        <property type="protein sequence ID" value="BAV87404"/>
        <property type="gene ID" value="RA11412_1105"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1105"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="306" mass="33995" checksum="478A7D38D00EDCAD" modified="2018-10-10" version="1">MSRTMKVSAVIPHYGDPAPTLTLIEALRAQQGIAPDELEIIVSDDQSPVPFPDTKGVRVVRRETNGGFGSAVNSGVAVATGKWLFILNSDLSITDTFVADMLSHIEHRTPALASPQVVGHDGKQQWVARKFPTTAHIAWEWFTPLARFKPSGWWHRGVGHDVAACTSQNTVETDWVIGAAMVVPRDIYNRVGGMDERFYMNSEEVDFQRRLAEAGVPRLLVPQVRVEHEGGGSSPSARRRQWLTTARFTYADKWGDKATLGRTLKATSYANFLVNTVRAARNKEVNAQRTLREELAYVKRGENGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYV9</accession>
    <name>A0A2Z5QYV9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4345 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_03110</name>
        <name evidence="3" type="ORF">RA11412_1244</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87543">
        <property type="protein sequence ID" value="BAV87543"/>
        <property type="gene ID" value="RA11412_1244"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1244"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025597">
        <property type="entry name" value="DUF4345"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14248">
        <property type="entry name" value="DUF4345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="220" mass="23748" checksum="70013B99BB28BB0C" modified="2018-10-10" version="1">MNDKTSKNEAASQGDREESAGFPASEAGTAGRPEKEPQALKPARTTPENGETVKQPAPKKPEQKTKLEQKPQTLEDAAKPQNRGLFRSVVGLYGVAIIAYAAWQVVAGTQAAPDSAAVAVNPSIESNYAFLAAVYAGVGIAFLFIAWKFKWANMLVLACLVVFLGGVGRIISWASHGTPHWSLIVLMVTDLVIPPCLLVWYAWINKSNTIRQQMLSASRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYW4</accession>
    <name>A0A2Z5QYW4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87642">
        <property type="protein sequence ID" value="BAV87642"/>
        <property type="gene ID" value="RA11412_1343"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1343"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="4779" checksum="AFD64754F664B968" modified="2018-10-10" version="1">MNVEDLRLEHSTGADVGMAELSVSPAKHDELVTGLTERGWKVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYX6</accession>
    <name>A0A2Z5QYX6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-terminal domain of CinA type S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87566">
        <property type="protein sequence ID" value="BAV87566"/>
        <property type="gene ID" value="RA11412_1267"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1267"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="15"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="168" mass="16736" checksum="6A57B0A9C964739F" modified="2018-10-10" version="1">MGEGIRMVGPTEVEEAARSLHDALAGTGRTVATAESLTGGDVGGAICTIAGASEYYLGGVISYASAVKAAVLGVDRGLLERCGSVDAEVAVQMAAGTARVCGADYGVSTTGVAGPEPHDGKPVGTVFIGVFGPAGSAAHERHYTGDRAQIRAQATYDAILLLQAVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ13</accession>
    <name>A0A2Z5QZ13_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">rpmI</name>
        <name evidence="8" type="ORF">I6I94_02875</name>
        <name evidence="9" type="ORF">NCTC10207_00703</name>
        <name evidence="7" type="ORF">RA11412_1297</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87596.1"/>
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        <property type="nucleotide sequence ID" value="NZ_JQHE01000004.1"/>
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        <property type="protein sequence ID" value="BAV87596"/>
        <property type="gene ID" value="RA11412_1297"/>
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    <dbReference type="GeneID" id="29744019"/>
    <dbReference type="GeneID" id="61435876"/>
    <dbReference type="KEGG" id="raj:RA11412_1297"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
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        <property type="component" value="Chromosome 1"/>
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        <location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89576.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VEI22622.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="64" mass="7272" checksum="166D4348293BA9AE" modified="2018-10-10" version="1">MPKQKTHSGAKKRFKLTGSGKVKRQQANRRHYLEHKSSRLTRRLASDQIVTGGQAKVVKKMLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ41</accession>
    <name>A0A2Z5QZ41_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_02380</name>
        <name evidence="3" type="ORF">RA11412_1423</name>
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        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
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    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87722.1"/>
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    </dbReference>
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        <property type="gene ID" value="RA11412_1423"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="325" mass="34899" checksum="5186CC3063C22159" modified="2018-10-10" version="1">MSSLLNRVIAHYSSHRNPQDAPLTCTRAGAGSVCRSRWSQRITQIALAVALGLGGSGAPLFLPSPAAPAAHAESVFEHRFDPSHPIVDKADVLSQQQVQEASQKLTNIHSKRPFRFYIVFVKTAVPDASPTEVPSAPSSASPNAAPKPAGQTPEDKKRMLWAYQFTQKNHLDAYDALLVVETDTHQASLYHSPHGPLQNDEAQKLYSEHPADGVPSIESTVHEGKWDATLTSLEAALQKDGLYDRIIAARPSPHAFGPAYNPGFGEGPGAGGKWSPNPSAEAAQRSSSQDSPNSAVILAVLGAVAAAGVIGYVWMRRRRRNKPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ50</accession>
    <name>A0A2Z5QZ50_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-dependent RNA helicase HrpA</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="7">ATP-dependent helicase hrpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hrpA</name>
        <name evidence="8" type="ORF">I6I94_02330</name>
        <name evidence="7" type="ORF">RA11412_1433</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87732">
        <property type="protein sequence ID" value="BAV87732"/>
        <property type="gene ID" value="RA11412_1433"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1433"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010222">
        <property type="entry name" value="RNA_helicase_HrpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01967">
        <property type="entry name" value="DEAH_box_HrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="124"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="349"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1148"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1148"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="1479" mass="165280" checksum="B2EE6EE191CCEB0E" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZH1</accession>
    <name>A0A2Z5QZH1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87670">
        <property type="protein sequence ID" value="BAV87670"/>
        <property type="gene ID" value="RA11412_1371"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1371"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="60" mass="6266" checksum="324F681D0F5BC401" modified="2018-10-10" version="1">MAQQSSRGQNAKGTASAADAADSTLSHPMDQPLEGFGSLFPTTPPPRGEQGCFSQTLCPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZX2</accession>
    <name>A0A2Z5QZX2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitric-oxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87997">
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    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1698"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="210" mass="23449" checksum="91592DF44AA12ECF" modified="2018-10-10" version="1">MVNHYRDTLTKDNTSQGLFPNAIKSEEELHDLVAFFGWTAWASAAERPNQDYTYTNNWPAEANVDNKPTADLMVWSALSLIALVGGTGLMFAIYGRWSRTIGWHGEEAPVLDFRQPDEVRLTPRRRRPGCSSLLFWCCSCYKLLWVLLPSTTVWSSQASSGLIWGSLSPTPSPEHGTCSSPSSGLLRRSWQAVSLSPRSLPAKSRRNRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZX5</accession>
    <name>A0A2Z5QZX5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_1542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87841">
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    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1542"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016454390" evidence="4">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="23"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="263" mass="28471" checksum="D9A9C791A2F5C3D2" modified="2018-10-10" version="1">MRVSSATIEGMSTTTIAAAAPAVATRNLFKTYGRGEATVHALNNVTIDFERGKFTAIMGPSGSGKSTLMQTLATLDTPDRNPETSIQIGGTELYGQKDNQLTEFRREHVGFIFQAFNLVPTLTAGQNIDLPLGLAGKKPDPVWRDYLVKTLGLAERLNHRPEQLSGGQQQRVAIVRALLSRPEVVFADEPTGNLDSNSGTEVLKLLRDAATEQKQTILMVTHDAHAASYADRVVFLKDGMIAGEMLNPTHDAVLQAMGQLEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZY5</accession>
    <name>A0A2Z5QZY5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87851">
        <property type="protein sequence ID" value="BAV87851"/>
        <property type="gene ID" value="RA11412_1552"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1552"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
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    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="38"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="276" mass="29698" checksum="80DDA112968CDB84" modified="2018-10-10" version="1">MRTQNHTVRVRATDTSGSTEGDPMHKLAIITAVAPDRADHLHETAQSVAQTRNHLNIQWIVVWDGVSTQPVEHADAQLTTGKLCSGASVARNTALPTVEAEYLLKLDADDVLNPEGVAATIHQLEKNPDAGWAAANMLIHGTGERTEHWANTPETYPEGALAGLWTVPFPLHPGAVIYRTDRVLQAAGWPALNSAENLGLLLHVAEDTQGLRVPDVLVYHRQWDAQESQQEYAPNAKSKPSKPSAPPLTPAADAPAANPCTSAPAKPHRSRRQPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R068</accession>
    <name>A0A2Z5R068_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ComEC/Rec2-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_1856</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88155">
        <property type="protein sequence ID" value="BAV88155"/>
        <property type="gene ID" value="RA11412_1856"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1856"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="8">
        <location>
            <begin position="173"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="481"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="518" mass="53832" checksum="D614506878784D72" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R082</accession>
    <name>A0A2Z5R082_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3,4-dihydroxy-2-butanone-4-phosphate synthase</fullName>
            <ecNumber evidence="3">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ribB</name>
        <name evidence="10" type="ORF">I6I94_01630</name>
        <name evidence="9" type="ORF">RA11412_1631</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87930">
        <property type="protein sequence ID" value="BAV87930"/>
        <property type="gene ID" value="RA11412_1631"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1631"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="7">
        <location>
            <begin position="107"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="8">
        <location>
            <begin position="107"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="428" mass="44528" checksum="BD7FCDE36CE371BD" modified="2018-10-10" version="1">MFTGIIGALGTVESVTPVLDAQGRDTGAAHITINAGDIVADLGHGGSLAVNGVCLTAIDLPHLSEGQFRAYAMGETLARTNLGALVPGSHVNLERCMPAGGRFDGHVVQGHVDGTATVVSVTDHDAWRTVRFAVPAEFAPYLVQKGSITVSGVSLTVTAVSDPAQKQHWFEVGLIPETLAATNLGELTVGDTVNLETDALAKYVGRLLAFDTPQAREHTTANGPGRTLDTVQSAVDAIAAGGAVVVVDDESRENEGDIIFAAEHATKQLMGFTVRYTSGVICAPMSASRADKLNLPPMLAHNEDPKGTAYTVSCDARMGVSTGISAADRARTVRVLADPSATPTDITRPGHIFPLRAVAGGVAQRPGHTEAAVELCRAAGLSGVGVIAELVHDDGSMMRFDALRAFATEHSLPMVSIEDLIAYLKEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0B5</accession>
    <name>A0A2Z5R0B5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00690</name>
        <name evidence="2" type="ORF">RA11412_1859</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88158">
        <property type="protein sequence ID" value="BAV88158"/>
        <property type="gene ID" value="RA11412_1859"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1859"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="315" mass="33091" checksum="E010746ADD4BFFEF" modified="2018-10-10" version="1">MGRIAIVTDSAAAIAPENLKERQKRGGFAVVPMPVAIQEATVRAGIRGPRTETNTRDVTGLGPEEMDEAILMAHVLGNTVNTSGPAPGVFADTYDALVDEGYEHILSIHLSGELSGTVEAARVGAQLSKARVTVLDSRTIAGAYGHAALHAHKVADTCDTPEELAEIVTSICAATDIYFYIPTLDALRRGGRVSPALAMVGQMFQIKPIGTVADGKLTYVERPRTATRAKERLTQIIREACAKHRSVKKPPADAAAKHGVRPTGHVVALHHMGNLAEAKTLQDSLGAYALDAALSPLPPVLAAHSGPGALAAIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0D4</accession>
    <name>A0A2Z5R0D4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate regulon transcriptional regulatory protein PhoB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_0010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86309">
        <property type="protein sequence ID" value="BAV86309"/>
        <property type="gene ID" value="RA11412_0010"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0010"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="129"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="216" mass="23773" checksum="E1CE413E00FCBCC0" modified="2018-10-10" version="1">MKILIVEDEEALSDPLAYLLGREGFTPVVVDNGLQAVPTFEREGADLVLLDVMLPGQSGLEVCKQLRAVSSVPIIMLTAKDTELDKVLGLELGADDYVTKPYSSRELIARIRAVLRRRSGGDPEEDESRAPLVAGPVRMDVQRHVVTVDGGEVSMPLKEFELLEILLRNAGRVMTRASLIEQVWGADYVGDTKTLDVHIKRLRSKIEPQASSPGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0E5</accession>
    <name>A0A2Z5R0E5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87944">
        <property type="protein sequence ID" value="BAV87944"/>
        <property type="gene ID" value="RA11412_1645"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1645"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="5050" checksum="DA3D06253B417BCF" modified="2018-10-10" version="1">MYDYEKEEIAKEGGDIDDLISIIIIDLHDIHPSLPMQFEEFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0J3</accession>
    <name>A0A2Z5R0J3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88153">
        <property type="protein sequence ID" value="BAV88153"/>
        <property type="gene ID" value="RA11412_1854"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1854"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_gamma3" evidence="1">
        <location>
            <begin position="13"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="133" mass="14382" checksum="6FA0756804209FEE" modified="2018-10-10" version="1">MNRYYSGRTEVTAFRVADAAIAGNAPEAMRLLRHSLSTGTEPIPMLGALAMRVRNISRAHGARASSTELAQQLGMAPWQAEQAIRDARRFSPAQLAHIVRMLAEADAQLKGEGQDPVYAIERAVLSIAMPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0P6</accession>
    <name>A0A2Z5R0P6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88056">
        <property type="protein sequence ID" value="BAV88056"/>
        <property type="gene ID" value="RA11412_1757"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1757"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="151"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="269" mass="30662" checksum="F21F29D9F6369BAC" modified="2018-10-10" version="1">MTEKVEREANDTVISEILEMNPELEGIGNYEYGWADSDVAGQAAKRGLDEAVVRDISMKKNEPEWMLNMRLKALKFFERKPMPTWGADLSEIDFDNIKYFVRSTEGQAESWEELPEDIRITYERLGIPEAERNSLVAGVAAQYESEVVYHQIREDLEAQGVIFVDTDTGLRDYPELFKEYFGSIIPIGDNKFSALNTAVWSGGSFVYVPRGCTWKSRCRRISVLILRTWASLSAPSLSRMRGPMCITLRAAPPPSTSLTRCTRRSLRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0P8</accession>
    <name>A0A2Z5R0P8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongation factor 4</fullName>
            <shortName evidence="4">EF-4</shortName>
            <ecNumber evidence="4">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lepA</name>
        <name evidence="7" type="ORF">RA11412_1953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88252">
        <property type="protein sequence ID" value="BAV88252"/>
        <property type="gene ID" value="RA11412_1953"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1953"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFG_C" evidence="6">
        <location>
            <begin position="173"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="389" mass="43345" checksum="8E19458C99E228B1" modified="2018-10-10" version="1">MMSTGAEHDLLEIGVISPEPIPSKGLSVGEVGYLITGVKDVRQSRVGDTVTSAHKPAEESLGGYEDPKPMVFSGLFPIDGSDYPALRDALDKLKLNDAALIYEPETSAALGFGFRCGFLGLLHLEIVRERLEREFNLDLISTAPNVIYDVVDEAGNAKRVTNPSEFPEGKVATIREPMVACTIIAPSDYIGAIMELCQSRRGQMGGMDYLSEDRVEMRYRLPLAEIVFDFFDQLKSRTRGYASLDWKFDGEEEADLVKVDILLQGEKVDAFSAITHRDKAYSYGVMMTGKLRELIPRQQFEVPIQAAIGSRIIARENIRAMRKDVLSKCYGGDISRKRKLLEKQKEGKKRMKMVGRVEVPQEAFIAALSSGEEKEKKDKKSSRYSVENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0R6</accession>
    <name>A0A2Z5R0R6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cobA</name>
        <name evidence="9" type="ORF">I6I94_00005</name>
        <name evidence="8" type="ORF">RA11412_2029</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88328">
        <property type="protein sequence ID" value="BAV88328"/>
        <property type="gene ID" value="RA11412_2029"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2029"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="44"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="297" mass="31186" checksum="2FB8B61A316302BA" modified="2018-10-10" version="1">MSPKIPPFPPREFATIDEVLAGSSIGSADREVPSPGPRAETPGKVYIAGGGPGALDLLTLRAARALGEADVVLLDHLAPQEFAKYSPNALIVDVGKVPGKHAVPQSRIQQLMIDYALAGKTVVRLKGGDPYVYGRGAEELDACIAAEVDAEVIPGITSAVAVPARAAIPVTLRKVSSIFTVVSGHSGLNEDEVNTLVATLRANGTVVLLMGVRTLPDTVAALTAHGISADTPMATIENGYSDAERVTITTLENSERDCAEVKAPAITVIGEVVYYARDDQQQFVSEVHEKLRAQSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0S6</accession>
    <name>A0A2Z5R0S6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA recombination repair protein RecO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88096">
        <property type="protein sequence ID" value="BAV88096"/>
        <property type="gene ID" value="RA11412_1797"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1797"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="117" mass="12622" checksum="A34FBC2982E88297" modified="2018-10-10" version="1">MQLAGWPLTTNTCIHCGTPTPTSYHTPHGTLCPTCAHTATTPLTPLNTQETTYLNALTTGHWDTIDKTPTHTTQKSSTSSSTPPNTTSKPPSKPSPTSKPKHHNPTRYNNPKKPPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0V3</accession>
    <name>A0A2Z5R0V3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichyl-phosphate beta-D-mannosyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Polyprenol monophosphomannose synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase</fullName>
            <ecNumber evidence="4">2.7.8.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">arnC</name>
        <name evidence="3" type="ORF">I6I94_00790</name>
        <name evidence="4" type="ORF">NCTC10207_01149</name>
        <name evidence="2" type="ORF">RA11412_1827</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.30" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023133068.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88126">
        <property type="protein sequence ID" value="BAV88126"/>
        <property type="gene ID" value="RA11412_1827"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1827"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI23052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="244" mass="27033" checksum="E6E994E6AB881C3C" modified="2018-10-10" version="1">MRVLTVIPTYNEKENLPVVVERLRKAAPEVDILVVDDNSPDGTGQIADDMAAKDPQIHVLHRTVKDGLGGAYLAGFDWGLAEGYEILIEMDADCSHQPEQLPSLVRAVEAGADLAIGSRYVPGGKTKNWPIHRQILSRGANLYTRTILGTKVKDITAGFRAYRRDALQRLNLDGIDSKGYVFQVDLAWRSEQAGLKIVEVPITFVEREIGASKMTGNIIFDSMRKVTSWGLTNRVNTLKKKFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0V5</accession>
    <name>A0A2Z5R0V5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88415">
        <property type="protein sequence ID" value="BAV88415"/>
        <property type="gene ID" value="RA11412_2116"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2116"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="81" mass="9342" checksum="B713C37DFF52B99B" modified="2018-10-10" version="1">MLITPQPTQEGSQYRWPLRIVNDLGSFAVKDGKYTELSPQDQHYDKEVVGLVNYQQGRWEFRWEGDEDDDPSPSASPRASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0X6</accession>
    <name>A0A2Z5R0X6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pup ligase PafA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88141">
        <property type="protein sequence ID" value="BAV88141"/>
        <property type="gene ID" value="RA11412_1842"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1842"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="149" mass="16465" checksum="CA06646E396FE18D" modified="2018-10-10" version="1">MQQRIVGIETEFGLSYVPKGLGRLSNEEAAAALFKPVLDEWRSTNVFLPNGGRLYLDVGSHPEYASAECASIEELLAQERAGELLLARLARQAQQRLRTEGAHGTPLEGSFYLLKNNVDSAGNSYGSHENYLISRKLAFPTLIEQLVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R118</accession>
    <name>A0A2Z5R118_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88437">
        <property type="protein sequence ID" value="BAV88437"/>
        <property type="gene ID" value="RA11412_2138"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2138"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="123"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="346" mass="36841" checksum="BD7F571A60FAB517" modified="2018-10-10" version="1">MLTLGVPTPGTDELPGAPAPVARIHNVSAGPVADMTVTLRGMPGRGNPIYLELDANPNLYTMEQVQAHARHMGAWLENWATAATNELPLETITTALPAELETINAFNSTGHHIEYKTLLQRFTDAVAAHPNEPALIATAPGERYTLTPESPHAHEFNLTLTYAQLDARARALAASLVAAGVRPGTAVGLRFNRGIEQYIALYAALYAGAIYVPILPELPAERVGHMLTDAGCSALLNGPGLGLLAPAELSPENPERFTNLPQLPFTALTPTAQHPLPADAAPASAILPGHETELDDTAYILFTSGSTGRPKGVAVSHRAIDNRLRWQQSKSRSPPVTGYSTKPHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R133</accession>
    <name>A0A2Z5R133_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88495">
        <property type="protein sequence ID" value="BAV88495"/>
        <property type="gene ID" value="RA11412_2196"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2196"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="46" mass="4863" checksum="C2AF4C6A699B3E96" modified="2018-10-10" version="1">MTSSPAASSKPLYRERLAPGVGTWLLVLVTGGASYLVGRRSVSLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1C9</accession>
    <name>A0A2Z5R1C9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_2017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88316">
        <property type="protein sequence ID" value="BAV88316"/>
        <property type="gene ID" value="RA11412_2017"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2017"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="198"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="231"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="443" mass="47887" checksum="3DB2C540291E5869" modified="2018-10-10" version="1">MPVIRNTLTALTLLVGVSIWNPVLGLTLGIALAVIVALTLVSNKLEKKSHDMKSGSEQELAGRIVEYASCQSALRSAGRSTEYEPLLSAVRECERRNRVSQWVAMAGLAIGGMSAQLTVVAVITVTVQLSLSGSLDPVATVVFIGIALRFMRNLQDTVNFLVSTESSRVPLRDVHEILNTELLPVPSSSAELTNPGEVSVQNATFSYVPGTPVVHDVSFTAPPRTMTAIVGPSGSGKTTLFKLIARFWDVDSGTVRVGGTDVREQTTEQLMGQLSMVFQDVYLYDDTLIENIRVGREGATNDEVLQAAQLAGCSEIAERLPQSWETRVGEGGGRLSGGERQRVSIARALLKNAPILLFDEATSALDPENEAGVQRSIRELRKHATVLVIAHKLDTVRDADQIIVLDEHGGISQVGTHDELVSVEGLYHRFWQARVDAAGWSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1G1</accession>
    <name>A0A2Z5R1G1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsI</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pbpA</name>
        <name evidence="3" type="ORF">I6I94_06365</name>
        <name evidence="4" type="ORF">NCTC10207_02382</name>
        <name evidence="2" type="ORF">RA11412_0430</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI25035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037233967.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86729">
        <property type="protein sequence ID" value="BAV86729"/>
        <property type="gene ID" value="RA11412_0430"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0430"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transpeptidase" evidence="1">
        <location>
            <begin position="155"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI25035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="480" mass="51617" checksum="F9DD950D3C1A222C" modified="2018-10-10" version="1">MDRAIRRMWMSAACVFILLMGTLSYIQFFDAQMLMEHKWNTRALYDNYGSQRGSIVVNGTEIASSVKSNDEYNYQRVYSEPEKYAGITGYFSSVYGSTGIESALDKELSGTSDSQFYDRVAQLFSGNSTRGASVELTVDDKLQTLAYQLLQGRKGSIVAMNPKTGEILAMASSPSYDPNKLAAHSEQSVIADYTKLTQDQQSPLFNRAIAGNTYSPGSTFKIIDAVAALESGKYDEKSVIDNPAQLPLPGTNVTLPNFVNGQCATRTQATIEWALAQSCNTPFANIALDLGQEKISQTASKFGYGQDLSIPLKVTKSDFPSDMTKSQLAQASVGQYDVKTTPLQVAMTSAAIANGGVQMKPNLVRSVKTSNLSTLSEFSPEKLRTSTSQKVADQVKQWMVNSVDNGIASGAGVSGVKVAGKTGTAEIGTTGLNNSWFTGFAPADDPKIAIAVVYEDIDVSTGAKLSTNAGKQLFEAVLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1K3</accession>
    <name>A0A2Z5R1K3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="12" type="ORF">I6I94_11045</name>
        <name evidence="11" type="ORF">RA11412_2097</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88396">
        <property type="protein sequence ID" value="BAV88396"/>
        <property type="gene ID" value="RA11412_2097"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2097"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="149"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV88396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT89021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="370" mass="40195" checksum="E3E81EA8A09AF7BF" modified="2018-10-10" version="1">MTDKITVALLCGGRSSEHSISLITAVGVLGAIDTAKYEVVPVGITKDGRWYLTDAQELEKLTAGSDMAEFTGSAQQVFLPLGAGDSRLHLVDSAGHLEFGPAINVVFPLLHGPFGEDGTVQGLLEMANLPYVGCGVTASAVGMDKHFMKVAFADAGLEVGPYEVVTDRQWRHDRDGALERVARLGYPMFVKPARAGSSFGITKVDTAEQLVPAIEQARVYDPKVVIEAGIVGREIECGILDGHNGDMPRASYPGEIEMQGEQGGFYDFEAKYVSKTTAVTRCPANLPPEDLERMRQLAVKAFLALDGEGISRADFFYTPDARLIVNEVNTMPGFTPISMYKTMWEKTGIEYKDLIDELLMLALERPVGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1K6</accession>
    <name>A0A2Z5R1K6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dak phosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_11070</name>
        <name evidence="2" type="ORF">RA11412_2092</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88391">
        <property type="protein sequence ID" value="BAV88391"/>
        <property type="gene ID" value="RA11412_2092"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2092"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="12"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="380" mass="41800" checksum="90F80A833316952E" modified="2018-10-10" version="1">MLGDNAPKTEFTFGIGWVDAACAQARKYRDGLNSLNAFPVPDKDTGSNLTVTLTALKEAFDAEYEVLQKEPKPADAAALNLRIGQLYERAIMQAYRSARGNSGTLLCTWALEAVRSYWGLPGHLTEDMDESEVAQIPVFSALHQQYEEAPAAEIRESSYREAFALSAAAQRVRQSVPDASLMRSTMGAVMLAVADYRFHYRPGSELQDMLNRSEYRRTSVLRALEGTAEYPPAPELKGTVDAGALGFYLTVVHTNSRWRTSRLDDAQIERMLVPPAMPSRHLQERRGDSTAASARVPEWELMGTVDADPVAVAQIRSELEQLGDSLLLTPLDVSAGMWSLHVHVFSLDDARAAIARHGMLREERVSSLREGPADSACAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1L6</accession>
    <name>A0A2Z5R1L6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flp pilus assembly protein TadB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_2279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88578">
        <property type="protein sequence ID" value="BAV88578"/>
        <property type="gene ID" value="RA11412_2279"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2279"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="74"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="246" mass="27254" checksum="035A13ED636B5321" modified="2018-10-10" version="1">MLRKAGMHSLSLRTFMWLSVGSAAITALVIFAVTSLPNLALLSSVAGFYLPRIVVSRRAQAREAKVWEQWPDAVDHLRSAIRAGLSLPEALVQLSYRGPEELRDAFARFGSDYRASGEFIPSLNRLKEYLADPVADTIIESLKIAREVGGSDLGRLLGTLSDFLRESSRTRAELQARQSWTVNGAKLACVAPWVVLMLMATQPAVRTVYNSWAGFILMLSGVVLSWIAYRLMLRIGTLPSEKRVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1M2</accession>
    <name>A0A2Z5R1M2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88404">
        <property type="protein sequence ID" value="BAV88404"/>
        <property type="gene ID" value="RA11412_2105"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2105"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="72"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="242" mass="25507" checksum="E0555438FFB29F68" modified="2018-10-10" version="1">MVEVEPVSSSGVGVLDKATLILDCLEAGPVTLGQLVNATGLARPTAHRLAVALTHHRLVARDVQGRFMLGPRLSELASATAEDQLLAAAAPVLDKLRHATNESAQIYRRQGDWRVCVASAERPVGMRETIPVGTQLSMKAGSAAQVLLAWEDQGRIIEGLRNAHFSAAMLASVRRIGWAQSVGERERGTASVSAPVYSPTGKVIAAVSIAGSIDRMSRQPGRMYAEAVLEAAAALTAALRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Q4</accession>
    <name>A0A2Z5R1Q4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding response regulator mtrA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Phosphate regulon transcriptional regulatory protein PhoB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Response regulator transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mtrA</name>
        <name evidence="7" type="ORF">I6I94_10225</name>
        <name evidence="8" type="ORF">NCTC10207_01555</name>
        <name evidence="6" type="ORF">RA11412_2304</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006889219.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88603">
        <property type="protein sequence ID" value="BAV88603"/>
        <property type="gene ID" value="RA11412_2304"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2304"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI23450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="251" mass="27376" checksum="2CFAD39FB402D58E" modified="2018-10-10" version="1">MTVSTPTILVVDDDDALAEMIGIVLAQEGYNAQFCENGARAFEVFMRYSPDLVLLDLMLPGKNGIEVCEQIRASSNVPIIMLTAKSDTEDVVKGLEAGADDYIAKPFKHIELLARIRTRLRPRESRQLVVRIGDTVMDMDGRTVTYNGTEIPMTPLEFDLLAALVRRPGQALSRQELLEIVWGYSDVSDSLVNVHVQRLRAKFSELGAQQVIQTVRGVGYKVPLDSVGSVSTTSSLPTVPAAGSPQAGSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1R9</accession>
    <name>A0A2Z5R1R9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="10">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-IPM isomerase</fullName>
            <shortName evidence="10">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">leuD</name>
        <name evidence="13" type="ORF">I6I94_11020</name>
        <name evidence="12" type="ORF">RA11412_2102</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88401">
        <property type="protein sequence ID" value="BAV88401"/>
        <property type="gene ID" value="RA11412_2102"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2102"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="11">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV88401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT89016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="195" mass="21817" checksum="DB42015E427D7E1A" modified="2018-10-10" version="1">MEPIIEHTGIGVPLRTSNVDTDQILPAVYLKRVTKTGFDDALFANWRKDPEFILNTEPYRHGSVLVVGPDFGTGSSREHAVWALKDYGFRVVISARFGDIFRGNAGKQGLVTAQVAQDDIELIWKAIEDEPGTEITVNLKEKTVAVGALTVPFQLDDYVCWRLMEGLDDIGLTLQNIEAIKAYEARRPAWMPRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1T0</accession>
    <name>A0A2Z5R1T0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Cysteine synthase</fullName>
            <ecNumber evidence="4 10">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysK</name>
        <name evidence="14" type="synonym">cysK1</name>
        <name evidence="13" type="ORF">I6I94_10945</name>
        <name evidence="14" type="ORF">NCTC10207_01387</name>
        <name evidence="12" type="ORF">RA11412_2122</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4 10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88421">
        <property type="protein sequence ID" value="BAV88421"/>
        <property type="gene ID" value="RA11412_2122"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2122"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="11">
        <location>
            <begin position="10"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="8">
        <location>
            <begin position="179"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV88421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT89001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VEI23287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="311" mass="32548" checksum="D958BC0ABF5A43EE" modified="2018-10-10" version="1">MAQIVNSIVDAIGQTPLVRLNRLSEGLPGNIAVKLEFYNPAGSVKDRIGRAIIDAAEEAGALKPGGTIVEGTSGNTGIALAMVGAARGYNVILTMPETMSAERRVLLRAYGAKIVLTPGTDGMKGAVEKAKEIVESTDNAVLASQFSNEANPAIHYKTTGPEIWDATDGKIDIFVSGIGTGGTISGAGKYLKEKNPNLKIVAVEPQDSPLLSEGRVGPHKIQGLGANFVPDTLNRDIYDAVIAVSGEDAIRTSRALATEEGILGGISSGAAVYAAVEEAKKSENKDKLIVAVVPDFGERYISTVLYEDIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1T1</accession>
    <name>A0A2Z5R1T1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86829">
        <property type="protein sequence ID" value="BAV86829"/>
        <property type="gene ID" value="RA11412_0530"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0530"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="53" mass="5767" checksum="D294295710FE7BE1" modified="2018-10-10" version="1">MQALSAKTKATLADSGAAKRRGVNICILFSTVNNNAPQHHFSEYAAVWVVQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1T7</accession>
    <name>A0A2Z5R1T7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88431">
        <property type="protein sequence ID" value="BAV88431"/>
        <property type="gene ID" value="RA11412_2132"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2132"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019292">
        <property type="entry name" value="McrC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10117">
        <property type="entry name" value="McrBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="307" mass="35203" checksum="2D78C5ECA0ECDE2E" modified="2018-10-10" version="1">MRTLAVHVLPKIWSPNGRRNIIEPLPADRPHPTHLLDETGCLHVYLYEREILKLPTDWQQPFSAVVGSGNEPAESNRREDTPYVDLWNAPAWEPHTRDADFTIGRVIRPGSDEEFTPVRQFWRILEHYHQAPVEDATSRTVPPQGLGIFSRIDWLQEPTYRKFLNLCKNALEHRRPRFESETDELGFVRGRMVLDKLIDRQATHRTGVVCEFDSLTTDIHLWQVIRAGLQRVAMQAKDAQLRQQALGYEATLRDVSVHNAQTLLNERLSPRSWRASPMSRRSPTGMRGQLLPSSSGSGSIPTRMRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1U7</accession>
    <name>A0A2Z5R1U7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_09780</name>
        <name evidence="1" type="ORF">RA11412_2416</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88715">
        <property type="protein sequence ID" value="BAV88715"/>
        <property type="gene ID" value="RA11412_2416"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2416"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="135" mass="14968" checksum="27CF0262F285BCAD" modified="2018-10-10" version="1">MSIFEKTSDDSTPASRAPVVTSCFLGIMGVLHFVKPEHFDRIVPRALPGSARFYTYASGVAELGVAGLLTAPTTRRAGALAAIALYTAVFPANVQMAWDWRHESAFKRVVAFGRLPLQLPMIRRAWRIYKTSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Z1</accession>
    <name>A0A2Z5R1Z1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86909">
        <property type="protein sequence ID" value="BAV86909"/>
        <property type="gene ID" value="RA11412_0610"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0610"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="54" mass="6310" checksum="315AE57B07EAA641" modified="2018-10-10" version="1">MVFLIITFGVDVLDRHMKIEYITVPIILIIMLIVFPKLFTIFKGNGTEDNQQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R227</accession>
    <name>A0A2Z5R227_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="1">4.2.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_10015</name>
        <name evidence="3" type="ORF">RA11412_2353</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydroxymethylbilane = H2O + uroporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:18965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="EC" id="4.2.1.75"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uroporphyrinogen-III synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88652">
        <property type="protein sequence ID" value="BAV88652"/>
        <property type="gene ID" value="RA11412_2353"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2353"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38042">
        <property type="entry name" value="PTHR38042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HEM4" evidence="2">
        <location>
            <begin position="35"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="276" mass="28605" checksum="EF9F1C17ECC16737" modified="2018-10-10" version="1">MGAARVLLTRTAAKGTGFARALSELARQRGEPAPNVLYAPVHVPRTVAYTPELSAALQATAADQVAWVTFTSANAVRACTELWGEHFAHVLNAADARLACVGKATAAELERCGIEPDYIPHTQSAMGMLAGFPASDRQQDEPDTVWVVEGQNARPTLREGLGALGFRVMRTVVYRMEPAAEADLAPGELGCDAAREALSRETSAGQPVTDAVVATAPSLLQALAEGVPTDRFPPVVAIGQSTASAARSLGVPYVVADSPSAQDLASAAFSVVSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R262</accession>
    <name>A0A2Z5R262_9MICC</name>
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        <submittedName>
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    </protein>
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        <name evidence="1" type="ORF">RA11412_2262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="1 2" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88561">
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    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2262"/>
    <dbReference type="Proteomes" id="UP000250241">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="122" mass="13697" checksum="1E860092CB044D2B" modified="2018-10-10" version="1">MIAPSTFDIDLGLTSARSRLNLANMVDMASQNNIRVLVVGPPPTLDAERNRRIADLSAAYADVVTRRNQVYVDTFNPLLHHEQWRNDLATNNGLPGQSGYGLIAWLVLHRGWYSWLSIPEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R284</accession>
    <name>A0A2Z5R284_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF488 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Probable uroporphyrin-III c-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_09825</name>
        <name evidence="1" type="ORF">RA11412_2403</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88702">
        <property type="protein sequence ID" value="BAV88702"/>
        <property type="gene ID" value="RA11412_2403"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2403"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="130" mass="15096" checksum="0A6B50E008F22DAA" modified="2018-10-10" version="1">MDITIKRIYEEVSPDDGYRVLVDRLWPRGVTKDRARLNKWAKELAPSTQARIEFGHNPERFEAFKHRYRAELDVNPDAQSLMRSVVANAKETGDMRITLLYAAKDEHCNHAMILCSYMAEHLPDLTRLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2M2</accession>
    <name>A0A2Z5R2M2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium-dependent transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_08625</name>
        <name evidence="8" type="ORF">RA11412_2679</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88978">
        <property type="protein sequence ID" value="BAV88978"/>
        <property type="gene ID" value="RA11412_2679"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2679"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="PTHR11616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="536" mass="57468" checksum="2A9812415BD250BC" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2M3</accession>
    <name>A0A2Z5R2M3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Maltose and glucose-specific IIC component protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="16">PTS transporter subunit EIIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I6I94_09475</name>
        <name evidence="15" type="ORF">RA11412_2485</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88784">
        <property type="protein sequence ID" value="BAV88784"/>
        <property type="gene ID" value="RA11412_2485"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2485"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <sequence length="543" mass="59507" checksum="700D89F7BAE7DEDE" modified="2018-10-10" version="1"> </sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <name>A0A2Z5R2V4_9MICC</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="QQT89838.1"/>
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        <property type="protein sequence ID" value="BAV87219"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="168" mass="18158" checksum="37F116D531B201CE" modified="2018-10-10" version="1">MSESVQAPVTVSPARIEKHGSLLVAGVSQVYKLGDDFTPLWDELNQKASPAMLDILAVTQYIGVCTQPSTDGFVRYTAGILVDDRASAHKLGLGLLELPASTYAVVEVTGPISRSIPAGFESFEREFFPSHPQYRPLGGLEVYGRGDMQAADYTMELWVPLLEVPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2X6</accession>
    <name>A0A2Z5R2X6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
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    </protein>
    <gene>
        <name evidence="15" type="ORF">I6I94_08660</name>
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    <organism evidence="14 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887753.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88972">
        <property type="protein sequence ID" value="BAV88972"/>
        <property type="gene ID" value="RA11412_2673"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2673"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="13">
        <location>
            <begin position="13"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV88972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QQT88590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="499" mass="55979" checksum="45F906FD28F70799" modified="2018-10-10" version="1">MTNNPIHPGSFTTTSTGTPVASDDHSLTIGADGPIVLHDAYAVEKLAQFNRERVPERVVHAKGTGAYGYFETTEDVSQYTRAALFQPGVKTELLIRFSTVAGESGSPDTWRDPRGFAVKFYTTEGNYDLVGNNTPIFFIRDAIKFPDFIHSQKRMPGSGLRDHDMQWDFWSLNPATAHQVTWLMGDRGLPRTLRHMDGFGSHTYQWINAEGERFWVKYHFKTEQGNEFFTQAQADEMAGKDADFHRRDLREAIERGDYPAWTLYVQIMPYEEAKTYRINPFDLTKVWPHSDYPLIKVGRMVLDRNPQNFFAEIEQAAFSPSNFVPGIAASPDKMLLGRIFSYPDAHRYRIGTNFAQLPVNAPHAAPVNNYSHDGSMRYNFNDPSVPTYAPNSLGGPHADAARAGEGNWESDGSLVRTAYTLRAEDDDFSQARTLYEVTMDDAQRERLVSNIAGHVGAVRSDEIRERAFTYWDNVHPELGSRVREAVAAAAAPSSCGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R308</accession>
    <name>A0A2Z5R308_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thymidylate synthase</fullName>
            <ecNumber evidence="1">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.45" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88940">
        <property type="protein sequence ID" value="BAV88940"/>
        <property type="gene ID" value="RA11412_2641"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2641"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="4">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="135" mass="15428" checksum="2E4F9BBECE54B60D" modified="2018-10-10" version="1">MSTPAHHASGQQSIPTPYEDLLREILDENRDAIAADAQRKDRTGTGTFGVFGRQMRFDLRNSFPLITTKRVHFKSVAVELLWFLRGSSNIRWLQERGVTIWDEWADENGDLGPVYGVQWRSWPTPTAAPSTRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R338</accession>
    <name>A0A2Z5R338_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nitrate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_2592</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88891">
        <property type="protein sequence ID" value="BAV88891"/>
        <property type="gene ID" value="RA11412_2592"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2592"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="297" mass="30863" checksum="03E6D5A268A71C50" modified="2018-10-10" version="1">MLVFSFLLGIAGTVFAVGIPFSAAWYPPARKGFATGVFGAGMVGTALSAFFTPRLLSLVGYMNTHYIIAGLCAVTATISFLFLRDSPATANREVTPLMPKIIRAFKVKSTWQLCFLYSVVFGGFVAFSNYLPTYLNNIYNFDAEAAGARAAGFAAAAVVARPFGGILADKFGPKIITFIALGGVSALALVTAFQPDAEHVYGPIFLAMAALLGLGSGSVFGWVGRAADPKNVGAVSGVIAAAGALGGFFPPLVMGATYDAAHRNYFVGLTLLAVTAALAFASAFLVKHGGKPEHHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R342</accession>
    <name>A0A2Z5R342_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_08600</name>
        <name evidence="5" type="ORF">RA11412_2685</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88984">
        <property type="protein sequence ID" value="BAV88984"/>
        <property type="gene ID" value="RA11412_2685"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2685"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="273" mass="29174" checksum="A3652EC5D9A658DC" modified="2018-10-10" version="1">MTETMKPAPASVSIKGLNKSYGKLQVLKGIDIEVEPGEVVCLIGPSGSGKSTLLRCVNLLEEPQGGTITVGHTEVTDPDVDINAVRTRMGMVFQQFNLFGHLSVLDNCTIAQVKVLGRSKATAEQVAREQLAKVGLAGKENSLPSQLSGGQQQRVAIARALSMNPELMLFDEPTSALDPEMVGDVLGIMRELADEGMTMLVVTHEMAFARDVADRVVFMADGVVVEEGPAEQVIGNPQHERTKTFLARVLDPTHVAQAQQDTAKDASTAQAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R349</accession>
    <name>A0A2Z5R349_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sucrose-specific IIB component protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_2612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88911">
        <property type="protein sequence ID" value="BAV88911"/>
        <property type="gene ID" value="RA11412_2612"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2612"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="5">
        <location>
            <begin position="133"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="276" mass="27820" checksum="FE5EB12DB4AF987A" modified="2018-10-10" version="1">MNLVLRWPFYIAIASAGIGGALSAILGVKASALGAAGYLGIPSVNPQAGAGWLGFIVCLLMTTALAFAASYVWGLKVARGEASSPDAAEPATAGETKAETAVAAPKTPEVEGEKAELAAHLSGTVVPLAEVSDQSFASGALGSGNAIEPTQGTLVAPADGKITVAFPTGHAYGMRTEDGLDLLMHIGFDTVELDGKHFTPKVAKGDVVKRGDVLAEFDIDAIKKAGYPVTTPLVVTNAKKAVALMADAAGAGTTVTAGKDTLADVTLKTKATTTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R396</accession>
    <name>A0A2Z5R396_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89084">
        <property type="protein sequence ID" value="BAV89084"/>
        <property type="gene ID" value="RA11412_2785"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2785"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="5440" checksum="D1527CEF4762BAE5" modified="2018-10-10" version="1">MRYQLPHWMRYRPESQPQKSWLLMKRLMSWSSKNYWKMMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3C1</accession>
    <name>A0A2Z5R3C1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellulose 1,4-beta-cellobiosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_08250</name>
        <name evidence="3" type="ORF">RA11412_2777</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89076">
        <property type="protein sequence ID" value="BAV89076"/>
        <property type="gene ID" value="RA11412_2777"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2777"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340118" evidence="2">
        <location>
            <begin position="36"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV89076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="221" mass="21647" checksum="47FCFD0C5AF155DA" modified="2018-10-10" version="1">MNTVFKNSKISVLTALSIAGLLTLSACGTTNTISEDSASATPGETSSASTTPKPTASGSKGAAAGKTTGSAGAETNPGTAGASTQANPHEKPKTSTSPSTAETSAGGGTQTAGSGQKPATSASSPAWKNTENGGATVTVGTAGSWTRTNPNGDTTTVKADGSWETRYANGDTAEVSVDGEYTVVKNGSPTTEKPATPQVPAVPSGQNVTPKAPAEPTQTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R451</accession>
    <name>A0A2Z5R451_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88299">
        <property type="protein sequence ID" value="BAV88299"/>
        <property type="gene ID" value="RA11412_2000"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2000"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4487" checksum="7274D4E0B33A06DD" modified="2018-10-10" version="1">MFSFYIFTCDVLARHYERAGTAVTVGGGLPVFKHTVRGGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4I6</accession>
    <name>A0A2Z5R4I6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88579">
        <property type="protein sequence ID" value="BAV88579"/>
        <property type="gene ID" value="RA11412_2280"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2280"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="97"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="429" mass="47283" checksum="CEDF576AE91C253E" modified="2018-10-10" version="1">MESSRATLPCDNRSASGTSYESYLLIAQHVREQIRARELDPYTSRDEVVSIIEASVADYDRRMLRASLPVLHDAADAIRYLTDDICGFGPLQRFLDDDSIEEIWINAPDEIFVARSGESELTGLRLDIDNINHLLERMLKPSGRRLDLSSPFVDASLPDGSRLHAVIPDVTRSHPSINIRKFIVRARRLPDLVKLGSMSAGAAGLLHAAVESGMNILVSGATQAGKTTMLNCLSASIPPRERVITCEEIFELQVPLRDVVGMQCRQANLEGTGSISLRRLVKEALRMRPDRIIIGEVREAESLDMLIALNAGLPGMCTIHANSARDAVTKICTLPLLAGENISSAFVVPTVASCFDLIVHCERDARGYRRVEEIYMLGGRVENGVIEMSPLFVRQEGRMVCTALELPHPERWARAGHAPERILAMAKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4J0</accession>
    <name>A0A2Z5R4J0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88589">
        <property type="protein sequence ID" value="BAV88589"/>
        <property type="gene ID" value="RA11412_2290"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2290"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="156" mass="17056" checksum="A9F53BCC6A0AF290" modified="2018-10-10" version="1">MNPKAPLSVLFVAGLSTVEAVYLLFRGVADPLFGDAARAVQERLVGGIIQAFFGLIILFFALRFYRGKRTARTPMALIHACASFINASNIYSYFSYRSVVGADHAPFSFIIIPTVLLLLSGTALVAVFLPATSQYLHETTEADEADLKRHSVTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4M6</accession>
    <name>A0A2Z5R4M6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I6I94_09930</name>
        <name evidence="11" type="ORF">RA11412_2380</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88679">
        <property type="protein sequence ID" value="BAV88679"/>
        <property type="gene ID" value="RA11412_2380"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2380"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:glycolipid mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="PTHR12468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV88679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT88829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="434" mass="48405" checksum="A8E880840F37F95B" modified="2018-10-10" version="1">MSTDSTILDRLYTRLHGWGHYLCTLFVELPVILRVLLIYGLSRLWGVAVFSMVGRQQLWGPWGERLGYLEFISTWDSGWYWQIADRGYPVELPQDMSGTVMQNQWAFYPLFPLTSGYISRTTGLEYYAVASTVALLAGFIAAWIVYRLCIASLQALGRTDAAENTSLGCWAVAVFAFLPVAPVLQAPYAESVNLIFLAWTLYLMVRARYLLLLPVAALACLSRPVGVPLGAAAGLWWFICLITDMRADARRRADGETPRGFWRIFASRAVQLCSALMVCACALIWPAIAWAVTGRVDAYTATETAWRSSHLAPFEPWLKQGSIYFGVFSIPLLVLLVVVFALVLLSPAVRGVLSGPLILWCACYAAYLLIFLNPQSSTFRLLLPLFPLVLPMVAVSASRAYRWLLVLSGATLQLVWVGWLWHWKQNPGGGDYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4R0</accession>
    <name>A0A2Z5R4R0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88759">
        <property type="protein sequence ID" value="BAV88759"/>
        <property type="gene ID" value="RA11412_2460"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2460"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="225" mass="24276" checksum="ECF3C7A1A6DA4946" modified="2018-10-10" version="1">MNRLLVHNRDSVQKTLTEAAEKISTTGEYKKLWRQVTTDTHAHLISDENTPAALDISAFYRELDTAVGTFGIYDPDIPSWGNRYITLEDGSSTAVHGKIMQLKSFADSADTFLTVSLMSMLIALLLWPRGRPLFLACVLIAATLAAWGASFYLEGVTPASLGMNPGSELGKVFLDGLFNGARPDAVASARATASYSLIATLITLLLGILVKLTRLTASTTTVPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4Y5</accession>
    <name>A0A2Z5R4Y5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Octaprenyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88979">
        <property type="protein sequence ID" value="BAV88979"/>
        <property type="gene ID" value="RA11412_2680"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2680"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="355" mass="37608" checksum="1344DEC0B9B49122" modified="2018-10-10" version="1">MSASNTEQPIAATEFMAADDFTLPAGFELIAADPELGPRILTSLARIEERLGEAIAQTDKLADVASRHLLLAGGKRVRPLLTLLAAAVDGQINDEVTEAAVVVELTHLATLYHDDVMDEAPKRRGVDTAQTIWGNSVAILTGDLIFSRASLLVSELGTRPMKIQAQTFERLVLGQLYETTGPREHQDILDHYIAVIEGKTGSLIAAAGEYGSLLSGASEETVQIMARYGELVGVAFQLADDVIDIVSDGASSGKTRGTDLREGVPTLPTILLDRAAAAGDESAREVRALIDTDLSTDEALGAAVSALAAHPVTEQAWRIAYEWADRAIAALAPLPESTAKAALTSFAHAVVHREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4Y7</accession>
    <name>A0A2Z5R4Y7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88989">
        <property type="protein sequence ID" value="BAV88989"/>
        <property type="gene ID" value="RA11412_2690"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2690"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="102" mass="11087" checksum="5AB85133F0B2C392" modified="2018-10-10" version="1">MTAFWTVIGLMVLRYFRRSEFRGGKRTIGSVIVPLLTIATLFLGFCSVVLYLIVSVSSLPGGVFVASTSMVLAVGTGCAAALIGLLRPRNRPRPAYTKVWSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVG3</accession>
    <name>A0A2Z5QVG3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86371">
        <property type="protein sequence ID" value="BAV86371"/>
        <property type="gene ID" value="RA11412_0072"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0072"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="106" mass="11675" checksum="1C1F218ACA9E48BD" modified="2018-10-10" version="1">MSAQNSSTQTPTQETHKESDIHARFFPILARVASVTAVLMYVFYFPQIIGNINGHKGDWIQPLVAGINCTLWVAYGLWREKKDWPIVIANAPGIIFGGTAAVTALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVJ0</accession>
    <name>A0A2Z5QVJ0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07770</name>
        <name evidence="2" type="ORF">RA11412_0101</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86400">
        <property type="protein sequence ID" value="BAV86400"/>
        <property type="gene ID" value="RA11412_0101"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0101"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="199" mass="20948" checksum="01591E50A4449546" modified="2018-10-10" version="1">MNEKSERSGSHPHVNSLAARTPAVIQVAALYAAYPMALVSAAWITVGRALFGAAGDLVPIFAISFGPALALILCLAARWAFTDARRAVAAAELTRPACRWGVAIAQSTCWVLAFLFGMFIPDYRAGVPVSGMGALVGGEYVGYAAGFGNTFGILTFAAAITAAALAYSANRRGARLQQGVTDEVLEEQARQQSPYDFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVJ2</accession>
    <name>A0A2Z5QVJ2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86324">
        <property type="protein sequence ID" value="BAV86324"/>
        <property type="gene ID" value="RA11412_0025"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0025"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007841">
        <property type="entry name" value="UPF0210"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37560">
        <property type="entry name" value="PTHR37560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05167">
        <property type="entry name" value="DUF711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="155" mass="15553" checksum="861DAFAD989E4FF9" modified="2018-10-10" version="1">MGTHGTVAALALLNDAVKKGGLMACSHVGGLSGSFIPISEDIGMIESAAAGHITLDKLEAMTAICSVGLDMVAVPGDTPAATLAAMIADEAAIGVMNHKTTAVRVIPAVGLGVGDTVEFGGLLGRAPIMPVHTPSSEAFIARCGRIPSPVHGFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVP1</accession>
    <name>A0A2Z5QVP1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">60 kDa chaperonin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RA11412_0151</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86450">
        <property type="protein sequence ID" value="BAV86450"/>
        <property type="gene ID" value="RA11412_0151"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0151"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV86450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="448" mass="47885" checksum="C7F2BDA621EE41CA" modified="2018-10-10" version="1">MAKLIAFDEEARRGLERGLNTLADAVKVTLGPRGRNVVLEKSWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDIAGDGTTTATVLAQALVREGLRNVAAGADPLSLKRGIEKAVEEVTKTLLDSAKEVETEEEIAATASISAGDQEIGKLIAQAMEKVGKEGVITVEESNTFGLHLELTEGMRFDKGFLSGYFVTDPERQEAVLEDPYILVVNQKISNVKDLVPVLEKVMQSGKPLLIIAEDVEGEALALLVLNKMRGSIKSVAVKAPGFGDRRKAMMADIAILTGGQVITEEVGLALDTATLDMLGKARKVVVTKDETTIIEGAGDAAALDGRVAQIRAEIANSDSDYDREKLQERLAKLAGGVAVLKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVPGGGVALIQAGAKVFDKLDLKGMRQPARTSCVWLSMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVQ1</accession>
    <name>A0A2Z5QVQ1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="5 13">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ptsP</name>
        <name evidence="21" type="ORF">I6I94_07545</name>
        <name evidence="20" type="ORF">RA11412_0163</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 23">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5 13"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86462">
        <property type="protein sequence ID" value="BAV86462"/>
        <property type="gene ID" value="RA11412_0163"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0163"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="13 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="19">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="17">
        <location>
            <begin position="152"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="18">
        <location>
            <begin position="253"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="15">
        <location>
            <begin position="435"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="14">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00033235"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="BAV86462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QQT88388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="564" mass="59781" checksum="639688C888F8F5EC" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVQ4</accession>
    <name>A0A2Z5QVQ4_9MICC</name>
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        </submittedName>
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        </submittedName>
        <submittedName>
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            <ecNumber evidence="4">2.7.11.-</ecNumber>
        </submittedName>
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    <gene>
        <name evidence="4" type="primary">ptsH</name>
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        <name evidence="4" type="ORF">NCTC10207_02112</name>
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        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86461">
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        <property type="gene ID" value="RA11412_0162"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0162"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HPr-like"/>
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        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="BAV86461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI24500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="92" mass="9478" checksum="45248B24114AB7F8" modified="2018-10-10" version="1">MAEREATIASRVGLHARPAAIFAEAAGDLPVEVTIAAKGEPADEAMDAASILSLMSLGAKHGDVVVLRAEGEGAEEALDTLVKILETDHDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVS5</accession>
    <name>A0A2Z5QVS5_9MICC</name>
    <protein>
        <submittedName>
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        <submittedName>
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        </submittedName>
        <submittedName>
            <fullName evidence="8">Methionine import system permease protein MetP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">metP</name>
        <name evidence="7" type="ORF">I6I94_07475</name>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887028.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86481">
        <property type="protein sequence ID" value="BAV86481"/>
        <property type="gene ID" value="RA11412_0182"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0182"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="31"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI24529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="235" mass="25221" checksum="E71A2FBC392565FB" modified="2018-10-10" version="1">MNALLTTAPLAASTRPVNWDTFIPKTLVPAIFDTLYMVAITMVIAGFLGLLLGALLYTTREGNIYQNRFVYAVLNVLVNIVRPIPFIILIAALGPLTSAVVQTRLGLNAAIFAMSFGASFAIARIVEQNMVSIDPGVVEAARAMGASRLRILFTVMIPEALGPLILGYTFIVIGVVDMSAMAGYVGGGGLGKVAIVDGYQKFQDQITWLVVAVIIILVQLVQFIGNTLAKRVLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVX5</accession>
    <name>A0A2Z5QVX5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86557">
        <property type="protein sequence ID" value="BAV86557"/>
        <property type="gene ID" value="RA11412_0258"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0258"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <property type="gene ID" value="RA11412_0247"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4642" checksum="A2B48D6374A6F8D3" modified="2018-10-10" version="1">MDNKEQNIFAVGLGVMSEDSLEKISSSLEEFLLVKKGMFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW01</accession>
    <name>A0A2Z5QW01_9MICC</name>
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            <fullName evidence="1">Pyridoxine biosynthesis glutamine amidotransferase</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
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    <reference evidence="1 2" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86587">
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLP_synth_Pdx2"/>
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    </dbReference>
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        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="121" mass="12643" checksum="B38EFB633E136888" modified="2018-10-10" version="1">MPTLGTCAGLIMLSTVIDDPAPGQQSLGVLDVSVGRNAFGSQVDSAQVHLPWLTPSGEEVVIDTAFIRAPIVTRAGEGVQVVAHHEGKIVGVRAGNIIGISFHPEVTGDTTVHEELLSLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
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    <name>A0A2Z5QW11_9MICC</name>
    <protein>
        <submittedName>
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        </submittedName>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">I6I94_07460</name>
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    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
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            <taxon>Bacteria</taxon>
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    <reference evidence="3 5" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86484">
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        <property type="gene ID" value="RA11412_0185"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0185"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="49"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="485"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="578" mass="63215" checksum="0D56B861E8BB8D6B" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW19</accession>
    <name>A0A2Z5QW19_9MICC</name>
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        <lineage>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">NCTC10207</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86580">
        <property type="protein sequence ID" value="BAV86580"/>
        <property type="gene ID" value="RA11412_0281"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0281"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VEI24750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <sequence length="42" mass="4620" checksum="1AAC909BFC904766" modified="2018-10-10" version="1">MSIYEIVETAQAILVSYILTDGSAQAVSYAVEAISVFLKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW57</accession>
    <name>A0A2Z5QW57_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CHAP domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Putative choline binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_06695</name>
        <name evidence="4" type="ORF">RA11412_0346</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86645">
        <property type="protein sequence ID" value="BAV86645"/>
        <property type="gene ID" value="RA11412_0346"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0346"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="3">
        <location>
            <begin position="283"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="433" mass="45761" checksum="4A4BC300512DA26F" modified="2018-10-10" version="1">MDEENNGSTGLIIAGVLVVVLAIIFAPVLVVIIIFGNNQAAQAACTPGKPSGETAVRGEPNSTPPPPGEKGPDGRPAPYYGVIPVDYDDKGETSGVGGLIPQEYEQDVIDASKVSGIPTSWIAAQIEAESRWNAGLGPNKANASGLTQFTAETWATYGHGASQSDGHASIRAMGEYLRDLKKQLEPTIQSSGQDWKDVVMAGYNAGPGGPMQYGGIPPYEETQTYVKRIHVLHDHFYKRVYGDEVGGKSDGSVDTAPVQNAPAGSGGSNSGSGCSGYSGGSTSGNDDYPWKGYAEGPNPITGAYYVNCTDFSLWRLNQQVGATDPQKPKYTNSNFVNGRVLGNGGDWADTWRAKGWPVDNTPEVGAMAHFYAGAPGASATYGHIAVVKEVKDDGKTVVIEEYNANTPHAYGTRQLPASNISNYLHIPDSEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW75</accession>
    <name>A0A2Z5QW75_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">M18 family aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I6I94_06890</name>
        <name evidence="11" type="ORF">RA11412_0294</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86593">
        <property type="protein sequence ID" value="BAV86593"/>
        <property type="gene ID" value="RA11412_0294"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0294"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV86593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT88271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="439" mass="47326" checksum="C82CAF41C1C17942" modified="2018-10-10" version="1">MSVDAVKNIEDLAQFVEDSPVSYLAARTVARRLQGAGFTELTESETWPDSAATGRHFVVRDGAIIAWAGGRQASAASGYRVLGAHTDSPALKVKPKSSLTVKGWHQIGVENYGGGLLNSYLDRELRLAGRLTVHEGGTLRDRYVCTPPLARIPQLAPHLDHKRNELVLDKQFNLYPIWGIDPGQNDVLAYLGRHTVDEGGDVDPATVVGYDLLTADSQPGRRFGQHGEFFASGRLDNLSSVHAGLCALERYVADNADEHASHTVMLAGFDHEEVGSETRSGAAGPFLEDVLVRLSAARGENTEQYRRSVASSVCLSADAGHLLHPNYQGHHDPVVQPVPGAGPLLKINANQRYATDSVGAGIFAAACKAARVPYQEFVSNNNMPCGSTIGPITATRLGMRTVDVGVGLLSMHSAREMCHVHDMAYLTRAVEGFYRLQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWM7</accession>
    <name>A0A2Z5QWM7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">dnaN</name>
        <name evidence="14" type="ORF">I6I94_06145</name>
        <name evidence="15" type="ORF">NCTC10207_00002</name>
        <name evidence="13" type="ORF">RA11412_0481</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="14 18" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI21941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887406.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86780">
        <property type="protein sequence ID" value="BAV86780"/>
        <property type="gene ID" value="RA11412_0481"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0481"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="127"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="246"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV86780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT88135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VEI21941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="375" mass="40453" checksum="B7B856CF4618AF2D" modified="2018-10-10" version="1">MKFTIDRDVLAEAVGWTARSLPARPTSPVLSGLLITAENGEVAIAGFDHEISARQVVEADIEQDGTCLVPGKMLADICRSLPSAPVEFAASDSKVFISCRSAKFQLAAMPLVDYPELPELPEVSGTVDGTEFARAVSQVLVAASKDETLPILTGIRLEVQGDTMTLLATDRYRLAMRELTWSPTNPEISAQVLIKSKTLAEVGRTLAGSGELSIALPDAHELIGFEAASRRTTSVLMDGDYPNIRALFPEETQIHAVIRTSDLAEAARRISLVAERNTPLRLAFSETGEVVIDAGRGDEAQGSETLQAHLSGQEVTVAYNPAYLSEGLGAFTTEFVRFSFTEPTRPAVLSGQDEILGDDSTEYRYLLMPVRLPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWU8</accession>
    <name>A0A2Z5QWU8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mannose-specific IID component protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">PTS mannose transporter subunit IID</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">PTS system mannose-specific EIID component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">manZ</name>
        <name evidence="11" type="ORF">I6I94_05970</name>
        <name evidence="12" type="ORF">NCTC10207_00032</name>
        <name evidence="10" type="ORF">RA11412_0514</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI21966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86813">
        <property type="protein sequence ID" value="BAV86813"/>
        <property type="gene ID" value="RA11412_0514"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0514"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004704">
        <property type="entry name" value="PTS_IID_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03613">
        <property type="entry name" value="EIID-AGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00828">
        <property type="entry name" value="EIID-AGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51108">
        <property type="entry name" value="PTS_EIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV86813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT88109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VEI21966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="288" mass="31480" checksum="0E6D84783B15A534" modified="2018-10-10" version="1">MTENTQEKVTTEVPDLTKGDKINTYIRSTFLLGSFNFERMQSIGFAVSMIPAIKRFYTKKEDQAEALTRHLEFFNTQPWVASPIIGVTAAMEREKAAGKEGIDDAAITNVKVGLMGPLAGVGDPIYWGTARIVLAAIGASFAISGNILGPLIFFFGMTAIRWATRWYGFQYGYEKGTQIVGDAGGNTLQKITQGASVMGLFVMGALVYRWTSINIPLKLTEYEQADGTHVDVTVQSILNQLLPGLAALGLCFLCMWLLRKRVNAIWIIFGLFAVGIAGAYLGFLALPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX42</accession>
    <name>A0A2Z5QX42_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hpt</name>
        <name evidence="5" type="ORF">I6I94_05255</name>
        <name evidence="4" type="ORF">RA11412_0699</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888433.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86998">
        <property type="protein sequence ID" value="BAV86998"/>
        <property type="gene ID" value="RA11412_0699"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0699"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="17"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="183" mass="20225" checksum="093B258477E28144" modified="2018-10-10" version="1">MQAQDVQDDLKNVLFTKEEINAKVAELAARIDEDYEGKDVLLVGVLKGAIMVMADLSRALKGHYTMDWMAVSSYGSGTKSSGVVRILKDLDTDLTGRNVLIVEDIIDSGLTLAWLQQNLMSRGAASVEICALLRKPKAVKTDVEVKYVGWDIDPEFVVGYGLDFAEKYRNLDCVATLHPHVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX96</accession>
    <name>A0A2Z5QX96_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-acetylhomoserine sulfhydrylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87058">
        <property type="protein sequence ID" value="BAV87058"/>
        <property type="gene ID" value="RA11412_0759"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0759"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="191" mass="20185" checksum="20A6B9C870013D39" modified="2018-10-10" version="1">MAEHTFGFRTRALHAGGTPDAEHGARAVPIYQTTSFVFKDTDDAANLFSLQKYGNVYSRLSNPTVAALEERIASLEGGIGAVATASGMAAEFITFAALCQAGDHIVASSQLYGGTVTQLDVSLRRFGIETTFVEGTDPADYKAALTENTKAIYTEVVANPSGEIADLEGLAAVAHEAGVPSLWMPRSQPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXK6</accession>
    <name>A0A2Z5QXK6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87172">
        <property type="protein sequence ID" value="BAV87172"/>
        <property type="gene ID" value="RA11412_0873"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0873"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="169" mass="17415" checksum="E96B803A99DC903B" modified="2018-10-10" version="1">MAIDPSVVARFPLVLLLVVAGILLARGLPVFVAERFTDTGSELRSTSEKIELALYSAAGLPIIVAVTTIATGSGLLEDATASLLVAGGAFTVLLFPLWAAAIKRAFRRQGASADQQPSQKEQIAALKARKTAQVRLTTGMLPVVPPAQEAKSTAPKDGSPGAAQQPSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXL3</accession>
    <name>A0A2Z5QXL3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87083">
        <property type="protein sequence ID" value="BAV87083"/>
        <property type="gene ID" value="RA11412_0784"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0784"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="3843" checksum="9794444EACA5DDE9" modified="2018-10-10" version="1">MVLALAGTAPAAIKTTVAAKRRADFMNATVAPRMLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXR9</accession>
    <name>A0A2Z5QXR9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-proline glycine betaine binding ABC transporter protein ProX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87110">
        <property type="protein sequence ID" value="BAV87110"/>
        <property type="gene ID" value="RA11412_0811"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0811"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="70"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="335" mass="35598" checksum="C59B18EC5995E369" modified="2018-10-10" version="1">MNLVHRRNTNDRSFLSGKSAKSSGTAETGMARGVTRRRALGVVGALGTLGALSACGLSGENVFGGEHDGIIVGSAAFAESQILAEIYSQALNKNGFKSSTQLGIGAREAYLGALTSGAIDVIPEYSGNLLLYLDENSTAQTKQEILQALGRVLQDNLKALDASQAENKDTLVVTQQTAQKYNLRTLDDMAKVCTELKIGAAPEFAERAYGIPGLKDKYGCVPAEFVSLADGGGALTVKALQDNTVQVVDLYSTTPAITQNNFVMLEDPKNMIPAQQVLPIINTKRVPEDAHAVLNRISAVLTTDDLRSLNDEVSGDKKLDPSTAATNWLKDKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXS8</accession>
    <name>A0A2Z5QXS8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87171">
        <property type="protein sequence ID" value="BAV87171"/>
        <property type="gene ID" value="RA11412_0872"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0872"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="323" mass="36059" checksum="F2AE6649F27B2A06" modified="2018-10-10" version="1">MQRLTHNISTGADILEQDFTQAMLRLNQGDQATHQTLINALEEIKRTADAAGRYAPYFARARTTLKDAGKPPHILENIKVSWSYRESDTKRPSGKPEVVWWSPTVHLPKVREEHTPEEKYLLTLHYAVMSCEQLALTCPSSTAPVAVGLLEQWVFFDEEDHYMHNMARLLRSHPGTWDSLSAQALAVLANSKHQVDRAGAAELLADTLGDRLSYQDAIAGFAQAAPALMFTRWAHTFEDMAALTPRITLRFLDGLLPHCERTQHGMGKLLGVYTQEYLRVHGAKHSANKSPQLSPEMIAWLNGFKGSSQAAKHARTILKAADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXX9</accession>
    <name>A0A2Z5QXX9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding transcriptional repressor MngR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">GntR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Predicted transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mngR</name>
        <name evidence="4" type="ORF">I6I94_03975</name>
        <name evidence="5" type="ORF">NCTC10207_00474</name>
        <name evidence="3" type="ORF">RA11412_1016</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023133773.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87315">
        <property type="protein sequence ID" value="BAV87315"/>
        <property type="gene ID" value="RA11412_1016"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1016"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI22399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="289" mass="31572" checksum="D957DED9ED644F08" modified="2018-10-10" version="1">MIPINPSGSSFDANETLGAGRDPHDSETTHPVDEAEHPVHPDEAGLLAQALPPVPGPKYEQVIRLLEQRYIIPGSPGDKLPTERALQLQFGVSRQTVRNALKYLLDKGLIYNQQGSGTYVADHSQASFIPRICSYAEDMSRRGMESSTRMIATRWVEADERISSNLLVPVGSQVLYARRLRLANGTPIGFERVYLVPDAASTVLDPTVSQAFAGGSPQEEGSEYTVEHGRMRIEASLFSEQDAADFNGFPTVGAAALQVTLTGYTGEGEPVEYSVTLYESAAYFYEMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY12</accession>
    <name>A0A2Z5QY12_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_03840</name>
        <name evidence="1" type="ORF">RA11412_1049</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87348">
        <property type="protein sequence ID" value="BAV87348"/>
        <property type="gene ID" value="RA11412_1049"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1049"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="111" mass="12997" checksum="701F2FFE43A19D56" modified="2018-10-10" version="1">MEPVAFDDIPLEIFLQDIMDLTRLFPEDFPAEFAKMAARIGVEKQHLFITDFIEDTRDHVVGHYLGYVFDALNRRMYQYEIRGGNKLYLKEVPVEDLTVRDTDSVKVLDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY14</accession>
    <name>A0A2Z5QY14_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptide transport system permease protein DppB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_0825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87124">
        <property type="protein sequence ID" value="BAV87124"/>
        <property type="gene ID" value="RA11412_0825"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0825"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="10"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="148" mass="16130" checksum="1DB28355174AE4D6" modified="2018-10-10" version="1">MTGFWNTTIDLAEHYAVPTFCMTVLGWSAYQIAQRQYLLDNVNADFVRTARAKGLTRNQAITRHALRVSFIPVAQSIAYQVPAIFAGAFFAETVFAWPGIGKWSIDAISQQDVNAATATLAYGSVLFAIGAIIADIATSIVDPRVRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY35</accession>
    <name>A0A2Z5QY35_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87253">
        <property type="protein sequence ID" value="BAV87253"/>
        <property type="gene ID" value="RA11412_0954"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0954"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="69" mass="7860" checksum="A4630C95052D0EA8" modified="2018-10-10" version="1">MHRLQPLIGQLNKRQYGAHAGNGLNIPKLACRRCVPIVPQRILKKARVAKRRAGCIHGLLLRKKMRGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY71</accession>
    <name>A0A2Z5QY71_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_0961</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87260">
        <property type="protein sequence ID" value="BAV87260"/>
        <property type="gene ID" value="RA11412_0961"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0961"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="416" mass="43011" checksum="366419E14BB6515C" modified="2018-10-10" version="1">MRGYCAALGVGVIEVVAFGHDETLHPIITYYSSTPRRVVALVVVGFCVAVTWYVLQSRRWGGGPLASVESMVRAQSLAERRPGFVRQGVHALVQIVAVGAGSPVGKEVAPRELGALFAGRIADWGRLPEGTRRTLVASAAAAGLAADYQVPVAGVVFLFEALGLGLSVKNVLVGAFTVGVATATAHLTISDQATYPVVLVQTCWESLALAVLLGVVLAPGALWFRRLLGWAQRGRATNRGVLWRVPLVFAAVGVVSMVLPEVMGNGRALVQQTFNRAELVGSFTVPALLYTLGLFVAKGVLVVAALRHGSYGGTLTPGVALGASGGFVVAGTLVCVCPWVSGFPLGVTGLLSAAGVLGAAVFLALSMDAPLSSVALVVGFTGQSWGAYVPLAVAVGVAWGVKRLWEAHRARVLAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYH3</accession>
    <name>A0A2Z5QYH3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87403">
        <property type="protein sequence ID" value="BAV87403"/>
        <property type="gene ID" value="RA11412_1104"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1104"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="2"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="170" mass="18939" checksum="66A0D1714B26E85D" modified="2018-10-10" version="1">MVSEYRICAAGCFIADSTVLEAVAFGLEPHEIDEERVRYCLEIAELTEVVESLDEGIMTMIGHNAVRLSGGQRQRLGIARALYRNPSVLIMDEATSALDNETEHKITKAIEKISKDITVIIVAHRLSTVRHVDQLVYLSHGEIVSCGTFTEVQQKNEEFANLVRLGQLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYM7</accession>
    <name>A0A2Z5QYM7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3046 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Protein of uncharacterized function (DUF3046)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_03000</name>
        <name evidence="3" type="ORF">NCTC10207_00676</name>
        <name evidence="1" type="ORF">RA11412_1269</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888983.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87568">
        <property type="protein sequence ID" value="BAV87568"/>
        <property type="gene ID" value="RA11412_1269"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1269"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021408">
        <property type="entry name" value="DUF3046"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11248">
        <property type="entry name" value="DUF3046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI22595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="73" mass="8225" checksum="408A0D690C5EB699" modified="2018-10-10" version="1">MKLSEFWLCMEHEFGRGYARVLAADLVLGQLGQLTALEALEKGVDPRRVWLAICDTQDIPLERRLGPDIKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYN4</accession>
    <name>A0A2Z5QYN4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Capsular polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87420">
        <property type="protein sequence ID" value="BAV87420"/>
        <property type="gene ID" value="RA11412_1121"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1121"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="72" mass="7980" checksum="9B8BE5CBF5AC1AAE" modified="2018-10-10" version="1">MIMVGSIGKSHREQMTEATNNLNKVNANLFGLVLNRAPRKGLGNSYYGFGYANSYVGYATYYGYSKDGTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYS3</accession>
    <name>A0A2Z5QYS3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Biotin carboxylase</fullName>
            <ecNumber evidence="1">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_1161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.14" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87460">
        <property type="protein sequence ID" value="BAV87460"/>
        <property type="gene ID" value="RA11412_1161"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1161"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="22"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="141"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="512"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="570" mass="61471" checksum="7043808EF744BC6F" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYV7</accession>
    <name>A0A2Z5QYV7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SRPBCC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03320</name>
        <name evidence="2" type="ORF">RA11412_1191</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87490">
        <property type="protein sequence ID" value="BAV87490"/>
        <property type="gene ID" value="RA11412_1191"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1191"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="156" mass="17522" checksum="932CC94D4CE4C642" modified="2018-10-10" version="1">MSTADNPNTPPRPQRIISSVIIQNTPPQRVWEAITQPEFTSQYFFGSRVEVTEDEPGRLRYLSPDGKEVWGDGAILESDPPRLLVVEWRSLYLPDAAHEPASRVTWQLEPWTDGATKLTVTHDRLEDSPVTAQNVASPRGWSFVLAGLKRVLETGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYW9</accession>
    <name>A0A2Z5QYW9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase/carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87500">
        <property type="protein sequence ID" value="BAV87500"/>
        <property type="gene ID" value="RA11412_1201"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1201"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="257" mass="28279" checksum="8F030007D39A105A" modified="2018-10-10" version="1">MGCMSENTYIVEYSRPEDERAGTHLVLLLHGYGSHEKDLLSLAEHLPQEGITYAGMRAPQPVGTQFSADATGAHIPDEAIGYQWYPLDQQLNADVRTIEQASDYVLEWVEQHESHYASVSLVGFSQGMAVATSMVRHRPGKFAALVGLSGYAVESDSPYFKDDELKATELPVFFGRDQEDPIIPQPFVDYTYEWIRAYTDGIKVLYAGAGHGVSALEIRHVGEFIDVKVLGNAPRIRAEKVADAADNAGVSEQESAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYY8</accession>
    <name>A0A2Z5QYY8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_1363</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87662">
        <property type="protein sequence ID" value="BAV87662"/>
        <property type="gene ID" value="RA11412_1363"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1363"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="7">
        <location>
            <begin position="31"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="8">
        <location>
            <begin position="416"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="600" mass="65093" checksum="43A9A83355916452" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYZ6</accession>
    <name>A0A2Z5QYZ6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dicarboxylate/amino acid:cation symporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Proton/glutamate symport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_03430</name>
        <name evidence="7" type="ORF">RA11412_1165</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87464">
        <property type="protein sequence ID" value="BAV87464"/>
        <property type="gene ID" value="RA11412_1165"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1165"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="465" mass="48198" checksum="F2F5ACFDD14830EE" modified="2018-10-10" version="1">MANTRTFRFPSWAASFGNQIIASLLIGIGLGFAATALGGDAKNNPNWLMATLDAIGTSYVTLLKAAVIPLVFTAVVASISNLSQVTNAARLAVKTLIWFAITAFFAVSIGIVLGLLVQPGVGAEVSASGSTSTRGSWTAFLTGIIPSNFLGLEVTTKTTGSGITSSVSFNVLQMLVISGAIGIAALKVGDAAKPFIDIVKSALAIIQKVLWWIIRLAPLGTIGLIGHAVYAYGWTSMGSLVKFIAALYAGLLLVFLVVYPLIVKFNGLSVKQYFSGVWPAVQLGFVSRSSMGTMPMTEAVTERNLGVPRAYASFAVPLGSTTKMDGCASVYPALAAIFVAQFYGVHLDISQYLLIILVSVLGSAATAGTTGAIVMLTLTLSTVGLPLDGVGLLLAIDPIIDMGRTALNVAGQALVPAIVSKREGILNEQLYNAPRGADGFVDQALVDAVHTEPVPSAASQQPTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ26</accession>
    <name>A0A2Z5QZ26_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Insulinase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_03070</name>
        <name evidence="5" type="ORF">RA11412_1252</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87551">
        <property type="protein sequence ID" value="BAV87551"/>
        <property type="gene ID" value="RA11412_1252"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1252"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="43"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="199"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="443" mass="48540" checksum="3C0464FA6CAEC6BA" modified="2018-10-10" version="1">MAISLPVVPGEIAEELDYERGRLIFAGADSNEVRRSILPGGVRVITERMPGTRGVSIGFWAGVGSRDEAPGMLGSTHFLEHLLFKGTASRTALDIAQAFDEVGGESNALTAKEHTCYYARVLDDDVPMAIDVLADMVSNALLDPEHLEQERGVILEELAMDQDDPTDVAFENFVEQLMGDNPLGRPIGGTPQEIMQVPREAVWEHYKQYYTPDRLVVSAAGSLEHSRIVNLVLDALTRSGWNLREGVAPAPRRVRTESGIVPFSELREVQKGFEQTNIVMGCPSIIAGDERRYAMSVLSSAFGAGMSSRLFQEIREKRGLAYSTFAFSGAYSDAGYFGMYAGCLPAKTEQVCELLQYEFDKLVFAGITAEELSKVRGQLAGSTVLGSEDSGSRMSRLGHAELESGRFTSTDELLQKIRAVTLEDVHGLARYLGQQQMITTIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZC5</accession>
    <name>A0A2Z5QZC5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_1331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87630">
        <property type="protein sequence ID" value="BAV87630"/>
        <property type="gene ID" value="RA11412_1331"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1331"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="7">
        <location>
            <begin position="55"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="283" mass="30633" checksum="F6910E200F8A4846" modified="2018-10-10" version="1">MLILSTDISSDLASYTASLDGESPERLAHVQNRLAQLKNLTRKYGADITEVLDWAQASRARLNTLIDDPTRQENLEAELVTLRQKLGEQSQTLLEARRGAARTLAEAVSEELTALAMPNASLIVEVSEAEKFSPYGKDTVTFMLAPHKNAAPRPLGKGASGGELSRVMLALEVVLAEVDPVPTFIFDEVDSGVGGKAAIEIGRRLAMLAQHVQVLVVTHLPQVAAFADQHILVLKNDDASLSKVQVLTDEQRVVELARMLAGHDQSEAAQEHARELLHAGGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZE9</accession>
    <name>A0A2Z5QZE9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DNA-3-methyladenine glycosylase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_02655</name>
        <name evidence="1" type="ORF">RA11412_1351</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87650">
        <property type="protein sequence ID" value="BAV87650"/>
        <property type="gene ID" value="RA11412_1351"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1351"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="228" mass="25575" checksum="9E73719D04940A6C" modified="2018-10-10" version="1">MAIGTGDHAPREKYPAWVRNDLERDYYDTEWGVPVTDERGMLERVCLEGFQSGLSWYTVLVKRPAFRELFANFVPDALVKFTNDDVERLLQDERIIRNRLKIQATISNALLTIELRDRAAAGDTSLAGFYLPNGQWVEPGLPAFIWSFLPERTITPRELSEVPAQDDVSAAMAKAFKKLGGKFLGPTSCYALMCAIGMVDAHLLDSHRRGVMGLFDENGRLLPSPKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZF6</accession>
    <name>A0A2Z5QZF6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-containing alcohol dehydrogenase and quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="370"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87736.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
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    </evidence>
    <sequence length="372" mass="39723" checksum="E8BAA10E6483806A" modified="2018-10-10" version="1">MLLVSERLIRDGGTALVYFLMVLLALTAVTLRELGNRFSNRTSREVTVTDTMQQVQLVEWGGPEVLHLAEVPVPEPVRGHVVVRVQAAGVNPIDTTTRKGLGPAAQLADTSKPVVLGWDIAGVVTAVAGDYTGFAVGDRVFGMVNFPVLGNTYAQYALVPAYQLAHAPDNVPMEQLGAAPLAALTAYQALFEVARLAAGERILIHAGTGGVGHMAIQLAAAAGAQVYTTASARNREFVESLGAVCIDYTSEDFREALADDGEHIDVVLNSTGAQTFLDSLDVLAPADRIFAPAGRIVTLTSPDPLEAARERGFTAQWLTVHPDAGQLTKIAHYLQEGTLRVHLDRVFPLAEAAAAHEYIEQRHARGKVVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZJ2</accession>
    <name>A0A2Z5QZJ2_9MICC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="BAV87915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="39" mass="4309" checksum="A54E48F718030435" modified="2018-10-10" version="1">MGFFGGVMVSLFVGVPGQARPVLRTVRVRVLCLKYADIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZK6</accession>
    <name>A0A2Z5QZK6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87721">
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        <property type="gene ID" value="RA11412_1422"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1422"/>
    <dbReference type="Proteomes" id="UP000250241">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
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    <feature type="chain" id="PRO_5016369366" evidence="3">
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            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="267"/>
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    </feature>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="573" mass="63577" checksum="6A70E6534F0F8E94" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZM2</accession>
    <name>A0A2Z5QZM2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">sbcD</name>
        <name evidence="12" type="ORF">I6I94_02005</name>
        <name evidence="11" type="ORF">RA11412_1514</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SbcD family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT89425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87813">
        <property type="protein sequence ID" value="BAV87813"/>
        <property type="gene ID" value="RA11412_1514"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1514"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026843">
        <property type="entry name" value="SbcD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12320">
        <property type="entry name" value="SbcD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 7 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="9">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="400"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363069"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV87813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT89425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="419" mass="46257" checksum="03F919D7E6D7DC53" modified="2018-10-10" version="1">MKILHTSDWHLGRTFHGTSLHDVSERFIDELIATVAEENIDAVLISGDVYDNATPSTETIQLLNRALTGLVAVGAQVIFSSGNHDSPRRLGFGAELFATAGVHIMTRCEQAWQHPVILSKDGVRVGVYAIPYLNPRYHGPVLGVEPTHAGVLGAVTERIRENIAELRKEGNLDYSIVLAHAFITRAPAAREQEDTGGEQAALTEPDRSDSERDISIGGVEAAPASLFDGIDYTALGHLHGRQRVSDTIRYSGSPLAFSFSEENHVKGAWLLTLTRDAGGVSASIDPINWDTTLHLKTLRGTLTELLNNPAFEPYEDAFCRIYLEQENRPLNPVEQLRKRFPHIASFEFRSTVEQLQRSPYHRTRENITPQVMCREFYAYVRGAPLSEREEEILTAIIEEATEPGGDAADSKASVCSSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZN5</accession>
    <name>A0A2Z5QZN5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_01720</name>
        <name evidence="4" type="ORF">RA11412_1608</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87907">
        <property type="protein sequence ID" value="BAV87907"/>
        <property type="gene ID" value="RA11412_1608"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1608"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="3">
        <location>
            <begin position="122"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT90051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="278" mass="30511" checksum="DB7EB1CC22A497C5" modified="2018-10-10" version="1">MDPKKRRLLYTLIAIAVVILLIIAVIYVGRHGTGGLFEANPSASSSPNTGEEDEPDVKTETLQEVKNPYDAVDPTTALAPDLATVKKELSSLPVKERASKNGYSREQFGAAWEDVDKNGCNTRDDILRRDLTDVRFKAGTRACTVITGKLADPYTGKTIDFKRGKKTSSAVQIDHVVALSDAWQTGAQDIDEQKRRELANDPENLVASDGPANMQKSDSDASEWLPGNTAYRCTYVARQVHVKAKYKLWVTPDEKRAMENVLNSCKSTNPGKQKAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZQ9</accession>
    <name>A0A2Z5QZQ9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="9">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gltX</name>
        <name evidence="14" type="ORF">I6I94_01855</name>
        <name evidence="13" type="ORF">RA11412_1554</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="9"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888664.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87853">
        <property type="protein sequence ID" value="BAV87853"/>
        <property type="gene ID" value="RA11412_1554"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1554"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020752">
        <property type="entry name" value="Glu-tRNA-synth_I_codon-bd_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="11">
        <location>
            <begin position="16"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="12">
        <location>
            <begin position="356"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="265"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV87853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT89398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="502" mass="56100" checksum="FCA9630E84B5F281" modified="2018-10-10" version="1">MTEYRGPALADASQTRVRFCPSPTGTPHVGMVRTALFNWAYAHHTGGKLVFRIEDTDAARDSEESFNQVLEGLHWLGIDWDEGVGVGGPHEPYRQSQRMDLYAEVIQKLKDGGYIYEDFSTPDEVRERRKAKGEDPQLGYDNYDRTLTEQQKEAFRAEGRQPVWRLRMPEEDITFNDLVRGEITFRAGSVPDYVVVRANGKPLYTLVNPVDDALMGITHVLRGEDLLSSTPRQIALYRALIDVGVTEFIPEFGHLPYVMGQGNKKLSKRDPESNLFLLREAGFIKEGLLNYLSLLGWSLSADQDVFTVDELVQHFDVHDVVGNPARFDVKKAEAINGDHIRRLDAADFRGRLVPYLQAAGVLGEPLSEQQEQVLTQAAPLVQERMQLLGEAPKLLAFLFTADEDITVADDARKQLKESAPQVLAAAIEALEPITEWDSSHIEAALRSAIVEGLDIKPRLAFGPVRIAVSGERISPPLFESMQILGKESSLKRLRKLAADLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZV1</accession>
    <name>A0A2Z5QZV1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excinuclease ABC subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88002">
        <property type="protein sequence ID" value="BAV88002"/>
        <property type="gene ID" value="RA11412_1703"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1703"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH1" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="144" mass="15294" checksum="C56BCAB9BF1D2A03" modified="2018-10-10" version="1">MLVDGGPPQVAAAQAALSDLGVVDVHVAGIAKRLEELWLPDDDFPVILPRNSQALFLVQRIRDEAHRFAITFHRSKRGKAMVASALDAVPGLGPAKREALIKHFGSLKNLKAASADELTQVQGVGPSLASKIREHFDAEAAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R015</accession>
    <name>A0A2Z5R015_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_1773</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88072">
        <property type="protein sequence ID" value="BAV88072"/>
        <property type="gene ID" value="RA11412_1773"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1773"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="247"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="406" mass="45966" checksum="CB0499610E588AB4" modified="2018-10-10" version="1">MISVQNLELRAGARLLMEEVTFRIDKGDKIGLVGRNGAGKTTMTKVLAGLNLPADGTITRSGSIGYLPQDPKVDDMSQLAKDRILSARALDGVARKMRQAQDDMASEDPTVRAKGMRRYDRLEAEFIAGGGYAAESEAAVITSNLDLPERVLSQPLSTLSGGQRRRVELARILFSNADTMLLDEPTNHLDADSILWLRDFLKNFSGALLVISHDVELMELVVNRVFYLDANRCVIDQYNMGWKNYLMQREQDEHRRKRERANAQKKANALLEQANKMRAKATKAVAAQQMIKRAERLMRGVQEERQVDKVAAIRFPDPAPCGKTPLSARGCRNPMVHLRFLQTLIWPLTGVHGWWCWDSTVRVRPPCCVCWRVRLSRIQVRWCMVTGRSWGISRRSMKFLRVSALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R017</accession>
    <name>A0A2Z5R017_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster assembly protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88058">
        <property type="protein sequence ID" value="BAV88058"/>
        <property type="gene ID" value="RA11412_1759"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1759"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="88" mass="9715" checksum="93EA78AFE206B6C1" modified="2018-10-10" version="1">MPNTEETLGYHAPIIPGMDQEGEKLASELVHDDTILRATEEHHQGSNPNNVQKTLDASRAERMTSYKVEDFSPSPAVKRTGVSPRLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R024</accession>
    <name>A0A2Z5R024_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88082">
        <property type="protein sequence ID" value="BAV88082"/>
        <property type="gene ID" value="RA11412_1783"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1783"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="149"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="295" mass="32405" checksum="136355DCABB16E54" modified="2018-10-10" version="1">MQHIKSMRKKQLSAADIAARTERVHAISSVVPLEQAPEQALQYYTHLTDVKLRSVLEPQWGIYIAESSKVVRRALDAGHQPLSFLMSEKWADDLADVLRAHPEVPAYVGPEQALEGVTGFHLHRGALAVMARPAPVPLEQLVAEAFRVAILEDIVDHTNVGAIFRSAAALNVDAVLVSPRCADPLYRRSIRVSMGTVFQVPWGRLTSWPDDLELLHSMGYETAALALHHDSLTLEELSSRRYPKLALIMGTEGHGLSARTLAAAKHTVMIPMSHGVDSLNVAAASAVAFWETRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R025</accession>
    <name>A0A2Z5R025_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRISPR-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87870">
        <property type="protein sequence ID" value="BAV87870"/>
        <property type="gene ID" value="RA11412_1571"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1571"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010147">
        <property type="entry name" value="CRISPR-assoc_prot_CasD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01868">
        <property type="entry name" value="casD_Cas5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="223" mass="24929" checksum="7809961D77C72193" modified="2018-10-10" version="1">MQSWGTQSRYRRRDSGHEPSKSGVIGLIAAALGRARTEPVDDLARLNFAVRVDAPGTLLRDYQTAKDWATDPNGAASLSTRYYLSDAVFVAAVEGDQEVLKNIESALKKPVYPLYLGRRSCPAGYDLVLGIREESAEEALRNEEWHVPEHRRAEFPDPVQLRILRDAKSGEQGDLVQDVPVSFNQEHRQYAVRAVVSAEPKTVENPKGKRHSDVNFMRTVTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R042</accession>
    <name>A0A2Z5R042_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87834">
        <property type="protein sequence ID" value="BAV87834"/>
        <property type="gene ID" value="RA11412_1535"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1535"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015315">
        <property type="entry name" value="DUF1963"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035948">
        <property type="entry name" value="YwqG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09234">
        <property type="entry name" value="DUF1963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103032">
        <property type="entry name" value="SSF103032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="155" mass="17825" checksum="FD7271E2CDAB40EE" modified="2018-10-10" version="1">MNDDEHDICLPVEHECALEFVVLEHEIFSPCKDSVNHPLIEKWNQAYPEQTIKSLFDLDDFEDGDVLEEIEKFTGSRDYSKIGGLPDFVQGDPRYYHENAEEHGCTVNLLTMDSVWDGEEYLVIWGDGGTANWLIAPDRLAARDFSQVFYEWSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R070</accession>
    <name>A0A2Z5R070_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87864">
        <property type="protein sequence ID" value="BAV87864"/>
        <property type="gene ID" value="RA11412_1565"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1565"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="97" mass="10962" checksum="833C7C4B577FA815" modified="2018-10-10" version="1">MCTIDQILMMALQSRHVMLRHLGLGSKVVIIDEVHAYDAYMGVYLKEALYWLGQMNAPVILMSATLPAHVRTSLMESYAEGLEIQDSTDWTLMMVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0A1</accession>
    <name>A0A2Z5R0A1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-L-isoaspartate methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88147">
        <property type="protein sequence ID" value="BAV88147"/>
        <property type="gene ID" value="RA11412_1848"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1848"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="167" mass="18180" checksum="AEC54916E40A31CE" modified="2018-10-10" version="1">MTNTHGVQYQALRPLYKDFVLSMPRGAAVVYPKDAAQIIVKGDIFPGARVVEAGVGSGALSIALLRAVGDDGRVHSFERRAEFAEVAQANIETMFGGPHPAWALSIGDLQDTLPEAEQPGSVDRVVLDMLAPGSAWMRWLRRLPPAGCWSATWQLLPRCPAWWRGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0A9</accession>
    <name>A0A2Z5R0A9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">ABC-type multidrug transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I6I94_01085</name>
        <name evidence="9" type="ORF">RA11412_1754</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88053">
        <property type="protein sequence ID" value="BAV88053"/>
        <property type="gene ID" value="RA11412_1754"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1754"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="39"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="273" mass="28972" checksum="F2139B00AF8FBCDE" modified="2018-10-10" version="1">MTQTAPTGPASESPAEADTFTEPRAASGVQRVLAQGGYETLAMLKNGEQLMLNIAFPVMALFALRYTSFLDSYAEGMGTTRMNVAVPGVLALCVISTALSGQGIATGFDRRYGVLRFLSTTPLGRNGLIIGKVIAVLTVLAIQFVLVSIVGFGLGWRPDIFQMYRSLSTLLLGAAAFTALGLFIAGTVRAEATLAIVNIAWVILAGAGGVLIPIDSFPEVYRVIVSLLPSGALGEAMRGDYLKDVFLPLPHLVLLGWALIVGFIASRKFKWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0D5</accession>
    <name>A0A2Z5R0D5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trp biosynthesis-associated membrane protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Tryptophan-associated membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_01610</name>
        <name evidence="3" type="ORF">RA11412_1635</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87934">
        <property type="protein sequence ID" value="BAV87934"/>
        <property type="gene ID" value="RA11412_1635"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1635"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019051">
        <property type="entry name" value="Trp_biosyn_TM_oprn/chp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09534">
        <property type="entry name" value="Trp_oprn_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="233" mass="24216" checksum="357D1C95F58DDFA3" modified="2018-10-10" version="1">MSDEPDSGRADGQNPHENTGAQESSMEREPATPDAIASEQQAKERSTRPGLVMLSGLLVAAAAFGTTLLTWVDARITGAFGEQSLAVSGSKAAPAVSALALVALAAPLAGRIAPRLLRYVVYGVAAAAGVGIVLSVIAVTSNPAAAVVTETSRLTGTISPAGEYALSPWPWVSAACGVLIIVVALWAAFTSRTWDAGRRYERSAARSVHTEDGHMDEMDAWDSLSRGEDPTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0G1</accession>
    <name>A0A2Z5R0G1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2Fe-2S iron-sulfur cluster binding domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ferredoxin 2Fe-2S</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Putidaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">camB</name>
        <name evidence="4" type="ORF">I6I94_07995</name>
        <name evidence="5" type="ORF">NCTC10207_02017</name>
        <name evidence="3" type="ORF">RA11412_0040</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887635.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86339">
        <property type="protein sequence ID" value="BAV86339"/>
        <property type="gene ID" value="RA11412_0040"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0040"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="PTHR23426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI24307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="106" mass="11462" checksum="7A444CE04C66F36A" modified="2018-10-10" version="1">MGVMIKVTDETGDSREVEWEEHHTLLESLLSHGFPVLATCGGNASCATCHAFIDPEHIAASGERTDAEADLLDMVDDVANEYSRLCCQVEYTPDMDGASITLQAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0H5</accession>
    <name>A0A2Z5R0H5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88227">
        <property type="protein sequence ID" value="BAV88227"/>
        <property type="gene ID" value="RA11412_1928"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1928"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="265" mass="30976" checksum="993A8AEBBBB0303E" modified="2018-10-10" version="1">MSLFERILDLSFMDSTITQKIIDFSQILVRELVFGKDAQGRDLILNKVEKAAEIYFNRIKDTLKGKIEEYIDSGSNQEIYSYLLMIIIFNYDKKMDLNSVNDICHSVIQSRIDDINMILATIIYYRKNRNYDGIAEVMARALWDAHYPVCSKKEELDTNPDPWYRKPCDCGYEFSDQLWMYRYYLYFMYHAGNNQGQACKGSAYLYFEKSIKNVVIDGVTVDLGKHFTFRNLSNLSEVNKFYKTMLDGGVKIIDDGDAEFIYSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0H9</accession>
    <name>A0A2Z5R0H9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88228">
        <property type="protein sequence ID" value="BAV88228"/>
        <property type="gene ID" value="RA11412_1929"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1929"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="318" mass="37633" checksum="52201495D5CC60EA" modified="2018-10-10" version="1">MSAESLIKYGYFDSLANKFINRSGAYKEEQYISNDQFYEGIFNLSEFYNWLNDGDRWKHFYFSQEFGKARIRKEWTTPTSFTIPKNLHTRREYKLINLFSYGNLAYYIEQEKEVISNIFLQNKNSMSKFFGSEVFKFAITQDLRSTLLFGKNKRYITDVQNFYHSIYTHSIEWMLDGKDNAKRNIGVRNWKDYTFGKSLDRLIQNSQSGETHGLPTGNLITRIIAEVYMCKFDEILLNINKGYSFSRFVDDIVFAFNTDMELIDFKKSLNEKIREYSLSLNDSKTKIESFPFEGNKNKDAIFAFFDTLPEMPKKQTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0K9</accession>
    <name>A0A2Z5R0K9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88315">
        <property type="protein sequence ID" value="BAV88315"/>
        <property type="gene ID" value="RA11412_2016"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2016"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="123" mass="13837" checksum="1BD1B74E23376062" modified="2018-10-10" version="1">MQETKANNTMRRDPTRWAVGFKTTYDVRKIVVLLEDTPPAVLFHCVAKYPDFTVISKKDGETKEQKVAAKERSVRLVMVYLDGNWRLISNSYCQEKYPKIYAQGASGEKNSPESASTSSSGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0U9</accession>
    <name>A0A2Z5R0U9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86499">
        <property type="protein sequence ID" value="BAV86499"/>
        <property type="gene ID" value="RA11412_0200"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0200"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="95" mass="8876" checksum="74E92C0C2DD6B1E1" modified="2018-10-10" version="1">MGVYSGSAVGGVNSPAGAPVTASPAGWATGCAAGGTVVAGASTCGAYTRPAELPPPVQGSALAAEPGLVRVPAPVGELELVRVPAPVRESAGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0V9</accession>
    <name>A0A2Z5R0V9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86509">
        <property type="protein sequence ID" value="BAV86509"/>
        <property type="gene ID" value="RA11412_0210"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0210"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="1">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="127" mass="14157" checksum="9BF62EBC6EE43AF8" modified="2018-10-10" version="1">MPYCAKAEPTYEKVAKDLEGTMNVTVRNMPLSSHKNAVPAAQAVQAAELQGKHLEMANKLFQTQDSWKGITDKQTELRGLFLSYAQELGLDTEKFKTDLVDPKTLELVKGDFEYGHKIGVKGTPNSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R107</accession>
    <name>A0A2Z5R107_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Shikimate kinase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88186">
        <property type="protein sequence ID" value="BAV88186"/>
        <property type="gene ID" value="RA11412_1887"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1887"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="154" mass="17122" checksum="44CAC0A3CD3C2348" modified="2018-10-10" version="1">MEHKDADGMIHPQQVREMQESFAEMTRPIVLIGPMAAGKTYIGTHLARFYGYEFLDADQLIVERYGEVSEIFEIFGEAHFRELEVKVIEEVLTSPAYRNTVFSLGGGAPMTDAVAQLLRGQNVVYILVDAPTVEPRITGSKPARCCSLTRAAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R152</accession>
    <name>A0A2Z5R152_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methylisocitrate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.99</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(2R,3S)-2-methylisocitrate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Probable 2-methyl-cis-aconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RA11412_2103</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.99" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88402">
        <property type="protein sequence ID" value="BAV88402"/>
        <property type="gene ID" value="RA11412_2103"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2103"/>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="12">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV88402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="144" mass="15332" checksum="F0EA21EC67EF1ACC" modified="2018-10-10" version="1">MPSPDDFEDENEKAAAARALEYMNLTAGTPMKDIPVDVVFLGSCTNSRIEDLRAAANIIRGRTMAPGVRMMVVPGSQKVRAQAEEEGLDKVFKDFGADWRFAGCSMCLGMNPDQLAPGSGAPPPQTAILRGGKAKADVPTLSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R179</accession>
    <name>A0A2Z5R179_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88244">
        <property type="protein sequence ID" value="BAV88244"/>
        <property type="gene ID" value="RA11412_1945"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1945"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="3694" checksum="4F41C1B6851F097B" modified="2018-10-10" version="1">MFTQAGASLALLGTEVLRSSTAGSAGLCAVNIALGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1E8</accession>
    <name>A0A2Z5R1E8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Protease synthase and sporulation negative regulatory protein pai 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_10640</name>
        <name evidence="2" type="ORF">RA11412_2209</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88508">
        <property type="protein sequence ID" value="BAV88508"/>
        <property type="gene ID" value="RA11412_2209"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2209"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
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        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="173" mass="19413" checksum="44120552ABFA6DFD" modified="2018-10-10" version="1">MSVSLRELTVADAAVLRNISIATFTETFADSNSAADMALYIAQRFSEDQLAQELANPESFFYTAEVQGQTVGYLKLNTGGAQTEPQQENALEIERIYVLGTHHGHGVGQALYQHALTVANQRAASYIWLGVWEHNHRALRFYQKNGFTAFGQHIFHLGDDEQTDILMKHDLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1K1</accession>
    <name>A0A2Z5R1K1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA modification methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88665">
        <property type="protein sequence ID" value="BAV88665"/>
        <property type="gene ID" value="RA11412_2366"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2366"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="91" mass="10688" checksum="D0A7EFB2DD7108EB" modified="2018-10-10" version="1">MNELIWAYDYGAKSTKRWPTKHDNILMYVKDPQKYYFNADTVDREPYMAPGLVTEEKAARGKLPTDVWWHTIVSPTGKEKPATPRRNRWGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Q1</accession>
    <name>A0A2Z5R1Q1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dnaA</name>
        <name evidence="15" type="ORF">RA11412_0480</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the DnaA family.</text>
    </comment>
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        <property type="protein sequence ID" value="BAV86779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86779">
        <property type="protein sequence ID" value="BAV86779"/>
        <property type="gene ID" value="RA11412_0480"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0480"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="13">
        <location>
            <begin position="290"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="14">
        <location>
            <begin position="502"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="91"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="298"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV86779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="600" mass="65770" checksum="130B07F3D397FFF7" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Q8</accession>
    <name>A0A2Z5R1Q8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mrp protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88677">
        <property type="protein sequence ID" value="BAV88677"/>
        <property type="gene ID" value="RA11412_2378"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2378"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="260" mass="27046" checksum="C7DFAA2DE16DEEB4" modified="2018-10-10" version="1">MTANLAAAFASRGLAVGIIDADVHGFSIPGLLGVHEAPTRLDDLIIPPAVDAPREHGQVRGGSPGGFVKVISIGMFLKGNQPVAWRGPMLHRALEQFILDVHFGALDILLLDLPPGTGDIAISMSQLLPNAELVLVSTPQHAAVDVAERAGTLSLQTHQKVSGVIENMAAMTLPDGTVLEMFGSGGGAQLAQRLSSVLNYPVPLLGSVPLDVSLRTGGDEGNPIVWGDPSSPTSAEIQAIAGKLLHRDESLAGKPLRLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1T2</accession>
    <name>A0A2Z5R1T2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88643">
        <property type="protein sequence ID" value="BAV88643"/>
        <property type="gene ID" value="RA11412_2344"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2344"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="216" mass="23770" checksum="8980FF334FA620E6" modified="2018-10-10" version="1">MSVLLSYAVVGVIPIFVALHLSYVRRRAAQEKTQTPRRGRYPMWVFVAFDVVGGVICCAVAVTGAVLISSSAGSHQIMMLILWGGGTCLVLLAYALGVWGITVTYVEMLPDALAARGFFGGTRIIAFEQIGGYIYDPMYRDVVSVEEDRRNLHMRRWHSYSVVHRDKLQVMDKEGNVAFATRVAGTPLPHYAGQCIMFQGCRAGGRSRVPMTMSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1U4</accession>
    <name>A0A2Z5R1U4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Phosphatidylethanolamine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09770</name>
        <name evidence="2" type="ORF">RA11412_2418</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88717">
        <property type="protein sequence ID" value="BAV88717"/>
        <property type="gene ID" value="RA11412_2418"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2418"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="89"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="249" mass="28500" checksum="A4CE7B8D320131B0" modified="2018-10-10" version="1">MANTNLTNKLKPEFRTNPPAEENGILMCLDDAQVQGDNAKYMKFYNRIATVYDLGERWFGRLAYGNEVAQMRRQFMKELEWFPGCSALYVSIGTGTDLRYLPDDIEVSAIDWTGADISLGMLKKCQKIWGGRANLNLVNCAAENLPFADQSFDVVLHVGGINFFSDKKRAIEEMIRVAKPGTKIMIADETSDYIDSQYKKSIFTRKAYKDATFDLSEIEALIPSTVEDARTELIWDDQFYYITFRTPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Z7</accession>
    <name>A0A2Z5R1Z7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkaline phosphatase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Alkaline phosphodiesterase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_10670</name>
        <name evidence="2" type="ORF">RA11412_2202</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88501">
        <property type="protein sequence ID" value="BAV88501"/>
        <property type="gene ID" value="RA11412_2202"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2202"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="413" mass="44905" checksum="CD575EAF1009AE8A" modified="2018-10-10" version="1">MSVSGTAYNDAAGTPVPPPPAYGSNSVADVFESAASLLAQSSLEHPAHPLGNTSRDPLALAKRLREAGADPNGFRNICVVMVDGLGEQLLQTYGSYAPYLKKTVSLGPLDAAFPTTTAASLTSFGTASAPGAHGIAGYEVRNPATGTTMNHLSGWDKTVDPHTWQPLPTVFERYSTQTRVVTISLDKYRGSGLTEAGLRGGEFVGATGYDARITYATELLASRTPTLVYLYWGELDQAGHRHGAGSDTWLEQLEELNLALRRLAQRAPAWAGIFLTADHGMVNIPEQERIDYSHDTELLNNVALTAGEPRAVQLYLHDTSEAARTETARRWATAWGERAWVLDSRDLYTRGYMGPTVSEAARERIGDILVCARDNIALYDMRHYKEQSLKMVGQHGSLTDAERRIPLLYLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R211</accession>
    <name>A0A2Z5R211_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88642">
        <property type="protein sequence ID" value="BAV88642"/>
        <property type="gene ID" value="RA11412_2343"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2343"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="164" mass="18121" checksum="C2B5F700BCE627DD" modified="2018-10-10" version="1">MNLYFIRAFLHPILVRHAAQAPTTPDGTVRVRMYWMHALPGFTSIFLGLLFMAFAVPAYLSSIGQLIITVLFALLFFIMGGIILLAWKNVYIQTGVDYVEQRLWVGVPVRIHFNEIDSFSYNPGNTQLTMSRGSSVGGSPSKPPIIGVSRSSRTTTGVSAPSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R221</accession>
    <name>A0A2Z5R221_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="2">GCS 2</shortName>
            <shortName evidence="2">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_09350</name>
        <name evidence="3" type="ORF">RA11412_2508</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88807">
        <property type="protein sequence ID" value="BAV88807"/>
        <property type="gene ID" value="RA11412_2508"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2508"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="382" mass="43041" checksum="6AB2D83189F82BCD" modified="2018-10-10" version="1">MVAFAHSPQSTIGVEWELALTNKTDGELAPRAEQVLARLGERHPHLLAPSTESVHVTGEFLNNTLEVITGVCTTVAESCRQLAEAVDALRPICDELGLDFFCAGTHPYSRWAQQTVVNKDRYQRVVNRAQYWGRHMIIFGVHVHVGVDSPQKALSVVDALTNYCPHLLAPSVSSPFWEGIDTGYASHRTMLYQQLPSNGLPFSFQTWEQYSAYLDSQVATGAIEDVSEDRWDVRPVPHYGTVEMRYCDGLASLPDVAGIVALTQCLVEHFSRRFDAGERVQVLDPWHAQENKWRAARYGLDAQVVVSNEPRIRPLRDELKDLLDMLRPVAEDLECLPELEQMRRILTEGTGADRQRRVLAQTGSFREVMRDLAEQAKQPPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R268</accession>
    <name>A0A2Z5R268_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_2335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88634">
        <property type="protein sequence ID" value="BAV88634"/>
        <property type="gene ID" value="RA11412_2335"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2335"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="52"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="208" mass="23112" checksum="CC2C40F62E75E3E4" modified="2018-10-10" version="1">MNNNHTETHTPADTLQSDEHLPGVGQGTAGEPSHGGRRILSALEIARELGLNPPTDEQIRIIESPLQARLVIAGAGSGKTATMVDRVVWLVANGFVRADEVLGVTFTRKAAGELRERMRTRLNILRERKLIDLTEQELLEGASEPTVSTYHSYANTLVKDYGLRLGIEQDAQMLGDAQAWQLVAQIVQYWDGELPQGVKARRRQRLIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2G6</accession>
    <name>A0A2Z5R2G6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="162563">
        <property type="entry name" value="M.Rae11412ORF2365P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88666">
        <property type="protein sequence ID" value="BAV88666"/>
        <property type="gene ID" value="RA11412_2367"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2367"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="163" mass="17849" checksum="DA2F54E9EF49F8E8" modified="2018-10-10" version="1">MGLLKRMIAASSRPGDWVLDFFAGSGTTGAAAVELERKFVCVDQNPPAIEVMAKRLNVEEHSFAAYRGVPRGAAVLFTPQRSVGVRGGTSRDALTAASRRALAAQSRKVQESVEPVPGASSVFVRHHSTDAVDKDLRIRGRDVLRRERRRQQLAKERAQTAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2H2</accession>
    <name>A0A2Z5R2H2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="17">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">murB</name>
        <name evidence="20" type="ORF">I6I94_08750</name>
        <name evidence="19" type="ORF">RA11412_2658</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 17">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="17"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88957">
        <property type="protein sequence ID" value="BAV88957"/>
        <property type="gene ID" value="RA11412_2658"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2658"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="16 17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
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        <location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="BAV88957.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QQT88601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="369" mass="39030" checksum="678DDB2865F03AA5" modified="2018-10-10" version="1">MTEKLLSEITTAQVGGPARTYIRATTETEIVEAVSSADAANEPVLIVGGGSNLLVSDAGFDGTVVHIASTGVEELPIPACGGANVRVQAGTVWDDFVQLSIEKEWSGPAALSGIPGTVGATPVQNVGAYGVEVGEFIASVRTWDRQINQFKTFANADLRFGYRDSILKQNMVNGSPRYVVLTVDFQFTLGSLSSPIKYGELAKSLGVQVGERAESALVRDKVLALRASKGMVLDASDRDTFSTGSFFTNPIVPVSALDSLPEDAPHFPVVTRTGVFGTEQQENEEYVKLSAAWLIQHAGFEKGFGLEGDAREIAGGRASLSTKHTLAITNRGDATAEDIFAIARAVRAGVAEKFGVELVPEPVVVNGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2I7</accession>
    <name>A0A2Z5R2I7_9MICC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <location>
            <begin position="266"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="427"/>
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        </location>
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            <begin position="285"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="427"/>
            <end position="499"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAV88975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="506" mass="56503" checksum="C1D748114ED6FB32" modified="2018-10-10" version="1">MRKVANLKYMTNSLQELIDASIFISTEYQARVAELVGAAQWDVDFTAQSLSFETTPPVSLRPYLLGTESENRGTWVWSWQQLGYFPDAVVSAAVQAREAGEKKSLTELSTDEIPLSDSLARRLTLASKTVTGLYAHYPLPAGAGVRAWTLLDGDELVLPEPTMKRVGRVIAQTLQGENIVNQVLAVDSYAKQRGFHIAWDTEATAVLTLTDGALRLWFDEGRMSGIEEAKPQVGPEVLAKCLSQAAEHRAALAQARESLEKVAAAEAQQQNAEREQQAAQKAAARAEAERAEQQERAEAERAAERAKVEREQAERAEREKMAAQKAEREAAQKAKAEREKAEREQAKAEREKVTGVSTTEHLYPDTEAPFDQDPREDSEHGTVTTSTLPAGAYRDGEAEDAYEAETVDLQVHEDEVHTGVTEVVEVQEEHTEISIDEELIHVPEEELEHPEQEPEELPEPLEPEHTEPEHVEPEEHEPEYPEPVQQEHKTDEEGKKKGFFSRFFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2J9</accession>
    <name>A0A2Z5R2J9_9MICC</name>
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        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2688</name>
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    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="252" mass="27395" checksum="8037AD68B2371629" modified="2018-10-10" version="1">MSQVILLTGASSGIGYDTAKDLAAAGHTVYGAARRVEKLEELRPFGIIPLQLDITDEDSIKKAVETIITKQGRIDALVNNAGYGSYGAIEDVTLDEARNQFEVNLFGLARLTQLVLPHMRAQCSGRIINVSSMGGRLTTFMGAWYHATKYAFEAFSDALRMETSDFGIQVSIIEPGGIKTDWGMIAADKLEESAKGGAYESIARKTAENMRRLYSSKSLSDPAIISKAITHAIEAKSPRPVTSSVSWQNPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2M1</accession>
    <name>A0A2Z5R2M1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2501</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88800">
        <property type="protein sequence ID" value="BAV88800"/>
        <property type="gene ID" value="RA11412_2501"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2501"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="97" mass="10834" checksum="633A2F13D5F4B1FC" modified="2018-10-10" version="1">MTDADIIITPDGASTIISHFTDGRLISVDGADFEEAVDIAAWVRSLNPDPDVVLWFTSSAFDGHTVLTPGITPQQVLDQWVDHREHDPYVEYPQYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2N8</accession>
    <name>A0A2Z5R2N8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88726">
        <property type="protein sequence ID" value="BAV88726"/>
        <property type="gene ID" value="RA11412_2427"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2427"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="74" mass="7814" checksum="4D63FF7CD9CD8D4D" modified="2018-10-10" version="1">MRVQAFSVNRVDALVRSGQMRLFTGKRFPKGTGVDVLGEVVGMGHGVMDFKIGDTVWGFSGSIAPAPPAPPPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Q7</accession>
    <name>A0A2Z5R2Q7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87179">
        <property type="protein sequence ID" value="BAV87179"/>
        <property type="gene ID" value="RA11412_0880"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0880"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="120" mass="13468" checksum="4C718A884ED5DBAE" modified="2018-10-10" version="1">MEGYKRYALVVWALPEGVDHVDDVPRDSVALSNYMQCGGSTQAMTVEVRVTQEDGSYEHYVVARKPVADPDAWTTITYNNTPLQVHPEEVFTGEQAAPVFRAYIEDGVIPPRELLRTLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2X8</accession>
    <name>A0A2Z5R2X8_9MICC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89088">
        <property type="protein sequence ID" value="BAV89088"/>
        <property type="gene ID" value="RA11412_2789"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2789"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="72" mass="7717" checksum="9FAACBAC0137F835" modified="2018-10-10" version="1">MKTEPDGDVVTVNSDGSWTKRENDGDTVTVNSDGSFVMIEDGAPSHDRPDVPELPAKPNQNATAPKTPVQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Y5</accession>
    <name>A0A2Z5R2Y5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08935</name>
        <name evidence="2" type="ORF">RA11412_2611</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88910">
        <property type="protein sequence ID" value="BAV88910"/>
        <property type="gene ID" value="RA11412_2611"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2611"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="220" mass="24115" checksum="43327CC8B84AFC48" modified="2018-10-10" version="1">MPPEPYTIREARPEELPELLDVLVEAFTPDPFMRVLLGEEPQPEKIRGLFELQLKSLYIPRGFIDVAVDSDGAILGTAQWMPPEGQQGTLKLELRDGPKYLKILGARALRHVIATDIYIRKHRPAFDHWYLHTIGVRATAQGRGVGSALLEHGITRFNGTAAYLEASTPRSATLYTRHGFVPIGTYKGTSPAAGMLYPATIDGVQYDPHSAAANGLLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Y8</accession>
    <name>A0A2Z5R2Y8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_2799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89098">
        <property type="protein sequence ID" value="BAV89098"/>
        <property type="gene ID" value="RA11412_2799"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2799"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="130"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV89098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="305" mass="33071" checksum="E7E19484DA9081AF" modified="2018-10-10" version="1">MSNDAREKARQIAAKQARNNPTKSNRRLLQLGVLAVVLVAVIIVGFVFINGQKQDIPKAGPVPASANEYGGIVITKDGIVKNASKQDQRDADKLGTSDTSITPSASGSATPETLPLGIEKAEEAKKNGKPVHVVIFQDFNCHHCRDFEQANYETIKKLVEDGSITVEYRNMIILDRGSPTQYSARTANAAYAVANQVSADKYLEFQKELFDRQGGGDLNNQQIADIAAKYGANISSDLNDNKWRPLVNVVNEESLNNGVHGTPAIYADGEQFPGPKSEDFPKWVQGKIDAKSSSNRLVCGRPCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Z2</accession>
    <name>A0A2Z5R2Z2_9MICC</name>
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        <submittedName>
            <fullName evidence="1">LSU ribosomal protein L17p</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">RA11412_2537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88836">
        <property type="protein sequence ID" value="BAV88836"/>
        <property type="gene ID" value="RA11412_2537"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2537"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="52" mass="5435" checksum="CBC430B3E8262F11" modified="2018-10-10" version="1">MKGNADSMKYHVPGSRWYANTIAEIWFDSAESAEAAGYAPAGGAAAQKVSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Z6</accession>
    <name>A0A2Z5R2Z6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rpsI</name>
        <name evidence="9" type="ORF">I6I94_09260</name>
        <name evidence="10" type="ORF">NCTC10207_01749</name>
        <name evidence="8" type="ORF">RA11412_2532</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888782.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88831">
        <property type="protein sequence ID" value="BAV88831"/>
        <property type="gene ID" value="RA11412_2532"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2532"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="165" mass="17806" checksum="C9CCAA15671AD2BD" modified="2018-10-10" version="1">MAQNEEQIVVEEELTSYTSESAAPVAAAAQASRPALTVAGAAVGRRKEAVARVRVIPGSGNWTINGRALDSYFPNKLHQQDVNQPFKILELEGAYDVIARINGGGPSGQAGALRLGIARALNEIDRENNRPALKKAGYLTRDARVIERKKAGLKKARKASQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Z8</accession>
    <name>A0A2Z5R2Z8_9MICC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        <location>
            <begin position="849"/>
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        </location>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
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            <end position="174"/>
        </location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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            <begin position="780"/>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="955" mass="96907" checksum="4559F9CB8F471EF0" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R304</accession>
    <name>A0A2Z5R304_9MICC</name>
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        <submittedName>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="38" mass="4177" checksum="AE7566991CBC7D17" modified="2018-10-10" version="1">MRQLVAHLLVLLVVPPVPQVVARLVQLRVQHPVGQTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R336</accession>
    <name>A0A2Z5R336_9MICC</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="VEI24037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88974">
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        <property type="gene ID" value="RA11412_2675"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2675"/>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
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    <dbReference type="Pfam" id="PF07179">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="173"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <sequence length="441" mass="49435" checksum="BF05C2EF593E1869" modified="2018-10-10" version="1">MQEALNNIGSWLLDVVRAEPGWNELILDIKPLAEQTFVRVREFRDDQEFIGTIGPLKEDSPVIEEIRKLQQAAYDDVRGTFFTASIVVAAMNWPNPQFSVGASYKRDIEPESWKGEGGLTAVDVREHLRQFPRARKFVPEWAYERLGGRADRKDLEEFTREGKEEHEVPNSYLVHALDVFKNDVREETLINVVRTLVGGDVLVDATGSTVVPQGQLEIGPESQLRYQVIRHDQNTQALSVFSSSEYILGSPGYDKSREGDELILREPAMKILMDFLSNEDLDLIVIDPGSDHECYIERAQVEWVVGAPRNDGAKMALMNDNMQQLLGSLVAPNSMLLVAVDPNDPMSRPFYAPDENGKPKSMLVFTSPIEVAAIDPKITVRAAHALEVLKFAISDGAKSVQINLFNPSTTLSLKQIRELLDITQEQENMQKEAMSEAAVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R341</accession>
    <name>A0A2Z5R341_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper metallochaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89072">
        <property type="protein sequence ID" value="BAV89072"/>
        <property type="gene ID" value="RA11412_2773"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2773"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PCuAC_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="114"/>
            <end position="210"/>
        </location>
    </feature>
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        <location>
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            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="210" mass="21531" checksum="C60D8B929A37BC94" modified="2018-10-10" version="1">MKASKGSMTGVFGKITNSGDKPVKITSASSTATDTVQLHTTTKGSDGGTKMEQVHEFTIEPGATLELKPGGDHIMLMDMGCSLAAGGATTVTVKTEDGASLEFKPVARDYQGAKEEYKGEGSASATADASASGHDHSHEGHDHEHGGHDHSHSHDGHDHSHEGHDHEHGGSSASGSASAGEHADHDHGEGSHEHSHGAAGASESPLPECK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R347</accession>
    <name>A0A2Z5R347_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose 1,4-beta-cellobiosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89082">
        <property type="protein sequence ID" value="BAV89082"/>
        <property type="gene ID" value="RA11412_2783"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2783"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="102" mass="10665" checksum="9BB97B40B6ED9A68" modified="2018-10-10" version="1">MTMGEGGAWTLTEADGDTITVAADGSWTKTERDGDTVSVQPDGSWTKTEHDGDSVTVKPDGSYNQVEHDGKADKPDTPDVPAKPNAEAANPVSPVQPTKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3A7</accession>
    <name>A0A2Z5R3A7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Naphthoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="4.1.3.36"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89026">
        <property type="protein sequence ID" value="BAV89026"/>
        <property type="gene ID" value="RA11412_2727"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2727"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010198">
        <property type="entry name" value="DHNA-CoA_synthase_MenB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="PTHR43113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV89026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="176" mass="19656" checksum="DCE009DFE350E678" modified="2018-10-10" version="1">MQRLIRTMPKVVIALVSGWAAGGGHSLHVVADLTIASEEYGKFKQTDATVGSFDAGYGSALLARQVGQKFAREIFFLAKEYDAQRMYEMGAVNDVVPHAELENKGLEYAAHIARQSPQAIRMLKYAFNLPDDGMLGQQVFAGEATRMAYMTDEAVEGRDAFLQKRDPDWSNYPYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3D4</accession>
    <name>A0A2Z5R3D4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87529">
        <property type="protein sequence ID" value="BAV87529"/>
        <property type="gene ID" value="RA11412_1230"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1230"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="269" mass="28727" checksum="07FED42D77BAAD35" modified="2018-10-10" version="1">MSVSLGMPVLKPAPQVLAPRRKTRQFKVGTVGIGSESPVSVQSMTTTKTHDIGSTLQQIAELTAAGCDIVRVACPTDKDAEALPIIAKQSNIPVIADIHFQPKYVYAAIKAGCGAVRVNPGNIRKFDDQVKEIAEMASDHGTSIRIGVNAGSLDKRLLEKYGKATPEALVESAVWEASLFEEHGFRDFKISVKHNDPVIMVEAYRQLAASGDWPLHLGVTEAGPAFQGTIKSSVAFGTLLSQGIGDTIRVSLSAPPVEEVKVGTKSLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3D7</accession>
    <name>A0A2Z5R3D7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">rbfA</name>
        <name evidence="4" type="ORF">I6I94_03130</name>
        <name evidence="5" type="ORF">NCTC10207_00650</name>
        <name evidence="3" type="ORF">RA11412_1240</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037233244.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87539">
        <property type="protein sequence ID" value="BAV87539"/>
        <property type="gene ID" value="RA11412_1240"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1240"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI22569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="154" mass="16815" checksum="75E68B90022212EB" modified="2018-10-10" version="1">MADAARAARLADRIKVIVAQALERRVKDPRLGFVTVTDARVTNDLQHATVYYTVYGSEQEQASTKAALESAKGILRSEVGKNITARLTPTLTFVPDEVPVNAYHLEDLLRKTRERDAQLAAAATGAQYAGEADPYKKSADDNEFGEDTTGEDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3F7</accession>
    <name>A0A2Z5R3F7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7 8">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 14" type="primary">recA</name>
        <name evidence="14" type="ORF">I6I94_02995</name>
        <name evidence="15" type="ORF">NCTC10207_00677</name>
        <name evidence="13" type="ORF">RA11412_1270</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="14 18" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87569">
        <property type="protein sequence ID" value="BAV87569"/>
        <property type="gene ID" value="RA11412_1270"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1270"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="11">
        <location>
            <begin position="48"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="12">
        <location>
            <begin position="212"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="78"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV87569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT89595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VEI22596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="369" mass="39328" checksum="4EFC24C758EFD436" modified="2018-10-10" version="1">MAKNNKAESVSRVPEEGRAKAIEAVMAKIDKNYGKGAVMRLGDKETTKTEVIPTGAIALDAALGIGGLPRGRVIEVYGPESSGKTTVALHAVANAQKAGGVAAFIDAEHALDPVYAAKLGVDTDALLVSQPDTGEQALEIMDMLVGSGAIDIIVVDSVAALVPRAEIEGDMGDSHVGLQARLMSQALRKITGRLSATGTTAIFINQLREKIGVFFGSPETTTGGKALKFYASVRIDIRRIETLKDGANPIGNRTRAKIVKNKMAPPFKQAEFDILYGEGISVEGGILDLAVEHDIVKKSGAWFTYEGEQLGQGRENVRKLLKDNPELTEELQYKVLVKLGVIEPEEEETAEEAGAAPEVDPLDEIAEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3H5</accession>
    <name>A0A2Z5R3H5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_1300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87599">
        <property type="protein sequence ID" value="BAV87599"/>
        <property type="gene ID" value="RA11412_1300"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1300"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="PTHR13414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="175" mass="19344" checksum="1D4137EA4F7747B6" modified="2018-10-10" version="1">MSANSSHSGSGAIIAALVANLGIAVLKFVAFILTRSSSMLAEAIHSVADSGNQLLLLVGGKVSQRAADEEHPFGYGRNRYIYAFIVSIIIFALGGLFALYEGYEKWHDPHGITEWQWVPVAVLVGAILLEGNSFRVAVKESRELKGTQGWFRFLRTSKTQSFQCFCWRMQAPFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3L3</accession>
    <name>A0A2Z5R3L3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87639">
        <property type="protein sequence ID" value="BAV87639"/>
        <property type="gene ID" value="RA11412_1340"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1340"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="250" mass="27527" checksum="44F959C953475161" modified="2018-10-10" version="1">MDHFDFYDENGVRLQKLMAQAGVASRRVCEQMITEGRVTVNGEAVTELGVRVNPADVVVQVDGMTVQTNDKLVYMAFNKPAGVVSTMEDPDGRPCIKDFLRSSMTERVFHVGRLDVETEGLLLLTNDGELANRLTHPSYEVPKTYLVQVRGPVESGVGAQLKKGVRLEDGVSRVDSFKLVDSAPGHVLIEVSIHSGKNRIVRRLFEAVGYPVEKLVRVEMGPVRIGSQKQGTVRNLSKVEIGHLLASVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3M8</accession>
    <name>A0A2Z5R3M8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTH-type transcriptional regulator tnrA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tnrA</name>
        <name evidence="3" type="ORF">I6I94_02585</name>
        <name evidence="4" type="ORF">NCTC10207_00771</name>
        <name evidence="2" type="ORF">RA11412_1370</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887865.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87669">
        <property type="protein sequence ID" value="BAV87669"/>
        <property type="gene ID" value="RA11412_1370"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1370"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="49"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI22686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="256" mass="28836" checksum="6078916BE629CBA9" modified="2018-10-10" version="1">MSSLIDENLARAEALVESVGRGENSRDPRDIKSRTIGQVLSQLDLDFPGISASKIRFLEERGLVYPKRTDTGYRKYSQTDIERLRYILTMQRDYYMPLKVIRQHLDDLEAGRAINAIPAPVSDEVLDQVLGSSDNASRKYTLRELAEYSGASTELIDDLVEYGLIEAKDGEYTEYDVLTARTSAELTQHGIQPRHLRSFKSAAEREISLVEIAVAPLASRRDPSSQSQAQERADKIRKLCLQLHATLVESAMPSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R491</accession>
    <name>A0A2Z5R491_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA helicase RecG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88389">
        <property type="protein sequence ID" value="BAV88389"/>
        <property type="gene ID" value="RA11412_2090"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2090"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="221" mass="23706" checksum="F753D2F317B564BD" modified="2018-10-10" version="1">MLADAEVAHNPLLTVQDLAAYARHETTLAALQETVERRRSPQYQAALASLTKSLGEAAGAMDPAELYELVDIALEARPQHAERNPVAPAPQAKAVKTRARQKNNKQKGGEKPVAARQSGSSGVPDTAARRVRGKEQQADSRAAEQGAATAKRKPAASETKRKTSGNTPVGTPTAEAQKTIKGNKNTENGQAKKRALNRYNTEDRIENAPLKITFLTRPCGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4X7</accession>
    <name>A0A2Z5R4X7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0336 protein RA11412_2660</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0336 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88959">
        <property type="protein sequence ID" value="BAV88959"/>
        <property type="gene ID" value="RA11412_2660"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2660"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="153" mass="16414" checksum="FED479571E9B9486" modified="2018-10-10" version="1">MGMSINPDIVGRVYPAEGTYAVGREKIREFARAVHAENPLHHDVEAARAAGYADLIAPPTFAIILSQAADAALIGDKSAGIDFSRVVHADQRFTHHRPIVAGDELRTEVHVDSVRVMGAGAMLTTREEITDADGKPVTTCISSLLVRADEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVB7</accession>
    <name>A0A2Z5QVB7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="8">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="8">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pckG</name>
        <name evidence="11" type="ORF">RA11412_0036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86335">
        <property type="protein sequence ID" value="BAV86335"/>
        <property type="gene ID" value="RA11412_0036"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0036"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <location>
            <begin position="29"/>
            <end position="249"/>
        </location>
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        <ligand>
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    </evidence>
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        <source>
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    <sequence length="420" mass="46130" checksum="661D9523799F2F55" modified="2018-10-10" version="1">MTDISRGALSAELEKDLQNAPTTHAGLLEWVREVAALTEPDRIYWVDGSEEEYNRLAQELVDAGTFVRLSDHEFPNSYAAFSDPDDVARVEERTFICSQTEEGAGPTNNWRDPVEMKQTLTGLFKGSMRGRTMYVIPFVMGSLKAKNPKMAVEITDSAYVVCSMRIMATIGKDVLAKLDETQGFFVKALHSVGAPLEPGQADVPWPCNPEKYIVQFPETREIWSFGSGYGGNALLGKKCYALRIASVIGHDEGWMAEHMLILKVTNPEGVTRYISAAFPSACGKTNFAMMDPTIDGWKAEMVGDDIAWIEFDENHQARVVNPEAGLFGVAPGTGYSTNPNAMKAISKGNTIFTNVALTDDGSVWWEGKTDEAPAHLTDWTGKDWTPESGRPAAHPNSRFCTPASQVDMLAPSTTILRACR</sequence>
</entry>
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    <accession>A0A2Z5QVN0</accession>
    <name>A0A2Z5QVN0_9MICC</name>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">JCM 11412</strain>
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    </reference>
    <dbReference type="EMBL" id="AP017895">
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <name>A0A2Z5QVR3_9MICC</name>
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        <submittedName>
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        </submittedName>
    </protein>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 8">JCM 11412</strain>
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    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
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        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="121"/>
            <end position="365"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="366" mass="36932" checksum="9E70EE2ED45131F0" modified="2018-10-10" version="1">MNNEYTPSNGLTASPFAPAARGTAPSTTYAYDGAHHSTAHTAQPNAPQHAPAARPGPQYAPAPQAPHAGPPAPTQPPHASPAAPTSAAGAVPARPAPDAPVPTAAGPAASTSAPGTAAPVISARSVTKTYGPNTVLRGVSLDIYPGESVAIMGPSGSGKTTLLHALAGIITMDSGSVHITTPHPGTGPNTVDLSSLTEKQRTALRAGSFGFIFQQGLLVPELTTEENVALAAMLAGGGRAQARVAAVDLLTKLGLGDKLQCRIGELSGGQAQRVAIARSQVTGAPITFADEPTGALDTTTAHEVMALLLALIPQQGKTLVIVTHDPQVAQRCSRIIHLRDGQIVEEARPADQPAAHATAPGSTETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVZ6</accession>
    <name>A0A2Z5QVZ6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86561">
        <property type="protein sequence ID" value="BAV86561"/>
        <property type="gene ID" value="RA11412_0262"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0262"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="5046" checksum="1F76817A3523E131" modified="2018-10-10" version="1">MHLKEREQKIFIHTGFLILILKHVSSAPGKANKTLRDNSPSFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW15</accession>
    <name>A0A2Z5QW15_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_06945</name>
        <name evidence="3" type="ORF">RA11412_0282</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86581">
        <property type="protein sequence ID" value="BAV86581"/>
        <property type="gene ID" value="RA11412_0282"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0282"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="134" mass="13773" checksum="801DFB0A555107F3" modified="2018-10-10" version="1">MAEDRPRGLKAQVKGPLIIAAALALAAFFAVFVFATGGTHNKPNIGLALGVGGAVFIVTLVVCATLILVDRPNDPSLGQGTGINRSSAELYAQAKAKREAAEREKARAEGNSQAAGTKAETAENDAEPPKTTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW27</accession>
    <name>A0A2Z5QW27_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_06905</name>
        <name evidence="7" type="ORF">RA11412_0292</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86591">
        <property type="protein sequence ID" value="BAV86591"/>
        <property type="gene ID" value="RA11412_0292"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0292"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="32"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV86591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="252" mass="27273" checksum="2CE71DD6B589AA21" modified="2018-10-10" version="1">MTSALVSSRISTVRATVELIRWSLIRNAINAPLFAVVQVLLAFALLYGISVFMPHLDRNSAEYLASGTVTVTLISMGCVIAPQIIVTTKTNGMFDYQRSLPVPRLAILAADILVWAVLAIPGIIAGGAAAKLKFGFDVNLSIGAIAVVFALQVVMAVLGFMLAYWIPAAFLTIVTQTITFMVILFAPINYPPERLPEWYAHVQQFLPFAPAANLVRATLFNIGPIQILDVIVVGFWGLLGCASALWALARRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW78</accession>
    <name>A0A2Z5QW78_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86658">
        <property type="protein sequence ID" value="BAV86658"/>
        <property type="gene ID" value="RA11412_0359"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0359"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="62" mass="6124" checksum="C4E42C2661427038" modified="2018-10-10" version="1">MPANNPAAASVAQSESQATVAKSASNLANTGFSATPVATAAGLFATGVALTYAASRKRRQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW90</accession>
    <name>A0A2Z5QW90_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Anchored repeat-type ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Manganese ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_06585</name>
        <name evidence="8" type="ORF">RA11412_0378</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86677">
        <property type="protein sequence ID" value="BAV86677"/>
        <property type="gene ID" value="RA11412_0378"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0378"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022392">
        <property type="entry name" value="Anch_rpt-typ_ABC_trnsprt_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03770">
        <property type="entry name" value="anch_rpt_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="290" mass="30733" checksum="7669484176541BCC" modified="2018-10-10" version="1">MITPLDFLFDLFNPSLAFLPRALAAVTLASLVTGVVGCHVMMRGMVFIGDAVAHSVFPGLAVAFVIGGNLVFGGLIAGVITAVLVAIFSQNQKLREDSVIGIFFAGSFALGIVIISLAPGYSGSIQDFLFGSIVGVSRGDIAQAAAMSAGILLLLWLFHRQLVTVSLDRESARALGLPVLLLDILLYVLVTVSVVISLQTLGNVLVLALIVVPASASRLACRRLGTMMLFSPVFGVLCSTAGLYFSWAFNLPTGGTIVLTMVAAFVLVWAFTWMHQRVRRIPETAHSLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW99</accession>
    <name>A0A2Z5QW99_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86656">
        <property type="protein sequence ID" value="BAV86656"/>
        <property type="gene ID" value="RA11412_0357"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0357"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4591" checksum="9A5A640CD454E06B" modified="2018-10-10" version="1">MAVFFPAMNFLQHPDVFADNPERQAADVPVHILEGSAHNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWC6</accession>
    <name>A0A2Z5QWC6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADA regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_0409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86708">
        <property type="protein sequence ID" value="BAV86708"/>
        <property type="gene ID" value="RA11412_0409"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0409"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="6">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV86708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="80" mass="8546" checksum="9AA6142921FCE8EE" modified="2018-10-10" version="1">MQVWRALLNIPQGAVQSYGSVAESIGRPRAARAVGTAVGHNPVALIIPCHRVIRESGVIGDYRWGRGRKMALLAQELGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWF0</accession>
    <name>A0A2Z5QWF0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86716">
        <property type="protein sequence ID" value="BAV86716"/>
        <property type="gene ID" value="RA11412_0417"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0417"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="53" mass="5679" checksum="96261116D01144BE" modified="2018-10-10" version="1">MSQKSDVQPNNTAFGRGSYRESVRIADILRTESVGGSILLIATVLAIIFANTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWK3</accession>
    <name>A0A2Z5QWK3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86713">
        <property type="protein sequence ID" value="BAV86713"/>
        <property type="gene ID" value="RA11412_0414"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0414"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="56" mass="6015" checksum="F9C373F1E0E5B740" modified="2018-10-10" version="1">MYGVNVKDSAMLGLGMQKYVHAWANPEAEGTKSSVVGERRLLARGVYRNICGGACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWL1</accession>
    <name>A0A2Z5QWL1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alanine:cation symporter family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Amino-acid carrier protein AlsT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I6I94_06400</name>
        <name evidence="9" type="ORF">RA11412_0424</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037233955.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86723">
        <property type="protein sequence ID" value="BAV86723"/>
        <property type="gene ID" value="RA11412_0424"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="516" mass="55509" checksum="F3FB9B2CF5EF3668" modified="2018-10-10" version="1"> </sequence>
</entry>
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    <accession>A0A2Z5QWL8</accession>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="EMBL" id="BAV86770.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 4">JCM 11412</strain>
        </source>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="RA11412_0434"/>
    </dbReference>
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    </dbReference>
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    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A2Z5QWQ9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0568</name>
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    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86867">
        <property type="protein sequence ID" value="BAV86867"/>
        <property type="gene ID" value="RA11412_0568"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0568"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="39" mass="4409" checksum="737862505CC7415D" modified="2018-10-10" version="1">MMSVRGSCGELSWAMQGIPSGRQKLETERVIFYILSVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWT7</accession>
    <name>A0A2Z5QWT7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="BAV86888">
        <property type="protein sequence ID" value="BAV86888"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="148" mass="15750" checksum="93429CACE89B6708" modified="2018-10-10" version="1">MLSKLKGKRPDALIVMLITAVILAIFIPARGDFAAWFSTGTKFAVALLFYLYGARLSTSEALKGLAHWRLHAMILTCTFVLFPLFGLALYPLRFVLGDGLYLGLLFLTLVPSTVQASIAFTSIAGGNVAAAIVSASLSSIVGCLPPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWY7</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">RA11412_0656</name>
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        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="RA11412_0656"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="214" mass="23343" checksum="A190042D7915532F" modified="2018-10-10" version="1">MYINHLYYHSSSAITHTLTHILANAVKHADVRAYLFFSADREAEFEETAARISGKVVWVHSVATGPMGFLAERAFIGLIEFNVPAGGAGAVSAFFEESGIAEKDGQVLLVKDPASPENLRDILLREYTPHDERANTNFPSVDALMNAGTALLYYRDLAGAAYDSDSGETLSCCEVFVDAEWEHLVPEPPQDATTNEGSFDTAAGEVKFTVIEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX11</accession>
    <name>A0A2Z5QX11_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_0669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">JCM 11412</strain>
        </source>
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    <dbReference type="EC" id="2.3.1.8" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86968">
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    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0669"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P_AcTrfase"/>
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        <property type="entry name" value="P_AcTrfase_dom1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00651">
        <property type="entry name" value="pta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DRTGG" evidence="5">
        <location>
            <begin position="214"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="PTA_PTB" evidence="4">
        <location>
            <begin position="374"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="670" mass="72089" checksum="6B9254FC4A7E84BF" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX34</accession>
    <name>A0A2Z5QX34_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell filamentation protein</fullName>
        </submittedName>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_05230</name>
        <name evidence="3" type="ORF">RA11412_0706</name>
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    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87005">
        <property type="protein sequence ID" value="BAV87005"/>
        <property type="gene ID" value="RA11412_0706"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0706"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
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    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
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    </dbReference>
    <dbReference type="Pfam" id="PF02661">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="58"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="273" mass="31208" checksum="E4F4FFD8AB3AD435" modified="2018-10-10" version="1">MTVFDSWESYFYPPPNNETLRNLKGILNPRDLAAYEYAATDLRNRQLKTDPSLIEHTYDADHVRAIHRYLFQDVYEWAGDYRTQNMFKGGRFVPFASVNGGEIDRYLNTTHHIVTTTDWAQLDRDEFSHAAAAVFANLNQAHPFREGNGRTSRVFMDHVAQNSKFDLDYSRVSPKDWNMASMLSGPDLGKYEVVPGSLVPVFQAIATRREPEVSAPSETSTVMRQMRSKIGEVKKGYAPSPQGQPQKNQQRQTPQQPYRPKRGYGDRRPGMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX58</accession>
    <name>A0A2Z5QX58_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86923">
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        <property type="gene ID" value="RA11412_0624"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0624"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5016446853" evidence="1">
        <location>
            <begin position="43"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="49" mass="4878" checksum="115634A0DF2F73FB" modified="2018-10-10" version="1">MVTIMIVNSTMRSSAHSSVVIKAVLAVAVILGRAVGAGTANAYTAGVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXB4</accession>
    <name>A0A2Z5QXB4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PqqD family peptide modification chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_04915</name>
        <name evidence="1" type="ORF">RA11412_0779</name>
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    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87078">
        <property type="protein sequence ID" value="BAV87078"/>
        <property type="gene ID" value="RA11412_0779"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0779"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="103" mass="11761" checksum="282DC0712D7FA183" modified="2018-10-10" version="1">MKTMYKRYASLPERFCIADGVKISGTESGIVVFVPTRSAYFQGNSTTEHILDLVEQGRRNSEIIDSFIRQYTQSDPDEIREDLEGTLRELWTMGVLEKGEDHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXC0</accession>
    <name>A0A2Z5QXC0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86874">
        <property type="protein sequence ID" value="BAV86874"/>
        <property type="gene ID" value="RA11412_0575"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0575"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="59" mass="6251" checksum="51599AE718490493" modified="2018-10-10" version="1">MAVSAFLKQQHRPAAAFVKPAAAVLGIGAVGAAAAYLIGPCCLNSYIRLRVMRRQPTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXF3</accession>
    <name>A0A2Z5QXF3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I6I94_05140</name>
        <name evidence="16" type="ORF">RA11412_0724</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87023">
        <property type="protein sequence ID" value="BAV87023"/>
        <property type="gene ID" value="RA11412_0724"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0724"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="15">
        <location>
            <begin position="66"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAV87023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QQT89976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="334" mass="36747" checksum="76E833C01E299B82" modified="2018-10-10" version="1">MFYPSSMTSSPRTPHPRAVSTAPHVSCAQTEQLHQLVGDWFIANARDLPWRRAECSAWGVMVSEFMLQQTPVKRVLPVWEEWMRRWPTPKDLAAEESAEAVRAWGRLGYPRRAQRLHAAAQAIVLEHHGDVPGTYEQLLALPGVGSYTAAAITSFAFGRRATVIDTNIRRVHARAISGKGLPNKSLNAAETRLAEALMPTDEQASCLWNAATMELGALVCTAKSPTCSICPIRHLCAWVAAGKPEAEYTPQGQSWHGTDRQLRGAMMAVLREAHHPIPKELITNFSPDIVAPKNLSTVVKSLRTLGSSQEQIQRCYEGLLADGLASEKDDLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXG7</accession>
    <name>A0A2Z5QXG7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">folB</name>
        <name evidence="4" type="ORF">I6I94_05200</name>
        <name evidence="3" type="ORF">RA11412_0711</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHNA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87010">
        <property type="protein sequence ID" value="BAV87010"/>
        <property type="gene ID" value="RA11412_0711"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0711"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="2">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="144" mass="15436" checksum="D12D8399BCF499D9" modified="2018-10-10" version="1">MPNQAHAYASCDRITLTGVAAVGFHGALDFEKREGQPFIVDTVLYTDFTQAAATDDLAQTTNYAEVAEIIRTHIVGESLDLIETLAVRIAQNVLDECAYVHALEVTVNKPKAPIEVTFGNVAVTVFREREGTQSQGGKGAGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXM1</accession>
    <name>A0A2Z5QXM1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Manganese ABC transporter SitD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_0685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86984">
        <property type="protein sequence ID" value="BAV86984"/>
        <property type="gene ID" value="RA11412_0685"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0685"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="390" mass="41213" checksum="E23388C3107C93F6" modified="2018-10-10" version="1">MAVALIGAVQRSGRVREDAAIGIVFTTLFAFGLILISVTPSNTDLNHILFGNVLGVSWLDVWQVLALAAVVGAVLLVKRRDFVLYAFDPGFAHAIGLRPRLLGGMLLVMLALTSVVALQIVGVVLVVAMLVIPGSTARLLTDRFSMMLAISVGVSLLGTLIGLYSSYYMDVSPGGAVVLTQGCCSCWRTYSPRITGCWDGPAPPIVRSRALPYTGSRRASLGGSSGAGDEKVGCGSCPQWHGGLRRGSRGLGGCSACIRWCDNTHINGLGERGAFFDRQVRTGSETMLGQVAQQLGSLSLMRSSTTVSPGSHWLSGTVCGNEMRPEASGMGSPCGSRLGCPSTVSMRSIMKSETACSSTSASSCTRSQVYPRVSTRKVSIRRWRRIIATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXS4</accession>
    <name>A0A2Z5QXS4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport ATP-binding protein OppD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_04685</name>
        <name evidence="6" type="ORF">RA11412_0827</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87126">
        <property type="protein sequence ID" value="BAV87126"/>
        <property type="gene ID" value="RA11412_0827"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0827"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="364"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="408"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="705" mass="76796" checksum="C20C7C3D7C18FDB4" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY29</accession>
    <name>A0A2Z5QY29_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Virulence protein RhuM/Fic/DOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_04290</name>
        <name evidence="2" type="ORF">RA11412_0937</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87236">
        <property type="protein sequence ID" value="BAV87236"/>
        <property type="gene ID" value="RA11412_0937"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0937"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011204">
        <property type="entry name" value="Virulence_RhuM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13310">
        <property type="entry name" value="Virulence_RhuM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="180"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="321" mass="35641" checksum="C1C02878ED4CBC7F" modified="2018-10-10" version="1">MNEFNNSIIIYQPNTDQPAIDVQIEGETVWLSQRQMSVLFNTSSDNVGLHLKNIYAEGELLEEATTEDFSVVRQEGTRQVRRSVRHYNLDAIISVGYRVKSATATQFRIWATKRLREYLVQGYSINQQRLEQLGQIVEVMARADNHLVAGTGEVLAAYLPSLQALRDYDEGTLSASESTGNAPVWQLTHAEAQAIIARARSEFPQDRLFGIENGDKLKSVVATIYQSFAGEDLYPTTEQKAANLLYLMVKDHPLVDGNKRSAAALFIEFLAQNNLLFSADGTPLVSNNALAAMTLMVAMSSPKEKDLMVALVERLISPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY54</accession>
    <name>A0A2Z5QY54_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoribosylaminoimidazole carboxylase ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Purine metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87372">
        <property type="protein sequence ID" value="BAV87372"/>
        <property type="gene ID" value="RA11412_1073"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1073"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="91"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="300" mass="32376" checksum="5C98B8513AF3E4D8" modified="2018-10-10" version="1">MMAPAATNLGLNLHILAETPQVGAVAAVRTAVVGDYKNLDTLREFAAGKDVITFDHEHVPTELLHTLIAEGVNVQPRPEALQYAQDKLLMRAAIERLGLPNPRWAKVSTLTELLEFGDATGWPVVLKTPRGGYDGKGVLVLESAGDARERAASWFDQLESRTDFSSLLAEEKVPFTRELSALVARRESGQVIPWPVAETIQIHSVCDEVISPAPNLEAQVAAAASEAAVHIATELGVTGVMAVELFEVPGSASGFYINELAMRPHNTGIGPKTVQSPASLSSTCVRCLTYRWVMHLPLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY74</accession>
    <name>A0A2Z5QY74_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03585</name>
        <name evidence="2" type="ORF">RA11412_1118</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87417">
        <property type="protein sequence ID" value="BAV87417"/>
        <property type="gene ID" value="RA11412_1118"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1118"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="231"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="393" mass="43787" checksum="894B485EC9723BC7" modified="2018-10-10" version="1">MFAHAHHLLSGAQKTAKKCLPFWRVQATEEIAIAHDYLTQRGGAERVVLAMHKAFPEATIYTTLYDPEGTFPEFKDAKIVTSGINRIGLFRHKHRFALPLLPFASSLLKVPARKAIISTTGWAHGFRYAGQSFVYCHSPARWLYLSDQYLGKKKDGVAGIALRTLRPALTRWDQRAAAKSENYVGNSTIIRERIQNVYGKEDVPIFFPPHSVDMDSPAEPIPGLEKFMADGDYFLIVSRLLPYKNIEHAVEAFTRMGKKLLIIGRGPEKDSLLKHAGPTVRIASDLPDAQLCYAYRNCVALLAISHEDFGITPLEAGASGKPVIAFRAGGFLDTVVEGRTGVFIDEPTPELIESAVSSFDPAQWDPQQIRAHVEKFSEERFIAQLHEYVAQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY84</accession>
    <name>A0A2Z5QY84_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87427">
        <property type="protein sequence ID" value="BAV87427"/>
        <property type="gene ID" value="RA11412_1128"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1128"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="2"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="189" mass="20274" checksum="4073CA58837904F6" modified="2018-10-10" version="1">MHVSTDYVFDGTLPVGQEYSVEHPISPLSVYGASKAAGESAATAWRKHYLLRTSWVVGEGKNFVATMASLAERGVDPVVVADQWGRPTFTQDLAGAALHLLFTGAPYGTYHVSNSGEVITWADLARAVYTGTGHDAARVSDTTTAEYFANAQVFAPRPANSALDLSKLIAAGFTPRDHRDALAEYLKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY93</accession>
    <name>A0A2Z5QY93_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_04410</name>
        <name evidence="3" type="ORF">RA11412_0905</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87204">
        <property type="protein sequence ID" value="BAV87204"/>
        <property type="gene ID" value="RA11412_0905"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0905"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340097" evidence="2">
        <location>
            <begin position="32"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="511" mass="52288" checksum="40C6CC0E165E368A" modified="2018-10-10" version="1">MQNKLSRRTLVTGAAWAAPVVMASSSIPAFATSPVEPCVADKTFNSQHYAKPPRGNTREKVYDHWTVPADVHQIKFYVRGAAGGSTHEDQYGGGFGGAGAEVAGYLDVTPGETLTFVTGAAGTANFDGTPAEGGKGFGDGGSSAALPTDSQVGIRNNQAQFILDKLKPAKIQYGGSGGGASAIVRMESDGFTIKEVIAIAGGGGGAGVTVQHNTNDYPRTKEGSYKTATLTIGEQGSGGMQVQQSPQSVEGQTVTVVQHVDSMDGGDASTSLENYPDYEQTVYGGKGSGTAEGGSNGTGGAGGEAPAADQDRVTQEYLSYAKFDQPTGAYINYSDDGNIFASAFEGAEGNSTSNPTEPVNGADGVSAWGAVQTYDGHYADGYDNANYYVYAVSGGGGGGYGGGGSGSVIGQGVRVTAPDQEQDIEGSSNKFRYSGAFASAGAGGAGGSYLAPGIEMWDSNGKKFWAHNNRTFGTNDTNGHGRIKVIWCDPSGSHKDYPDDPGVPAPVVPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYA0</accession>
    <name>A0A2Z5QYA0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TadE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87214">
        <property type="protein sequence ID" value="BAV87214"/>
        <property type="gene ID" value="RA11412_0915"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0915"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="152" mass="15565" checksum="A53B7AC14C7820D3" modified="2018-10-10" version="1">MRIYSPWRVREPSSAPGPSKIRSADPSDAEHGAVTAEFAVVLPGVTLVLALCLGAVATGAAQVRLEDAARAAARAAARGDTEASIHTAVSQTDRDAAVSIAREGNTVRVSAERKAPGVIGATTGWTLRAQATASVEGSEGLQDTGEAAHHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYA4</accession>
    <name>A0A2Z5QYA4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside triphosphate hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03910</name>
        <name evidence="2" type="ORF">RA11412_1034</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87333">
        <property type="protein sequence ID" value="BAV87333"/>
        <property type="gene ID" value="RA11412_1034"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1034"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="44"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="234" mass="26000" checksum="5A4B1B4028440D6A" modified="2018-10-10" version="1">MNEDKASEKDVAEVAARAGRAFERLVHTMATLRAPGGCPWDTEQTHQSLIRFLIEESYEVVEAVEAPEGTNLQLLREELGDVLLQVLFHADIAAAEPGGFTIEQVIEGLDTKLHDRHPNVFGDSSGESRMTAAEQQVFWDELKKKEKSDRGPLDGIPPHLPALALAAKAIAKARKADIVLPPEPTSLDDDLPFTYSEEDFGELLFSLVCRARQNGLDAERALRTYTRKFIEYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYC4</accession>
    <name>A0A2Z5QYC4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AI-2E family transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_03850</name>
        <name evidence="8" type="ORF">RA11412_1047</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87346">
        <property type="protein sequence ID" value="BAV87346"/>
        <property type="gene ID" value="RA11412_1047"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1047"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="441" mass="46448" checksum="0EAAC4024B382DB1" modified="2018-10-10" version="1">MGQTPDTNDTAPTKNTTVPFALETAAAWSWRLLVVAGAGWVLWQGLAKVSLLVISLMVAALLAALLSPAVYALRKRGVRAGAATAIAEIGMIVGLLALVALTGQQLAQGFVSLWSKALEGYNELVHWLDNMGYSLGAEQLNQLLEQGRKLASENPSSIVRGVSEVGSTAAEVATGTLITLFTLVFFLMEGERIWLFIVGLLPRRARDAVNGAGRAGWKSLGAYVRVQILVAAIDAVGIGIGAAILGVPLAIPLGVLVFLGSFIPVIGALLSGAVAVLLALVALGPVQALIMIGIVLLVQQLESHILQPLIMGKAVSLHPLAVIFAVAGGSMIFGATGALFAVPVLAVVNSVVRYLASRGWENDPQLRTEEFLFPHEVRRREAAKRRRGAVEDAAERVRGRARTAAGRDEEPAEEPALAEPASAENTDSPQGKKPSRKQGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYD6</accession>
    <name>A0A2Z5QYD6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87254">
        <property type="protein sequence ID" value="BAV87254"/>
        <property type="gene ID" value="RA11412_0955"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0955"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="4173" checksum="907411F8D69D04BB" modified="2018-10-10" version="1">MRWRQNSCRGPVTGAVAEPSPNTFIKSYGENIQKYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYJ3</accession>
    <name>A0A2Z5QYJ3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_03590</name>
        <name evidence="4" type="ORF">RA11412_1117</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87416">
        <property type="protein sequence ID" value="BAV87416"/>
        <property type="gene ID" value="RA11412_1117"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1117"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_transf_7C" evidence="3">
        <location>
            <begin position="168"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="326" mass="36008" checksum="5046D526D580E69B" modified="2018-10-10" version="1">MTHLTHHEAHSHNADHYYKAAVVIPSRGGAHLLHYPLEALRAQTEKDFQVIVVLDGDIDNSEAVLKKYAAEGGLNLSTIIFPENRGRVAALNAGHRAANAKVLIRCDDDLQPDEHYVANHLRLHQEYDGVIGTLNNVFPETPYSLVYGNYRDKKFKQGALSVPPHERWHYWNGNSSVSAEFFHKVGGFDPAYRLYGWEDVDMGKMIADAAGKILISSEVEAKHHAEATTTSVRALRALHSGAARSIFVRKHGEQAHTAPNPGGVWGAAVKTLALFTTERTIKTVGDASDRILLKLPVKLAEKIVALQVEAASYAGVKYPRRAQKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYK4</accession>
    <name>A0A2Z5QYK4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidyl-tRNA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87433">
        <property type="protein sequence ID" value="BAV87433"/>
        <property type="gene ID" value="RA11412_1134"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1134"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="59" mass="6366" checksum="098E0C1BD011C7C9" modified="2018-10-10" version="1">MRAGIGRPPGRMNTADFVLKPFSTAEAKNLPFLISNAADAVRMLVEKGLVAAQQHYHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYL9</accession>
    <name>A0A2Z5QYL9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="15">2.7.8.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pgsA</name>
        <name evidence="15" type="ORF">I6I94_03015</name>
        <name evidence="14" type="ORF">RA11412_1266</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="15"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87565">
        <property type="protein sequence ID" value="BAV87565"/>
        <property type="gene ID" value="RA11412_1266"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1266"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV87565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QQT89599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="205" mass="22261" checksum="324A46DBC07BEA81" modified="2018-10-10" version="1">MSEQAGGAAPTASNWNLPNALTVVRIVMVPFFVVALIAGGVYGADSLGARWAALALFVAAMITDWADGYLARSRQLITSFGKIADPIADKLLTGAAFITLSWLGELWWWVTAVILVREWGITVMRLFVIKYGVMAASKGGKVKTVLQTVALVVMLVPLGLWGTAWLIPGWALMAAVTAITVWTGLVYVRDARELRKNWLAQQNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYM8</accession>
    <name>A0A2Z5QYM8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Maltose O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_03685</name>
        <name evidence="1" type="ORF">RA11412_1092</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87391">
        <property type="protein sequence ID" value="BAV87391"/>
        <property type="gene ID" value="RA11412_1092"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1092"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="176" mass="19044" checksum="4300D01D37270E45" modified="2018-10-10" version="1">MIQKLKDLKYRLHLMQRERTNAQKRRELTKNGIIFGAGTYCDPSSTIMPKVMMGTNCFVNKETLVGAHTTLGDNVFLGPRVTIFADTHEIGSAAQRAGANITRPVHIKNGTWVGQNAVITAGVTIGKGYVIAAGAVVVHDCAPHGVYAGVPARRIRDLNAEGNSYPVTEQVEGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYQ2</accession>
    <name>A0A2Z5QYQ2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rplT</name>
        <name evidence="9" type="ORF">I6I94_02870</name>
        <name evidence="10" type="ORF">NCTC10207_00704</name>
        <name evidence="8" type="ORF">RA11412_1298</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888986.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87597">
        <property type="protein sequence ID" value="BAV87597"/>
        <property type="gene ID" value="RA11412_1298"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1298"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VEI22623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="127" mass="14538" checksum="7275CFCF83F38C55" modified="2018-10-10" version="1">MARVKRAVNAHKKRRTILDRASGYRGQRSRLYRKAKEQVTHSLVYSYDHRRKKKGDFRRLWIQRINAASRAQGLTYNRFIQGLKAAGVEVDRRMLAELAVNDTAAFNALVEIAKNNLPEDTSAPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYR3</accession>
    <name>A0A2Z5QYR3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87607">
        <property type="protein sequence ID" value="BAV87607"/>
        <property type="gene ID" value="RA11412_1308"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1308"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="45" mass="5245" checksum="E6D835DBB519EE67" modified="2018-10-10" version="1">MGARYQDGIRALRGQRCFDNRGLNYWVLQDFIGHGKGEELRTKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYX7</accession>
    <name>A0A2Z5QYX7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-inositol 3-phosphate glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87510">
        <property type="protein sequence ID" value="BAV87510"/>
        <property type="gene ID" value="RA11412_1211"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1211"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="18"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="241" mass="26630" checksum="049D37124A827AA4" modified="2018-10-10" version="1">MKQAHTILIGAETYPPDINGAAQFGHRLATAMLGRGHEVHVVAASPMRGPSYRTTVEGGIVEHRLRSHLPPTHDTNRICIPWEIHFEVGHILDEVKPDVVHVQCHYIIGRALITQAHKRGIRVIATNHFMPANLDPFLPVPTPIKRVISKATWIDMRRCFSRAAVVTTPTQIGADAMRDLGGFTRPVMPVSNGIEIGDYELAEGATIDKAPVNFASPSWGALPKKKILMCSLRRSLYCRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYY2</accession>
    <name>A0A2Z5QYY2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87685">
        <property type="protein sequence ID" value="BAV87685"/>
        <property type="gene ID" value="RA11412_1386"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1386"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMS_C" evidence="1">
        <location>
            <begin position="81"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="260" mass="28585" checksum="FADEFA25898BD8BA" modified="2018-10-10" version="1">MGGATHRVQEFLDPMPVNKLWGVGARSATLLNEYGIYTVAQLREFDAQWLCGRFGNAAGNHLYALARGIDHRPVVTERVEKSMGAEHTFAADTRCVADIERAVQGIALRLGRRLRAAGKTAGALTIKYRYEGFETHTKSIPLTEPVDSGMQIYRIACAALRAMGLLIKSCDGQKEQASRALRLIGVRAERLQQCASGVQQTLFALDPQEGDGAEKADWGRVERALDGIHTRFSAEAVRPASLMGYTAGRTHMHRVQHRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZB1</accession>
    <name>A0A2Z5QZB1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87835">
        <property type="protein sequence ID" value="BAV87835"/>
        <property type="gene ID" value="RA11412_1536"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1536"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015315">
        <property type="entry name" value="DUF1963"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035948">
        <property type="entry name" value="YwqG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09234">
        <property type="entry name" value="DUF1963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103032">
        <property type="entry name" value="SSF103032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="97" mass="10156" checksum="F24EA5348013E85C" modified="2018-10-10" version="1">MSDIVEKAAALVEELYAENPLPAIGIKPSEAAEPLPVTVSKFGGVPYLPAGVEAPTDSDGIPMGMIAQINCAELPENPIYPPTGMVQFWVSTNSGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZE7</accession>
    <name>A0A2Z5QZE7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87828">
        <property type="protein sequence ID" value="BAV87828"/>
        <property type="gene ID" value="RA11412_1529"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1529"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="64" mass="7327" checksum="0FA68F43E561E0EA" modified="2018-10-10" version="1">MPFARTPRWFRSYKKYPPLVVVAKGAYVDSIKASSCGALGDDYEAKNQLHLLLLHPSMFARWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZH4</accession>
    <name>A0A2Z5QZH4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87872">
        <property type="protein sequence ID" value="BAV87872"/>
        <property type="gene ID" value="RA11412_1573"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1573"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010179">
        <property type="entry name" value="CRISPR-assoc_prot_Cse3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08798">
        <property type="entry name" value="CRISPR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="91" mass="10030" checksum="3DEB74375E596773" modified="2018-10-10" version="1">MRERASQWGFEIIPAEGQELEDAPTVTGRHDLSFSRRDTGGHVGRVTLRKAQFDGALRITNVEQFREALVNGMGRGKAYGMGLMTLAPLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZM1</accession>
    <name>A0A2Z5QZM1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 6" type="primary">acpP</name>
        <name evidence="5" type="ORF">I6I94_01655</name>
        <name evidence="6" type="ORF">NCTC10207_00959</name>
        <name evidence="4" type="ORF">RA11412_1623</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887911.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87922">
        <property type="protein sequence ID" value="BAV87922"/>
        <property type="gene ID" value="RA11412_1623"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1623"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VEI22866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="80" mass="8833" checksum="F4C021B2D9D84C50" modified="2018-10-10" version="1">MANKEEILAGLAEIVNEETGVEVEDVQLDKSFTEDLDIDSISMMTIVVNAEEKFEVTIPDEEVKNLKTVGDAVEFIENAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZW1</accession>
    <name>A0A2Z5QZW1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_02060</name>
        <name evidence="3" type="ORF">RA11412_1501</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87800">
        <property type="protein sequence ID" value="BAV87800"/>
        <property type="gene ID" value="RA11412_1501"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1501"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340098" evidence="1">
        <location>
            <begin position="40"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="167"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="229"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="294"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="347" mass="38889" checksum="72774903CF2FD943" modified="2018-10-10" version="1">MVKEITMKKVTTRRTSQAVGTAMCAVALGATLLGPAALAAPGDNAGYSGPYCAPFEHADMYYQLFPITFTAAAIEDAKAQTEHRGWNNEQIHQYLVAQLSQKLTEDNYPVNIQYYSYIQSGDRNYAEVEVSHFVTAAQGKGLLQKLLSYPTVQEAQVQPVPHPTVDGPCRFSDVPQNHPFYEEITWLEYRNITTGWADGTYRPLNNIERGAVAAFFYRLAGSPEVTLPAASPFTDVNPSHQFYHEIVWMHQQGLTTGWADGTYRPQDAVTREAMAAFFYRYAGKPDYVVVGPVFKDVPHDGAFYREINWLRSSGITTGWADGTYRPSEPIHRDAMAAFIYRYAHLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZX0</accession>
    <name>A0A2Z5QZX0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87810">
        <property type="protein sequence ID" value="BAV87810"/>
        <property type="gene ID" value="RA11412_1511"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1511"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="333" mass="36793" checksum="F778C6E69BB10341" modified="2018-10-10" version="1">MIVLLILMLLLLAPALWAYIYIWRGLNRRVIAAVKVVDPIITLGPYAMGAWAALSACVAVNIWCEGTARLIGNIITLTIAVGCALWAGFWLLMHCLGGQTPGKRPTWWREAVAAKFAWRNLESMPAYLGVRTSILPVANPRIVKPYSGSWTRPIGATMEGYLPDGSHTEGFDEHGRKMPRIYPVGPEPTAFEVARWGKSVSSDLLLHTFLPTAPFERLRMAGTITGPFTFAGAVPHGAVTKWPRRSGANRAFGNYARLGDITQRRVELLVDYRLVAALQTTRESYERRHSWVLAFTDITADDLTFDTSNDGKLQIVFGQVGEDYPTPGCLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZX7</accession>
    <name>A0A2Z5QZX7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RA11412_1624</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87923">
        <property type="protein sequence ID" value="BAV87923"/>
        <property type="gene ID" value="RA11412_1624"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1624"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="14">
        <location>
            <begin position="31"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV87923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="449" mass="46984" checksum="11C261C5BE2BACF2" modified="2018-10-10" version="1">MGAGRTRTAPIRLFLSPTDIHEESVKMSRKVLVTGLGATTPIGGDVPTTWANALKGVSGITTIDEPWVEEYDLPVYIAGRVAVPAQESERLSKVEAKRLDPSGQLALIAAREAWEDAGFSGPDAESAKETDPVRTGVAFGTGIGGVWTLLDAWDTLREKGPRRVLPMTVPMLMPNGNAAAVSMSLKARAAAQTVVSACASSTEAMELGVEMIRTGKADVVVVGGSEAAIHPLPMAAFAKMQALSSRNDEPQKASRPYDTDRDGFVMGEGAAAMVLESQEHAQARGARVYAELAGTGVSADSYHITAPDPDALGATRALREALEDGQIDPQSVVHINAHATSTPAGDLPEATAMHAAFGEHTKNIAVSATKSMTGHLLGGAGALEAVLTVLALHHRKAPRTINLENKDPQIDLDVVTDARDLPAGEIVGLSNSFGFGGHNAVVAFRSVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R032</accession>
    <name>A0A2Z5R032_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I6I94_01290</name>
        <name evidence="9" type="ORF">RA11412_1684</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87983">
        <property type="protein sequence ID" value="BAV87983"/>
        <property type="gene ID" value="RA11412_1684"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1684"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
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        <location>
            <begin position="69"/>
            <end position="329"/>
        </location>
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        <location>
            <begin position="370"/>
            <end position="615"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
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            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87983.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QQT89303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="618" mass="68292" checksum="BE4E4B907C21FF45" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R037</accession>
    <name>A0A2Z5R037_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87880">
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        <property type="gene ID" value="RA11412_1581"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1581"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="4876" checksum="5E55B83BBD4CA273" modified="2018-10-10" version="1">MGCRTGCRFWAHPHVCGEHNSLVTLDRYEQGSSPRMRGTHAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R040</accession>
    <name>A0A2Z5R040_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lepB</name>
        <name evidence="9" type="ORF">I6I94_01700</name>
        <name evidence="8" type="ORF">RA11412_1612</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87911">
        <property type="protein sequence ID" value="BAV87911"/>
        <property type="gene ID" value="RA11412_1612"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1612"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="147"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT90050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="356" mass="39440" checksum="658D03AE3A2BCD09" modified="2018-10-10" version="1">MGENAPQQSSEALDAGYSAPNEPQSNNNSNGSVTEPATDTDPDRTVSINRVKRSRPSRKPVSRDTRSISRTTRPASRNTAPQQTLYENPVRPKHLGTGAYSSDDYDYEYEDERSTKKSKKKDKKPELTLKQAREEGRMGEWAWTTFRESAMVVVYALVIAFIIKTFLVRGYYIPSGSMENTLQVNDRVFINAAGSYFGSPNRGDVVVFKDSQGWIDSAQKKSNPINDALTFVGILPDTSSNYLVKRVIGKPGDRVEGDGKGKIKVNGVEISEPYLHPGSNPSDVPFSVTVPNDSYFVLGDHRDHSADSRYHIGDGHAFVKRGDIQGNVFVIAWPINRVGLMTNQSDVFKSVPEPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R078</accession>
    <name>A0A2Z5R078_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87874">
        <property type="protein sequence ID" value="BAV87874"/>
        <property type="gene ID" value="RA11412_1575"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1575"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="40" mass="4262" checksum="5BA364A8CF771D4F" modified="2018-10-10" version="1">MTIEEGSSPRMRGTPTLKSIVGEENGLIPTYAGNTCCSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R091</accession>
    <name>A0A2Z5R091_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88137">
        <property type="protein sequence ID" value="BAV88137"/>
        <property type="gene ID" value="RA11412_1838"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1838"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="101" mass="10020" checksum="E963E5C7AAB57F85" modified="2018-10-10" version="1">MELIIPANLAYGEQAPENTKGALVFVIDIIDAKTNHSAVKAKEQTDALKKQAAEKAASASANPSGGAAPSQTPAPSGDGSASASASPAATEQKPSESASTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R092</accession>
    <name>A0A2Z5R092_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-terminal phosphate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88152">
        <property type="protein sequence ID" value="BAV88152"/>
        <property type="gene ID" value="RA11412_1853"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1853"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="82" mass="9516" checksum="F312E30C52BB1F51" modified="2018-10-10" version="1">MGRDGQYLLALMMTSKDHNNREHADRDYLDIGTGPWDAQGRPSEVKLNRVIRVRPEQMRREGAIMPQGTFKQIQDAYTRRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0B4</accession>
    <name>A0A2Z5R0B4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88205">
        <property type="protein sequence ID" value="BAV88205"/>
        <property type="gene ID" value="RA11412_1906"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1906"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4469" checksum="4E6A3846BACF7C92" modified="2018-10-10" version="1">MFVMLPNLDDTSQTVPGYMVRARTLFGLSAAGQPWCTKGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0D3</accession>
    <name>A0A2Z5R0D3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrC</name>
        <name evidence="8" type="ORF">I6I94_00590</name>
        <name evidence="7" type="ORF">RA11412_1879</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88178">
        <property type="protein sequence ID" value="BAV88178"/>
        <property type="gene ID" value="RA11412_1879"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1879"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="47"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="433" mass="46380" checksum="122FE70FDD6589E7" modified="2018-10-10" version="1">MSTYLIKGASLLGERVADILIEDGKIARIGQDLETADAQVVDASGQIALPGLVDIHTHLRQPGYEASETVETGTRAAALGGYTAVFAMANSLPVADTAAVVEQVDRLGKESGWCRVQPIGSVTVGLKGEFLSDIGSMATSEAKVRVFSDDGMCVYDPAIMRRALEYVKTFDGVIAQHAQEPRLTEGAQMNEGKVSADLGLTGWPAVAEEAIIARDVLLAEHLNSRLHICHLSTKGSVEVVRWAKSRGVQVTAEVTPHHLILTDEKARTYDPIFKVNPPLRTEEDVLALRQAVADGIIDVIGTDHAPHPAESKECEWACAANGMTGLEQALSIIQMTLVEPGHITWADVARIMSETPAKIGSLDAEQGRPLAEGEPANIVLVDPKATRVIKPEEQATKGKNNPYRGMEVPGAVRATFYAGHPTVLNGELASPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0G8</accession>
    <name>A0A2Z5R0G8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase</fullName>
            <shortName evidence="8">L-Cys:GlcN-Ins ligase</shortName>
            <ecNumber evidence="8">6.3.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mycothiol ligase</fullName>
            <shortName evidence="8">MSH ligase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mshC</name>
        <name evidence="11" type="ORF">I6I94_00360</name>
        <name evidence="10" type="ORF">RA11412_1933</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26176"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.13" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88232">
        <property type="protein sequence ID" value="BAV88232"/>
        <property type="gene ID" value="RA11412_1933"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1933"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035446">
        <property type="term" value="F:cysteine-glucosaminylinositol ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01697">
        <property type="entry name" value="MshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017812">
        <property type="entry name" value="Mycothiol_ligase_MshC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03447">
        <property type="entry name" value="mycothiol_MshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="9">
        <location>
            <begin position="33"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cysteinyl adenylate binding" evidence="8">
        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cysteinyl adenylate binding" evidence="8">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cysteinyl adenylate binding" evidence="8">
        <location>
            <begin position="269"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'ERGGDP' region" evidence="8">
        <location>
            <begin position="206"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="308"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="441" mass="48057" checksum="EA900209E49DEDA7" modified="2018-10-10" version="1">MRAWDAPAPVSLPGSAPLPRIFDTAANTVVQLEEPKKAGLYVCGITPYDATHMGHASTYVAFDLLNRAWRDAGVEVTYVQNVTDVDDPLLERATATNVDWQELAEDQTELFRTDMTALNVLPPDHYVGVVESIAWLFPVVEGLLERGLAYRVPGFTDEKGVQHPDGDIYLDVKATQALPADEEGYSWAPGQVSHMSREEMLSIFAERGGDPDRPGKRDALDPLLWRAAREGEPLWEAGALGAGRPGWHIECTMIARRFVNGPLTVQAGGSDLTFPHHDLGAGHSWAVDHRPHARHYAHTGMVGLDGHKMSKSRGNLVLVSKLRAAGVDPNAIRLAILDNHYRSDWFWTDDLLHKADARLETYRHAIAAATGDDTEGAVKTLDKVREYLADDLNAPEALKALDAWAIDALTRAQTTSTGAAAPVGGAELIRDILAARLGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0J9</accession>
    <name>A0A2Z5R0J9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase PriA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88163">
        <property type="protein sequence ID" value="BAV88163"/>
        <property type="gene ID" value="RA11412_1864"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1864"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="113" mass="11824" checksum="0B834C695789A1E9" modified="2018-10-10" version="1">MLAGAEADVQAFLAELNLPEGVRVTGPVPLDEDFFAHQHSAPAGVESGGEGDISEPSPSGAEDAVPGDWRAILFFTYAQAPQVTHELRSVRAALSALKRVGAVQVRCDGLDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0L5</accession>
    <name>A0A2Z5R0L5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrite reductase [NAD(P)H] small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88325">
        <property type="protein sequence ID" value="BAV88325"/>
        <property type="gene ID" value="RA11412_2026"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2026"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017881">
        <property type="entry name" value="NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40562">
        <property type="entry name" value="PTHR40562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske_2" evidence="2">
        <location>
            <begin position="11"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="100" mass="10837" checksum="32ACCB31A3C85FB0" modified="2018-10-10" version="1">MGTQAPESLSTRICAETDLEENWGEVALVEGHQYAIFKTKHGYYACDHLDPNSGALVIARGIVGEKDGHPTITSPLYKEVYDLTTGECVSGADYTIGVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0P7</accession>
    <name>A0A2Z5R0P7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88064">
        <property type="protein sequence ID" value="BAV88064"/>
        <property type="gene ID" value="RA11412_1765"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1765"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="126" mass="13761" checksum="EFAF8C5C3FCF05BF" modified="2018-10-10" version="1">MAAGIYKKFVELLPYPLRLIENPTRTQDVMGPYRELLSEGAREGFTPVILTLTEALLEAMRMNLADWAGCSQEQTDACALTAYTQQLVEKYRSALRGTTTMDIAQQAFTDTHPAAAAALFQGAGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0U0</accession>
    <name>A0A2Z5R0U0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome C oxidase polypeptide I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_1805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88104">
        <property type="protein sequence ID" value="BAV88104"/>
        <property type="gene ID" value="RA11412_1805"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1805"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="507" mass="56934" checksum="1D250BAB583BED9D" modified="2018-10-10" version="1">MRIELFEPGMQILQTKEQFNQLFTMHGTLMLLMFGTPLFTGLANVLIPLQIGAPDVAFPRLNALAFWFFLFGSLVAIAGFITPQGAASFGWFAYVPLNSTTYSPSVGGDLWVFGLALQGFGTIMGAVNFITTIVAMRAPGMTMWRMSVFTWTTLITSILIIMIFPPLASALFALGMDRRFGGHIFDPENGGAVLWQHLFWFFGHPEVYVLALPFFGVTSEIIPVFSRKPIFGYKGLVTATIAIAGLSVTVWAHHMYVTGAIMLPFFSFMTMMIGVPTGVKFFNWIGTMWQGSITFETPLLWIFGFLVTFLYGGLTGIILATPPLDFHISDTYFVVAHFHYVIFGTIVFGMFGAFYFWWPKFTGKMLNERIGKIHFWLVFFGFHATFLIQHWVGVDGMPRRYADYLPEDGFTWMNQFSTVGSMILAVSMIPWFWNVYITARYAPKVEVDDPWGFGGSLEWATSCPPPRHNFTALPRIRSERPALDLHHPELSTNHDVAAAALAAQKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0V0</accession>
    <name>A0A2Z5R0V0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="7" type="ORF">RA11412_1871</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88170">
        <property type="protein sequence ID" value="BAV88170"/>
        <property type="gene ID" value="RA11412_1871"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1871"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="218"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="223"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="340"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="451" mass="47906" checksum="B151551A0475D708" modified="2018-10-10" version="1">MRIIVGIGGGIAAYKAAMLLRLFGKAGHEVIAMPTNTALEFVGKPTLEALSGNPVHTSVFEQVPQVNHVRQAELADAVVIAPATADLLARLASGRADDLLSATVLTTHAPVILAPAMHTQMWEHPATRENVRILRGYGYHLIEPAVGRLTGPDSGVGRLPEPEDIFEAAQRVIAEFPKGKEHPSQTPGYAPTHPVHAGSTEDSDSLSAPSIEPEPGILAGKRIVITAGGTREALDPVRFLGNRSTGKQGVALAQAARDMGASVHLIGANLEVSAPDGVELTRVVSAADLQRAVLKSISGADALVMSAAVADFRPADYAEYKIKKTADPDDNPVIRLVRNPDILREVVQRRQQLGGGPRLIVGFAAETGSPDKTPLELGREKLTRKGCDFLAVNTVGISQGFGTDENTVTLISSLTDEAPFFRGLRGKYHGISSPPLQHIYELLCAVERHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0V2</accession>
    <name>A0A2Z5R0V2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MutT/nudix family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88367">
        <property type="protein sequence ID" value="BAV88367"/>
        <property type="gene ID" value="RA11412_2068"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2068"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="129" mass="14812" checksum="5E7B7FC0A2E67FA8" modified="2018-10-10" version="1">MHAGKLLTYSHHNKYFVPGGAVHVGEHSTDAVRREIREELGIDCTVRQLAFVGEHLFEVHGMPNHRIEFHYLVDVDSEAVPITTRDEGHHYPCVWLPLQSLADYPLKPEFLTHELPRWDGELTHIATVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Z3</accession>
    <name>A0A2Z5R0Z3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC iron siderophore transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88407">
        <property type="protein sequence ID" value="BAV88407"/>
        <property type="gene ID" value="RA11412_2108"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2108"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="249" mass="26774" checksum="1A94608397546EC0" modified="2018-10-10" version="1">MRWQDFVGTGEFFRSLESGIGRLRDRLVGIMRGTPAQAAKVEQALEHGLHAVAVDAAARAAEQVRRSWGSERPGALLLEEHDAGVTAEQVQTEQSTFETQVAEQIRAWQQGILETIRAEGAGKRQRARVLSLGVNAAAVLLMVAVFSATGGLTGLEIGIAGGSGVVGSKLLESVFGEDAARRMAQRARIDLIERMQNLLDVHRQRFTDSLNTVNAGPEPAQVLEAAQQTHRIGHELAVDGSPASKEIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R110</accession>
    <name>A0A2Z5R110_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86559">
        <property type="protein sequence ID" value="BAV86559"/>
        <property type="gene ID" value="RA11412_0260"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0260"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="42" mass="4375" checksum="2DC347B9499A55CB" modified="2018-10-10" version="1">MSAADARARREIWRLLLVLARAVGGMINNCVPASAGCGLYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R120</accession>
    <name>A0A2Z5R120_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00575</name>
        <name evidence="2" type="ORF">RA11412_1882</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88181">
        <property type="protein sequence ID" value="BAV88181"/>
        <property type="gene ID" value="RA11412_1882"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1882"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="281" mass="32193" checksum="AC9FE8C76B9665D4" modified="2018-10-10" version="1">MDSLLEPLFAAIFKALAVVARMIISVILEVFVEFLLELLIKAPIRWVASRFHKRRNRRRTRALTALYTPSATESIQQTITKVQRDSYLSVLAAILLGVLTILCILLWIASDYTIFLMVFWGVLVLLTAWAIWYYRRSYVSFELYEFTYSELGDGIKTTLYAAIDSYVFTYDGFASTLKITTINDETFCLNPAVQDCRYLCSMLAVRVQTGRWVNPTAERDAATVLHMMRSNDWLEFMLRVEQAKNLARTNLEVMHRTQNMSREEAAAEAETAKATLGFTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R124</accession>
    <name>A0A2Z5R124_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trk system potassium uptake protein TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88485">
        <property type="protein sequence ID" value="BAV88485"/>
        <property type="gene ID" value="RA11412_2186"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2186"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="105" mass="11261" checksum="3BBAD34570CF0ABF" modified="2018-10-10" version="1">MDVAVSTPRLMTALVEEAVEVGDVVRLLTLQAGGATLVEYTVPEDHPVIGYRVDHVQWPTDTVLTAILRDGAPIAPSADVVLEGSDELFFITTIAGEDQIRALFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R150</accession>
    <name>A0A2Z5R150_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86609">
        <property type="protein sequence ID" value="BAV86609"/>
        <property type="gene ID" value="RA11412_0310"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0310"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="40" mass="4127" checksum="70A50A6D9975B3B0" modified="2018-10-10" version="1">MLANHSFCTTYLSGVVTYLVGGYHASVDALAAHPTSRAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1A9</accession>
    <name>A0A2Z5R1A9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonucleotide reduction protein NrdI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88281">
        <property type="protein sequence ID" value="BAV88281"/>
        <property type="gene ID" value="RA11412_1982"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1982"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004465">
        <property type="entry name" value="RNR_NrdI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37297">
        <property type="entry name" value="PTHR37297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07972">
        <property type="entry name" value="Flavodoxin_NdrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00333">
        <property type="entry name" value="nrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="156" mass="16913" checksum="62EE8B9129444541" modified="2018-10-10" version="1">MTTPLAQKPTDENAEIREYILGARDAVEGRATTPVGDEAPLVVYFSSISGNTHKFVEKLHARTQRLPLRTGEDTLVVQEPYVLCVPTYGKPEGAGNVPPQVVKFLNVEENRRNMVGVIGAGNTNFGPLFGIAADIVSAKCDVPVLFKFELMGTPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1I6</accession>
    <name>A0A2Z5R1I6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="10">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 16" type="primary">secA</name>
        <name evidence="16" type="ORF">I6I94_10250</name>
        <name evidence="15" type="ORF">RA11412_2298</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 11">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88597">
        <property type="protein sequence ID" value="BAV88597"/>
        <property type="gene ID" value="RA11412_2298"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2298"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 10 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="14">
        <location>
            <begin position="2"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="88"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="847"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV88597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QQT88885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="870" mass="97805" checksum="562B50A37A9544F7" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1P7</accession>
    <name>A0A2Z5R1P7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88480">
        <property type="protein sequence ID" value="BAV88480"/>
        <property type="gene ID" value="RA11412_2181"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2181"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="133" mass="14077" checksum="D280C5DE41EE0A59" modified="2018-10-10" version="1">MSSAATFITALFPQLQGFRAGIAVTLIVVLSVVCLRGVQLMGRLAHWPLYIFLALLGITLVYGLLQAFTGTLARAESAGYTLTPETPHASLDGVFLVLLLSRSFSAGAVALSGFQLSPTRCGSSKHPSNAMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Q6</accession>
    <name>A0A2Z5R1Q6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88628">
        <property type="protein sequence ID" value="BAV88628"/>
        <property type="gene ID" value="RA11412_2329"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2329"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="89" mass="9930" checksum="AF06F412846E4FF5" modified="2018-10-10" version="1">MFLGFALRRERVGSGFLTGRTVRGIQWGTVDVSCPRGGYFGCGARTVTTFVLAHPVWAIKEKGHLYGRGKKQRGLTRLVIRWCANPLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1S5</accession>
    <name>A0A2Z5R1S5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyroglutamyl-peptidase I</fullName>
            <ecNumber evidence="6">3.4.19.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_09850</name>
        <name evidence="7" type="ORF">RA11412_2398</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.</text>
            <dbReference type="EC" id="3.4.19.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.3" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88697">
        <property type="protein sequence ID" value="BAV88697"/>
        <property type="gene ID" value="RA11412_2398"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2398"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033694">
        <property type="entry name" value="PGPEP1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PTHR23402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01334">
        <property type="entry name" value="PYRASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="224" mass="24160" checksum="F3ABC41685A697B5" modified="2018-10-10" version="1">MTKTLLITYFGPFPGVSVNPSGVTARQVADVLADESAVRVVTREIPVSYAGSSEALEEMLTDIRPDAVLSLGVAVGRDKVSFEKVAINLDSADIEDNDGVVRVDKAIAPEGRDAYFSTLPVRASYERLRGVGLPVEISYTAGTYVCNHVFYEAHRILERQGRRIPAGFVHIPATRVDHEPSDAQTTLTAHADTGGVESESVPTLPEAVVARIVAELVRDTLKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1S9</accession>
    <name>A0A2Z5R1S9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88658">
        <property type="protein sequence ID" value="BAV88658"/>
        <property type="gene ID" value="RA11412_2359"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2359"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="5092" checksum="5469DB1D7F7DDD6E" modified="2018-10-10" version="1">MRRAGYRAGFGHISQCARFWTCVFTTHCHIPTCFTPRTRHIGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1T4</accession>
    <name>A0A2Z5R1T4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyuridine-triphosphate nucleotidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88494">
        <property type="protein sequence ID" value="BAV88494"/>
        <property type="gene ID" value="RA11412_2195"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2195"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="77" mass="8277" checksum="60D6229AEB13C1ED" modified="2018-10-10" version="1">MINPINVQIKMLDPELPAPAYTKPGDAGADLRSRVDFTLNPGERALVPTGLALALPEGTWVWCIRAPGWPLNTASPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1U1</accession>
    <name>A0A2Z5R1U1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Topoisomerase IV subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88504">
        <property type="protein sequence ID" value="BAV88504"/>
        <property type="gene ID" value="RA11412_2205"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2205"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003916">
        <property type="term" value="F:DNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="255" mass="25863" checksum="D02EBEB864E10C1B" modified="2018-10-10" version="1">MVRLSVMDVVVLEESAGAPVLNSGVKVSEVVSLAKGEKLVGLVPLNEVLALATANGVIKRVNPEYPLNQAEWDVIKLKPKDTVVAAAACASDDNALTLVTQDAKLLTFDAAKVRPQGRGGGGIAGIKLGAQDAVIALGVTAPGTTAEVVTVTDGKDGLASVKVTPLAEYPQKGRATGGVRAHRFLTGESKLALAWVGVGPAKAGTQGGVARSLPTEYGSRDGSGVTLTQTIGTVGPNYAALTAQSAVSPDGEKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1X5</accession>
    <name>A0A2Z5R1X5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88693">
        <property type="protein sequence ID" value="BAV88693"/>
        <property type="gene ID" value="RA11412_2394"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2394"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016330322" evidence="2">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="67" mass="6841" checksum="E3E63C6929DE0219" modified="2018-10-10" version="1">MSALKTIRRATVAVGLSAVLLAPLAPAQAASRPAPEPRPSSSPSYSPQGAGKTLGKIIANILKQLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Y5</accession>
    <name>A0A2Z5R1Y5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SNARE associated Golgi protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09530</name>
        <name evidence="4" type="ORF">NCTC10207_01687</name>
        <name evidence="2" type="ORF">RA11412_2468</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888771.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88767">
        <property type="protein sequence ID" value="BAV88767"/>
        <property type="gene ID" value="RA11412_2468"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2468"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI23708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="157" mass="17247" checksum="DF0A36951B79EB8F" modified="2018-10-10" version="1">MKEWFDSLPVEAAVACLWAIGIIRTSIVFLLGYLAAAGGARLSRIREAMDTPIYQRATAFVNRWGVLAVPLCFLTVGFQTAVIITTGFTKMPLRRWVPAMLVGTFIWAVIYTTVGFAVLAALGLQPWMLPVALAVIVLLSLGISKVRELITDRKPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R208</accession>
    <name>A0A2Z5R208_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LpqB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88600">
        <property type="protein sequence ID" value="BAV88600"/>
        <property type="gene ID" value="RA11412_2301"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2301"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018910">
        <property type="entry name" value="Lipoprotein_LpqB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10647">
        <property type="entry name" value="Gmad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gmad1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="261" mass="28064" checksum="9D3BBB12B7DEBD6E" modified="2018-10-10" version="1">MSPEISKRVVGLEDGKLVIREDYLSQQPETTGTESVTDASDPAINYDGTALACLGDTGRSLYFFSGGKGQYLVKNKKMTAPSFDSFGWLWVAESDGAVRAYNAASTNEKERSKGIEIPVSWRSGMTFSSLRVSHDGARVVVVGTRDGTAAVVMSGVVRYSSGTPKGFTEPVRVTSSITPRTAVWAGEQNLVVVNDKTGESEVTTLSGEETKFDRLDGVKSVSAAGNTSNMLAHRSDGSCYVLEERGWNRLNTSTREMSFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R212</accession>
    <name>A0A2Z5R212_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86929">
        <property type="protein sequence ID" value="BAV86929"/>
        <property type="gene ID" value="RA11412_0630"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0630"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="57" mass="6422" checksum="C9196010FC2323D7" modified="2018-10-10" version="1">MSDHKVEFVDVAAMAQWIQKDGVGNIIAGMVDFLEEDFKKWQSFDKIPRVASHTPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R216</accession>
    <name>A0A2Z5R216_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88733">
        <property type="protein sequence ID" value="BAV88733"/>
        <property type="gene ID" value="RA11412_2434"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2434"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="185" mass="20772" checksum="F925FECAFADFFBD5" modified="2018-10-10" version="1">MAALIRSHSIGGRAHIVGLSLGGFVAIELIRRHPTLAYTCTISGSPLLGYTRWERMVIGAQVPLWHRRWYWIAQSRPFNIPAEDRELFVQTASSPQPLTNTLLFRELGVRALPAEPFSFTGPVLAVAAEHDTPSVRRSFDPLRKCLPQLRTWVAPGMPHAWSAENPELFARMVTTHADTGRWPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R231</accession>
    <name>A0A2Z5R231_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase MshA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88817">
        <property type="protein sequence ID" value="BAV88817"/>
        <property type="gene ID" value="RA11412_2518"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2518"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="39" mass="3933" checksum="18DB55115384070F" modified="2018-10-10" version="1">MSISTPPSCVSSETAARVVHVFSMHTDPFAQPGSGDAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R292</accession>
    <name>A0A2Z5R292_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable sensor histidine kinase pdtaS</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Serine phosphatase RsbU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pdtaS</name>
        <name evidence="3" type="ORF">I6I94_10280</name>
        <name evidence="4" type="ORF">NCTC10207_01543</name>
        <name evidence="2" type="ORF">RA11412_2292</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006889139.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88591">
        <property type="protein sequence ID" value="BAV88591"/>
        <property type="gene ID" value="RA11412_2292"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2292"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038424">
        <property type="entry name" value="H_kinase_PdtaS_GAF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022066">
        <property type="entry name" value="PdtaS_GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12282">
        <property type="entry name" value="H_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="314"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI23435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="521" mass="56948" checksum="CF4468C7D0EA5EBF" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2D9</accession>
    <name>A0A2Z5R2D9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="3 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">gcvT</name>
        <name evidence="11" type="ORF">I6I94_09035</name>
        <name evidence="10" type="ORF">RA11412_2589</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3 7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88888">
        <property type="protein sequence ID" value="BAV88888"/>
        <property type="gene ID" value="RA11412_2589"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2589"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="8">
        <location>
            <begin position="8"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="9">
        <location>
            <begin position="290"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT88656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="372" mass="40019" checksum="7C98B4A876EB7C4D" modified="2018-10-10" version="1">MSPKKTALYPVHEKLGASFTDFGGWDMPLKYANDVAEHEAVRTRAGIFDLSHMGEFRVSGPDAAAFLDYALVSNMSVLKPGRAKYSILVNDKGGVIDDLITYRLGDEEFLVVPNAANIDKDFAAMSERLGDFDVKFVNESEETSLVAVQGPRAEEILLAAGASDEDAVREVKYYASVPVTIAGVDVLLARTGYTGEDGFELFVPNADAVKLWEALAAAGEPFGLTPAGLASRDSLRLEAGMPLYGHELGLDITPFESGLGRLVEIALEKKAVDFVGRAALTELAKSPSERILVGLKAQAKRPARAGSFLVDAEGNQIGEVTSGIPSPTLGYPVAMALVKREFSEVGTEVDVDIRGKRATFDVVPLPFYKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2E8</accession>
    <name>A0A2Z5R2E8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdenum cofactor biosynthesis protein MoaE</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Molybdopterin synthase catalytic subunit 1</fullName>
            <ecNumber evidence="3">2.8.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">moaE1</name>
        <name evidence="2" type="ORF">I6I94_08990</name>
        <name evidence="3" type="ORF">NCTC10207_01805</name>
        <name evidence="1" type="ORF">RA11412_2599</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.1.12" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887700.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88898">
        <property type="protein sequence ID" value="BAV88898"/>
        <property type="gene ID" value="RA11412_2599"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2599"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI23923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="162" mass="17175" checksum="E3673FB41E28382C" modified="2018-10-10" version="1">MTTKPQGLDHSGAHGAEPTGSVVIFTDITEEALEPLANAAKAQVMTEAMGALVVFDGIVRNHDHGSAVRGLSYSAHPQAKEYIARVVQSVADELEGVRLWAVHRVGPIAIGESALTVLAAAAHRGRAFEACEAVADRVKAQVPIWKEQELTDGSTEWVGIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2J4</accession>
    <name>A0A2Z5R2J4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">PIG-L family deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_09875</name>
        <name evidence="3" type="ORF">RA11412_2392</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88691">
        <property type="protein sequence ID" value="BAV88691"/>
        <property type="gene ID" value="RA11412_2392"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2392"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="455" mass="48618" checksum="208817CB25C081E4" modified="2018-10-10" version="1">MNAKLKEAASTVMSEATPSYPQQGTRVVSASKRNLLPNGRLIKDGVLLFVHAHPDDETSSTGATMAAYAREGAKVHLLTLTRGEMGEVIPEDLKHLQVGDPECTDNGEALGEYRTGELVAASRTLGVASRFYLGQAPATATGTRKIYRDSGMVWGEDGKPAPNPKASSDSLTAEPIEPQAQAIANAIRSIKPDALITYDADGGYGHPDHVRTHRAVMQALSLLKSSQKPVLVWGIEGEFDETDKRTQAAIYGSTTAKRKAMREYGTQIVVTGDDTFEYSNGVEQKISGVETYRLLAGDANIEVPSGHEPAGIISTSFTSILLGIMAALGGSIYHAWIQYAGDTPIPVGLGLGYLTVFFASLWGATMMRRPVAAPIQAAAVFITIFAFAYARPEAPFVLVNPTAGAAIGIVGTCWLMGAPIIVMLAAPVAVRSLRNEKQQLREHKSAPSFSQPHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2N7</accession>
    <name>A0A2Z5R2N7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87159">
        <property type="protein sequence ID" value="BAV87159"/>
        <property type="gene ID" value="RA11412_0860"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0860"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="63" mass="6835" checksum="F4AE56FB6047B725" modified="2018-10-10" version="1">MPRISAATNAAQRENTKRAILESFGKLLYSRGLPGLTMTDVAKMLALAAPQSITISPTWANCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2V6</accession>
    <name>A0A2Z5R2V6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88952">
        <property type="protein sequence ID" value="BAV88952"/>
        <property type="gene ID" value="RA11412_2653"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2653"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="219" mass="24335" checksum="8A648E27B21ED3CB" modified="2018-10-10" version="1">MDYEFVDYFFFNPPAYNPLNPKNFRGFSNEGAYDFEDQELFFEYSADSENLYIAAVSDTGDDRVCYVRGRIEPTLKVVWEIRSDDPEFMEFMAAILDAVRTSLGVTPPHLSEGEMMEVTGTIERVEPIVGASYHTVAGGVVVRFVNVEFVPHHPLTQAASYFAKVVGRGVPSGSVVWSGPRRVVFWEGADDDGDNPLHGKSIPAPVNYAVKRLPVVEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R307</accession>
    <name>A0A2Z5R307_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rplR</name>
        <name evidence="10" type="ORF">I6I94_09180</name>
        <name evidence="11" type="ORF">NCTC10207_01765</name>
        <name evidence="9" type="ORF">RA11412_2552</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037234572.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88851">
        <property type="protein sequence ID" value="BAV88851"/>
        <property type="gene ID" value="RA11412_2552"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2552"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT88685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VEI23843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="120" mass="12906" checksum="4BF7342DDEED8FC7" modified="2018-10-10" version="1">MAIKSKAAQRARRHARLRKHISGTAARPRLCVTRSSRHMFVQVIDDVKGVTLASASTMEADLRAATELTKTAKAKRVGELIAERAKAAGIETVVFDRGGNKYHGRVAAVAEGAREGGLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R337</accession>
    <name>A0A2Z5R337_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M20D amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87329">
        <property type="protein sequence ID" value="BAV87329"/>
        <property type="gene ID" value="RA11412_1030"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1030"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="135" mass="14652" checksum="BA0E334D0963BA37" modified="2018-10-10" version="1">MAPNAIPAEGYLAGTMRCLDVEVWRHAGQLLDEVIEQVAVPFGVNARVEHIRGVPPVVNTDTETTMIENAARAELGEDSIVLVEQSMGGEDFAWMLQEVPGSMFRLGTRAPEDPTYDLHQGITTPMNALSAWACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R387</accession>
    <name>A0A2Z5R387_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89064">
        <property type="protein sequence ID" value="BAV89064"/>
        <property type="gene ID" value="RA11412_2765"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2765"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV89064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="168" mass="18494" checksum="027BDAE19D54948C" modified="2018-10-10" version="1">MGELLNAAMDPSINYEDLKEIRSIWPGKIVIKGVQNVEDSKKLADLGVDGILLSNHGGRQLDRAPVPFHLLPEVVREVGMDTEVMVDTGIMNGADVVACLALGAKFTLIGRAYLYGLMAGGRRGVDRTIEILSEEVRRTMKLLQVQNVAELEPKHVTQLRRLQPIPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3B3</accession>
    <name>A0A2Z5R3B3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA ligase</fullName>
            <ecNumber evidence="8">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ligA</name>
        <name evidence="10" type="ORF">RA11412_1180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87479">
        <property type="protein sequence ID" value="BAV87479"/>
        <property type="gene ID" value="RA11412_1180"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1180"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="9">
        <location>
            <begin position="378"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="468" mass="50994" checksum="487134355AE6D73A" modified="2018-10-10" version="1">MGLPVSPYTETFTAVEDIFAYIERYGQQRHSLVHEIDGIVIKINDFATQRQLGYTSRVPRWAVAYKYPPEEVNTKLLDIRVDVGRTGRVTPYGVMEPVLVSGSTVEHATLHNQDVVKAKGVLIGDTVVLRKAGDVIPEIVGPVVALRDGSEREFVMPTLCPSCGSPLAPGKEGDVDLRCTNLQSCPAQLTERIYYAASRAAFDIEALGFEAAKALTAPAEPAEPPLRSEAFLFDLTEEDLREVKIEREKKVKGVGTGKTELVPYFWSKGTAKRPSAPTKNTRNLFVELQKAKQQPLWRVLVALSIRHVGPTAARALATEFGSMDAIRAADRDRLAAVDGVGSTIADSIINWFAVDWHAEVVNRWAQAGVRMQDERDESIERTLEGVTVVVTGTLNDFTRDSAKEAIIVRGGRASGSVSKKTHFVVAGASAGSKLDKAESLGITVLDEDGFKKLLTQGPSAFDSDTEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3C0</accession>
    <name>A0A2Z5R3C0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87499">
        <property type="protein sequence ID" value="BAV87499"/>
        <property type="gene ID" value="RA11412_1200"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1200"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="53" mass="5895" checksum="6169FDCEE1C87F4C" modified="2018-10-10" version="1">MTFQPKAHAVFRAEKSLSAHNTLWVSAEALLNAYGCCSFPRYYPQVTVSGFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3Q8</accession>
    <name>A0A2Z5R3Q8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RA11412_1530</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87829">
        <property type="protein sequence ID" value="BAV87829"/>
        <property type="gene ID" value="RA11412_1530"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1530"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="12">
        <location>
            <begin position="25"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="10">
        <location>
            <begin position="215"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="11">
        <location>
            <begin position="413"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV87829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="635" mass="68195" checksum="BA0338136E3F98BB" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4A9</accession>
    <name>A0A2Z5R4A9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 16" type="primary">rpe</name>
        <name evidence="16" type="ORF">I6I94_10845</name>
        <name evidence="15" type="ORF">RA11412_2150</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88449">
        <property type="protein sequence ID" value="BAV88449"/>
        <property type="gene ID" value="RA11412_2150"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2150"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="195"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV88449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QQT88983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="229" mass="24225" checksum="0C33B84D8ABFF478" modified="2018-10-10" version="1">MGIHINPSILSADFANLQAELENISTADAAHIDVMDNHFVPNLTWGLPVVKRLREVSPVPFDVHLMIEDPDRWAPQYAQVGCESVTFHAEAATAPIKLARTLRELGAAAGMALRPATPVEPYLDMLSELDMLLVMTVEPGFGGQAFLDVTLPKIRRAAEAVAGSGTPVVVQVDGGVTRESIVRAAEAGATCFVAGSSVYGAQDPQQAIASLREAATRAYAKTWGACGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4K1</accession>
    <name>A0A2Z5R4K1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lon-like protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88619">
        <property type="protein sequence ID" value="BAV88619"/>
        <property type="gene ID" value="RA11412_2320"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2320"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="105" mass="11292" checksum="3A861B10BBD70C31" modified="2018-10-10" version="1">MSESNYVAGTGTINAEGKVGPIGGAKYKIIAAGDKGVAVFLVPKENCSDVNEMRKSNPELLKYRDSNGQRQQMQIVAVENLDQAVQSLERIRDKGIHTDGLPTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4X1</accession>
    <name>A0A2Z5R4X1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MutT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88939">
        <property type="protein sequence ID" value="BAV88939"/>
        <property type="gene ID" value="RA11412_2640"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2640"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="248" mass="27730" checksum="A9C58ED090B1912F" modified="2018-10-10" version="1">MSIKKARTMLTNPSDLQPLEAFENLWATSGLDTHPIIIARHTKAKPRANWSAAEDERPLAGTGKRQALALARLLPAWEPSRVLSSPWLRCVQTVAPYVNEYSLTVKEKKSLSEAGAERHPKRTAKTIASLFEKGTPALVCTHRPVLPVVLDAVAEHLLTKKQKEHLPAKDPYLEPGTYWCFRSPRTNAAASYRLKWCARSRTKNPARMPSIPAPLQTWGRDYYCPDELFCAVGALPHLQYNGILAKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVA3</accession>
    <name>A0A2Z5QVA3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Osmosensitive K+ channel histidine kinase KdpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86312">
        <property type="protein sequence ID" value="BAV86312"/>
        <property type="gene ID" value="RA11412_0013"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0013"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="176" mass="18939" checksum="37177E1F1E7712F7" modified="2018-10-10" version="1">MFLLARTGGHLTTATLGRRGAALVILISGIIGLLLGAVSMSFLRRSEREWANNSVVEPALSDGAAQVLAVIGRAYVVVDEVGGVAQASPGAYAMGLVRGHTVVSEQLSEMIRTVRHRGIFVEQEVEVDRGEGETLVIDLRVAPVGMSTCWCWPMTAPKFRVCSVCAMILWPTFHMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVE2</accession>
    <name>A0A2Z5QVE2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86336">
        <property type="protein sequence ID" value="BAV86336"/>
        <property type="gene ID" value="RA11412_0037"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0037"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="4209" checksum="A19E65F1D99B34AC" modified="2018-10-10" version="1">MEHRTLLPRRLAPQNAVALLVFHRYSRALGGHQKSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVE3</accession>
    <name>A0A2Z5QVE3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">tgt</name>
        <name evidence="7" type="ORF">I6I94_07950</name>
        <name evidence="6" type="ORF">RA11412_0052</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="RA11412_0052"/>
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    <dbReference type="KEGG" id="raj:RA11412_0052"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="41"/>
            <end position="431"/>
        </location>
    </feature>
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            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="4">
        <location>
            <begin position="334"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
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            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
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    <sequence length="436" mass="47965" checksum="02E123EA2FD8DC11" modified="2018-10-10" version="1">MSSSNSEFPNPGFGFTVTSRLAETASPSAERVEANGGQFLGRTGVIRTPHGDIETPAFTPVGTKATVKAVLPEAMKELGAQALLANAYHLYLQPGPEILDAAGGLGRFMNWDGPTFTDSGGFQVMSLGSGFKKVIDMGTVADAKGADGRPIGDDDVAHGKDRLAHIDDDGVNFKSHINGSIHRFTPEVSMQVQHQIGADIMFAFDELTTLYNSRGYQEEALERTRLWALRCIAEHERLTDERTGKPYQALFGVIQGAQYEDLRRKACRDLGDMPFDGFGIGGALEKENLGTIVRWCAEELPEAKPRHLLGISEPDDIFVGLENGVDTFDCVSPTRVARNAALYSPTGRFNVTNARFKADFSPIYEGCDCYTCTHYTRAYLRHLFKADERLAATLASIHNERFIVRMVDDARAAIADGTYFEYRDEFLGNYYSGKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
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    <name>A0A2Z5QVH4_9MICC</name>
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        <lineage>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <begin position="44"/>
            <end position="67"/>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
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    <name>A0A2Z5QVN8_9MICC</name>
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    </gene>
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        <lineage>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
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            <begin position="1"/>
            <end position="143"/>
        </location>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="159" mass="16951" checksum="2884879DBC25716B" modified="2018-10-10" version="1">MDAGSTIEILADQIGAENFSLKTGSDRIIITHALHIAVKLAEAEGITMELVGGQLRKMTWAAIGARAANYFSTVRPDIAFIGANGIGAEFGVSTPGMNEAIVKTAICKSARRVVLLCDSAKFGNESLVRFADFEDIDTLITDRAPEGELAQALEGPVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVP7</accession>
    <name>A0A2Z5QVP7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86468">
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        <property type="gene ID" value="RA11412_0169"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="49" mass="5460" checksum="2B95C84062279AC4" modified="2018-10-10" version="1">MVVSHGSLIRRAISAAQGYEHTQEVPNAQPLEVDIAGLFAWDSRRYFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVQ2</accession>
    <name>A0A2Z5QVQ2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86374">
        <property type="protein sequence ID" value="BAV86374"/>
        <property type="gene ID" value="RA11412_0075"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0075"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041629">
        <property type="entry name" value="SCP_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17844">
        <property type="entry name" value="SCP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="57" mass="5979" checksum="F77F4E0EC3D2B87D" modified="2018-10-10" version="1">MAGPRHTRGTPPSVVEASAFVWCALALGVLGWADALGSAQLSASGERSDISRYFPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVR1</accession>
    <name>A0A2Z5QVR1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86470">
        <property type="protein sequence ID" value="BAV86470"/>
        <property type="gene ID" value="RA11412_0171"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0171"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="120" mass="13179" checksum="F70DC1DFD85D8CBB" modified="2018-10-10" version="1">MLRHGLTDWNIEHRFQGNTDIPLNDAGREQVRGALTEFAALASDGVPVDGVVSSPLVRAVESGKIIAEGLGVPYLGAYEGLQERGFGELEGLVATPSWWRMPAAVRTRRLSRVRSLWRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVS2</accession>
    <name>A0A2Z5QVS2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Excalibur calcium-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_07795</name>
        <name evidence="5" type="ORF">RA11412_0095</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86394">
        <property type="protein sequence ID" value="BAV86394"/>
        <property type="gene ID" value="RA11412_0095"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0095"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008613">
        <property type="entry name" value="Excalibur_Ca-bd_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05901">
        <property type="entry name" value="Excalibur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00894">
        <property type="entry name" value="Excalibur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340088" evidence="3">
        <location>
            <begin position="31"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Excalibur" evidence="4">
        <location>
            <begin position="247"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV86394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="354" mass="35288" checksum="859A840F8C8A40E3" modified="2018-10-10" version="1">MSIRTKFTTFSIVAALGCGMVGATVPAAFAAPGSVPAAAAHVYEDGASLQFPDTWTVGQPLHFTGTGFKATDGSPSILAIKINGGPVSGARYLEVKADADGNISGSIPWQENLKAGESVEINVLTGSLNKKDRQRGGVAATVTVVDNSAAPSDPSVPKDTPSETPSPSEKPSSVPSESPSAPAPSASSPVAAPSESPSESPAESPSATPSETAPSQQPSATSSETSSASAEASVNAGADTEASPTPRFQNCKEVQDAGLAPIHKGHPDFQEKFDADHDGVGCEKDADYENSASRVDSNGGVAASDSNNNSGGSISGRLASTGAAGVATIAGLGLAAVGAGVAAIVVMRRRKQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVS9</accession>
    <name>A0A2Z5QVS9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86498">
        <property type="protein sequence ID" value="BAV86498"/>
        <property type="gene ID" value="RA11412_0199"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0199"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="124" mass="12888" checksum="78F542943D7CE8BF" modified="2018-10-10" version="1">MPYNPATDNVGASNMPYNPADTSVQEPLQMPTRVEPNNGYTPPQVSVAEQIASAAFGGSADDMMAGDLETAKWEEPTQGPAYMPYDPATDSGEVANLPYNPNTDNGGPIFLQNAAAPELAGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVT1</accession>
    <name>A0A2Z5QVT1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydrolipoamide acetyltransferase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86490">
        <property type="protein sequence ID" value="BAV86490"/>
        <property type="gene ID" value="RA11412_0191"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0191"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="2">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="327" mass="35200" checksum="41067D757040BAB0" modified="2018-10-10" version="1">MENTPLNSSLNTVRQRLQGAEAPALEQDAAAPVPHRPALAAPPVRLAAKEMGVDLANVTATGSRGQVTKQDLLDYVAHLNDVQETGGRFWQPPSVPGDRLERIPVRGVRKATAKAMVSSAFSAPHVSIFVDVDASRTMEFVKRLKKSRHFEGIKVTPLLVLAAAVIWAAERNPQVNATWTDSEIQIKHFMNLGIAAATPRGLMVPNIKDAQELSLRELAIALNNLTARAREGKTQPAEMANGTLTITNIGSLGIDTGTPIINPGEVAIIAFGTIKQKPWVVDGEVIPRWVTTLGGSFDHRVVDGDLSARFMADVAAILEEPAMLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVX7</accession>
    <name>A0A2Z5QVX7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86565">
        <property type="protein sequence ID" value="BAV86565"/>
        <property type="gene ID" value="RA11412_0266"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0266"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="64" mass="6804" checksum="E2678F2A229EA888" modified="2018-10-10" version="1">MNGANTDLKDSQGHTYAVDRVGSGMINAKAAVEAKVLAYDTKQPERVSTAFGVLEYTPDSGCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW50</accession>
    <name>A0A2Z5QW50_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_06820</name>
        <name evidence="1" type="ORF">RA11412_0313</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86612">
        <property type="protein sequence ID" value="BAV86612"/>
        <property type="gene ID" value="RA11412_0313"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0313"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="54" mass="6134" checksum="1D02AF7621C4BD75" modified="2018-10-10" version="1">MEIPRAERRWDTMSFYDYVETAQALLVSFALTDGAAQAVSYIMSFASNLIKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW61</accession>
    <name>A0A2Z5QW61_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter membrane-spanning permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86622">
        <property type="protein sequence ID" value="BAV86622"/>
        <property type="gene ID" value="RA11412_0323"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0323"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="209" mass="22543" checksum="7BB3E5598EAB2EA9" modified="2018-10-10" version="1">MGNDETVINQVVNRYSRAHNLIPATALSRVGSIAYTVVVAWYVSQHAGNQMVGLMNALNGAGVLLASILGFTIIDRYNKKTLLIAYDIINSIFCIVAAVLSIYLDRHASVFIVLILSAWLSLIATIYAPTSRAIIPEILHTQEFEKYNSVYSVVGELSRSAGPLVGAAILAQQTADALEAALIVNFVSFMLSLVITLYLPSGGVCLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW98</accession>
    <name>A0A2Z5QW98_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86661">
        <property type="protein sequence ID" value="BAV86661"/>
        <property type="gene ID" value="RA11412_0362"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0362"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="70" mass="7429" checksum="C4180ADAC421A693" modified="2018-10-10" version="1">MVVYPDGFVEPENMVVPQAAVAAPAAENKPFYKRAVFLVPLALVLVVGLLGGGVWGSCFFSRIRGENCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWL6</accession>
    <name>A0A2Z5QWL6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major myo-inositol transporter IolT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_0315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86614">
        <property type="protein sequence ID" value="BAV86614"/>
        <property type="gene ID" value="RA11412_0315"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0315"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="29"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="486" mass="51795" checksum="94B4D1F43D37D9AF" modified="2018-10-10" version="1">MSITTEPPNRASTLPPLGQGSHTRRLGVIALVATFGGLLFGYDTGVINGALDPMSRELGMDNTIQGWVTGSLAFAAALGAMVTGRISDAIGRRKTIIGLSILFIAGALACVFTPSIAVLLMGRTMLGLAVGGASAVVPVFLAELAPYEIRGSLSGRNELMVVGGQLAAFIVNAIIGNLWGEHDSVWRWMFAVCALPALALFIGMLRMPESPRWLIAQGRTEDARAIMRRIRPAERADAEIADIARSLEETRTQIGAGTRGSMGKILREKWFVRILLVGILVGAGQQLTGINSIMYYGIKVLKEAGFDEGSALIANIAPGAIAVVGSVFSLRMMERVNRRTMVIAGYSLTAFFHLLIGVASMLLPEGTPARPYIILALVVGFVGSMQTCLNVSTWVLMSELFPLRVRAVGMGLSAFCGWMMNGLLSLVFPVILGALGLTGSFFGFMVVNVLIAVLMWRNLPETRGKTLEDVEAGVISGAAYPFGTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWS9</accession>
    <name>A0A2Z5QWS9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86793">
        <property type="protein sequence ID" value="BAV86793"/>
        <property type="gene ID" value="RA11412_0494"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0494"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="89" mass="9936" checksum="821A784AF8F70CC3" modified="2018-10-10" version="1">MFCCKKRKARKAAKNAAVVAAMAVAEKANDLNVPQKAELFAEKLTGDRKAMKKARKVAAKTARKAQKELKGIERRGGKRRPVRLWLFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX55</accession>
    <name>A0A2Z5QX55_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fused MFS/spermidine synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05390</name>
        <name evidence="2" type="ORF">RA11412_0671</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86970">
        <property type="protein sequence ID" value="BAV86970"/>
        <property type="gene ID" value="RA11412_0671"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0671"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT90021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="288" mass="31112" checksum="1404BD1F5CDB67F0" modified="2018-10-10" version="1">MAKKKTRSAASRRAERSEYPHTTGAVAGVYPISTGEAELVPDGYHADGWLLLINGVQSSHVIVGQPRMLDFEYMRWIAAVLDSHIQTHLNPDKLRITHLGGGACSLARYCVDVYPNSRNTVVELDAKLAEYVREWFDIPKSPRVKIRVGDAGTVTRSFAPASRDVVIRDVFAVDKTPAELTSVDFVRTVDHSLAPGGLYILNCGDGPSLDGARAEVAALFEVFEQVCLVADAAMLKGRRRGNIIIAASHSPLPAAGSAEAAAISRTLMGGGVPAQYRDSAQTRQFARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX72</accession>
    <name>A0A2Z5QX72_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87028">
        <property type="protein sequence ID" value="BAV87028"/>
        <property type="gene ID" value="RA11412_0729"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0729"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="46" mass="5371" checksum="1C17FFCF66F30198" modified="2018-10-10" version="1">MDHLQELNQDKNNPKDTEEKEEPHNIRHTKTSVAKETQRKQRCGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX86</accession>
    <name>A0A2Z5QX86_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_05010</name>
        <name evidence="3" type="ORF">RA11412_0758</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87057">
        <property type="protein sequence ID" value="BAV87057"/>
        <property type="gene ID" value="RA11412_0758"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0758"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="205" mass="23199" checksum="8285F6166ECCBE07" modified="2018-10-10" version="1">MQRPVAEAATRRPGRTSKTQLKLFNAAMEIMGQRGPEFATVEEVAQLAGVSKGTVYYNFGSKKTMIDQLLQYGTDLLLRQMEAAAQMHSDPREALRASIYTALKYLEDRPGYARLWIAEVWKSMNDWSESMIDSRQSLLDFIEARVAALSKRYMIDRAQDVRSTSVAIFGAAYMLSMDRVIHSSPRTAEDATRAVMQVVDGYIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXA5</accession>
    <name>A0A2Z5QXA5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable conserved integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_0769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87068">
        <property type="protein sequence ID" value="BAV87068"/>
        <property type="gene ID" value="RA11412_0769"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0769"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="207" mass="23683" checksum="9FAC30F471A93D25" modified="2018-10-10" version="1">MTRYRWGITGACILFLAGVIVYNLREFLAYDYLVYYAGGKSVNWFLDYPSNLYDLDILRETVRAENFRYIFGDSGLWLAFTYPPFASLLFIPASFLPLRVAIGLHLAFFVPIAFYCAKVLRDYLAKRNSRLLFEKYLSPFSFIVLCAALILLSAPWRNNFLYGQINPYLLVLILYDLLRPGTRIPRGVFIGIAAGIKLTPLAIGVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXH8</accession>
    <name>A0A2Z5QXH8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87020">
        <property type="protein sequence ID" value="BAV87020"/>
        <property type="gene ID" value="RA11412_0721"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0721"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="53" mass="5857" checksum="FA190F36A7C5A3C0" modified="2018-10-10" version="1">MNVVTLTPAGEELGLKADEKARAVEDLMSSEFTPQEQEQLRDLLGRLVEVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXI8</accession>
    <name>A0A2Z5QXI8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_05115</name>
        <name evidence="3" type="ORF">RA11412_0731</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87030">
        <property type="protein sequence ID" value="BAV87030"/>
        <property type="gene ID" value="RA11412_0731"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0731"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="215" mass="23716" checksum="0735C94CA1774A2B" modified="2018-10-10" version="1">MAEKKPAPGQRLPAAERREQMLNAASIVFGERGYTGATTDAVAKAAGVSQAYIVRTFGSKENLFAETASRAVDKTIDVFRTVAQGVESPQELLREMGHAYVKLVADRGILLTMMHLFTMGHHERFGQLARDEFMRIYRVLHHEVGMSPKATEKFLAKGMLINTVLGMRLTDVMKTDPDIQGFLACTFTQEEAESLAELAKHHTPLPPAARGRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXP3</accession>
    <name>A0A2Z5QXP3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">ilvD</name>
        <name evidence="17" type="ORF">I6I94_04740</name>
        <name evidence="16" type="ORF">RA11412_0814</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87113">
        <property type="protein sequence ID" value="BAV87113"/>
        <property type="gene ID" value="RA11412_0814"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0814"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAV87113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QQT89905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="614" mass="65439" checksum="EFF16DBDB3A3B339" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXR8</accession>
    <name>A0A2Z5QXR8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87248">
        <property type="protein sequence ID" value="BAV87248"/>
        <property type="gene ID" value="RA11412_0949"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0949"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="78" mass="8921" checksum="DD27E3CFD59A0135" modified="2018-10-10" version="1">MNVEYPSENDCSRLLTAAARARLQLQHMAESPLQSAIIESFFPEVMEHTQIKRVVASGYIDYYRIFVDRPVFSDPPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXS1</accession>
    <name>A0A2Z5QXS1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87255">
        <property type="protein sequence ID" value="BAV87255"/>
        <property type="gene ID" value="RA11412_0956"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0956"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="237" mass="26254" checksum="28D83C7BE0B6D9C3" modified="2018-10-10" version="1">MRECVYERDADMSGCTYYGRAAATECPGEQARFDASVYYGDVNYAGSVFCYHPDFTCSAYYGGADFGGCVYRRGLSVSGSAFHGPVNFGGSKCGKKSYCTSSVFTGPVTLTGTVFRKKVIFDESAFLASTDFSAADFSGRIPGFTECIFTPGEQYAFPQPVTSPPAGSRVLALWEVRRLDYFRQQVQAFTHPAVDDPEVLEAARQRVRVLKKQLHAWVFAMQDPRYQHPGFEKIRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXY1</accession>
    <name>A0A2Z5QXY1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6493 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87170">
        <property type="protein sequence ID" value="BAV87170"/>
        <property type="gene ID" value="RA11412_0871"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0871"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="2">
        <location>
            <begin position="45"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="407" mass="45017" checksum="0EEE0792BBF54040" modified="2018-10-10" version="1">MIHWHNNGFFRLAELYDGVQLEHNDDYFLALMNLNTPLRQALLRHDQQLRDELLWQLLTVEGTPENSLTNIDKFMPGTTWQEDLLTATHEGLIPKERLLDACLDALARDFAAYRAGWFSRMYTALTPTAAESAQRQGALVNLLGSSVGATVTLAVKQLLAVHRAGLLDTDRFIHGCAPALLTTKANALAVLKILESACATGGDGPVTELALTALGHTHPQVQVAAAQLLVRCNAAETLHQHAQSLSPVARQELEEAGLLTNTEEETAQHTAGLEESYPVPASPAQPVTPFSQQDAYARTLHAMQEAVQGLESELLFHWLMSENRDTSVLKPLTRQAEERIREHRAGHQIAYLILSALEPENSAVQEYEQHLAHEKTPVNQRIREIGERLRQNAHTPCWPPPQTPTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXY3</accession>
    <name>A0A2Z5QXY3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fumarate reductase iron-sulfur subunit</fullName>
            <ecNumber evidence="6">1.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I6I94_03925</name>
        <name evidence="9" type="ORF">RA11412_1028</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a menaquinone + succinate = a menaquinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:27834"/>
            <dbReference type="Rhea" id="RHEA-COMP:9537"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="ChEBI" id="CHEBI:16374"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="EC" id="1.3.5.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="6">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.4" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87327">
        <property type="protein sequence ID" value="BAV87327"/>
        <property type="gene ID" value="RA11412_1028"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1028"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="262" mass="29896" checksum="FD98C43CB633F36D" modified="2018-10-10" version="1">MAENELPEPESVKLFEGMTGGDGGAIPTYDVTIRVRRYNPEVSDEAYWDDFRLQMYRTDRVLDALHKIKWELDGSVSFRRSCAHGICGSDAMRINGRNRLACKTLLKDLDMTKPITVEPIKGLPCEKDLIVDMEPFFQAYREIMPFFINDSNEPERERLQTIEDRARFDDTTKCILCAACTSSCPVFWTDGQYFGPSAIVNAHRFIFDSRDDAGDLRLEILNDKEGVWRCRTTFNCTEACPRGIQITKAIAEVKQAILARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXZ0</accession>
    <name>A0A2Z5QXZ0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87337">
        <property type="protein sequence ID" value="BAV87337"/>
        <property type="gene ID" value="RA11412_1038"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1038"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="109" mass="12178" checksum="027AC18AC2230D36" modified="2018-10-10" version="1">MRIGAIDCGTNSIRLLIADAAVETDENGKETTRLKDVVRQMRIVRLGQGWTPPAGWRRRRWTALLRLPESTLSCLRSTVQTGCGSWRPVPPVMPVTVRFYGGYSADLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY33</accession>
    <name>A0A2Z5QY33_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87368">
        <property type="protein sequence ID" value="BAV87368"/>
        <property type="gene ID" value="RA11412_1069"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1069"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="40" mass="4476" checksum="720AA4B8546F2439" modified="2018-10-10" version="1">MSLFLCVYSNTVGCSECCSSTTPHREDIHVANSARKHLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY44</accession>
    <name>A0A2Z5QY44_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6 12">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RA11412_1079</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6 12"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87378">
        <property type="protein sequence ID" value="BAV87378"/>
        <property type="gene ID" value="RA11412_1079"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1079"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="13">
        <location>
            <begin position="7"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_4TMC" evidence="14">
        <location>
            <begin position="196"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV87378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="387" mass="43923" checksum="3FB288196FBF2C2A" modified="2018-10-10" version="1">MAYAAWLLFRSMTVATIAAILASVDGLMFVESRLALLDIFQMFWILATFVCLLLDRQQSRRVLARKVAALAQQNGGTLPQLVFGPGSGWHLWRLAAGVCAGAAVGVKWNSLFFIAAFGLLTVFWDVNARRILGLKNWAVVGVLREGLPAFVQMIGVGLIVYLSTWAGWFKSSNAFYRHWAQDNPGQGVQWLPTDLRSLWEYHVSAFNFHSKLDSPHSYASPAWKWLLLGRPTSYYYESPKMGSKGCTASSCSEAILNIGNPLIWWAFIAAILVALIVTIVRRDWRFTSLLFVFAVGYFPWFLYPNRTMFYFYALSFEPFLILILAGVLGLVLGHSGSSVRRKRVGLYFTGVYLVAVLLMSAYFWPLWTGQTIPYNEWLHHMWFSFWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY50</accession>
    <name>A0A2Z5QY50_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87388">
        <property type="protein sequence ID" value="BAV87388"/>
        <property type="gene ID" value="RA11412_1089"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1089"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_C" evidence="1">
        <location>
            <begin position="59"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="137" mass="14414" checksum="8CA3C7FB638D308E" modified="2018-10-10" version="1">MIPLDIVLVAASEGLSTPQVFSELDEGRAAGRYPEAGELQVPSGLLHALTQTETPIARIHEIGRQLRNDLQGPAVTLAPSLETILTMDNESIVEAFVSGSGPTVAILVEDAPAADELAAALRRRGRHAVATQTPAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYB4</accession>
    <name>A0A2Z5QYB4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">HMP-PP hydrolase Cof</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_03860</name>
        <name evidence="1" type="ORF">RA11412_1044</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87343">
        <property type="protein sequence ID" value="BAV87343"/>
        <property type="gene ID" value="RA11412_1044"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1044"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="313" mass="34143" checksum="5B2AE75056D45912" modified="2018-10-10" version="1">MPEIFAASSSANPRVTPRLIAVDMDGTFLTDAKTFDTDRFERILPRLQAHGIYFVVASGNTYTKLIDYMKGFENRGIIYIAENGAYLADDSGELAVHPFKEADVPHVYEVLDTLPQIGVILCTTEGIFIPRNRQGAVTSIVQDYFAAQGQPVPQGLDPYSFVLMFYPSAERITDYSQVRGELIKISVQTVRADTYSVLETLQRELPPQVIPLASGFGAIDLVREGVNKAGGLRDLCERLNVHPQEVLAFGDGDNDREMLAFAGTGVAMGHASQALRAVADEVIGSHNDGAVLTYCEELLDVLDVQSLPQAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYD8</accession>
    <name>A0A2Z5QYD8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Undecaprenyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87356">
        <property type="protein sequence ID" value="BAV87356"/>
        <property type="gene ID" value="RA11412_1057"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1057"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="5024" checksum="B28C1A0E75C5DB50" modified="2018-10-10" version="1">MTWQSAYSELYFCRALWPDFTRVDFLRALRDYAGRNRRFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYR1</accession>
    <name>A0A2Z5QYR1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03305</name>
        <name evidence="2" type="ORF">RA11412_1194</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87493">
        <property type="protein sequence ID" value="BAV87493"/>
        <property type="gene ID" value="RA11412_1194"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1194"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="256" mass="27588" checksum="E39CD85A4E0E5869" modified="2018-10-10" version="1">MNRQLRLMSFSLRQFLTVPYFLQLLLLSTFGATALQALAAGAWPVDATLAWTRAGIIGTWNMCIVAAGILNFERYRGTFVYLLNGAVNPLRALAAVVSTASIFGLAALPLAWVFWALCTFSVDFTDFTQVGARYLVGLPLLWVSCLAVTFVIAGFFVATPNAIAYEELLLVPVFVASGVLFTESSAPVWLDALGTLIPIQAPVKVLLGQMPVNSFGDFLGVVLQTCVVTAFWMLTGYLLGRRALRAATVHGTLGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYW6</accession>
    <name>A0A2Z5QYW6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87556">
        <property type="protein sequence ID" value="BAV87556"/>
        <property type="gene ID" value="RA11412_1257"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1257"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="367" mass="39583" checksum="47209E2C9B227A40" modified="2018-10-10" version="1">MGLFGASLLTIGVIQGMLPDMVAGASELLRKVLSFPPLLWIGQRSYGLYLWHWPLAVIAHYLYGPDRSPLINLLVLALTLAVAELSYRFVETPVRRYGFRGCARMVWQWLRTDRMKLVPLSITVAVIGACFASTAMAVHSAPQMTSAQTAVENGKKAAQERLQAKKEARASASASAAADPQQSQDPSAAPSPGPSGDSQPKVDSSQVTIIGDSIVVATQPDLYDTMPDAQVDAEEGRTIDKVIPIVKSMASNGQLRKTVVISVAANSTFAPGQLEQILETLPQDSKLVVVTGFGPSNLTWIENSNSIIREFAQKNSSRVVLADWNSTIREELQKNPTLMTSDGVHPDLSGQVIYARVITEAVAKAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ21</accession>
    <name>A0A2Z5QZ21_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">murG</name>
        <name evidence="13" type="ORF">RA11412_1403</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87702">
        <property type="protein sequence ID" value="BAV87702"/>
        <property type="gene ID" value="RA11412_1403"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1403"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="172"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV87702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="347" mass="37282" checksum="92D69406BB4A5DDD" modified="2018-10-10" version="1">MLAIAREIRKIEPTAKITMLGTADKLEAQLVPAAGFDIEFIPKAPLPRSLNKEAFAFPGRFLGGIRKAHEVFKQVDADVVVGVGGYVCPPAYMCAAKERIPIIIHEANAAPGWANKLGGRFAEFVGVAFPNTPFRGAELVGMPMSDEIANLDRKTQRSEAMRRLGLDESLPTVIVTGGSLGALTLNKAVEANIDALADWGFQVLHITGKGKAILDEQGNPRTAKNYHQMEFCTSMQDVYAAADLLVVRSGAATVSEVAAVGVPAVFVPLPHGNGEQSLNIRPLLEEGAARLVEDQDATAEWFASEIPALMADSALLERMAQKAYKLGIRDAARVMAERTLKAVKHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ67</accession>
    <name>A0A2Z5QZ67_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87738">
        <property type="protein sequence ID" value="BAV87738"/>
        <property type="gene ID" value="RA11412_1439"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1439"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="145" mass="15653" checksum="342BE61341578417" modified="2018-10-10" version="1">MTGPVHLPPHTSQVKSLAEMIRAILAAPKTGNWLGLDEILAGTGEKERSAVLRTLGGFTAVYEREGPTPRMFYLRAALAGRKKVGEIFTWPSANDPCTSWIARHPGTNYPVYSGEQLCTDASVREAAVEAFAAGILHRGARGFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ71</accession>
    <name>A0A2Z5QZ71_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87785">
        <property type="protein sequence ID" value="BAV87785"/>
        <property type="gene ID" value="RA11412_1486"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1486"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4389" checksum="74F201A72A158DAF" modified="2018-10-10" version="1">MNGRRAPRDSWASLGEAPLSSGWGGRKSPAAAAYERWNAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ94</accession>
    <name>A0A2Z5QZ94_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87782">
        <property type="protein sequence ID" value="BAV87782"/>
        <property type="gene ID" value="RA11412_1483"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1483"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="193" mass="21235" checksum="1CFA5EA9EA22FEDF" modified="2018-10-10" version="1">MDSHVYKKASFRLPALANIAVLRFNTRGTSSIRGTSDGVFDGGFAEKKDFDAILDYVLGRALPNPWLIGWSFGTELVLKYGPARANEFTGAVLLSPPLHRVHPAEMAEWNTISNPLYALIPEHDDYLQPAQARERFSAINRAQVIPFEGCKHLWVGEKSVNAVLNSIASIVLGEQTVLPSEYSGPVAEEITEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZC3</accession>
    <name>A0A2Z5QZC3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87798">
        <property type="protein sequence ID" value="BAV87798"/>
        <property type="gene ID" value="RA11412_1499"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1499"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="238" mass="27368" checksum="5D375AAE8688999C" modified="2018-10-10" version="1">MGMNKQCDDHQLSLWYTPRLDPPLPEHWGLNDQSRTELEELLWEMLLHGASTPEAYVEVFDYVLPDENAGLGEKYREEITEYAQQLINARRAYAAAIGLEPRNNDLTLAFDALAHEGVVARECFTCCGSCGSAEIWDERDDSRTWYGYVFYHEQDAESAYESGSVGLNYGVFLDAYFTEPQWDALDAQTQEQQYESLSVKLLREKVLPVFEQHGLWVDWEGSYSVRPQVFSSQFSHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZD7</accession>
    <name>A0A2Z5QZD7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87807">
        <property type="protein sequence ID" value="BAV87807"/>
        <property type="gene ID" value="RA11412_1508"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1508"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="35"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="251" mass="27291" checksum="47F6AECDD9CA8BF1" modified="2018-10-10" version="1">MRLTVIGCTGSFPGPNSPASCYLLTATDRHGRTWRVLMDMGNGALGVLQRHINLADIDAILISHLHPDHCIDLSGLHVAVKWDPRGWPAGRIPLYGPADINEYLSATHGLDPDPGMSTEFEYHTWTEGQKVRIGPFTVEPFRVIHPAKDPYALRIECNTATENILFAYSGDTDLCDGLIEAARGADLFLCEAAYQEGRDDALRGIHLTGKRAGQAAQAAGVRNLLLTHLPVWNDPDIARAEAKSVFTGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZG0</accession>
    <name>A0A2Z5QZG0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">glpK</name>
        <name evidence="10" type="ORF">I6I94_02620</name>
        <name evidence="9" type="ORF">RA11412_1361</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87660">
        <property type="protein sequence ID" value="BAV87660"/>
        <property type="gene ID" value="RA11412_1361"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1361"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
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                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
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                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VEI22879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="283" mass="29144" checksum="40C37A82C6F581AB" modified="2018-10-10" version="1">MSYQDAQPHAATYSVLDGAFPPANPGSALAARLRECQQAGRAALIGYLPAGFPTVDESVAAAIELGNNGADIIELGVPYSDPVMDGPVIQQATGTALDNGFKLTQLFDAVRRITEATNAVVVVMTYWNPVLAYGVDRFASDLAAAGGAGIITPDLVPDEASEWFEASEKHGLDRIFLAALSSSQDRLKTIAKASSGFVYAVSVMGVTGARASVSEAARSLVDDIRAAGAKHACVGLGVSTRAHVEEIGAYADGVIVGTALVKALQQGGPEAVGTLTRELAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZS9</accession>
    <name>A0A2Z5QZS9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CRISPR-associated protein Cas1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_1574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87873">
        <property type="protein sequence ID" value="BAV87873"/>
        <property type="gene ID" value="RA11412_1574"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1574"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="194" mass="21749" checksum="6A222E4C0F468BFC" modified="2018-10-10" version="1">MYAWRFPGEDTSQLTMQQLRGREGARVRRVYRYWSDKTGVPWSRRDYNPNDFGDSDPINQALSAGHACLYGIVHAAIVALGCAPGLGFVHTGHAWSFVYDIADLYKADITIPVAFQVAAAHEEGQDIGSITRRAVRDRIRGEKIMQRVARDIQRLLVPDEISDDTLEADVVALWNERGGDQKSGHNYSDDEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZW8</accession>
    <name>A0A2Z5QZW8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2469 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_01690</name>
        <name evidence="2" type="ORF">RA11412_1614</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87913">
        <property type="protein sequence ID" value="BAV87913"/>
        <property type="gene ID" value="RA11412_1614"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1614"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019592">
        <property type="entry name" value="DUF2469"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10611">
        <property type="entry name" value="DUF2469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="146" mass="16905" checksum="E5F17595CC593E89" modified="2018-10-10" version="1">MSAEELENYETDAQLALYREYRDVMSLFTHAVDTDRRFYLANHVEVIPRVSDGTVYFEVLMSDVWVWDVFRTNRFVKTVRVLSTHDVNVEERLPNQEFSIPDMGVRTLFDAAENTGMVSEAEHRPESNTQPQDASDARRRGPETDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZX3</accession>
    <name>A0A2Z5QZX3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgk</name>
        <name evidence="13" type="ORF">I6I94_01200</name>
        <name evidence="12" type="ORF">RA11412_1709</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88008">
        <property type="protein sequence ID" value="BAV88008"/>
        <property type="gene ID" value="RA11412_1709"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1709"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="363"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV88008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT89286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="407" mass="42607" checksum="A83266B939F2C846" modified="2018-10-10" version="1">MAKALAELLEEGVAGRHVLVRSDLNVPLKDGVVTDDGRVRASLPVIEKLAKAGARVIVTAHLGRPKGQVDPQYSIAPAAARLAELASVPVQVATDLVGEDAKAKSAALKDGEVLVLENVRYDARETSKDDAERGAFADELVALTGQNGAYVDDAFGAVHRKHASVYDVAKRLPAYLGDLVKKEVDVLAKTLNNPERPFVVVMGGAKVSDKLAVIDNLIGKADAILIGGGMGYTFAYAQGYKVGKSLLEKDQVETVRRYLETAPAQGTEIVTAVDVVWADDFSADAKTEIRPIEDLEGGELGAEGEGLDIGPKSRELFAEKIEAAKTVFWNGPVGVFEIAPFAGGTEAVAKALAESDAFSIIGGGDSASAIRNLGFADEQFGHISTGGGASLEYIEGKTLPGLDALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZY3</accession>
    <name>A0A2Z5QZY3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88018">
        <property type="protein sequence ID" value="BAV88018"/>
        <property type="gene ID" value="RA11412_1719"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1719"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="76" mass="8676" checksum="502D27E14051D043" modified="2018-10-10" version="1">MTAQHHTQPALPAQPTLQERRAHLRELMKHDDATVEDYHTVISGATEEERASLARTLSPTKLAKARGRKQLWPHMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZY6</accession>
    <name>A0A2Z5QZY6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphogluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88042">
        <property type="protein sequence ID" value="BAV88042"/>
        <property type="gene ID" value="RA11412_1743"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1743"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="1">
        <location>
            <begin position="19"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="256" mass="26815" checksum="020990DC90BD06D1" modified="2018-10-10" version="1">MPKINNIGESTPTLVAHPTREALAADAVGRIFDILEHVLTERTVAHVSLTGGTMGIATLRAWAASARVKDIDWSRVHFWFSDERFVPERDAERNDGQAIEALLADLTDYGFPVENAHRIGPSDVMIDVEAAAEHYAYEMRKFAGSADPVRVEMPEGASELPLVGGHGGAADSEPSGGGCGCGGCGCGGGSGSDSWPVPVFDVTLLGMGPDGHIASLFPGRQQVLLGTGLPEDPVDGAKAVTVMVKDSPKPPASGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R065</accession>
    <name>A0A2Z5R065_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1823</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88122">
        <property type="protein sequence ID" value="BAV88122"/>
        <property type="gene ID" value="RA11412_1823"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1823"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="22"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="364" mass="38410" checksum="5ED171E68E0D3561" modified="2018-10-10" version="1">MSVNVEALVAKVPTGLLIGSSWRPSSSDEVFDVINPATEEKLAAVSSATSEDAVAALDAACAVQQQWAATSPRERAEILRRAYELVIARADDFATLMTLEMGKPLAESHGEVVYGAEFLRWFSEEAVRDYGRYHPTPEGKNRVLVARKPVGPCLLITPWNFPLAMATRKAGAAIAAGCTIVLKPARLTPLTSQYFAQTMLDAGLPAGVLNVVPSASASAISEPLLADQRLRKLSFTGSTPVGKALLAAAAQNVLRTSMELGGNAPFIVFEDANIAEAVEGAMGAKMRNMGEACTAANRFLVHESVAEEFSARLAAKIGALKVGNGLDSDTTCGPLIEQKAVDSVSELVQDALERGARAIVGDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0A3</accession>
    <name>A0A2Z5R0A3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88162">
        <property type="protein sequence ID" value="BAV88162"/>
        <property type="gene ID" value="RA11412_1863"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1863"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="62" mass="7174" checksum="C366695B6EED8F78" modified="2018-10-10" version="1">MMNNDDAKDFFKQKAEKSSFSSEVSAADIFQEQKTYANKIPEDCSIWKEIYEEVSQILSTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0B2</accession>
    <name>A0A2Z5R0B2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87960">
        <property type="protein sequence ID" value="BAV87960"/>
        <property type="gene ID" value="RA11412_1661"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1661"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="71" mass="8355" checksum="68D6B4C0725A6CCF" modified="2018-10-10" version="1">MKWYRTGEYLTDGRMLVWEYPRETPDGEQIDILEFMIIEQGLIAQHRIYWGWKGCQHISGALASSVARVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0E0</accession>
    <name>A0A2Z5R0E0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-isopropylmalate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88235">
        <property type="protein sequence ID" value="BAV88235"/>
        <property type="gene ID" value="RA11412_1936"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1936"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="42"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="488" mass="54553" checksum="E50619337F5E0009" modified="2018-10-10" version="1">MNMQNRQTPSPMPVHKYRPFHEQIAVDLPDRTWPNKVATQAPRWCAVDLRDGNQALVDPMNTERKLAMFDLLVRMGYKEIEVGFPSASQTDFDFVRTLIEDGHIPNDVTIQVLVQCREHLIARTFEAIEGAPNAIVHFYNSTSVLQRRVVFQRDEDGVLDIALQGARLCKKFEEQMISNTNVLYEYSPESFTGTELEFAARVCNAVADELGVGVDGKELIVNLPATVEMATPNVYADAVEWMHRNLKNREHIVLSLHPHNDRGTGVAAAELGYLAGADRIEGCLFGNGERTGNVDLVTLGLNLYTQGIDPQIDFSDIDSIRKTVEFCNQLPVHERSPYGGDLVFTAFSGSHQDAIKKGFEALEASAAQQGKTIDEVTWEVPYLPIDPRDVGRSYEAVIRVNSQSGKGGVAYLLKSEYGLDLPRRAQVEFSQIVQERTDTEGGEMTPQKLWNIFTDEYLPALRIRNVGVSTVLSRLTLTRQIRGQPLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0H2</accession>
    <name>A0A2Z5R0H2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH hxlR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87974">
        <property type="protein sequence ID" value="BAV87974"/>
        <property type="gene ID" value="RA11412_1675"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1675"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="47" mass="5354" checksum="D7CE5CF706D6CA46" modified="2018-10-10" version="1">MPPRVDYALTPLGTTLTAPMNALRRWAQDHMVEVLAAREKYDQKNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0J0</accession>
    <name>A0A2Z5R0J0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88247">
        <property type="protein sequence ID" value="BAV88247"/>
        <property type="gene ID" value="RA11412_1948"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1948"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021447">
        <property type="entry name" value="DUF3097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11296">
        <property type="entry name" value="DUF3097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="182" mass="19854" checksum="C9D073E170814F95" modified="2018-10-10" version="1">MQNAPARVARASRIWVEGTHDAELVEKVWGHDLRVEGIVVEPLHGVDDLAAAIRSFSPTPGRRLGILVDHLIEGTKEQRIVAEALAVPGAAGNVKIVGHPFIDIWQAVKPAKLGLKTWPAVPHGEDWKKGTLRRLGQPHATQEDVANAWKRILSRVDSYTDLDPALLGPVESLIDFLTEPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0N2</accession>
    <name>A0A2Z5R0N2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catalyze</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88100">
        <property type="protein sequence ID" value="BAV88100"/>
        <property type="gene ID" value="RA11412_1801"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1801"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="161"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="414" mass="44102" checksum="DEECF73E05BEE2BD" modified="2018-10-10" version="1">MRELALAAGFDEAHVLSATYDDETGTQREGMPAVIASKPAAPGYPTILLYAHHDVQPTGERKLWQTDPFVATRKGERLYGRGAADDKAGVLLHLAAFRAVREVLGEHFKAGVKLFIEGEEEAGSPSFTSFISTYREQLAADYIIVADSANWRAGIPALTTSLRGVASGDIEVRTGSHAVHSGIFGGPYLDAHTVLARLIATLHTDDGTVAVNGLVRLNDSALEYAEEDFRADSGILDSVSLAGHGPITSRLWHQPAISVIGMDIPSIAESSNTLAALSRARISTRLAPGDTPEHAHQMLAEHLAAHAPFGAEVNYTPVDSGLPFAADTQQEGAQLALAAMRSAWEEEPVQTGMGGSIPFISDLKSVFPESQILITGVEDPDTRAHSANESLYIPDFKCGILAEALMISELCSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0P2</accession>
    <name>A0A2Z5R0P2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="7">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ruvA</name>
        <name evidence="9" type="ORF">RA11412_1914</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88213">
        <property type="protein sequence ID" value="BAV88213"/>
        <property type="gene ID" value="RA11412_1914"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1914"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="HhH1" evidence="8">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="8">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="175" mass="18551" checksum="BFA3AE5560AD1A4B" modified="2018-10-10" version="1">MIASLTGRVSHVGLDNVILDVNGFGMLVHATARTLAGLHLGETATVLTSMIVREESMTLYGFAEPAEREVFDMMLSVSGIGPRIALAVLSVHTASEVERAVATGDDKAFTKVPGIGPKGARRIVLELAGKLILSESQGEEAAAPRAGWHGNRRSLMPSPPWAGLKKTLMPRLTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0W8</accession>
    <name>A0A2Z5R0W8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Histone acetyltransferase HPA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00145</name>
        <name evidence="2" type="ORF">RA11412_1994</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88293">
        <property type="protein sequence ID" value="BAV88293"/>
        <property type="gene ID" value="RA11412_1994"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1994"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="169" mass="18395" checksum="D48002B869908A1E" modified="2018-10-10" version="1">MADAVERASTRLGLHKKKLRSSDIDILRESTLMNLNWPGERFTMQDLLDTAEFVRYIVMDARRGDYGVVACTSQGQWVGTARVLYLPQQNPGYGFVAPGIGELGVSVQPEARGVGLGTELICDVVEIARVRGDRGVSLSVETGNPARKLYEKLGFVDAGGSTGTMLLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R116</accession>
    <name>A0A2Z5R116_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">pyrF</name>
        <name evidence="10" type="ORF">I6I94_00610</name>
        <name evidence="9" type="ORF">RA11412_1875</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88174">
        <property type="protein sequence ID" value="BAV88174"/>
        <property type="gene ID" value="RA11412_1875"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1875"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="283" mass="29328" checksum="A9F109C044C1975E" modified="2018-10-10" version="1">MIPFGDRLAAAMDERGPLCVGIDPHPKLLQAWGLEDSAESLRTFTTAVYEGCAPYAAALKPQVALFERHGSAGLAVLEELFARAAEDRVLIVADAKRGDIGSTMKAYADAWLSTCSPLGTDSVTLSPYLGFESLRPALDAAAANQRGTFVLALTSNPEGKSVQHVGKTEDTGAVAKQIIAAATAENTAQTWERMGSCGLVVGATVGEALHDLAIDLSAFNGPILSPGYGAQGANAKDLYRVFAGVESQVLVNSSRGVLSAGPQVADLAQAAQMARADLVAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R126</accession>
    <name>A0A2Z5R126_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroB</name>
        <name evidence="11" type="ORF">I6I94_00560</name>
        <name evidence="10" type="ORF">RA11412_1885</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88184">
        <property type="protein sequence ID" value="BAV88184"/>
        <property type="gene ID" value="RA11412_1885"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1885"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="84"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="87"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="185"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="375" mass="41007" checksum="FCA036C02F030D7A" modified="2018-10-10" version="1">MTEANTAAFGASGGQDITYISVTGNAPRENYDVLVGHNLLSKIPEILGNQAKKILVIHPRALRSTGELVMEDLRKVGYQSFSAEIPDAEEAKHHQVAAFCWQVLGQNDFTRTDAIISVGGGAITDVAGFVAATWLRGVRVIHIPTTLLGMVDAAVGGKTGINTAEGKNLVGAFWPPAAVLCEIGTLRTLPEHELLTGMAEVVKCGFIADPQILDIIEGNPEKIRDSQSAVVRELIERAIRVKAEVVSEDLRESGRREILNYGHTLGHAVEHAERYQWRHGAAVAVGMVFAAELSLAAGYADEALVDRTRSILTSLDLPVSYRGDRWKDLLDTMRRDKKSRGAILRFIVLEGLARPRVYEVPDESILYMTYQEIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R127</accession>
    <name>A0A2Z5R127_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86579">
        <property type="protein sequence ID" value="BAV86579"/>
        <property type="gene ID" value="RA11412_0280"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0280"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="129"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="278" mass="29298" checksum="0DBFD235414A8871" modified="2018-10-10" version="1">MVWGSTYLITSEFLPPNRPFTAALIRVLPAGLLLLLITREFPRKNELGRIILLGILNIGLFQAMLFVSAYRLPGGLAAILSSTQTIFVLVLTRTVAKKATPASAWLAALMGIIGIILLVASPSTTFDVIGILAALTGAVAMACGIFFTSMGTSSLSTLAMTGWQLLVGGIFLLPIALLTEEPLPPLTAANIGGYAFLCLVGTALAYCVYFYGLLKLPPAVIASLGPLSPVTAFILGWIFLGQNMTPLSMLGFVLVLTSIVGVQRAMMGARKAALSHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R140</accession>
    <name>A0A2Z5R140_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rpsP</name>
        <name evidence="6" type="ORF">I6I94_11185</name>
        <name evidence="5" type="ORF">RA11412_2064</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887964.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88363">
        <property type="protein sequence ID" value="BAV88363"/>
        <property type="gene ID" value="RA11412_2064"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2064"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="144" mass="15982" checksum="08895AFB9F296A79" modified="2018-10-10" version="1">MAVKIRLKRMGKIRDPRYRVVIADSRVKRDGKTIEEIGIYHPTEQPSRIEINSERAQYWLSVGAQPTEQVLALLKLSGDWAAFKGEKAENKVKPVEPKPEFVVPQKGSVILPEAITPKAEKAEEETSEAAGETAEAEATEEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R156</accession>
    <name>A0A2Z5R156_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88221">
        <property type="protein sequence ID" value="BAV88221"/>
        <property type="gene ID" value="RA11412_1922"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1922"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="40" mass="4318" checksum="EBD96E308F5B6BB1" modified="2018-10-10" version="1">MIYNGETTRTAAPKVPSGPSHPADRKPTTKAADEPPHPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1B8</accession>
    <name>A0A2Z5R1B8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88291">
        <property type="protein sequence ID" value="BAV88291"/>
        <property type="gene ID" value="RA11412_1992"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1992"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="233" mass="26205" checksum="E75141BD874C4B79" modified="2018-10-10" version="1">MFSVPGVRAKKFFHPTLDIPNSRFYIVIMAADKTANSKSKGQLTREHILEVAAQVFAQRGYSETRLDDIIQATGLTKGALYFHFRSKSDLAYAVIEDHKRHWLEQGIQEIAQHDNPLEQLEALSNLLITLVSQGKTDWNIVRLADQVRSKEPPEDLISPLQSWVDVVADIIERGKAQQIFHTELSSQDAAAILVGSFDGLKTSNDALAQGDTEKFRRQAHALNTMLIEGLQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1C2</accession>
    <name>A0A2Z5R1C2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galactofuranosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88585">
        <property type="protein sequence ID" value="BAV88585"/>
        <property type="gene ID" value="RA11412_2286"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2286"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040492">
        <property type="entry name" value="GlfT2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17994">
        <property type="entry name" value="Glft2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glft2_N" evidence="1">
        <location>
            <begin position="56"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="471" mass="52533" checksum="294A6F04AE19A136" modified="2018-10-10" version="1">MTTEEKTLKTLQRVIFPSAVETDVVPLYVDAGAATGVQLPTRFDSDAATSLKEATDAQTLNAPAPAASANAARNLTGRRSITVGDGKHLSFGTYFNAFPASYWRRWTDLKQVVLSVHTSGEGMVVVYKSNGRGVIQRVDAKLLSGSAETTFQLPLAPFGDGGWYWFDLSGTTDLELIEANWLGDIEPRADVNAGQATVQITTMNKVEYCINNIRTLGESPEIFDSVHEFLIVDQGNKKVQDHPDFEEVVKPLAGKFRIINQGNLGGSGGFSRGMFEAVNNGSDYVLLLDDDVIVEPESILRMVTFANYCKTPTIVGAHMFDMFDRSVLHAYGEVVNPWRNFYDKPYDDMVMGHDLGRSNLRSTHWLHRRVDVDYNGWWMCLIPTAVIHEIGLSLPLFLKWDDAEYGLRAKEAGFPTVSFPGAGVWHVSWTDKDDSVGWQAYYHERNRLITALLHSPFDKGGRVMLDSLFWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1D1</accession>
    <name>A0A2Z5R1D1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88488">
        <property type="protein sequence ID" value="BAV88488"/>
        <property type="gene ID" value="RA11412_2189"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2189"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="349" mass="39723" checksum="FA61939CD732192E" modified="2018-10-10" version="1">MCLPLRKTAPFKTHNLIKTDNRESCAARLVPDDTSGAVPSGRGWVVCGEKPNHEKNIRYYVYAVVALALLGMCFLLPGSSVFHQGAWLTVILGLLAPVVNRLWAFKAVRRVYWHPLNRAARTVLVAVYGLLVLELFRPWEAPDGFATTAVRLGAPLVYVFLIAPIVTFLPYYPVRYWVLGQLRTPTVAPHSRDFFGVSPRTAVAYLDAPLHKLNAEQGRERAYSYVWCADRAMRTVQNRLTVEAVREPITEETTERVERLQQLVERAYQRCDSMDRHEPGSQAYLQERAQAMANSYVVLTSVGSPAWGWGSGTTRLWTRHAGRYCTRTCRRYTTVLSRRRRRRVKPCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1E6</accession>
    <name>A0A2Z5R1E6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">ftsY</name>
        <name evidence="9" type="ORF">I6I94_11135</name>
        <name evidence="8" type="ORF">RA11412_2071</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88370">
        <property type="protein sequence ID" value="BAV88370"/>
        <property type="gene ID" value="RA11412_2071"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2071"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="7">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="174"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="257"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="319"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT90175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="367" mass="38657" checksum="1F07B3B9BA9709B4" modified="2018-10-10" version="1">MWIILAIVLGVLVLIGVLFAFLRSPKAPRGGYPSTRDADDTGGAKEPEGEEPQEPGVETPAPVAGRLVRLRARLARSNNMLGKGLLALLSRDRIDQDVWDEVEETLLMADLGAEPTTRLVEALQKRVRVEGTDNPAAVKKMLHEELLEIIGPTMDRELKTEGTDGNPGVVLVVGVNGVGKTTTVGKIARVMVADGNSLLLGAADTFRAAASEQLTTWGDRVGVKTVRSEKEGADPASVAFDAVKTAKAEGIGTVLVDTAGRLQNKAGLMDQLGKIKRVIEKEAPVTEVLLVIDATTGQNGMVQAKVFGEIVDVTGIVLTKLDGTAKGGIVVAIQEELGVPVKLVGLGEGPDDLAPFDPEGFVDALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1I0</accession>
    <name>A0A2Z5R1I0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88538">
        <property type="protein sequence ID" value="BAV88538"/>
        <property type="gene ID" value="RA11412_2239"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2239"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="344" mass="37555" checksum="5BA1B3AB7CFD713A" modified="2018-10-10" version="1">MHFEYFRYKRYMENIEYLNLLTEDARRTIWRVEYCPKPSDNAPSTAQTGEHPLGLKPGIYTLMRLNAADDSALAEALCSLEPNPGLATLLAVQHLTGTAEAAQKIESAGTLQWYEPLEAGTLSALLAAREHIPVAEVASLARSLCEGLAHLHHQGFIHGAISTENVLISTHGTPKLIDTRHAPGNLSTSALSLAQAEDTRALARLLWHALTGKPPAAAHERIPLPLAAEDITENMGYTLENVLDTDLPSLETIVEVFSKVQAVPLNAYLSAPEDVRERMPAASNQQQGSKSKPVQNAPAAKARPKEPKARQESSNKPQKKSSKPPRTVCCLVHSLSLLQWVLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1J5</accession>
    <name>A0A2Z5R1J5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88371">
        <property type="protein sequence ID" value="BAV88371"/>
        <property type="gene ID" value="RA11412_2072"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2072"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="46" mass="5269" checksum="0FCCD147BA4CACA2" modified="2018-10-10" version="1">MPDALVGGRELVLVCWRFLQSLVYSCPGFICTIHLLETLCWESVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1J9</accession>
    <name>A0A2Z5R1J9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RA11412_2234</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88533">
        <property type="protein sequence ID" value="BAV88533"/>
        <property type="gene ID" value="RA11412_2234"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2234"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="5"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="335"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAV88533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="454" mass="47907" checksum="56DA004848BE6772" modified="2018-10-10" version="1">MAQEFDILILGGGSAGYATALRARQLGFSVGLIEKDKVGGTCLHTGCIPTKAYLHAAELAEDAREASKVGVNTELQSIEMGKVRNYKDGIVGGKFKGLSGLLKMKGVEVINGEGKLTGKDTITVNGTEYKGKNIVLASGSVSKTFGLPIEGRVLTSTEALEMDYLPNSAIVLGGGVIGCEFASMWKAMGVDVTIIEGLPNLVPNEDPSIIKVLERSFKKRGIKFNTGTLFEKVEQDANGAKVTLADGKVFEADIVLVAVGRGPNTAGMGYEEQGIPMDRGFVLANERLHTGVGNIYAVGDIVPGVQLAHRGYQQGIFVAEEIAGLNPSVVEDVNIPKVTFCDPEIASVGYSEPKAKEKFGADNVEVAEYNLAGNGKSSILGTGGIVKVVREKNGPIVGVHAIGKRMGEQIGEAQLWVAWEAFPEDVAKFIHAHPTQNESLGEAAMALNGTPLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1L1</accession>
    <name>A0A2Z5R1L1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">smpB</name>
        <name evidence="5" type="ORF">NCTC10207_01526</name>
        <name evidence="4" type="ORF">RA11412_2269</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88568">
        <property type="protein sequence ID" value="BAV88568"/>
        <property type="gene ID" value="RA11412_2269"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2269"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI23418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <sequence length="173" mass="19797" checksum="F1B55D2C81ABA55D" modified="2018-10-10" version="1">MRNIQLEDMMAQKKKKGVKDPNNSIIAQNKKARHNYNIVETYEAGLVLMGTEVKSLRDGGASITDGFCQVNGNEMWLEGIHIAEYGYGTWTNHAARRRRKLLLHRTEINRLGQKLKETGYTVVPLKLYFSNGRAKVEIALATGKREYDKRQALRERQDTLEAARAMRYRNLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1L7</accession>
    <name>A0A2Z5R1L7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc ABC transporter ATP-binding protein ZnuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88553">
        <property type="protein sequence ID" value="BAV88553"/>
        <property type="gene ID" value="RA11412_2254"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2254"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="215" mass="23292" checksum="129F5B57EC756869" modified="2018-10-10" version="1">MRARDLVGLGVDGHRWGIRLSGRKYRAKVDELLEAVGATEYANVPVGLLSGGEQQRLRVAQALANDPKILLADEALLSLDLNHQYAVAELIHRFNRDHGLSVVFVTHEINPIIEHVDRVLYLANGRFTVGAVDEVMQTQTLSELYGTPVNVLKSNGRYVIVGQGHSGGTHLVEEETAGLTARDTHEGEATNAPTNPAHSSNQTINTKSIHPGGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1N7</accession>
    <name>A0A2Z5R1N7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88424">
        <property type="protein sequence ID" value="BAV88424"/>
        <property type="gene ID" value="RA11412_2125"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2125"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="73" mass="8056" checksum="254234B0F127B5C6" modified="2018-10-10" version="1">MEPASYFCPVASVDALAEAELVCEDDVSEADDELPDVDVLLWLQAASRDAEPKPRRATAPLRVTDKDMFLPFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1U5</accession>
    <name>A0A2Z5R1U5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec-independent protein translocase TatB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Twin-arginine translocation protein TatB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09935</name>
        <name evidence="2" type="ORF">RA11412_2379</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037234899.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88678">
        <property type="protein sequence ID" value="BAV88678"/>
        <property type="gene ID" value="RA11412_2379"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2379"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="123" mass="14222" checksum="D6B4688AEA9C4997" modified="2018-10-10" version="1">MFGISGLEFIVLVVLTFFVIGPERMPEYARQAKEFIKTVRRMAFDAKDDFKDALGDTGLDDINWRQYDPRQYDPRVIVREAFAEDDAERAREAKEREEKNKPVASNITRLPRGAYAPFDTEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1X1</accession>
    <name>A0A2Z5R1X1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Restriction endonuclease subunit S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_09635</name>
        <name evidence="5" type="ORF">RA11412_2446</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="162539">
        <property type="entry name" value="S.Rae11412ORF2447P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88745">
        <property type="protein sequence ID" value="BAV88745"/>
        <property type="gene ID" value="RA11412_2446"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2446"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="187"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="353" mass="38940" checksum="1EB0894854F58190" modified="2018-10-10" version="1">MSVLETLDFQPMLIVDMFRPHKGKRLVAAHRQPGKTPFVGGSESYNSITGFSDVDPLFPGGWITLVYNGSVGQTRLQPAPFFASDDVIALEPIAKNVSEAALLVCCAIIQRECVNKYSYGSKLNLQRLNRQTVMVPTTVGSDGTIEANWDGMDRLGAELLDQVVTHTHSARETRLADDDTLPELRFEPMFITDVFDSMKASRAWYDKVHLAGGQGRNLYLSQTLGGNSVSAVVADQDSRPEPGNCITVTLKTQSTFYQPAPFYTAQNFLIFRHRNLDANSGLFLVTTMRDAMNKFSWGYGVSMVRLQKTRIMVPVVTDISGEDVVDWKGMASYGRALRVRAERAIAPVVGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1X9</accession>
    <name>A0A2Z5R1X9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88481">
        <property type="protein sequence ID" value="BAV88481"/>
        <property type="gene ID" value="RA11412_2182"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2182"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="116" mass="12234" checksum="C9C53A5AA94DF620" modified="2018-10-10" version="1">MRRALTGGPVDSRQLAATSLPKRYALPLLGSDGISSVAYAADEVILILAVAGAGALTYSPWVGFAIAVVGLVIVEPTGITSGRSQLRAISPWYAANWAAARPWCWAPPCCWTMCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Y1</accession>
    <name>A0A2Z5R1Y1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component system response regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Response regulator protein vraR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Response regulator transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vraR_1</name>
        <name evidence="6" type="ORF">I6I94_09585</name>
        <name evidence="7" type="ORF">NCTC10207_01676</name>
        <name evidence="5" type="ORF">RA11412_2456</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023134161.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88755">
        <property type="protein sequence ID" value="BAV88755"/>
        <property type="gene ID" value="RA11412_2456"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2456"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VEI23686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="210" mass="22295" checksum="9ED57605CCE77078" modified="2018-10-10" version="1">MIKIMLADDQQLVREALAALLGLEHDIEVVAQVGGGDEVLPAIHRYHPDVVLLDIEMPGSELSSGIDVAAAIRDAKLVALTGEPVRSLILTTFGRPGYLRRALDAGASGFMVKDTSASQLAEGIRRVNMGLTVVDPSLAADSLLHGESPLTERETEILRATRDGATARQIGATLFLSPGTVRNHLSSAMAKLNASNRQEALNIAADNGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Z3</accession>
    <name>A0A2Z5R1Z3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88496">
        <property type="protein sequence ID" value="BAV88496"/>
        <property type="gene ID" value="RA11412_2197"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2197"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021443">
        <property type="entry name" value="DUF3093"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11292">
        <property type="entry name" value="DUF3093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="111" mass="12366" checksum="07AAF6D17591A524" modified="2018-10-10" version="1">MGVIAGAVVSAVLGWLLYASSPVIEVSAEWVRVGRARIEREYIGRVQAFRGDDARRAAGPELDGRAYMCFRPWVTPKVRLQITDPADPTPYWLASSRHPEKLVQLLDTAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Z8</accession>
    <name>A0A2Z5R1Z8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88713">
        <property type="protein sequence ID" value="BAV88713"/>
        <property type="gene ID" value="RA11412_2414"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2414"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025971">
        <property type="entry name" value="LppP/LprE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14041">
        <property type="entry name" value="Lipoprotein_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="94" mass="10085" checksum="1097D2D25DA861BD" modified="2018-10-10" version="1">MSLSDTSNYDANVELSWIVVGAQGGTDGPYHIMLFHYGEYLGTGTYDPLYGKPNVSRTAANQISATHSADKASFTWDDSQGKIVMSGHLPTVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R215</accession>
    <name>A0A2Z5R215_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="2">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88516">
        <property type="protein sequence ID" value="BAV88516"/>
        <property type="gene ID" value="RA11412_2217"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2217"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="4">
        <location>
            <begin position="178"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="404" mass="45016" checksum="AE7A5AAE0A884EDD" modified="2018-10-10" version="1">MERECEVDIALRWGIGYETTIRSFVNIIATPKGGTHTTGFEQGLLRTFRKHLADNARRFKVGNDKIEKDDALAGLTAVLTVRLAEPQFEGQTKEILGTPAVRQIVLKVVSDQLKARLQATGRADKAQANALCEKVVSEMKTRISARVHKEAQRRKTALESSSMPTKLVDCRSGNVEHSELFIVEGDSALGTARLARSSSYQALLPIRGKILNTQRASVSDMLANAECAALIQVIGAGSGRTFDLQAARYGKVIMMTDADVDGAHIRTLLLTLFYRYMRPLIEDGRVYAAVPPLHRVEVINRGKPNEMVYTYSERELHELLDRLTAEGKGYKEPIQRYKGLGEMDADQLAETTMDPRHRMLRRIRVEDAEAAERAFALLMGSEVAPRKEFIIAGAHQLDQENIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R266</accession>
    <name>A0A2Z5R266_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Histidinol-phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisN</name>
        <name evidence="4" type="ORF">I6I94_10400</name>
        <name evidence="5" type="ORF">NCTC10207_01519</name>
        <name evidence="3" type="ORF">RA11412_2267</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.15" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023134019.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88566">
        <property type="protein sequence ID" value="BAV88566"/>
        <property type="gene ID" value="RA11412_2267"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2267"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI23412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="273" mass="29453" checksum="C952944341712215" modified="2018-10-10" version="1">MNTTPYTDDVRLAHTLADSVDRVAMARFTDHSMSVHMKDDGTPVTDADREIEQLIRAQLQRARIRDGVAGEESGTMGTTSRQWVIDPIDGTSNFVRGVPVWATLIALLDEGEPVVGLVSAPALQRRWWAAKGSGSYAGKSLARATRLEVSKVANIANSSLSYSDFAGWAENGMEQRFFSLAQSVKRTRAYGDFWSYCLVAEGAVDIAADPQLNMHNVAALVPIVREAGGKITTFNGNNATSTTYSQRTSVLATNGALHSKAQGLLSDIGISED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2A5</accession>
    <name>A0A2Z5R2A5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">mnmA</name>
        <name evidence="9" type="ORF">I6I94_10210</name>
        <name evidence="8" type="ORF">RA11412_2307</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88606">
        <property type="protein sequence ID" value="BAV88606"/>
        <property type="gene ID" value="RA11412_2307"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2307"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="399" mass="43336" checksum="E2727D582FED90F1" modified="2018-10-10" version="1">MKILAAMSGGVDSAVAAARAVDAGHEVVGVHLALSRMPGTLRTGSRGCCTLEDSMDARRVCAQLGIPFFVWDFSERFKEDVVDDFIAEYEAGRTPNPCMRCNEKIKFAALLEKAVSLGFDAVVTGHYARVITNDDGNRELHRAADWAKDQSYVLGVLTHEQLKHAWFPLATTPSKAEVREEAARRGFSVAKKPDSYDICFIPEGDTRAWLGEHIQMRPGLIKDTSGTVLGEHPGAQAYTVGQRKGLALGTPAPDGKPRFVLEIRPKTNEVIVGSRELLAVDEIRGIRATWAGVPVAEAAEFMGQDPKLGACSATFEVTAQVRAHADPVRGTAHLQWVENTDENTEGQLRLETVVRLKDGLSGVAPGQTMVLYQGTRVLGQSTIARAYSLAREDIRQTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2G0</accession>
    <name>A0A2Z5R2G0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88945">
        <property type="protein sequence ID" value="BAV88945"/>
        <property type="gene ID" value="RA11412_2646"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2646"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011534">
        <property type="entry name" value="Asp_ADH_gamma-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46278:SF4">
        <property type="entry name" value="PTHR46278:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dhC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="112" mass="12158" checksum="B8EB34BEE6CF9D0F" modified="2018-10-10" version="1">MIMDGLCVRIAAMRSHSQALTMKLTEDLPVAEIERIIAEDNQWAQVVPNTKDATMEGLTPVAASGSLNIPVGRIRKLAMGPQYISAFTVGDQLLWGAAEPVRRMLKIAVGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2G7</accession>
    <name>A0A2Z5R2G7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">rplA</name>
        <name evidence="12" type="ORF">I6I94_08895</name>
        <name evidence="13" type="ORF">NCTC10207_01823</name>
        <name evidence="11" type="ORF">RA11412_2619</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88918">
        <property type="protein sequence ID" value="BAV88918"/>
        <property type="gene ID" value="RA11412_2619"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2619"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="3 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV88918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT88629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VEI23955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="231" mass="23965" checksum="2F664EB216728961" modified="2018-10-10" version="1">MAKRSKAYKAAVAKIEEGKLYTPAEAVALAKETSSAKTDATVEVALRLSVDPRKADQMVRGTVNLPHGTGKTARVVVIAAGDKAAAAEAAGADYVGSDELIAKIAGGWTDFDAAVATPDMMGKVGRLGKVLGPRNLMPNPKTGTVTMDVAKAVADIKGGKIDFRVDRNSNLHFIIGKASFSAEQLAENFAAALEEVNRLKPSSAKGRYISKATIATTFGPGIPVDPAEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2L9</accession>
    <name>A0A2Z5R2L9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AzlC family ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Branched-chain amino acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I6I94_09810</name>
        <name evidence="10" type="ORF">RA11412_2407</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88706">
        <property type="protein sequence ID" value="BAV88706"/>
        <property type="gene ID" value="RA11412_2407"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2407"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT88806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="291" mass="31327" checksum="D82FE80756CC1331" modified="2018-10-10" version="1">MKDTAKETSDAEHYAAIGHNPTESGFKQALRASSVVLASFVVLGLGLGVIISAHHLPWWLAPAISLIVYAGSVEFLVVEMIATGASVGAIGFTTLLVNSRHLVYGISFPLQNVKGFWAKLYAIYTLCDESYALNTGPDRNTLSHARILWVSTFLHISWVAGTTAGFFIGASFLSHLEGMDFAMTALFTILAIDAYRAQRDNVTALLTLFSGAVGIILAPGSMLLVSMGTYTALLIVRFFIAKSRGTLPEHQIPAPENNTAVTAAEDSTTDQVKTSSLTFTHHNDPQENPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2S3</accession>
    <name>A0A2Z5R2S3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89065">
        <property type="protein sequence ID" value="BAV89065"/>
        <property type="gene ID" value="RA11412_2766"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2766"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV89065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="257" mass="28445" checksum="D321F43B257EA5B9" modified="2018-10-10" version="1">MTPQKEGASMVQRQFPKPSELMEFMQFKKPSLDFTGNRLEKALTIYDLRKIAKRRTPAAAFDYTDGAAEGEFSMNRARQAFEDIEFHPGVLTDVSTVDTTTEVLGGTSAMPFGIAPTGFTRLMQTEGEIAGSGAAGAAGIPFCLSTLGTTSIEDVRKVNPDGRLWFQLYVMREREISYGLVERAAKAGFDTLFFTVDTPVAGARLRDKRNGFSIPPQLSLKTVANAIPRPWWWYDFLTTPSWNSPRSPQPAVPWASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2T2</accession>
    <name>A0A2Z5R2T2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MarP family serine protease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Serine protease Rv3671c</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_04430</name>
        <name evidence="8" type="ORF">NCTC10207_00369</name>
        <name evidence="6" type="ORF">RA11412_0900</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888467.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87199">
        <property type="protein sequence ID" value="BAV87199"/>
        <property type="gene ID" value="RA11412_0900"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0900"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI22294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="394" mass="41128" checksum="D95CB284244DC2FA" modified="2018-10-10" version="1">MFANLSPLDIIIPIILVLYFLMGLRSGFFTTLGTFLGLALGVCAAAWLVPLAVAAVSPQWMLPTAIGLLLLCLVIGQWLGVIAGRSIRKVTDVTPIKGVERFFGGVLNVAACALVLVVITLSMRTVPIPSVNTALGESKTLTWMVEATPSAVKDRIDSVRNDVLTAGSIPEVKQLLYPETNAPTQQVQSDALENASSSVVQILGAAEQCGYTSTGSGFVAGQDLVVTNSHVLSGVTSPTVQDSRGRTYPGTVVYNNPAQDLAFIRVPRLPIQPLQVANTNSESGETVTFMGYPKGGPFAAKPATVQGVGNIQTIDSETGKANPTRQVYQIAADVQHGNSGGPMLTQDGTVVGVVFAKATEGQTGYAITASTLKQALAANGNNTTPVSTGQCKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R333</accession>
    <name>A0A2Z5R333_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88881">
        <property type="protein sequence ID" value="BAV88881"/>
        <property type="gene ID" value="RA11412_2582"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2582"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="52" mass="5838" checksum="E741A503F9F27C56" modified="2018-10-10" version="1">MSAQKATPKDGIHTAIDSFARVPESSRHPRNSGHPSTEAKYFDIRLYRLKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R345</accession>
    <name>A0A2Z5R345_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-guanine dinucleotide biosynthesis protein MobA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NTP transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08950</name>
        <name evidence="2" type="ORF">RA11412_2607</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88906">
        <property type="protein sequence ID" value="BAV88906"/>
        <property type="gene ID" value="RA11412_2607"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2607"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="8"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="205" mass="21488" checksum="D76388CFA10A8393" modified="2018-10-10" version="1">MHTPGFCAIIVAGGKSSRLGNTPKAGLSNGTHTLLDRALLAVSQADACVVVGPETLPVPNDVLLTREDPPYSGPAAAIHAGAEKLAQHYSGIGRPAPTWCIILGVDTPNIAPAVSLLAEHAGAAAGHETGFWGVCDGVYQPLVGIYRYAPLRQVFSAGSTNASVRSFLKQLHPQEVELSPAHTADVDTWEQARALGFDSPQWSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R359</accession>
    <name>A0A2Z5R359_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89020">
        <property type="protein sequence ID" value="BAV89020"/>
        <property type="gene ID" value="RA11412_2721"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2721"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="537" mass="58688" checksum="633F2BF6FBBB3D19" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R395</accession>
    <name>A0A2Z5R395_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpsN</name>
        <name evidence="6" type="ORF">I6I94_08195</name>
        <name evidence="7" type="ORF">NCTC10207_01968</name>
        <name evidence="5" type="ORF">RA11412_2791</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006889130.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89090">
        <property type="protein sequence ID" value="BAV89090"/>
        <property type="gene ID" value="RA11412_2791"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2791"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV89090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VEI24219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="101" mass="11725" checksum="EE701FF63521E89A" modified="2018-10-10" version="1">MAKKSKIARNEQRKVIVARYNEKRLALKKTLIDENATPEEREAARVALQKLPRNASPVRVRNRDQIDGRPRGTFQKFGISRVRFREMAHRGELPGITKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3I2</accession>
    <name>A0A2Z5R3I2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">pheS</name>
        <name evidence="16" type="ORF">I6I94_02830</name>
        <name evidence="15" type="ORF">RA11412_1310</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87609">
        <property type="protein sequence ID" value="BAV87609"/>
        <property type="gene ID" value="RA11412_1310"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1310"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="149"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV87609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QQT89568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="375" mass="42087" checksum="7F8A991AB505FE25" modified="2018-10-10" version="1">MTDPVQETENVPESAHTLASIAQILNENPESGLEIVRAAFDAERERALTALRERAKDFESLKTVRLGFFGDKGSMSLANKQMRDLQNQHKGPVGKLLGQARAALTEAIEARTAELEAEREARILEEEAVDVTAASARRSLGGRHPVALMQEKLTDIFVGMGWEVADGPELESEWYNFDALNIKPDHPARDMQDTFYIEPREAHLVLRTHTSPVQMRAMLTRELPLYVVCPGQVYRTDELDATHTPVFHQIEGLAVDKGLTMADMKGTLEYMARAMFGEEARIRLRPNFFPFTEPSAELDLWHPNAKGGPQWIEWGGCGMVNPNVLRAAGIDPEIYSGFAFGMGIERTLMFRNNVPDMHDMIEGDIRFSEQFGMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3U9</accession>
    <name>A0A2Z5R3U9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">tpiA</name>
        <name evidence="6" type="ORF">I6I94_01195</name>
        <name evidence="7" type="ORF">NCTC10207_01067</name>
        <name evidence="5" type="ORF">RA11412_1710</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887348.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88009">
        <property type="protein sequence ID" value="BAV88009"/>
        <property type="gene ID" value="RA11412_1710"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1710"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VEI22971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="258" mass="27743" checksum="EBF5E606AD86C87E" modified="2018-10-10" version="1">MSRKPLIAGNWKMNLNHIEAVTLVQKLAWTLDDANFDFDKTEVAVFPPFTDIRSVQSLIEGDKFRIEYGGQDISAHDSGAYTGEISGSFLAKLNAAYVLVGHSERRTYHGETDEVCAAKVQAAYRHEITPVLCVGEGLDIREAGNHVTYTLEQLRGSISGLTAEQAKSLVIAYEPVWAIGTGKVATAEDAQEMAAAIRAELTKLYSADVANQVRVLYGGSVKSSSAPSIMEQADVDGVLVGGASLQADEFAAIARFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R465</accession>
    <name>A0A2Z5R465_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88329">
        <property type="protein sequence ID" value="BAV88329"/>
        <property type="gene ID" value="RA11412_2030"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2030"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="4705" checksum="277464C7B087BC7C" modified="2018-10-10" version="1">MRRDIELVSPGTTVAAPLVNSHDTASARIIAACALNRVMEALRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4B8</accession>
    <name>A0A2Z5R4B8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88459">
        <property type="protein sequence ID" value="BAV88459"/>
        <property type="gene ID" value="RA11412_2160"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2160"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="39" mass="4188" checksum="C9558193AB48A7DB" modified="2018-10-10" version="1">MADWLGMAEGDIIASELIMAEEEGADDAEELDDALGDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4T1</accession>
    <name>A0A2Z5R4T1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6 8">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glmM</name>
        <name evidence="14" type="ORF">I6I94_09270</name>
        <name evidence="13" type="ORF">RA11412_2530</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6 8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88829">
        <property type="protein sequence ID" value="BAV88829"/>
        <property type="gene ID" value="RA11412_2530"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2530"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="161"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="262"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="378"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV88829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT88702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="453" mass="47154" checksum="F87937232EF7920E" modified="2018-10-10" version="1">MTERLFGTDGVRGLANSAITPEFALELAQAAAIVLGFDTVADGVRPRAVIANDSRASADFICAAMKAGFASAGVDVLDAGVVPTPAAAYLVAHTDADFGVMISASHNPAADNGIKFLARGGQKLEDKVEDAIEHVYKLKAFRYPTGGAVGTVRPLSNGASVYVDHLVSTLSEEKPLAGQKIVLDCANGAAYSVSPAAFEALGAEVVTLAVEPNGTNINDGVGSTHPEKLQEAVIKHGADMGIAHDGDSDRCQAVDENGKLVDGDQIMAILAVAAKNAGTLAQDTLVATVMSSLGLELYLKEHDINLVRTGVGDRYVLEAMRENGYNLGGEQSGHVIMSDYATTGDGVLTGLHLAAEVARSGKKLSELAARMKPTPQRLINVKNVDRAGVKTNKALTAAVTDAEKTLGHSGRVLLRASGTEPLVRVMVEAAAQQQADEVAQQLADVVTKELKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R526</accession>
    <name>A0A2Z5R526_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Copper resistance protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_2770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89069">
        <property type="protein sequence ID" value="BAV89069"/>
        <property type="gene ID" value="RA11412_2770"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2770"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV89069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="484" mass="53573" checksum="2593D6F7B1F75CC4" modified="2018-10-10" version="1">MSIWCGGLIALAFISRGISGKDAGTGTVVEERRGEHTAASRRVPMAHAVLRRYSLLALIGFILVLLSGITNAGVRMSSWRDLGTDYGKIVLLKLGLTLILGTIGAAHRLRLIPALAAGKMSGTRALWSAIAAELVIMGAASGLGASLSRTPPPVPETLAPDATPVRIITWYDMPPEPHFQRWFTEWRWDWFWVAALGYLAIVYLWAFVKVRHAGDSWPVMRAVSWMLGLLVLNYITSGPPAVYSRVLFSVHMFEHMVLTMVVPILLVLGAPVTLLLKALEPRQDGTRGPREWIVRIVHSGWSKVVTHPIFAAVNFAGSIVVVYFTPLFGVMLRYHIGHEFMMIHFTLTGYIFMLVLIGIDPIPHRPQYPMRLIMLIATLGYHAFVGISIMNSKALLAASWFGNLGRTWGLSALDDQKMGGALMWGIGEIPTMIVAVAVGFQWAKADKKLAARIDRQADRDGDAELNAYNEMFERLHEEDTRRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R533</accession>
    <name>A0A2Z5R533_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein HB1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DNA-binding protein HU</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">HU family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hup</name>
        <name evidence="3" type="ORF">I6I94_08200</name>
        <name evidence="4" type="ORF">NCTC10207_01967</name>
        <name evidence="2" type="ORF">RA11412_2790</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006889128.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89089">
        <property type="protein sequence ID" value="BAV89089"/>
        <property type="gene ID" value="RA11412_2790"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2790"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI24217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="104" mass="11017" checksum="8F4BA64DA111C244" modified="2018-10-10" version="1">MAKNRTELVAEVAEKSGKSQATVNAVLDAVFQVFETSVSKGEKITIPGWLAIERTDRAARTGRNPQTGETIQIPAGHGVKLTAGSKLKAAVATKKKAAKTTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QV84</accession>
    <name>A0A2Z5QV84_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08115</name>
        <name evidence="2" type="ORF">RA11412_0009</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887609.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86308">
        <property type="protein sequence ID" value="BAV86308"/>
        <property type="gene ID" value="RA11412_0009"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0009"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="242" mass="24551" checksum="94EEB4B5BDD07B9A" modified="2018-10-10" version="1">MKFTVSTALKRAGAGLTLGAALLAVSGCGYIYTQPTTLHYAASDGVHSTINGNIELRNIMVVSHGKGAEGRVLGTVLNKGNNDATVTFNFPSGAKTVNVPKGQQVRLEQDDHKLVIPQVAPQPGETLSNTRVSVGDASGTLNIPVMDGTLKEYKPYLPGNANASASASHTGAPSASHAATPSGSVSPSAVPETPRASHDATSGRTPEATAETSQAPTLSLAPGATEEPTGAEQSASSASPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVB3</accession>
    <name>A0A2Z5QVB3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclic nucleotide-phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86322">
        <property type="protein sequence ID" value="BAV86322"/>
        <property type="gene ID" value="RA11412_0023"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0023"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="RNA_ligase_T4-Rnl1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA_lig_T4_1" evidence="3">
        <location>
            <begin position="103"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="404" mass="44984" checksum="331DFF7D6E397405" modified="2018-10-10" version="1">MVFSREDSVSGAPEKAVWKREIVEIPSSSLIPDPYASGSRAAGASKSTANGATEPLNDGHRLLEEMRANPNVNVRATEPAGVLACNFTRKAFYKGAWDKTTAKARGLFIHAETGKIVGRGYEKFFNMDEPGHESEAHVRERLAYPAVARAKENGYLAIITVFDGVLTVYSKGGATAYSRHAESILRAALTEEELTRLTEALTRMDSSLTVEVVDPFRDPHIVPYEQVTLYLLDLVANTAQFSVKLARFENLWLSPQAFVQPRPTEDYGSVRISTVEEIPLKDDANFTRLLQNARTSDAEGWVIRDSTGYMVKIKAPGYSATKRARSIPVLVDYLKTAEKLEHSPHAYEDIERFEHNARQAGINLDDYIVQDISARPVWNLPRLAPHLNVLLDGVRTRGRWGQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVF7</accession>
    <name>A0A2Z5QVF7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 17" type="primary">purM</name>
        <name evidence="16" type="ORF">I6I94_07845</name>
        <name evidence="17" type="ORF">NCTC10207_02045</name>
        <name evidence="15" type="ORF">RA11412_0079</name>
    </gene>
    <organism evidence="15 18">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="16 20" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 20">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86378">
        <property type="protein sequence ID" value="BAV86378"/>
        <property type="gene ID" value="RA11412_0079"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0079"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="63"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="179"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV86378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QQT88444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VEI24362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="380" mass="39198" checksum="96C6EB3A772F0E97" modified="2018-10-10" version="1">MTENTAAVTYASAGVDVEAGDRAVELMKDAIRATHSSAVVGGVGGFAGLYDASQLVKYRRPYLATSTDGVGTKVAIAQALDVHDTIGYDLVGMVVDDIVVCGAKPLFMTDYIATGKVVPERIADIVRGIAGACSVAGTALVGGETAEHPGLLAANEYDVAGAATGVVEADELLGPERVREGDVLIGMASSGIHSNGYSLVRKVINVAGWGLERQVDELGRTLGEELLEPTRVYTADCLDLAQAFPVNGPDGQTGTGIRGFSHVTGGGLAANLARVLPQGLEARVDRSSWQIPAIFSLIGSLGNVPLPDLERTLNLGVGMVAIVDPSVAEAAARRLNDRGVPAWVMGDVVAATEPDTDSPDYVQGAKGVNGGAVRLFGQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVR8</accession>
    <name>A0A2Z5QVR8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86497">
        <property type="protein sequence ID" value="BAV86497"/>
        <property type="gene ID" value="RA11412_0198"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0198"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="4808" checksum="1D96D97EFEE4AD8D" modified="2018-10-10" version="1">MWHYTETMSEHSNTPETPAIQPRHVFSSLPKYAAGKPPTPVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVS6</accession>
    <name>A0A2Z5QVS6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07455</name>
        <name evidence="4" type="ORF">NCTC10207_02140</name>
        <name evidence="2" type="ORF">RA11412_0187</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86486">
        <property type="protein sequence ID" value="BAV86486"/>
        <property type="gene ID" value="RA11412_0187"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0187"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI24555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="48" mass="5396" checksum="AF9D8AED34004955" modified="2018-10-10" version="1">MSQNYSDEDFKKLLREISKRFAIAGLVVIALGAAIIGFMYLFYGGIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW49</accession>
    <name>A0A2Z5QW49_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86563">
        <property type="protein sequence ID" value="BAV86563"/>
        <property type="gene ID" value="RA11412_0264"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0264"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="62" mass="6748" checksum="27C43DB2F8D58FCC" modified="2018-10-10" version="1">MQSQAQAAARQSSSQALYTVHNTARGVVLQGNAAQIRELAHRGDVERITPLLPRNGRTPPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWE5</accession>
    <name>A0A2Z5QWE5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86711">
        <property type="protein sequence ID" value="BAV86711"/>
        <property type="gene ID" value="RA11412_0412"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0412"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025831">
        <property type="entry name" value="RecG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038475">
        <property type="entry name" value="RecG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13749">
        <property type="entry name" value="HATPase_c_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c_4" evidence="2">
        <location>
            <begin position="75"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="195"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="258" mass="28389" checksum="3C1FDF2D2E71D485" modified="2018-10-10" version="1">MSGTARNDDRFRGEGPIPAMLEDALAWLVRNLKNRTVTTPDGAGLVDEPEIPLVALREFVANALVHRSYERDASGKFVQIFIKRGRVEIISPGGFWGILPSQVGLVHRPSAVNEALYAICQNIRLSDGRRLIEGEGGGILAAQQALRNAGLREARVLDEGIQVRVIIYRSTDDAQSTRDRRAAQSSQHVDVLQELSATESQVYSALAQKPATVADLVEDTQLTARQVRYALPKLVKRGMAEQRAHSGRRGSVYRLITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWF5</accession>
    <name>A0A2Z5QWF5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86710">
        <property type="protein sequence ID" value="BAV86710"/>
        <property type="gene ID" value="RA11412_0411"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0411"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="134" mass="14947" checksum="865B1DE5CD5F0637" modified="2018-10-10" version="1">MVLGDHQVLIVSVPGLPVQERPCFKGNVAYQRLGDGDYPMDSYALSLMYAQRHKPQNDLRNIPGTSIKDLDEPYTEDFLRQVRLSSARLRHDSDQEILHKRNVLTAAQNDLTLAGLCALGIIRSSFILGQVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWG6</accession>
    <name>A0A2Z5QWG6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Divinyl chlorophyllide a 8-vinyl-reductase, chloroplastic</fullName>
            <ecNumber evidence="4">1.3.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_06295</name>
        <name evidence="7" type="ORF">RA11412_0443</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>NADP(+) + protochlorophyllide a = 3,8-divinyl protochlorophyllide a + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:48884"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58632"/>
            <dbReference type="ChEBI" id="CHEBI:83350"/>
            <dbReference type="EC" id="1.3.1.75"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; chlorophyll biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.75" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86742">
        <property type="protein sequence ID" value="BAV86742"/>
        <property type="gene ID" value="RA11412_0443"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0443"/>
    <dbReference type="UniPathway" id="UPA00668"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033728">
        <property type="term" value="F:divinyl chlorophyllide a 8-vinyl-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015995">
        <property type="term" value="P:chlorophyll biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044201">
        <property type="entry name" value="DVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47378">
        <property type="entry name" value="PTHR47378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="7"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV86742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="287" mass="31189" checksum="904A30674EBDB8BA" modified="2018-10-10" version="1">MNIVVVGASGYAGRHIVEQAHRRGHRVRAVVRDKARAESAGAWGAPSLTNMVDEWAVGDVTDRSWAAGVCDGADAVISALGVTRQKADPWDIDYRANLNILESARAHNVTRFCYVNAIHAELIRSQLTRAKTAFAQALIQSPLAHQVVSPSGYFSDMSSIAQMARRGRVYLLRPQGQVNPIHGADVAAYCLDKVESGQEGSYDIGGPEVLSWREVAQYAFEAVGRPTKITVIPPRLADGAVKGIGLIKPRVADTLSFMLWGLTHDCVGETTGTHRLLDFYRTQVQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWM9</accession>
    <name>A0A2Z5QWM9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3349 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_06085</name>
        <name evidence="1" type="ORF">RA11412_0492</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86791">
        <property type="protein sequence ID" value="BAV86791"/>
        <property type="gene ID" value="RA11412_0492"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0492"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021784">
        <property type="entry name" value="DUF3349"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044918">
        <property type="entry name" value="DUF3349_helical"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11829">
        <property type="entry name" value="DUF3349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="163" mass="18134" checksum="A04685282109630C" modified="2018-10-10" version="1">MPDKNIISRVVDWLSVGYPKDVPVQDRAAVMAILKMRLNDEQLQEVVRRLMQSRAARGEAYVSDQRINEYIRRVVDHAPTPQDIDRVAKILGAHGFLISETHVNDDVDADGHPEYVAYEDPTTGEIRIAELAAAGVTLPNEALENAAEKQETEKITEQASDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWS8</accession>
    <name>A0A2Z5QWS8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86878">
        <property type="protein sequence ID" value="BAV86878"/>
        <property type="gene ID" value="RA11412_0579"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0579"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="33"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="374" mass="42185" checksum="8C411A11BBCACE9A" modified="2018-10-10" version="1">MPRREYGEPLNGHCRAPPTTTSESKTAPRQRLVYLDLINTVAIVWVVLLHVRFIIPDNPSSSAWWVENILSGFGGAAVPLFFMATGINLLEFTRRESVGTFYRKRFTKILIPMILWAQIYLFAHIWTDSTPFPDAHQILRTLLAPSSEAATFWYLEALVGVYLALPIFSYAIHGAWQNQAPASRTKFLWLMAVLGLLLPVLTHAAHLINPRVMPEFIAPLTGYLGFCLLGYALAHTELSRRWRLVIYALGAAGLAGYILGGAYLIAEHPALKPLAREYLSIPLILWASAVLVFCKYSRINRASPTTQGILKKLAALTFGIYLVHLLLIQILHTLQFPLTDVRWEIPYTLLVWALSVVTVWALRLIPPVRRWILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWU9</accession>
    <name>A0A2Z5QWU9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_05620</name>
        <name evidence="3" type="ORF">RA11412_0616</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86915">
        <property type="protein sequence ID" value="BAV86915"/>
        <property type="gene ID" value="RA11412_0616"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0616"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="21"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="195"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="416" mass="45572" checksum="D69344DCEEB6905B" modified="2018-10-10" version="1">MSYLKRSLDLELDELFPFVPAIAIDGPKAVGKTVTALRRADQVYYLDNAAQREFLQADFLLASLPSGTVLLDEWQQLPEIWNSVRRNVDEGAPSKRFLLTGSATPVDQSGTHSGAGRILSARMRPLTFYERYRPSNPVSLRSLLKGEQPVIEGSTDVSLNDYVKAIVEGGFPATLGQPDRVCRAYLDAYVQRIIDRDIPELGRSVRYPETLKRWMQAYAAASSSTASYSRILDATTAGDGVQPAKTTTNLYRNFLTKLWILDPVPGWAPASNEFTRLTVSPKHQLADPALAARLLQLSASTLTSSQGAHMLGPLFESLVTLSVRVAAQAAEATVSHLRTKNGDHEVDLIVQGPEGEVLGIEVKLAPVITDTDVRHLLWLRDKTPDSVTNLVVITTGAQVYRRADGVLVLPLSLLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWW0</accession>
    <name>A0A2Z5QWW0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05785</name>
        <name evidence="2" type="ORF">RA11412_0571</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86870">
        <property type="protein sequence ID" value="BAV86870"/>
        <property type="gene ID" value="RA11412_0571"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0571"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="291" mass="32739" checksum="106562EC955FA3F3" modified="2018-10-10" version="1">MTVDILFPYYGDVELMKQAVRSVIGQSNPDWRLIVVDDGYPDESIPGWFASLNDERITYMRNEKNLGANGNYRKCLTFVENELVTVMGADDVMLPNYVQWLVDAAAAHPQASVFQPGVVVIDEHNAASNTLVEKTKAFYRPNHSTLLQGEDLALSLLRGNWFYFPSLGWRADAITQTGFRQGLNVVQDMALVLDIAMNGGALFYDKTLAFMYRRHGGSDSSWRALEGTRFDEERTYFTTIAAELEALRWKKAAKAARIRFSSRAHALTLLPKAALAKKWRGVKNLAVHVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWX4</accession>
    <name>A0A2Z5QWX4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
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            <fullName evidence="3">Two-component system response regulator</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86844">
        <property type="protein sequence ID" value="BAV86844"/>
        <property type="gene ID" value="RA11412_0545"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0545"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="155" mass="17081" checksum="FE2F0F918C9E6DA8" modified="2018-10-10" version="1">MSSKATEIAKNLPTLEHPDGSPIRALVADDEEMLKELVSMGLKMIGWDVRSATDGPTALAIARDWRPDVLVLDIMMPGFDGLELLERIRKFYPEVPCLFLTAKDSVDNRIEGLAAGADDYVTKPFSMEEVMIRLHRLVQRSGVAAVDDAELVVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXB5</accession>
    <name>A0A2Z5QXB5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lanthionine synthetase C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87095">
        <property type="protein sequence ID" value="BAV87095"/>
        <property type="gene ID" value="RA11412_0796"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0796"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025410">
        <property type="entry name" value="Lant_dehyd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13575">
        <property type="entry name" value="DUF4135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4135" evidence="1">
        <location>
            <begin position="96"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="520" mass="58571" checksum="4CB97344F7D388C3" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXC2</accession>
    <name>A0A2Z5QXC2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87088">
        <property type="protein sequence ID" value="BAV87088"/>
        <property type="gene ID" value="RA11412_0789"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0789"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="492" mass="54947" checksum="4C52189B68D95EE9" modified="2018-10-10" version="1">MAEQKKRIAVNAFDMTCVGHQSFDLWRHPRSRATEYNTIKYWTDLAQILEKGFFDGVFLADVVGIYDIYKNSAAPAIEGGAQVPVNDPFMQISAMAAVTEHLGFGVTSAVTYEQPYTLARKYASLDHLTNGRVGFNVVTSYLPSAAECQGLETQIEHDTRYELAEEFLDVCYKLWEGSWEDGAVVKDREKGIYADPAKVHPIQHKGKYFSVPGAGLTEPSPQRTPVIFQAGASSRGQKFSGKHAEVVFIGALRPDLTRIITDRIRDRAEENGRGRDEIKVFAMLSIIVDETEEKAKAKYEEYRKYVNLESSQAIIGGWSGVDLSQFDEDEVLNYVKTESIQSFLTPSPCRPRISSGRVRILPSTALLAVWARLLWATRSRWLTNSNAGLMKADWTVLTWHTTFRPAPSRTSSSSWFLSCKSVDATAPPTKVRPCAKACSVRDRLRLQTPTRPRSTVAPTWVSPPRQIPRHALSQTKPAAPVRMVAKCPLLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXF2</accession>
    <name>A0A2Z5QXF2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heme ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Heme ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_04655</name>
        <name evidence="5" type="ORF">RA11412_0836</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87135">
        <property type="protein sequence ID" value="BAV87135"/>
        <property type="gene ID" value="RA11412_0836"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0836"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="253" mass="27670" checksum="396CA42EFDD70375" modified="2018-10-10" version="1">MLRVENISYSVGSRRILEDISFEVHANEVVSLIGPNGAGKSTLLSVIAGDVKQDSGVVQLDGALTSSYSPRDLARRRAVLLQKTQVAFSYTVREVVAMGRTPWRGTIRIDEDEAVIEQMMIRTEVAQFAERDITTLSGGESGRAHLARVFAQQTPLLLLDEPTAALDIRHQEQTLKSARDLASEGAGVLTVLHDLDVAAAYSDRIVLLQQGRVVCVGSPEQVCTAQRLSEVYGYPIEVLKHPVTGRLLILPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXL6</accession>
    <name>A0A2Z5QXL6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_04750</name>
        <name evidence="1" type="ORF">RA11412_0812</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87111">
        <property type="protein sequence ID" value="BAV87111"/>
        <property type="gene ID" value="RA11412_0812"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0812"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="160" mass="16835" checksum="15860401B5064408" modified="2018-10-10" version="1">MSFDYMPSETFQRADLDLLLSVRIDVARVPGGASQRQILDAVRSFLCSLTRDDSADGLTLDPDLGFARPYYAGGFTVGVVPASGRGRVALAGIHEGAQTVDSGRFSVPSKGEAGWRIVTSVVVSSAGEDVLDSLEAGIEYLTDALGDLRVGLSLTELPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXM2</accession>
    <name>A0A2Z5QXM2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-binding domain protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_04985</name>
        <name evidence="2" type="ORF">RA11412_0761</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013398362.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87060">
        <property type="protein sequence ID" value="BAV87060"/>
        <property type="gene ID" value="RA11412_0761"/>
    </dbReference>
    <dbReference type="GeneID" id="29742739"/>
    <dbReference type="KEGG" id="raj:RA11412_0761"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="167" mass="18195" checksum="B38394C9EBEF15A7" modified="2018-10-10" version="1">MTEKRTWVGPSAPERLNILRNTRTIAIVGMSDKISRASNFVATYLLSSSPYTVYFVNPILAAKGKTVLGQPVYASLQDLPEVPDLVEIFRRNEDLPGVVQEAVDLGAKTVWMQLGSWNEEAAAIGEAAGLNVVMDRCVKIEHARFHGGLHLAGFNTGVISSKRQVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXP7</accession>
    <name>A0A2Z5QXP7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NCTC10207_00379</name>
        <name evidence="2" type="ORF">RA11412_0913</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87212">
        <property type="protein sequence ID" value="BAV87212"/>
        <property type="gene ID" value="RA11412_0913"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0913"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025338">
        <property type="entry name" value="DUF4244"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14029">
        <property type="entry name" value="DUF4244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI22304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <sequence length="119" mass="12335" checksum="9B75EB2B3A0C305B" modified="2018-10-10" version="1">MTAVYPSLTALANQEFLATHDTGCTTEMCTPLCRQASQFAQLPTGMIDTDRITAAYTATGANTAAHAPVGDPEEGASTAEYGIVMLAAVGFAGLLVAILKSDEVREMLLGVIRNALSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXQ4</accession>
    <name>A0A2Z5QXQ4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dipeptide transport system permease protein DppB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_0824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87123">
        <property type="protein sequence ID" value="BAV87123"/>
        <property type="gene ID" value="RA11412_0824"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0824"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="96" mass="11002" checksum="B57D5DAE377FF997" modified="2018-10-10" version="1">MTKFDWGRSPNGAYVNEEFGQRVWVSFRLMIAATILTIVIGVALGVFTAARQYKLSDRVITSYSYLVYIIPAPVAYFWCRPLRFRLTSPQGRPFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXR1</accession>
    <name>A0A2Z5QXR1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_04250</name>
        <name evidence="4" type="ORF">NCTC10207_00410</name>
        <name evidence="2" type="ORF">RA11412_0946</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888276.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87245">
        <property type="protein sequence ID" value="BAV87245"/>
        <property type="gene ID" value="RA11412_0946"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0946"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI22335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="169" mass="17908" checksum="44F0788FC8222452" modified="2018-10-10" version="1">MSNSATQVRTAQIGGGRISDGPANLRASFSASKVSAGHRTTSPKILSVLYTARVIGLALPYVFTFAAVLGGDLYSQWAHVMFHPIGQFMLAYALAHVTANICFNFRRGGALVRTVNGVGAVLCVAVSPLWVNLIMSGANSPDALWALIGVPLEFAACIGYYVYTARRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXT0</accession>
    <name>A0A2Z5QXT0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87267">
        <property type="protein sequence ID" value="BAV87267"/>
        <property type="gene ID" value="RA11412_0968"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0968"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="549" mass="57088" checksum="FD229F2AC7E4A795" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXT7</accession>
    <name>A0A2Z5QXT7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lactate-responsive regulator LldR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_0969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87268">
        <property type="protein sequence ID" value="BAV87268"/>
        <property type="gene ID" value="RA11412_0969"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0969"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="398" mass="43800" checksum="57F2521B5752ED38" modified="2018-10-10" version="1">MAIHRKILRWLENELTEGNLQLGQDLPDDQRIARAIGLGRSRTREGLKTLEDMDLVRLYSGKGKEIIAHLNEEPAMAAAEPLRLHMAVSRYPKRDLVQTHMLLEGWSVANIDPGVADFGEVDELLEEMQEGGHPIREFLDLYLDFHLELSRLANNELIAGLLIAIRQPTFDALLSLAGRVPLWSSTMERLNAENRAVLEAVKDADSATARNLMMNQMRGLFDEAGVDLDESAVALTGMPGTSDLRMFEPVDIEDDFGPFPEEGPSFGWGFGAERFGNAPGGAPVPSSGSQQARRDTSQQSQQHYDGQQGQQEQQSNLPLSFGTASGRAAAAFTRPSEGAPAAQTGNNGASQPPRTHPGNRMRLIMLPLHRRLTSQCSTALCRVVRSRAQLSLHPPRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXU4</accession>
    <name>A0A2Z5QXU4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(Fe-S)-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Predicted L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_04550</name>
        <name evidence="2" type="ORF">RA11412_0864</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888621.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87163">
        <property type="protein sequence ID" value="BAV87163"/>
        <property type="gene ID" value="RA11412_0864"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0864"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="140"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="263" mass="28391" checksum="725130401A085BC3" modified="2018-10-10" version="1">MRIALFSTCIVDGMYPRVARATVEILERLGHEVVYPPGQTCCSQMHVNSGYFDDAYPIVKNHVDAFSAWDWDVAVAPSGSCVASLGHQQPMIARRKGDEALAVKAEQIAARTFELSQLLIDVLGITNAAEQLGSYFPEHVTYHSSCHGMRLLHLGTRQQDLVRTVEGIKYTEIEDLDQCCGFGGTFSFKNADVSGAMVEDKATNVEKTGASVCTGGDCSCLMNIGGALSRKGSPVKTIHFAEILASTKANPLKIDGNVELAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXW3</accession>
    <name>A0A2Z5QXW3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable secreted peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_0884</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87183">
        <property type="protein sequence ID" value="BAV87183"/>
        <property type="gene ID" value="RA11412_0884"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0884"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045051">
        <property type="entry name" value="SBT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10795">
        <property type="entry name" value="PTHR10795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PA" evidence="5">
        <location>
            <begin position="43"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="4">
        <location>
            <begin position="142"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="287" mass="29629" checksum="89536E1A05817C73" modified="2018-10-10" version="1">MANSESALTRSDRFEVKGPSAVAGAYAGSYSTLYTFASNNARVSGTVTAAPESNKTGCAPFTGTNFGGRWVMLHWEASGSDPSCDSARRFANVAAANGKGVLMVAPENDDRPIAGSTTIPGVLISRATAQTLYPAVKAGTLEIELGAAWRNTALTAKGPDMLAASSARGVHGSDGFVKPDVAAPGTNIYSAGAGSGNQPFRLSGTSMATPHVAGIAAQILSKEPFLSQQQVKARIMNTASQEVRTISGERLGVDRVGAGRVDAQAAVNERTTAYNTQNPSRSLYLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY95</accession>
    <name>A0A2Z5QY95_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87323">
        <property type="protein sequence ID" value="BAV87323"/>
        <property type="gene ID" value="RA11412_1024"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1024"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="2">
        <location>
            <begin position="269"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="310" mass="32946" checksum="645091F7B2EAA4E6" modified="2018-10-10" version="1">MVVTGVAHANAVTQQIPELRAADLVLEPSPRDSAAAIGLACAILHRREPDAIIGSFAADHVISPVDEFQRVVIEAVETAATGKIVTIGITPTHPSSAFGYIHARESLGIEQAPHALAVDSFVEKPDAATAQKYLDSGEYAWNAGMFVAPAELMLKHLAANEPELHAGIMQIANAWDSPEREDIMERVWGTLPKTAIDYAVAEPAAAAGDVAMVPGSFSWDDVGDFDAVARLNQEKTGEDLTILGDNQNVLNQGCSGIVVSTTDRKISVIGLDDIVVVDTDDALLVAPRSQAQKVKEAVSELKERGLTELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY96</accession>
    <name>A0A2Z5QY96_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03970</name>
        <name evidence="2" type="ORF">RA11412_1017</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87316">
        <property type="protein sequence ID" value="BAV87316"/>
        <property type="gene ID" value="RA11412_1017"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1017"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="155" mass="16441" checksum="1009D9273435B6DA" modified="2018-10-10" version="1">MNTMLTHDAHPDAASQASERKAMIGAGAGMLILVVLLGAAIAAADSVLGWVLAGLILGWLGLACYLVVGVLSAVRANRASYKALAHARAEEQDGMLADKLSHSFQIVLVQSREISKYLNEDGEQSRAMIERALDTINTTASNGMGMVNDEMRGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYB0</accession>
    <name>A0A2Z5QYB0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrolipoamide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87457">
        <property type="protein sequence ID" value="BAV87457"/>
        <property type="gene ID" value="RA11412_1158"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1158"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_dim" evidence="1">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="104" mass="11127" checksum="582180FEE2A9A3D0" modified="2018-10-10" version="1">MGVSEKDIEEGLYRGDTVMLSLTTNPRAKMMAVSDGFVKVFARKHSGTVIGGVVVGPRASELIFPISLAVEKKLTVDDLAETFTVYPSLSGSVSEAARKLHTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYC3</accession>
    <name>A0A2Z5QYC3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">dnaK</name>
        <name evidence="11" type="ORF">I6I94_04080</name>
        <name evidence="10" type="ORF">RA11412_0992</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888157.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87291">
        <property type="protein sequence ID" value="BAV87291"/>
        <property type="gene ID" value="RA11412_0992"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0992"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="584"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="615" mass="65801" checksum="8CE15B595C145A92" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYJ9</accession>
    <name>A0A2Z5QYJ9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">dTDP-4-dehydrorhamnose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_1127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87426">
        <property type="protein sequence ID" value="BAV87426"/>
        <property type="gene ID" value="RA11412_1127"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1127"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="6">
        <location>
            <begin position="188"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="4">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="271" mass="29998" checksum="90E1C33BE7B1375C" modified="2018-10-10" version="1">MTKELNVRATDIPGLLVIDLPVHGDNRGWFKENWQREKMRAAGLPDFDPVQNNISFNTSVGTTRGIHAEPWDKYVSVASGRIFGAWVDLRAGESFGRVVTVELGPDTAIFVPRGVGNAFQTLEENTAYTYLVNDHWSADALTAYSFLNLADESAAIDWPIDLAQAELSEKDRKHPRLHEITPLTPDPLLIVGASGQLGRELVRQLTAKNIPFEAVDRDRLDLGTPEKWRNAFRWRSYRAVINAAAYTAVDNAETPRGAAKPGPPTPTESPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYK3</accession>
    <name>A0A2Z5QYK3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87532">
        <property type="protein sequence ID" value="BAV87532"/>
        <property type="gene ID" value="RA11412_1233"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1233"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="82" mass="9175" checksum="EBE49C9DED6DE2BD" modified="2018-10-10" version="1">MYKADAGLTSLDTAQIQGLWVHPDYRGLGLAASLTAAACALLRRRYRHLSLYVNDYNARARALYARLGWEPVGEYATVIFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYL5</accession>
    <name>A0A2Z5QYL5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 14" type="primary">eno</name>
        <name evidence="14" type="ORF">I6I94_03905</name>
        <name evidence="13" type="ORF">RA11412_1035</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87334">
        <property type="protein sequence ID" value="BAV87334"/>
        <property type="gene ID" value="RA11412_1035"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1035"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="139"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="362"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV87334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT89758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="427" mass="45507" checksum="939DF829C29CEE43" modified="2018-10-10" version="1">MAVITAVHARQILDSRGNPTVEVEVLLEDGAFARAAVPSGASTGEWEAVERRDGDKSVYLGKGVLGAVKSVIEEISEEIIGIDAADQRTVDQAMIALDATNNKGKLGANAILGVSLAVAKAAAESADLPLYKYLGGPNAHVLPVPMMNILNGGSHADSNVDIQEFMIAPIGFENYSDALRAGVEVYHSLKSVLHDRGLSTGLGDEGGFAPNLESNAAALDLIIEAIEKAGYKPGEQVALALDVASSEFYNDGAYEFEGKKKSAEEMSAYYADLVAKYPLVSIEDPLDENDWAGYKTLTEQIGEKVQIVGDDLFVTNPERLEKGINEGAANALLVKVNQIGSLTETLDAMELAQRSEYRCMVSHRSGETEDVTIADLAVATNAGQIKTGAPARSERVAKYNQLLRIEEELGDAAVYAGKSAFPRFKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYT4</accession>
    <name>A0A2Z5QYT4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87470">
        <property type="protein sequence ID" value="BAV87470"/>
        <property type="gene ID" value="RA11412_1171"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1171"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="85" mass="8791" checksum="AE47C87259965A15" modified="2018-10-10" version="1">MAAYNPLSYFSFGKKKEEGASLSNPNTEPETAAAGSTEQGLPGGPEAAGTAAPVVHQQAEDAAQQSPAPLLRVVKGNPQMRKSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYT8</accession>
    <name>A0A2Z5QYT8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription-repair coupling factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87451">
        <property type="protein sequence ID" value="BAV87451"/>
        <property type="gene ID" value="RA11412_1152"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1152"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="704"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="851" mass="92451" checksum="2463555FE0379F1A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYY3</accession>
    <name>A0A2Z5QYY3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87444">
        <property type="protein sequence ID" value="BAV87444"/>
        <property type="gene ID" value="RA11412_1145"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1145"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="139" mass="15335" checksum="79E3D6EF97516BFB" modified="2018-10-10" version="1">MVDSIRVPCIHLAALVGFIRYPQHFSLTGAADGFPSGWSLWWLPMAFTVLTAGHFMSQILAEQLRNNRKTAAPSTGGTMRSFINLHMDAGTLCWIFIVWGFGPLFVVIYALLFAANAATVLLSMRRKYVTLSTPTTPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ09</accession>
    <name>A0A2Z5QZ09_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Glutamine synthetase</fullName>
            <ecNumber evidence="4">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glnA</name>
        <name evidence="7" type="ORF">I6I94_02365</name>
        <name evidence="8" type="ORF">NCTC10207_00815</name>
        <name evidence="6" type="ORF">RA11412_1426</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888867.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87725">
        <property type="protein sequence ID" value="BAV87725"/>
        <property type="gene ID" value="RA11412_1426"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1426"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="5">
        <location>
            <begin position="104"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI22730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="446" mass="50270" checksum="8F242EECEC8DD546" modified="2018-10-10" version="1">MDRQQEFVMRTIEERDIRFIRLWFTDVVGTLKSVALAPAEVESAFEEGLGFDGSSIEGLSRVYESDMLLQPDPSTFQILPWRGAESHTSRMFCDILTPDGEASASDTRGVLKRTLNRAAEMGFTCYTSPEIEFYLLKSTELGADGFPVPVDYESYFDHTPGGIVQDFRRNAVTMLEEVGISVEFSHHETGPGQNEIDLRHADALQTADNVMTFRTVIKEVAFTRNMYATFMPKPFTKYAGSGMHTHFSLFEGDTNAFFEAGAEYRLSKTGRHFIAGVLKHAPEFTAVTNQFINSYKRLWGGGEAPSYVSWGHNNRSALVRVPLYKPNKMQSARIEYRGLDSASNPYLAYAVILSAGLKGIENEYELMPAVTEDLAAMTTAERRAMGYHPLPASLREAINLTEDSEFMAEVLGEQVFEHFLRNKRADWEDYRAQVTPYELKHNLGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ31</accession>
    <name>A0A2Z5QZ31_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polynucleotide phosphorylase</fullName>
            <shortName evidence="7">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">pnp</name>
        <name evidence="10" type="ORF">I6I94_03075</name>
        <name evidence="11" type="ORF">NCTC10207_00661</name>
        <name evidence="9" type="ORF">RA11412_1251</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87550">
        <property type="protein sequence ID" value="BAV87550"/>
        <property type="gene ID" value="RA11412_1251"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1251"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014069">
        <property type="entry name" value="GPSI/PNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02696">
        <property type="entry name" value="pppGpp_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="660"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VEI22580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="737" mass="78996" checksum="3E5C41AFFFB3AF92" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ39</accession>
    <name>A0A2Z5QZ39_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87571">
        <property type="protein sequence ID" value="BAV87571"/>
        <property type="gene ID" value="RA11412_1272"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1272"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="60" mass="6622" checksum="A6CDB575B86EBB3E" modified="2018-10-10" version="1">MHEAFFFFPKRPLENRALTAVESNEVAAPRSWPAIAVFAQNGVEISAGERLKMSLVCKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ40</accession>
    <name>A0A2Z5QZ40_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_1334</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87633">
        <property type="protein sequence ID" value="BAV87633"/>
        <property type="gene ID" value="RA11412_1334"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1334"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="13"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="174"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="365" mass="39402" checksum="23432E15EA9C5B45" modified="2018-10-10" version="1">MTGRSSRSHTRPTPLQAGVEQYLTYLRVEKGSSDNTILSYTRDLRRYSAYLATRGIIAPERIRTADVRAFMRELANPTVPLPEPQTAQDRKAAEQDAHDALAATIYAGDKASAAPPPHNSLSAPAGQILPVPLGPNSIARTMAAVRGAHAFWHSSRTTDTDPAAAVKPPKNVKRLPKAVTVEQMQRLLAVPSLETPTGLRDRAILEFLYATGARVSEMLAADIDDVHLGESTTDEHGETVTLPGYVRLFGKGGKERLVPVGSYAQRALQNYLVRARPVFAAHGKGTAALFLNGRGSRLGRQGAWLILKSAAEQAGLTQDFSPHSMRHSFATHLLQGGADIRVVQELLGHASIATTQVYTRVSPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ58</accession>
    <name>A0A2Z5QZ58_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87514">
        <property type="protein sequence ID" value="BAV87514"/>
        <property type="gene ID" value="RA11412_1215"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1215"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="490" mass="52812" checksum="48FA7150CDC23725" modified="2018-10-10" version="1">MDEASIKSYYTVSSKASTSAGKEELGRTLTFEASNLEDMNSKLQKIFGNKNTELKHEQEVNDTSGKLMVKNHVSGQVDCSIVCSPEGNGALFKLSGSNGVYTEQGGSSNSGSSKNIVQNVDLSSTQEIKVQDARTSVSLGMDGSVEARFEYSVKNSDAALASEALKKKFSPGDDIGTLEEGNDGDNTVYSTVIKGKDSADFNNRLEGYLPGSTFTITHPGGYNPFGTSYTVEPAFNLKSRVGDGYSGSYSFSFNAPFMSTVDQKKFETQNSLPEGAKTEAEGRNLTVSNEHGTFTLRIPAAGLTMSDMVIDGVIVLLVLLIVMILLLFRRRISSSLRNSREQRAALAAAQQAQGYGHGGNPEAYFMSRSGGGHQTQGYNPAQPAYSEEGTYQQDQYPPQKSGYGEPPTVPINDMGSNGAWDDETHPMPQYAPQEGIGEPTAPMSYQQVTYEEPTQAISGNGAVQHEPPTRPVSEPPRSGSSSQREQDYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ80</accession>
    <name>A0A2Z5QZ80_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clustered with transcription termination protein NusA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87534">
        <property type="protein sequence ID" value="BAV87534"/>
        <property type="gene ID" value="RA11412_1235"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1235"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="112" mass="11751" checksum="F07A8E974EA9B0BB" modified="2018-10-10" version="1">MAYKPKRSGGKKGGASNARARRAASRAASGVSRAPAEKAPQAPVGTRPLHADEVRAAIEPTLAEFSLVVESIKITGPAQNCTVEITVDYTEDRADSLSLDTIAEISGYSLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ89</accession>
    <name>A0A2Z5QZ89_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">prfA</name>
        <name evidence="8" type="ORF">I6I94_02235</name>
        <name evidence="7" type="ORF">RA11412_1458</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87757">
        <property type="protein sequence ID" value="BAV87757"/>
        <property type="gene ID" value="RA11412_1458"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1458"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="360" mass="39705" checksum="2A5ABE0ECB7C3D39" modified="2018-10-10" version="1">MFESIQVLLDEHADLQAQLADPAVQANQGKARRVGRRYAELTGIVSAYNKYKGFSDDLEAAREMAAEDPEFAAEVPVLEAELEAAGEKLRRLLIPRDPDDGRNVILEVKAGAGGDEAALFAGDLLRMYVRYAEHKGWKTEIISSTSTDVGGYKDAQIAIKGTSNEPAEGVWAHLKYEGGVHRVQRVPATESQGRIHTSAAGVLVFPEVDEPEEIEISQNDLKIDVYRSSGPGGQSVNTTDSAVRITHLPTGIVVAMQNEKSQLQNREAAMRVLRARLLAHQQEQIEAENAAHRASQVRTMDRSERIRTYNFPENRIADHRTGYKAYNLDAVLGGDLEPVVQSAIEMDEAHRLSQVGQEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ96</accession>
    <name>A0A2Z5QZ96_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87815">
        <property type="protein sequence ID" value="BAV87815"/>
        <property type="gene ID" value="RA11412_1516"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1516"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="102" mass="11104" checksum="BAC54189AB98ACD6" modified="2018-10-10" version="1">MHLPVVLVGISLFIIVTNHSFSVHLSGYSVGAAVFAFACTSLMTSVMTRFIGIRWLLGMYAVVNIPALVYLSHLSGGGGASAPPSMRSCVWRWGLRYRRGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZB9</accession>
    <name>A0A2Z5QZB9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">murC</name>
        <name evidence="15" type="ORF">RA11412_1404</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87703">
        <property type="protein sequence ID" value="BAV87703"/>
        <property type="gene ID" value="RA11412_1404"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1404"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="12">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="14">
        <location>
            <begin position="129"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="13">
        <location>
            <begin position="342"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="131"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV87703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="463" mass="48614" checksum="058DF71FC7D15438" modified="2018-10-10" version="1">MNLDLVLPAPLNPPFPERARVADLGRVHFVGVGGAGMSAIALLMAQLGVPVSGSDRAESANLQSLRQAGVRVSVPQDAVNIHDVDTVVISTAIHEDNPELVKARELGLPVLHRSEALAAVMGDSQVVAVAGTHGKSTTSSMISVMFDGLNAKPSFAVGTVIAGFGTNARLGATGPGSWFVAEADESDGSFVRYRPKVAVVTNIEPDHIDFYGTAERVYEAFNRFVASMVPDGVLITCADDAGAVSLAQRSRAAGLQVLTYGESEDADVRLSQITSHGSQSSSVLSWSFDLAGQHYSGEQELNLQVPGVHNQLNAAASFATALVAGARPADAASALGGFVGADRRFTLRGEIAGIKVFDDYAHHPTEVLCALQTGRTVAGGHNLYVVFQPHLFSRTKEFAQEFAQALSLADRAYVLDIYPAREEPIEGVTSELITGAGFSEVHYASDATVAIDDIVTCASAGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZD5</accession>
    <name>A0A2Z5QZD5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_02375</name>
        <name evidence="7" type="ORF">RA11412_1424</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87723">
        <property type="protein sequence ID" value="BAV87723"/>
        <property type="gene ID" value="RA11412_1424"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1424"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="6">
        <location>
            <begin position="68"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="458" mass="50245" checksum="FDB66C314A4784CE" modified="2018-10-10" version="1">MNTFPTHTCTERIRRTFRRTHRTFLAMALAAVLGVGHTVVTSVVLPSASSAVVGTRTFDSRLDPAHPVVDKTGVLSTEQIQQMSVPLADVSARRGVSLQVVVIDRAAPEWADNWGHKFLRQNGAGPDDKTALLLIELDPQGTGDKNATPEASFHSLNMHYLGATEGSEIRNKIINPLLEKRDFTGIAQAMAKAFDNSTGYPDKYNIQPAPQTATPTPSPTPSPTAAGQSVMKTELNPEDPVFSLTSYSLTDPKLWPELISFNKNNDAQLYVVLLTKPENPSDLQEWGKEFLRVNNAPARTAVLVCQGDGTRDDPRKCLVTTNDSGFISDNSLHKINNDYVKEKSNYNDFGGIIRAALEGIRKESLDAKTKAAPKESNGFLDTVLVFLIIGLFIAFICAAIIGFGNFIIKVYRGLSRIFAGTPKSNTLEDSNKPDQSRTNIPNIDKLAIENWEKYSLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZF7</accession>
    <name>A0A2Z5QZF7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_01945</name>
        <name evidence="2" type="ORF">RA11412_1528</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023134655.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87827">
        <property type="protein sequence ID" value="BAV87827"/>
        <property type="gene ID" value="RA11412_1528"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1528"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="170" mass="18695" checksum="5DC3A7D8B3E08307" modified="2018-10-10" version="1">MTDVKNTADTDVAQANQQQGTQQLTGEQVIRVLHPAFDNQIINYGAYNLVYATGSATYRNPDIAALQEDHQECFLVGYQDSPDEVIIAPIHMPEVTPAGAATTIDNTNALHAHLTNDNLTIMLESINGSRFRLTLLDKPEITTHAGTGTIDQTLDVQDFRTFVTTIWPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZT8</accession>
    <name>A0A2Z5QZT8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87876">
        <property type="protein sequence ID" value="BAV87876"/>
        <property type="gene ID" value="RA11412_1577"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1577"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="49" mass="5386" checksum="42217150B4D38EFC" modified="2018-10-10" version="1">MVFPAYVGMSPPSAKKRLHQTGVPRIRGDEPMDKAYNDGGLECSPHTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZU5</accession>
    <name>A0A2Z5QZU5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87811">
        <property type="protein sequence ID" value="BAV87811"/>
        <property type="gene ID" value="RA11412_1512"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1512"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="65" mass="7724" checksum="F194036F3C1DED23" modified="2018-10-10" version="1">MRAMRERKILKQTSAELMDWHFRPKLSEFPHGPIQNELPEEFYFKSNRLIVSHRETSAKGEGEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZV0</accession>
    <name>A0A2Z5QZV0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87893">
        <property type="protein sequence ID" value="BAV87893"/>
        <property type="gene ID" value="RA11412_1594"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1594"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="46" mass="5015" checksum="E16A271BE4C9C42F" modified="2018-10-10" version="1">MVFGVALAGVSCPFRHRTAAVLRITHQGRAPLFYGVPLRFFTQPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZV3</accession>
    <name>A0A2Z5QZV3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Possible excisionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_01265</name>
        <name evidence="2" type="ORF">RA11412_1689</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87988">
        <property type="protein sequence ID" value="BAV87988"/>
        <property type="gene ID" value="RA11412_1689"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1689"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="72"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="145" mass="16284" checksum="1B3F1DC374E05953" modified="2018-10-10" version="1">MSVQHTQVFAAEPLIEQAPDLTEEFVQSLTVQGTLPNGQTVQAPEKVTDFIRAQLTALLNHQNIAVNFTPDVLTTSEAAELLGLSRPTLAKWADEGRLPSHKAGTHRRFKREDVLVFREQQRAQKRAALHDLLKFQIAHPEIDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZX4</accession>
    <name>A0A2Z5QZX4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster regulator SufR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88055">
        <property type="protein sequence ID" value="BAV88055"/>
        <property type="gene ID" value="RA11412_1756"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1756"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="207" mass="22162" checksum="6EC63E3BA8BB3142" modified="2018-10-10" version="1">MIEVAPLKQYGAGAGRPARRYVIAPQGHERLGNDYLLIARNALEMLRDTVGESALEAFASARAAEMEARYRPVVEAAGDDVAARAKALAEAMSRDGFVATAQFTEPPAGRKVPEHFLASIQLCQGHCPVRDLAEDFQVFCEQETWIISDLLGVDVRRLSTMAGGAHVCTTHVPLNRVPETAEPETSAAPHPEATESTPDAATAASDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R030</accession>
    <name>A0A2Z5R030_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0246 protein YaaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87901">
        <property type="protein sequence ID" value="BAV87901"/>
        <property type="gene ID" value="RA11412_1602"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1602"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="60" mass="6378" checksum="7DC1A97F8BB318F5" modified="2018-10-10" version="1">MLILLPPSEGKTAAEATNAPVQFADLSFPELTGERETVLEQLAAVSAQETALEQLKVGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R079</accession>
    <name>A0A2Z5R079_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87946">
        <property type="protein sequence ID" value="BAV87946"/>
        <property type="gene ID" value="RA11412_1647"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1647"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="71" mass="7738" checksum="F40C1F8B7A79545E" modified="2018-10-10" version="1">MTKRVFADDNTNLMERDGLGRLLSHTDALGQHTDTTTRPNRVKVYDAGKIIGASDGVDTPYIRAECSQGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0E9</accession>
    <name>A0A2Z5R0E9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Holliday junction DNA helicase RuvB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88212">
        <property type="protein sequence ID" value="BAV88212"/>
        <property type="gene ID" value="RA11412_1913"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1913"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="60" mass="6411" checksum="2B9E1DB853838244" modified="2018-10-10" version="1">MTDNPYEPTPSGGYAPGQVPGQQRLVAMEEEPEEKMIEAALRPKSLGDFVGQKGCGSSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0H3</accession>
    <name>A0A2Z5R0H3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murT</name>
        <name evidence="5" type="ORF">NCTC10207_01217</name>
        <name evidence="4" type="ORF">RA11412_1919</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:59488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with GatD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88218">
        <property type="protein sequence ID" value="BAV88218"/>
        <property type="gene ID" value="RA11412_1919"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1919"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02214">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043703">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="55"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="MurT_C" evidence="3">
        <location>
            <begin position="305"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI23120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <sequence length="427" mass="46268" checksum="7B3D2FFB167D3C22" modified="2018-10-10" version="1">MCMSKPLIRLLGQGVRYASKLRGGGSAFPGLVMEKLHPEFVAEELAKLPYGVVVVSGTNGKTTTTKMTVQLLESQGLKVFTNRTGSNFVRGVAAALLGAMSLTGKLDADIAVLELDEAHAVHFVKAVKPDYALLLNVLRDQLDRFGEIDTTRRMLSTVAAATTKTVVLNREDPRIRSLAQAVQPGTNISYFGLNDELRSYFPSDDELRSGVGARSADLPDSDVTLTAFSGSSATFNLAGQSITGQINLYGIYNIFNAAAAMALTRAVMGEKLNQDALVNELAKITPAFGRGETLNVNGRPLQLLLVKNPSGFRLSLASANSHDYATMITINDQYADGRDVSWLWDVDFHDLAATGVKMVSGVRAWDMALRLEHDGVPVEDVQEDLDDALRSFIANSGQAPMRIFCTYTSMLALREELGKITNVERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0I0</accession>
    <name>A0A2Z5R0I0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87976">
        <property type="protein sequence ID" value="BAV87976"/>
        <property type="gene ID" value="RA11412_1677"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1677"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="397" mass="44440" checksum="779415782098CF2D" modified="2018-10-10" version="1">MYLQGGPGFGSPKTGSIGGWIAELAKTHRVILLDQRGTGMSSPLSARNITAVGDAQLQAEYVELFRADSIIADAEAVREVLLADRTDKRWSTVGQSFGGFLTLSYLSFAPQSLRDSRITAGLAPIRTTVDNVYEHTFDRMAERNKEYYSWFPEDAALATRIAEHLRTHEEFLPTGERLTDHRFQMAGHYLGGRWRERGLHYFLETAFAEGDDHLSDQFLSSMSGEVSFLANPLYALMHETIYADGPADGNLPGIPGFTVSPSPAPTNWAAARVAAKRPEFAPDAETLFFTGEHIFPWYYEEDPALRPLAEVAQLLAEKKDWGRLYDHEQLHRNEVPVVAAAYTPDIYVDYENSMETARWVGNTHVWTSKTHHHDGFGSDPLTILGHLKNMLAEVHNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0I9</accession>
    <name>A0A2Z5R0I9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type I restriction-modification system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87986">
        <property type="protein sequence ID" value="BAV87986"/>
        <property type="gene ID" value="RA11412_1687"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1687"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="241"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="470"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="996" mass="111742" checksum="5CEC2D613BC7E3F0" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0M6</accession>
    <name>A0A2Z5R0M6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron-dependent repressor IdeR/DtxR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Metal-dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I6I94_07690</name>
        <name evidence="9" type="ORF">RA11412_0120</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86419">
        <property type="protein sequence ID" value="BAV86419"/>
        <property type="gene ID" value="RA11412_0120"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0120"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT88415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="231" mass="25711" checksum="BF124AD5465658D4" modified="2018-10-10" version="1">MTDLIDTTEMYLRTILELEEEGITPMRARIAERLEHSGPTVSQTVARMEKHGLLSVEPDRHLALTDAGRKKAVEVMRKHRLAERLLSDVIGLDIEYVHDEACRWEHVMSDHVEKRILAMLNNPKFSPYGNAIPGLEELGVESEHNDERTVPMSIAARDSGPEDRFTVSRFPESIQTDIELLKLLADAGISFGASVSVLAGKDDDVIVRADGEETSLSLDEDVANAIVVKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0N7</accession>
    <name>A0A2Z5R0N7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_01080</name>
        <name evidence="5" type="ORF">RA11412_1755</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88054">
        <property type="protein sequence ID" value="BAV88054"/>
        <property type="gene ID" value="RA11412_1755"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1755"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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        <property type="entry name" value="AAA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
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            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="69"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="345" mass="37185" checksum="D261D3C0C3828B69" modified="2018-10-10" version="1">MAKEDVSGKTARGNGDGAALEIADLVKEFKPSRSFREKNPERLTERGMHRAVDGVSLQVYPEEVTVLLGANGAGKTTTLACAQGLLAPDCGTVKLLGENPLHASPELRAAVGIMLQDGGLPNAMRPIPLLHHVAKMYTHPASVDELVERLGIASFNGTTIRRLSGGQKQRVSLAAALIGRPSVLFLDEPSAGLDPQSRNVVFDIIREQRKAGVAIILTTHLIDDAQKLADYVYIIEKGKTVLEGTVPELVAGDGTARLHYTLNAHTPAREELLPVGLRGGVELIEHTHYTPGTPGEYELRGPLTPEHLSAFTAALTAHYIMPISLKMEPKTLEDVFLDISGRDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0P4</accession>
    <name>A0A2Z5R0P4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07625</name>
        <name evidence="2" type="ORF">RA11412_0140</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86439">
        <property type="protein sequence ID" value="BAV86439"/>
        <property type="gene ID" value="RA11412_0140"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0140"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="117" mass="13641" checksum="5D3953AF22821205" modified="2018-10-10" version="1">MTDQYLYQNAELPQCPVETTLEVISTRWGALIVRDLLNGPLRYKELQRSLGNISQKVLTENLRQLEARGILTRTVYEQVPPRVEYKLTELGQSMRTLFDALWAWGEHYQETVTQSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Q3</accession>
    <name>A0A2Z5R0Q3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium voltage-gated channel subfamily KQT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RA11412_1924</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88223">
        <property type="protein sequence ID" value="BAV88223"/>
        <property type="gene ID" value="RA11412_1924"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1924"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="PTHR11537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="10">
        <location>
            <begin position="88"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV88223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="266" mass="29701" checksum="CB70E87BE8271858" modified="2018-10-10" version="1">MSTRISTPIDGVLNILQMILWALFAVDYCVRLYLAPRRIYFLTHNLMNLAIVLLPAWRIVSFLAMLHMTANRQYKLLSELAVKLFGYTLIFVIMAALAVFSIEQDAPGALIKDIWTAYWWTLATLATVGYGDVYPVTVSGRVIAVVVMIYGVGLFGVITGALATWVIEKISGVTEEDHAATKADIEALHAEIAELKAMLAIRMGDGTVHRPPEELTQEFLASRRGAPDTAEDDTHEPEQPMELIEETKQTLTVIRQKIAVRLRRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0U1</accession>
    <name>A0A2Z5R0U1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_07445</name>
        <name evidence="3" type="ORF">RA11412_0190</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86489">
        <property type="protein sequence ID" value="BAV86489"/>
        <property type="gene ID" value="RA11412_0190"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0190"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="337" mass="35698" checksum="68F9B5D8A9AC41F4" modified="2018-10-10" version="1">MTPNDPHSPTGARPGAKARRAAEPYQQGRDHGNTQGLAYVHEPTVAFGDDFEAPQQARAPQYDDDEPTLSLGGRFPNGHEPAPEQFGSSAQNAAGPGVDATSGDEELAWLNTPTTGALHPDAAPAPDPHNANRSAPHGGPPEPLEAWEQPPEGVVAMAPLEAQREHFGRLQVFPGLMGWMVALSALSFFTWLAETIMVLPTGTLTHPIAETLQHFSEGEADALTFLITVGVIYLLAYLAGGYTAGRMARFAGAKQGVSVCLWQILGCATATIFTYVMPHAFSPGSYSPLAAQQFFGAGTISNGILALLSVIGVSFLGAVLGGMCGRIYHRRVEKYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Y0</accession>
    <name>A0A2Z5R0Y0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Magnesium and cobalt transport protein CorA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Zinc transport protein ZntB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_07270</name>
        <name evidence="7" type="ORF">RA11412_0230</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86529">
        <property type="protein sequence ID" value="BAV86529"/>
        <property type="gene ID" value="RA11412_0230"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0230"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV86529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="343" mass="38565" checksum="9037D1AE3D7A4013" modified="2018-10-10" version="1">MSYLTGAIYPTHGETVLNAPLETAVEAYQAGASAVALGYISPTDTELAHLQSIFKLHELAIEDSMLGHQRAKLERYGDSLLAVVRPAVYLDAEEEVHLGEVHLFVGRNYLVCIVQDKLRSPERVREVLGGFFAESDASIARLLHRILDNTVDRYMPVLSGLETDSDEIEDALFTDGGKNRGISQRIYGLLNQVIDFQRACKPLDSMLVRIVEDLRIGALDASPRPGATPRRVEDESVELQRQFRDVHDHVMQIRDRLEDLRTSLQNALTVHDTLVAQQQNEDMKRISAGAAILVVPTIIGSIYGMNFEYLPELKWEYGYPASLLLMVLACVGVYFFFKRRGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Y2</accession>
    <name>A0A2Z5R0Y2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpsA</name>
        <name evidence="16" type="ORF">I6I94_11035</name>
        <name evidence="15" type="ORF">RA11412_2099</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037235181.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88398">
        <property type="protein sequence ID" value="BAV88398"/>
        <property type="gene ID" value="RA11412_2099"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2099"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="13">
        <location>
            <begin position="11"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="14">
        <location>
            <begin position="208"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="283"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV88398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QQT89019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="361" mass="38318" checksum="1C1F7CCD51D7ACE3" modified="2018-10-10" version="1">MQKSEQRQVRKIAILGAGSWGTAFAKIAADSARENNTGAQVVLIGREASTMERCTQTRENARYFPGMKLPDNLLFTADAREGLTGADIVVLALPAQVLRSQLQLFARFIEPHAFLVSLAKGLETGTGMRMSQVITEELEEALAMRGVDIRAIGHIPHRVCVLSGPNLATEIMGEEPTASVIAARTLPVAEIVAKSCACSYFRPYTNTDVVGTEIGGLVKNVIALCVGMCEGRNYGDNSKASVMTRGLAETTRLAVALGGEPATMSGLAGMGDLIATCSSPLSRNHTAGRLLAEGVTPDRLGEHMSQTAESIKSAPVLAQLARRHGVEMPIVEAVVAVLTGRISVEQLAPLLLGRSLKHEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R176</accession>
    <name>A0A2Z5R176_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6318 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86639">
        <property type="protein sequence ID" value="BAV86639"/>
        <property type="gene ID" value="RA11412_0340"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0340"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046281">
        <property type="entry name" value="DUF6318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19843">
        <property type="entry name" value="DUF6318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6318" evidence="2">
        <location>
            <begin position="35"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="166" mass="18274" checksum="777C257CF8DE553A" modified="2018-10-10" version="1">MSPAVSTSSSSSASSEPAKSYKGEAKLEKYETSAGTYEPGTSEHPPRNVPKPIKPANMNENSVAGLYSTIAFYAASFQYFVTTGDRQYLDQVKTDEEEDLSDYDEMAQYIAGGVAWFENPKIVITLTTDQPTKSGSSYTWPSTVVLITVKMFITHKARRFLCLLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1A4</accession>
    <name>A0A2Z5R1A4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88330">
        <property type="protein sequence ID" value="BAV88330"/>
        <property type="gene ID" value="RA11412_2031"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2031"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="105" mass="11566" checksum="6F3260192B59086D" modified="2018-10-10" version="1">MKTIHILATAHGTDSAEGRAAINLVRVELDDMLRAHGGSQHTQYQVHEAYVDVQSPNVDEAAFALPNEELCVIVPILLSTGFHTQVDLRRAAKIVVLRRCVLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1E0</accession>
    <name>A0A2Z5R1E0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88498">
        <property type="protein sequence ID" value="BAV88498"/>
        <property type="gene ID" value="RA11412_2199"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2199"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021421">
        <property type="entry name" value="DUF3071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11268">
        <property type="entry name" value="DUF3071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="438" mass="46801" checksum="89C689CBE3F5057C" modified="2018-10-10" version="1">MLELRLVGVHDDGENLVLESADGTRFALPIDMNLRTSITKARRIQPARGLGTKGSFGPRDIQTRFRQGASVEEIAEESGWEPERVRRYEWPIVAERAHIIRAAQGVKVGRRSSASGLAQIPVTLASRIADVTAAHGFAEAAQDWSTRQKDNGQWSIEVDFALTPRDREELPARVMFPARWVYNPANQSLYASNEAAYFLMGNAEDEVYDTKKQEEEPQPSSQPKAPSSTGSGASSVADVPVAVATGVAPVDASRVSSSTIKGTSPDERKLNELLERARSVSRPGPTTQQLRVVAQPSTVTVTEDSDSANNTTDSSRHREQVRAQGAASQGAAHRGVSSPQDSADESPQEPVDDRDVASFSAGDGSFYGRRAGRETSSPERGTAGTTPSRAKNAGSVARKTAGPASEAPSAHPAVKAQAAPRTQVPRRVRACVSVPSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1F1</accession>
    <name>A0A2Z5R1F1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trk system potassium uptake protein TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88483">
        <property type="protein sequence ID" value="BAV88483"/>
        <property type="gene ID" value="RA11412_2184"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2184"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="58"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="172" mass="19177" checksum="68C7EA0D80FA692B" modified="2018-10-10" version="1">MIAARVARETFKVKNVVARVYDPNRAEFFQRMGIPTVAAVRWSTDQVLRRILPEQAIRGDYREASGRLILTELPLHEEWAGHALVDIEAATGARIAYITRFGEGMLPRPDTSYQQGDTVHAMVRTDEATEIARILSQAPKDTEGERHDPRDAWAGAFAAEPAAVKSDNPHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1F3</accession>
    <name>A0A2Z5R1F3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06415</name>
        <name evidence="2" type="ORF">RA11412_0420</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86719">
        <property type="protein sequence ID" value="BAV86719"/>
        <property type="gene ID" value="RA11412_0420"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0420"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="381" mass="41896" checksum="6F9ADEBA2BAD8B93" modified="2018-10-10" version="1">MNISNWGTVLLFGVFTVFCYGVVIGVLPRMRGPGARKYAVQAVGMFLAALLTLLTVGAYLNLQNRWYPTLESIFADPHASASTSTYGFFPGNPSNAPGIELSSEQKDAYTNPALRAAFEERRASGGNGPLQLYIPDSAGRSIRTLVWLPASYLDSPERVYPVVLAFPGYPGMPDVYENFVPALDRAVANGTVGETILVVPDVFYAGVDTECVDGDPNTSPTPHTESFLTDSLIPFMKRNLRVPTTANGWATWGYSAGGYCALMLPVRHPDLVGAGVSFAGYFKPRYEPGQQWRSEDDNEYDLARILREKRPAVRLWYFTAADDTTVTAELADATRGISQPSMLSVVTIPAGGHRFDVWHPNDWRALAWLGKYQWFKPGGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1H8</accession>
    <name>A0A2Z5R1H8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Globin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Hemoglobin-like protein HbO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_11240</name>
        <name evidence="3" type="ORF">RA11412_2052</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88351">
        <property type="protein sequence ID" value="BAV88351"/>
        <property type="gene ID" value="RA11412_2052"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2052"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019795">
        <property type="entry name" value="Globin_bac-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01213">
        <property type="entry name" value="GLOBIN_FAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="156" mass="18266" checksum="A6F64E29C594BEA6" modified="2018-10-10" version="1">MSQYSANQPGEQVSIYEQVGGEETFDKLTRRFYALVKADPEFSAMYPDSDPFPPEHLTEEQTAKIEANDTDHFDAAARRLKMFLIQYFGGPSTYQEQRGHPRLRIRHNPYPIGAKERDTWLKYMRQAMDTLDLPMMIDATMWDYFERAARAMQNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1M5</accession>
    <name>A0A2Z5R1M5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mycothiol system anti-sigma-R factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsrA</name>
        <name evidence="3" type="ORF">I6I94_10415</name>
        <name evidence="2" type="ORF">RA11412_2264</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88563">
        <property type="protein sequence ID" value="BAV88563"/>
        <property type="gene ID" value="RA11412_2264"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2264"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024020">
        <property type="entry name" value="Anit_sigma_mycothiol_RsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014295">
        <property type="entry name" value="Anti-sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02949">
        <property type="entry name" value="anti_SigH_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03988">
        <property type="entry name" value="antisig_RsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="86" mass="9407" checksum="6A8B5E8D1DF475BB" modified="2018-10-10" version="1">MEKTEDCGGNPCSEQLKSIYEYLDGALSAEEIAQLQEHLDNCAHCAEAKNLEELVRAKIKSSCAQQAPEALKTKLMGYIDELCATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1P8</accession>
    <name>A0A2Z5R1P8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88593">
        <property type="protein sequence ID" value="BAV88593"/>
        <property type="gene ID" value="RA11412_2294"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2294"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="224" mass="23164" checksum="A6B7FE186AC28B14" modified="2018-10-10" version="1">MGILLILVSIVGVIAVIQLNNHTTQYYAAKSDIHVGDKITSDMLTPVDANLGSSSERYITSEEINKGDLMATRYIASGEIIGKDSTGTNVRENRRLVTVTIDRGSASALKAGEQVDVWAVQRDTVVATAPQPSPQPSASASSDSRDNPSASASPSSESQGSNGSSPIVSGAEISSISKEESVLGANGKATVQLWVNPNAVSSIVEANGSEAKITLVPVALGRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1R4</accession>
    <name>A0A2Z5R1R4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ThrE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88638">
        <property type="protein sequence ID" value="BAV88638"/>
        <property type="gene ID" value="RA11412_2339"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2339"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="2">
        <location>
            <begin position="35"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="182" mass="20074" checksum="4701C3376A949C24" modified="2018-10-10" version="1">MEQHNDKAYTDTNTYSIYLGSSREQHKFIVAQSQVVLRLGRILMKSGASAYRIKASMARLAKAVGLDEHHAQVTFTEIATTAYGNGNFRTEVAEQRTMGINSHKIDLLGNFISELPERITPQEANAELERIDSMPHLYKRWMLALASAVACAGFAFLNRGGLIECSAVLLPPGWGSFCVPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1V0</accession>
    <name>A0A2Z5R1V0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gsr3654 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86859">
        <property type="protein sequence ID" value="BAV86859"/>
        <property type="gene ID" value="RA11412_0560"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0560"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021111">
        <property type="entry name" value="Hexamer_Tyr-coord_heme_pr_HTHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038125">
        <property type="entry name" value="HTHP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11534">
        <property type="entry name" value="HTHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="84" mass="9135" checksum="709C47DD726E6990" modified="2018-10-10" version="1">MSQRLPAEELTGIPGGTLITKTPEEGRQLAMLIARHTIHQIQPNPDALKAGRPEYAVDPDSLTAAAQVVAIEFQTIAAANNYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1V8</accession>
    <name>A0A2Z5R1V8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88524">
        <property type="protein sequence ID" value="BAV88524"/>
        <property type="gene ID" value="RA11412_2225"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2225"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015315">
        <property type="entry name" value="DUF1963"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035948">
        <property type="entry name" value="YwqG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09234">
        <property type="entry name" value="DUF1963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103032">
        <property type="entry name" value="SSF103032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="209" mass="23848" checksum="68E47BD8DDB29AC7" modified="2018-10-10" version="1">MNTIFERVKHLNHLLSQQDRKPTVRIIPRAVQGTVSVTASKCGGVPYLPAGAQAPTNQDGKLLGMVAQINCAELPKNELYPKTGILQFWLDPYDELGLGIDLKNPVSQVNTRVIYYPHHRDTNPCAHTLVMPDQEKQTEMEFMAWPVHVDQGWEIGLSFEEASEGITPQNWWVYQSRFVELWNELYPSSLSVILRVLMHTRPQMRNARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R206</accession>
    <name>A0A2Z5R206_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_09740</name>
        <name evidence="3" type="ORF">RA11412_2424</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88723">
        <property type="protein sequence ID" value="BAV88723"/>
        <property type="gene ID" value="RA11412_2424"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2424"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="200" mass="21832" checksum="850CDF43B2E6B487" modified="2018-10-10" version="1">MIDTVKPLRSDAQRTAAAILQAAERVLRHDPTASLEQIAAAAGVTRTTVHRRFASRQVLIAALQASAIEHFYDAFEAASPETAPPPVALHRLTVNVMRTKSNWGYALGILSEDDPAVITKRRTVLARLEVLFQRAQHDGLIAPDVNLDWAQRMYRAMVDEAVKDLEPAASPQGVADTRANEAELDRLATLILHTLLSGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R238</accession>
    <name>A0A2Z5R238_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3107 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_09980</name>
        <name evidence="1" type="ORF">RA11412_2363</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88662">
        <property type="protein sequence ID" value="BAV88662"/>
        <property type="gene ID" value="RA11412_2363"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2363"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021456">
        <property type="entry name" value="DUF3107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11305">
        <property type="entry name" value="DUF3107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="75" mass="8260" checksum="68533B39FC4B308B" modified="2018-10-10" version="1">MEIKIGIRHISREISIDTNETAEKVRSKVTDAIHNGTTLEITDEKGATTFIPGAQISYVELGTEEKRHIGFGFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R285</accession>
    <name>A0A2Z5R285_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-galactopyranose mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88586">
        <property type="protein sequence ID" value="BAV88586"/>
        <property type="gene ID" value="RA11412_2287"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2287"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008767">
        <property type="term" value="F:UDP-galactopyranose mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015899">
        <property type="entry name" value="UDP-GalPyranose_mutase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03275">
        <property type="entry name" value="GLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLF" evidence="1">
        <location>
            <begin position="151"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="398" mass="45562" checksum="E38B5F9DC728A5CB" modified="2018-10-10" version="1">MTADLVVVGSGLFGLTIAEQAATELGLKVALLDRRSHIGGNAYSENEEQTGIEVHRYGAHLFHTSNERVWEYVNRFTDFTNYVHRVYTRHDGVVYPMPINLGTINQFFNAAYSPAEAKALIAEQAGELAGTDPQNLNDKGISLIGRPLYEAFIKHYTAKQWQTPPEELPASIISRLPVRYTYDNRYFNDKYEGLPVGGYTAWLERMAAHPNIEVRLNTDFFSGDHEYSREKVLGQVPVVYTGPVDRYFDYTEGDLSWRTIDLEEEVLPIEDFQGCSVMNYPDADVPFTRIHEFRHFHPERDYTKDATVIMREYSRFANKGDEPYYPVNTSVDREKLLKYRDLAKGRRTCCSADAWAPTSTSICTWLSDPRCRCSTIRSARILLRAPRSNPAVWTHNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2D1</accession>
    <name>A0A2Z5R2D1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88631">
        <property type="protein sequence ID" value="BAV88631"/>
        <property type="gene ID" value="RA11412_2332"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2332"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="49" mass="5349" checksum="439A56B8AB38F109" modified="2018-10-10" version="1">MYRAAHPDADVTAEFAAFDRDTPAAVRAGHRHSQRVKPPMPSSCSPVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2K7</accession>
    <name>A0A2Z5R2K7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
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                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TIGR00092"/>
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    </dbReference>
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        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="68"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="341"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="77"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="426" mass="45963" checksum="384AC8BA419EDA17" modified="2018-10-10" version="1">MQKTLLNRTPLGEEETWGVSLCGCGVSCGALYTLRLHCRMVGSCACTLAVSAVRVTIGTDFEGFSVALTIGIVGLPNVGKSTLFNALTRNTVLAANYPFATIEPNIGVVNLPDARLNRLAEIFGSERILPATVSFVDIAGIVKGASEGEGLGNKFLANIREAHAIAQVVRAFDDPDVIHVDGKVDPASDMETINTELILADLQTLENAIPRLEKAVKIKKGDAAQLATYKQAQKILEDGNTIFSRAAAEKLEMAHLKELNLLTAKPFIYVFNADEGVLASEEKQAQLRELVAPAEAVFLDAKLEADMVELSEEEAREMLEMSGQDESGLDKLARVGFSTLGLQTYLTAGPKESRAWTIYKGDTAPQAAGVIHSDFERGFIKAEVVSFDDLDAAGSMNEAKARGKVRMEGKDYIMADGDVVEFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2W5</accession>
    <name>A0A2Z5R2W5_9MICC</name>
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        <submittedName>
            <fullName evidence="4">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_09355</name>
        <name evidence="3" type="ORF">RA11412_2507</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88806">
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        <property type="gene ID" value="RA11412_2507"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2507"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041497">
        <property type="entry name" value="Thump-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18096">
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    </dbReference>
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        <property type="entry name" value="SSF53335"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Thump_like" evidence="2">
        <location>
            <begin position="439"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="529" mass="56397" checksum="46B5C1CAFFDDF5A2" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R334</accession>
    <name>A0A2Z5R334_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88980">
        <property type="protein sequence ID" value="BAV88980"/>
        <property type="gene ID" value="RA11412_2681"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2681"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="39" mass="4027" checksum="419DE3F39B24A36D" modified="2018-10-10" version="1">MNSVAAMGCSVLLALTVPSLIDAVRLVPGEWVRQGAVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R353</accession>
    <name>A0A2Z5R353_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89010">
        <property type="protein sequence ID" value="BAV89010"/>
        <property type="gene ID" value="RA11412_2711"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2711"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="105" mass="11120" checksum="013B3119635C39B6" modified="2018-10-10" version="1">MASPSAPTSPMKDNTDYILAVEQLAHGAFAERRAAADTLVGLADDWLSNATISAAERDAAAQGAADALCAYIRTPLPSEQETENPRNTGRTRPKKNGHSLTVKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R389</accession>
    <name>A0A2Z5R389_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88986">
        <property type="protein sequence ID" value="BAV88986"/>
        <property type="gene ID" value="RA11412_2687"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2687"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="194" mass="21854" checksum="2601827E8F4A8865" modified="2018-10-10" version="1">MPYLKSYGIEPEDFLPASCRRALATGEDITLNPSQYLDFLRTIDTTIPDKELLKLGTQSSLKQWVPAIFGALAADNGWEGLARFERYKKLTAPIDMHTTHEKNRCRVEFAFAGAERALPRSGVLLEQVILLTLMRTGTGRYIVPLFVEAPFEYSAEYTEFLVLPRVRPAATHWYSQLPICCCPFGKRITSCGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3R5</accession>
    <name>A0A2Z5R3R5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Type I-E CRISPR-associated protein Cas7/Cse4/CasC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cas7e</name>
        <name evidence="2" type="ORF">I6I94_01820</name>
        <name evidence="1" type="ORF">RA11412_1570</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888673.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87869">
        <property type="protein sequence ID" value="BAV87869"/>
        <property type="gene ID" value="RA11412_1570"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1570"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010148">
        <property type="entry name" value="CRISPR-assoc_prot_CT1975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09344">
        <property type="entry name" value="Cas_CT1975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01869">
        <property type="entry name" value="casC_Cse4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="377" mass="41012" checksum="297555FCFE086B9F" modified="2018-10-10" version="1">MSFFVDIHALQTLPPSNINRDDTGSPKSAIFGGVSRQRVSSQAWKSVIRRNFEEHLDRSEIGVRTRQVADMIVDRITNISPDFDPDKAESAVVDAFKAAKIKLEKPKAKKGEENTGRAVSGYLLFLSNQQITRLANAIIEANGEKIPAKEVKDILDTKHSVDIALFGRMLADAPDFNVDAACQVAHALGVHGSEPDFDYYTAVDDVIRESEDETGAGMIGTIEMASSTLYRYANINVDALKTNLGGSAAATVEATLAFIRAFIDSMPTGKQNTFAARTLPEAVIVTVREDRPISYINAFEKPVTEKSSEGRRLAAAHALATEAANIREAYGYEPKVSYVVALGELREALSNMGETVTLKELLASLESQLTELVGQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3Z7</accession>
    <name>A0A2Z5R3Z7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">leuS</name>
        <name evidence="16" type="ORF">I6I94_00685</name>
        <name evidence="15" type="ORF">RA11412_1860</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88159">
        <property type="protein sequence ID" value="BAV88159"/>
        <property type="gene ID" value="RA11412_1860"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1860"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="13">
        <location>
            <begin position="50"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="14">
        <location>
            <begin position="231"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="429"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="677"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="597"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV88159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QQT89188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="831" mass="92269" checksum="841CEE2CD3835B12" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4A7</accession>
    <name>A0A2Z5R4A7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA decomposition enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88429">
        <property type="protein sequence ID" value="BAV88429"/>
        <property type="gene ID" value="RA11412_2130"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2130"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="240"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="416" mass="46544" checksum="0328DE9F2E8B428F" modified="2018-10-10" version="1">MSDTTYTSQATTAPSSGAGMSHAYNLSKAVHQLQTQLQGKWPTGHSVFHPRFTPLRELRDKLHITDPNGVPTYCDPENISLKSLEDGIMMHCIILDKTKGLLAITEDNGDPKPYRGKYVTNYINYVFRYLSIDTKVNISEMDGYPNINTKNAKNRSLLDILDFLYEHQDSIVHALSFNPLDDLQICFFPILHPGFNFPRDTPQQILDWYTTSSYKIGLFSSPLENKNMGIIKKLNDYSNVIAEGVAGCGKSHMLESLKDTTINGGYGPENVTTVVFHPSTSYEEFVSGLRPNFAYGTETPDFISHEGIFLQACAKAVRLARSYAAHRARTGADTSLGQDPTHREAPAHLLFIDEINRANTSRVFGDLMLVLEKSKRHNYATDTNGDWQNHMHGALVANYDREDSSSSAQPVTIPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4J6</accession>
    <name>A0A2Z5R4J6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pribosyltran domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88599">
        <property type="protein sequence ID" value="BAV88599"/>
        <property type="gene ID" value="RA11412_2300"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2300"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="49"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="104" mass="10538" checksum="9B2E3E91EFD4A1E1" modified="2018-10-10" version="1">MGVRVSVAPVLRVRASWASFAGAGSAGGQKGLSASERARRMRGMMRVSGTAPAGMLCLVCDDVLTTGATAVEAVRALRQAGILPLGVATLASVPLKTQGDELVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4M2</accession>
    <name>A0A2Z5R4M2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88669">
        <property type="protein sequence ID" value="BAV88669"/>
        <property type="gene ID" value="RA11412_2370"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2370"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="238" mass="24462" checksum="2962B3E6FFEE1268" modified="2018-10-10" version="1">MTQTPPSSYLASRLAQASGQPLPNGEALAAFTRRDDALAAFDVLSAAGFPVTALYLVNEGVKQVEYPLQRSYGRMLLSSLMWGIIAGLGCAALTIGDGSDFLGRAASTVPLSVAIFMVWTLVSIRRGGNSRYPMRGEAIPERTTMYALSEYAGQARMILRDTPGFAQAMRSVHGAAYGGGNATQQPGTTGTAAPRTGSTPSAPAGTAGTAAGTESEHAKTPPAPSAATGGAPHRMRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4S4</accession>
    <name>A0A2Z5R4S4_9MICC</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88809">
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    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2510"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016403822" evidence="1">
        <location>
            <begin position="30"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="138" mass="14554" checksum="11A719B4DC60E972" modified="2018-10-10" version="1">MKMMRKLGTALSAVSIVAASCITTAPAVADDENQQAPCQDVEVVFARGSGQPLLADVESEAVGEQKTDKAKHVKEAKRVKELAASNAQTLGLTQNFYELGTRHINGAHYPAHPIQGFTSLLNAGIRPRAAGTSPTSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R522</accession>
    <name>A0A2Z5R522_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08310</name>
        <name evidence="2" type="ORF">RA11412_2760</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89059">
        <property type="protein sequence ID" value="BAV89059"/>
        <property type="gene ID" value="RA11412_2760"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2760"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="233" mass="25782" checksum="720E4CDF5781BF78" modified="2018-10-10" version="1">MAERAHEISSKHGTAEHIYHPRIRSYGRRVEAALPGTLTLIAALAFLGYKRPALPYTIVTLLIAFCAGISLYSVLKPTIVALTDTHVLRARLIGWKAVPLKNIDHTILVEKLYPKQAHGKKTTGMGRLRYRPAPAMWAIGKNKKPLMRLDGRVWDAKTMRTVSSKLSEQTTVYQKANVLDIDKLHPHLITFNELHPGWRSATIAVVAALVILLLGAGALLPEETARAIHLISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVB8</accession>
    <name>A0A2Z5QVB8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86316">
        <property type="protein sequence ID" value="BAV86316"/>
        <property type="gene ID" value="RA11412_0017"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0017"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="85" mass="9103" checksum="48AC7F452BCF16E8" modified="2018-10-10" version="1">MTGGFGAVLCVVLNTDAAGAQRVVEALKLWTPATSLGGVESLVERRRRHGNEPDSIPESLLRLSVGIENVDDLYDDLVNALKEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVD5</accession>
    <name>A0A2Z5QVD5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_07940</name>
        <name evidence="3" type="ORF">RA11412_0054</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86353">
        <property type="protein sequence ID" value="BAV86353"/>
        <property type="gene ID" value="RA11412_0054"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0054"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="440" mass="45250" checksum="B58F68C99EE9296D" modified="2018-10-10" version="1">MTPNTPASAPKNPLRANTAFQRTAAALALNQLSDAMSLITITFMVIAMNGSPELASLVLFCCSFTAITAGIISGTIVDRMTPRRALILSCATQTLGWVGVLALSMSGSHSIVVLTLILVLLTAASQLDYPSEQKIIAATVPVTDLGRASAIGQARESAANLFGAPIAGFIAGISLHLLLAAQGLLNLVALAVVPSRRSIDQYRKTKNNSDDPAPGGSTVSATDSAAPETTSGILADFKDGWRRVLADKTLLAIAAVTGIANFATTGIPLTLIYYYQSAGFSALWVGVLMGAFGAGVLTGSTLVGFLTDRLALSTLGICAVGTIAAGQLAAVFIHPTFWATAVVFALAGVPLPAFNASIMAYVNATTDEAAIGRVHSALGVPVMALMPAATLAAGVLFGAWGAGTTLLFFAVFMVLSLVLMLVQPGLRTLPKLSELEDVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVD6</accession>
    <name>A0A2Z5QVD6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86358">
        <property type="protein sequence ID" value="BAV86358"/>
        <property type="gene ID" value="RA11412_0059"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0059"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="90" mass="10205" checksum="4529A454066F24E4" modified="2018-10-10" version="1">MTVTSHKKWTPTFVKNGEVAPPRANRDEVLHEIRTSYYNSISAQSQARQTARPQESAPPQQSWARRYADQLLGFIGRKSHSAPKSLGERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVE6</accession>
    <name>A0A2Z5QVE6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07885</name>
        <name evidence="2" type="ORF">RA11412_0068</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86367">
        <property type="protein sequence ID" value="BAV86367"/>
        <property type="gene ID" value="RA11412_0068"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0068"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033777404" evidence="1">
        <location>
            <begin position="32"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="316" mass="34373" checksum="22E12B14A7DB9224" modified="2018-10-10" version="1">MRTGKRSLLAAAALMLALSGCGGIDSGQAGATQQEGTSGDEQAVLEYLSGPAEINTALQKAGAQCMREAGFTSGGWEARLRAHESISEISGRFESEEDAKFRGYSTTLWIPETYPTLSYLSSAQRQAMYGSRPQLDSRNLRPQKYDWGKSTAPSAPNLFTPIAVTADPAEYGCKGIAIQKVFGSLENYATYEALYPELRQLGARSAEAARKVHDENRGAYQQCLEDAGFNNVGAPPLVAERAEAIAGLYRGEGVLTNAKEQQLAAADYACDKKLHYFEKLDQAVLSANREWVQQNAGRIQQVKRIRDEATARAKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVG7</accession>
    <name>A0A2Z5QVG7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86385">
        <property type="protein sequence ID" value="BAV86385"/>
        <property type="gene ID" value="RA11412_0086"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0086"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025584">
        <property type="entry name" value="Cthe_2159"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14262">
        <property type="entry name" value="Cthe_2159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016435909" evidence="2">
        <location>
            <begin position="25"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="395" mass="39689" checksum="42860699FE6CDEAC" modified="2018-10-10" version="1">MLKTVTSVTLIAALGLTGCSTASGTTLTSGTSTVHSAVSGTTAGTSTSNTAAGQTLDAQTHYTNEDLTWDSSDEKTIDLANPAATDGVSVENGTITITSGGTYRLTGEYSGQVKIDAAKTDTVRLVLDNAKITNSTGAALNVVSAAEAIIYTAAGTTNTVADEANYTATGDDDPDAAIYSTANLTLAGEGSLSVEGAYEEGIHTTGGLVIASGTLEVNAANTGIKGKDYVDITGGIVNVTAAQDGIKSTNTDDESKGFTRLSAGSVTVSAGDDGLKAPHTLEISGGTLNIEKSNEGIEAQYINILDGDVTVNSTDDGINASLKDSSSDTSSDTTSGTAPAGQQTQQNQNGQVQQAPAGGEPHPAVVRAALGKTRICPSLPLTVLCPAVAAASSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVH9</accession>
    <name>A0A2Z5QVH9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidophosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86376">
        <property type="protein sequence ID" value="BAV86376"/>
        <property type="gene ID" value="RA11412_0077"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0077"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="3">
        <location>
            <begin position="23"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="333" mass="35682" checksum="7F79EFEF5117405D" modified="2018-10-10" version="1">MIRPDGKLTHDLDPVDHGPKDACGVFGVWAPGEDVAKLTYYGLYAIQHRGQESAGIATSNGKRISVYKDMGLVSQVFDEATLSSMPGDHAIGHARYSTTGASHWANAQPTLGTTPHGTLCLAHNGNLTNSADLYDRLLAKNGGKPPAFGELAQGNTTDTALVTALLAEHDFASLEEAVLDLLPTLRGAFCLTFMDETTLYAARDPQGVRPLVLGRLERGWVVASETAALDIVGASFVREVEPGELIIIDEDGLRSQRFAPAQPAGCVFEFVYLARPDTTISGRSVYESRVEMGRQLAREHPVEADLVMPTPSPVCPPRSVTRSSPASPSAMAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVI0</accession>
    <name>A0A2Z5QVI0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyphosphate polymerase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07810</name>
        <name evidence="2" type="ORF">RA11412_0091</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86390">
        <property type="protein sequence ID" value="BAV86390"/>
        <property type="gene ID" value="RA11412_0091"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0091"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VTC" evidence="1">
        <location>
            <begin position="25"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="279" mass="31655" checksum="8F16A921ACCA3069" modified="2018-10-10" version="1">MEIIPSYWQSITLNDLNNKAAMQTRMDRKYIVDADYAASVLAELPAEASVLEIEGQREFAYDSVYFDTPNLVSYYAAATDRPDRFKVRTRSYLDTNTCFLEVKTEGERAMTVKERIPYSIDDRDKLTEEGRQYVNEALYGILDTPAIEFEPVISTGYRRTTIYLPASEQNPVDSRLTIDRNLTWTPLSDHALYAGVTRENYHGHKVGVEYTIPGTVIIETKSGTAPSVADKHLWRAGIRPVKISKFGTGLAALNPQLPSNKWHRIIERWMNLVPAKVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVI9</accession>
    <name>A0A2Z5QVI9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_07820</name>
        <name evidence="3" type="ORF">RA11412_0087</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86386">
        <property type="protein sequence ID" value="BAV86386"/>
        <property type="gene ID" value="RA11412_0087"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0087"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025584">
        <property type="entry name" value="Cthe_2159"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14262">
        <property type="entry name" value="Cthe_2159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340085" evidence="2">
        <location>
            <begin position="35"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="496" mass="49852" checksum="20D9A3F8468631B9" modified="2018-10-10" version="1">MKKTTVKTVASVTLITALGSTGYLAANGAPPVAAAPNAAAVQKLDAQTHYSDEDLKWDSSDEEAIDLANPAAADGVNVNNGTITITADGTYRLSGEYNGQVKIEAGKSDTVRLVLDNAKITNSTGPAINVAGAGEAIIYTASGTANTIADGANYAAKGADDPDAAIYSTANLTLAGEGSLSVKGSYKAGVHTTDGLVIANGTLDVNAAKAGIKGKDYVDIVGGTVKVTAGQDGIKSTNTDDENKGFTRLSDGSVTISAGDDGLKAPRTLEISGGTLNIEKSDEGIEGQYVNVLDGEVTVNSTDDGINASLPAADKVDDDGDADQEQEPADGAGAAPVDADVNISGGTVVVNADADGIDTNGNAVFTGGTIIVNGPIAGGNRAIDFDGKLLLNGANVTTGSAAEKFQTPSTESTSGHLKIVNNAALTQGKTVQVADSSGEVVANYKITKSGVQLVLVSNKNIVKGQDYKVYVASGDVDIDSTDVANGATELGSFTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVK5</accession>
    <name>A0A2Z5QVK5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoenolpyruvate carboxykinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86334">
        <property type="protein sequence ID" value="BAV86334"/>
        <property type="gene ID" value="RA11412_0035"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0035"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004611">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEPCK_GTP" evidence="1">
        <location>
            <begin position="2"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="198" mass="21690" checksum="7A850B919BC9D243" modified="2018-10-10" version="1">MPLSAIVLGGRRKTTVPLVSESDSWEQGVFRAVTLSSETTAAAKGAVGVVRRDPMAMLPFIGYNAGDYFQHWIDLGKKHGAENMPKVYYVNWFRRTPDGGFAWPGFGENSRVVKWIFDRLDGKGGGTQTFLGTVPTKEDLDLTGLSISDEELNAALAVSKDEWVAELPGIDEWLAKFGDKLPAEVKAERDALAQALEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVR4</accession>
    <name>A0A2Z5QVR4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methionine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_0184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86483">
        <property type="protein sequence ID" value="BAV86483"/>
        <property type="gene ID" value="RA11412_0184"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0184"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV86483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="251" mass="27445" checksum="C02B49F8268B76B3" modified="2018-10-10" version="1">MVGNETANQVLKDEAAKQGITIEYSEFTDYAQPNPAVDAGDNDMNRFQHIAYLANYNVSSGKDLQIVGSTNIYPMAIFSKKHKKVDEIPQGGTIAIPNDSVNEARALLLLKAQNLVTFKSEVHTPTHNDIDTGKSKVKVTPVDAAQTVVSLDSVDAAVINNTFLADAGLNPSDALAQDDPNNPDARRYVNLFVAQKDKVNDETYKKVVEIFHSKTVQDAVKEDSKNTAVEVNLSQDELKKALENEEAALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVU2</accession>
    <name>A0A2Z5QVU2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86500">
        <property type="protein sequence ID" value="BAV86500"/>
        <property type="gene ID" value="RA11412_0201"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0201"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="284" mass="30442" checksum="860F9A4B589357F4" modified="2018-10-10" version="1">MIDQALKDAGAEPGSEVFLMGHSQGGMIAYNTANSTEFAKKYNVKGVYTEGSPLSGLPAKRRDFSVAYVEGKEPVPDSLGPRKKGKGWTPDERDTVINTSNSGMDGHAAVEYEKALNDNPKGHKDLKQLKDFFSNGDYEAQQIGVYSASTMPDGTSDLANSAMQIGRYEEAIITSKAEGANAHIHQAGADYARGERLPDILDPRYRDQEAGESSASTPNMRSDSLVERYQDAITLRPPQPSQSFAESSQRATPSAPQGSLSWSDIVESSGVVGSGVSPTQMVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVU6</accession>
    <name>A0A2Z5QVU6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86502">
        <property type="protein sequence ID" value="BAV86502"/>
        <property type="gene ID" value="RA11412_0203"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0203"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="53" mass="6055" checksum="615A25861A6B7F14" modified="2018-10-10" version="1">MRKDTGPCGPNRHHHCPAVVTNMHKPFGDARQLFKFNVYGAVTHDFLLRVSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVV1</accession>
    <name>A0A2Z5QVV1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86516">
        <property type="protein sequence ID" value="BAV86516"/>
        <property type="gene ID" value="RA11412_0217"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0217"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="121" mass="12172" checksum="B1F3D7652778979A" modified="2018-10-10" version="1">MAVVPKTPQQIAGEQAAQTSMTLGVIGLVLLLTGLGGVITLILGIIGVKKAAEAERQGVPATGGKVMGWISLIGGGLLTILTILAIGFIIVVFIAAASAGSSSTGNYLDLAYTFAPLMSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVV4</accession>
    <name>A0A2Z5QVV4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Osmosensitive K+ channel histidine kinase KdpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86424">
        <property type="protein sequence ID" value="BAV86424"/>
        <property type="gene ID" value="RA11412_0125"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0125"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="196"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="273" mass="29597" checksum="F3804D6511197652" modified="2018-10-10" version="1">MGRRPLERIPFTLSLRTQLVLVTSALIALAIVVTSLVAISALRAQMVHQLDDEMKANSANLLSLVSNNSQHPVQEATLGSYHVYLLDEHGNTLYALSPDTSSRDEPQVTGWTADKVRKNNGVGTTVNSVEGSKDWRLLPMTLNNDTSVNGVHATSMVVALPLEQTNQVVALVGVLTFAFGLATLASAIAMTWVIVTRTFEPLARVEQTAAKIAKGDLSQRIEDYNPGNEIGSLATSLNTMLAQIETSFNAQAKSEAKMRQFVGDASHELRTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVV7</accession>
    <name>A0A2Z5QVV7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86545">
        <property type="protein sequence ID" value="BAV86545"/>
        <property type="gene ID" value="RA11412_0246"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0246"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="5003" checksum="BE0840D087C65B38" modified="2018-10-10" version="1">MFEFDDKVKENKNGLFTGFDLIFEDNPFDQEIKKRILNNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVY7</accession>
    <name>A0A2Z5QVY7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Low molecular weight protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86551">
        <property type="protein sequence ID" value="BAV86551"/>
        <property type="gene ID" value="RA11412_0252"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0252"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="33"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="184" mass="20620" checksum="B6B7E31D47F4EE26" modified="2018-10-10" version="1">MDTVFDGTVFGKIITHPGIQYRQQFAHTRRNGNLILFVCLGNICRSPMAEYVLRHQAAERGLSHLVETASAGTSGWHDGEDMHRGTRAELKAHGIAADGFSSRKIRREDPAHYDLIIAMDDDNLAELERQFGRCPGKQFKLTDLIPDSGYRAVPDPWYTGDFTETFRLVSAAAEALLDRLETVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW34</accession>
    <name>A0A2Z5QW34_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylosuccinate lyase</fullName>
            <shortName evidence="11">ASL</shortName>
            <ecNumber evidence="4 11">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">purB</name>
        <name evidence="15" type="ORF">I6I94_07410</name>
        <name evidence="14" type="ORF">RA11412_0205</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 11"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86504">
        <property type="protein sequence ID" value="BAV86504"/>
        <property type="gene ID" value="RA11412_0205"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0205"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013539">
        <property type="entry name" value="PurB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08328">
        <property type="entry name" value="ASL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="12">
        <location>
            <begin position="33"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C" evidence="13">
        <location>
            <begin position="343"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV86504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QQT88362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="478" mass="52254" checksum="F8BB801950CFFEC6" modified="2018-10-10" version="1">MSHLENTLPSGRTDLSAGTLALGPLDGRYAPVTAPLTNYLSEAALNRDRIHVEIEWFIYLCEHAVLPGLTPLTDEQKSGLRAIVTEFNTDSVTELAEIEAVTVHDVKAVEYYIGRRLEALGLGHLVPLVHFGCTSEDINNLSYALGIKDAVENVWLPAARDLVQVLLDLAETGRDVPMLSRTHGQPATPTTLGKEMAVLAYRLKRQISHVAATEFLGKINGATGTYAAHYASVPGADWQAISRGFVEHLGLSWNPLTTQIESHDWQAELYSDVAHFNRVLHNLCTDVWSYISIGFFRQIPVAGATGSSTMPHKVNPIRFENAEANLELSNAIFDSLASTLVTSRWQRDLTDSSAQRNIGVAFGHSVLAISNVIKGLQRLDIAADVIAADLESNWEVLAEAIQMVMRAEAIAGTPGMENPYERLKELTRGHRVDAVRLKEFVGTLGLSTEAQERLSNLTPHTYNGIAAQLVDHAKDAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW60</accession>
    <name>A0A2Z5QW60_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86638">
        <property type="protein sequence ID" value="BAV86638"/>
        <property type="gene ID" value="RA11412_0339"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0339"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="39" mass="4175" checksum="8CB52F8C77FA97E1" modified="2018-10-10" version="1">MQADNNAAADPAPAKFSAARRLNTEVTILSISFVQIQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW84</accession>
    <name>A0A2Z5QW84_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="5">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86603">
        <property type="protein sequence ID" value="BAV86603"/>
        <property type="gene ID" value="RA11412_0304"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0304"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="274" mass="30019" checksum="26E161515D04B7B2" modified="2018-10-10" version="1">MDVQELNREVAPGVDVKAWTFNGSYMGPILHGKLGDVFEITLENNGSMGHSLDFHAGMVSPDNTMKTIAPGEKLVYRFEATGTGIWLYHCSTTPMSLHMASGMYGAVVIDPQDMDPVDHEYVLVQNETYLSNTGQTAENGNKLTEVSSEGIAAGTPTFTMFNGHATQYINQPLEAKKGERVRIWLMAAGPSKGMSFHVVGSQFDTVYKEGGYLLRRGKDPYGVTGGHSQALDLDSAQGGFVEMQFREPGTYTFVNHRFAEMERGAMGKIKVTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWL7</accession>
    <name>A0A2Z5QWL7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86808">
        <property type="protein sequence ID" value="BAV86808"/>
        <property type="gene ID" value="RA11412_0509"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0509"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="46" mass="5253" checksum="F4E46A08055196F2" modified="2018-10-10" version="1">MYHKESKKVQGIPNKLADAVLEAQQFLNPVISREAQGKSWNGKKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWM0</accession>
    <name>A0A2Z5QWM0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="309" mass="31670" checksum="A7022F6C14F62321" modified="2018-10-10" version="1">MSGRIIAAGGVTRWAHTLNGCLIFGMSTTYSELAERIMSGQTLSRDEIHELIVTSDGQDFALIEAASAIRRHEFRNMIAVHTDDEELAAALGTRSIAIGGYETLDLSADIDSEVLADKLAELGAGSATGITVKLPANAVPMTLMRVLAITRMAAPDKVLHLPDGYEEALRSLSSLAMHIVSAITISDDIERWPIINETLKAIKHGGIVIAGASGQDALAGYLRYLSELGVDLMGYREARGSACGSVDGGGCCGGHDHAESSAESSAGGCGCGSEGCGSSAQASESVEEPQPAAASASHGCGCGSGGCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWZ4</accession>
    <name>A0A2Z5QWZ4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_05685</name>
        <name evidence="1" type="ORF">RA11412_0602</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86901">
        <property type="protein sequence ID" value="BAV86901"/>
        <property type="gene ID" value="RA11412_0602"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0602"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="121" mass="13143" checksum="26F5C1197F6C0916" modified="2018-10-10" version="1">MTGRIRKLLSSCTRWVSREVRQEELNDFRVAVTDGSGGARIRLSGLLGNSALGICAVTVRTHGGRVNIILRQRLSNGVYSGSFDREFSVPAGVHEVTFGSGNAVIWRREQGRPGNAAVSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX06</accession>
    <name>A0A2Z5QX06_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arginine/ornithine antiporter ArcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86873">
        <property type="protein sequence ID" value="BAV86873"/>
        <property type="gene ID" value="RA11412_0574"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0574"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="98" mass="11086" checksum="D731CED72E164B49" modified="2018-10-10" version="1">MMLWILLALFVPGGRKAWSARADIDVKQLSLNLIWSFLSSAAAAVLMMGFPNILNESEPNQDEHTKLVMAALILAISITRSPIMIPCRRFRGWPCRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX28</accession>
    <name>A0A2Z5QX28_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-asparagine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86931">
        <property type="protein sequence ID" value="BAV86931"/>
        <property type="gene ID" value="RA11412_0632"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0632"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="8">
        <location>
            <begin position="36"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="434" mass="46566" checksum="8460313C06045047" modified="2018-10-10" version="1">MSAQKSTDAPTTAPPQEDAFAHEQEGLHKGLGARQLQMIAIGSAIGTGLFLGAGESLQKAGPILALIFAACGFFGYLILRALGELILHRPSSGSFVSYTREFYGEKAAFVSGWLYWLNWAVTAVADATAIAIYVNWFGRYNQFFYDLPQWLTAFIVVIITVSFNLISVKIFGELEFWFALIKILALLTFMAVGIWYLFFGQPIDGVQPGLPLITSSDGLFPHDALTTLIVVQGVVFAYAGIELVGTTSGETKDVQKVIPRAINAVVWRIAIFYVGSITLLCLLMPYTVYSDTESPFVTFFDKIGVAGTAPIMQLVVITAAASSLNAGLYSTGRILHSMGVAGSAPQFATKVSKSGVPVAGILLTGVVGLFGVVLNFFIPEEAFSVVVNIASFGTMASWAAIAFSHQKFLKLVGEGKYKRPSYRAPAGALLTGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX41</accession>
    <name>A0A2Z5QX41_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05275</name>
        <name evidence="2" type="ORF">RA11412_0693</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86992">
        <property type="protein sequence ID" value="BAV86992"/>
        <property type="gene ID" value="RA11412_0693"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0693"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT90000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="75" mass="8440" checksum="85A35BBD63E2C9EC" modified="2018-10-10" version="1">MAFHAEEFAQNFGQRVRRIRKEERLTQLELSYMVGVSDKTIRDIERGKSGPSFGSVLKTAEVLGIYLVVEGADHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX43</accession>
    <name>A0A2Z5QX43_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="6">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysS</name>
        <name evidence="9" type="ORF">RA11412_0716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6 7">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87015">
        <property type="protein sequence ID" value="BAV87015"/>
        <property type="gene ID" value="RA11412_0716"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0716"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="202"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="527" mass="58567" checksum="56204832499579D3" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXA4</accession>
    <name>A0A2Z5QXA4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative asparagine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87077">
        <property type="protein sequence ID" value="BAV87077"/>
        <property type="gene ID" value="RA11412_0778"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0778"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="464" mass="52306" checksum="3339819DA97F8895" modified="2018-10-10" version="1">MDALNPAINMSRVALGLCRNPPGWVRRVSYWENIMALPPATTVCEDEHGSVQNTSYFADALSLQDSTLSFSDVSQHVYTVLNSVLRRLAEGRTHVSADLSGGVDSTVISVLLAAQNVPFTAFHAGTDDKDNRDTQLAQKIAEHFAIDLIKLDSFTKSTAGFTIPDELRGFSEAPRAWHANLPHLTALVRSARERGSSIHCLGIGGDELFEPMPVQALLYFKQGEKMRAIKAISSVAAAARWPKVSTLRAAFSPETKQRELQRRLTRRGQNIPENIDAFSWFPNFTLPSWLSEEATEQVIELMRATPIPPEEEELDKYRFHIYGSLEFQGEVLRGMNEYFSETGLEFAAPYLEDDMIRSSLVYPGVLSGHGMSKPVILEAMKGTLPEFFYRDIYKSDYSFDLYQDYERSKENFLKMIGDSLLAELNLVDIDTVRTIANSPLGSSETLYDFERMTHMEVWLRENYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXD5</accession>
    <name>A0A2Z5QXD5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lanthionine synthetase C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87092">
        <property type="protein sequence ID" value="BAV87092"/>
        <property type="gene ID" value="RA11412_0793"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0793"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025410">
        <property type="entry name" value="Lant_dehyd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13575">
        <property type="entry name" value="DUF4135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4135" evidence="1">
        <location>
            <begin position="96"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="217" mass="24810" checksum="FD09ACCAEF478602" modified="2018-10-10" version="1">MFYTLFAWLFESEYKRVVQAVRASHYVDKEHFPNIVGGLLDEFTVRLANFYIRPLVAHIKKVSSEGLLQGDTPEERYIDYCRRWPKDFMDGFYTNYPLLRRVHSIIVHQFHAIAAELFERIQAQESGIRELLGAQNAEPLTLESLTMAGDYHNGGRTGCLLVFSQGTVAYKPRSVDGERAFYRIVQKLAEQGAPACVPPGSFRVKTTGSWSLLREKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXL4</accession>
    <name>A0A2Z5QXL4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">NAD(+)/NADH kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_05370</name>
        <name evidence="3" type="ORF">RA11412_0675</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86974">
        <property type="protein sequence ID" value="BAV86974"/>
        <property type="gene ID" value="RA11412_0675"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0675"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340095" evidence="1">
        <location>
            <begin position="26"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="45"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT90017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="360" mass="38407" checksum="41472764F1BDA70C" modified="2018-10-10" version="1">MSISRSKLIGASALAATTAALVARARSHAQKIVAPLGIWRTIPTGDMRRVGVVYNPSKGGASAAVGIIERTIRANGWPAPITRTTRIDEPGGEATREVLAEGADTVIAVGGDGTVRAVATALQGSQATLGIIPLGTGNLLARNLYLPVGDVASCVNIALNGVQQPVDAIRMVTDPGSDEKTEHTFFVMSGAGFDALVMNDTTEELKARIGWLAYVRTGLRHMMGHSHMVRLKMDDEPVIETRVRSVLIANCGRLQGGLQLTDMTDLDDGNLEVIVASPRTVLEWGLLTAKVMRRTLLGAPRVEMPMIRHFVGHKVELEMLDEPQPVEVDGDPAPSASHICAHIIPAAIHVNIHPDAHRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXL9</accession>
    <name>A0A2Z5QXL9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Cyclic AMP receptor-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">cAMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vfr</name>
        <name evidence="5" type="ORF">I6I94_04435</name>
        <name evidence="6" type="ORF">NCTC10207_00368</name>
        <name evidence="4" type="ORF">RA11412_0899</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888478.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87198">
        <property type="protein sequence ID" value="BAV87198"/>
        <property type="gene ID" value="RA11412_0899"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0899"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VEI22293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="225" mass="24791" checksum="EC9E647E5C4171D1" modified="2018-10-10" version="1">MDLDILRRSPLFATLDDAAFKLLTDDITEIDLSRNAVLFYEGDPGDQLYAVLSGKVKLGRTAADGRENMIAIMGPGDVFGEMALFDPSPRSTNAVAVSETRLAAIKHESFKRAQQQDPSISDQVIKTLARRLRHSNEALADLVFSDVPGRLAKALLDLADRFGRPATDGILVAHELTQEELAQLVGASRETVNKALAEFVSRGWIRLEARAVVILDLPRLRQRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXN4</accession>
    <name>A0A2Z5QXN4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87217">
        <property type="protein sequence ID" value="BAV87217"/>
        <property type="gene ID" value="RA11412_0918"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0918"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="73" mass="8278" checksum="C428BD9114C28FF7" modified="2018-10-10" version="1">MFHSPRQAGLRREKTAKSAGAMGQKNDETYLMVKKPHAPHHRGRISQENKDYRPHYGTSATATAHTMYPESVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXS0</accession>
    <name>A0A2Z5QXS0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87257">
        <property type="protein sequence ID" value="BAV87257"/>
        <property type="gene ID" value="RA11412_0958"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0958"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="247" mass="26845" checksum="2316F83E2A804B2A" modified="2018-10-10" version="1">MYEGNVNLSACTWEGAAYLSDCTYYGYTYLADSVYRGDADFWQSTFYGTANLEHCTYSRGARFEDSIYHSAAYLGDSAFRRTANLAFTVYWGAAHFGGCVFAGQAWLDNSVWFGGADFSGVKFKKKTDFEEARLLGAADFSGASFARVPAFTGGVFNAAAENVFEVSAKSKQPLPLADGVPQGARALTAAERQVLAERLQAAGAGRETNAREFEQPRSELIRWVRYEIASAPDEAEADSAGVFTEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXT2</accession>
    <name>A0A2Z5QXT2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heme ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_0837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87136">
        <property type="protein sequence ID" value="BAV87136"/>
        <property type="gene ID" value="RA11412_0837"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0837"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="105" mass="10989" checksum="130A85035731D115" modified="2018-10-10" version="1">MNVERLRMLAIAATALLTGAAVAHSGIIAFVGLIIPHLLRLLLGPSNRVLLPASALGGALLVSLSDLVARTLIPFSDMPIGIFTALVGGPTFFFLLRRSMRKGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXU8</accession>
    <name>A0A2Z5QXU8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_04100</name>
        <name evidence="2" type="ORF">RA11412_0988</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87287">
        <property type="protein sequence ID" value="BAV87287"/>
        <property type="gene ID" value="RA11412_0988"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0988"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="71" mass="7505" checksum="B346F9D7A4215E3D" modified="2018-10-10" version="1">MTRYYTSVIVFMFALPIGTLLFGGFGAGRGFAAGAAVATICAIFTYIFWPKLKDNSAPGQDSSGTSQDSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXZ7</accession>
    <name>A0A2Z5QXZ7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M20D amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87328">
        <property type="protein sequence ID" value="BAV87328"/>
        <property type="gene ID" value="RA11412_1029"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1029"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="248" mass="27095" checksum="4471BF09608C3B0E" modified="2018-10-10" version="1">MVFANSRYDLSTPVFDEWVARMMPTLTEFRRQVHRNPELSFREVKTTERIMNHLRGAGMSPVACEGTGCYVDIGNGPFALALRADIDALPIEEQTGLEYASAVPGVMHACGHDIHQTIMLGVALALHELNERTPLGRSVRILFQPAEEQLPGGAVQMIDQGLLRGVPRAFALHCDPKVDLGQIGTRIGAITSASDTIKIHLSGHGGHTSRPHLTEDLIYAMSQIAVQVPAVLTRRTDVRSGFWSPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY43</accession>
    <name>A0A2Z5QY43_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87387">
        <property type="protein sequence ID" value="BAV87387"/>
        <property type="gene ID" value="RA11412_1088"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1088"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="1">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="168" mass="18064" checksum="C8E1FAC22990ED2F" modified="2018-10-10" version="1">MHVLETQAKAPGKVNLYLAVGKPREDGYHPLATLFSSVNIYETVTARDAQEQGITLSLNIVPDSLVDQQHRAGEFDPAEVPLNEKNLAYRAAVAMVQAHRLTVNDLNLHLHIDKAVPVAGGMAGGSADAAAALLAVDQYLYEKRLTERTLGLEELLALAAPLGPMFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY77</accession>
    <name>A0A2Z5QY77_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_1103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87402">
        <property type="protein sequence ID" value="BAV87402"/>
        <property type="gene ID" value="RA11412_1103"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1103"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="21"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="380" mass="42564" checksum="E3AE51D6CC675BC2" modified="2018-10-10" version="1">MKEAYHKLRVFFPGKKFNLLILNLVGLFTVSLFEMLGVAAVLPIVNLAMGAPIEGYLKQVAELFGNPDRTALIIIFGVVLVLAFILKGAFSLIIKRWSLGFVATQQSTTSVNLLNRYMREPYLAHRKRGTANILVSVNDYAHQAYAAFVNGVINFIGELLSITVLMVMLIAIMPIPALLAFSYFGLVSYGLQHVLRKKNREQGVIVVEATRGAASATIDAVDGFREIRMHNVTDRYLYRYQTKRMDAVNASMRSTFLQDFPKYSLEIIFIIGIAGLLAFMSITSGAQSAPYLLLFCGACIRILPSYVRMVASLGNVRAGRKPAMNFCGRSLNWMNKDVNYRCHLLLWPLRTPSTLIRLLRLCASSWRTSRSATQTVIRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY85</accession>
    <name>A0A2Z5QY85_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87412">
        <property type="protein sequence ID" value="BAV87412"/>
        <property type="gene ID" value="RA11412_1113"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1113"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="152" mass="16931" checksum="4E6B25DC6C03D1F0" modified="2018-10-10" version="1">MLVWGVVAEHAALFSLGMVFFMYSHDRKFTWLMPYCAVIASINAFLMHDSAHGVGVAIICAVFFAVIYARHVPFLARGPLHALGTISYPLYLGHAMLGYMLIDMFYPWAGAWGSRIVALALVLLWAWCVHTTVETRVSAALRNVLTRKLMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYD5</accession>
    <name>A0A2Z5QYD5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="67" mass="7677" checksum="D38EB8ED937E1AF9" modified="2018-10-10" version="1">MCLELEVQDATATYNDLKTQGLDITYPLTDEPYGQRRFGFSDPSGLWVDIVEQIEPAAGYWDKYMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYI8</accession>
    <name>A0A2Z5QYI8_9MICC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87351">
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    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1052"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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            <end position="66"/>
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            <begin position="1"/>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="BAV87351.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="109" mass="11880" checksum="D4F6F697028ADD17" modified="2018-10-10" version="1">MTADAHRHHPAVEETPKISATGAPASPNLADRYGRSPRPRRTVPTRLWVALAAVVTLLAGAFVFWVQTDAAARPSARDMGFTLVSHDEASGEFELSKTRTMRPSVRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYL8</accession>
    <name>A0A2Z5QYL8_9MICC</name>
    <protein>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87381">
        <property type="protein sequence ID" value="BAV87381"/>
        <property type="gene ID" value="RA11412_1082"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1082"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="BAV87381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="64" mass="7166" checksum="009072D089D73337" modified="2018-10-10" version="1">MPEPPEQTELTQEYLDSLATLAHSTVPNEQELRASALPHGWQVEEGQTPAPYRAELYRDETGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYN0</accession>
    <name>A0A2Z5QYN0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2 3" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87575">
        <property type="protein sequence ID" value="BAV87575"/>
        <property type="gene ID" value="RA11412_1276"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1276"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="76" mass="7990" checksum="AE07D21E4DCEF77B" modified="2018-10-10" version="1">MTGLIESAIDTYSPAKNHAPADSGTFREDAAQAILWACSLAVFTGREPLAVTILGTGMRSVVLRVRYEAAGDAPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYN3</accession>
    <name>A0A2Z5QYN3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1278</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87577">
        <property type="protein sequence ID" value="BAV87577"/>
        <property type="gene ID" value="RA11412_1278"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1278"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="48" mass="5503" checksum="9747B461F3D5CF00" modified="2018-10-10" version="1">MAELPVVYKYILSVHEVEPNLLHLVFYITHNGFSVGKKLSQPHLKELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYS1</accession>
    <name>A0A2Z5QYS1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87617">
        <property type="protein sequence ID" value="BAV87617"/>
        <property type="gene ID" value="RA11412_1318"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1318"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="45"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="343" mass="36483" checksum="2FFED2A2A898EF8E" modified="2018-10-10" version="1">MPTSEPQHQQHFAAPAETRKDSHTHLPTVVPQPRNNIAALLADKAHNNDTALIVPSAAGGVTHISYRELAQAAARVQDYLQGIGVREGDRVALSLPNVPLMPAIYYGVLAAGAICVPLNPLLSAAELEHHIQDSTAKVLFAWEGTRLAEEAPRIPHIERGTLRLEILRAVTGQGPETCFAPFHMSPPDSTQAVLTPLPVCGADPALILYTSGTTGKPKGATLTHANILSNAHSCAEVFEFTNADIIFGGLPLFHAFGQTVSMNATFSAGAAVALLPRFTPTDALYLIEQAHVSVLAAVPSMYLALADVLESNPESSACLRGVSVSVYPVGHLCRNRRIGDLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ01</accession>
    <name>A0A2Z5QZ01_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin--[biotin carboxyl-carrier protein] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87474">
        <property type="protein sequence ID" value="BAV87474"/>
        <property type="gene ID" value="RA11412_1175"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1175"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="12"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="300" mass="32005" checksum="2B872A3975353FEA" modified="2018-10-10" version="1">MNQERVHNAAAQHGYRTVRVLEHTGSTNDDARQVLTDPNPSVREQLGELSVFATDDQRAGHGRLDRAWVTPPGTALAATVVVRPHAGIGQGMAPENYHWLTLIMGLSVREVLRELGVDCDLKWPNDLIAGGKKCCGVLAQLILEPAGTNPAGTAATSMSVLVGAGINLNMLEEQLPTETATSTRVLLGHTVDTEQVLTHLLEVFARRYRAFCSAGGDPESPGGGEPSLLQQAREHTLTLGAHVAMHLPDGRVITGTAEDIDDQGRILVRSDGALTAYSVGDIEHLRAADGSYLATRPPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ11</accession>
    <name>A0A2Z5QZ11_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
            <ecNumber evidence="7">6.3.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murE</name>
        <name evidence="14" type="ORF">I6I94_02495</name>
        <name evidence="13" type="ORF">RA11412_1393</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87692">
        <property type="protein sequence ID" value="BAV87692"/>
        <property type="gene ID" value="RA11412_1393"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1393"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="10">
        <location>
            <begin position="62"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="12">
        <location>
            <begin position="156"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="11">
        <location>
            <begin position="400"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="201"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="158"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV87692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT89514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="580" mass="61834" checksum="65DE7309B0662CBC" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ24</accession>
    <name>A0A2Z5QZ24_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87613">
        <property type="protein sequence ID" value="BAV87613"/>
        <property type="gene ID" value="RA11412_1314"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1314"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="42" mass="5119" checksum="E37ADA58D67851A3" modified="2018-10-10" version="1">MAEREYEHEEYDEVDGEYIEDIDGGEEVVDEDFLMRMMKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ93</accession>
    <name>A0A2Z5QZ93_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Hypothetical regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_02535</name>
        <name evidence="4" type="ORF">NCTC10207_00781</name>
        <name evidence="2" type="ORF">RA11412_1384</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888853.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87683">
        <property type="protein sequence ID" value="BAV87683"/>
        <property type="gene ID" value="RA11412_1384"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1384"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041098">
        <property type="entry name" value="Rv2175c_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18367">
        <property type="entry name" value="Rv2175c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rv2175c_C" evidence="1">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI22696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="122" mass="13424" checksum="2C72C8BB50826C50" modified="2018-10-10" version="1">MSSEKTVQTFALVGDWVTIPDIAEALDLKVTRVHNLISDGTLVALREPDTNVRKVPALFLNGDHVLESLKGTLVVLKDAGFSDEEAITWLYTADDSLPGRPIDALINGQKTEIRRRAQALAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZB8</accession>
    <name>A0A2Z5QZB8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type multidrug transport system ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87787">
        <property type="protein sequence ID" value="BAV87787"/>
        <property type="gene ID" value="RA11412_1488"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1488"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="173" mass="18298" checksum="BAA4CA9F2C242D70" modified="2018-10-10" version="1">MLPDGVHLFDRLTGEQLITYSGYLHGLDKATVAERTADLLRAMDLTEAAGRTVADYSAGMTKKIALAAALIHAPSVLILDEPFEAVDPVSAANIQDILKGFVGSGGTVVLSSHVMDLVQRLCDHVAIMNEGHILAAGTVSEVRGNTSLEERFVQLVGGRTSSEGLSWLGTSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZD0</accession>
    <name>A0A2Z5QZD0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable malate:quinone oxidoreductase</fullName>
            <ecNumber evidence="4">1.1.5.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">MQO</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Malate dehydrogenase [quinone]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">mqo</name>
        <name evidence="6" type="ORF">NCTC10207_00898</name>
        <name evidence="5" type="ORF">RA11412_1523</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">NCTC10207</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(S)-malate + a quinone = a quinol + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:46012"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MQO family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.4" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87822">
        <property type="protein sequence ID" value="BAV87822"/>
        <property type="gene ID" value="RA11412_1523"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1523"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052589">
        <property type="term" value="F:malate dehydrogenase (menaquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008924">
        <property type="term" value="F:malate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00212">
        <property type="entry name" value="MQO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006231">
        <property type="entry name" value="MQO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06039">
        <property type="entry name" value="Mqo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01320">
        <property type="entry name" value="mal_quin_oxido"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VEI22812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <sequence length="522" mass="56942" checksum="7180B07770327013" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZG5</accession>
    <name>A0A2Z5QZG5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87614">
        <property type="protein sequence ID" value="BAV87614"/>
        <property type="gene ID" value="RA11412_1315"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1315"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="209" mass="22826" checksum="9D2983ACE4416A15" modified="2018-10-10" version="1">MHGDEEYEEYSENRASVSWGAVLSVVAALILAVALCVVGGRALFAAQQDTGITGKTWVIEGSFVDVTPDLETKDNVARYKGTLPVDERIDGKTYRSNLKDRQKVSRGEEIEFRGSQTGMVSSDFPREVSALLVETGDNQLEVIRTGEKGSLHEVDEGTVGRQKLIGWASFIGALLVLIGGGYVGVILTRRARQQALESEYEGEEDLELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZL0</accession>
    <name>A0A2Z5QZL0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein DnaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87654">
        <property type="protein sequence ID" value="BAV87654"/>
        <property type="gene ID" value="RA11412_1355"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1355"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="79" mass="8260" checksum="261B6E8E7311AC48" modified="2018-10-10" version="1">MSAIVLKRLKEDAELALGASVTDAVITVPAYFDDSRRIATKHAGQIAGLNVLRVLNEPTAAALSYGVENNSGGMCLSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZQ1</accession>
    <name>A0A2Z5QZQ1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpH</name>
        <name evidence="8" type="ORF">I6I94_02175</name>
        <name evidence="7" type="ORF">RA11412_1472</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87771">
        <property type="protein sequence ID" value="BAV87771"/>
        <property type="gene ID" value="RA11412_1472"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1472"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="270" mass="28681" checksum="EA84EF7892039E66" modified="2018-10-10" version="1">MAGVSTESLSKVEAALDANASLNPLHLASELFAVVDVIDRDGGLRRGLTDTSRVEAARQNIASTVFGSKVSSQTLSVLTVAVSQRWSAERDLADALEKCAVLAAIVSTHSHGGVEALDTLINELLTFVRNVDGTAQAQTALSNNLASKEAKQKLAVALGGPARSAEGVLLLERIGSETRGMHAARLADEFVEIIVKRQNRYIAKVTSAVALSQAQLNRLGHALSRVYNRKLKLDISVDPTVLGGLRVQVGDEVIDGTVIARLDELERNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZR0</accession>
    <name>A0A2Z5QZR0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Hydroxymethylpyrimidine phosphate kinase ThiD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_01280</name>
        <name evidence="8" type="ORF">RA11412_1686</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87985">
        <property type="protein sequence ID" value="BAV87985"/>
        <property type="gene ID" value="RA11412_1686"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1686"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="7">
        <location>
            <begin position="18"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="TENA_THI-4" evidence="6">
        <location>
            <begin position="340"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="547" mass="58484" checksum="ECED91115CE80E09" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZT9</accession>
    <name>A0A2Z5QZT9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_02370</name>
        <name evidence="1" type="ORF">RA11412_1425</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87724">
        <property type="protein sequence ID" value="BAV87724"/>
        <property type="gene ID" value="RA11412_1425"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1425"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="148" mass="17562" checksum="C3653D02EBF74A1F" modified="2018-10-10" version="1">MADEQRILDIIDGLEGNFTEQEAYRIYIEFCFRFIPRIEHKIPEKLRAHLEAAEGYWHAGNVSPQALENARVLIWKYLDSHNLTYAPLRKSAAIRFMHQLFWDKANTDIWDHFDWCRELLPHLGYKNHTILQELEYVLSEATREGFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R004</accession>
    <name>A0A2Z5R004_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87871">
        <property type="protein sequence ID" value="BAV87871"/>
        <property type="gene ID" value="RA11412_1572"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1572"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010179">
        <property type="entry name" value="CRISPR-assoc_prot_Cse3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08798">
        <property type="entry name" value="CRISPR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="48" mass="5341" checksum="DF0215C00963737F" modified="2018-10-10" version="1">MTYFSKFLINPQRRGARKLLSSPQALHAAVMATNPPDIKTKMGAYYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R035</accession>
    <name>A0A2Z5R035_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3099 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00985</name>
        <name evidence="2" type="ORF">RA11412_1779</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_052029820.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88078">
        <property type="protein sequence ID" value="BAV88078"/>
        <property type="gene ID" value="RA11412_1779"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1779"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021449">
        <property type="entry name" value="DUF3099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11298">
        <property type="entry name" value="DUF3099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="147" mass="16259" checksum="80393C4854C241C7" modified="2018-10-10" version="1">MSEKYWTAEDLADHGYRLEQAPEDQAEQDDAYCITGADEPLSQRVNKRSREYIFKMSLRVVCIVCAVLVDGWMRWAFVAGSAVLPWAAVVIANGEAKNRNSGFVPYKHNVPQLALTASMQGQDSGKPSYNTSEVIDLQAHPAGPDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R044</accession>
    <name>A0A2Z5R044_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88135">
        <property type="protein sequence ID" value="BAV88135"/>
        <property type="gene ID" value="RA11412_1836"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1836"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="2">
        <location>
            <begin position="146"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="331" mass="37407" checksum="2747CA697A1155DE" modified="2018-10-10" version="1">MVGMEELFRVYHLLACSPRYGISRTEFLGALGIRVGRDDALSPSQEQEFERAKKALRDAGIPLVNTETGGYRLQVGPNPLTGWDMTVEDYRVLDTLCKGWYGTDLEDSARRILRKVAASVPNLQHVKKLHSHAEPLTRIRFQDDPYLEEIFSALAEHKNVSVSYQNYSGARRQSTLSVWGVGHRYGNWYFVGFDSSKAQPRAQQQGFTYRLSRMGSLTVLKTGPKAFTAAPVQFSMADSLDRLGRWQNSTLTVEDARTGQQFTVPSYGTVETATDAISNGWRIPHAEDNEHQRTVRQVQQRILRELQQAHEHPAKTPSGWKKTQPAIGLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R052</accession>
    <name>A0A2Z5R052_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical ATP-binding protein UPF0042</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88003">
        <property type="protein sequence ID" value="BAV88003"/>
        <property type="gene ID" value="RA11412_1704"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1704"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="123" mass="13736" checksum="D51BCFC9FF83E3B8" modified="2018-10-10" version="1">MSVELQEQKPQILVITGISGAGRSTVANVLEDEGWYVIDNIPPQMLESLAELVTRDGARVPRVALGIDVRARALFDDLPAAIDTLRKSDVDFSMLFWMLKTRRLWPGMRRSAARTRCRGGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R072</accession>
    <name>A0A2Z5R072_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88117">
        <property type="protein sequence ID" value="BAV88117"/>
        <property type="gene ID" value="RA11412_1818"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1818"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="152" mass="16077" checksum="D974D88324BB5135" modified="2018-10-10" version="1">MPLSAVTGRAELFEKVQPGGLGGTYGGNPVSCAAALAAIETMQEWDLNARALRIEEIVTAKLTPLVEELDIVGDFRGRGAMLALEFVADSISKAPHPTAAKDVAAYCRDRGVLILTCGTYGNVVRLLPPLAMPDELLEQAMDILVAGIRDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R088</accession>
    <name>A0A2Z5R088_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87884">
        <property type="protein sequence ID" value="BAV87884"/>
        <property type="gene ID" value="RA11412_1585"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1585"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="38" mass="3981" checksum="DE2FABC61A74CDF2" modified="2018-10-10" version="1">MPSAPPGSSPRMRGTRDYTGKFPGAIGLIPTYAGNTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0G2</accession>
    <name>A0A2Z5R0G2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87964">
        <property type="protein sequence ID" value="BAV87964"/>
        <property type="gene ID" value="RA11412_1665"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1665"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="2">
        <location>
            <begin position="5"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="395" mass="43416" checksum="CE4F261366DD228A" modified="2018-10-10" version="1">MSTSDKTLLLIDGHSLALRSFFGIYTMAEKTGQHVFVRSDGQHTEAVHAFLSTLLNIIKDYRPSHIAVAFDLPGGTFRTAEYSDYKGGRTEIPQAFDGQIDLIKKMLTALRIPALTQENYEADDIVATLTRRGTEENYRVFILSGDRDIFQLVTDKVTLLYPVTTGPSKGIQLMDPAAVEKKTKVPPRLYPDLAALTGEQADNLPGVPGVGPGFAAKWLTEYGDLDGVIANQDSIKGKKGEALRENIENVRRNRRLNQLVDDLNIPLDLGEDTRFLPDLDALDSFFDEVQFRTIRKRAHDTLGPVVRAAGAATRTAAATAGVVRLMNSGRGRSLPCRGSNPPPRKRYLLGLSLSLSQRINRSPRKPPRSFAIGAPRLLPKATVKALMCLNVLKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0J5</accession>
    <name>A0A2Z5R0J5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4870 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00305</name>
        <name evidence="4" type="ORF">NCTC10207_01242</name>
        <name evidence="2" type="ORF">RA11412_1949</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887297.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88248">
        <property type="protein sequence ID" value="BAV88248"/>
        <property type="gene ID" value="RA11412_1949"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1949"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI23145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="129" mass="13992" checksum="16843C4B34B4F8FE" modified="2018-10-10" version="1">MTHNTQSASSELSEAKERTIASFAHFGGILGFLPSAAIYLKYRGRGTGFAEQEAREAMDFTLVPSIVILVFMVASLIPNIGNVALPAAALAWIFMAIGAMLGGSKASKGYAYTYRFTPRLLEKSYFDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0M5</accession>
    <name>A0A2Z5R0M5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88193">
        <property type="protein sequence ID" value="BAV88193"/>
        <property type="gene ID" value="RA11412_1894"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1894"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009293">
        <property type="entry name" value="UPF0478"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06103">
        <property type="entry name" value="DUF948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="135" mass="14098" checksum="653BEA7A58D58F0A" modified="2018-10-10" version="1">MTGGDIAGLIAAGVFAILVALLAVPILRLTKVFDELIVTIRSLNQSTNPLIEEVTKTVVSTNEQLEKMDDITSNVSDASANVSALSSLVTSTVGQPLIKVASFSYGVRQAFRGGSTNAQNPKTPGPEKPQQGGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0T1</accession>
    <name>A0A2Z5R0T1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_2096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88395">
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        <property type="gene ID" value="RA11412_2096"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
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        <location>
            <begin position="35"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="720"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="782"/>
            <end position="845"/>
        </location>
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    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="847"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="567"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
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            <dbReference type="PROSITE" id="PS51272"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
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    <sequence length="902" mass="95895" checksum="03C00668F9A7C2CF" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0X2</accession>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">JCM 11412</strain>
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    </evidence>
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        <source>
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</entry>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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            <end position="30"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="50" mass="5151" checksum="39C9552C400679F7" modified="2018-10-10" version="1">MTRVSLNSAYHSVASSAVGTRSSRHGGSGAKRRIVAAGEFEQVGGGEFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R173</accession>
    <name>A0A2Z5R173_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_00285</name>
        <name evidence="8" type="ORF">RA11412_1957</name>
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        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88256">
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        <property type="gene ID" value="RA11412_1957"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1957"/>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
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    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="342" mass="37675" checksum="D40B48341BD0E779" modified="2018-10-10" version="1">MCGRYGLEAHYGTSLGGVQLTEPFTSWNIAPTQQVPILLNRRVPRTAQGQLLDAPRRPGVHRLGASTLDTGGTYREIYRARWGLIPDWHPWDEDPKPPSLTFNARSETLFEKTSYARPAVTGHCAIPTSGYYEWGVQGSTVTARGTVKEHKIPQRIGPPGQYLYLAGLYAWHKINPVSAKALTGGGYEPQTGQWLLTFTILTMASPRSYTRQDGSPLLRELGHIHERMPLPLNPAAVNGQPSTLDVWLGSGRVAGTPEDSRMPTMGVSDLHDARTALEQLQHAAYPQAAQWRVRQVSSRIGNIKNNDKSVLEPDTNLLTLLDSDTYAEHTTNPEGTHALGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R189</accession>
    <name>A0A2Z5R189_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zeta_toxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88261">
        <property type="protein sequence ID" value="BAV88261"/>
        <property type="gene ID" value="RA11412_1962"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1962"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010488">
        <property type="entry name" value="Zeta_toxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06414">
        <property type="entry name" value="Zeta_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zeta_toxin" evidence="3">
        <location>
            <begin position="40"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="185" mass="20995" checksum="F03CB9D73EE663AC" modified="2018-10-10" version="1">MIDPELLDRAFLRQYLAEGWYEALKPEPAREFEKQGNKLFPMDIATIAREDSAKLGSILLSTFADEGMNLILEATFTPGFVAQQLVDYLSRNGYSINAVRLTIEKEQAVERCEARYEREYEQALTQGLDALGAKPVDTAYIDYVLRTTLRLRKLRKRLLASRVWALKTVVAGTFEGARYSCAMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1B6</accession>
    <name>A0A2Z5R1B6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88462">
        <property type="protein sequence ID" value="BAV88462"/>
        <property type="gene ID" value="RA11412_2163"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2163"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="142" mass="15542" checksum="2C70D2F79899A3D7" modified="2018-10-10" version="1">MNAKDYPEDFPDKLDYALHTLSPTQHAAFESWASKQEREDAEADAAALSEVFGTSLTPLEPSVELKARVMAQVAHTEQLQPAHEIGTDDELTEHTNDSAENQSSSASDPADDIETTAGPEDSAYARAKRWWFGAQGHSLRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1S7</accession>
    <name>A0A2Z5R1S7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88520">
        <property type="protein sequence ID" value="BAV88520"/>
        <property type="gene ID" value="RA11412_2221"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2221"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015315">
        <property type="entry name" value="DUF1963"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035948">
        <property type="entry name" value="YwqG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09234">
        <property type="entry name" value="DUF1963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103032">
        <property type="entry name" value="SSF103032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="270" mass="30519" checksum="A6D89843A8F7351C" modified="2018-10-10" version="1">MVNYQRDKVPITVRAADAPLPVTASKYGGVPYLPAGVDAPLGSDGQPLGMIAQINCAELPKNTIYPESGMLQFWLNPRHPQWGMNINDGLPGADARVIYWKELGAANPHACAVEANWEEHYWPIDPPTREISLIFGPPETPDPMLTWGDHEQFIEIWNELYPDQAIEEIEELEDLVEEAEEDEDILSAIADEAGYHQLGGYPVFFDDDPRRNNPELEEYTVNLLTMGSESYRLGSTELLWGDAGYANWLITPEQLAARDFSKVLFWWWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1U8</accession>
    <name>A0A2Z5R1U8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome d ubiquinol oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cydB</name>
        <name evidence="9" type="ORF">I6I94_10610</name>
        <name evidence="8" type="ORF">RA11412_2215</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88514">
        <property type="protein sequence ID" value="BAV88514"/>
        <property type="gene ID" value="RA11412_2215"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2215"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000267">
        <property type="entry name" value="Cyt_oxidse_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="360" mass="39112" checksum="A9FC329762281FBA" modified="2018-10-10" version="1">MNFDFNIFAGQPTLPTIWFVVVGVFWIGYLILDSFDLGVGMLMSRFFAKSEQERRLLLNTIGPVWDGNEVWVVTGGAATFAAFPLWYASLFSALYVPLTLALLALIFRAVAIEYRGKKNDERWINGWNTAISVSSFFIALLMGALLALTSIGLPINSNGDRVGGAFAWASWPVLLGGLSLVGFSLMQGLAFVALKTDGEIRHRARAALVRLLPIALLPITGWVLYMQFTTGNGVSWLCTILAVVAVALGWLSAKAGREGRAFAGLSLFIAFGALAIFTALYPNVLPSTLDASHSLTIANASSSEYTLGVMSVVGLMGLPVILVYQGWTYWVFRKRLRVEHIPAAHDATDLTKLPNKVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1V5</accession>
    <name>A0A2Z5R1V5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88673">
        <property type="protein sequence ID" value="BAV88673"/>
        <property type="gene ID" value="RA11412_2374"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2374"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="51" mass="5850" checksum="4B5FD04CF8590930" modified="2018-10-10" version="1">MSEQNHLRTEENPRIDKARILKDRLEKNTPKGMPRAAKAGGRRPVRVPSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R258</accession>
    <name>A0A2Z5R258_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.117</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Tetrahydrodipicolinate N-succinyltransferase</fullName>
            <shortName evidence="4">THDP succinyltransferase</shortName>
            <shortName evidence="4">THP succinyltransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Tetrahydropicolinate succinylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dapD</name>
        <name evidence="6" type="ORF">RA11412_2383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA</text>
            <dbReference type="Rhea" id="RHEA:17325"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15685"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="2.3.1.117"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.117" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88682">
        <property type="protein sequence ID" value="BAV88682"/>
        <property type="gene ID" value="RA11412_2383"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2383"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008666">
        <property type="term" value="F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02122">
        <property type="entry name" value="DapD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019875">
        <property type="entry name" value="DapD_actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032784">
        <property type="entry name" value="THDPS_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038361">
        <property type="entry name" value="THDPS_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026586">
        <property type="entry name" value="Type2_DapD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14789">
        <property type="entry name" value="THDPS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03535">
        <property type="entry name" value="DapD_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THDPS_M" evidence="5">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Succinyl-CoA binding" evidence="4">
        <location>
            <begin position="257"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Succinyl-CoA binding" evidence="4">
        <location>
            <begin position="294"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-anhydride intermediate" evidence="4">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="321" mass="33531" checksum="DE31F1A21F6761EC" modified="2018-10-10" version="1">MSENASTETRYASGVALVNVVASGPDAGTVLDAWFPAPALTQTPDLSLADELEELTGEHPERNARTEVRTVSIDLDEAPEDAVDGYLRLHLLSHTLVRPNDLNLEGLFGHLANVAWTNHGPVLATELNKLALGLRKLGHLSVSHVDKFPRLIDYVVPAGVRVGDGDRLRLGAHLADGTTVMHEGFVNFNAGTLGTSMVEGRISQGVVVGDGSDVGGGASTMGTLSGGGTQRVSIGERSLLGAESGIGIALGDDCVVEAGLYVTAGSRVIVLIPGEDVRVVKAAELSGVSNLLFRRNSVTGAVEVLPRAKNSVELNEALHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R259</accession>
    <name>A0A2Z5R259_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_2509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88808">
        <property type="protein sequence ID" value="BAV88808"/>
        <property type="gene ID" value="RA11412_2509"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2509"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="206"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="384" mass="40121" checksum="295436D9EB016686" modified="2018-10-10" version="1">MNEGVREGVGYLQQRMSQCPNSQYVLGGYSQGAQVMGDVYRQLTDEQRSKVAFNAFFGDPKMNLPEGRSVAGEHPVFDGRGISPWRRQSPAPATTQGSLGARTPYLPAGEQNTGSWCLANDYVCGSTKVLMGFSRENGHILYAQANGPIDEALREAFSRVGQRRGVEDAAARLTPAGSGPVVNLPADEYYAPVGHTVRLDAGASYSAGSKIVRWDWDIDGDGVYETHDGAAVMEHSYSVQGDYTVKVRATDNNGAVTERQVTVHAGTTTGIPTLPEAAATVSGERNGTEATLRWSAAKAPELGWQITVNGFPVGVYTSNTAEAVVTGLDASRDVQIGVAPVSAQGIAGEVKTFTFKAQGGSTPGGSAPGGSSVPGGSVSAEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R263</accession>
    <name>A0A2Z5R263_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MurR/RpiR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Uncharacterized HTH-type transcriptional regulator ybbH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ybbH</name>
        <name evidence="5" type="ORF">I6I94_09480</name>
        <name evidence="6" type="ORF">NCTC10207_01697</name>
        <name evidence="4" type="ORF">RA11412_2484</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88783">
        <property type="protein sequence ID" value="BAV88783"/>
        <property type="gene ID" value="RA11412_2484"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2484"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="107"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VEI23733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="274" mass="31094" checksum="FA3235DD0EBE0265" modified="2018-10-10" version="1">MDLQDVVNANQHRFSGTEREILAFMLDNEKFVAEATISSLAHKTYTSTSSIIRLTKKLNFSGFAELKYFIKSSLTRSEPYNPRFIESGKEDILRTYDYLEHMELSKLLEKMHDARTIYCFGTGYAQRNAVQEFAKSMQVCGKFCHVIPARNEFESTMTSMTTNDLVILVSFSGQTENMREHVKMLALRKIPMVAVTALGVNYMSSHAEYSLHYQSTPTQITGQRGPYNSFVALSVLLDYLVRRYIDHIETRNPQRQPGGNETDPGTGPAEPTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R269</accession>
    <name>A0A2Z5R269_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">typA</name>
        <name evidence="2" type="synonym">bipA</name>
        <name evidence="5" type="ORF">I6I94_09870</name>
        <name evidence="4" type="ORF">RA11412_2393</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887470.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88692">
        <property type="protein sequence ID" value="BAV88692"/>
        <property type="gene ID" value="RA11412_2393"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2393"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="9"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="21"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="636" mass="69432" checksum="350069DCCB1582ED" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R293</accession>
    <name>A0A2Z5R293_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">tuf</name>
        <name evidence="11" type="ORF">I6I94_09075</name>
        <name evidence="12" type="ORF">NCTC10207_01786</name>
        <name evidence="10" type="ORF">RA11412_2576</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887686.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88875">
        <property type="protein sequence ID" value="BAV88875"/>
        <property type="gene ID" value="RA11412_2576"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2576"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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            <end position="50"/>
        </location>
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        <location>
            <begin position="26"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAV88684.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
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    </evidence>
    <sequence length="50" mass="5596" checksum="3D093953E37A1DBB" modified="2018-10-10" version="1">MCDLPAGFLRKKNHRTCAPPLTRPTAFTKSPENTGFTEYLTPNTPHNPLL</sequence>
</entry>
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    <accession>A0A2Z5R2C9</accession>
    <name>A0A2Z5R2C9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">50S ribosomal protein L10</fullName>
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    </protein>
    <gene>
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    <reference evidence="9 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887692.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88915">
        <property type="protein sequence ID" value="BAV88915"/>
        <property type="gene ID" value="RA11412_2616"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2616"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT88633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VEI23952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="175" mass="18428" checksum="B247050A9D321B93" modified="2018-10-10" version="1">MATQEKIAAVSELKELFEASNAVILTEYRGLTVTQLKELRRALGAETEYAVVKNTLAAIAAKEVGIDAFDGQLHGPSALAFIKGDLIDAAKGLRDFAKANPQLIVKSGFYEGAALTEADVKRYADLESREVLLSKVAGGAKAAIARVAQAVDALRVKLEEQEGGAPAAEEAADEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2F5</accession>
    <name>A0A2Z5R2F5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Coproporphyrinogen III oxidase</fullName>
            <ecNumber evidence="6 12">1.3.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">hemG</name>
        <name evidence="15" type="ORF">I6I94_09995</name>
        <name evidence="14" type="ORF">RA11412_2357</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:43436"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="1.3.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:43437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.15" evidence="6 12"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88656">
        <property type="protein sequence ID" value="BAV88656"/>
        <property type="gene ID" value="RA11412_2357"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2357"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0274">FAD</keyword>
    <keyword evidence="8 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV88656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QQT88842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="499" mass="52436" checksum="B1AA11FBF82C5489" modified="2018-10-10" version="1">MGLHRAAHPHIGKNAPTAIVVGGGVSGLLAARELAAAGVRVTLLEQKDHLGGAVGAHEVGGLLLDSGAESYATRSPIVSELVKELGLGEHIVTPNPHGSWLYLPFGARKTPNTGIMGIPGNLDDKTLLGVLGRAGLRRAKLDKTLPASVGAKAKTLGELVRARMGNKVLKNLVAPVVSGVYSAHPDQLDADATIPGLREGLKKHKSLAAASAALRSQAPAGSQVASLSGGLNQLSEKLVEDLYTKCARIIAGFDVIAIDRDSVTGEWFVIQRHTVDGEIQATLRADYLVLATDGPTTARLLGSHIKTSLPTLEPGPEVALVTLVVEQPALNAHPRGTGMLVSEEVTNVRAKALTHVSAKWPWVAEAVGKDKHVVRLSYGRGGENASISDVALADEQLITLALHDAAKLLDVPITAHELLDADVVRWSNVLPRTAPGHRDKVKTFRELTAQLETVCVVGTWAAGSGLVSTVRDTREQVEQFLKRNTPQADGAKSGEEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2G8</accession>
    <name>A0A2Z5R2G8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1697 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_08760</name>
        <name evidence="1" type="ORF">RA11412_2656</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88955">
        <property type="protein sequence ID" value="BAV88955"/>
        <property type="gene ID" value="RA11412_2656"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2656"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012545">
        <property type="entry name" value="DUF1697"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36439">
        <property type="entry name" value="PTHR36439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08002">
        <property type="entry name" value="DUF1697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008502">
        <property type="entry name" value="UCP008502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="178" mass="20398" checksum="4DD25B97D6DB4644" modified="2018-10-10" version="1">MQYILLLRSVNLGKLRKVSMPELKKRLAALGYENVTSYINSGNLLFVSSRDKTTVAQEITELLAEHYDFEIPFSLLTADEYRKDAHNLPEWWNEDMPRLDAMFFTIDADRDALAAELETLDVPDEVLHVGTCAVYFGNYSTPDYKKAQYGKFMSKKAFANQLTLRNAKTCNKILDLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2L4</accession>
    <name>A0A2Z5R2L4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89007">
        <property type="protein sequence ID" value="BAV89007"/>
        <property type="gene ID" value="RA11412_2708"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2708"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="39" mass="4319" checksum="5E2AFCBBC0CA044A" modified="2018-10-10" version="1">MTEPGVVRGRLGYAEGANVHRINRIGLENGLTKFTSFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2P2</accession>
    <name>A0A2Z5R2P2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase DeaD</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cold-shock DEAD box protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">deaD</name>
        <name evidence="5" type="synonym">csdA</name>
        <name evidence="13" type="ORF">I6I94_08710</name>
        <name evidence="12" type="ORF">RA11412_2664</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88963">
        <property type="protein sequence ID" value="BAV88963"/>
        <property type="gene ID" value="RA11412_2664"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2664"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070417">
        <property type="term" value="P:cellular response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00964">
        <property type="entry name" value="DEAD_helicase_DeaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028618">
        <property type="entry name" value="DEAD_helicase_DeaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="11">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="129"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="330"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="639"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="659"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV88963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT90146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="699" mass="76730" checksum="1F5E5A6B9FD716C7" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Y4</accession>
    <name>A0A2Z5R2Y4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">moaA</name>
        <name evidence="15" type="ORF">I6I94_08960</name>
        <name evidence="14" type="ORF">RA11412_2605</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
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                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="QQT88502.1"/>
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    </evidence>
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    <sequence length="288" mass="32077" checksum="E9066A496E9929E8" modified="2018-10-10" version="1">MLHLDENARLNGEPVRYVALGDSFTEGVGDIDESRPNQVRGWADRVADAIGARDAQAQYANLAIRGYLMDQIMDEQLAPALELKPNLVSIYGGGNDIIRPKVDIDALVQRMDDAFALLRAEGIEVFTMTGLDFLGEGPFARTRPRTALYNELIREVAENRGVHIVDYWRMRDFVDWRLWAPDKLHMNEYGHQKFAARVLSLLGLEGAVPEPQLPPVVELSRREELEQSARWVWEHALPWVGRRIRGTSSGDGLQPKYAAFRPALFEPSARALGSGVGVPAGKHVVSAA</sequence>
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    <accession>A0A2Z5R3V2</accession>
    <name>A0A2Z5R3V2_9MICC</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88029">
        <property type="protein sequence ID" value="BAV88029"/>
        <property type="gene ID" value="RA11412_1730"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1730"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="261" mass="29626" checksum="C6920D0AD7A22BA4" modified="2018-10-10" version="1">MTAAASTLAQRRATLKKLMADPKATFDQYRGIINGATEKERASLARTLNAEKAAASDLPKSIKAYLAAALTAKPARAAQQLHQLTHLTEAGRIGQRREIRDHFMWGTEERRDEWVLEFADQYASTRASLYGQWELSNTILRNRGLSCSTPRYLAMFLANIPPVYDDSPKNHAETTQFFRTNPHCLEQQFWDVFTVEGALRQHPSTWAPRTRRGEPSFGALTRLLSEEFEGVRPRCLTETLQALLRDFGPADSRYFIQHTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R443</accession>
    <name>A0A2Z5R443_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonucleotide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88279">
        <property type="protein sequence ID" value="BAV88279"/>
        <property type="gene ID" value="RA11412_1980"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1980"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="2">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="422" mass="48178" checksum="ABACECC40B8C7A9A" modified="2018-10-10" version="1">MIPDITFKLAKENKDMYLFSPYDVERIYGVPFSDINVSEKYQEMVDDSRIRKTKINAREFFQTIAEVQFESGYPYIMFEDTVNRANPIDGKVIMSNLCSEILQVSKPSKYHDDLGYAETGKDISCNLGSLNIAMTMDGDNLGKTVETAIRSLTSVSDQSDIRSVPSIERGNDMSHAVGLGQMNLHGYLAREHVHYGSEEALDFTNIYFYTVAYHAIRASMEIAKERGVTFEGFENSKYASGEFFAKYIEKEWEPQTERVRELFAKHHIPTREDWIQLAADVAQYGMYNQNLQAVPPTGSISYINGSTSSIHPIASKIEIRKEGKLGRVYYPAPFMTNENLDYYKDAYEIGFEKIIDTYAVATQHVDQGLSLTLFFRDTATTRDINRAQIYAWRKGIKTIYYIRLRQMALEGTEVEGCVSCML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R478</accession>
    <name>A0A2Z5R478_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">RA11412_2060</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88359">
        <property type="protein sequence ID" value="BAV88359"/>
        <property type="gene ID" value="RA11412_2060"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2060"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="15">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAV88359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="111" mass="12679" checksum="5862BED1641D7ACE" modified="2018-10-10" version="1">MAMIEATARLIPGVIGNPESLTEESHTGGLLEYPVFTKPASWRGFQVPPVLLSGNHGAVARWRRERQIERTMARRPDLFAAYPTQQWDKKDRRFLAERGVHFPKPNTQDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R497</accession>
    <name>A0A2Z5R497_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6318 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88409">
        <property type="protein sequence ID" value="BAV88409"/>
        <property type="gene ID" value="RA11412_2110"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2110"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046281">
        <property type="entry name" value="DUF6318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19843">
        <property type="entry name" value="DUF6318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6318" evidence="1">
        <location>
            <begin position="27"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="205" mass="22811" checksum="EB221C4A39AF14BD" modified="2018-10-10" version="1">MDSASGSQVRGPVVLPAQYYETANGPFEAGTLEHGPQNVAKPKEPENMRELSEQGILSFLQYWCAAQNYMYLTGDISLFEALPGNDKYSTNIGIYSKLYSRDEGWVVCDTERPTGITLNTDRPVRIGSSEVFRWESMYTVDNKAHLYLLKAQRNVSFTDMYGTTRRADVFVKYGDNGWQMMDDAEVSAAKESLAPSASAASPSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4C0</accession>
    <name>A0A2Z5R4C0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">msrB</name>
        <name evidence="6" type="ORF">I6I94_10750</name>
        <name evidence="7" type="ORF">NCTC10207_01425</name>
        <name evidence="5" type="ORF">RA11412_2170</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88469">
        <property type="protein sequence ID" value="BAV88469"/>
        <property type="gene ID" value="RA11412_2170"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2170"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VEI23318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="141" mass="15775" checksum="7D089E05FA503410" modified="2018-10-10" version="1">MGNSLPGTGKIEKNWREILTPEEYAVLREGGTERAFTGEYWDTKTEGVYSCRACGTELFRSAEKFESHCGWPSFFAPLAEERVRYLEDTTFGMRRVEVRCAACDSHLGHVFEGEGYGTPTDLRYCINSVCLSLEPAAGNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4L8</accession>
    <name>A0A2Z5R4L8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamyl-tRNA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88659">
        <property type="protein sequence ID" value="BAV88659"/>
        <property type="gene ID" value="RA11412_2360"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2360"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="1">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="68" mass="7249" checksum="D4D30539CEEB64FC" modified="2018-10-10" version="1">MTIYAFVASHRIIDLTTVALLSNGASGVPETLKSDTAQQLGVEGSVVLATCNRLEVYIKLTVPKHLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVI3</accession>
    <name>A0A2Z5QVI3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86392">
        <property type="protein sequence ID" value="BAV86392"/>
        <property type="gene ID" value="RA11412_0093"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0093"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="242" mass="24678" checksum="C2DCD1E98D76906E" modified="2018-10-10" version="1">MAPAAYAAPEPSATPIVKEYTDGATLTFPSTWTEGEPLEFSGVNFFATNGTPSVLAVRLNGGPVGSSDYLQFEADADGKVSGSIPWQDRYTAGSTATINVLTGSLNPNDNKRGGIAASVTVVDKNGGTGKAKPSESASADANKSESPKEDPSKGAKTETPAKEESSPAAKEEETHTAASSATTDADEKPLSPISSSASPTAVTSASSNNSGGNMMPWLGYGLIGGGVVLAALIIFFNIRRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVK8</accession>
    <name>A0A2Z5QVK8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonuclease HI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86428">
        <property type="protein sequence ID" value="BAV86428"/>
        <property type="gene ID" value="RA11412_0129"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0129"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="40" mass="4535" checksum="3916B53348A2E925" modified="2018-10-10" version="1">MEQAQQAREGFNALKLNGVLKPASAVAAPTRRRWRSVRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVM0</accession>
    <name>A0A2Z5QVM0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonuclease HI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86430">
        <property type="protein sequence ID" value="BAV86430"/>
        <property type="gene ID" value="RA11412_0131"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0131"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="4457" checksum="7BAACE5BAEACE9F7" modified="2018-10-10" version="1">MSEIIAAADGSALGNPGPAGWAWYIDDNHWAAGAGSTAPTIWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVM6</accession>
    <name>A0A2Z5QVM6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphopantetheinyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86431">
        <property type="protein sequence ID" value="BAV86431"/>
        <property type="gene ID" value="RA11412_0132"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0132"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="102" mass="10823" checksum="BAA70C1BECD569FE" modified="2018-10-10" version="1">MITTVSTSGGAQVAVFALPTRTMYSGLRVSWLSYLGAAEQRRAAELPTPVGAVSYLSTQALMRSMAACRLGLPPARRTRSKWIVPAPYATAPSRTANPALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVP4</accession>
    <name>A0A2Z5QVP4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Fructose-specific IIA component protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="18">PTS sugar transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I6I94_07540</name>
        <name evidence="17" type="ORF">RA11412_0164</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86463">
        <property type="protein sequence ID" value="BAV86463"/>
        <property type="gene ID" value="RA11412_0164"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0164"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
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    <name>A0A2Z5QVZ9_9MICC</name>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="BAV86578">
        <property type="protein sequence ID" value="BAV86578"/>
        <property type="gene ID" value="RA11412_0279"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="32"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="175" mass="19608" checksum="C80687A31B0F9F8D" modified="2018-10-10" version="1">MSSARSRSNRPDAVDIIIDQWKRELPELASENMALIGRLKRCSILLAPRLDEVFAAHDLSNGAFDVLATLRRAGAPYILTPTELFASLMVTSGTMTTRLQKVQKRGFIERIPNPDDARSMLVKLTGAGRELVEKVVFEHVDNERRILEKLPAETRRQLDAGLAELMRVLEDAKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW46</accession>
    <name>A0A2Z5QW46_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0312"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="40" mass="4270" checksum="968233F55CE9E670" modified="2018-10-10" version="1">MGVCREPARVCFGVAPSYLTVALNRLPRRIGVPLLGSAKT</sequence>
</entry>
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    <name>A0A2Z5QW76_9MICC</name>
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        <lineage>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0366"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="123" mass="13699" checksum="A23AD8D255BDDC75" modified="2018-10-10" version="1">MMAGAPGAGKSTTLKRALDGSPDTYLPIDPDAFKVLLIEEAIKSGEINTFYNIPEVKQLTDQGEKFFPMDFGSLVHQESTYLAEELLKDAQREDKTLFLTGSTVTPAPFNETLTGYRKRLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW85</accession>
    <name>A0A2Z5QW85_9MICC</name>
    <protein>
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        </submittedName>
        <submittedName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06690</name>
        <name evidence="2" type="ORF">RA11412_0347</name>
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    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 4" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037233855.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86646">
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        <property type="gene ID" value="RA11412_0347"/>
    </dbReference>
    <dbReference type="GeneID" id="32322270"/>
    <dbReference type="KEGG" id="raj:RA11412_0347"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86646.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="527" mass="56979" checksum="A6A1BC49DC1C8321" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
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    <name>A0A2Z5QW92_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin PHD</fullName>
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        <name evidence="3" type="ORF">NCTC10207_02292</name>
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    <reference evidence="1 4" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="component" value="Chromosome 1"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="41" mass="4783" checksum="ED3BED5B25D4B479" modified="2018-10-10" version="1">MTGLDPVEEYEELLDIEALRKARAEDDGYRISLEDFLQQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWA2</accession>
    <name>A0A2Z5QWA2_9MICC</name>
    <protein>
        <submittedName>
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        <submittedName>
            <fullName evidence="4">Transcriptional regulator TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_06495</name>
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    <organism evidence="4 6">
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86695">
        <property type="protein sequence ID" value="BAV86695"/>
        <property type="gene ID" value="RA11412_0396"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0396"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041479">
        <property type="entry name" value="TetR_CgmR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17937">
        <property type="entry name" value="TetR_C_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="199" mass="21976" checksum="567993B8E55713E8" modified="2018-10-10" version="1">MVIMTTPASASEPRTTRANNSREQILDAYEHLLVQAGERATTLDAVATQAKVSKGGLLYHFGSKKALFQALLDRTRTYADEDLEKMRAAPEGASAYYINTSTFQGTPFDICLVALSRLAQDKNPAARELMDEIQGQWYELIRAEIGDDKMARTVLLLGDGMYYSAAFAGGMANPAARKRIKADRDILLDVLDILRRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWA4</accession>
    <name>A0A2Z5QWA4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_06485</name>
        <name evidence="1" type="ORF">RA11412_0398</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86697">
        <property type="protein sequence ID" value="BAV86697"/>
        <property type="gene ID" value="RA11412_0398"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0398"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="62" mass="6936" checksum="B73C4DC2F1D242E5" modified="2018-10-10" version="1">MVHNLATEEDAFHNISMLGAISRYTNTDTNIIAVQTSTPYGASEEETQRIMRNARNESLPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWB1</accession>
    <name>A0A2Z5QWB1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Threonine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_06555</name>
        <name evidence="6" type="ORF">RA11412_0383</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86682">
        <property type="protein sequence ID" value="BAV86682"/>
        <property type="gene ID" value="RA11412_0383"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0383"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="180"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="354" mass="37835" checksum="B04F0B27F657059F" modified="2018-10-10" version="1">MKAVVYHGAGKRAWEEVPDPTILEPTDVIARVDTTTICGTDLHILKGDVPEVEEGRILGHEAIGTITEVGSAVTDLKVGDRIIIPAVTNCGKCSYCKDNKPSHCQTVGGVGWIFGYMIDGTQAEYVRIPYAETSVHMVPEGLTDEDVLFLTDALPTGFEMGILNGNTKPGDTVAVIGAGPVGLGAIMTANLCGAGRVITVDMDDNRMNKALELGATDKVNAADPDFIEKIKALSPDSLGVDVAIEAVGVPQTFETCTKIVRPYGNVANAGVHGKPVELPINTMWISNVNINMGLVNCNTVGNLLNMVRSGRLNAKAMATHYFTFDQFEEAYDLFANAAEHNAVKVVISREPIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWE8</accession>
    <name>A0A2Z5QWE8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86747">
        <property type="protein sequence ID" value="BAV86747"/>
        <property type="gene ID" value="RA11412_0448"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0448"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="4702" checksum="D361603AEEECF643" modified="2018-10-10" version="1">MLYVPHWLPRTRCFITGRGNQFMYPHGVRLRPWWLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWG8</accession>
    <name>A0A2Z5QWG8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division protein CrgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crgA</name>
        <name evidence="5" type="ORF">RA11412_0437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CrgA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86736">
        <property type="protein sequence ID" value="BAV86736"/>
        <property type="gene ID" value="RA11412_0437"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0437"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00631">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009619">
        <property type="entry name" value="CrgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06781">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV86736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="127" mass="14467" checksum="482436AFD306AF5D" modified="2018-10-10" version="1">MLCGGNYVWFGQGKKKKGSASKSSGAKAKDAKKKQKAEQKKVVARDTLNEERLRKVAEEMEQGQPLRDQTPLWYRVIMFSFLAVGLLWIVVYYIFEGLYPIAGIGMWNITIGIGALMVSMLMMTRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWQ7</accession>
    <name>A0A2Z5QWQ7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0566</name>
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    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
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            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86865">
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        <property type="gene ID" value="RA11412_0566"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0566"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="5050" checksum="94B643A961D930C7" modified="2018-10-10" version="1">MKSQYRGAYSAVLQGLKSPVWRGMKGIWCVKLGRQAMMKDNYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWT1</accession>
    <name>A0A2Z5QWT1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86872">
        <property type="protein sequence ID" value="BAV86872"/>
        <property type="gene ID" value="RA11412_0573"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0573"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="50" mass="5087" checksum="D40ACA4785943E91" modified="2018-10-10" version="1">MMSGASAGRDSWYLFASIGGLESVGRLTLMLAAAFTVPTLVGLEVATVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWW9</accession>
    <name>A0A2Z5QWW9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86881">
        <property type="protein sequence ID" value="BAV86881"/>
        <property type="gene ID" value="RA11412_0582"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0582"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="45" mass="4834" checksum="D47CD9367CB46E12" modified="2018-10-10" version="1">MRSLEGGGANRVLMSRGVLGRVLEPASSIPDLKEKVMHCGRKILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX16</accession>
    <name>A0A2Z5QX16_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-asparagine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86930">
        <property type="protein sequence ID" value="BAV86930"/>
        <property type="gene ID" value="RA11412_0631"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0631"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="78" mass="8991" checksum="26D4DE8BD96A6ED0" modified="2018-10-10" version="1">MTILIPLLVIGWFTVRKRVYEIARVREGYTGSAPIVAQRPVVRKLVHEPRIHVDIEGLGVEDTPRSHRHDDKPKDNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX30</accession>
    <name>A0A2Z5QX30_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">yidC</name>
        <name evidence="17" type="ORF">I6I94_06170</name>
        <name evidence="16" type="ORF">RA11412_0475</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86774">
        <property type="protein sequence ID" value="BAV86774"/>
        <property type="gene ID" value="RA11412_0475"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0475"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="268"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAV86774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QQT88139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="343" mass="38240" checksum="34E1D45F624414A9" modified="2018-10-10" version="1">MPNIFDLILWPFKWAVSAVLWVFHSLFTAIGMDPSSGLTWVLCIICLTLVMRTLTIPLFVKQIKAMRGMSAMQGDIAKLQAKYKGKKDQLSRQAMAQEQMALYKKHGTNPFASCLPIIAQMPIFFGLYQVLMGVSGAAAANEGILMLPADLVKQFSEAHIFGAPIFSTMMNPGDGNHTATVIQAIVMILLMSGTQFFIQKQLSVKNMSEAALNSPMFRQQQMMMYIFPIIFAVTGINFPLGVMYYWTVSNFWALGQQWWVIRNNPTPGSQAEKELNERRAAKGLPPVGKTKEQHEKELEEARERANAGQRQQPMSKKRQKQQRAKGKGGQKGSSGGSQKPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX35</accession>
    <name>A0A2Z5QX35_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86950">
        <property type="protein sequence ID" value="BAV86950"/>
        <property type="gene ID" value="RA11412_0651"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0651"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="42" mass="4629" checksum="B4423891849C3BEA" modified="2018-10-10" version="1">MFSVLDDLEPVRQAAQKAAEQAIQTLKPVGTAHSRVRIQHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX71</accession>
    <name>A0A2Z5QX71_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)H-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05145</name>
        <name evidence="2" type="ORF">RA11412_0723</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888636.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87022">
        <property type="protein sequence ID" value="BAV87022"/>
        <property type="gene ID" value="RA11412_0723"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0723"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="255" mass="26984" checksum="1F123BE398C1498E" modified="2018-10-10" version="1">MKIAVAGATGTIGTKICTELEKRGHQVVPLSRSTGVDASVLESLTPALAGVDVVIDALNHTVMNRRKAEELFKLTASNIAQAAAENQVKRIVCISIAGVQDAAVCRGYGYYSGKAVQENTYKASPVETVIIHSAQWFEILPTLVKQVTFGPVSVLPTMKMSPLPAAPVAQLACDIAEGQMNIPDSGVISIRGAEEGTAAEFVKRILAARGEIGGKHPKLVWQLPYLGSAIAKGGLIPDPADRTDPTTLNDWLTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX75</accession>
    <name>A0A2Z5QX75_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86990">
        <property type="protein sequence ID" value="BAV86990"/>
        <property type="gene ID" value="RA11412_0691"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0691"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="489" mass="50764" checksum="C6794924C3582947" modified="2018-10-10" version="1">MPLAALAACAREEQPEQSPQNTAESAAPEASAAAPEFPQLQKLLADRAGAHRSALVTHTDGNIVYGEGENEPRAAASAMKVLTYLALAHSIDLGTRFKTSVARNGNELTLIAGGDTMLGAGDSKKDAVNGYAGLGTLAGACVESLRSAKTEKGKFPVFLDTSIYTGPELNPGWEKPDIDSGQITGISPIALDSHTIAGKSGPYGTPARPTDAASAAQQAFVDALNKAGEPHGYSFERKDKRTKPSDATEIASVESATALQQAQHMMLESDNTLAEALTRNAAIAAGRQGSAEEAQKLVREKIEAAGVTTEHLKQADVCGLSLENRVTARMLVQALAKLLEHPRHEELLQGLPVAGKTGTLKERFTEPDAVDARGHVRAKTGTLFTVVALAGYTTRPDGTRLIFALILNDTDSIGGLPQAKKVADAAAAVISDRAPKPSPSPSDSSHSAGEHSPSESAKPAESPKATDTSTSNAPVTLAPAGEPAPTEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX78</accession>
    <name>A0A2Z5QX78_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparaginase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">L-asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_05075</name>
        <name evidence="4" type="ORF">RA11412_0739</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87038">
        <property type="protein sequence ID" value="BAV87038"/>
        <property type="gene ID" value="RA11412_0739"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0739"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparaginase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="168" mass="17731" checksum="AFAFDDBDAC207B8D" modified="2018-10-10" version="1">MSSIRNPEKVTILATGGTIDKFYSVAGTLDIGAPAAQDLLDRVITDIKFEIRPLIGKDSLDMTDADRAELAAALNAVRGEQVIITHGTDTMSETARYLAEHADVGQKTVVLTGAMQPAVMARSDAGFNLGAALSAVNLLPPGVYISMSGRIFPAASVRKDRARGIFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXG0</accession>
    <name>A0A2Z5QXG0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dipeptide transport system permease protein DppB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87122">
        <property type="protein sequence ID" value="BAV87122"/>
        <property type="gene ID" value="RA11412_0823"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0823"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4655" checksum="E1A5E7CD1330D3A0" modified="2018-10-10" version="1">MVFITTTMGYFAAVITLQPALLEQEKFPGRPQNRFNVTLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXG4</accession>
    <name>A0A2Z5QXG4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">radA</name>
        <name evidence="5" type="ORF">RA11412_0727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="2">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87026">
        <property type="protein sequence ID" value="BAV87026"/>
        <property type="gene ID" value="RA11412_0727"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0727"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2 3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0346">Stress response</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="4">
        <location>
            <begin position="24"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="2">
        <location>
            <begin position="323"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="2">
        <location>
            <begin position="224"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="429" mass="44874" checksum="B9B0D2D6AC929E10" modified="2018-10-10" version="1">MARTRTASSVQKPAQVIGEVDSTVAAYMSTGNPEFDRVLGGGLVPGAVILMAGEPGVGKSTLLLDVAATFARGYTPRTPAAERARAKTRDVLYVTGEESAAQVKLRADRIHAVADTLYLTSETDLGTALAHIEQVDPALLVIDSVQTLASADVEGSAGGVTQVREVAASLIAAAKARNMCTLLVGHVTKEGTIAGPRLLEHLVDVVCQFEGDKHSNIRMLRAIKNRYGPTDEVGCFDMHEDGIAPVLDPSGMFVSRTPHPVAGTCVTVTMEGRRPLLAEVQALLDQAVAPAPRRTVAGLDSARIQMLLAVLQRRAGLNVGKLDCYVSTVGGAKIAEPAADLACVMALASAAQNKPLPRKLAVFGEVGLAGEVRAVPGIRQRIAEVGRLGFTHVLVPASPTGVGQVPDGVTVREVATLGEALNLLFPQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXJ7</accession>
    <name>A0A2Z5QXJ7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87177">
        <property type="protein sequence ID" value="BAV87177"/>
        <property type="gene ID" value="RA11412_0878"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0878"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="114" mass="12784" checksum="2B0F1D3A12A10ED8" modified="2018-10-10" version="1">MHDIRGSQVDQHRGAWLYSHFWMEAAEGVLHQDADWMREPVISASPIVGADAVVELEYYPRDPEWIPEWMTAKIAEYHEEEARECQKTDTEAAQAEGNGAGEPSSGRGGRSAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXN0</accession>
    <name>A0A2Z5QXN0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87208">
        <property type="protein sequence ID" value="BAV87208"/>
        <property type="gene ID" value="RA11412_0909"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0909"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016462726" evidence="2">
        <location>
            <begin position="20"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="205" mass="20791" checksum="7656D09D545FDFF3" modified="2018-10-10" version="1">MNTAHPMTAPSNTPAPARAATHAGHPAAAPTPRPHSFAAPAAPGAVGIHTSNDLSPLAPLLVSSATSDPSTAAPAGTITAAQPTTQNPEEPAAESRNMPAIIGTAENPTAREIALRAMRILLGESSEYGREACENALQTAIDEREESISATVTLAPERPASSETAQEPAPSAHPENPDDTPAAPCTTPPCATCTTSCTAWGHSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY83</accession>
    <name>A0A2Z5QY83_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative endoribonuclease L-PSP</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">RidA family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">RidA/YER057c/UK114 superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_04455</name>
        <name evidence="4" type="ORF">NCTC10207_00364</name>
        <name evidence="2" type="ORF">RA11412_0895</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888354.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87194">
        <property type="protein sequence ID" value="BAV87194"/>
        <property type="gene ID" value="RA11412_0895"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0895"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI22289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="160" mass="16722" checksum="A9C047B9958B828B" modified="2018-10-10" version="1">MTEPRIEQRIRDLGYELPEVAAPVAAYVPAVVSGSYVYTSGQLPFTKGELPAIGKVSASGQAGFVAPEDAKKYAAICVLNALAAVKSVIGDLDRVRRIVKVVGFVSSEPNFTGQPGVINGASELLGEIFGEAGQHARSAVGVPVLPLDSPVEVEIIVEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYF0</accession>
    <name>A0A2Z5QYF0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">gatA</name>
        <name evidence="10" type="ORF">I6I94_03360</name>
        <name evidence="11" type="ORF">NCTC10207_00598</name>
        <name evidence="9" type="ORF">RA11412_1183</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037232795.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87482">
        <property type="protein sequence ID" value="BAV87482"/>
        <property type="gene ID" value="RA11412_1183"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1183"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="50"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VEI22520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="532" mass="55676" checksum="736FB88A605E05CF" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYH0</accession>
    <name>A0A2Z5QYH0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87331">
        <property type="protein sequence ID" value="BAV87331"/>
        <property type="gene ID" value="RA11412_1032"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1032"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="262" mass="30004" checksum="E0D2E80AA6393E45" modified="2018-10-10" version="1">MGIFGIGKKKWEAQVRAAEEAAAAEAEERSLSEKVMEQQQWEESLRKFVRTESQRSQGQRVVEENARHTAASEDFFEEHDQDSTDSANLVHPGAEEQELEATTSESSTQTQEPEDDYDTDDAPAQDPYDDEGYDASAEYEDDYDDEDDDYDDEDEDEETRQARVKDYMTRLGLTNDDNDPEQKIELVTDETVLLHLPDTPEEDAHTTVTEPETYAGRCRLSRLKIRGRRCKKQPIPGRLLRRTIVRTTPKTSSTMCLQGRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYH5</accession>
    <name>A0A2Z5QYH5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">pyrH</name>
        <name evidence="9" type="ORF">I6I94_03200</name>
        <name evidence="10" type="ORF">NCTC10207_00636</name>
        <name evidence="8" type="ORF">RA11412_1219</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006889002.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87518">
        <property type="protein sequence ID" value="BAV87518"/>
        <property type="gene ID" value="RA11412_1219"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1219"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="23"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="144"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VEI22555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="248" mass="27373" checksum="9605BF396257C121" modified="2018-10-10" version="1">MKESIAHPLYEDSNRHRRRVLLKLSGEVFGGGEVGISTEVVRNIARQIAATVGEVETSIVIGGGNFFRGAELSQAGMDRSRADYMGMLGTVMNSLALQDFLEQEGIDTRVQSAITMPQVAETYIPRRAIRHMQKDRVVIFGAGAGLPYFSTDTVAAQRALEIHADEVLVAKNGVDGIYTADPNKDPNAERLYNLTYDEAMQRNIRVLDQTAFSLCRDNNVTMRVFGMQGEDNVTRAIKGEKMGTLVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYM1</accession>
    <name>A0A2Z5QYM1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03465</name>
        <name evidence="2" type="ORF">RA11412_1154</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888179.1">
        <property type="nucleotide sequence ID" value="NZ_CP068102.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87453">
        <property type="protein sequence ID" value="BAV87453"/>
        <property type="gene ID" value="RA11412_1154"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1154"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="96" mass="10383" checksum="3A34D1884400F894" modified="2018-10-10" version="1">MIPLSRRVLTPRTPGGWALFMGRIAAAVLLVLVTLGACVWAFFGQDAFMAYLAVAVFALIAAGCGTYAAVFFLAHRTKVRKGEYGMSGPVQFRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYM3</accession>
    <name>A0A2Z5QYM3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_03065</name>
        <name evidence="1" type="ORF">RA11412_1253</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87552">
        <property type="protein sequence ID" value="BAV87552"/>
        <property type="gene ID" value="RA11412_1253"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1253"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="121" mass="13663" checksum="87BFC92F366BC696" modified="2018-10-10" version="1">MIEPHSIEYSPSNEDGLAYVYFSYGQHEYFTLARTPEEEPVIYLERNDQSLALESNNVSYTLSGNTVVFTMGEDIQQALQVGSVLEVLVNLDDRHLPEFRRALAAIFPVARSSQGAEHPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYP8</accession>
    <name>A0A2Z5QYP8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_1296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87595">
        <property type="protein sequence ID" value="BAV87595"/>
        <property type="gene ID" value="RA11412_1296"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1296"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="5">
        <location>
            <begin position="55"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="186" mass="20800" checksum="7F32C86539ADE5AE" modified="2018-10-10" version="1">MADALRLAEDAELDLVEVAPNAKPPVCKLMDYGKYKYEAAVKARESRKKQVKAVLKEIRFRLKIDTHDYETKVGHARRFLSGGDKVKAMIQFRGREQQRPEMGVRLLERLAEELAEVSTVESRPRQDGRNMVMVLAPLRGKAEVRRGQGGGGRKGRERIDTTKAEPVTNSLADAMPAELKAQASAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYQ1</accession>
    <name>A0A2Z5QYQ1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="11">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="11">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">gatB</name>
        <name evidence="15" type="ORF">I6I94_03355</name>
        <name evidence="16" type="ORF">NCTC10207_00599</name>
        <name evidence="14" type="ORF">RA11412_1184</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="15 19" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 19">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="11"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888206.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87483">
        <property type="protein sequence ID" value="BAV87483"/>
        <property type="gene ID" value="RA11412_1184"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1184"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="13">
        <location>
            <begin position="350"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV87483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QQT89660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VEI22521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="501" mass="54645" checksum="F4455504E5CE4CD0" modified="2018-10-10" version="1">MSEEILSFEEAIEKYDPVLGFEVHVELNTKTKMFDAAPNEFGDEPNTNISPVSLGLPGVLPVVNKAAVESGIKLGLALGCDIAPLSYFARKNYFYPDTPKNFQTSQHRDPIAENGKLDVELEDGTVFTVEIERAHMEEDAGKLTHVGGADGRIQGAAFSLVDYNRAGVPLIEIVTRPIVGAGERAPELARAYVAAIRDIVKSLGISDARMERGNVRCDANVSLMPKGAEKFGIRSETKNVNSLRSVERAVRYEIRRHAAILERGEKVLQETRHWHEDTRETSSGRPKSDADDYRYFPEPDLVPIVTNTEWIEKLRASLPEPPAERRRRLKNEWGYSDEEFRDVVNAGALDVIEQTIAAGASASAARKWWMGEIARQAKQAEVELTALGIEPVTVVELETLIAEGKINDKIARKVLEHVLAGEGKPAEIVEARGLAVVSDDGALTAAVEEALAAMPDVADKIRAGKVQAAGAIVGQVMKATRGQADAARVRELILQACGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYR4</accession>
    <name>A0A2Z5QYR4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SseB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_02915</name>
        <name evidence="2" type="ORF">RA11412_1293</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87592">
        <property type="protein sequence ID" value="BAV87592"/>
        <property type="gene ID" value="RA11412_1293"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1293"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT90071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="227" mass="24587" checksum="EDBF1058E4784F08" modified="2018-10-10" version="1">MKAFAAGEANETAVVDALREARVFVPVVAQLSQVHLTAEGLVSDKETDMALVSIQSPDGRRALPVFTCVDYLTQWHAQARPVAASMRKTSLSAVEDNNQLIVVNPGQDPTFVVRRPAIWAIAKEQPWVPSYNHEAVSQDVRQLIRLMPQVEDVQLAAAAGADSRSAKGRILAGGGHGPELEITLVLKPGMTREQLDTTITDFQQRLAASEVISELVDSVQIKLSQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYU6</accession>
    <name>A0A2Z5QYU6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Segregation and condensation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87637">
        <property type="protein sequence ID" value="BAV87637"/>
        <property type="gene ID" value="RA11412_1338"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1338"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="327" mass="35425" checksum="4269DEB047A16A6F" modified="2018-10-10" version="1">MEHRSPMTETVAAERVPTPTGPNSPTPPVPGAGFTLTLTNFEGPFDLLLTLISRRKLDITDIALAEVTDEFIAYLHALYEHGTAEALDEASDFMVTAATLLELKAARLLPHHNDPLQQDVALVEARDLLFARLLQYRAYREVAAIFAARWQAENQRFARTVALEPVFAKALPELVFEEGPEEFARIAAAAFAPKTRPAEPEPEVIVEELNEHLHVSTTTIAAEERTILDALLAGAPAVRSVRFSELVRGAGELETAVVRFLALLELYKEGAVTLNQDAPLGEISVSTTALSRDFVPHDPADSTMAGSETVPAVAAPELQAHPGKGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYW0</accession>
    <name>A0A2Z5QYW0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenosylhomocysteine nucleosidase</fullName>
            <ecNumber evidence="2">3.2.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mtnN</name>
        <name evidence="8" type="ORF">I6I94_03095</name>
        <name evidence="7" type="ORF">RA11412_1247</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.9" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87546">
        <property type="protein sequence ID" value="BAV87546"/>
        <property type="gene ID" value="RA11412_1247"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1247"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008782">
        <property type="term" value="F:adenosylhomocysteine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008930">
        <property type="term" value="F:methylthioadenosine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010049">
        <property type="entry name" value="MTA_SAH_Nsdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01704">
        <property type="entry name" value="MTA/SAH-Nsdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="6">
        <location>
            <begin position="38"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="296" mass="31227" checksum="4276C6FB7A182FFE" modified="2018-10-10" version="1">MSDSPFAAAQMNPDEVYTAMLADLENLNDLMLNFSNAVIIQVAMDEEIAPLLNATAWAQEPIDEGAAVFHPRTLTVNQREVPLLLVRSKIGLVNAASAVTEALSYATDCSGVISAGTAGGLAATTNVGDVIVGTEYTYTDADASAFGYVRGQIPGMPETYGGPDSDVDDAVAAAVEALDAEQAEGGWQVCRGLMLAGHSFVTAHNVKDTREAFPAALSTDMETTAIAQVCHNYEVPFVAVRCVSDLCGPAAGQDFHLGVEVAAARSAQYALRVAAHLWFLRGYTDDTEDTEQESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYW5</accession>
    <name>A0A2Z5QYW5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TolA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87658">
        <property type="protein sequence ID" value="BAV87658"/>
        <property type="gene ID" value="RA11412_1359"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1359"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="429" mass="50963" checksum="BD59340089EBB87A" modified="2018-10-10" version="1">MDFNDYYDILEIDDSAAESEIKVAIRKTRSRYRNLTGSPNKDQARKAEHMIDVLAEAEKVLYDPAARADYDQKLAIYRTKKILNNDEREESSLSEEEIRREYELRLEKEWQRRERKLRDEYKKRKEERHDDSIIEEDISDDEFLDRYEERLERARQERAAREERERQERLERERQARAERERLHKLAQEKRAKEEAARWEKQVTSYLEDQNRDYKALHYAAQQLTSYNSRSAIGWQALAMAQYDRGEFPAAATSIRQAKQLSSTPSDDLLSLEALIAIKNGNYTQALANYRHLIQEYPDNQKYIAQYIQALTVSGDPQHAVSESERALAVHPNSSEIKKQYAVSLMREAQSYSVPYDGLLYVASRQQLRNARKAFAKVPKPHMLPEDIRPIYHQVADHMKIATKRRWTGNFRLMFLYFYFWVGQWCLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ37</accession>
    <name>A0A2Z5QZ37_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_02445</name>
        <name evidence="5" type="ORF">RA11412_1409</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87708">
        <property type="protein sequence ID" value="BAV87708"/>
        <property type="gene ID" value="RA11412_1409"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1409"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="47"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="272" mass="29270" checksum="B6DF944D195F6CB3" modified="2018-10-10" version="1">MSTNSLTYTADRADQLARGYQRVVERIRAAEQDTSGARSAQSETVQLVTVTKFFPASDVMALYDAGVRLFGENRDQEAAPKAALVSESVPFHDPARWAFIGQLQTNKAKSVVRYAQQVQSVDRPSLADALAKAYARQVERFETEQAPAPAAYKAGKLECLIQVSLAQGQATAGHASTGARGGADPEQVLALAEHIENYEQLHCAGVMAVAPLGSEPDMVFEKLWNISQILRESFPQATQISAGMSGDLEAAIRWGSTCVRVGSDIMGPRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ68</accession>
    <name>A0A2Z5QZ68_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">I6I94_02255</name>
        <name evidence="20" type="ORF">RA11412_1453</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 23">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 17"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023134621.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87752">
        <property type="protein sequence ID" value="BAV87752"/>
        <property type="gene ID" value="RA11412_1453"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1453"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 17" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="348"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="BAV87752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QQT89473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="427" mass="44242" checksum="5D9ECE957B93D795" modified="2018-10-10" version="1">MTDTIKVALLGAGNVGSQVARIFSEDSAVLKERIGAPVELIGIAVRDTAAKRHWDADPGLYTTDADALIDAADVVIELTGGIEPARTRILRALEAGKSVVSGNKALLAKHGVELQAAADKSGAQLSYEAAVAGAIPILRPLRDSLAGDTVTRVLGIMNGTTNYILDQMDTTGATFADALKDAQELGYAEADPTADVEGHDAASKAAIVASLAFHSDFTIDDVHVEGITAVSADDVAAADADGYVIKLLSVCERDGEGVNIRVAPTLIPRQHPLAGVHGAFNAVFVQAQNAGELMFYGPGAGGAPTASAVLGDFVSLARRLVLGGPGVPESSYAQLPATGLGDIISRYSVGMLVDDKLGVLANISRIFAEHGISVDSLRQSTPQDGAAQIRLVTHSAKDSDLRRAIAVIDGLDTVREIISVIRVESGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ69</accession>
    <name>A0A2Z5QZ69_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87524">
        <property type="protein sequence ID" value="BAV87524"/>
        <property type="gene ID" value="RA11412_1225"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1225"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="4465" checksum="97AFA57CDD394ABF" modified="2018-10-10" version="1">MPCALHRAPFLVRYRYGFLGSGATVAAEGSGFGALEDFSGEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ81</accession>
    <name>A0A2Z5QZ81_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phenylalanine--tRNA ligase beta subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RA11412_1312</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87611">
        <property type="protein sequence ID" value="BAV87611"/>
        <property type="gene ID" value="RA11412_1312"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1312"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="12">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="13">
        <location>
            <begin position="338"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV87611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="442" mass="47146" checksum="A5800FB80384408B" modified="2018-10-10" version="1">MQGIICGAHNFKVGDKVVVTLPGAVLPGNFAITARKTYGHKSAGMIASTRELGIGEDHGGILVLSTLGLDPELGSDALELLGLYDEAAEVNVTPDRGYAFSIRGIAREYAHATGTSFNDFVLEYGARAPKANSEGIPVRLEDSAPIHENPATIRFVMRRVNGVDATAPVPTWMASRLRLAGVRSISLPVDISNYVMLETGQPLHFYDADKVQGEIVVRRAVAGEKLTTLDGVERDLHPEDIVITDDSGVIGLAGVMGGASTEVTAETKNILIEAARFDEVSIARTARRHKLISEASKRFERGVDPQIQQAAAQRAVELLTQLAGGTADAGVTDAALPYHPVVIDLPSGYTAGRIGVDYSQEQIVACLSEIGCDVEKTGNGYSVTVPSWRTDLLAKEDLTEEIARIDGYDKIPSSLPVAPAGRGYTPSSRCAAVLWTHLPRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZE6</accession>
    <name>A0A2Z5QZE6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FtsX-like permease family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Putative ABC transporter integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I6I94_01890</name>
        <name evidence="9" type="ORF">RA11412_1543</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888668.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87842">
        <property type="protein sequence ID" value="BAV87842"/>
        <property type="gene ID" value="RA11412_1543"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1543"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="799"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="847"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="892"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="295"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="831"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="561"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="929" mass="99742" checksum="996C4ADBAB2D8BDA" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZF1</accession>
    <name>A0A2Z5QZF1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87875">
        <property type="protein sequence ID" value="BAV87875"/>
        <property type="gene ID" value="RA11412_1576"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1576"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="60" mass="6590" checksum="BBDA376547DFD98C" modified="2018-10-10" version="1">MVFPAYVGMSPQWARQKNFLPVFPAYVGMSPFNETGFSDDLGVPRIRGDEPTSKPSTGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZF5</accession>
    <name>A0A2Z5QZF5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fumarylacetoacetate hydrolase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Ureidoglycolate lyase</fullName>
            <ecNumber evidence="5">4.3.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_01860</name>
        <name evidence="5" type="ORF">NCTC10207_00921</name>
        <name evidence="3" type="ORF">RA11412_1553</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.3" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888677.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87852">
        <property type="protein sequence ID" value="BAV87852"/>
        <property type="gene ID" value="RA11412_1553"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1553"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018833">
        <property type="entry name" value="DUF2437"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10370">
        <property type="entry name" value="DUF2437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2437" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="73"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI22833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="251" mass="26792" checksum="74D8271854EEDAA2" modified="2018-10-10" version="1">MRIARFTVDDELHFGLVEGEEGAETLRVLAGDPFYNGIEPTGATHRLDDVRLLAPIIPRSKVIGAIANWAGTPAPAAPQFFTKPNTTVVGPGDPVTLPDYSEAVSPEGELAVVIGRIAKSVPLERVPEVVFGYTVANDLTARDVMDTDAQWTRAKSFDGSTPLGPWIETQLDTDSLNITTWVDGDTLQEGNTSEMHYSVAELVAAASEVFTLLPGDIILTGTPAGTTVLHEGNEVEVEVEGIGALVTRIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZK4</accession>
    <name>A0A2Z5QZK4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-Acetyl-D-glucosamine ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87888">
        <property type="protein sequence ID" value="BAV87888"/>
        <property type="gene ID" value="RA11412_1589"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1589"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="61" mass="6528" checksum="E7CADEB554383DD7" modified="2018-10-10" version="1">MNQSFGNSGSSPRMRGTPEGEGQEDDVEGLIPTYAGNTESATTRTLPVRAHPHVCGEHGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZK5</accession>
    <name>A0A2Z5QZK5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-Acetyl-D-glucosamine ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87877">
        <property type="protein sequence ID" value="BAV87877"/>
        <property type="gene ID" value="RA11412_1578"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1578"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="137" mass="14750" checksum="DE78093A962BCB3F" modified="2018-10-10" version="1">MSLSRRAHPHVCGEHQSPGGRTLSNGGSSPRMRGTQTQNGTHRSTAGSSPRMRGTRRMFHVPYEEAGLIPTYAGNTDSGISTRPRSGLIPTYAGNTTGTTETSKSLRAHPHVCGEHHGHNRNLEKLEGSSPRMRGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZP2</accession>
    <name>A0A2Z5QZP2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Octaprenyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87684">
        <property type="protein sequence ID" value="BAV87684"/>
        <property type="gene ID" value="RA11412_1385"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1385"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="219" mass="23660" checksum="68E13D83AEB852E7" modified="2018-10-10" version="1">MFARTGVGSLPDRTARTVFDTMRTEVMAGQYLDVLSEVIDSEDYDAALQRAQNVIRYKSAKYSCEHPLTLGGALALDAQQNQHHPILNAYHSFGLPLGEGFQLRDDQLGVFGEPETTGKPAGDDIREGKRTVLVALTEKNADQAGRSLLETCLGNPNLDVHDVQRVRGLMLSCGAVAQLEELIARKSAAIDTALAALPVPEQVREALEAIAAKALHRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZQ3</accession>
    <name>A0A2Z5QZQ3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">mraY</name>
        <name evidence="9" type="ORF">I6I94_02485</name>
        <name evidence="8" type="ORF">RA11412_1395</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87694">
        <property type="protein sequence ID" value="BAV87694"/>
        <property type="gene ID" value="RA11412_1395"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1395"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="401" mass="42652" checksum="0A2056D4FEE861FD" modified="2018-10-10" version="1">MITVLIAGVLGFVLSFGAIPLFIRQMQKLKLGQLIRDEGPAAHQHKAGTPTMAGLVFIPAAVLAYFIALLLSAWFYGTSPAPSATAWLTLGFTVGMLAVGAADDIMKFRNKGNEGLTEIQKTVGLLAVTLPFSYLAFQFPNSAGVTPASTAVSFVRDLPLDLMAPGAIVGTLLVMAWINLIALSGTNAVNFTDGLDGLAGGVMMTIFTGYLAMTVWQYSHRCVSAAGVGCYDVRDAGALAMIAAAFVGSLGGFLLWNVSKAQIFMGDSGSLALGGALVAFAIFTRTELLLPIIALVPVLEVFSVIVQKFVFKFSRKGSVSRGEKVPHAHRFFRMTPFHHHMEKTGVNGMYSIDKKGIAPGTVSSGEVNSVFRLWVVNALCVLIALALFFGDWFSQNTGVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZR7</accession>
    <name>A0A2Z5QZR7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CRISPR-associated helicase Cas3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">CRISPR-associated helicase/endonuclease Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I6I94_01835</name>
        <name evidence="11" type="ORF">RA11412_1557</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888657.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87856">
        <property type="protein sequence ID" value="BAV87856"/>
        <property type="gene ID" value="RA11412_1557"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1557"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041372">
        <property type="entry name" value="Cas3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF5">
        <property type="entry name" value="PTHR47959:SF5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18395">
        <property type="entry name" value="Cas3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18019">
        <property type="entry name" value="HD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="10">
        <location>
            <begin position="29"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV87856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT89396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="994" mass="110687" checksum="3FAB2024BFE12A2D" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZS5</accession>
    <name>A0A2Z5QZS5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87791">
        <property type="protein sequence ID" value="BAV87791"/>
        <property type="gene ID" value="RA11412_1492"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1492"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="213" mass="23260" checksum="E5FAA7EFE1E0F46C" modified="2018-10-10" version="1">MDRPTVERRLMACLLVGESDIACYTEVFEPFLDDGEGHILIPPQKLEEYAQALLASRRAYAKEIGIEGCRGNLVCAFEALERTGIIAYPDGNWCGIPEEGPEDGTTRYGYVSLSAESAEALLLYDAAQLHCGTFSDTGEVSDQEIHDADCAIIQNRIIPVLEGHGVEVKWNGTAVDFPLVTNTGFLPSPNRSQTEPGHYLLPTNQSASLSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZU4</accession>
    <name>A0A2Z5QZU4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Single-stranded DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87978">
        <property type="protein sequence ID" value="BAV87978"/>
        <property type="gene ID" value="RA11412_1679"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1679"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016232922" evidence="1">
        <location>
            <begin position="32"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="408" mass="40974" checksum="4DC9EBD2367C8787" modified="2018-10-10" version="1">MKGNISRRGLVKGTAWAVPVVLASTAVPALAASHCQPGIVVPIPTNTSTDGSSLTHTFTATDKTQSLTFTITGGAGGSYQGDSYQGFGGAGAYITGTIDLTEGDTVTFITAGGGGPYSGSAEAPGRGWADGGSHEAAYIGTNSYTNAFQEGPGRVTELYGPTGGGASAVLLNGTPLAIAGGGGGGGARQISRTTWSKIYGERPSGFKGLRFNHGNIANGGTGGPSYTGGEGYDETYEYFPGPSLHMNGGKGGYNGWAGAGGEAGNLLNPTSNSSLSFKNNSTYYTYRQSLAGNAGDNGYLTTPTGGTGGKGVVGIGMVVTIGSTHADRNQCSVLHGSTGGGGYGGGGSGSVTTAAGYATDQRWAGEYTYVNGEYQAGDYWSPWAQLRSLGPVVREGRILTTSGCIADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZX6</accession>
    <name>A0A2Z5QZX6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87764">
        <property type="protein sequence ID" value="BAV87764"/>
        <property type="gene ID" value="RA11412_1465"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1465"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="32"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="251" mass="27117" checksum="EC562D7198BD200B" modified="2018-10-10" version="1">MAGVYPLHFPGRYGSSQAPVIVPDTDKTPDFSVLMSVYAEEIPEYLDAALASNAREQSLRPTELVLVLDGPLTPELNTVIERWVAEGQAGRCAPIRTVPLPQNAGLAAALNEGLAACTHELVARADSDDISEPSRFERLIPALAASDCAVLGSAMHEVDAQNTVCEAKRSTVLGAERVQAAMPSRNPLYHPTVAFRKTPVQQVGGYEYVPGAEDWWLWSRLAAAGYKLDNLSEALVRYRVGAGAYTRRGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R033</accession>
    <name>A0A2Z5R033_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88092">
        <property type="protein sequence ID" value="BAV88092"/>
        <property type="gene ID" value="RA11412_1793"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1793"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="124"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="359" mass="38188" checksum="1888BD00CFDC4EBD" modified="2018-10-10" version="1">METPVYGLDTAFAATLQSANYDPHKHRTIAILSEYDALPGIGHGCGHNVIAAAGLGAFLALADTLRKTPEAFSGRIIYLGTPAEESDAGKENMARAGAFDTADAAIMVHPYFIDVADQAWLGRRECRVTYRGISAHASSHPFMGRNALDAAALAYQGLGLLRQQLPVSDRIHAIIDSGGQTPNLIPQTASLHINIRSRYAPTLRALSHRIEDVLHGAALMAGVQADIRWDSSPMTMPVRSNQTLGQRWVLAQREIGRNPYPAGTISDTLAASTDFGNISLRLPGIHPLIQIAPEGTGLHTAEFAAAAQSPRAEEAALDGAYGLAVVALDFLTDDALAADVQAEFEKAGGAVQVQTYFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0R0</accession>
    <name>A0A2Z5R0R0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Haloalkane dehalogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88375">
        <property type="protein sequence ID" value="BAV88375"/>
        <property type="gene ID" value="RA11412_2076"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2076"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="69"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="403" mass="45484" checksum="E3280F69BE3EE8C6" modified="2018-10-10" version="1">MRHLNFPKTQPTYNPQEWTGVDPRYSHRLEVPTTAPIEARANQAQARRWHYLDNLPVLQQQGLESIGTVLCVHGNPTWSYLWRTVLDAGVNTENPWRVVAVDQIDMGYSERTHLDLEGERRSLEDRIADLGDFTRETGLDETKQPLVILAHDWGGLVSLGWALEHKSILSGVMLTNTAVYHDGIERIPAPLRLALSVHELGTKDSTAFLDVTLGLAQNRGRLPDPGTPGAAEAALAGPTVHQPRALYPYKLDEGIRRTYRAPYAHPAWREGIRNFVGDIPTGADIPSYEHMVRIAEGIRELKVPAFFQWGTKDPVFQRRYLFDLMRRMPQAKVHRYEKASHLLAEDYDIATPIFSWLGQNFGVLAEGTLQEPVNAEAAHRKARQELDHLHRGDTPITPDSGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0S9</accession>
    <name>A0A2Z5R0S9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation elongation factor LepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88253">
        <property type="protein sequence ID" value="BAV88253"/>
        <property type="gene ID" value="RA11412_1954"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1954"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="17"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="226" mass="24470" checksum="0A7834AE5D54510A" modified="2018-10-10" version="1">MAPLSKNPPVPAATDPAIIRNFCIIAHIDHGKSTLADRMLQATGVVAPRDMKAQYLDRMDIERERGITIKSQAVRMPWEVEGTSYALNMIDTPGHVDFTYEVSRSLAACEGALLLVDAAQGIEAQTLANLYLAMENDLTIIPVLNKIDLPAAMPDKYAEELAHLIGCEPDEVLRVSGKTGEGVEALLDRIVEGIPAPEGTADAPARAMILTPCTIHTAVWSPMCVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0W3</accession>
    <name>A0A2Z5R0W3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)H steroid dehydrogenase-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_11110</name>
        <name evidence="3" type="ORF">RA11412_2079</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88378">
        <property type="protein sequence ID" value="BAV88378"/>
        <property type="gene ID" value="RA11412_2079"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2079"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003854">
        <property type="term" value="F:3-beta-hydroxy-delta5-steroid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3Beta_HSD" evidence="2">
        <location>
            <begin position="37"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="378" mass="40399" checksum="F81C49C8EAB87005" modified="2018-10-10" version="1">MTNPAPLAARYTDPSPRSLRPVEESDFAPSNAERVLLTGASGMLGRESALALLRAGYTVRVFQRSDSGIAALLPDTIRPRFEQVRGSLTNRQAIEQALTGVNGIVHAAAKVSVSGDWRDYERVNIEGTKSLLDAAVEHAIPKFLYISSPSVAHAGAALVGAGNGDASPEHARGNYARSKAVAEKAVLQMNGTALSTGEHLCTGALRPHLIWGPGDTQLVERILERARAGRLPLLSGGTGLIDTLYIDNAADAVVHGYERLEALAGRAVVVTNGQPRTVAELMSGFCTAVGVPAPRFSVPAPVAVVAGRLIEKVWALLPHSVTAGDEPPMTGFLAEQLSTAHWFDQRNTRELLGWEPAVSIEEGYERLRLFYGDKYSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Y4</accession>
    <name>A0A2Z5R0Y4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type Fe3+-siderophore transport system</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_10865</name>
        <name evidence="8" type="ORF">RA11412_2146</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888690.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88445">
        <property type="protein sequence ID" value="BAV88445"/>
        <property type="gene ID" value="RA11412_2146"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2146"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="350" mass="35584" checksum="63FAB7F4ED46910B" modified="2018-10-10" version="1">MSTTTQRAEVPTTALSGHGAKTAQRITWLIVFAALLGASIIASLLFGSNNSISLQAVLDAFNGTASPQTSIIVFEQRIPRTIVGITCGAALAVAGSLMQSLTRNPLAEPGLMGVNAGAAVAVVLSVFIGGVMGIWQYMVVAVIGAAIAAAAVYVLGRGKDGSIVKLALAGVAISAALGSFTQGLILINQDAYNEFRLWVAGSLEGRGVAIAAAIGPVIAAGVLLAFFVAPAINALSMGEDAAISLGVSVQTTQNLTLLAVTVLAGAATAAIGPISFVGLAVPFVVRALLGNDVRWVNIGSALLGPVWLLGTDVLARVLQHEHETQVGIVATLAGAPVFLFLMTRRKVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Y8</accession>
    <name>A0A2Z5R0Y8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88313">
        <property type="protein sequence ID" value="BAV88313"/>
        <property type="gene ID" value="RA11412_2014"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2014"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="87" mass="9225" checksum="C09AD75EC23C5D2A" modified="2018-10-10" version="1">MLGECVECEGEEEELADVVVAVSLGDSSAFFELESGTHPVSAAAPSALKPNSTVRRDGAETTVGRGVIMVVPLFTMYCMYFYRGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R144</accession>
    <name>A0A2Z5R144_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_1905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88204">
        <property type="protein sequence ID" value="BAV88204"/>
        <property type="gene ID" value="RA11412_1905"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1905"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="93"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="440"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="708"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="788" mass="88092" checksum="3A809090E71A8957" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R171</accession>
    <name>A0A2Z5R171_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_2236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88535">
        <property type="protein sequence ID" value="BAV88535"/>
        <property type="gene ID" value="RA11412_2236"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2236"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014276">
        <property type="entry name" value="2-oxoglutarate_DH_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02927">
        <property type="entry name" value="SucB_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="433" mass="44746" checksum="5FAF1E66725E5671" modified="2018-10-10" version="1">MPALGESVTEGTVTRWLKEVGEQVEVDEPLVEVSTDKVDTEVPSPVAGTLLEIRIQEDEDAEVGQVLAIIGDASAAAPAPAAPAAPAPVAEAPAAAAPAAPAAPAAETPAPAAGVPATADGEAYVTPLVRKLAKDNNIDLSTVKGTGVGGRIRKQDVQAAIAAKGSAAPAAASAAPAAAAGASKAPHTFEVSPKRGTVEKTARIRQVIAKRMRESLDTSTQLTQVTEVDMTRVAQLRAKAKDGFLAREGAKLTFLPFFAQAVTEALQQHPALNASMTEDLKQITYPDSENIAIAVDTPKGLLVPVIRNASDLGIAGLAKAIADLGGRARTGDIAPEELAGSTFTITNIGSFGALFDTPIINQPNVAILGTGSIVKRPMVVKDVDGNDSIAIRSMCYLSLTYDHRVVDGADAGRFLYTLKTRLEEANFEAEVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R181</accession>
    <name>A0A2Z5R181_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88432">
        <property type="protein sequence ID" value="BAV88432"/>
        <property type="gene ID" value="RA11412_2133"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2133"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="139" mass="15619" checksum="10B4905FA0895637" modified="2018-10-10" version="1">MYTLNTLPKFSYIRRPATNSAVLKRPAEIRPGFVVRTADTGAPVCVLEANYDPIPRSFEHVRERDFNRILQYAYRVGCHAHLLFPDTRVHNGPVDIVYTGSPTGEDFHLGIYGVQFPDPIDSSITLDVSHIVHGILQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R193</accession>
    <name>A0A2Z5R193_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron-siderophore ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_10850</name>
        <name evidence="3" type="ORF">RA11412_2149</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88448">
        <property type="protein sequence ID" value="BAV88448"/>
        <property type="gene ID" value="RA11412_2149"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2149"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="70"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="347" mass="37094" checksum="10C09F8835DBA9FF" modified="2018-10-10" version="1">MSFEKNEVSGESIINRRNFMGLALASGAAFTLAACSGESTSSSTSGGSGETRKVQDVDEEEINIPVKPQRVVTLSEPTLDAALALGINPVGTVSGRGQSTVPNYLKEKAKDVPLIGTVAQVNYEKIDALEPDLILVDYTGVDKRSDAYSTLTKIAPVVYCGYAGGDWHFNFRNVADALNLKDKGEEFIKNYEALAAKTKEELAPKYGDKTFSIVRWAGNGPALILKELPAGQVLEDLGLKRPPAQDRKGQGHSDPVSLENLANIDADYMFLGTLGGASQQNPEAQGNAGLEGAEEALKKAKETSGFTELKAYKENHVKLVDGSKWTSTGGPLLMQGIIEDVKKDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1A0</accession>
    <name>A0A2Z5R1A0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="2">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_1972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88271">
        <property type="protein sequence ID" value="BAV88271"/>
        <property type="gene ID" value="RA11412_1972"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1972"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="85" mass="9214" checksum="C61B720F6A5077B9" modified="2018-10-10" version="1">MADYVGLEYSDYVITEAGFGADMGAERLFNVKCRISGLKPDAAVLVVTVRALKSHSGLYKIVPGKPLPDGMLQESPQMLRQGLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1E1</accession>
    <name>A0A2Z5R1E1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88557">
        <property type="protein sequence ID" value="BAV88557"/>
        <property type="gene ID" value="RA11412_2258"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2258"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="40" mass="4876" checksum="A6CA948717B6261E" modified="2018-10-10" version="1">MIFILLVTLILLFYEPFVTGKFLRYQVIWQIWHFDASSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1G0</accession>
    <name>A0A2Z5R1G0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyuridine-triphosphate nucleotidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88493">
        <property type="protein sequence ID" value="BAV88493"/>
        <property type="gene ID" value="RA11412_2194"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2194"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="65" mass="7233" checksum="7DC2DF08CA500B47" modified="2018-10-10" version="1">MDSGYRGEIMVTLLNTDPTKPFQIKRGDRIAQLVIQRYEQANFVVVAELDETERGVSGFGSSGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1I1</accession>
    <name>A0A2Z5R1I1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloalkane dehalogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88376">
        <property type="protein sequence ID" value="BAV88376"/>
        <property type="gene ID" value="RA11412_2077"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2077"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="448" mass="46483" checksum="58ED373BDFCFC0C3" modified="2018-10-10" version="1">MVDMDTKGDGTQVAVQLTWEQLADRVDAAAAQLHELGVRPGDRVNLMVPPGSRLTTLIYACLKLGAVIVVADTGLGLKGLTRALKGANPQFIVGIPAALAAARSLLWPGQRISVEPLNAFQERLLGVSGSVFAVAQKNQTGTVEFPAPAPDADAAVLYTSGSTGPAKGVVYTQRQLAGMRDAIAHTYGFEEGSALVAGFAPFALLGPALGATSVTPKMDVTKPKTLTATALASAAEAIDASTVFASPAALVNVVATAKELTEPQRSALAKVTTVLSAGAPIPVPLLQVLSQLVPNASLHTPYGMTEGLPVTDVSFEMIQQAISEGAPNSQGDVLDPFAKDGVCVGYPVYGAAVAIAALQDDGTPATETTRKPGVTGEILVSAPHVKDRYDTLWVTEEESISTPAGTTPVMLGIWTLPAVCGLRGGWRMCFSPLRVCSPRWLLSSPQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1J0</accession>
    <name>A0A2Z5R1J0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Alpha-acetolactate decarboxylase</fullName>
            <ecNumber evidence="4 9">4.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">budA</name>
        <name evidence="11" type="ORF">I6I94_10475</name>
        <name evidence="10" type="ORF">RA11412_2249</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:21580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15686"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="4.1.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Polyol metabolism; (R,R)-butane-2,3-diol biosynthesis; (R,R)-butane-2,3-diol from pyruvate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-acetolactate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.5" evidence="4 9"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88548">
        <property type="protein sequence ID" value="BAV88548"/>
        <property type="gene ID" value="RA11412_2249"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2249"/>
    <dbReference type="UniPathway" id="UPA00626">
        <property type="reaction ID" value="UER00678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047605">
        <property type="term" value="F:acetolactate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045151">
        <property type="term" value="P:acetoin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17299">
        <property type="entry name" value="acetolactate_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005128">
        <property type="entry name" value="Acetolactate_a_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524">
        <property type="entry name" value="PTHR35524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03306">
        <property type="entry name" value="AAL_decarboxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001332">
        <property type="entry name" value="Acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01252">
        <property type="entry name" value="acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0005">Acetoin biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT88926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="249" mass="27607" checksum="B789EE08F65EAC6C" modified="2018-10-10" version="1">MAYQPTRLNGETVFRNEVFQTGLMSQLLDGVYDGEMTIGELLSHGNFGVGTFNGLDGEMVVLDGACYQVRHDGSVSVPDLTGQTPYAVVTNFVPMIKRELPQNMLRKSTAQVLDNFTVSKNYMYAIKIYGEFEWVRTRTVVKQEKPYPKMVAATENEDIVQFDNLSGTIVGFRTPIYEQGISVPGCHAHFIDDDRTHGGHVVDFKLKSAQVEICPGTGLQLHLPLTAEFSSANLSPEDLADQISKAEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1U3</accession>
    <name>A0A2Z5R1U3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Enterobactin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Fes family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88441">
        <property type="protein sequence ID" value="BAV88441"/>
        <property type="gene ID" value="RA11412_2142"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2142"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008849">
        <property type="term" value="F:enterochelin esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021764">
        <property type="entry name" value="Enterochelin_esterase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11806">
        <property type="entry name" value="DUF3327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3327" evidence="4">
        <location>
            <begin position="15"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="361" mass="41025" checksum="D604495C2EEA2423" modified="2018-10-10" version="1">MHNPDGTVNEGERIVTFLYRHAEAQQVLIFVNRLTDEKNLPLSLMERIEGTDWWQLSFQMATNWRASYSFVPALPGERPVWLSESDQVMLRAALDAGEGDPFNPKTVCNRIGRCMGVVELKDAPVHEFLLSQQELDTLPAPRWLKTPDGHMYVVGKVGNPAPEDPLFILFDGEVWFNHGMEHTLNRAYRAGRIPPFHVFFLHSGGRERRWQELNGEHPIADYIVDEALPHLAKFHNIRTPAENIIINGQSLGGLSSLLAVISRPEAFGAAIAQSASLWQPQVFDRLEQLRSADELHRLRHLHLEVEVGEQEWVLVPPHQRLVQELKGVDMHLNYTVFNGGHDYACWRGAIVPALERILTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1W5</accession>
    <name>A0A2Z5R1W5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88735">
        <property type="protein sequence ID" value="BAV88735"/>
        <property type="gene ID" value="RA11412_2436"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2436"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="55" mass="6379" checksum="CF2EDF09B8F44FB6" modified="2018-10-10" version="1">MRWFIEKRKLWGRGLSAVDVYLLASVVVVPGTTLWTRDKRLRDVAQDLGCRFENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1X8</accession>
    <name>A0A2Z5R1X8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88612">
        <property type="protein sequence ID" value="BAV88612"/>
        <property type="gene ID" value="RA11412_2313"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2313"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="256" mass="27586" checksum="E679ED4AB6269740" modified="2018-10-10" version="1">MSGFGVSTAQAQPVFNASLDPKRPVIDKSGALDNLASGLKNELTQQLARANNLHAKGASSGKEYSIFMVVVNGTDSLTPQQWGKEFLSHNHAPTPSVVLVIDSSQQRGGIASNDQAFLTDKGADLLYVQNNTDIRNSPNPELAIRFHVGEGYYGSAGRQFASLLWNFQGLQSDNEIPDSVTAEANDFTNGNNTVQVLIIVLIVIAAVVMIAVVITVIFLLRRQKKHDLLLSQTHAEKMPQGIPPASASDPHQNSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Y0</accession>
    <name>A0A2Z5R1Y0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylamine N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_05695</name>
        <name evidence="4" type="ORF">RA11412_0600</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86899">
        <property type="protein sequence ID" value="BAV86899"/>
        <property type="gene ID" value="RA11412_0600"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0600"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="PTHR11786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="293" mass="32534" checksum="8D7B18C6CBA8B6FD" modified="2018-10-10" version="1">MDAAQFGEYLHLIGFKPTRCDLTALKTLLTRHMAALPFQTLSTVLGEPVPIDSGSIFRKLVAQRRGGYCYELNLLLLDALTLLGFEARPLTGSVIPNNRLEEAGARTHMLLQVTLQGQPWLVDAGFGGLAPTAPLLLESEKTQLTPHGQYRLKPHRDGLVLCAVTGAKQQLLYTFDRQPQRRIDLQVGNWFVSTHPHSPFRTRLMAARAVPDGSRHTLLNTRYTLHRPDGSRRVRTITDAASLLDVLRSCFTVSLPQTDGLSRRLQQFLDTHSDGDAGTQCTRGEGQVQEPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Y8</accession>
    <name>A0A2Z5R1Y8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88491">
        <property type="protein sequence ID" value="BAV88491"/>
        <property type="gene ID" value="RA11412_2192"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2192"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="153" mass="16408" checksum="6A0E91DCD50265BF" modified="2018-10-10" version="1">MVRVLSDRSGSQPPVGYPERFRVRLAGRIDQVWIPPLDAKPVYRAELVVAKSRLLQRVSPLAVLGIPLVVEPPGEDIDDSSNTPASKAVSGPLGAKAPTETSELAAFARTPPFEPGSRVSLIWHGQRSVPGCWPVHYCAARGCSASTRGPAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R234</accession>
    <name>A0A2Z5R234_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88604">
        <property type="protein sequence ID" value="BAV88604"/>
        <property type="gene ID" value="RA11412_2305"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2305"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="422" mass="44649" checksum="1CE30D1569C22565" modified="2018-10-10" version="1">MSTPGPTCRIPQRAEPPARLLLPGEYRAPEPTQENAWDVANSGQHTFVQASGLGPFPTADMVDALHRVRGELGDPHLPFLPELPHRGWRATTLARTIATFDGLHAEGASYGWRLTHTGTASRESALAYATYESDINALADVVGQENSRGGRSNGNASGGEPIFKIQLTGVYTLAASIYLPSGERAISDPGATRDIHESLFAGLRDRLETLRQALDTPDGRIAVQLNEPDLHRIIAGSIPTVSGFRRIRSIPAPTVMEGLRACAEAITDCGASPVLNLLGNTLNGSHIPAATGQKGLNLLELAQTIGGEDTPAALMIDPDAVSDTTILVPPLSDPRRFEIVAALIDAGARVWLPAIGDTPVPHQVRAFWRVWGELGLGGSQLAHVVLTERAETAGNLSRDVAEATAAMARTAEAAQALAELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R236</accession>
    <name>A0A2Z5R236_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_10525</name>
        <name evidence="4" type="ORF">NCTC10207_01494</name>
        <name evidence="2" type="ORF">RA11412_2237</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037234981.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88536">
        <property type="protein sequence ID" value="BAV88536"/>
        <property type="gene ID" value="RA11412_2237"/>
    </dbReference>
    <dbReference type="GeneID" id="32322799"/>
    <dbReference type="KEGG" id="raj:RA11412_2237"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI23387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="115" mass="11973" checksum="55CE7896A3CF6AE7" modified="2018-10-10" version="1">MHILTGVLVFLHIIGASLIIGLWVAHFRTPKVLPGQFHASLLMLVTGLILVGIAEMSGGVNHIKIAVKILLALGVAIAAFIGQRKHKAGEPISTGLAHAVGGLAVINVAVATIWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R276</accession>
    <name>A0A2Z5R276_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamyl-tRNA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88660">
        <property type="protein sequence ID" value="BAV88660"/>
        <property type="gene ID" value="RA11412_2361"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2361"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="1">
        <location>
            <begin position="108"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="227" mass="24099" checksum="F70B76D5628A2D46" modified="2018-10-10" version="1">MSELIFAHIATQAGLAQEIVSSSFEVYSDLESAEHLFTVASGLESAVVGEREIAGQVRRALATAQQASPVPGELVQLFEHAAHTARQVGQHTTIGSQGRSIVAVALDLADTVAEKDWANRRALIFGTGAYAGATIAALRERGCEDIWVNSRSGRAQQFAAKRDVHAVPQGHSWQAMAEADVIIGCSGGAAPLPPSDIPPVGTPSLIWRSLAISTPQWRTCPRWSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R283</accession>
    <name>A0A2Z5R283_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsS</name>
        <name evidence="8" type="ORF">I6I94_09115</name>
        <name evidence="9" type="ORF">NCTC10207_01778</name>
        <name evidence="7" type="ORF">RA11412_2566</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004005282.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88865">
        <property type="protein sequence ID" value="BAV88865"/>
        <property type="gene ID" value="RA11412_2566"/>
    </dbReference>
    <dbReference type="GeneID" id="29742581"/>
    <dbReference type="GeneID" id="61436371"/>
    <dbReference type="KEGG" id="raj:RA11412_2566"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VEI23869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="93" mass="10729" checksum="C19DC479DDB80215" modified="2018-10-10" version="1">MPRSLKKGPFVDQHLYLKVAAQNEKGTKNVIKTWSRRSMIIPDMLGHTIAVYDGRKHVPVFITESMVGHKLGEFAPTRTFRSHVKDDRKGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R287</accession>
    <name>A0A2Z5R287_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TsaB protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">tRNA (Adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tsaB</name>
        <name evidence="4" type="ORF">I6I94_09330</name>
        <name evidence="3" type="ORF">RA11412_2514</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037234604.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88813">
        <property type="protein sequence ID" value="BAV88813"/>
        <property type="gene ID" value="RA11412_2514"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2514"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TsaD" evidence="2">
        <location>
            <begin position="39"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="286" mass="29434" checksum="ADC6224B45303233" modified="2018-10-10" version="1">MLVLALDSSATASVALARIDSDAPGASAEILASYESEDTRSHAEVMAPYAAQVLADTGLDGAAVDAVLTGTGPGPFTGLRAGIMTARTLGFAWNKPVYGLMSLTAIVERAFADGAFRDSLTAANNGMNRAAHETLVASDARRREIYCALFAVTENGYSLAAGPSVGPAHQTHAPASDPSDPAAPALGYGAGLYAEALTASGWNVLKDYAHLHPTAADLVKAAARCGVKNLSRDTQALYLRESDAKVPAAMLARTASAQPPHGQQNTGEPQKTRGQQPAPAAPAREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2E0</accession>
    <name>A0A2Z5R2E0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NCTC10207_01584</name>
        <name evidence="1" type="ORF">RA11412_2342</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">NCTC10207</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88641">
        <property type="protein sequence ID" value="BAV88641"/>
        <property type="gene ID" value="RA11412_2342"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2342"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VEI23506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <sequence length="44" mass="5143" checksum="9A5D9382F71E692D" modified="2018-10-10" version="1">MEAFENILECYTHNSTLVLKGFSAESSAWLEYFFREPRVRVLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2E7</accession>
    <name>A0A2Z5R2E7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88873">
        <property type="protein sequence ID" value="BAV88873"/>
        <property type="gene ID" value="RA11412_2574"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2574"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="5171" checksum="665A27713CC06288" modified="2018-10-10" version="1">MKAVDIDNASLWAVRDVRERLNWDSWARRLLQLVRYLNGQGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2E9</accession>
    <name>A0A2Z5R2E9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA:Cys-GlcN-Ins acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88935">
        <property type="protein sequence ID" value="BAV88935"/>
        <property type="gene ID" value="RA11412_2636"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2636"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="77" mass="8054" checksum="AE2D9987CBE5A029" modified="2018-10-10" version="1">MVGVSPSAQGGGLGRTLVLRGLAYLALAHDEHNVPLRSIELYVDADNTPAVALYESLGFAVATIDRMYAPARPASGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2G2</accession>
    <name>A0A2Z5R2G2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_08800</name>
        <name evidence="1" type="ORF">RA11412_2648</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88947">
        <property type="protein sequence ID" value="BAV88947"/>
        <property type="gene ID" value="RA11412_2648"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2648"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="172" mass="19567" checksum="FC49C211AF37A065" modified="2018-10-10" version="1">MDTADYDTGFTTEFTAWTVPPELAVYPWDDAHPADRLKPGVISVHTPGRGCYELYLDPMPRPDRPGVCRTHARSGKLYPLGEGERWAHDVSIEWHSPTDDDMAIIALGDTVFWDEHRNGVYTIAYIGRDMNLWWDVRDENPRRMAFIQAIVEALHRSMQASPTLSVPPKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2K1</accession>
    <name>A0A2Z5R2K1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Superfamily I DNA and RNA helicases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88780">
        <property type="protein sequence ID" value="BAV88780"/>
        <property type="gene ID" value="RA11412_2481"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2481"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="193" mass="21617" checksum="41C1951F118EBFA9" modified="2018-10-10" version="1">MNIAATLAGQGKSVLVVGEKRSTLADFTALLERNGIDSLRFDVLTDRDAEGQRAEFIQAIVRNETAAIPEEEETTAELLETRRRLHRHTEALLSHEPYWNITTYQALQTLAELTSRNEAPATGVRFSRRMLDRLLERENLAHDLTRLAELGAFTPAARTSPGTVPAWPTTRRPLTLTHWFSPSNPPCCLCGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2R9</accession>
    <name>A0A2Z5R2R9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88756">
        <property type="protein sequence ID" value="BAV88756"/>
        <property type="gene ID" value="RA11412_2457"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2457"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="196" mass="20863" checksum="9BF274D3AC0E4EA0" modified="2018-10-10" version="1">MIREALAMILDLEIDLEVVKQVGRGDEVLPAVRETRPDVALLDIEMPGATGIEAAAELARSGLRSQTGAPVRSLILTTFRRPGYLRRALEAGASGFVVKDGTASQLAQAVRRTAAGLRVVDSVLAEEAKWQGSSPLTGRETEVLRTAETAGSVKEIAGMLGLSSGTVRNHLSAAMAKIDAINRHEAVRIARDNGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2U6</accession>
    <name>A0A2Z5R2U6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpsJ</name>
        <name evidence="7" type="ORF">I6I94_09090</name>
        <name evidence="8" type="ORF">NCTC10207_01783</name>
        <name evidence="6" type="ORF">RA11412_2571</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004005287.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88870">
        <property type="protein sequence ID" value="BAV88870"/>
        <property type="gene ID" value="RA11412_2571"/>
    </dbReference>
    <dbReference type="GeneID" id="29742830"/>
    <dbReference type="GeneID" id="61436366"/>
    <dbReference type="KEGG" id="raj:RA11412_2571"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI23879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="102" mass="11516" checksum="3E3519052836A463" modified="2018-10-10" version="1">MAGQKIRIRLKSYDHEVIDSSARKIVETVKGAGATVVGPVPLPTEKNVYCVIRSPHKYKDSREHFEMRTHKRLIDVVDPTPKAVDALMRLDLPADVNIEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Z0</accession>
    <name>A0A2Z5R2Z0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87259">
        <property type="protein sequence ID" value="BAV87259"/>
        <property type="gene ID" value="RA11412_0960"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0960"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="417" mass="44257" checksum="B074EDC719A85F2C" modified="2018-10-10" version="1">MRMALGRGREARRDAAYAALTGGDLAGRLGAVYALVELADEWLGEASLPVGVRRGHVQGVINRLCAYLRSPLNTAADNGPAGESAGAQGRIQQAIVEEIHRRVQHPVASAEGASLAGAWSGFAFNFSGAVFVCTVNFTGSRWEHEVDFSDCIFMRDALFSCSTFAGTANFAHSTYRALADFSESLYQDAAYFGGCTWGGAANFSGCTFRAGAYFLGCRYGADTVFTGCSFAGTVVMMYSAYRGAFTATRCTFAGDADLSSSAYYGPASLRGCVFLADAWLGGGSWGGRTVFSGSVFEGAADFSGAAYLADAIFTDAVFVNCAPSLRGCVFSPHSVQEFTRTPEQGHPIVLEGGLPVGSHLLTPGQLARLAKLRQKVTQRREQLADKPVGSAAHRRAARRLEQAHEAFARWAHGLTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R302</accession>
    <name>A0A2Z5R302_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpmJ</name>
        <name evidence="7" type="ORF">I6I94_09225</name>
        <name evidence="8" type="ORF">NCTC10207_01756</name>
        <name evidence="6" type="ORF">RA11412_2542</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004005257.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88841">
        <property type="protein sequence ID" value="BAV88841"/>
        <property type="gene ID" value="RA11412_2542"/>
    </dbReference>
    <dbReference type="GeneID" id="29742980"/>
    <dbReference type="GeneID" id="61436393"/>
    <dbReference type="KEGG" id="raj:RA11412_2542"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI23828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="37" mass="4299" checksum="455C8135414F5BDD" modified="2018-10-10" version="1">MKVKPSVKPICDKCKVIRRHGVVMVICENPRHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R321</accession>
    <name>A0A2Z5R321_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88960">
        <property type="protein sequence ID" value="BAV88960"/>
        <property type="gene ID" value="RA11412_2661"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2661"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="306" mass="33620" checksum="325B8ADF00958CC5" modified="2018-10-10" version="1">MTNQQIPFSVLDLMPTRKDRTHHQTMRYTLEAAQAVERFGFNRYWVAEHHNAGSLLSSATVVVMAEIAAATERIRVGSGGIMLPNHAPYVVAEQFGTLEAFHPGRIDLGLGRAPGTDPMTAQALRRDDSAAMNFPAEVEEIQRYLGEPSPMRRVHAIPGQGSNVPLYILGSSTFGASLAAQLGLPFAFASHFAPAALTEAINLYRTNFTPSRVLSEPYVIVGAAAMLADTDEQARRLFTTMQQHFWVLFAAARSTPRRLRLWISCGALLRSSASILCSPRRSLGPLILRSGSSLTWWSAPARMRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R372</accession>
    <name>A0A2Z5R372_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89034">
        <property type="protein sequence ID" value="BAV89034"/>
        <property type="gene ID" value="RA11412_2735"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2735"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="46" mass="5188" checksum="757C39B8D64CFB08" modified="2018-10-10" version="1">MFYEGSSWSIVFRESPLPIAEPYGILINFCDSKIIGFEDISGSEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3S1</accession>
    <name>A0A2Z5R3S1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6 7">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rplS</name>
        <name evidence="9" type="ORF">I6I94_01710</name>
        <name evidence="10" type="ORF">NCTC10207_00948</name>
        <name evidence="8" type="ORF">RA11412_1610</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6 7">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887925.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87909">
        <property type="protein sequence ID" value="BAV87909"/>
        <property type="gene ID" value="RA11412_1610"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1610"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VEI22855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="115" mass="13269" checksum="7A6213784E077F9E" modified="2018-10-10" version="1">MQTLDFIDKKSLRDDIPEFAPGDTLNVHVNIVEGKNRRVQVFKGFVVGRQGAGVRETFTVRKISFGIGVERTFPVHSPVIEKIEVVSRGDVRRAKLYYMRNRHGKAARIREKREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3V0</accession>
    <name>A0A2Z5R3V0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6493 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88019">
        <property type="protein sequence ID" value="BAV88019"/>
        <property type="gene ID" value="RA11412_1720"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1720"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="2">
        <location>
            <begin position="4"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="409" mass="46552" checksum="BD6DEB6094C34AC9" modified="2018-10-10" version="1">MREKSAREYRNIEQFFRNDPVLLEREFWDAFTVEGVIAQSKWDPALQPEYRSPSFSALAQVMCETFPEIRPRFLDETLKGLLRDYSAHHVRHFYRAHAALQPTPQEITERFVLYLSVLGTAYSPVIAMAQDLLEQAVYELSDTQARELIEVSATVLTRTEKKVLRAQIRLLSSLLEVHPECTEQVSQTVQDAFKSMPLDLQDEAQKLINDPVRETPTHQDAAGSITVPDNTPKDCEPQGCLTPRPPIATDRELMECLAATFQGGDGTDIPRILEYLEHAESLEINDAEQKLLWETRNLLIESPSSIYTLSSPNIPYLAIAALIKSGQIQHADIAKIPIIPTWYTERLYLSDEHGNPVTVDEQTLKEHQSRPINVKATGTEIRLNERGPHMLLMEQLFSLILRIKTQKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R419</accession>
    <name>A0A2Z5R419_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_00415</name>
        <name evidence="1" type="ORF">RA11412_1920</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88219">
        <property type="protein sequence ID" value="BAV88219"/>
        <property type="gene ID" value="RA11412_1920"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1920"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="347" mass="36991" checksum="F7BFFC7103F719FE" modified="2018-10-10" version="1">MTPLNLLDSAAPPGGGDRALIWRELRWVERQPVLETEPLTAAAGEQHPSGERIRIPLTPGAFLGLRLLADTAGEHLRYCAGYFASGPSGENTNTPNTGAPRRVPCPEGARIRGGKQCERCAARDEFTALHAAHLHPGTLTPGMRAYAATPHRLYIATFPDGTSKVGTSSQASTPRRLDEQAPAVATYIAQAPDGLSVREAEDAVTRIGGVPQVKQTPSKYRAWLNPLPNSTIRSVHQETLKTAREALTHAQLRVPLTPLHEPWEPSPAMARPYAALRAGSPEPLGQFPSVLSTGAAGFYCTGAAGKFMTAHTGDPAAALLVNTAEIDNLAFTVNHDISTVNIQTALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4L3</accession>
    <name>A0A2Z5R4L3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88649">
        <property type="protein sequence ID" value="BAV88649"/>
        <property type="gene ID" value="RA11412_2350"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2350"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="160" mass="18382" checksum="6589EC6D249B20C6" modified="2018-10-10" version="1">MGDMAVLLTLATVLGAIGVFWHYRHYTVFLPDQILISRVFGSAKILYYQQLEFFRIIPTDPDAIHPDMQDPSKWRIEVKIPGKSAPFSTSLSDPGVRYLIRQIAFRIEQERWADMNSPADREQLLQYHNDGRIICTTKGHKPAGEFAQEAAYRASFKQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4S0</accession>
    <name>A0A2Z5R4S0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09455</name>
        <name evidence="2" type="ORF">RA11412_2490</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88789">
        <property type="protein sequence ID" value="BAV88789"/>
        <property type="gene ID" value="RA11412_2490"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2490"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="281" mass="31183" checksum="9C850BA404163507" modified="2018-10-10" version="1">MNRISTHFLDFEGIKTAYYSTEGEGTPIMLLHGGGVDHAMLSWKTIMQTWTGSQPLVALDLPGYGNSDKPELEYSLSFYTGFLNAFLDTLNAQNVTLCGLSMGGAIALQYALRYPNYIGKLVLVAPWGVSASAPYSLMGRLLVRLPLNQATYKTLQNRWLAKNIIAGSLIGNREKITPEILDEVQTAAHSKDAARVFQSFQISELWGEPPVGHLIPLLPQIKVPTLFIQGDKDPGVKVGDVKQAAASMPNTRVEIFEHHKHWVQKESPERFVDIVRDFIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4T6</accession>
    <name>A0A2Z5R4T6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rpmD</name>
        <name evidence="9" type="ORF">I6I94_09190</name>
        <name evidence="10" type="ORF">NCTC10207_01763</name>
        <name evidence="8" type="ORF">RA11412_2550</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004005265.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88849">
        <property type="protein sequence ID" value="BAV88849"/>
        <property type="gene ID" value="RA11412_2550"/>
    </dbReference>
    <dbReference type="GeneID" id="29742512"/>
    <dbReference type="GeneID" id="61436386"/>
    <dbReference type="KEGG" id="raj:RA11412_2550"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_L30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="7">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VEI23839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="68" mass="7559" checksum="2E078CB077E43FE1" modified="2018-10-10" version="1">MAKRIQPSDAKLEITQVKSYVGQKQNMRDTLRSLGLKRPGNKVVRTADPVTVGMVNTVAHLVKVEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVD4</accession>
    <name>A0A2Z5QVD4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malonic semialdehyde reductase</fullName>
            <ecNumber evidence="3">1.1.1.298</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07985</name>
        <name evidence="2" type="ORF">RA11412_0043</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.298" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887607.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86342">
        <property type="protein sequence ID" value="BAV86342"/>
        <property type="gene ID" value="RA11412_0043"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0043"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="212" mass="23931" checksum="870683067D2D2663" modified="2018-10-10" version="1">MPPHYHDTINLANPTHRPRLEEEQRAALYLQPRTCYRFSEDPVTEEQLREIHQLTVMGPTAYNNQPLRITWVRSPHAKERLLTHLHEGNRASASQAPVNAILAFERNWQKRFTEFAPHAVAAQKFFEDEGERIPLGRLCAQVQAGYFITAVRALGLDAGPITGADFEAIAADAVLLGGQDQQPFLVVNIGYGLGPFRERGVRFSFEQTTRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVK2</accession>
    <name>A0A2Z5QVK2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86410">
        <property type="protein sequence ID" value="BAV86410"/>
        <property type="gene ID" value="RA11412_0111"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0111"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="189" mass="19531" checksum="31D79293787021CB" modified="2018-10-10" version="1">MEERAAHDQATGRGSRVFLHVAVAISLLMGVYLFAWVLPGYGRLAGAPVPELSLALSTDALGSFAHGLSSSSAGDALGPYTYAHRSVGLAFAVFFGLSVAGLSWAATAKKPLRVLLTALPLVYSAVFTATIFAVDASLADPAHQPGALVVLLPLGWALLVLSLLSLAYRGVRAFKRAVAAFIAGGPPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVK6</accession>
    <name>A0A2Z5QVK6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6318 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_07720</name>
        <name evidence="4" type="ORF">RA11412_0112</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887631.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86411">
        <property type="protein sequence ID" value="BAV86411"/>
        <property type="gene ID" value="RA11412_0112"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0112"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046281">
        <property type="entry name" value="DUF6318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19843">
        <property type="entry name" value="DUF6318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340084" description="DUF6318 domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6318" evidence="3">
        <location>
            <begin position="81"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="246" mass="27104" checksum="11FCE87F12757A75" modified="2018-10-10" version="1">MSSIFNRRAALGVLGASAGAFVLAACDANRSVSKGSSSSSNEPSETSPSASSATAQTDIDMSGDYKGKINFESVLEYKKSGTYEPATEEHAARNVPRPKKPEDANDKSLKGLYLSVVFAAAATQYAYNTGDYSLAEESALSESERDNYKGLEKVRLKKIREGNYWPDNVTIEYEITEPQPLLEDDRYLWSRTFKITYGKFEVEDGRVIYPKSGKGSVVAEEFIGLVSAQYVNGAWEISSHDNRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVK7</accession>
    <name>A0A2Z5QVK7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">sucC</name>
        <name evidence="10" type="ORF">I6I94_07740</name>
        <name evidence="9" type="ORF">RA11412_0107</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86406">
        <property type="protein sequence ID" value="BAV86406"/>
        <property type="gene ID" value="RA11412_0107"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0107"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="318"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT88423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="388" mass="40790" checksum="4CC57108EC0E44F3" modified="2018-10-10" version="1">MDLFEYQARDLFAKHGVPVLKGIVATTPEEAKAAAEEIGGLTVIKAQVKTGGRGKAGGVKLAKNPDEAYEHAQQILGMDIKGHTVHRVLVAQGADIAEEYYFSILLDRANRSYLAMCSVEGGMEIEQLAAERPEALAKVEVDPLVGIDSAKAQEIVEAAGFSAELQPKVVEVLAKLGGVFKKEDATLVEVNPLVQTPEGDILALDGKVSLDDNAEFRQPDHVALVDKSAENPLEAKAKQHDLNYVKLDGEVGVVGNGAGLVMSTLDVVAYAGEKHGNVKPANFLDIGGGASAEVMAAGLEIILGDEQVKSVFVNVFGGITSCDAVAEGIVKALEILGDSATKPLVVRLDGNNVEEGRRILSEANHPLVVQATTMDSGADKAAELANKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVT2</accession>
    <name>A0A2Z5QVT2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">VIT1/CCC1 transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_07750</name>
        <name evidence="7" type="ORF">RA11412_0105</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86404">
        <property type="protein sequence ID" value="BAV86404"/>
        <property type="gene ID" value="RA11412_0105"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0105"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01044">
        <property type="entry name" value="Ferritin_CCC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039376">
        <property type="entry name" value="Ferritin_CCC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV86404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="433" mass="46619" checksum="2AF1848271A11898" modified="2018-10-10" version="1">MSPEPRKHTPEAPSSNNHSPAQATPGRNRREPITTQAFTAPDVPTRRNPEHSAPSPTAARTGALDHVPARHHPVTQPSEAQIRRWRRYLADEESEARIYRYLAQRAEGKDREILMQVAEAEKRHQQHWRDMLGEHVGKPVRPSLSSAFLQFMAKHFGSVFILAMAQMAESRSPYAEDPDATEEMAADEAIHEEIIRALATSGREKLSGNFRAAVFGANDGLVSNLALTIGITASGASSSMVLLSGIAGLLAGALSMAAGEFVSVRSQRELLDASQPTQVTLRVAGDLDIDANELELIYRARGMDEEAAHHRALERFGYLDCDCDPSLSHRANEDGEEENVALGTDIGAAAASFSFFASGALVPILPYIFGLSGLWAMLLSLLFVTMALGFTGGIVGLLSGSSPMRRGLRQILIGLGAAGITYLLGLAFGTTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVV8</accession>
    <name>A0A2Z5QVV8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86537">
        <property type="protein sequence ID" value="BAV86537"/>
        <property type="gene ID" value="RA11412_0238"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0238"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="45" mass="5401" checksum="FD032BC2444A1643" modified="2018-10-10" version="1">MDAIQIFVIFEGYGDYNMNNLKILGWDKNQKTLYRYIKEGDTFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW22</accession>
    <name>A0A2Z5QW22_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86533">
        <property type="protein sequence ID" value="BAV86533"/>
        <property type="gene ID" value="RA11412_0234"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0234"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="80" mass="8592" checksum="29D91DBEC0D260A6" modified="2018-10-10" version="1">MEVKADGTWREVDSYGTYYGTADGKVYQERPGQEKHEVSKESTPTSTPVPPVLYAPGGVGGNSVIPLKPRTPLKAGEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW52</accession>
    <name>A0A2Z5QW52_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06805</name>
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    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86616">
        <property type="protein sequence ID" value="BAV86616"/>
        <property type="gene ID" value="RA11412_0317"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0317"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
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        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="22"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="333" mass="36463" checksum="A36F3F9D00E59D12" modified="2018-10-10" version="1">MERIESPAYARLGNSGLVVPSVGIGCNNLGRPGTPTQTQEGTNAVIAAAVEAGIGFFDIADLYGAEPGLSETMFGTAMRELNLNRDDLIIVTKFGLPTGTLNGNDWDARGSRRYIMRAVEGSLRRLGTEYIDLYFYHSPDQNTPLEETLSALDTLVTSGKVRYLGHSNFAGWQLAHAEHLARELGTERFIAAENHYNLLDRRAELEILPAARHFGLGVLPYFPLANGLLTGKYRRDSIPAGSRLSHSKAQVLAQADWEQLDAYREFCADLGISEVQASISWLKQQNPVASVIAGATTPDQVRANAQSASVRFNDDELARLNEIFPAPERIALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW82</accession>
    <name>A0A2Z5QW82_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin VbhA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_06720</name>
        <name evidence="1" type="ORF">RA11412_0341</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86640">
        <property type="protein sequence ID" value="BAV86640"/>
        <property type="gene ID" value="RA11412_0341"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0341"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of protein adenylylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="VbhA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033788">
        <property type="entry name" value="VbhA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043038">
        <property type="entry name" value="VbhA_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="67" mass="7389" checksum="605EBFBCF762BE97" modified="2018-10-10" version="1">MTEKKPTQQQPTEKEVQESIAFAVAAANLAGCTPPTTEELERLERVARGEITTDEAIAEIRHRIQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWA0</accession>
    <name>A0A2Z5QWA0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86662">
        <property type="protein sequence ID" value="BAV86662"/>
        <property type="gene ID" value="RA11412_0363"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0363"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="46" mass="4945" checksum="1FCF2F5571E70DB9" modified="2018-10-10" version="1">MEGGAPEVPGSWDDLDTAEVHKLIDDDFFNEVADQIDAKAQATPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWA8</accession>
    <name>A0A2Z5QWA8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86688">
        <property type="protein sequence ID" value="BAV86688"/>
        <property type="gene ID" value="RA11412_0389"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0389"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016248066" evidence="1">
        <location>
            <begin position="42"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="184" mass="19859" checksum="CC15BEEB1A29B838" modified="2018-10-10" version="1">MPTDNTGLSRRKLLRTTAIGVPAAGLLAFGSTLVTATSANAVEVDGWWGPETSAGVQRLMIAMFPKDQEVFPVAVDGVISSQPSFMAPYCPGIVGGWEWVDRGHAEGSTTITRMHEWLHKYHEGLTWANTHWIGDSLITALHRHYGYTSVTEVSAKKYGLKPGTLPGGGGVIKGLQNEINQWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWJ9</accession>
    <name>A0A2Z5QWJ9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable low-affinity inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_0489</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86788">
        <property type="protein sequence ID" value="BAV86788"/>
        <property type="gene ID" value="RA11412_0489"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0489"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV86788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="263" mass="27265" checksum="BEACC5C3B0802E39" modified="2018-10-10" version="1">MTTELIILVIVVLTALAFDFTNGFHDTGNAMATSIATGALKPKTAVALSASLNLVGAFLSVEVAKTVGKGLVDLDQIDIKKDGSALMLIVFTGLVGGILWNVLTWLLGLPSSSSHALFGGLIGSALAALGFSGVQWGGVLSKIVIPAVMSPLVAALVSTVGTWLVYRIASPVSDERKTRGFRWGQVGTASLMSLAHGTNDAQKTMGVIFLALVASGSVNDNDAIPFWVKASCAIAIALGTYLGGWRIIRTLGKGIVEVDTPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWK0</accession>
    <name>A0A2Z5QWK0_9MICC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_06015</name>
        <name evidence="3" type="ORF">RA11412_0506</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037237213.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86805">
        <property type="protein sequence ID" value="BAV86805"/>
        <property type="gene ID" value="RA11412_0506"/>
    </dbReference>
    <dbReference type="GeneID" id="32322061"/>
    <dbReference type="KEGG" id="raj:RA11412_0506"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="134" mass="14562" checksum="3049FDD82F505404" modified="2018-10-10" version="1">MDFKNLSPAYLSSLGAVLVSALMIGSGVSWMLWVGWLLLLLAVGLNVFAHLVTVSKMKGEPAPAMLTNLEQRFEAMREKAAERSEEPIEGEPDFDGDPLDSEATVELGSETPKKKSVLPSKIEDSQSSSRPTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWP3</accession>
    <name>A0A2Z5QWP3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86847">
        <property type="protein sequence ID" value="BAV86847"/>
        <property type="gene ID" value="RA11412_0548"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0548"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="5133" checksum="BFEA1009FCEF1391" modified="2018-10-10" version="1">MFDPKNQHRTHTVTSKLSTRFLHATHKWRASLWMPAVSEEAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWV1</accession>
    <name>A0A2Z5QWV1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Quinolone resistance protein norA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_0561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="BAV86860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86860">
        <property type="protein sequence ID" value="BAV86860"/>
        <property type="gene ID" value="RA11412_0561"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0561"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV86860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="206" mass="21675" checksum="D60AA7F8491F7DEB" modified="2018-10-10" version="1">MALAMIAAGFDFYVPVSAFFLESRGLSLTDIFMLESVLVASILVAEIPAGVIGDRFDRRRLVGAGFVFNAIAEILFATGTNFSIYALSFVMSGLSIAMLTGVQDAYIYDSLGDDADAKAVGAWGHLSALMLTAGVTGSVVGSALGSVDISLPALLSAAMAVVAAVCVAFLPQQNPKTHDKHPETSWVSLKIGVKLLLPHRFCCTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWV3</accession>
    <name>A0A2Z5QWV3_9MICC</name>
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        <submittedName>
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        </submittedName>
        <submittedName>
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        </submittedName>
        <submittedName>
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        </submittedName>
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    <gene>
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        <name evidence="4" type="ORF">NCTC10207_00110</name>
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        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Rothia</taxon>
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    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888480.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86917">
        <property type="protein sequence ID" value="BAV86917"/>
        <property type="gene ID" value="RA11412_0618"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0618"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
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    <dbReference type="Pfam" id="PF00581">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="12"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI22044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="109" mass="11907" checksum="C4C9B6C4AF14919C" modified="2018-10-10" version="1">MSDVPQVNPTNVPAGATIIDVREDYEWEAGHVAGAQHLVLNELPERLDELPKGEDFYVICHGGGRSNRAAEYMRENGYQANNIAGGTTAWFEANLPMDSENGKDPAVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWW5</accession>
    <name>A0A2Z5QWW5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homoprotocatechuate degradation operon regulator, HpaR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06430</name>
        <name evidence="4" type="ORF">NCTC10207_02366</name>
        <name evidence="2" type="ORF">RA11412_0415</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT88185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI25009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86714">
        <property type="protein sequence ID" value="BAV86714"/>
        <property type="gene ID" value="RA11412_0415"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0415"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI25009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="172" mass="19641" checksum="A5894DAFBDF77A30" modified="2018-10-10" version="1">MSDSPHAEEPRWLTPEEREAWLFISSIIFNLTRRLENQLQREADLSYVEYMVLAMLSESPELSLTMTELALTTNTLPARLSRVVARLEKDSLVERSISREDRRVSICHLLPAGLERIQQVAPGHVAEVRRQIFDHLNEQQVYDLANIGTSVLGDTPSKLISIDSLRRGSYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWY4</accession>
    <name>A0A2Z5QWY4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_05565</name>
        <name evidence="1" type="ORF">RA11412_0633</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86932">
        <property type="protein sequence ID" value="BAV86932"/>
        <property type="gene ID" value="RA11412_0633"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0633"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="102" mass="11553" checksum="018EA4CFD0D2126B" modified="2018-10-10" version="1">MGTQDSNTQPPSPLHHKLNTVQARIDAHVFGSGPMAQSLAIIEKMRAEGATDHEIDTTLHKKKLPSVVDVGRKSVLHLPSWWWLNRRKKSLENKISKRAKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX38</accession>
    <name>A0A2Z5QX38_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0604</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86903">
        <property type="protein sequence ID" value="BAV86903"/>
        <property type="gene ID" value="RA11412_0604"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0604"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="8">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="30"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="374" mass="40770" checksum="AD80E51324307936" modified="2018-10-10" version="1">MWLPEQVGASVGKKGETVKQQDVVLYGFGRIGRLLARILLERSSSLGANLRLRAVVVRKNTENDLEKRASLLARDSVHGPFKGTIKVDAENDTIIANGLPVRFIYSSDPTTVDYTEYGIEDALLVDNTGRWRDVPGLTQHLERPGISRVLLTAPGKGDMKNIVFGVNDNIITDDDKILSAASCTTNAITPALKVLDDVYGVERGHVETVHAFTNDQNLIDNFHKGDRRGRSAVLNMVITETGAARAVSKALPQLEGKLTGNAIRVPTPDVSMAILNVKLAKPAGSKDELNEVFRQVALKGELRRQIGYSDSHEAVSTDFVGSRNAGVVDALATVVTDDSAILYVWYDNEFGYSCQVVRVLERLVGEEAPSYPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX48</accession>
    <name>A0A2Z5QX48_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone protein Lsr2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Lsr2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Lsr2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lsr2</name>
        <name evidence="4" type="ORF">I6I94_05165</name>
        <name evidence="5" type="ORF">NCTC10207_00202</name>
        <name evidence="3" type="ORF">RA11412_0718</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023133547.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87017">
        <property type="protein sequence ID" value="BAV87017"/>
        <property type="gene ID" value="RA11412_0718"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0718"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI22136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="120" mass="13106" checksum="BBEAE5955E1BAE79" modified="2018-10-10" version="1">MAQKVRIILEDDLDGGPADETVRFGLDGGQYEIDLSNANAARLRDAIRPFASKARRVQNTSGSGRAGRGSRGAATAVKRNPETAAIRKWAKENGHEVSDRGRIHQEIQDAYYAALKKEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX50</accession>
    <name>A0A2Z5QX50_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asp23/Gls24 family envelope stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05470</name>
        <name evidence="2" type="ORF">RA11412_0652</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86951">
        <property type="protein sequence ID" value="BAV86951"/>
        <property type="gene ID" value="RA11412_0652"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0652"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="134" mass="14446" checksum="8AD8DED838EC831D" modified="2018-10-10" version="1">MTETSTQPAAAGAESSWQEQRGVTVIPAQVVAQIAAQAAYESANVGSNAGGLLGIGARRNFHSRPEAKCDIYGQVAVLHLDIGLTFPTALVSTLQQLREHVSQRVEHFTGLKVEKINIEISWLNPSSQARRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX57</accession>
    <name>A0A2Z5QX57_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transmembrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_0728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87027">
        <property type="protein sequence ID" value="BAV87027"/>
        <property type="gene ID" value="RA11412_0728"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0728"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="137" mass="14165" checksum="A6986717F7AEA305" modified="2018-10-10" version="1">MIAVGMALMSIGLFWSGAILDPSVEYIHFVPPFMAAGVGMGMVFAPIATATLQGMAPEDRATASGTNMTVRQIGIALGIATLTAIFTALDGTLTPTGFTEAASPAILTGAAVMMLGTFAAFFLPKHVRVRAEEKVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX62</accession>
    <name>A0A2Z5QX62_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Di-/tripeptide transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_05615</name>
        <name evidence="6" type="ORF">RA11412_0617</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Membrane</location>
            <topology evidence="1 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86916">
        <property type="protein sequence ID" value="BAV86916"/>
        <property type="gene ID" value="RA11412_0617"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0617"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="487" mass="52865" checksum="9B46643AD57E3752" modified="2018-10-10" version="1">MSATAPVTEHQQHNRTFFGHPPMLASLFTVEMWERFSFYGMQALAIYYLYYSIDKGGLGIPEEAATGAMGAYGATVYLMAILGGILGDRVLGPERTLFYSAIGIMAGHIALAAIPGATGVLIGLLLVAIGSGCLKSSASVLVGSLYNKDDPKREAGFTLFYIGINIGALLGPALTGWGWGWLGFHFGFGIAAIGMAAGLIQYAFTRKNLPESVHEVTAPFTPRQNGILAGTLLSIALIIFLLVTMGWITTSNISTWVVSAVGIGAVALFVQLLTAKNVTSDERSRVWAFIPLWIANAIFWALYQQQFTFIPVYSEKRLDWHILGSDLPPTLVNSLAPIFVILLGSGFAAMWTKLGDRQPRTTTKFSLALVTIGPAYWVFLTQVGVPKVAVYWMVIIMFIFTVAELTISPTGMALTTRLAPETYKVNMMALYWTSLAMGNAFAGWCAQFYSQDTEVPYFTYVGAVSVIAGIVLFLCRAPVQKLMRGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX63</accession>
    <name>A0A2Z5QX63_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP-dependent Clp protease ATP-binding subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">ATP-dependent Clp protease ClpC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="16">Probable ATP-dependent Clp protease ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">clpC</name>
        <name evidence="15" type="ORF">I6I94_05160</name>
        <name evidence="16" type="ORF">NCTC10207_00203</name>
        <name evidence="14" type="ORF">RA11412_0719</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="15 19" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 19">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888502.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87018">
        <property type="protein sequence ID" value="BAV87018"/>
        <property type="gene ID" value="RA11412_0719"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0719"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="13">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="12">
        <location>
            <begin position="427"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="832"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="423"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV87018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QQT89980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VEI22137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="856" mass="94681" checksum="B59F9698076E2F22" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXG3</accession>
    <name>A0A2Z5QXG3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PS_pyruv_trans domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87033">
        <property type="protein sequence ID" value="BAV87033"/>
        <property type="gene ID" value="RA11412_0734"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0734"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="17"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="316" mass="34531" checksum="6A5EFDAB43F85ADE" modified="2018-10-10" version="1">MTKVLVAGDIGQPVYHVGDEAMTVASATFFAGRGARIVLATRDEEHSRQLIGAGTAGEEYEYLPYLLFPWAPAQREQTLELLEEYLRSSVMPTLPEFAPDATKIRAFVEGVCAVDAVVISGGGNLNSRYGWLLYERAAIALVAEYRKIPLFISGQSLGPVLSNTDAEVLERMLRSAVAVAVRERGSYAWCTERGIEALAGADDATDYAPHSPELTLEYPESVTVPELPQRYVCVTINDADDEQAQNLAELLEYTYQEHGLSTVFLSHMGNPAQAAVAGERGDYEVHARIAEQMHTPATLVPITHADAAVRIHRGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXM7</accession>
    <name>A0A2Z5QXM7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_04700</name>
        <name evidence="2" type="ORF">RA11412_0822</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87121">
        <property type="protein sequence ID" value="BAV87121"/>
        <property type="gene ID" value="RA11412_0822"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0822"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="1">
        <location>
            <begin position="103"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="317" mass="33730" checksum="3B5C4AA4F018B400" modified="2018-10-10" version="1">MKILLPTSITLDEEKLGLEPGDIVRHYNPTEPIAEEDTDAEVLIAWANTADQLADSARRMKNVGLIQALLAGPDAVRAAGFTPDAAICAGVGLHSKTVAEHALALTLNFVRFLPTLAQATVEHRWAEELGGAQELHPKDQVTTLLDANVLVWGFGSIGQETARLFKAFGANVTGVAQSAGERSGFPVIATEQIDEYLPTTDILVMVLPTSNSTFKALDAHKLQLLPKRAYLINVGRGTTVDEDALVAALNSGSIAGAALDVTATEPLPSDSPLWDAKNIVITPHAAGGRPVNPEELIAHNIRALRTGAAASEYRNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXQ0</accession>
    <name>A0A2Z5QXQ0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87235">
        <property type="protein sequence ID" value="BAV87235"/>
        <property type="gene ID" value="RA11412_0936"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0936"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="40"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="316" mass="34379" checksum="97943634769F9221" modified="2018-10-10" version="1">MGSNTVHLLLIDGHPGARPEPYASHKIPLQLVQYLTPSGDISDEGRAALTEFVKSARDFAIENNAEDLLAFATSAIREAGNGAEVLQHVRRKTGVSLSGISGDQEAAITYFAVRRWQGWGAGRILNFDIGGGSFEFSTGTDALPDAAMSVPLGAGRLTREFFEEQPPAPKQTKRLRGYVREQIEPVAQQLLAFGEPNMVVGTSKTFRSLARICGAAPYSAGPHVKREMHVTDLRLWTRRMEAMAPAERADLPGVSRMRADQVLAGAMVAEAAMEMFGVETMRVCPWALREGLILRRLEHLAEGTSTPLDPKTLVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXR3</accession>
    <name>A0A2Z5QXR3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_05135</name>
        <name evidence="3" type="ORF">RA11412_0725</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888602.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87024">
        <property type="protein sequence ID" value="BAV87024"/>
        <property type="gene ID" value="RA11412_0725"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0725"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="230" mass="23712" checksum="E8BAAD03CA9660E1" modified="2018-10-10" version="1">MSEDMDLPPEVYRRRRIIAAVAAIIILILLIVGITWAVNTIQNRNTNEAVPSATATAEAFQNFSARADVTASPTGSASANPSQAADPSKSPDPSASTTSAAVAACSAQNLKVTVAPSKKQYAAGEAPSFTVTYTNTSKTPCAIGGDKAENGIELNITSGAAQTYSKNKCAPAPLKKAELEPGKEATGEIAWDRKSNASGCEKTKDAEKGTYSVVASVNGVASQAVNFTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXY2</accession>
    <name>A0A2Z5QXY2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_04035</name>
        <name evidence="6" type="ORF">RA11412_1003</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87302">
        <property type="protein sequence ID" value="BAV87302"/>
        <property type="gene ID" value="RA11412_1003"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1003"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="881"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="1209"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="818"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="1370" mass="149809" checksum="9A41AD66C8D94C63" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY18</accession>
    <name>A0A2Z5QY18_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87251">
        <property type="protein sequence ID" value="BAV87251"/>
        <property type="gene ID" value="RA11412_0952"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0952"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="427" mass="46338" checksum="39A0EEDBAB1A0D65" modified="2018-10-10" version="1">MRPAAQYPESAQYPESAQPSGVQSVGVGRGQRRIAATGQLSSADADTRLAGALALIELADEWLTTPAADQITSKHPNPNQPAREAQAIIHELCAYIRSPFPAGSASSRTELAQYYMRLLGDAPEGLSRTQREQFQAEKSALAVEALVRGCILEAIHDRFVQESDYGTPPCTGGTPDLQEAEGSRWSGLDYDFSGAVFFYPVLLKASYCMGEMAFRDCIFLEEACFSHAYFAQCTDFSGAAYYGDASFGFSSFKGGARFDRCTFGALAEFTDTYYGGDALFRGAPIRGWPCMMSPPTAVRWLISVIVCIVRVPSSAVPGMTARPYSAGPFLRAPHILGLAGTLIRFVTMGAPTRLQPISAILSAGLMRIFQAPLLLREPVLPGVNIMVPRIFRAVLLLAVRSIILAPYMRQRCLLVTQCMARAPAPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY62</accession>
    <name>A0A2Z5QY62_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ccs1/ResB-related putative cytochrome C-type biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_0977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87276">
        <property type="protein sequence ID" value="BAV87276"/>
        <property type="gene ID" value="RA11412_0977"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0977"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="7">
        <location>
            <begin position="27"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="143" mass="16033" checksum="02FDC603558D2634" modified="2018-10-10" version="1">MARTHTDAPALGITGMLRWGWTQLTKMNTALLLLLLLAVAAVPGSMFPQRIQDPAKVTDYIKTHPGWGEFADKIQLFDVFSSGWFSAIYLLLFISLIGCVTPRAIKHAKDWRKPPARTPKNLSRMPVHRTIDIDADALTPRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY87</accession>
    <name>A0A2Z5QY87_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_1136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87435">
        <property type="protein sequence ID" value="BAV87435"/>
        <property type="gene ID" value="RA11412_1136"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1136"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="2"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="333" mass="35372" checksum="285E3994A171D025" modified="2018-10-10" version="1">MWTSNATEALNLIAYAIGNASQGIGGEKAEQFALGEGDEIVTTEVEHHANLIPWQILAQRTGATLRHIPVTSDGQLDYEAAEQIVGQNTRILAFTHVSNVTGAITDVPYMVALARKAGALTVLDACQSVPHMPVDFPGLGVDFAAFSGHKMLAPTGIGALYGRAELLDALPPFLTGGSMITRVGLEDAEYMPAPIKFEAGTQRVSQTVAFAAAVRYLEHVGMANVQAWEHELGQRLAAGVQQIEGVRLLGPADPARRAGLVSLAIDGVHPHDVGQLLDTWGIAVRVGHHCAQPLHKLSGVTASTRASAYLYNTTDDIEAFLAALAKVRPYFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYA5</accession>
    <name>A0A2Z5QYA5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Succinate dehydrogenase flavoprotein subunit</fullName>
            <ecNumber evidence="5 16">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">sdhA</name>
        <name evidence="21" type="ORF">I6I94_03930</name>
        <name evidence="22" type="ORF">NCTC10207_00484</name>
        <name evidence="20" type="ORF">RA11412_1027</name>
    </gene>
    <organism evidence="20 23">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 23" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 23">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="22 24" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 24">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="21 25" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 25">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a quinone + succinate = a quinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 16"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888069.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87326">
        <property type="protein sequence ID" value="BAV87326"/>
        <property type="gene ID" value="RA11412_1027"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1027"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 16" id="KW-0274">FAD</keyword>
    <keyword evidence="9 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0813">Transport</keyword>
    <keyword evidence="8 16" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="18">
        <location>
            <begin position="7"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="19">
        <location>
            <begin position="455"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="15">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="BAV87326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QQT89763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="VEI22409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="587" mass="65190" checksum="A1FD459E21570EE5" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYH9</accession>
    <name>A0A2Z5QYH9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87341">
        <property type="protein sequence ID" value="BAV87341"/>
        <property type="gene ID" value="RA11412_1042"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1042"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="77" mass="8054" checksum="CF06BED4DB093C19" modified="2018-10-10" version="1">MLLLGIGTRIAAAAITIAMAGAYIFVHVNAPFIIDPKTGAGFEYVFVLGMAAIMFILVGGGKYSIDALLPHRGTKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYJ8</accession>
    <name>A0A2Z5QYJ8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87361">
        <property type="protein sequence ID" value="BAV87361"/>
        <property type="gene ID" value="RA11412_1062"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1062"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="139" mass="15402" checksum="DBB37E5CD281DECE" modified="2018-10-10" version="1">MLGLLIMWLVVTCALIPAVIHELGHALALRYVAGVRHIRIESTPLRFSLLTPHEDLTPKSSLMVAVAGPVAAFIGGTVWQLMGHSFIAFWWYMHLIMLLPLFGDGKELVKAITAIRAPGHSWVSCAHLLMYKRKSPPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYR7</accession>
    <name>A0A2Z5QYR7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argR</name>
        <name evidence="12" type="ORF">RA11412_1316</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ArgR family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87615">
        <property type="protein sequence ID" value="BAV87615"/>
        <property type="gene ID" value="RA11412_1316"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1316"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="10">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="11">
        <location>
            <begin position="89"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV87615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="161" mass="17149" checksum="F3EFBCCD3233DE11" modified="2018-10-10" version="1">MPFPSTKIARQARIVELLQTRRVRSQAELAQYLIDDGMKVTQATLSRDLVEIGAEGIRDEGSGLIYAVPNYPARRGGGETPDARMISLFKELLITAEGSGNTTILRTPPGAAQFLASSIDQSGLEAILGTIAGDDTVMVVTRDPSGGQELAESFLAWSAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYS5</accession>
    <name>A0A2Z5QYS5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5-methyl-dCTP pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1303</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87602">
        <property type="protein sequence ID" value="BAV87602"/>
        <property type="gene ID" value="RA11412_1303"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1303"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="149" mass="16146" checksum="4F40C443104DD667" modified="2018-10-10" version="1">MMTHYPVQVVGAAIFDSLQSPTRLLVARRSAPEALAGLWEFPGGKVEPGESCEKALARELAEELGVQVQLGQELTGPHPQGWVLNNNAAMRVFFAELTLGEPHPLQDHSELRWLPLGSDHNVSAVLSLEWIPADYPIVEALLAAVHAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYS7</accession>
    <name>A0A2Z5QYS7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87625">
        <property type="protein sequence ID" value="BAV87625"/>
        <property type="gene ID" value="RA11412_1326"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1326"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="63" mass="6929" checksum="86B513D319AFCE64" modified="2018-10-10" version="1">MSEKSTGAELTLENGPETLLSDEERAEYEAFEEKLAAALALDPLERINAYGKLVEKLTAELES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYU5</accession>
    <name>A0A2Z5QYU5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_03370</name>
        <name evidence="5" type="ORF">RA11412_1181</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888052.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87480">
        <property type="protein sequence ID" value="BAV87480"/>
        <property type="gene ID" value="RA11412_1181"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1181"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340100" evidence="3">
        <location>
            <begin position="32"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="194"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="244" mass="23932" checksum="F279CC50107B3BE7" modified="2018-10-10" version="1">MKNTSTVRRTAAALAVGGAVAATMSVPAANAADSATWDALAQCESGGNWSINTGNGFYGGLQFTQQSWNGVGMAGSPNGASREQQIQAAERLLAVQGWGAWPACSAKLGLYGKAGASATAQNYEAPAAQSQVNTQAQAQESYTAPAAQAPATQAPAQQAPAAPAAAEAPAAQAPAAQAPAATYTAPAAPAAAAGTYTVQAGDTLSGIAAAYGVQGGYNAIAAANPGTIVNVDLIYPGQVLNIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYY7</accession>
    <name>A0A2Z5QYY7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03460</name>
        <name evidence="2" type="ORF">RA11412_1155</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888093.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87454">
        <property type="protein sequence ID" value="BAV87454"/>
        <property type="gene ID" value="RA11412_1155"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1155"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="90" mass="10085" checksum="55F110A4060DE1A0" modified="2018-10-10" version="1">MSEKKTVHTYSGQGKHLENAVLFIGCFVFLLLGLYLLGTYPDGLGILSEHDGWFWYAGALVCYGLFFGLVFHVLPSKTTRVIKDVNKVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ06</accession>
    <name>A0A2Z5QZ06_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87521">
        <property type="protein sequence ID" value="BAV87521"/>
        <property type="gene ID" value="RA11412_1222"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1222"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="173" mass="19838" checksum="188E82DB45EFC999" modified="2018-10-10" version="1">MEVDRLFTRLANDYEHLSSGAEVPSDIYTSRSIRQVIFQAEPGGYNPVEVDRALEQVGERFAKLERSRYIQRYGLTEWERSLRSTGELLAGRLERPRGEKFRRPTKRKTVGYFISDVDELCDRVLAQLNSEEPLDAGVVQRASFRPATGSVCYDETQVDAFLDRCIELLQDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ07</accession>
    <name>A0A2Z5QZ07_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87593">
        <property type="protein sequence ID" value="BAV87593"/>
        <property type="gene ID" value="RA11412_1294"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1294"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="89" mass="10192" checksum="F0AEA985BE488C41" modified="2018-10-10" version="1">MYYFDYAGYSIEFICGEDTYRPKGEQIEVYAPELVLDAALCSILTVEKFNLSPLKNAAIEEYSDGDEYVIFLRNGLNLYYLSNGEQSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ60</accession>
    <name>A0A2Z5QZ60_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="8">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisA</name>
        <name evidence="12" type="ORF">I6I94_02920</name>
        <name evidence="11" type="ORF">RA11412_1292</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87591">
        <property type="protein sequence ID" value="BAV87591"/>
        <property type="gene ID" value="RA11412_1292"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1292"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV87591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT89583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="277" mass="29484" checksum="996CE696C5B0670B" modified="2018-10-10" version="1">MHSQHLGKLQLLPAVDISEGRAVRPVGGQLLGTSQSIDPVAAAITWGEAGAEWIHLVDLDLAFGRGTNTSVLEQVIDEVRDRTSNRIKIQVSGGIKDHRSIELALSLRPDRINVTSAALAQPSWLEQVLEEHGELLALGVDVRDGVVVARGTDWRGDALDASIMWLERAGAQRYVVTDVSRDGALSGPGLEPLQHVLALTGKPVIASGGVASLNDIRVLRGMTAQGLEALVLGKALYTGRFTLEQALQVAHGTAEGVSVQEQLAWKPPTEQAESSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ61</accession>
    <name>A0A2Z5QZ61_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperone protein DnaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87656">
        <property type="protein sequence ID" value="BAV87656"/>
        <property type="gene ID" value="RA11412_1357"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1357"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="194" mass="20533" checksum="65E7EA88F97FE674" modified="2018-10-10" version="1">MGIAVGIDLGTTNSAVSVVRPTGKPEVLKNKEGDSITPSVVLFQSFGGPDEPLVGEQAKRQAAAFPDDIVQHVKRYMGDPSWRFDSSSGAQYSAEEVSAIILKRLKEDAEIALGEEVTDAVITVPAYFDDARRTATKQAGQIAGLNVLRVLNEPTAAALSYGIDADANGTVLVYDLGGGTFDVTILKLLVPNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ85</accession>
    <name>A0A2Z5QZ85_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 16" type="primary">atpA</name>
        <name evidence="15" type="ORF">I6I94_02170</name>
        <name evidence="16" type="ORF">NCTC10207_00857</name>
        <name evidence="14" type="ORF">RA11412_1473</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="15 19" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 19">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037288058.1">
        <property type="nucleotide sequence ID" value="NZ_JPVS01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87772">
        <property type="protein sequence ID" value="BAV87772"/>
        <property type="gene ID" value="RA11412_1473"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1473"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
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</entry>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
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    <accession>A0A2Z5QZF3</accession>
    <name>A0A2Z5QZF3_9MICC</name>
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        <submittedName>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    <name>A0A2Z5QZF8_9MICC</name>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87743">
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    </dbReference>
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    <dbReference type="Pfam" id="PF13787">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="138" mass="15376" checksum="9AEADFB7A9404AB7" modified="2018-10-10" version="1">MTISGFALITLVLFMVHEFEEIIFVRRYIDKHADNNRYHDELFVAGQDHYPSTAAIAAMIAEEFVVACLILCTGIILDSAEVVAAMFIAYTLHLVIHIREAIVFPGGRRAAGPQYLPCRLTLLPYTLSLLPSISITSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZG4</accession>
    <name>A0A2Z5QZG4_9MICC</name>
    <protein>
        <submittedName>
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    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87746">
        <property type="protein sequence ID" value="BAV87746"/>
        <property type="gene ID" value="RA11412_1447"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1447"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="213" mass="22687" checksum="70A76E8075147327" modified="2018-10-10" version="1">MEPVTINLEQATVRFGDKTALDNFTGEFTPGTVTALIGGDGAGKTTLLKLLAGRLRTHSGNNSGYAVDRHNVGYQPADSGVWRHLSVAENIEFVARTYGLSPDKARTRSEELLTKAGLDHVPNRLAGRLSGGMRQKLGVVLATLHQPGLVLLDEPTTGVDPISRAELWSLIAATAAEGATVIFATTYLDEAERATRLFLLDHGTLLGVGTPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZH0</accession>
    <name>A0A2Z5QZH0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87691">
        <property type="protein sequence ID" value="BAV87691"/>
        <property type="gene ID" value="RA11412_1392"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1392"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transpeptidase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="230" mass="25018" checksum="0678C5D1E088A317" modified="2018-10-10" version="1">MNTGTVLVGQKMPKEERYEWLKKYGMGEFTGIDIAGEQQGLVSDWKTWDGRQEFTVFFGQGLAQTPLQTAMVFQAVGNLGVKVKPRIVDAIIDPDGTEHKVPVEGAQRVVSEKTARDCLTLMENVVTKGQAKLAQVNGYRVGGKTGTAEAPSEKGGYEGYTTSFIGVAPIENPRFMVSITLQRPKGEVGTIGGTGQFSQIMERVLHTYNIPHSTTEPHIIPIFADGKNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZJ4</accession>
    <name>A0A2Z5QZJ4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87878">
        <property type="protein sequence ID" value="BAV87878"/>
        <property type="gene ID" value="RA11412_1579"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1579"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="39" mass="4111" checksum="1FA6107C6AB49087" modified="2018-10-10" version="1">MEEWAHPHVCGEHAALGFVGGVVKGSSPRMRGTPAGQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZJ8</accession>
    <name>A0A2Z5QZJ8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein EngA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87644">
        <property type="protein sequence ID" value="BAV87644"/>
        <property type="gene ID" value="RA11412_1345"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1345"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="115" mass="12988" checksum="5698777416DFD825" modified="2018-10-10" version="1">MAENDAIRDDYEDKYLGGGEDDVTERLADIDDETAEARAQALLEGLEDYDLDEEDRALLGAWGFELDEEEEQLADPVVAIVGRPNVGKSTIINRIWVGVRPWWRISRGDPRPCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZN7</accession>
    <name>A0A2Z5QZN7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiol peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87826">
        <property type="protein sequence ID" value="BAV87826"/>
        <property type="gene ID" value="RA11412_1527"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1527"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AhpC-TSA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="91" mass="10123" checksum="630BA6AAD483C10B" modified="2018-10-10" version="1">MLGVSPDKLPALKKFTQNEELTFPLLSDADHAVAEAYGAWGEKKNYGKVYEGLIRSTFVIDEQGTIKIAQYNVRATGHVAKLRRDMGIDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZW4</accession>
    <name>A0A2Z5QZW4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitric-oxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87998">
        <property type="protein sequence ID" value="BAV87998"/>
        <property type="gene ID" value="RA11412_1699"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1699"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="68" mass="7361" checksum="73337658884565C9" modified="2018-10-10" version="1">MAKKPVTREEIAKVTRRTDAVGAYAGKGWVQAVAFVMLLGFTIMAILAMRTYALSMPLPDKSSATTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R043</accession>
    <name>A0A2Z5R043_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome-c oxidase</fullName>
            <ecNumber evidence="3">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome aa3 subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">coxB</name>
        <name evidence="19" type="ORF">I6I94_00885</name>
        <name evidence="18" type="ORF">RA11412_1803</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037234421.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88102">
        <property type="protein sequence ID" value="BAV88102"/>
        <property type="gene ID" value="RA11412_1803"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1803"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="17">
        <location>
            <begin position="138"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="BAV88102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QQT89226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="296" mass="33260" checksum="1016482F54E4782C" modified="2018-10-10" version="1">MSSQHRTGSHTPKSLSLFGLGTSMVLLVTGCSMDRASVGWLPVKPGQPATDNAENLMHLWVGTWAAALVVGLITWGLMLWCIIAYRRRKNETGYPRQLSYHLPLEVFYTFVPVVLIVSMFTFSDRVERQVTAPKSGSDRQVSVEVYGKQWAWDFNYTDANVHVTGVQAHLDGSEGKEAALPTLYLPANSNVDITLKSRDVIHSFWVPAFLEKRDTIPGMTNHIYITTKEPGDYKGKCAELCGEYHSEMLFNVKVVSREDYDKYIESLKQNPENQGVVGDEYNRNPNQNATPRPADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R057</accession>
    <name>A0A2Z5R057_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0246 protein YaaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87900">
        <property type="protein sequence ID" value="BAV87900"/>
        <property type="gene ID" value="RA11412_1601"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1601"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="198" mass="21476" checksum="49203EAC2F650577" modified="2018-10-10" version="1">MRRNTRLLHEPAHAAIQTYTGVLFEALDYGSFSPAERQLAQRTILISSALWGVVRPEDAIPAYRLSMGVKLGELGQLANFWRGALSSALAPVVAGELVLDCRSAAYAKSWVTPGAQTLAVRVERVSADGTRKVVSHMAKHYRGELARYLVRSGLAERDFTADADGAAALVEALGANWDVEWVAGTERKAGTLTVLIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0A0</accession>
    <name>A0A2Z5R0A0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">An allosteric effector of glucose-6-phosphate dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Glucose-6-phosphate dehydrogenase assembly protein OpcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_01115</name>
        <name evidence="1" type="ORF">RA11412_1744</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88043">
        <property type="protein sequence ID" value="BAV88043"/>
        <property type="gene ID" value="RA11412_1744"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1744"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004555">
        <property type="entry name" value="G6PDH_assembly_OpcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38658">
        <property type="entry name" value="PTHR38658"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10128">
        <property type="entry name" value="OpcA_G6PD_assem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="328" mass="36063" checksum="BC2BEA70C3752999" modified="2018-10-10" version="1">MISHLHHTNVSAISKELSQQLAANGSLSSGRVLTLVVLAEKGHSREALNAAIRASHEHPSRIIVHIAHSETDPDQLDAEIHVGGEAGASELIILRGWGSASKPTEALISGLLLPDAPIVVWWPHYVPDNPAEDSLGKIAQRRITDSARAYDPMAVLTHLSQVYQAGDTDLAWTRLTLWRTQLAALMEQMPYSPVKRVVVWGSEKSPSVVLLGAWLGWKLQAEVSLATIGAAERGLYRVAIEREDGQTVMFRPGKSIAILETPHAPQQQIALPVRTLAECISEELRRLDPDDTYGEVLKSAFPTIEMHPTRCDSEPLLDEREYPEVFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0C6</accession>
    <name>A0A2Z5R0C6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88073">
        <property type="protein sequence ID" value="BAV88073"/>
        <property type="gene ID" value="RA11412_1774"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1774"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="17"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="123" mass="13123" checksum="2544F00C6192DAC3" modified="2018-10-10" version="1">MKSAAPDLDDTRVRTILGSFLFSGDDVDKPAGVLSGGEKTRLSLATLVASSANVLLLDEPTNNLDPASREEILNALKAYTGAIVMVSHDEGAVEALNPERVLLLPDAVEDLWSKDYQDLISLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0G0</accession>
    <name>A0A2Z5R0G0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88222">
        <property type="protein sequence ID" value="BAV88222"/>
        <property type="gene ID" value="RA11412_1923"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1923"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="82" mass="9177" checksum="E00D199C9C7B050A" modified="2018-10-10" version="1">MAHLTQRTMRVLRKVSHNDGFNIGMNQGKVGGAGIADHLHQHILPRWSGDTNFLPIIAHTKTMSRTLDDMRQIIADGFAQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0U4</accession>
    <name>A0A2Z5R0U4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_1817</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88116">
        <property type="protein sequence ID" value="BAV88116"/>
        <property type="gene ID" value="RA11412_1817"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1817"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="267" mass="28156" checksum="401DAAC7B3FCD0DD" modified="2018-10-10" version="1">MTQNSQSHKQSNPHGQVHIQDAAPAHPHGAIDTSAANKKGLSSGSVSLFGSIIIGISVVAPAYSLSGALGPVGAVAGEHMPAIFLIGFIPMLLVAIGYRELNAAMPDAGTTFTWTTKAFGPWVGWIGGWALLAATILVLSNLAGIAVDFFYLALSQVFSNPDLATLSSNNLINIGTFLAFMAFGCYITYRGLDATQKIQTVFIIFQLVVLAIFAIVALYKAITGGVSLIYPQPLNGLTRLELNLSQLFHPVFLLCSLFTGAGTRCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R174</accession>
    <name>A0A2Z5R174_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4193 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_10680</name>
        <name evidence="4" type="ORF">NCTC10207_01463</name>
        <name evidence="2" type="ORF">RA11412_2198</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887546.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88497">
        <property type="protein sequence ID" value="BAV88497"/>
        <property type="gene ID" value="RA11412_2198"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2198"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025242">
        <property type="entry name" value="DUF4193"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13834">
        <property type="entry name" value="DUF4193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI23356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="99" mass="11126" checksum="660B4BD3D1558E62" modified="2018-10-10" version="1">MATDYDAPRKQDDEQNEESYEELNARRSEMQSGAVDEDENTAAESFELPGADLSNEELNVVVLPAQDDEFTCASCFLVRHRSQIAREEDGLVYCVECEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1E7</accession>
    <name>A0A2Z5R1E7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Valine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Valyl-tRNA synthetase</fullName>
            <shortName evidence="7">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 13" type="primary">valS</name>
        <name evidence="13" type="ORF">I6I94_11310</name>
        <name evidence="12" type="ORF">RA11412_2037</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
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        <location>
            <begin position="147"/>
            <end position="637"/>
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        <location>
            <begin position="685"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
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        <ligand>
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    <sequence length="910" mass="102304" checksum="4F13453DD5B3E459" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1F4</accession>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="QQT88871.1"/>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase"/>
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        <property type="entry name" value="SLH_dom"/>
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    <dbReference type="Pfam" id="PF00395">
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        <property type="match status" value="3"/>
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        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SLH"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
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        <source>
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            <dbReference type="EMBL" id="BAV88615.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="QQT88871.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="VEI23474.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="451" mass="49991" checksum="4E1E514F336A71D8" modified="2018-10-10" version="1">MNLKNKVRAGALAAITIPAIIGSTLTVPAQAAVASGTYRSYTAPNGLSSQYHVYANGIDWSQPVGVVFYVDGDYWEAKDSKVHSPNNGMLTAMGRIANARNMVFVPVISPDKNASGDGITWWENQDANGDYFRSFAQKFIADSGIDPSRVWTMGYSGGAEFITYELNADRQGSWRTGGGSIMVAGGSNTGMQTQAPQHIKSQPMYWWVGEKDTSGSTNPPTWSARTAVETGYNRYTQEGFNTRLRYIPNLSHHDYDLPHILAQSLDMGGYRMSAGYNDISEGAAFYNEISWNSDKRLMVGYADRTFRPHAKVNRASMAAYLYRLAGSPQVNLPAISPFRDVPVQHPAYKEIVWMYQQGITTGWADGTFRPHETVSREAMAAFFYRFNGSPAFNPGSQRFADVNTSNPFYKEIQWLAAKGITTGWPDRTFRPGAPTERNAMAAFLYRYANLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1G9</accession>
    <name>A0A2Z5R1G9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86739">
        <property type="protein sequence ID" value="BAV86739"/>
        <property type="gene ID" value="RA11412_0440"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0440"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="42" mass="4786" checksum="2BFE22486644001B" modified="2018-10-10" version="1">MKLSTKPVEFPLYWQHWNINSPVLETVSRRVAEAAKTGLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1J6</accession>
    <name>A0A2Z5R1J6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_10205</name>
        <name evidence="4" type="ORF">RA11412_2308</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88607">
        <property type="protein sequence ID" value="BAV88607"/>
        <property type="gene ID" value="RA11412_2308"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2308"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="3">
        <location>
            <begin position="6"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="410" mass="43367" checksum="C1D1957917D6CECF" modified="2018-10-10" version="1">MTANRVYLDHAATTDILPAAIDAMVQQMRTGGNPSSLHAIGREARAAVEYARERIAQAIGCDAAEVIFTSGGTEADNLAVKGMYWKRHSADSARRRILVSSIEHHAVEETCEWLETHQGAVIEWIPVDAQGLVHPDTVRELIAKNPADVALVTVMWANNEVGTIQPIAEIAQLAAEYGIPMHSDAVQAFGAVPVNFRESQVTTLAISGHKIGGPMGVGALIATRSADMTPVLHGGGQERSVRSGTIDAPAIAGFAEAAAHVTENLAEETQRIATLRNELVQSVRALIPQAHLSGIDPLTETSPGQKRLPGNAHFTFEGAEGDTILFLLDMQGIAASTGSACNAGVTRPSHVLLAMGMDEDTARGAQRFTLGHTSTGEDLARLLAALPDAYTQAAKAGLSSQLPDASRWYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1J7</accession>
    <name>A0A2Z5R1J7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88381">
        <property type="protein sequence ID" value="BAV88381"/>
        <property type="gene ID" value="RA11412_2082"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2082"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="97" mass="10848" checksum="3FD504470668BC8F" modified="2018-10-10" version="1">MQKRLGVTIDAETFLRSLTHRSYAFENPGVAHNERLEFLGDSVLSLAIAEEVFRRYPDMPEGELVKRHHVVVSTVALAKVARELRLGPHIRLGKGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1K5</accession>
    <name>A0A2Z5R1K5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4191 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transmembrane protein MT2276</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_10505</name>
        <name evidence="3" type="ORF">RA11412_2243</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887396.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88542">
        <property type="protein sequence ID" value="BAV88542"/>
        <property type="gene ID" value="RA11412_2243"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2243"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025445">
        <property type="entry name" value="DUF4191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13829">
        <property type="entry name" value="DUF4191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="236" mass="26320" checksum="C5DCCD376DE347E0" modified="2018-10-10" version="1">MADKEEKKQKPKRQGTFSQMKQVYQMTKKSDPNIGWILLFWSALTLLVFVAVGVLLNNWITLLILGVAAAAIVAMLILSRRAQNAAFTQIEGQPGRSGAAMNSVRRGWIVEEQPVAANRHQDLVFRGLGKPGIVLVTEGPSSRVQNLVRTEKKHLNRVVPGVPVHVIETGHDENQVELKDVVKTMNKLPKTLTQKEMQDVSGRLSTLNNIRNPMNGIPKGVDPNRVRPDRRAMRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1K7</accession>
    <name>A0A2Z5R1K7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="8" type="ORF">RA11412_2085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88384">
        <property type="protein sequence ID" value="BAV88384"/>
        <property type="gene ID" value="RA11412_2085"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2085"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="91"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="125"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="149" mass="16051" checksum="45F5FA502BF075FE" modified="2018-10-10" version="1">MLVICPGSFDPVHNGHLEIIARAASLFDEVVVGVAHNHSKKYLFSLQERVRLVTDSLAELGIEGVGVEIIPTGVLLAEYAAQRGASALVKGLRSGTDYGYEAPMASMNRRLSKVETVFLAGEDRYGGVSSTIIREVASLGGMCARLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1P4</accession>
    <name>A0A2Z5R1P4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-antigen export system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2283</name>
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    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88582">
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        <property type="gene ID" value="RA11412_2283"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2283"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="99" mass="11474" checksum="20DD005F44A7AD50" modified="2018-10-10" version="1">MVATWLSPVLYSWALVRDTLYPWVFNLFMMNPLTVAVELFHYAFWHPTLTDHDKLAPTSQVVPHLFSFWTPVAIGVSLLTVLIGDFLFRKFEGNFAQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Q0</accession>
    <name>A0A2Z5R1Q0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PHP domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Predicted metal-dependent phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09965</name>
        <name evidence="2" type="ORF">RA11412_2368</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
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    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88667">
        <property type="protein sequence ID" value="BAV88667"/>
        <property type="gene ID" value="RA11412_2368"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2368"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="288" mass="32045" checksum="A41962C3234C24D3" modified="2018-10-10" version="1">MTERYDLHIHSNISDGTQPLTELVPLIRDAGLAGFALTDHDTARGWPQAAELAVEYGLDFLPGGEFSCRYSYRDEQGHERTKSVHLLGYGYDPDYPQLRDEMKRLLDDRLSRARRMADRLAADYPLTWDDVLAQSSDGENTVFGRPHLADALVAVGAAENRADAFDNILHVNGPYHVHQQSMDPLEAIRLVRAAGGVPVVAHPMSEERGPALPLEYLGKMVEAGLAGVEVYHRENSEPNRARLLEFARERELLVTGSSDYHGAGKPNQLGEYTTSRETVEAIRAQISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1X2</accession>
    <name>A0A2Z5R1X2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86889">
        <property type="protein sequence ID" value="BAV86889"/>
        <property type="gene ID" value="RA11412_0590"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0590"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="PTHR18640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="106" mass="11819" checksum="4436C14C5956771B" modified="2018-10-10" version="1">MGGEFAKKPTTKWLDKFSVMMIVYSAFSASVVQGVWTRVDWWQIVLLVVITALMVAFMLWATDVIARKLGFNRADRITIQFCGSKKSLAAGLPMAIIISVPDRSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R229</accession>
    <name>A0A2Z5R229_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytosol aminopeptidase PepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_2232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88531">
        <property type="protein sequence ID" value="BAV88531"/>
        <property type="gene ID" value="RA11412_2232"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2232"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="6">
        <location>
            <begin position="367"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="462" mass="48092" checksum="2D3277B299C976B3" modified="2018-10-10" version="1">MCAHPSQLGAHLCPGPTQHEGVPYVPIPLRGPTNLESLESDVLVVGVYAGEESPRLAPCALSQETVEGINELLEALGATGAADQLLRLPGAEDAGADTIALIGLGQETTNAAERLAAFRYAAGSATRQLIGAEEIAIDFGTNAPAEIEAIAYGATLGSFSEKGMRGKSASSVKDEAETILIVSEVQPAEAEEALTRALVLGEATKQARHLVNQPPSHLYPESFAQQAQQLVSEYEDVSIEVYNYERLLAEGFGGIAGVGQGSPRKPVLAVVKYTPADAKASIGLVGKGITFDTGGNSLKPAASMMTMKCDMAGAASVLQATLAAAELNIPVQVTGYLCLAENMPGGESLRPEDVITIRDGRTVEVLNTDAEGRLVMADGIALASENEHDVIVDIATLTGAAMAALGLRTAALMGDEQVRERVLRAGEAAGEAYWPMPLESHLRASMNSPVADIKTWAAATAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R272</accession>
    <name>A0A2Z5R272_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6318 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_2272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88571">
        <property type="protein sequence ID" value="BAV88571"/>
        <property type="gene ID" value="RA11412_2272"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2272"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046281">
        <property type="entry name" value="DUF6318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19843">
        <property type="entry name" value="DUF6318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016258429" description="DUF6318 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6318" evidence="3">
        <location>
            <begin position="73"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="156" mass="16703" checksum="FA305FE8CC15B6EB" modified="2018-10-10" version="1">MLWLVGVGLGSLGLAACGGENKAAEQEPSSSSSASETPQDSGSATSSASGEASNTPDPNFSKGYSGGEKAPDGKYVMADYRGPAQNVRVPARPDESYKVNSLEGLKKSVFAWVEWSNYGIQTGDFDVARQFVSNEFTEEIERYDYYTKLYKEGAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R282</accession>
    <name>A0A2Z5R282_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">rplW</name>
        <name evidence="11" type="ORF">I6I94_09105</name>
        <name evidence="12" type="ORF">NCTC10207_01780</name>
        <name evidence="10" type="ORF">RA11412_2568</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887768.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88867">
        <property type="protein sequence ID" value="BAV88867"/>
        <property type="gene ID" value="RA11412_2568"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2568"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT88670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VEI23873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="101" mass="11204" checksum="E0DCF1548F3B3E05" modified="2018-10-10" version="1">MSVSTKSVYDVIIAPVVSEKSYSQIDEGKVTFEVAPNSNKLEIKQAIEKIFGVEVASVNTINRKGKRKRTRFGWGSRKDTKRAIVTLKDGHHIDIFGGPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R296</accession>
    <name>A0A2Z5R296_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bifunctional NAD(P)H-hydrate repair enzyme Nnr</fullName>
            <ecNumber evidence="9">4.2.1.136</ecNumber>
            <ecNumber evidence="8">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">RA11412_2524</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="9"/>
    <dbReference type="EC" id="5.1.99.6" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88823">
        <property type="protein sequence ID" value="BAV88823"/>
        <property type="gene ID" value="RA11412_2524"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2524"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="14">
        <location>
            <begin position="6"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00018591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV88823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="380" mass="40550" checksum="940A3F145089F9A8" modified="2018-10-10" version="1">MKLIYTGESIREAEKPYVQAPDYNGYLMQRAADALAEEAYDTLVSHGAPPHSGRVLLLVGPGNNGADTVYAGVRLHRLGYSIDAVLFDPTGRNLELIAREAGEGTRVLHTEQSLRNISDYSLIIDGILGTGARGPVRGEAGEYLGYLRSLQQLGTLPPVIACDIPSGVDSNDGTLNEPSLAAVRTVTFIGHKLPTGTGTAEHCGSIRLHTLGVPHALDNTEPALRVLETKDYRRELETPTVESHKYTRGVVGMLTGTPEYPGAALMSVHAAINTGVGMVRFGVNDEKLHALMLAHNPEAVCFSGPARQQQVHAWAGGSGTTSSEPTNRYLIEALEPAVLDAGAVDTVAEYLLTGKRLTAHKILTPTPVSCSGCWRRSLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2E3</accession>
    <name>A0A2Z5R2E3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Basic proline-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88772">
        <property type="protein sequence ID" value="BAV88772"/>
        <property type="gene ID" value="RA11412_2473"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2473"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="621" mass="67225" checksum="89FCB8C14954CD29" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2H4</accession>
    <name>A0A2Z5R2H4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear transport factor 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_09735</name>
        <name evidence="3" type="ORF">NCTC10207_01654</name>
        <name evidence="1" type="ORF">RA11412_2425</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887446.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88724">
        <property type="protein sequence ID" value="BAV88724"/>
        <property type="gene ID" value="RA11412_2425"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2425"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI23642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="121" mass="13249" checksum="0E39818B37DA9027" modified="2018-10-10" version="1">MSTEKTIRDYFAAIHRGGWQDFLAEDMTYGFNSALQDLGKEDYLNGAGNFLAMTIDVDVKHLVIDGDQAAVISDYFVKTPAGATAIFEVPEFLTIHNGKLTGISIFFDSAAFTALMKGEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2J8</accession>
    <name>A0A2Z5R2J8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_09590</name>
        <name evidence="3" type="ORF">RA11412_2455</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88754">
        <property type="protein sequence ID" value="BAV88754"/>
        <property type="gene ID" value="RA11412_2455"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2455"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="198"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="410" mass="44756" checksum="5BC82417FE748B50" modified="2018-10-10" version="1">MTPSPAAAQPRTHDEHKIDWISLGFSAPWLIFLGYIYDGVLEPNAPVWKHVYVIICLVIFSITDVAAYTVPWVLPVSSYFRRLLLWTALLFVPVCGVMLIAAIPPADVLIGFTIYFVALWTFTEDIPYSTRIRGAFTIAAVFWIIYMFSDGIPINFAEKSRLTLSLGAPMIGIMAFSYLIQMSKNADKTQAKLEMVSERERIAHDVHDVLGHSLTVITLKADLARKLLHADPDRADAELEAIAQLSRSSLAEVRSTVTRLRIPDFSGEIQASERALQTASVTAKLPDAERALSAVGVNSSLFSWVLREAVTNIVRHSQAGFCEVRVSNTGLEILDNGVGVPAEYAAGSGIKGMKSRVESAGGTLIVEDAPARWLRAHPAASGTADVRGTRLRVSMDGNTAEIEPSGETDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2K4</accession>
    <name>A0A2Z5R2K4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_08745</name>
        <name evidence="6" type="ORF">RA11412_2659</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88958">
        <property type="protein sequence ID" value="BAV88958"/>
        <property type="gene ID" value="RA11412_2659"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2659"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="153" mass="16112" checksum="1EE74707FB16697E" modified="2018-10-10" version="1">MSVNFAELEKGQEIGSRTVDISRASLVRYAGASGDLNPIHWNERFAQSVGLSGVIAHGMLTMGTAVQLVSDWAGDPGAIVDYQTRFTKPVPVPDAPGGDNPDTPTNALTITGKVGAVDEDARTARIDLTVTADDGEGTQQKVLMKTQAVVKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2L1</accession>
    <name>A0A2Z5R2L1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Isoprenylcysteine carboxylmethyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_09450</name>
        <name evidence="6" type="ORF">RA11412_2491</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_048751895.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88790">
        <property type="protein sequence ID" value="BAV88790"/>
        <property type="gene ID" value="RA11412_2491"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2491"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="156" mass="17606" checksum="2D833070D4CDE57C" modified="2018-10-10" version="1">MKRLAAALEYKVPPPLIGALCASLMWLICGMPPLTGRPPLLLVPALALVVLGLTVDAVGVLSFRRARTTVNPFAPERTVNIVSSGIYRLSRNPMYLGMACILTGWAVWLWQVQAVLGVVLFVAWITRFQIIPEERVLTQKFGTEYRQYRQRVRRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2L3</accession>
    <name>A0A2Z5R2L3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_08680</name>
        <name evidence="2" type="ORF">RA11412_2669</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88968">
        <property type="protein sequence ID" value="BAV88968"/>
        <property type="gene ID" value="RA11412_2669"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2669"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="120" mass="13536" checksum="B725AEE55BA0EA52" modified="2018-10-10" version="1">MTTNYYQTHDITNNNPNDLETLLFLDIYSSLDLDPADIPDAEKVEATTAVEAGDEQETDEDFSPFEGIGVTLTDPNIVARFNGVRRDLLREIRGGMCTVEQAQRYLEHLEITLLLEQDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2M0</accession>
    <name>A0A2Z5R2M0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aspartate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88943">
        <property type="protein sequence ID" value="BAV88943"/>
        <property type="gene ID" value="RA11412_2644"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2644"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="4839" checksum="486ED68962DEDA8D" modified="2018-10-10" version="1">MVGSVLMKRMLEESDFNDIPPVFFTTSNVGGEAPPSTARLNLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2P4</accession>
    <name>A0A2Z5R2P4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane component YkoC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89035">
        <property type="protein sequence ID" value="BAV89035"/>
        <property type="gene ID" value="RA11412_2736"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2736"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="70" mass="7705" checksum="B4B276A1B3837086" modified="2018-10-10" version="1">MFALMVQAIRRGSRLAVTMEARGFGAGARSWARVPAYSRRDAYLVVASVVIVALAYGVSWWLGALQFLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2S8</accession>
    <name>A0A2Z5R2S8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Preprotein translocase subunit SecE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88922">
        <property type="protein sequence ID" value="BAV88922"/>
        <property type="gene ID" value="RA11412_2623"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2623"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="4057" checksum="11DF7F9E845C0279" modified="2018-10-10" version="1">MLFFVVFMLLLISGLDWVFGQGAFWVFGNGTIQTGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2T4</accession>
    <name>A0A2Z5R2T4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89077">
        <property type="protein sequence ID" value="BAV89077"/>
        <property type="gene ID" value="RA11412_2778"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2778"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4702" checksum="B7EAF086E2BD2747" modified="2018-10-10" version="1">MRRKLNVLMRPGMSAMHEENSRAFSKISCNFPAFTEVTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2V1</accession>
    <name>A0A2Z5R2V1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89095">
        <property type="protein sequence ID" value="BAV89095"/>
        <property type="gene ID" value="RA11412_2796"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2796"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="39" mass="4361" checksum="558A545EA5F3372E" modified="2018-10-10" version="1">MWGGTAMGKRLRWVSGQEAGTPKEQVSFMGYWRVGKTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Y3</accession>
    <name>A0A2Z5R2Y3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7 8">Pantothenate kinase</fullName>
            <ecNumber evidence="4 7 8">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">coaA</name>
        <name evidence="11" type="ORF">I6I94_09285</name>
        <name evidence="10" type="ORF">RA11412_2527</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7 8">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the prokaryotic pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="4 7 8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88826">
        <property type="protein sequence ID" value="BAV88826"/>
        <property type="gene ID" value="RA11412_2527"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2527"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02025">
        <property type="entry name" value="PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00215">
        <property type="entry name" value="Pantothen_kinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004566">
        <property type="entry name" value="PanK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285:SF139">
        <property type="entry name" value="PTHR10285:SF139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000545">
        <property type="entry name" value="Pantothenate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00554">
        <property type="entry name" value="panK_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7 8" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="9">
        <location>
            <begin position="91"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="96"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT88704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="318" mass="35649" checksum="43B935B8CE8B1C32" modified="2018-10-10" version="1">MSSASTSAAWSRFTELERTRWSRLSAEISVPLTGAEIEDLRGLGETINLEEVQQVYLPVSRLLNLYVNAASSLNHMTNDFLGVSQRRVPFIIGVAGSVAVGKSTTARVLQALLRRWPSTPKVQLVTTDGFLYPNAELQRRGIMHRKGFPESFDRRALLEFVSAVKSGVPQVSAPKYSHLYYDILPDERIEVNTPDVLILEGLNVLAPAGTEGPETSDLTLSDFFDFSIYVDALTEDIQRWYVERFLSLRSSAFSNPNSYFRRYAELDDTQAAEVATGIWKSINEPNLVHNVLPTRARAHLILQKGANHSVQRVLLRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R380</accession>
    <name>A0A2Z5R380_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89060">
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        <property type="gene ID" value="RA11412_2761"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2761"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="3963" checksum="727D9D553A24AA78" modified="2018-10-10" version="1">MGRAVSTALFLPFGRVVFWGAAGLSVGAADTGRLPAGGNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3C3</accession>
    <name>A0A2Z5R3C3_9MICC</name>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">I6I94_08305</name>
        <name evidence="1" type="ORF">RA11412_2762</name>
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    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
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            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89061">
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        <property type="gene ID" value="RA11412_2762"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="325" mass="35330" checksum="882AE65154B220DA" modified="2018-10-10" version="1">MRIHSPVEKLLTAWVIGVIVSLVAAAGALFATNKLVYGPEGKVREYFHALQTGNGSYALGLLGARIPDGDPAMLDGDTLRRAASTLKDVQIDVIEKDPNGNEATVRASYTIDGKSEHTDFRLHQAGTHWGVFDRWDIESGELPTLTVKIAGVEAATVNNRKVAVDQGEASFPVFYPGVYTVAYDSAVYTASKSVQQVLTADASSQADIALEPSEKALESVQTQVRSYVDKCAAQNTLYPSGCPFEYSFGGRVDGAVKWSVIEYPQPKVTAESDKMWRLSPAEGKVKISFEQLDLYTGTHKEITKEIPFTLKGMAEVDAKSVRVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3Q1</accession>
    <name>A0A2Z5R3Q1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3039 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Protein of uncharacterized function (DUF3039)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_02105</name>
        <name evidence="4" type="ORF">NCTC10207_00870</name>
        <name evidence="2" type="ORF">RA11412_1490</name>
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    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
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            <taxon>Actinobacteria</taxon>
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    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037235529.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87789">
        <property type="protein sequence ID" value="BAV87789"/>
        <property type="gene ID" value="RA11412_1490"/>
    </dbReference>
    <dbReference type="GeneID" id="32323200"/>
    <dbReference type="KEGG" id="raj:RA11412_1490"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021400">
        <property type="entry name" value="DUF3039"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11238">
        <property type="entry name" value="DUF3039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI22784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="100" mass="10892" checksum="25B28C8EF0D2707E" modified="2018-10-10" version="1">MSSIEGIEDPFGTKPAGGTSLLEREETQLSEPGDHERFSHYVRKEKIMESALTGEPVRALCGKVWTPGRDPQKFPVCPTCKEIYEGLKPGKDGGDNGGDN</sequence>
</entry>
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    <accession>A0A2Z5R3S2</accession>
    <name>A0A2Z5R3S2_9MICC</name>
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        <submittedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">RA11412_1620</name>
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    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87919">
        <property type="protein sequence ID" value="BAV87919"/>
        <property type="gene ID" value="RA11412_1620"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1620"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
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        <property type="entry name" value="Acyl_transferase"/>
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        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
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        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="181" mass="18775" checksum="6C2BC8473647B048" modified="2018-10-10" version="1">MRALVCPGQGSQKKSFLSPWLEIDGVREHLQRLSDAAGIDLIHYGTEAEEETIKDTAIAQPLIVAAGIVTGRKVLQKLGESKLILAGHSVGEITAAALAGVLTEEDAMRFVRVRATGMAQAAAASPTGMAAVLGGVEQDVRQAIDEAALVAANSNGAGQIVAAGPLKLLRRSPPTRPPEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3T8</accession>
    <name>A0A2Z5R3T8_9MICC</name>
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        <submittedName>
            <fullName evidence="3">Type I restriction-modification system</fullName>
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    </protein>
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        <name evidence="3" type="ORF">RA11412_1690</name>
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    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87989.1"/>
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    </dbReference>
    <dbReference type="REBASE" id="162567">
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    <dbReference type="EnsemblBacteria" id="BAV87989">
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    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1690"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0680">Restriction system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="196" mass="22296" checksum="3CC80CF9E7380DBE" modified="2018-10-10" version="1">MTTIGDIALSTQYGTSTKSGDTGKYPVLRMGNITDNGHLDLTDLKYQDIKESEIPKYTVAINDMLFNRTNSKEKVGKSAVIKSNIPLAYAGYLIRVRYKNPHYAEFVATYLNSTYGKSLRQKMAKSAVNQANINATELKNIPIPSIPKEILSNFSYKINKIEKFRNYIYKTLKDNEVLYNSLQYYLYNFIGGNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3W5</accession>
    <name>A0A2Z5R3W5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Energy-coupling factor transporter transmembrane protein EcfT</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Transmembrane component BioN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_01020</name>
        <name evidence="6" type="ORF">RA11412_1770</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88069">
        <property type="protein sequence ID" value="BAV88069"/>
        <property type="gene ID" value="RA11412_1770"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1770"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="220" mass="23970" checksum="844847689EF6733B" modified="2018-10-10" version="1">MSKRTRPKRDGSFQAKFSPGAALIGSYRPLATPVHRVPLWLKACLFAAFMFLLALTGWQVAFGVCAVCLILAYSAGIKTMELLRMLYAMRWLLILLAFYYALWGGWDLGADVLATLLAATLASRIILTSTPLPVLIDGVVTFCAPLRFVGVRSERLGLAIGLMIRSIPAIMDRWGTLLKAAAARGLPAKSTWRLITPLVVQTVDYAQKTGDALAARGLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3Y4</accession>
    <name>A0A2Z5R3Y4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-aminobutyraldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_1820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88119">
        <property type="protein sequence ID" value="BAV88119"/>
        <property type="gene ID" value="RA11412_1820"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1820"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="235" mass="25696" checksum="C4CBF0C9A148D709" modified="2018-10-10" version="1">MKRSHLELGGKAPAVVFADADLPRTARMLADFGYFNAGQDCTAVTRVLVQDSVYEQFRDLLVAAARDTVTGNEDDSKNFYGPLNNVNHFNTVMGKLKGLPGHVTVETGGKQCGTRGFFIEPTVLSGVHQDDAIVQEETFGPVLTLQPFTTEQEAINLANDVDYALASSVWTSNHGTAMRVSRDLDFGAVWINTHVLLTAEMPHGGFKFSGYGKDLSLYSVEEYTRVKHVMSDLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4G0</accession>
    <name>A0A2Z5R4G0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Immunity 22 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_10635</name>
        <name evidence="1" type="ORF">RA11412_2210</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88509">
        <property type="protein sequence ID" value="BAV88509"/>
        <property type="gene ID" value="RA11412_2210"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2210"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025560">
        <property type="entry name" value="Imm22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14112">
        <property type="entry name" value="DUF4284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="119" mass="13681" checksum="B415A00EE0EDEC4A" modified="2018-10-10" version="1">MNNSVAIWVGRFDSDQELQDYLDIDYTAEQDNSEYMASEFAEAFKIFHHDEDFREAYRTEVEPVSWAGLAEPLSYAEGFAHTVPNITDRNNSIIALYNYTYPGTVHGTENVVFVGNYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4G3</accession>
    <name>A0A2Z5R4G3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88529">
        <property type="protein sequence ID" value="BAV88529"/>
        <property type="gene ID" value="RA11412_2230"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2230"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025447">
        <property type="entry name" value="DUF4192"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13830">
        <property type="entry name" value="DUF4192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="244" mass="27124" checksum="D69047431321AE8A" modified="2018-10-10" version="1">MAAIMLHQLGYWPQESFVVVALAAHNIGPCVRIDLPGPEDNTAAYLHRIFSLLPATIDGAQPIDRFIAFYCTADRDNLRARQTASGTRTLPSTSERERDAAIAHRVERWLPLLTNSTVTGGLECFDCIVLGDTTIWELSHEQNRLIFAGFVEDILMSPYHLAQTVRGESIAATASEARTTNPWDTAATADTGAREDWEAAAELWYRTYTQEYQLRHAEGEDPHLLQAHSYCQQKGLSSATGKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4I5</accession>
    <name>A0A2Z5R4I5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">prfB</name>
        <name evidence="8" type="ORF">I6I94_10370</name>
        <name evidence="7" type="ORF">RA11412_2270</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88569">
        <property type="protein sequence ID" value="BAV88569"/>
        <property type="gene ID" value="RA11412_2270"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2270"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="273"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="375" mass="41348" checksum="3FFC5BAB794981F5" modified="2018-10-10" version="1">MASFDFSAEIRELRAVYASIAAVSDLEGIERAIAELSERAADPQLWDDPQVAQQVTSALSHKQAELNRLTSLGSRIDDVEVMVELAEAEDPQSAQELLSEARTECVSIRRKLEELEVLVLLSGEYDQREAVVTIRSGAGGVDAADFAEMLLRMYLRWAEKNGYPTKLLDTSYAEEAGLKSATFEVNAPFAFGRLSVEAGTHRLVRISPFDNQGRRQTSFAAVEVVPLIEQTDAIEIPETEIKVDVFRSSGPGGQSVNTTDSAVRMTHLPTGIVVSMQNEKSQLQNRAAALRVLQSRLLLLRKEEEDAKKKELAGDIKASWGDQMRSYVLHPYQMVKDLRTGYEEGNTANVLDGGLNAFIDAGIRWRASSRSAGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4P6</accession>
    <name>A0A2Z5R4P6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88719">
        <property type="protein sequence ID" value="BAV88719"/>
        <property type="gene ID" value="RA11412_2420"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2420"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016449056" evidence="2">
        <location>
            <begin position="32"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="408" mass="43633" checksum="398C4B6D048D5247" modified="2018-10-10" version="1">MRSFPTRSVLAGACTLALIGGTAATLSPVNAAPPATSNTVQGGSSSLPGNNNNNDNANNNPDNVQQTKITSVEGGPLNPITGENTLTITGEGIDPNQSFESLQAEVYELDADGDRTGKNLAQDDAKLTVTEDGHFSGTAKVKGNFDPQKRYAVFAVIYSGHGYHTVEARQDLPVQQVDEKNVHPSVTVTPDFAWNNTFYRHLNTNTLTVRGTRQEGATRLIIRVEALDENGKVTETLVTKDASADLNGGNFTTKVQVPGSKIESGKRYQVVVETGANDWSRAEVEDFRGDTESEAVGIVDGAPLSRSAAENHLKVAGGGFDPAVAAQNGSKVRLIFAEYDIENDIIRDDEIVNTTVTPKPNGDFESELTIPGNKLQAGKKYVVRAYLEDADGRVSSDITLKTLVPTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4W0</accession>
    <name>A0A2Z5R4W0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sucrose operon repressor ScrR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88909">
        <property type="protein sequence ID" value="BAV88909"/>
        <property type="gene ID" value="RA11412_2610"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2610"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="391" mass="43796" checksum="EBA711A3275654D0" modified="2018-10-10" version="1">MFSRRIKCTITFTVKIAYVYCKGDLPVSKPKLGDVAARAGVSPTTVSRVLNNRGYLSQRTREKVYDAMRELGYRPNAIARSLKGQRSRIVGLVFPTVANPFYAEMVYRIESFLADAGYRVILCNSDDHPDLEEQYFEMLLSNQVDGIITGAHSQVVANLPHVQAPLVTVDRPGTQKYPNIRADNYAGARMAVEHLVATGAGNILHITSTVSEQNLRLAGYRDAVTAAGMTPQVLELGFRTPLPRKRELIERYLKESTTGERVDAVFASNDTYAAMTLNWARTRNLCVPRIFRWWGLTAPRQYAHLSRILQLWCSRLSRSPRVQCSGCFRRSNRADRATPTIHHRLIKAIRSNRVPRLMFSQCTCTKAVPSGPLPPPLSGTPDLATSSLCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVD7</accession>
    <name>A0A2Z5QVD7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07930</name>
        <name evidence="2" type="ORF">RA11412_0058</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86357">
        <property type="protein sequence ID" value="BAV86357"/>
        <property type="gene ID" value="RA11412_0058"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0058"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="118" mass="12989" checksum="A12F44EE54767AAA" modified="2018-10-10" version="1">MNIPEWLLALPSISGFLTLLAAIIGAVAVLRASRERAREAVSAEFQDQMQWAAKYVGDSSKPYEQAFALMLIDRYAHKPPKLLGAEDLEIAQQMQDIVARTLDITGFPPDSENSNGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVE1</accession>
    <name>A0A2Z5QVE1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86350">
        <property type="protein sequence ID" value="BAV86350"/>
        <property type="gene ID" value="RA11412_0051"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0051"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
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                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
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                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
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            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
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    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887079.1">
        <property type="nucleotide sequence ID" value="NZ_JPVS01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86512">
        <property type="protein sequence ID" value="BAV86512"/>
        <property type="gene ID" value="RA11412_0213"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0213"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="28"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI24596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="288" mass="31182" checksum="F5F17585EB4D1007" modified="2018-10-10" version="1">MYDYHRNERAMALRPSLSRSWLLVRANSDEATMEAAFESEADSVILDLEDGCPADEKDEARKRVVEILNTEARAWVRINAITTEHWWNDVKALSGVKGLRGVMLATTEHSTDIDRTAAALPTGTPIIALIESALGVHNAVKIASAIGTFRLAFGVGDYRRDTGASDDPMALAYVRSQLVIASTLGGLPGPIDGPTLGKRGAELVTACQHGTVHGMTGKLTLDVGQADTINHALSPSEDEIQWAHSLLDVPLDGPKDGSYMPRFLRAKKVAELARVYGLWGKLEGEKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW71</accession>
    <name>A0A2Z5QW71_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurium resistance protein TerD</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TerD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06750</name>
        <name evidence="2" type="ORF">RA11412_0333</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023133111.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86632">
        <property type="protein sequence ID" value="BAV86632"/>
        <property type="gene ID" value="RA11412_0333"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0333"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="3"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="192" mass="20990" checksum="C2E6E9ED0BED31FE" modified="2018-10-10" version="1">MAAIKLTKGNPINLTKEAPGLKNLTIGLGWDLSIAGEAYDLDASVMLTDENDKIIFDDASLIFFNNPTSADGAIVHTGDNRTGDAEGDDETIIVNLEKVDPQIQRVHILASIYEGEKTGKNFGVVRNAYVRLINDDTNEEIARYDLSEDCSAAPAVLFAVVYRHNGEWRFKAVEDPFTGGLPHLLTSYGFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW86</accession>
    <name>A0A2Z5QW86_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Choice-of-anchor M domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_06595</name>
        <name evidence="4" type="ORF">RA11412_0376</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86675">
        <property type="protein sequence ID" value="BAV86675"/>
        <property type="gene ID" value="RA11412_0376"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0376"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022435">
        <property type="entry name" value="Surface-anchored_actinobac"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03769">
        <property type="entry name" value="P_ac_wall_RPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340135" evidence="3">
        <location>
            <begin position="34"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="344" mass="36348" checksum="30F185BCDA1458F5" modified="2018-10-10" version="1">MKNSIFSINTGQKVISAALSAALLVSAGGVAHADPSPAAASSRPSGDNLSKEQKALQQTLSPEQPVGTGRTEISSGHVDMGPRFTDGKFQLMIHDDHAATPIWRSVDDVLYRGSDAALRQVPDDDRYSFVGARPGEQVYVIPQTETKGVVWPGWTTQDPGLVQKTPRGVTLTLEQVQGPGQFTLYLENGNFSKPQVLWDSSKHEPQDIWVEKNTHTHANWVFTKPGAYLLKVTARAELADGSVVSDTRYMKFAIGDSVTADEVYALAQQATDQAPAGESEGAHSAAASDSPGASSGGFPVLPVALGAGAVAVLAAAGLVMMRRNKAAQAQAERITASGKGTRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW88</accession>
    <name>A0A2Z5QW88_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86668">
        <property type="protein sequence ID" value="BAV86668"/>
        <property type="gene ID" value="RA11412_0369"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0369"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="76" mass="8610" checksum="FE61923128C31D0B" modified="2018-10-10" version="1">MNNLMMPRRTTKYLSITAGATSYLSINPNGTITHRTWTGRRITTPINAYTYTPTETTAEGDFHPDQLKLYNSKGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWC0</accession>
    <name>A0A2Z5QWC0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative traG-family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Type IV secretory system conjugative DNA transfer family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_06705</name>
        <name evidence="4" type="ORF">RA11412_0344</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VirD4/TraG family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86643">
        <property type="protein sequence ID" value="BAV86643"/>
        <property type="gene ID" value="RA11412_0344"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0344"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003688">
        <property type="entry name" value="TraG/VirD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02534">
        <property type="entry name" value="T4SS-DNA_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="618" mass="67266" checksum="AB6501F8583B468B" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWG3</accession>
    <name>A0A2Z5QWG3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein kinase PknA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_0432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86731">
        <property type="protein sequence ID" value="BAV86731"/>
        <property type="gene ID" value="RA11412_0432"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0432"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="4">
        <location>
            <begin position="305"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV86731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="423" mass="42468" checksum="67E435BB5C4DD9E9" modified="2018-10-10" version="1">MYSLGIIGYEALAGHRPFTGESQIAIALAQVNDTPPPLPDSVSPTARALIMCLLAKDPSERPASATALAAAIDAIRRNDVRAALKAVPALKQFMPKSATAATATQTQTQVQQSAATGATGAITAAAAPRFGSGGRFSPNPTTAPIPPVAGTGAQPVQHVDDEDEPEQKRSGIVKWVVIGVVILLVVALALWAATALQGSPKNDPSGSPSVSASASPSEQEPSSSPATNNPDTQKQNNVTVNPAEFVGRSLLEVTNELSQMGLQVKPEGVDSNEAKDTVLSVSPSGSVEKGTSIIVKYSNGPKTATIPTGLIGQDKDTASAAIVKLGINVNQISEHSDTAAPGTVLRITPLPGTQVPLHSSVDVYIADASSGQGSGGAAPSANTSTSASASASASTPPRQPTSAPASTSATSSASAAAAATPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWL0</accession>
    <name>A0A2Z5QWL0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PTS system mannose-specific EIIAB component</fullName>
            <ecNumber evidence="4">2.7.1.191</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">EIIAB-Man</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">EIII-Man</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">manX</name>
        <name evidence="22" type="ORF">I6I94_05960</name>
        <name evidence="21" type="ORF">RA11412_0516</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 23">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="22 24" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 24">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannose 6-phosphate(in) + L-histidyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:49232"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.1.191"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.191" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86815">
        <property type="protein sequence ID" value="BAV86815"/>
        <property type="gene ID" value="RA11412_0516"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0516"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00006">
        <property type="entry name" value="PTS_IIA_man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00001">
        <property type="entry name" value="PTS_IIB_man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.35.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013789">
        <property type="entry name" value="PTS_EIIA_man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033887">
        <property type="entry name" value="PTS_IIA_man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004720">
        <property type="entry name" value="PTS_IIB_sorbose-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036667">
        <property type="entry name" value="PTS_IIB_sorbose-sp_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03830">
        <property type="entry name" value="PTSIIB_sorb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52728">
        <property type="entry name" value="SSF52728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00824">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51101">
        <property type="entry name" value="PTS_EIIB_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="19">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-4" evidence="20">
        <location>
            <begin position="164"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="BAV86815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="QQT88107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="329" mass="35183" checksum="6022FB5B9E8A7815" modified="2018-10-10" version="1">MVTIIVAAHGESAPALLKTASMILGNLDNVYPVTFLPGQGPEDLIEEYTRIVAEAGSEETLILVDLFGGSPYNAGARFAAEHENIDVVAGVNVPMLIEVISGAGRKNATLKGLVAKAHKAGVKGIRSFQEANQPVQDEKPAAETKPAEAPVAPEIPAEQQVEGGHMDAIFTRIDSRLIHGQVAGTWVPYVAPQTFIAASDAAAHDKLRKSLLLQVAPAGVKTNVLDIAKAGRVYNNPKYTGMKTMFVLESPVDVVRLLDEGVEIPEVNVGGVTYKTGMTQLSEAVYASEEDLEAYRELLKRGVKLYVQQLPNHSPVDMAKILKEKGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWM8</accession>
    <name>A0A2Z5QWM8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_0497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86796">
        <property type="protein sequence ID" value="BAV86796"/>
        <property type="gene ID" value="RA11412_0497"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0497"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV86796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="108" mass="11517" checksum="97C991DF6F6FBB07" modified="2018-10-10" version="1">MIGNWRYLLVYLTAILGGSAAVWVLEPHAVVVGASGGIFGLMGAYLTIMVALKERDNVRSVMVLIGVNVIYGFIMPGISWQAHLGGFIAGAIATLLCIAPQLMRSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWN1</accession>
    <name>A0A2Z5QWN1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_05975</name>
        <name evidence="1" type="ORF">RA11412_0513</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86812">
        <property type="protein sequence ID" value="BAV86812"/>
        <property type="gene ID" value="RA11412_0513"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0513"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="255" mass="28747" checksum="F571250A217FB56C" modified="2018-10-10" version="1">MKKLMAFDLDGTLLFDREIEPANVQAIHRWQQAGNIAVCATGKSIFATKLALDTADVTFDYNVLYTGAVVTDAEYNILHAQTLSFAVVRACYERFTKEPGVALFATTLTHDYRLADNVGSSTNILPEFLPLAESEIDTQDYVGVPLWIPEDDARERAYRWILEEFGDAVDCHKNQDFLDIVPQRCTKATGLAWLVEYLKPVEYETYTIGDSWNDVPMHEWADHAASFSYSPDDVKARTEVSVDRAWEFIDVSLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWS6</accession>
    <name>A0A2Z5QWS6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anchored repeat ABC transporter, substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Zinc ABC transporter periplasmic-binding protein ZnuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_06600</name>
        <name evidence="5" type="ORF">RA11412_0375</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006889050.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86674">
        <property type="protein sequence ID" value="BAV86674"/>
        <property type="gene ID" value="RA11412_0375"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0375"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022434">
        <property type="entry name" value="ABC_LPXTG_lipo_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03772">
        <property type="entry name" value="anch_rpt_subst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340094" evidence="4">
        <location>
            <begin position="29"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV86674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="544" mass="58239" checksum="4258E0657CF1F542" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWT9</accession>
    <name>A0A2Z5QWT9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86851">
        <property type="protein sequence ID" value="BAV86851"/>
        <property type="gene ID" value="RA11412_0552"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0552"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="173" mass="18679" checksum="D47C8C43E81B6112" modified="2018-10-10" version="1">MAKWLYSIGDFAARKAWVIIAIWALLIGGVSASYAAFHGQLKNTFTMPGTETQRLSDELSSRFPDANRGSGQVVVTTGDGSRITDEQKQAFTASLKRLKGEVSSVDAVSDPFETEKQLTDGQKQLTEGKQKVGGAPSSSKTVKNRLPTVSGRSMRVKSRLKAGSSRLITVISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWX8</accession>
    <name>A0A2Z5QWX8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86843">
        <property type="protein sequence ID" value="BAV86843"/>
        <property type="gene ID" value="RA11412_0544"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0544"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="4166" checksum="1386FB417333C27C" modified="2018-10-10" version="1">MRDTVLLLCAAYASTMLCEKNGKNRHCTPKLPLPFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWZ1</accession>
    <name>A0A2Z5QWZ1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Protein YdjA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05440</name>
        <name evidence="2" type="ORF">RA11412_0658</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86957">
        <property type="protein sequence ID" value="BAV86957"/>
        <property type="gene ID" value="RA11412_0658"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0658"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="242" mass="27708" checksum="092FAFED9CA5B211" modified="2018-10-10" version="1">MSLLDLLNRRRSVRHYDENQPIDADVVKECLRAAQLAPTSSNMQLYELYHVTDPAVLNKLAAACMHQQAAKTAQQMVVFVTRQDLHRRRAKAALEFERGNVERNSPPEKQKDRIKNWEMYYTKAMPFVYARCFGLLGASRAAMANCAGLFVPMMREVSEHDYRVVVHKSCGLVAQTFMLAMTEAGYDTCPMEGFDSHRVKKLLGLPRNVEINMVVACGIRKPGHGIWGERFRLPFNEVYRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX51</accession>
    <name>A0A2Z5QX51_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mobile element protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="16">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I6I94_05240</name>
        <name evidence="15" type="ORF">RA11412_0703</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87002">
        <property type="protein sequence ID" value="BAV87002"/>
        <property type="gene ID" value="RA11412_0703"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0703"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="14">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="12">
        <location>
            <begin position="280"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="13">
        <location>
            <begin position="428"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="511"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV87002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QQT89993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="545" mass="61657" checksum="BD0DBBED13AFA014" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX69</accession>
    <name>A0A2Z5QX69_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05045</name>
        <name evidence="2" type="ORF">RA11412_0746</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87045">
        <property type="protein sequence ID" value="BAV87045"/>
        <property type="gene ID" value="RA11412_0746"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0746"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="227" mass="25304" checksum="72DB9AF6E5521C12" modified="2018-10-10" version="1">MEQHPPQPSEYQQYAPQNVYGYQQVVTEKPERNKTVNIGLMLLYIYIGITVLSTALEVVISFATNRYEHLAELQNYDSYSSGVTIDTGTYTAMVITITIIMLVVKVSLMVLFTLMYRAGRTWARILSAVLAILAALQSLWGLISIPFLAAVDPGIVPDYMHSAVVAARDTAIFTFAFNAVGGANAVAIAIFLLKKEASEYTAQYAAWRTYRRSATERAIYGSQQMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXD1</accession>
    <name>A0A2Z5QXD1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87031">
        <property type="protein sequence ID" value="BAV87031"/>
        <property type="gene ID" value="RA11412_0732"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0732"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="419" mass="46083" checksum="717E0D4A803CA0C4" modified="2018-10-10" version="1">MYTSARKHTRSYLSEGARRVRTGFFQSLQITISGIGAYFFSFYVLGHQEPIFAATAAIVSLGYVSGSTHSRRILEVSLGVTCGILVGELLLMALGRGPWQAAVALFLSVLLARFIDNGIIFTIQMSAQSCLVILLPPTSDLPFTRSLDGVVGGVAAFLMMFLMPKDPRNSPRERAEALMGAFSDVFFLSASAIREYNYEKAYQSLRDARQLQPLYDACRNDLVTARGMAQLSWVGKKSRAELDRLAQTLNAVDLAIRNDRVFNRRMASTIAHVQLRPAALESLAAALESLALATQSVGLGMYSGTEQERAHYMQVARERLVDLAGTLEPRQMGVASFEGESLVLMLRLMTVDMLEATGLGHEQASAALVKLGEAVTEHAPRTSEIPIVQANSNQDEQEDLRSRTINIILHDQELEKHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXI2</accession>
    <name>A0A2Z5QXI2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Predicted L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_0866</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87165">
        <property type="protein sequence ID" value="BAV87165"/>
        <property type="gene ID" value="RA11412_0866"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0866"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024569">
        <property type="entry name" value="4Fe-4S-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11870">
        <property type="entry name" value="DUF3390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3390" evidence="4">
        <location>
            <begin position="112"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="254" mass="27135" checksum="CEDCA7F177B7A72D" modified="2018-10-10" version="1">MDGCNPGDGPQNLHVILIDNGRTAVLADELGRQALRCIRCSACMNVCPVYERAGGHAYGSTYPGPIGAILSPQLSGIEAAHNNSLPYASSLCGACYEVCPVKINFPEVLVHLRGKDVDAKHAAGEFAGRKKHAPTQMDAMMYGAKKLFSSGKMMAVAERGLPMSRLITGKKHKISKLPGIVGGWTEYRDIPEPPKESFRNWWRKEKSGAPARDSAQRVDIAALIEANKGKAAEAAANAKAAMDAQAAHDPKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXJ4</accession>
    <name>A0A2Z5QXJ4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class IIb bacteriocin, lactobin A/cerein 7B family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_04850</name>
        <name evidence="1" type="ORF">RA11412_0792</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87091">
        <property type="protein sequence ID" value="BAV87091"/>
        <property type="gene ID" value="RA11412_0792"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0792"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023991">
        <property type="entry name" value="Bacteriocin_IIb_lactobn/cerein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010133">
        <property type="entry name" value="Bacteriocin_signal_seq"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03949">
        <property type="entry name" value="bact_IIb_cerein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01847">
        <property type="entry name" value="bacteriocin_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="65" mass="6874" checksum="244FF5DE4C78070A" modified="2018-10-10" version="1">MAKDTMFMEELTDQELEQVNGGCYSSCGYYGGSYGGSYGGSYCGSGSSYYGGGYYYAAVGYGYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXJ8</accession>
    <name>A0A2Z5QXJ8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87040">
        <property type="protein sequence ID" value="BAV87040"/>
        <property type="gene ID" value="RA11412_0741"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0741"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="152" mass="16774" checksum="45E2B54EB8869E8B" modified="2018-10-10" version="1">MSENPHSHNDEVQDSSASAPVHSTEYSHDEQTDATVPLTPEYAAELREPNVPADADAAEVTVPWGTHPSADTAERKGTRSRAVNPLSWMQPARCLRCWMIRSLVNVTSWNLPVFFPPIRALRTLRLRQPGCFLRTVPSPDGRHEAAAAARAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXQ2</accession>
    <name>A0A2Z5QXQ2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panC</name>
        <name evidence="7" type="ORF">I6I94_05180</name>
        <name evidence="6" type="ORF">RA11412_0715</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87014">
        <property type="protein sequence ID" value="BAV87014"/>
        <property type="gene ID" value="RA11412_0715"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0715"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="183"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="220"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="315" mass="34679" checksum="5F13610C4CBEBDE5" modified="2018-10-10" version="1">MTEITKPLVVKTIAEFRAAIAEALVAAQEKLDAQARAAAAENGTVVEYTDASLGYVPTMGALHHGHANLMRRAREQNEVVAISVFVNPLQFGPDEDYEKYPRTLEADVELAARVGVDIVFAPEVEEMYPDGEPLVRISSGELGSRFEGATRPGHFDGVLTVVNKFFNIIGSATGGHRVNAYFGQKDAQQFLLVQRMVRDFNHDVTLRAVAIVREDNGLALSSRNEFLSDDEREAALVISRTLALLREHSLNRGFEGIDLDGARERINATPGVRLDYLELVDPNNFNAPTSESERVLALVAAYVGQTRLIDNMDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXS9</accession>
    <name>A0A2Z5QXS9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_04705</name>
        <name evidence="8" type="ORF">RA11412_0821</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87120">
        <property type="protein sequence ID" value="BAV87120"/>
        <property type="gene ID" value="RA11412_0821"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0821"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="24"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="588" mass="62285" checksum="FC97F4F1092648A5" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYA1</accession>
    <name>A0A2Z5QYA1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87447">
        <property type="protein sequence ID" value="BAV87447"/>
        <property type="gene ID" value="RA11412_1148"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1148"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="68" mass="7198" checksum="CE2ECA1880F3153E" modified="2018-10-10" version="1">MADDELEEVLALAEDEELCASLLLLSVLEHAANASKSEPDTSTLVSARRADRFVVGIVNLTSVTGITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYD7</accession>
    <name>A0A2Z5QYD7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87478">
        <property type="protein sequence ID" value="BAV87478"/>
        <property type="gene ID" value="RA11412_1179"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1179"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LIGANc" evidence="4">
        <location>
            <begin position="6"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="256" mass="28191" checksum="3A8FD9B8975EDC7B" modified="2018-10-10" version="1">MSLTPEIRDEYAQLIDDVRDARRAYYTDDAPTISDAAYDALYRRLEEVEALYPELVANDSPTQEVGGEASSAFAPVTHRARMYSLEDVFSDEELRAWLTKAQENSQAISGKNPTWLTELKIDGLAVNLLYRNGALVRAATRGDGTTGEDVTHNVRTIATIPQRLSGQNHPEEIEIRGEVFISSADFKALNEKIVAEGKNPFANPRNAAAGSLRQKDAAVTAQRPLSMYVHGIGSSQGLGIETQSEVYELLASWGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYF4</accession>
    <name>A0A2Z5QYF4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87376">
        <property type="protein sequence ID" value="BAV87376"/>
        <property type="gene ID" value="RA11412_1077"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1077"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="124" mass="13145" checksum="A53ECADDB9C8D249" modified="2018-10-10" version="1">MSEDRQNVDTAAEPDEKGWEALRPAVKYPVAEGALDEAPAADSPQEDVQDTQPETQTGAFARIRAEAPGTAAEPDVATGAVPIAPARSKLGERGVGQRVRTYTSVSTGFIPLVREVHNAPRVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYF7</accession>
    <name>A0A2Z5QYF7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="18" type="ORF">I6I94_03250</name>
        <name evidence="17" type="ORF">RA11412_1208</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87507">
        <property type="protein sequence ID" value="BAV87507"/>
        <property type="gene ID" value="RA11412_1208"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1208"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013173">
        <property type="entry name" value="DNA_primase_DnaG_DnaB-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08278">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="261"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="438"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="441"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="BAV87507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QQT89639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="656" mass="73407" checksum="70EEE4312D7D73DD" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYK7</accession>
    <name>A0A2Z5QYK7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">D-serine/D-alanine/glycine transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Proline-specific permease ProY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">proY</name>
        <name evidence="11" type="ORF">I6I94_03085</name>
        <name evidence="12" type="ORF">NCTC10207_00659</name>
        <name evidence="10" type="ORF">RA11412_1249</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87548">
        <property type="protein sequence ID" value="BAV87548"/>
        <property type="gene ID" value="RA11412_1249"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1249"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="9">
        <location>
            <begin position="34"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VEI22578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="473" mass="51092" checksum="0D8C0E802B4D0D31" modified="2018-10-10" version="1">MKNTDSTDRNPTPVDTAKVQPGTPHLQRVLTLRHIMFIALGSAIGTGLFYGSASAIQLAGPSVLVAYMVGGAAVFMVMRAMGELALANPVSGAFSEYATRYLGRWAGFVTGWSYALEMALVAIADVTAFAVYMQFWFPNSPAWVWIVSVLLILLAINLTKVKAFGEAEFWFTLVKVSAIIAMIIGGVILLFVGVQAHDSVAPSVTNLWSLDGGFMPNQFTGFLACFTVVMFSFGGIETIGIAAGETKNPRVSIPKAIRTVPARIMIFYVLTLGVIMSLYPWYSVSKENSPFVQIFSSLGIPAAAGILNIVVITAAVSAMNADVYGAGRMLYGLAQRGLAPASFRRVSRNGAPWMTTLLMIVVMAVGVIVNVLFKDAFEVVASLATFATVLVWVMILLAHIAYKRGGYDTEKQPVRLPLWVSYLTLVFMAFVVVLLGLFESTRLALVVGGVWCVFLLGYYLLVLRGKQPGVTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYK8</accession>
    <name>A0A2Z5QYK8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosylaminoimidazole carboxylase ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87371">
        <property type="protein sequence ID" value="BAV87371"/>
        <property type="gene ID" value="RA11412_1072"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1072"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurK_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="73" mass="8062" checksum="A8B71E687817CCFC" modified="2018-10-10" version="1">MKNYLGGEHDDIFGVYPLAFSAEPRAKIHFYGKEPRPGRKIGHVNVTGGAHELEQLRHIAANAASILRDGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYL4</accession>
    <name>A0A2Z5QYL4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03490</name>
        <name evidence="2" type="ORF">RA11412_1144</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87443">
        <property type="protein sequence ID" value="BAV87443"/>
        <property type="gene ID" value="RA11412_1144"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1144"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="311" mass="34314" checksum="FEE73ED8C93AC39C" modified="2018-10-10" version="1">MLQFESRIPSVSVVIATNGKRMQSLRTAVTAILDQQYPGPVEVVIVYDRVTPDPLSDIEISENRSLRIIENTRTGGLAGARNSGILEATGIILGFCDDDDTWMPGKLTEQVALWRANPDAVGISSGITVRSDGRNIVRLAPERATFDDFLRSRITEVHPSAMLYSRSDLVDGPVGLVDEQLPASYGEDYDLLLRATKHGDILSVPQPLVRVLWDRPSFFAGQWQYIADGLTYLLRKFPEFERYPKGVARVAGQVAFAHAALGHKKEAFAFARSSLHRDKTQLRAWAAYPVALGVVKPQTLLDAVQKTGRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYQ4</accession>
    <name>A0A2Z5QYQ4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polysaccharide biosynthesis protein CpsF</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">UDP-N-acetylglucosamine--LPS N-acetylglucosamine transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_03505</name>
        <name evidence="7" type="ORF">RA11412_1141</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888063.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87440">
        <property type="protein sequence ID" value="BAV87440"/>
        <property type="gene ID" value="RA11412_1141"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1141"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="PTHR12154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="157" mass="18106" checksum="FADB9BFE7C9277F6" modified="2018-10-10" version="1">MERLRKKPSKLLLVSSSGGHLKHLTATFDAWQNYERVWVSFKQPDVESALAEEKVYWAYYPTTRNVKNAIRNLFLAFKIFPRERPDVVVSAGAGVAVPFFVAAKLFRAKTLYIECYDRPTLPTMTGKMLYVLADDFNVQSDEQQKNFPDSRVIHPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYQ7</accession>
    <name>A0A2Z5QYQ7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87374">
        <property type="protein sequence ID" value="BAV87374"/>
        <property type="gene ID" value="RA11412_1075"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1075"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="141" mass="15032" checksum="F3AE3EA7F28FD783" modified="2018-10-10" version="1">MRYTGDSEAVFNVYDGEILDFCALVRSEADQFMGMPPHPTTEVLAGVTNADVLAEILKQARSFDSHQVRLDSGEPALAVLLNSQHSFGTPENALAIVCEVLGALVAGYAVLITDPTAGFTPAEIAPILASERAVDTRRQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYV2</accession>
    <name>A0A2Z5QYV2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03600</name>
        <name evidence="2" type="ORF">RA11412_1115</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87414">
        <property type="protein sequence ID" value="BAV87414"/>
        <property type="gene ID" value="RA11412_1115"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1115"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="435" mass="47935" checksum="651875BE600DAB67" modified="2018-10-10" version="1">MSVTSSKVANGQPASAAERIQNHLGQGTEYLRQGAGKIRLPEFIMFFLMIFGEAVPGVGLPYHQVVIIVIVLYALIKQPVYELGKFQNLAFATFAALGYLAFVSLTHESSSGAFDWQRRLLRLLLATLLIWIIASGRIHIRSAIAGYVTALLVNVPLYYAGLTPDNYKGYLTGHLLDKNVSGLAYCIFGLLALALARRRAEIILTIIVFAAFLWLTGSRTSMAAFAMGIIWIVLAKRLPAWGRLILGLLIYLALGILTEDYSQSSQFGNRAGSDWFRTQIDAASQVKVENTGIFGRGLGEAYVYLQHDNKVWLFHNSYWSALVEGGWPWMLLVVGISVFCLVRPFSNASQWSRDEVYIQGAGIALLVCAQRLGEVFYTWMWAVCVGYAIRAIIISRAVGTIHEHPGDKDGIDGRIPLTKKTLLTSPAAGAPEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYW7</accession>
    <name>A0A2Z5QYW7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperone protein DnaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87657">
        <property type="protein sequence ID" value="BAV87657"/>
        <property type="gene ID" value="RA11412_1358"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1358"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="282" mass="30786" checksum="CB763313145DC562" modified="2018-10-10" version="1">MASLREKAEFAKKALSTVPKTNVQFSANDQHYRVPLTREEFNEVTQSLMVRTQELVADVLEASKLTWDDIDKVLLVGGSTRMPAVRELVEQMSGKSPELDVNPDEAVALGAAIQATLEGDIEVSTEQVGSKATVESFLGGPVHISDVTSQALGVILIEADGVTEFNQVMIERNTKVPAKTELKTKTAYDRQTAVHVKVTQGDERDPQNVTIVGEGQLEIPVYPKGSPLRVSYEYDVDQTVVVEVYDLTANKSLGTIKIERVANLGEGELGEMEQKIGGMQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYY5</accession>
    <name>A0A2Z5QYY5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87678">
        <property type="protein sequence ID" value="BAV87678"/>
        <property type="gene ID" value="RA11412_1379"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1379"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="58" mass="6803" checksum="C0CD7E176C5CC213" modified="2018-10-10" version="1">MRSVSDHTVTDASHRYFLQHVSASVEFKWLTRSYHVATLDYDAELVKEFTHKFVQSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYZ2</accession>
    <name>A0A2Z5QYZ2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I6I94_03190</name>
        <name evidence="10" type="ORF">RA11412_1221</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87520">
        <property type="protein sequence ID" value="BAV87520"/>
        <property type="gene ID" value="RA11412_1221"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1221"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="292" mass="30481" checksum="30333BAA4EC3DC68" modified="2018-10-10" version="1">MTAEPESTGESPSLPQVKPTSKAGRDLPAAIGVGVAFGVLLLLGLFFPPVMVFTAALTAGVGAWEVAHVLNDKRGHGIPAVATGVLTVMTVVASYIHGVLGLVICTAVSAVILLVWTLLLSGRRRTANIPAATFGVLGTLLWVPVLMSIPIVYLGSVERGWLGILMILLMAISNDTFGYIAGVNWGRHPMAPKISPKKSWEGLAGSIIGSALVAIVTLIIVGQPWWYGLLVAPVMVVASTAGDLMESVVKRRLGVKDMSNILPGHGGMMDRLDSILFAAAAGCLIFGTVMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ20</accession>
    <name>A0A2Z5QZ20_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">RA11412_1242</name>
    </gene>
    <organism evidence="2 4">
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        <lineage>
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    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT89618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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            <end position="28"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="60"/>
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            <end position="91"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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            <dbReference type="EMBL" id="BAV87541.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="QQT89618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="123" mass="13820" checksum="F82A0DCCE0F5CA6D" modified="2018-10-10" version="1">MIAGLDWWFWVTAVLGSLSAAAALVQYVRGYAPDDYSQGPVLLLEAYLVVYLIGSIIMQAVGPGPRGDWLEYYGYLLTAMVIPAGAFFYSLSERTRWATLLLAVPGPVLIVMVHRMNMLWYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ52</accession>
    <name>A0A2Z5QZ52_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyphosphate glucokinase</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1418</name>
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    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87717">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ATPase_NBD"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="300" mass="32249" checksum="A1FB3CDA23623CA8" modified="2018-10-10" version="1">MSKSTAANSAAEESVEYVDIPAPTPKDLMIGIDIGGTGMKGGIVDLRTGNLVSERFRIPTPQPATPQAIAQVARQIVDELQSRDLAPEPHSAIGVDFPAVVKNGVVFSAANVDPTWINTNLEQLISDALDSRAVYGINDADAAGLAEATYGQGRDKMGLIAVITLGTGIGSALINNGVLVPNTELGHLEIDGHDAESRASARAREVHELSWKKYASKRLRRYFQHVEALFSPTFSLSAVVSRRTPKSSCLILRTRFAPPWSWQPCAIMPVLWGRHCGLAVCCPNVNAAGRRKEPAEKTCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ59</accession>
    <name>A0A2Z5QZ59_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional repressor AcnR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">acnR_3</name>
        <name evidence="5" type="ORF">I6I94_02290</name>
        <name evidence="6" type="ORF">NCTC10207_00833</name>
        <name evidence="4" type="ORF">RA11412_1443</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87742">
        <property type="protein sequence ID" value="BAV87742"/>
        <property type="gene ID" value="RA11412_1443"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1443"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VEI22748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="205" mass="22809" checksum="E3E1A8735D7977D9" modified="2018-10-10" version="1">MSSPKKNPKPRRGPRAGGVERKHILQVATELFSEHGYQATTMRKIGTAAGVDAKLIHYYFGTKEDLFTAAISEVFRSRGLPDILSEYRPEATDSPGTHYIRAVLTTLETPTIGPAFTGLLRSLGTHEESQKVFLRFVNEELLERLAPQLPVENATTRLALAGTQIFGLIYTRYILKIPPLTELSIEQTARLIGPTLDTYMRGPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZA4</accession>
    <name>A0A2Z5QZA4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">murF</name>
        <name evidence="13" type="ORF">I6I94_02490</name>
        <name evidence="12" type="ORF">RA11412_1394</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87693">
        <property type="protein sequence ID" value="BAV87693"/>
        <property type="gene ID" value="RA11412_1394"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1394"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="118"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="334"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="508"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="120"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV87693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT89513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="538" mass="56215" checksum="C76182BA71E2A766" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZB2</accession>
    <name>A0A2Z5QZB2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_02795</name>
        <name evidence="8" type="ORF">RA11412_1321</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87620">
        <property type="protein sequence ID" value="BAV87620"/>
        <property type="gene ID" value="RA11412_1321"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1321"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="200"/>
            <end position="613"/>
        </location>
    </feature>
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        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="221"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAV87620.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QQT89562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="767" mass="84212" checksum="41FE161226CE612B" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZD6</accession>
    <name>A0A2Z5QZD6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arogenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87640">
        <property type="protein sequence ID" value="BAV87640"/>
        <property type="gene ID" value="RA11412_1341"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="111" mass="11157" checksum="F65C8EADA6911048" modified="2018-10-10" version="1">MGSQDISPVLTGPVLVIGTGLLGASIGLGLRAAGVPVYLQDISPTVEAVAEDIGAGTRWSSLGEAKRASCAPQLVLVAAPPDVAGDLCVQALNTYAPHGDYPGPPSLILLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZH8</accession>
    <name>A0A2Z5QZH8_9MICC</name>
    <protein>
        <submittedName>
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    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="125" mass="13845" checksum="9D0EE9F5C642469E" modified="2018-10-10" version="1">MTEQHLTNSIDLAVIAGDGIGPEIIAQARRVLDRVCELDSIAVTSTDYSLGAEHWLKTGETLPESTMDALKKHDAILFGAIGADPRSGDIPSGLIEREMLLKLRFAFDHYINLRPARLYPGRCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZJ3</accession>
    <name>A0A2Z5QZJ3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division protein FtsI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87690">
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        <property type="gene ID" value="RA11412_1391"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1391"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
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        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="63"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="283"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="385" mass="42433" checksum="00C70EF9A0C02F5A" modified="2018-10-10" version="1">MAHKKKAVSSQSERKLSRRGFMIGASSTGLLGLLSLRLLYVQGLDPQNLAATSRDSRTRTQKVPAVRGQITDVNGHVLARSVQRYNIIADQTIVAEFKRYDHSQERVTVTPTELVYEVTDILRTVDPTITDDFVKSKLEGDSRYSVIKTNVTPEIYNRIDALGAPFLFGEVISERLYPDGPVGGSVVGRYRIVDEAVEGKENETVERNLSVGIERTFEKELAGVNGKRVYEIGADGVRIPVTQEQVSESVNGKTVRLTLNRDIQYYAQQVMKARVDELKAEWGCAIVMDVRDGSILALADSTTMDPGAEKVENTQDMVPRAISQIIEPGSTEKILTASALIEKGITTPPIHMMCPPPSPLTGKPSKMLLSTPRNAARSRVLLPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZU7</accession>
    <name>A0A2Z5QZU7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excisionase/Xis DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87734">
        <property type="protein sequence ID" value="BAV87734"/>
        <property type="gene ID" value="RA11412_1435"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1435"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="79" mass="9286" checksum="69E7BBBBD79137B0" modified="2018-10-10" version="1">MYAPLETILRAQLEHKAVTLVQQDRMMTTQEAADYLGMSRPTLVRLLEDGKIPFEKLKKHRRVAFADVETYRAHRMNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZV4</accession>
    <name>A0A2Z5QZV4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
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            </authorList>
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">JCM 11412</strain>
        </source>
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            <dbReference type="Proteomes" id="UP000250241"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="BAV87966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A2Z5R0F0_9MICC</name>
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            <fullName evidence="2">Excinuclease ABC subunit C</fullName>
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                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <name>A0A2Z5R0G3_9MICC</name>
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    <reference evidence="1 2" key="1">
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="protein sequence ID" value="QQT89271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="QQT89271.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="754" mass="85379" checksum="D73848F24D4EE4E6" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0L9</accession>
    <name>A0A2Z5R0L9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-demethylubiquinone-9 3-methyltransferase</fullName>
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        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07730</name>
        <name evidence="2" type="ORF">RA11412_0110</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86409">
        <property type="protein sequence ID" value="BAV86409"/>
        <property type="gene ID" value="RA11412_0110"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0110"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="136"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="282" mass="31511" checksum="37C697952A073D51" modified="2018-10-10" version="1">MDQVITPAMWCDGTADEAAQFYADVFRDTSIAEQAPGIVTTVSIHGFRLSLINGGNQYAPNPSISCILNFDPLLFGGEEQARDYLDELYERLSTGGVLMELGEYPFSPRYAWVRDRFGMTWQLMLTDPDGDPRPFVIPSFMFGGTNHANAEEATDAWIALFDNARRGALYRYEEGGPLDAGTVMFTDFTLRGTWMAATDSGTFHDFTFTPGVSIIVSCRDQEEIDRYWAGLSAVPEAERCGWCVDRWGVSWQVVPHNIAELMANATTRDKILHMGKIDLTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0N3</accession>
    <name>A0A2Z5R0N3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">DUF349 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00470</name>
        <name evidence="2" type="ORF">RA11412_1904</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88203">
        <property type="protein sequence ID" value="BAV88203"/>
        <property type="gene ID" value="RA11412_1904"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1904"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007139">
        <property type="entry name" value="DUF349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03993">
        <property type="entry name" value="DUF349"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="338"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="423" mass="47897" checksum="107DEBEEE42B678E" modified="2018-10-10" version="1">MTIKSDDIAVNLEKARKFGRVSEDGHVFVIVEGEEYAVGQLPDASEEEALAYFARKFENVEAQVTLLESRIENNAPAADVQKGIESIGAQIAERNMVGDYAGMQQRLTALTERIGELAEQQKQNRAANRERALAAREEIVAEAESIVEQDPEKIHWKNSHARMNELFDAWKQAQREIHLPKSVEDELWKRFRTARTTFDRNRRAHFSQLDERNARIKRAKEELISRAEELSSSTNWSDTSRAYGDLMREWKKVPRGSRREDDKLWARFRAAQDVFFDARNAAEAEQDAAYADNLKVKEALLVEARGLLPVTDIAAAKAAFDKILDRWDAAGRVPRADMRRIDSELRKIQDEIHGAEAAKWKKNDPAKTARANSLLAQIQDSLTKLETELAQAQASGDEKKIAKAQEALDARRAWAATLEGFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0N6</accession>
    <name>A0A2Z5R0N6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Transaldolase</fullName>
            <ecNumber evidence="6 7">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tal</name>
        <name evidence="8" type="ORF">RA11412_1747</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the transaldolase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="6 7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88046">
        <property type="protein sequence ID" value="BAV88046"/>
        <property type="gene ID" value="RA11412_1747"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1747"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00955">
        <property type="entry name" value="Transaldolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00493">
        <property type="entry name" value="Transaldolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004732">
        <property type="entry name" value="Transaldolase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036915">
        <property type="entry name" value="Trnald_Bac_Plnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00876">
        <property type="entry name" value="tal_mycobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="306" mass="33230" checksum="096DB07E73918504" modified="2018-10-10" version="1">MSDLAASGADVEEAVFAATTDDVRAACDVFKPIFEASQGFDGRVSIEVDPRLARDAEGTKKMARELYERVSRENVMIKIPATVEGLEPIAKTLAAGISVNVTLIFSLTRYREVINAYMLGLEEALENGKDLSKIHSVASFFVSRVDTEVDAQLSALGTDEALALKGKAGVANARLAYEVFEEMFSSERWKRLERKGANVQRPLWASTGVKDPALPDTLYVTGLVAPHTVNTMPEATLNAVADHGEVVGDTVRASYAESNEVLDAIERAGVSYREVVEKLEAEGLSKFDASWEELLDTVRGALQNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Q5</accession>
    <name>A0A2Z5R0Q5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat shock protein 60 family chaperone GroEL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86449">
        <property type="protein sequence ID" value="BAV86449"/>
        <property type="gene ID" value="RA11412_0150"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0150"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="98" mass="9804" checksum="76A45AAF827C633D" modified="2018-10-10" version="1">MAIDAPLKQIATNAGLEPGVVVDKVRSLPEGTGLNAATGEYEDLMAAGINDPVKVTRSALQNAASIAGLFLTTEAVVANKPEPASAAAPAADPMGGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0S5</accession>
    <name>A0A2Z5R0S5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88338">
        <property type="protein sequence ID" value="BAV88338"/>
        <property type="gene ID" value="RA11412_2039"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2039"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="53" mass="6105" checksum="1D00E409B11F25BE" modified="2018-10-10" version="1">MTISSLFFQLGVAVFAMLGFTSDAAVDYTASRNFRLRNLEKIREKVRRKAIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0W2</accession>
    <name>A0A2Z5R0W2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloalkane dehalogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88377">
        <property type="protein sequence ID" value="BAV88377"/>
        <property type="gene ID" value="RA11412_2078"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2078"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="100" mass="10577" checksum="56D3AC81055D9031" modified="2018-10-10" version="1">MAAEQSAETLDEVRRAALVAVGPDGAAAAVLVIEATDRALKQGQAPLALSRAVRERVKEDTGIELAAVLVVREHPTDIRHNSKIDRTALSTWAQKVLAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0X3</accession>
    <name>A0A2Z5R0X3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88190">
        <property type="protein sequence ID" value="BAV88190"/>
        <property type="gene ID" value="RA11412_1891"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1891"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="177" mass="19406" checksum="26FCF390B36A0C1B" modified="2018-10-10" version="1">MGVDVGNARVGTALSDPDGILATPLKTLRRDHKKNSDRRVLRKLAEVNDVVEIFVGLPKTMRGGESASTVMAKEYAENLRSELDAEGREHIHIWLVDERLTTVSAQRSLHEAGVSSRDFKAIVDQAAAVNILQYCLDTLKSGYAIAGYKLSSPAYEEAHSEECPLDGKPVNETETLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0X4</accession>
    <name>A0A2Z5R0X4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88435">
        <property type="protein sequence ID" value="BAV88435"/>
        <property type="gene ID" value="RA11412_2136"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2136"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="218" mass="23393" checksum="5DC90185A30F8E26" modified="2018-10-10" version="1">MQASAFSDPHAKFPSTLRELAQEYLGRIRQTLRDADLPARIELMGWSVGGTAAVEVAALAEDAGIAVERTVLLDAYPAEQWQGVPAPDEQESFRALLRMGGLPEAAPGEVLDLPGTLRRLRQAGSAMGHLPEDKLGVCLESMRASAALMRGAQQLDFSGAVTMFSVPHEDQPYLDAHGWENHAGSLRVVRVDGTHPDMVNPAYIPQIVAEAFGSGPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R143</accession>
    <name>A0A2Z5R143_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86599">
        <property type="protein sequence ID" value="BAV86599"/>
        <property type="gene ID" value="RA11412_0300"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0300"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="101" mass="11262" checksum="8977B850D6C6C1D4" modified="2018-10-10" version="1">MHGWRCGHGGSFCSGVFRVVSVVARRARRLWLVFCCLFVPVYRVGVWVWVFPGGAGVLWWGSALLLGGVRLVAARVCAAAGRQGPVSPCLWWVCLIFLWWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R172</accession>
    <name>A0A2Z5R172_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-isopropylmalate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88234">
        <property type="protein sequence ID" value="BAV88234"/>
        <property type="gene ID" value="RA11412_1935"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1935"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LeuA_dimer" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="93" mass="9819" checksum="0F895CC54EF83F11" modified="2018-10-10" version="1">MTLNVEGRTYNRTGTGTGPVDALQNVLSAEGVDIRVMDYSEHTLSSSSAANAACYIEAAVDTRVLWGIGIDSSTTRAALKAMISAVNRALRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1B2</accession>
    <name>A0A2Z5R1B2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pilus assembly protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative TadE-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_10340</name>
        <name evidence="2" type="ORF">RA11412_2276</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88575">
        <property type="protein sequence ID" value="BAV88575"/>
        <property type="gene ID" value="RA11412_2276"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2276"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="139" mass="14788" checksum="843CC6D54607DF95" modified="2018-10-10" version="1">MTRRRGKEGTGADADRGDASTDFVMVSALLALITVAILQVSYAFYVRNLLLDAASAGARYGTLHDRNPSESVDRTSEIIRGSLPGNYAQNVSYSESFNSAGARVLEVNVSAPLPVLGPFGLPNSLSVKAHAVYPVQTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1C6</accession>
    <name>A0A2Z5R1C6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">rsfS</name>
        <name evidence="4" type="ORF">I6I94_00135</name>
        <name evidence="3" type="ORF">RA11412_1995</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887352.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88294">
        <property type="protein sequence ID" value="BAV88294"/>
        <property type="gene ID" value="RA11412_1995"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1995"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="143" mass="15627" checksum="BD5A1A921BE10D33" modified="2018-10-10" version="1">MTAAPASIEALRIAARAAEEKQGTDLFAVDASDAMGLIDGFLVVSAHNERLVNAVADGIEDALREQAGMKPVRREGRASGRWILLDFGDIVIHVQHEEDREFYALDRLWSQAPRIELGVKTETPFDIAGETEEDAARIIPADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1C7</accession>
    <name>A0A2Z5R1C7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rplU</name>
        <name evidence="7" type="ORF">I6I94_00105</name>
        <name evidence="6" type="ORF">RA11412_2002</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887214.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88301">
        <property type="protein sequence ID" value="BAV88301"/>
        <property type="gene ID" value="RA11412_2002"/>
    </dbReference>
    <dbReference type="GeneID" id="29742944"/>
    <dbReference type="KEGG" id="raj:RA11412_2002"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT90031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="103" mass="11098" checksum="85C4A3976EBCDC62" modified="2018-10-10" version="1">MAYAIVRAGGRQEKVSVGDKITLDRVAGEPGSTIELPVLLLVDGDKITADAKSLASAKVTAEKIEDLRGPKIVIQKYKNKTGYKKRQGFRAELTTVKITAINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1E4</accession>
    <name>A0A2Z5R1E4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6318 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88314">
        <property type="protein sequence ID" value="BAV88314"/>
        <property type="gene ID" value="RA11412_2015"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2015"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="DUF6318"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6318" evidence="2">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="199" mass="22358" checksum="16300EC54E596246" modified="2018-10-10" version="1">MDPAQFIADWQKYTGDAKLPTKGDNGYVPATGSSPAQNVPEPDINEEASRKNTLEGSYQTLLAFQSAFNYLSLTGKDEPIKKLIFPQDFSMKLEVEKHHSLYSSKGWIEGYNRSVKISDHRPAVAFSDTVIGVSWYFSESYEKFIVHQAGGTNEEVPARTSEGIMTTIYENGVWKVISNDYLKQHYSYLTSQGREKGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1F9</accession>
    <name>A0A2Z5R1F9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88331">
        <property type="protein sequence ID" value="BAV88331"/>
        <property type="gene ID" value="RA11412_2032"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2032"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007331">
        <property type="entry name" value="Htaa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
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        <property type="entry name" value="HtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016232923" evidence="1">
        <location>
            <begin position="48"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="234"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="296"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="362"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="412" mass="45315" checksum="C8403FCECB3736EE" modified="2018-10-10" version="1">MRYTTHANIQHNHTGVLHRRGHRICTATAAVLLTASTSILTPTPLLASPTQQVPAPAAQTATTNNDHTITNGTINWGVMPALREYASNPYVSAVLDLTDVTHNDKGEFIWKNGTGSYTNGSGTIMIPGVLSLRSNHSQLNMRFSRVRITISDSGASGKITLDATISTLDGQRKTYTNVDFATINTENLKVADGRISLDKAPLTMTDDGARIFDGTQLLPQNRELDPITLNAPLTHPTFSDVPAGSHLQPEIEWLAASGITTGYPNGTYHPHESVERAAVAAYFYRLAGSPAVTLPQESPFIDVPTDHPFYKEIVWLHRRGITTGYPDGTFRPNAPINRDALAAFFYRAAQEPDYTPPAVSPFADMAPHDGFYKEIAWMHSQNIAHGWPDRTFRPLQPVQRDAMAAFIYRMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1M6</accession>
    <name>A0A2Z5R1M6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="4 8">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_2127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="4 8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88426">
        <property type="protein sequence ID" value="BAV88426"/>
        <property type="gene ID" value="RA11412_2127"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2127"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="9">
        <location>
            <begin position="187"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="484" mass="51808" checksum="613D139850216321" modified="2018-10-10" version="1">MTENIESKKAQIGVTGLAVMGANLARNLARNGYTVALHNRSVEKTDALLAEHGQDGEFIRTESLQQLVDSLESPRRILVMVKAGAPVDAVIEQLTPLLDEGDIVIDGGNSHFPDTIRRERELAQKGLHFVGVGVSGGEEGALWGPSIMPGGSAQSYHHVGPMLEKISAKAPQDGSPCCAWIATDGAGHFVKMVHNGIEYADMQVIGEAYDILRSIAGLEPAEQAQIFKTWNETELNSYLIEITSEVLAQVDAKTGKPLVDVILDQAGQKGTGRWTVQAGLDLGAPVSAIAESVFARALSSSDPVAREQAQQQLPAGLIATTGVGAGDPEFVEDVRRALLASKLVAYAQGMDMIARAGDEYGWDLKLDVIASLWRAGCIIRAELLGDIMAAYSGERPANMLLAPQFKSLMDELVPSWRRVVGKATALGVPVPVFSSALSYYDGLRRDRLPAAVIQGQRDFFGAHTYGRVDEEGPSTLCGVVTVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1N3</accession>
    <name>A0A2Z5R1N3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88647">
        <property type="protein sequence ID" value="BAV88647"/>
        <property type="gene ID" value="RA11412_2348"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2348"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="149" mass="16692" checksum="3288DF3B68583033" modified="2018-10-10" version="1">MAEPAIQKHLTLLTGSAENYRVCERIVAQCWYGSPPINAKTAQETLHRIDWDDEDTPLNDEPATQGCLEMLTAISSMLGGLRAGRKDSAYFANCAENVINWKDTLACFPASADGTPEQQDLLQEYERQHLFLRELGEGHIGAEDIHKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Q3</accession>
    <name>A0A2Z5R1Q3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type enterobactin transport system</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_10870</name>
        <name evidence="8" type="ORF">RA11412_2145</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888694.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88444">
        <property type="protein sequence ID" value="BAV88444"/>
        <property type="gene ID" value="RA11412_2145"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2145"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="369" mass="38142" checksum="C2549880B561EEBD" modified="2018-10-10" version="1">MATPPTINIVKSADSQQAPTKRRNRSRSLGGKAVVTLRGPIAAQIPWRVVILNSVLVAVIFCLSIWALMQGDREYSAFQVIDTLLGGGTRSSRIFVPLRAARIVAALLVGAALGLSGAIFQVISGNTLGSPDIIGFTNGAATGALLQIIVFNSGPVEVAAGAVIGGLATSLLVWLMTRHTGLRGFRLVLVGIGVGSTLAALNSLLVVRASLTQAQTAASWLAGSLNDIVWERSFALMIAMALVVPALLLVTRPLGAIRFGDNVAAGLGVSVNRYRVAALFIGVLLVSLATATTGPVAFVALAAPHIAKTLTKTTGVGFTSSALMGALLVFGSDLIGRYAIPGGMQVGVVTGAIGGLYLMYLIYLERKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Y7</accession>
    <name>A0A2Z5R1Y7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88622">
        <property type="protein sequence ID" value="BAV88622"/>
        <property type="gene ID" value="RA11412_2323"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2323"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="72" mass="8405" checksum="376EA68C1A3A72CD" modified="2018-10-10" version="1">MLNGWMMRVSDRWASQRCFVSVRNIGLQYWVKDLHEAASVSADMILPCGTPPRADDEKVFIYCRRTRRRAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Z5</accession>
    <name>A0A2Z5R1Z5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5-Enolpyruvylshikimate-3-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88564">
        <property type="protein sequence ID" value="BAV88564"/>
        <property type="gene ID" value="RA11412_2265"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2265"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="298" mass="31549" checksum="4770E481A2D7AB23" modified="2018-10-10" version="1">MAQRPVEGSAIPEVCIDASASSQFVSAFLLVAPRLPQGLVIRHVGDAVPSVPHIEMTVETLRELGVRVESSPEQYTWVVRPGAIRGFEKTIEPDLSNAGPFLAAATVTGTSVTIPDWPAPAGDGQPGTTQGGDMWRELLPTVGATVSYSEKGLTVTGSPAVGGEREYVFDLARCGELAPTLAAICALLPARTELRGIAHLRGHETDRLKALRVEINRLGGSADELDDGLVIDAPVQRAATNAAVTVRTYEDHRMATFAAVLGLRVPGVVVENIATTAKTLPDFVGLWNNMLGQLEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Z9</accession>
    <name>A0A2Z5R1Z9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_2333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88632">
        <property type="protein sequence ID" value="BAV88632"/>
        <property type="gene ID" value="RA11412_2333"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2333"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
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        <location>
            <begin position="94"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="700" mass="78206" checksum="853C4C2E1AE17A15" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R213</accession>
    <name>A0A2Z5R213_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galactofuranosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2285</name>
    </gene>
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        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="193" mass="22443" checksum="489E2B083E1BB9CC" modified="2018-10-10" version="1">MQYYTEAGRLMALEDLLSGPEHLHESLSARLPQIRAMAAEYPESQVKTDVDSFPTIKNKKPPFRGRRNFKSPGYKKLVPWTMNTLRRQLTKPMTGELKSHPQIQLNYGESNWWTLSRFDSALATNAEGTGLFWYRRDPKQVRSKLIDATKLHARLLKEWPTLRERYRNASASVASYEAWAETFAKHTESELKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R222</accession>
    <name>A0A2Z5R222_9MICC</name>
    <protein>
        <submittedName>
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    </protein>
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        <name evidence="3" type="ORF">RA11412_0640</name>
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    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86939">
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        <property type="gene ID" value="RA11412_0640"/>
    </dbReference>
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    </dbReference>
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        </location>
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            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="538" mass="59781" checksum="48916CCD35326D06" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R223</accession>
    <name>A0A2Z5R223_9MICC</name>
    <protein>
        <submittedName>
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        <submittedName>
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        </submittedName>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_10265</name>
        <name evidence="4" type="ORF">NCTC10207_01546</name>
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    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 5">JCM 11412</strain>
        </source>
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    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006889133.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88594">
        <property type="protein sequence ID" value="BAV88594"/>
        <property type="gene ID" value="RA11412_2295"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2295"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DNA-bd_dom_put_sf"/>
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    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAV88594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI23438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="78" mass="8816" checksum="59C0BA5CD8840650" modified="2018-10-10" version="1">MTAPRFLTLSDVADELQVSLSQVRALVRSGELPAIQIGGRNQWRIERTRFEEYIDERHSQTVEAIASGKMSATRVKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R230</accession>
    <name>A0A2Z5R230_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lon-like protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88620">
        <property type="protein sequence ID" value="BAV88620"/>
        <property type="gene ID" value="RA11412_2321"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2321"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
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        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="69"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="181" mass="19449" checksum="466AAF89B9A726B1" modified="2018-10-10" version="1">MTTVSVSGGPYTPLSGIEAINGWASLDGKQYLVVPTEILYPRVSNDQANSASTSQMADSQTQAQVAAAHYLKIPVTETVTVLQTVEKSPAEGVLKGGDRILKVNDEPLKGYKSMVDATQASEGKPIKLTVERDGAQQEHTLTPVKDEESGRWRVGVALKQDYEIPAKIKYHTEGWAAPAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R235</accession>
    <name>A0A2Z5R235_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_09595</name>
        <name evidence="7" type="ORF">RA11412_2454</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023134159.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88753">
        <property type="protein sequence ID" value="BAV88753"/>
        <property type="gene ID" value="RA11412_2454"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2454"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="10"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="253" mass="27365" checksum="A367B74D72805F02" modified="2018-10-10" version="1">MLRYTLYEIRRSVLSFSSLFYTIIMPVGLYLLFGALQDYAKIKVADGNAAAYVMIGIALYGAISCTVSISGLTVVENVAGWGRQLGLTPMNTGKYLLSKCCVAFIMAAVPITAVNIVARMTKIDMPLKQQIACAALSILCAMVFGFFGLAIGFLVPSESAVGIANGILVVFSFFGTLFAPLTKDLMPYARFTPLYGAAEIARYPFSKGLTIISGSGAEWNMTEPLWYGIVNFSVWTVIFVVATALLMGRSTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R275</accession>
    <name>A0A2Z5R275_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_10335</name>
        <name evidence="3" type="ORF">RA11412_2277</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006889161.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88576">
        <property type="protein sequence ID" value="BAV88576"/>
        <property type="gene ID" value="RA11412_2277"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2277"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340106" evidence="2">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="78" mass="8237" checksum="41E415FAF9F44E4A" modified="2018-10-10" version="1">MFRRIRTSLALLTALAMTALVAGRVFGSRSGSDDPERGDVPGWVMITMMSAVLVAAILAVAQPALTTMFNDAIAKVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R278</accession>
    <name>A0A2Z5R278_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86999">
        <property type="protein sequence ID" value="BAV86999"/>
        <property type="gene ID" value="RA11412_0700"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0700"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="43" mass="4825" checksum="9688CB6C78182934" modified="2018-10-10" version="1">MPAHPNEILDARARLCLHAELLETVRHRLANPQPGVKVSLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R286</accession>
    <name>A0A2Z5R286_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">rpoA</name>
        <name evidence="14" type="ORF">I6I94_09240</name>
        <name evidence="15" type="ORF">NCTC10207_01753</name>
        <name evidence="13" type="ORF">RA11412_2539</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="14 18" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037234581.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88838">
        <property type="protein sequence ID" value="BAV88838"/>
        <property type="gene ID" value="RA11412_2539"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2539"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="12">
        <location>
            <begin position="18"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="11">
        <location>
            <begin position="247"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV88838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT88697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VEI23825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="330" mass="35549" checksum="AE05E36698F66CEC" modified="2018-10-10" version="1">MLIAQRPTLTEEVVAPNRSRFTIEPLEPGFGYTMGNSLRRTLLSSIPGAAVTSVRIDGVLHEFSTIAGVTEDVTEIILNIKKLSISSENDEPVVAYLRLQGEGELTAGDIEVPAGVEIHNPDLHIATLNDKANFNAELTIERGRGYVSAAQNKIGDAEIGRIPVDSIYSPVLKVTFNVNATRVEQRTDFDSLTLDVETKEAIAPRDAVASAGSTLVELFGLARELNVAAEGIEVGPSPVDESIAADMALPIEDLNMSVRSYNCLKREGIHTVGELVTRSEADLMDIRNFGAKSIDEVKAKLHELGLALKDSPPGFEPVVRAFDDEDGSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2G5</accession>
    <name>A0A2Z5R2G5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87089">
        <property type="protein sequence ID" value="BAV87089"/>
        <property type="gene ID" value="RA11412_0790"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0790"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="169" mass="18761" checksum="33210DE0CEB7D331" modified="2018-10-10" version="1">MNKALKMPLYSNKGSFSRTFRMGCMSETILYDPQTRCSCTSGEIYGACCGRYLGEFAASGTLNAPTPLALMRSRFTAFALHDAPYLLASWHPHTRPAELTLDETLRWYRLDILGSSGGPFDAAGTVEFAAYYRSVPGTPAKEHVKGTMQEKSRFEKVNGTWYYLDGEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2H5</accession>
    <name>A0A2Z5R2H5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87099">
        <property type="protein sequence ID" value="BAV87099"/>
        <property type="gene ID" value="RA11412_0800"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0800"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="87" mass="9809" checksum="E7B4FBDF1E815107" modified="2018-10-10" version="1">MMIHVGMLLVSRMALKYPLLEALVDIALILVMICGSGLAFGWFSSTPLWILCILGIVMYGASTALNILHMRREVQEINMLIVRRKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2I9</accession>
    <name>A0A2Z5R2I9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)HX epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_2523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88822">
        <property type="protein sequence ID" value="BAV88822"/>
        <property type="gene ID" value="RA11412_2523"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2523"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="142" mass="14632" checksum="BEB3F01C686E8C9F" modified="2018-10-10" version="1">MGRADAEHPAPSRDDITRQPLRWVKTAAALTGATVMLKGGYSLIASPADTVYSVRGATAWLATAGSGDTLTGILGALLAQKVAAAAQRGTPLEDDVYARVAALAVYLHGRAALASLGGRRGPVPPTRVAQSLPQAIAELLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2K9</accession>
    <name>A0A2Z5R2K9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-proline glycine betaine binding ABC transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88764">
        <property type="protein sequence ID" value="BAV88764"/>
        <property type="gene ID" value="RA11412_2465"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2465"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016269544" evidence="3">
        <location>
            <begin position="21"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="4">
        <location>
            <begin position="48"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="356" mass="37719" checksum="646D07BFC34F79A0" modified="2018-10-10" version="1">MSRRSALTAAALAPILAACSAGDNKPKVDPSASAYGTLYVTTGVLGAKTIVAHAYAQALRNVGYTVEVIGHNNNRDEYLAALGATENTRLDVAVDFTGDLLLHLTKNGTLSPAQLQAEHQTASASASAASAGVTLTPSATPSIPADISPSPSPTPTSDPIKPRALSLSDTLSAIGKIIPGHLKLMDTVSAQNRNVLVTTNATGARYKFNSLNQLPEVKAPLTFAVPEAYNTGNYGIALLKNVYKYQVPATKVANESTEREQLLAKDAVQVALLHSIDPSIEDNRFTMLEDPQSTQLNQQLVPLVRQSLPSSAQEAINRVSSTLDTGNLTFLLRLTSGTNPVAEDEAAKFWLDHPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2N9</accession>
    <name>A0A2Z5R2N9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Probable O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_09750</name>
        <name evidence="1" type="ORF">RA11412_2422</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88721">
        <property type="protein sequence ID" value="BAV88721"/>
        <property type="gene ID" value="RA11412_2422"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2422"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="275" mass="31409" checksum="DDA146A25948EFF3" modified="2018-10-10" version="1">MHPELTDIPETMLWTLHNRAREAARADGCITDPKCLEIYRAIDYDYQAHFGKADGSHGVRSMLFDRQISRFMKEHPDAVIVNLGEGLETQRYRIDSPGTLWVSVDLPAGIDIRERFIAPDERHLHVARNALDTTWFDAVPDGRPVFIAAQGLFMYFTTVEVAALMRSMARRFPGATVMFDYIGRFLSKRTLSEKGWMKTDTYRTPPMPWGVYRNELQPLLSAWLGQQVSVHNVTFELPRGPGKWSVLFIEKYLPQLANKLPGVCWLQLPEADPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2P3</accession>
    <name>A0A2Z5R2P3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88998">
        <property type="protein sequence ID" value="BAV88998"/>
        <property type="gene ID" value="RA11412_2699"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2699"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="80" mass="8687" checksum="84EAF33731C0CA80" modified="2018-10-10" version="1">MAALNLPVTELLPNLEVHVFDDSGGSIFSTLEHGELARQEQFARTVDRFFTVRAAENTDLEAMAAGFGTASGVRVSIHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2T9</accession>
    <name>A0A2Z5R2T9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplE</name>
        <name evidence="9" type="ORF">RA11412_2555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88854">
        <property type="protein sequence ID" value="BAV88854"/>
        <property type="gene ID" value="RA11412_2555"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2555"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="59"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="155" mass="17294" checksum="713A40046F34415C" modified="2018-10-10" version="1">MQIPKVVKVVVNMGVGEAARDAKLMDGAIRDLTAITGQKPIVTRAKKSIAQFKLREGMPIGAHVTLRGDRMWEFLDRLVTLALPRIRDFRGLSDRQFDGNGNYTFGLTEQSMFHEIDQDSIDRVRGMDITVVTSAKTDDEGRAILKALGFPFKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2U7</accession>
    <name>A0A2Z5R2U7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oligo-1,6-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88786">
        <property type="protein sequence ID" value="BAV88786"/>
        <property type="gene ID" value="RA11412_2487"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2487"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="15"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="392" mass="44987" checksum="CDC0AB6407DAA232" modified="2018-10-10" version="1">MKTEIQWWQQPVVYQIYPRSFNDSNGDGIGDLPGITEKIPYLAKLGIDVIWLSPIYASPNDDNGYDISDYRAIMTEFGTMADFDELLATAHEHGIKLMMDLVVNHTSDEHEWFRQARSAKDNPYRDYYVWRDPAGFTEDGTPIPPNNWISCFSPSVWEWDEGTQQFYLHYFSVKQPDLNWENPKVREEVYDIMRFWLDKSVDGFRMDVINLISKDLSFPDDPAVTAGGLDNSLAVAANGPRVHEFLREMNREVLSKYPVMTVGETPCVSVEDAALYTGFDRHELQMVFQFEHMDVDASAGGATGKWSDTRFNLVDLKNVLSHWQTGLHGRGWNSLYWNNHDQPRTVSRFGNDSPEFREVSGKMLGTVLHMMQGTPYIYQGEELGMTNVSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Y9</accession>
    <name>A0A2Z5R2Y9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89063">
        <property type="protein sequence ID" value="BAV89063"/>
        <property type="gene ID" value="RA11412_2764"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2764"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="95" mass="10786" checksum="7404E3CE11C9A85B" modified="2018-10-10" version="1">MSETSNQHSGQDHTGQKTVRVRASELIGRSWLNTGEKNLDLQALRGKIVILDFWTLCCINCLHVLDELRPSKKNSRMCSSLWACTAPNLSMRQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R351</accession>
    <name>A0A2Z5R351_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Maltose/maltodextrin transport ATP-binding protein MalK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_08905</name>
        <name evidence="8" type="ORF">RA11412_2617</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88916">
        <property type="protein sequence ID" value="BAV88916"/>
        <property type="gene ID" value="RA11412_2617"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2617"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="19"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="375" mass="40773" checksum="2B4A835D0B6ED4B5" modified="2018-10-10" version="1">MTTQGSTPQPSSTTTHGGLQIRGVAKSFGADTHVLREIDLEVEPGEMVSLVGASGTGKSTLLRIIAGLEEANAGRITYAGQPLNAGQVGFVFQHPILYPHLSVRKNILFPTTLRGYRQKVDKNYYTDLMDALQIGELQHRKPQELSGGQAQRVGIARALIRKAPVVLFDEPLASVDEELSASIRADIARLHAEYRFTGLYVTHDQNEALQLGQRVAVMDAGYLVQVDTPEHLLANPHTLQAARLTASPALNELTLTEGQHLPAGASLYVRATSLRRIENIAEHPTENTIPVQVRSVLPQVGGTLYRAVTQAEVTVYAASHDGSARVPLQVPSGQPLEFFEPDALALPVLTSGERVQVQVPPHRCFIFADGTRHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R378</accession>
    <name>A0A2Z5R378_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88966">
        <property type="protein sequence ID" value="BAV88966"/>
        <property type="gene ID" value="RA11412_2667"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2667"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="85" mass="9444" checksum="5021102FF7852AF1" modified="2018-10-10" version="1">MGPWTVTQVLQIQVGHPDAVSVGDYHLAHHVGYALRGKRGDDADMLRLLAPYAGHRQRVVRLILAAGATEPRHGPRTPVRDYRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R391</accession>
    <name>A0A2Z5R391_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Copper resistance protein CopC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89074">
        <property type="protein sequence ID" value="BAV89074"/>
        <property type="gene ID" value="RA11412_2775"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2775"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016396398" evidence="3">
        <location>
            <begin position="27"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="4">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV89074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="135" mass="14264" checksum="929CAF22371B756F" modified="2018-10-10" version="1">MRTILRTLLAALTATLLTLTAAPAYAHDELVSSTPAADATLSKAPTEITLTYSANLMNVEGGNRVRVTDSAGNSLVEGKGDAKVSGNTVTQTLNLKDPAADETYTVTWRVVSSDGHPIQGTYRFTVGPVKPPRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3T4</accession>
    <name>A0A2Z5R3T4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87949">
        <property type="protein sequence ID" value="BAV87949"/>
        <property type="gene ID" value="RA11412_1650"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1650"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="5100" checksum="DF3BDF258DE8C5EE" modified="2018-10-10" version="1">MILAYGEGYWHKGHTVDQPQDYYDWEEKYRNDNNLKPYTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R431</accession>
    <name>A0A2Z5R431_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical radical SAM family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88249">
        <property type="protein sequence ID" value="BAV88249"/>
        <property type="gene ID" value="RA11412_1950"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1950"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="77" mass="8582" checksum="D628FF83B4742EC0" modified="2018-10-10" version="1">MIRVREGLPVRELLAVHDPQELGVSLRWLIAQGLIEPKALTANAEPDPQARVRLTLRGRLLGDAVTRELLPEIDHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVE4</accession>
    <name>A0A2Z5QVE4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86352">
        <property type="protein sequence ID" value="BAV86352"/>
        <property type="gene ID" value="RA11412_0053"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0053"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="235" mass="26327" checksum="745D3D33630FBF85" modified="2018-10-10" version="1">MSVTKVPDEELLVFDHEIAANPKRVFTAYLDPSQLHRWYGPAGWRAQTDDLVVESVVGGIQRVRMVNDFDPGATCVLQSRFLAIEPYHELEYAEQLPNHLGEPSDILVYSRFRFHPETVITPEGVGEGTRITVEIGPMPRMFTRRYAPAGVPPSPGWMRCSPNTTTLNKKMPAPNKRMTAPARHRTLASGKPRIASFLALCGAGCRTSPILQVTPVTLELDGIMIIQRRCYENDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVK0</accession>
    <name>A0A2Z5QVK0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86412">
        <property type="protein sequence ID" value="BAV86412"/>
        <property type="gene ID" value="RA11412_0113"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0113"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="57" mass="5822" checksum="50391481D57F2DCD" modified="2018-10-10" version="1">MEEESFNGTATAGHTAGGLGLSKTSLLGQVLNARHVLRCGIRPVWSLIAEAAPGGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVK4</accession>
    <name>A0A2Z5QVK4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease HI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86427">
        <property type="protein sequence ID" value="BAV86427"/>
        <property type="gene ID" value="RA11412_0128"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0128"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="150" mass="16745" checksum="4E50968CB37019A4" modified="2018-10-10" version="1">MAERKEKLAQAAQRAERHEQAAHIQSPQQTQQQLTADPDEALAAEEELEANGAAMGEEEIAELLDENLVWITSAGRPVSRASTIEYRARAFTQRGEPTHRVVELVDTANVLVMAVVDTARGRVNRSSLWHYDAQVGSWRLRFRQDTAIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVL0</accession>
    <name>A0A2Z5QVL0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07680</name>
        <name evidence="2" type="ORF">RA11412_0123</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86422">
        <property type="protein sequence ID" value="BAV86422"/>
        <property type="gene ID" value="RA11412_0123"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0123"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="85" mass="9197" checksum="D6DBC5216FBF56D6" modified="2018-10-10" version="1">MTSERETPLEVANELPYTRAIRWLGVGGGILALLCTLSGVAMLVLKWVDAHPPAVMSQVPLVLFPVAFIALMLALLLAVLRRKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVV2</accession>
    <name>A0A2Z5QVV2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86510">
        <property type="protein sequence ID" value="BAV86510"/>
        <property type="gene ID" value="RA11412_0211"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0211"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016328902" evidence="1">
        <location>
            <begin position="26"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="77"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="250" mass="27846" checksum="5DC3E10B99D822D5" modified="2018-10-10" version="1">MTQSPMTRRTLFALGAPAALVTIAACSKSPSGTSNSTTSKSVSTPDRVVSFNWPEITETKLRDDTGYHLNKLVDGAPTVTLYTDYEVFECIRAELAYEKAAKDLEGTMNVTVRHYPSPNSGYARDSALAVLAAEVQGKHQAMARKLCETHEERYRRGSAVGNLRVKLKGYAKEIGLDVDKFDKTMDDKSIADLLHTDQKHAFLDLRMVRTPEFTVNDKILENIDYNKVLENVESSTPLNIWSKNSRKPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVW4</accession>
    <name>A0A2Z5QVW4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86538">
        <property type="protein sequence ID" value="BAV86538"/>
        <property type="gene ID" value="RA11412_0239"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0239"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="166" mass="18325" checksum="E115364CCB1E2303" modified="2018-10-10" version="1">MGSQVNAGQLETILKYVKIGEQEGCRIITGGKKLEGELGKGEFVEPTLIEADNNNARVAQEEIFGPVATVIKFKTEEEVVKMANDSEYGLGGAVWSKDINRCLRVSNALETGRIWVNCYNRLPAGAPFGGYKTSGIGRETHKMMLAAYTQVKNIYISTREEREGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW05</accession>
    <name>A0A2Z5QW05_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="EMBL" id="BAV86513.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="81" mass="8943" checksum="7AA4B76B27A30B4C" modified="2018-10-10" version="1">MPSSPTGVYSDVHRALSKAGNSAALCAEALAMARCFGECTAHCQRQVTVERRVQTVVEHIQEAERLIARARDERHEPVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW08</accession>
    <name>A0A2Z5QW08_9MICC</name>
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    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="EnsemblBacteria" id="BAV86570">
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    </evidence>
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</entry>
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    <name>A0A2Z5QW20_9MICC</name>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="207" mass="20873" checksum="3662B8145767F62F" modified="2018-10-10" version="1">MHGMLVCVSNKPATSQQHTPQIPAPGSPTRATAQGRGALAVHAVIYLLFGLSTIFIQIPDWGTDRLLIGGLMLALGASHWWVSRGTRYGPATSATLISVALVQAASGALLIAQPDAPAPILLATCGGIGLGALLKGLLGVRYRSVIAAARDWVLEGTVMLAAALAVPFMVNIGPKAVLGVTGGGALIAGVFLLVGALGARTEGTPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
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    <name>A0A2Z5QW28_9MICC</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="39" mass="4516" checksum="59E03F2AFF3E6463" modified="2018-10-10" version="1">MMLMRVFLSLMRLGVLRFCVVQGFNARPGGSIPVQQYLW</sequence>
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    <accession>A0A2Z5QW37</accession>
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    <protein>
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    </reference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86625">
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    <dbReference type="Proteomes" id="UP000250241">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="44" mass="4755" checksum="A9DE3DABA27787A2" modified="2018-10-10" version="1">MSDTGHPFCSALIVTVKPPIRTVHGYSGAAHLYGGNVFYCTERT</sequence>
</entry>
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    <accession>A0A2Z5QWB0</accession>
    <name>A0A2Z5QWB0_9MICC</name>
    <protein>
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        <submittedName>
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    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_06745</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86633">
        <property type="protein sequence ID" value="BAV86633"/>
        <property type="gene ID" value="RA11412_0334"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0334"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007427">
        <property type="entry name" value="DUF475"/>
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    <dbReference type="Pfam" id="PF04332">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="367" mass="39542" checksum="7B67B0D739688568" modified="2018-10-10" version="1">MALLKFFKYDLLITLAALVVAMFYGGVSGMVSAAILIVLEIVFSFDNAGVNAKYLNKMSHAWRRIFLTVGVLVAVFGMRLVFPFLIVCLAGNVGPVEAWNLAMERGDPHTPGTYGYILESAHHTIASFGGMFLLMLFLSFLFEAGKDVHWLAVIERPLAKAGHFDSMPVLVSGAILLAAAQLFGAEHHEQYTILLSGLLGMLTFLATNGLATFMEDRNEAQEESLSEVAMLTGKAAFSMFIFLEVLDASFSFDGVLGAFAVTSDPIIIAIGLGVGALFVRSMTIYLVEKGTLQELRYLDHGAHWAIGVLALMLIATLKWDIPDYVIGLSGIVFIAGSVISSRRANRAEAAENDGDAKEPVASGSSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWD2</accession>
    <name>A0A2Z5QWD2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86701">
        <property type="protein sequence ID" value="BAV86701"/>
        <property type="gene ID" value="RA11412_0402"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0402"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="147" mass="16070" checksum="CE1B98EDB241812A" modified="2018-10-10" version="1">MPHHITLDHISYAHPGEPPLFTDLSTVFSAPLTGLIGDNGTGKTTLFRLILGEIKPSHGTISAPPRIAYLPQDLGLSEHQHLADILELQKFCERSMHWNRATTPPAFMTPSATPGILKSALSRSLPSTVLVLRSPRMPPTRTPFATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWG0</accession>
    <name>A0A2Z5QWG0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA-domain-containing proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86726">
        <property type="protein sequence ID" value="BAV86726"/>
        <property type="gene ID" value="RA11412_0427"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0427"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="89"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="163" mass="17581" checksum="67D0F6F6A69F2B68" modified="2018-10-10" version="1">MASELTVIILRFAFLALLWFFVFLVLAAARRDLGLGKNFRTVSVDAFASPALPAAEQAPVAAPPARPSQLVITEGAQAGAMMQLGDEPITIGRANDIEVSLQDDYASGRHARLFPQGSRWFLEDLGSTNGTYVDGQRLSRATVIEPGTEFRVGGTTMQLRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWJ4</accession>
    <name>A0A2Z5QWJ4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86766">
        <property type="protein sequence ID" value="BAV86766"/>
        <property type="gene ID" value="RA11412_0467"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0467"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="45"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="134" mass="13647" checksum="36CFABE709E8E642" modified="2018-10-10" version="1">MSTNTTTGGLFGNAALGGVRLGAASTKPEGASTSAAEQGEQTVHNVIIVGAGPAGYTAAIYAARANLSPVLFASSVSPGGALMNTTEVENFPGFIEGIQGPELMTNIGAQAERFGTDIRYQDVEKLDLTGEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWP8</accession>
    <name>A0A2Z5QWP8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">RA11412_0556</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86855">
        <property type="protein sequence ID" value="BAV86855"/>
        <property type="gene ID" value="RA11412_0556"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0556"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV86855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="125" mass="12722" checksum="6F175967A00514F8" modified="2018-10-10" version="1">MSAAAVCVGGGLGAVLRYYLERFLAPRRTSDALISAVFVINVLGSLALGIVGAAVNVLGGQDAVAYAGLSLGLLGGFTTFSTAMVEAVQALLAGRYARFVMLWLVQPMLSLIALIAGYTAAAAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX15</accession>
    <name>A0A2Z5QX15_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="9" type="ORF">I6I94_05745</name>
        <name evidence="8" type="ORF">RA11412_0584</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888463.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86883">
        <property type="protein sequence ID" value="BAV86883"/>
        <property type="gene ID" value="RA11412_0584"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0584"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="187"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="310"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="378" mass="41095" checksum="E4EEB5D10D45A63C" modified="2018-10-10" version="1">MLILVVNAGSSSLKYQVRDTSAPEAEQMLTSGLIENIGTDVPDHEVALHMMADKLKDVLHGRELQAIGHRVVQGAEKFTHPVLLNEQVIDEIDALSPLAPLHNPAHVKGMRAAFHTWPDLPQVAVFDTAFHSTMPEHAWRYAIPYDLADKYSIRRYGFHGTSHEYVSHVAADMLGIARDEFNGVVAHLGNGASVTAVKGGKSVDTSMGYTPLAGLVMGTRSGDIDPSALTTILTRDPEIDAERLDTILNKESGLLALAGSNDMRKVVESAQSGDERAQLALDMTAYRLMKYIGGYNLVVGGAQALIFTAGIGENSGDFRKLVLDRLAPLGIRYNEEENMKRSPEPRLISTEDSSIAVFVIPTNEEKAIAEATEELVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX79</accession>
    <name>A0A2Z5QX79_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87032">
        <property type="protein sequence ID" value="BAV87032"/>
        <property type="gene ID" value="RA11412_0733"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0733"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="186" mass="21160" checksum="A0CBC76B42765F36" modified="2018-10-10" version="1">MGVPVVALVPDAFTEMRLTGVMKHYGVGEFITPLEMLGTAIPSLLLDAAVQLNDPELGATFTELQAPRRAEVLGALAEWRQYVWERISGNDEAREPQNLPKVHQVEALNEPLRGVNRAARRLLRRTSLEAGNEWALSDRMHSWEDARRREIEEKDREIAGLRERAEAAERKLAEYQGSLLKRILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX90</accession>
    <name>A0A2Z5QX90_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ppa</name>
        <name evidence="7" type="ORF">I6I94_05280</name>
        <name evidence="6" type="ORF">RA11412_0692</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86991">
        <property type="protein sequence ID" value="BAV86991"/>
        <property type="gene ID" value="RA11412_0692"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0692"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV86991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT90001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="161" mass="18193" checksum="67B07399D3776137" modified="2018-10-10" version="1">MELDVTIEIPSGSRVKYEIDHETGRLRLDRVLFTSMQYPTAYGYFENTLGEDGDPLDAMVMIDVDVLPGVIVEARPVAVFNMTDEAGGDAKVLCVPSDKRYDHIKTLADVPEQLKAEIQHFFERYKDLEPGKWVKGEGWDDLPAAEKMVQEAIDRFAAECH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXD8</accession>
    <name>A0A2Z5QXD8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86894">
        <property type="protein sequence ID" value="BAV86894"/>
        <property type="gene ID" value="RA11412_0595"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0595"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029455">
        <property type="entry name" value="GHL15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14885">
        <property type="entry name" value="GHL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="147" mass="16427" checksum="527AC5F06EA8220B" modified="2018-10-10" version="1">MINNTALRAGVPGRFGAWIRYGGDPITRKQLEFAVQNYSVAILQPWEQDAALYLKKNAPDMVVLAYKCLSSTRSYEPGPIYSSGVSWDTAQQALQNGKDLYARRTDGSLIEWRGYPSTTRWRYGTPTTAGTGWTRSSKNCVTRHLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXE5</accession>
    <name>A0A2Z5QXE5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ketopantoate reductase PanG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87013">
        <property type="protein sequence ID" value="BAV87013"/>
        <property type="gene ID" value="RA11412_0714"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0714"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018931">
        <property type="entry name" value="DUF2520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019665">
        <property type="entry name" value="OxRdtase/DH_put_Rossmann_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037108">
        <property type="entry name" value="TM1727-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10728">
        <property type="entry name" value="DUF2520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10727">
        <property type="entry name" value="Rossmann-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rossmann-like" evidence="2">
        <location>
            <begin position="12"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2520" evidence="3">
        <location>
            <begin position="151"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="325" mass="33989" checksum="ECAD9DA1E9304A73" modified="2018-10-10" version="1">MNILDSVTMNHLKPARLGIGIVSAGKVGAVLGAALRSAGHAIVGVRAESDASAERAENLLPGIPVLPTEQIIERSELVLLAVPDDALQPVIEGIATGGMVSPGQLFVHTSGRHGAGVFKPLTEQGTIGLAVHPAMTFTGLSLDVQRLNGASFAVTGPAPFIPIAQALVVEMGGEPVHIAEADRALYHAALAHAANHLVTIMGQSQQALASIGVEDPSHYLGPLVRAALDNALAAGETALTGPVIRGDSGTVTEHLRALREYAEQENTRDIADSYAELVKSTAKRAHNRGLLNDEQLGRVESTLTEHTSFMDTTDPAPQTRSSRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXF6</accession>
    <name>A0A2Z5QXF6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ftsH</name>
        <name evidence="12" type="ORF">RA11412_0701</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87000">
        <property type="protein sequence ID" value="BAV87000"/>
        <property type="gene ID" value="RA11412_0701"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0701"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="12" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="212"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <name evidence="2" type="ORF">RA11412_1046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87345">
        <property type="protein sequence ID" value="BAV87345"/>
        <property type="gene ID" value="RA11412_1046"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1046"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010539">
        <property type="entry name" value="UCP009160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41282">
        <property type="entry name" value="PTHR41282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12811">
        <property type="entry name" value="BaxI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="164" mass="17434" checksum="45B3974998AF30B1" modified="2018-10-10" version="1">MVLAYALAEGLLLGGLSGLLNARYPGIALQAVIATVVVFGTLLALFANGKIRATPKLTKIFLGASLGYLAFFVVSWGVSLFTHTSLMNTSVAGLPLGLIVGVFGVALASYSLVLDFTNTTEAVEAGLPERESWRLAFGLTASLVWLYIEILRILMYLASIFSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY37</accession>
    <name>A0A2Z5QY37_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycothiol S-conjugate amidase Mca</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87352">
        <property type="protein sequence ID" value="BAV87352"/>
        <property type="gene ID" value="RA11412_1053"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1053"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010126">
        <property type="term" value="P:mycothiol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017811">
        <property type="entry name" value="Mca"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF16">
        <property type="entry name" value="PTHR12993:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="199" mass="21718" checksum="720F010FCB81B895" modified="2018-10-10" version="1">MSDAVARLKAQLPEHPSVDELTPLADDYTGLRILAVHAHPDDESSKGSASAAAYTDRGARYMVATMTGGERGDILNEEIKHSPRDHRDLPGMRRSEMAAAAKAIGIEHRWMGFVDSGLPEGDPMPPLPFGCFGVQPLERAAAPLVRLVREYRPHVMISYDEIGGYPHPDHIMSHKVAVEAYEKAGDPEAYVGRGSRGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY61</accession>
    <name>A0A2Z5QY61_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_0984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87283">
        <property type="protein sequence ID" value="BAV87283"/>
        <property type="gene ID" value="RA11412_0984"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0984"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="232" mass="24570" checksum="908B94DF7257D82F" modified="2018-10-10" version="1">MSTSQTNTQHPNHAKPSFGLSPATIVTLAALTAIAPLGIDMYIASLPTIAEELHTTEAAASMTLSAFMVGMALGQLIIGPLSDKTGRRSPLLIGSAVCFAATALCAFSPTIEVFIAARFLMGFSGSVGAVLARSIVADTTKGLATAKLMGIMMMINGFAPVLAPLFGGWVLSWGTWRSVFNVLTVITGALMLAVIFILRETLPAEKRYQGTALSVYSEIPKVFRIRRYMGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYB1</accession>
    <name>A0A2Z5QYB1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminodeoxychorismate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87281">
        <property type="protein sequence ID" value="BAV87281"/>
        <property type="gene ID" value="RA11412_0982"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0982"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="295" mass="32204" checksum="5777AEE003B8D5E9" modified="2018-10-10" version="1">MILLNSENPQGVAVDPAQPLIGVEDQGFTRGDGVFETMLAVNRRVRKLDMHLTRFESSARMLDLPKPDLHQLREALASLLDQAVPGAHTEIGEEHIVKIIISRGLPHASAGMPAGPYTLLIASPVPETTVNQRQNGVKAMLLPRGHDPADNTAYPWLLAGAKTLSYAVNMAVLRYVHSHGADDAIFMTDNRRILEGATSSVLMARIEHGKKMLYTPEPNHGILPGTTQGAIFEAARRDGWELGYGPLYPQDLFESDGVWLSSSVRLLAPVTRLNGTALAHDAQLTHQFLEYLAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYE4</accession>
    <name>A0A2Z5QYE4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fructose-1,6-bisphosphatase class 2</fullName>
            <ecNumber evidence="4">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-fructose-1,6-bisphosphate 1-phosphohydrolase class 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_1067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FBPase class 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87366">
        <property type="protein sequence ID" value="BAV87366"/>
        <property type="gene ID" value="RA11412_1067"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1067"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="252" mass="26439" checksum="48ED0413986368BC" modified="2018-10-10" version="1">MDAMRYRLSSVNFNGTVVIGEGEKDKAPMLFNGEVVGDGTGPNLDIAVDPIDGTRLTALGMNNALSVIAVADGGSMFDPSAVFYMEKLVTGPEAADFVDLRLPVKQNLHLVAKAKGKKINELTVCVLDRPRHAKLIEEIRACGARTRIILDGDVAGAIAACREGTGVDVMLGTGGTPKVLLLPALLKPPGALSRAAWHPPMTPSVRRRSPLGTTLTGSSPLMIWSPAITVSSPQPVLPTASCCAVYGTARTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYE8</accession>
    <name>A0A2Z5QYE8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="2">HAT</shortName>
            <ecNumber evidence="2">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Homoserine transacetylase</fullName>
            <shortName evidence="2">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">metXA</name>
        <name evidence="7" type="ORF">I6I94_03290</name>
        <name evidence="6" type="ORF">RA11412_1198</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87497">
        <property type="protein sequence ID" value="BAV87497"/>
        <property type="gene ID" value="RA11412_1198"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1198"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="47"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2 3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="410" mass="43474" checksum="539609221DE86F77" modified="2018-10-10" version="1">MTGTPETAQGILRHHSIGDLRLENGITLPEVRISYETWGTLNEDGDNAILILHALTGDTHVSRGSAPEGTPADVAAEIERDGWWEGIVGPGAVVDTNKYYVVAPNILGGCYGSTGPASLIPAGYPGEGQPWGGAFPQVSIRDSVHAEARLAQTLGITSFRYVIGGSLGGARALEWAATYPHLVRGCAVIASGPAATAEQIAWAHTQNVAIRSDANFASGDYYDGPAPTAGLALARRIAHTTYRSPAELEHRFGRSENPHETVTGGTLGAPRGRYAVESYLDHHGDKLIERFDANSYLAVNEALISHDAARGRGCLTHALAFSNCEWTIAAVDSDRLFFPHEAQLLADSLPVPAEVQIIESEHGHDGFLIEAAQVERILAHALGEKPQSTPPNLSTIGDKEPLPAASSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYJ1</accession>
    <name>A0A2Z5QYJ1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="7">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmI</name>
        <name evidence="10" type="ORF">RA11412_1081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87380">
        <property type="protein sequence ID" value="BAV87380"/>
        <property type="gene ID" value="RA11412_1081"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1081"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018063">
        <property type="entry name" value="SAM_MeTrfase_RsmI_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01296">
        <property type="entry name" value="RSMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="9">
        <location>
            <begin position="30"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="305" mass="31882" checksum="EEAB34DDB177BED3" modified="2018-10-10" version="1">MPEAETPDQAPAEHTGPHAAAHGTGGGVLILGGTPIGNLSDASDRLRQALATADVIAVEDTRKLRTLASGLGVRTTGRVIVNHDHNEEYRSTQLVQAVSDGNTVLLLSDAGMPTISDPGYVAACAVADAGLPVTVIPGPSAALTALALSGLPTGRFTFEGFLARKGSERTRRLNSLAAEERTMIFYESPHRVAATLTDFARVFGGERRAVVCRELTKLHEETLRGTLNELAGWARATQVRGEIVIVVAGAEPAETPQAQDIVGLVLERVDAGERLKNACAAVAAETGASKQELYAAAIAARNVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYJ2</accession>
    <name>A0A2Z5QYJ2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-deoxy-D-xylulose-5-phosphate reductoisomerase</fullName>
            <ecNumber evidence="3">1.1.1.267</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_1223</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87522">
        <property type="protein sequence ID" value="BAV87522"/>
        <property type="gene ID" value="RA11412_1223"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1223"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="7"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="170"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="276" mass="29076" checksum="193D581A78841621" modified="2018-10-10" version="1">MRTPSRVTLLGSTGSIGTQAIQVIEHLARLAGTTVDAEDAPLKVAALSAGSRSLELLAQQAVLVRAELVATSGTAQDAQRLREYLDAAARSTGISGYSPRIVWGERASVEAAAHPADVVLNGITGSIGLEPTLTALKAGYRVALANKESLIAGGPLVRAAVDASPLETPMVPVDSEHSALAQALTSGTDAEIDRLILTASGGPFRGYTREMLHDVTPRQALAHPTWDMGLVVTTNSATMVNKALEVLEAHHLLGLILTALMLRYTRSRLCIQWFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYK0</accession>
    <name>A0A2Z5QYK0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">S-ribosylhomocysteine lyase</fullName>
            <ecNumber evidence="4 14">4.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">AI-2 synthesis protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 14">Autoinducer-2 production protein LuxS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">luxS</name>
        <name evidence="15" type="ORF">RA11412_1246</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:17753"/>
            <dbReference type="ChEBI" id="CHEBI:29484"/>
            <dbReference type="ChEBI" id="CHEBI:58195"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.4.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="14">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the LuxS family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.21" evidence="4 14"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87545">
        <property type="protein sequence ID" value="BAV87545"/>
        <property type="gene ID" value="RA11412_1246"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1246"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043768">
        <property type="term" value="F:S-ribosylhomocysteine lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00091">
        <property type="entry name" value="LuxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037005">
        <property type="entry name" value="LuxS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003815">
        <property type="entry name" value="S-ribosylhomocysteinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35799">
        <property type="entry name" value="PTHR35799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02664">
        <property type="entry name" value="LuxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006160">
        <property type="entry name" value="AI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01487">
        <property type="entry name" value="LUXSPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0071">Autoinducer synthesis</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0673">Quorum sensing</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAV87545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="152" mass="16910" checksum="DC0DDB60277DEE0F" modified="2018-10-10" version="1">MEKMNVESFNLDHRAVAAPYVRIADRKMLPGGDTLIKYDVRFTQPNTAHLDMPAVHSIEHLSAELMRNHTDKLIDFSPMGCQTGFYALTLGIEPQEFMPILEATMRDILEATEVPAANEVQCGWGAHHSLGAAQEAARGFLAARSEWEQVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYQ9</accession>
    <name>A0A2Z5QYQ9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Capsular polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87421">
        <property type="protein sequence ID" value="BAV87421"/>
        <property type="gene ID" value="RA11412_1122"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1122"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="202" mass="22376" checksum="322487851D0B92D0" modified="2018-10-10" version="1">MIFLRRSVDQRIRTRDDAVKATGSSILGVLPTSDDLTEENIVTGSSNDHIAQESIRQLRTNLRFVNIDEPPRSFLVTSAVPSEGKSTVSLSLARSMAESGQAVILIDADLRRPTLAKKLNVDAKVGLTQVLAGQVDIAEAVYQLEESNLFVLTAGRIPRTPQNCWAPIRCASWSGNYPKSSWWFWMPHRCCPSPMPHCSPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYT2</accession>
    <name>A0A2Z5QYT2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsB</name>
        <name evidence="8" type="ORF">I6I94_03210</name>
        <name evidence="9" type="ORF">NCTC10207_00634</name>
        <name evidence="7" type="ORF">RA11412_1217</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006889032.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87516">
        <property type="protein sequence ID" value="BAV87516"/>
        <property type="gene ID" value="RA11412_1217"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1217"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VEI22553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="268" mass="30155" checksum="ED020F8967B718CF" modified="2018-10-10" version="1">MPVVTMREMLDSGVHFGHQTRRWNPKMKRFILTERNGIYIIDLQQSLEFIDKAFEAVKATVAHGGNILFVGTKKQAQEAIAEQATRVNMPYVNHRWLGGMLTNFSTIAKSIERMKELEQIDFDDVAGSRYTKKELLLMRREFEKLEKTLGGIRNLTKVPSLVWVVDTKKEHLAVNEAQKLGIPVVAILDTNCDPDEVAFPIPGNDDAIRSVNLLTRVVADAVAAGLLERNAKKSGKAETTEEPMAAWERELLEQHEAAKTEESAEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ19</accession>
    <name>A0A2Z5QZ19_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Deferrochelatase</fullName>
            <ecNumber evidence="6">1.11.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peroxidase EfeB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">efeB</name>
        <name evidence="9" type="ORF">I6I94_02840</name>
        <name evidence="8" type="ORF">RA11412_1307</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22585"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="6">Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87606">
        <property type="protein sequence ID" value="BAV87606"/>
        <property type="gene ID" value="RA11412_1307"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1307"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033212">
        <property type="term" value="P:iron import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006313">
        <property type="entry name" value="EfeB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01412">
        <property type="entry name" value="tat_substr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="438" mass="48093" checksum="1964013DF7F72752" modified="2018-10-10" version="1">MREENYPVPPTDQDTTPHGTNRRALLTGTALTAVGIAAAGTLASCATEQKQNDSKDNKSQEVKDTHSFFGEHQSGISTEVQDRMYFVALTLKTTDKEEIKKLFKDWTAASQKLMAGEVVGDVSTYEAPPKDTGEAYDLSAAHLTLTFGLGRSFFVDKDNKDRFGFKDKLPAALVNIPKMSGDALDDKRSGGDLCIQACADDPQVAFHAIRNLIRIAAGRAVVHWSQLGFGRTASTSTSQVTARNLFGFKDGTNNLKIQEPELLKKHVWASSENSEGNPDWMNGGTYLAARRIRMIIETWDRSRLHEQEDIIGRTKVSGAPLSGGEEFTTPDFNMKGKNGPIIPDDSHMRLMHPNQNNGVQMLRRGFNYTDGSDGLGHLDAGLFFIAFVCDPRTHFIPLLDTMTQSDALSEYLKHTGSAVFAVPPGIKDENDFIASGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ55</accession>
    <name>A0A2Z5QZ55_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulatory protein RecX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87570">
        <property type="protein sequence ID" value="BAV87570"/>
        <property type="gene ID" value="RA11412_1271"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1271"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="57" mass="6818" checksum="85DCF53CEB0FB0E4" modified="2018-10-10" version="1">MRKKLRPAMNFSDRTEKEKIMRRLVGMLARRGYSSSVAFSVVKEEIERYCSEWEEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ62</accession>
    <name>A0A2Z5QZ62_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87727">
        <property type="protein sequence ID" value="BAV87727"/>
        <property type="gene ID" value="RA11412_1428"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1428"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="304" mass="34082" checksum="FE7ACAC09514AF6A" modified="2018-10-10" version="1">MKISGLFIAVSAVISVINIAVWSLISSGFNVNTSFYLLSKGVGGAFNFQSIAIFPALTTIFILLNVYLFNKSVDGNRGLKANLLFLWFASGVFNILLVAGIFLKTPNLFKEGILDLETSWGRILLAFGLLAIPFSSAYVMYALFFGDLESEDKTYQSDKPIDLSKIICYSGSIVIILSFMWPVHLYYKGYGSECFEVSNNSVSDRVLRNIPENNLTDDQKNKIRESLKESWSVLGEEGEKFSIFVTREDKDTIDGVLFKRFAETKDEEGQVVKKWLEERSSGKIITINRKAIKSRNPQVCSSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ77</accession>
    <name>A0A2Z5QZ77_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type multidrug transport system ATP-binding component yhiH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87748">
        <property type="protein sequence ID" value="BAV87748"/>
        <property type="gene ID" value="RA11412_1449"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1449"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="239" mass="25267" checksum="88C7EA21ECB484E8" modified="2018-10-10" version="1">MRILLGLETATAGEATLFGQSPSLGSRRRIGYVAQGLGLYPSLSALENLEFAASVQGVAVSKQARSFAERYGHAPVTTLPLGAKRTLAYLAAIGHNPKLLVLDEPTSGMDALTRARLWENLRALADNGTGILVTTHYMQEAAQCDRLVMLAAGKVTGTGTVDEITAGHSSLVVSAKRWEEAFKLLQDAGIPALLDGRTLRLPGAGRGPVTTALQPLGEQVHLQEGTATLEETMLLDAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ99</accession>
    <name>A0A2Z5QZ99_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">atpB</name>
        <name evidence="14" type="ORF">I6I94_02190</name>
        <name evidence="13" type="ORF">RA11412_1469</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888864.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87768">
        <property type="protein sequence ID" value="BAV87768"/>
        <property type="gene ID" value="RA11412_1469"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1469"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="PTHR11410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV87768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT90055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="263" mass="28562" checksum="25AF3727EEF77642" modified="2018-10-10" version="1">MIENGSVLAEGYVPPTPDEMHLPDLFAIGSFGVGKQMLLVLLSVVIIAGFFLWAGRKRAMVPSRTQFVAESGYLFARNSLAKELIGAHHFKPFIPLLFASFYFVLVNNLYGSIPLLQLPSFSHPGSAYALAAIAYLSWVGVGIKRKGLGGFFKDLTMPSGVPVWVYPILIPIELLSNMVIRPVTHSLRLFATMFGGHMAMMVAASLAQYMIDSMGGVGYAAAIAPGALGMFLYFLELMIQVIQAYVFALLLAVYMQGSVSEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZA1</accession>
    <name>A0A2Z5QZA1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87610">
        <property type="protein sequence ID" value="BAV87610"/>
        <property type="gene ID" value="RA11412_1311"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1311"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="49" mass="5275" checksum="6060C9CC1C4A2AC5" modified="2018-10-10" version="1">MGATDNALHTGFFDTFTGESLLLPSGTTRTWHQFTVLPLECVSGSIEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZJ9</accession>
    <name>A0A2Z5QZJ9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain-containing protein EC-YbbN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_02120</name>
        <name evidence="3" type="ORF">RA11412_1487</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87786">
        <property type="protein sequence ID" value="BAV87786"/>
        <property type="gene ID" value="RA11412_1487"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1487"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="65"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="328" mass="34448" checksum="5B68FDFD271E34C3" modified="2018-10-10" version="1">MSENSHELQWGNPAAAGKQPEAAQIPASVRNVPDLGSLAASAGVPPQPGNTDPHAAAQGTPTWRVEVNTPEDFQKYVQESSRGAVIFALYAEHSPSSVQMVDAVQKLVDSAAGSLLLAAVDIAKLPEAAQAFGVSGVPAGVAVLAGRPAPIYNGTVGEQELADVLGQLIQLAAQYQLPGGFEPIYAEEEKPVPPLHAKAVEALDAGDYEGARAAYKQAISDNPGDKEAKLGLEQVELLVRVKNLDMAAERAAAAADPLNIEAAFNVADLDVVGGHVEDAYARLLRLFKAVPADEKTRVRERLVQLFDVVGTADARTVKARAELTVALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZM8</accession>
    <name>A0A2Z5QZM8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87816">
        <property type="protein sequence ID" value="BAV87816"/>
        <property type="gene ID" value="RA11412_1517"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1517"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="318" mass="33281" checksum="C0B14F63F3C89326" modified="2018-10-10" version="1">MCLAVGVTIPPWSVLSQRHRAHNTEFAGNGPVVMAWSNMLNLSMYPLAALLTLPAMYYGGGRAGLWVTAALDVLLIAAVLFTPSLLPGSWPRAAVTAAPTPSAASALLQHPETQLPHTGRGVHVNVLKLLLVLGTAMLGACLGSAATGLLGMVMSYDSLYLYPVMIAVGTGVIVVVAVPILLGGFRIVPWQGWLVSGVTLVFAAMLLPASSSIEGTTGALVLFGAALGASLAGQSLSLSMLMGHSPDSQVSFIARSMSAVGITMGSMWGGFLGDSPYYRNAFMVPIIAACLYLALGHVFGYVWRLDYEEHLEPLPEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZR8</accession>
    <name>A0A2Z5QZR8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87863">
        <property type="protein sequence ID" value="BAV87863"/>
        <property type="gene ID" value="RA11412_1564"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1564"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="156" mass="17481" checksum="774A300CC7AB492D" modified="2018-10-10" version="1">MDFDDGFALEDVTEPSLDLDYPVIHTLTAEDGYTPRKWQVAAPEEQVTISIRQISDEFTDLDKVLAPLDNGHGCAAVICNTVGRAQEAYEHLRAKFGNDVMLAHSRFTAKHRAEKEAALVSLLGKDSHRGDGRPERLIVVEHRSLNSPWILILMSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZR9</accession>
    <name>A0A2Z5QZR9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87995">
        <property type="protein sequence ID" value="BAV87995"/>
        <property type="gene ID" value="RA11412_1696"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1696"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="271" mass="30020" checksum="C56F4114B50BC840" modified="2018-10-10" version="1">MMPEQFAGVSMMVWLACVYALGLVAVGWGFDILAKRTSQRFVASRTFGFTYHESNDAWLCPEDQWLWPVAFDTDNRVMRYRAKPSVCNTCPIKDTCTVSSNGRELTREVDEWPYSESGKFHRGLAVAVALFGPVIMVAAAFGWHSPIELLIELAAVVVCLSLTYPLAIKLIRSPENFAADPKHIPGSSADESVATKIDRFAAKWGGVGNERKRRTDDARKQMIASAQLPVRPSSTIDPDRPAWSGEGTSTPRLHKTTAEVIQEQNLEEANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZT2</accession>
    <name>A0A2Z5QZT2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name evidence="3" type="ORF">I6I94_01355</name>
        <name evidence="2" type="ORF">RA11412_1669</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87968">
        <property type="protein sequence ID" value="BAV87968"/>
        <property type="gene ID" value="RA11412_1669"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1669"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="205" mass="22299" checksum="D677EA9EC520574D" modified="2018-10-10" version="1">MTEKTLRRYAITGGIGSGKSTVAAMFAHLGAVIIDADAISRDLMRPTENTLNAVVAEFGPDILHPDGTLNRPALAALVFSDEDARTRLNNIVHPAVRARADALVEQAWRAPGFSGIIIDDIPLLAETNRAAEFDGVIVVRTSLEKRLTRLMETRGMAEEDARARIAAQATDTQRAAIATWIIDNDGSAENTQTQVERIWALMTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZU3</accession>
    <name>A0A2Z5QZU3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">30S ribosomal protein S1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">SSU ribosomal protein S1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsA</name>
        <name evidence="5" type="ORF">I6I94_01360</name>
        <name evidence="4" type="ORF">RA11412_1668</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887293.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87967">
        <property type="protein sequence ID" value="BAV87967"/>
        <property type="gene ID" value="RA11412_1668"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1668"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="3">
        <location>
            <begin position="33"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="3">
        <location>
            <begin position="120"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="3">
        <location>
            <begin position="206"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="3">
        <location>
            <begin position="291"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="484" mass="53338" checksum="96C7C45C707A32C6" modified="2018-10-10" version="1">MSTNIPQVAINDIGNEEEFLKAVDETIKYFNDGDLVSGQVVKVDHDEVLLDIGYKTEGVIPSRELSIKHDVDPGEVVTVGDEIEALVLTKEDKEGRLILSKKRAQYERAWGDIEKIKENDGVVTGTVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLAPYIGQQLEAKIIELDKNRNNVVLSRRAWLEQTQSEVRSTFLNQLEKGQVRDGVVSSIVNFGAFVDLGGVDGLVHVSELSWKHIDHPSEVVEVGQKVTVEVLEVDLDRERVSLSLKATQEDPWQAFARTHALGQIVPGKVTKLVPFGAFVRVEDGIEGLVHISELAVRHVDLADQVVSVGEELFVKIIDIDMDRRRISLSLKQANEGIDPNATEFDPALYGMAAEYDENGEYKYPEGFDPEKGEWLEGYEAQREAWEAQYAEAQARFEAHKVQVAKALEADAEAAASAPVAAEPAPTSYSSDDKSSAGTLASDEALAELRKKLTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZV7</accession>
    <name>A0A2Z5QZV7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88035">
        <property type="protein sequence ID" value="BAV88035"/>
        <property type="gene ID" value="RA11412_1736"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1736"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="69" mass="7628" checksum="9F295376561C302F" modified="2018-10-10" version="1">MPQPITLTERRARLKTMLKSTGPINMEAYREAIRGATEEERASLARTVQPAKILGSEREAAQAPKPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZY4</accession>
    <name>A0A2Z5QZY4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit beta</fullName>
            <ecNumber evidence="11">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">atpD</name>
        <name evidence="14" type="ORF">I6I94_02160</name>
        <name evidence="13" type="ORF">RA11412_1475</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="11"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87774">
        <property type="protein sequence ID" value="BAV87774"/>
        <property type="gene ID" value="RA11412_1475"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1475"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="161"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV87774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT89455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="487" mass="52883" checksum="D23518DA53A6F296" modified="2018-10-10" version="1">MTATYNESVSAPTQGATGRIARVIGPVVDVEFPAGQVPDIYNALTTELTLDGRTRTITFETAQHLGDSLVRAISLQQTDGLVRGQAVIDTGAPISVPVGDGVKGHLFNVLGDALDVPNSEITADAYWPIHRAAPGFAELEGSTEMLETGIKSIDLLTPYIKGGKIGLFGGAGVGKTVLIQEMITRVARNFGGTSVFTGVGERTREGNDLWVEMEEAGVLKDTALVFGQMDEPPGTRLRVALTGLTMAEYFRDVKNQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPNLADEMGLLQERITSTRGHSITSMQAIYVPADDYTDPAPATTFAHLDATTELSREIASRGLYPAIDPLTSTSRILDPQYIGQEHYDTAIRVKAILQENKELQDIIAILGVDELSEEQKVVVARARRIEQFLSQNTYTAKQFTGVEGSTVPLKDTIESFQMICNGDVDHIPEQAFYNIGGMDDVMRQYEEIKAQTGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R010</accession>
    <name>A0A2Z5R010_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA recombination repair protein RecO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88095">
        <property type="protein sequence ID" value="BAV88095"/>
        <property type="gene ID" value="RA11412_1796"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1796"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="150" mass="16333" checksum="DC260F854C0B022E" modified="2018-10-10" version="1">MSTPKTYTDHALILRTQNLGEADRIIIMLTRNNGITHAVAKSIRKPNSKFGARLEPYMHVALSLTQGRGTLRTITQTTTLHAYTAPIMGDYTAYTTAAVIAETCETLTTNTPPEETPPHYTLTHGALATLAHKNTTRTTSSHATSPKPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R049</accession>
    <name>A0A2Z5R049_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mg(2+) chelatase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">YifB family Mg chelatase-like AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_01680</name>
        <name evidence="4" type="ORF">RA11412_1617</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87916">
        <property type="protein sequence ID" value="BAV87916"/>
        <property type="gene ID" value="RA11412_1617"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1617"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="216"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT90049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="513" mass="54324" checksum="3656B0E64910A1B8" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R055</accession>
    <name>A0A2Z5R055_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bacterial proteasome-activating AAA-ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_1846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88145">
        <property type="protein sequence ID" value="BAV88145"/>
        <property type="gene ID" value="RA11412_1846"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1846"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041626">
        <property type="entry name" value="Prot_ATP_ID_OB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17758">
        <property type="entry name" value="Prot_ATP_OB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prot_ATP_OB_N" evidence="5">
        <location>
            <begin position="133"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Prot_ATP_ID_OB" evidence="4">
        <location>
            <begin position="185"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase_AAA_core" evidence="3">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="412" mass="44393" checksum="EE71B1F666CB6EE1" modified="2018-10-10" version="1">MSGSEPAQHTETQGQQPSPAPHYSASYAQTPGATPGPMPSARAVSPQEYDALLRRLSAAESTRTNMERNIRSAGEKNRKLVEALTRAKAEIERLRVSLAQQVMPPLNSALILAVGTGRTTYTQLADGKTPAETEDYLDVQAGGRLVRVPISPLLERSDLAPGMTVLLNEQSEAVLSLGYEGYGDVVTVREVLTDAKVLIDTASGAQQVARIGGALASETLRTGDAVTLDTRTRMITAKVPASRSQELVLEEIPDISYAQIGGLTTQLEQIRDAVELPYLHPEIFERYHLAPPKGILLYGPPGNGKTMIAKAVAHALAERAAALNPGLILAGTSSILKALNFSISSWAKPNGRSGIFLLRPAKKRRQGTPWWCSSTRWSPFSVRAAPAAPPILRPQSCRSCLPKLMVWNHSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R074</accession>
    <name>A0A2Z5R074_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="9" type="ORF">RA11412_1833</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88132">
        <property type="protein sequence ID" value="BAV88132"/>
        <property type="gene ID" value="RA11412_1833"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1833"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="81" mass="8864" checksum="7C63C9B11D87DA1B" modified="2018-10-10" version="1">MGQIFSHPATIIVVILLIVLLFGAPKLPGMARSLGQSMRIFKSEVEGMKSDGKEAKKMVKERKTKPSPPRLWTTVSPTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0F2</accession>
    <name>A0A2Z5R0F2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86329">
        <property type="protein sequence ID" value="BAV86329"/>
        <property type="gene ID" value="RA11412_0030"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0030"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="2">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="130" mass="13916" checksum="9313A06AF5B9DE04" modified="2018-10-10" version="1">MDAFAEGATARGANVQKIGLISTDVLYFACGVENAAGVTFTASHNPAEYNGMKMAKAGAVPVSSETGLFDIRDLAQKYLDEGSIPTVENPGAVTEKDVLKAYAEYLRQLVDLSSIRPSKLLWMRVTAWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Q2</accession>
    <name>A0A2Z5R0Q2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4253 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_01035</name>
        <name evidence="2" type="ORF">RA11412_1767</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88066">
        <property type="protein sequence ID" value="BAV88066"/>
        <property type="gene ID" value="RA11412_1767"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1767"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025349">
        <property type="entry name" value="DUF4253"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14062">
        <property type="entry name" value="DUF4253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4253" evidence="1">
        <location>
            <begin position="173"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="280" mass="32368" checksum="2AD5D0C76DAA3D80" modified="2018-10-10" version="1">MPEQTPTEVYEQYTRIFPYPHERITEGTSAEQIMGRYYTLLAQGKEQGYVPVFVRTTDTLLEDILFKLADEHNLPDELDLITPDHARAYTHNMLEKYRASLKDLSVEERGKKEIAENLDLFLEDEEAFFRNMVETFKEPSFLPDGIEHTEQPVFVTINSFEGGDNITEGELLLVQVPADNPADIPAYLPFGGWNDCPDTESQLAFTHYWYQKYGAIPGLLDGHDTLEFYVERPVTDPNETKQLAVEQFAFCSDAPTQVFDSFETLATAIHHSKQWYFWWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0R7</accession>
    <name>A0A2Z5R0R7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LssY_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88337">
        <property type="protein sequence ID" value="BAV88337"/>
        <property type="gene ID" value="RA11412_2038"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2038"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025902">
        <property type="entry name" value="LssY-like-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14067">
        <property type="entry name" value="LssY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="LssY_C" evidence="2">
        <location>
            <begin position="102"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="439" mass="48690" checksum="C8B4F7834B94A913" modified="2018-10-10" version="1">MTTAQGDSNGAVPEPAPAGPPVYRGDLEHRGEYQDIVPKSFWTGFTDTAFFIFAGVASLVLTIMLLTSSFTHSWWGLLLALVFWGFTAYLTLPRFHAIMSRIYVPDYFIGRTRTSDGLLGDPVNLGLIGTEEQIHQAMLNAGWTRADEVTLASSWKIVVSTLTRRSYAEAPVSPLKIFGRVQSFAYQQEVDGNPEKRHHVRFWKTPDGWLLPGGHRVDWLAAGTYDSGVGFSFFTLQVTHRIDAQTDFERDYIVESIQYAYPQTEVEVIKDFSTGYHARNGGGDTIVTDGALPIVTLRNEGLERQDAEARDVRLTSAHDIAEKLPIVLLTASLMLVISSVAELVTSILTVANRHELVSNLTGQGSDTAMVQVLNGPEGDTFMIFTLVAAIAVVVILSLYTCLCCGLLCAVRRRRGGWCCFCWWSASQPKLPQYLRLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0S3</accession>
    <name>A0A2Z5R0S3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative proteasome component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88140">
        <property type="protein sequence ID" value="BAV88140"/>
        <property type="gene ID" value="RA11412_1841"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1841"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="332" mass="36698" checksum="828F6351D1EF6FAE" modified="2018-10-10" version="1">MGAGKTHPKGGPVSGSTDPASATGVPSFSFSQRADHIWEAASTSTSRVRPLINTRDEPHADASKYRRMHVINGDSNMAEPTVLLKIVSTDLVLRMLEDRFPLTSLNIVSVPQALRAISHDMSGSAAFETADGQRYTALSVQRHYLDAARKYVDWHGEHHQHVGYALDLWQRTLDAVHSGDYSSIDTEIDWAIKKKLLDAYISRAQAAGQETSYASARIRQLDLAYHDIDPDRGVYHALVRRQAVKTVLPAGAAEHAIDEPPATRARLRSQFVKAAKAAGEQFTVDWVHMRLNAYPQHTVVCKDPFQTHSEQVDEVVAMLGHKHPEPPAPPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0T4</accession>
    <name>A0A2Z5R0T4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88150">
        <property type="protein sequence ID" value="BAV88150"/>
        <property type="gene ID" value="RA11412_1851"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1851"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="132" mass="14747" checksum="272B568E0FC78D8D" modified="2018-10-10" version="1">MGQHNFPPARVFETFAKENTERPRGIRSFFNAASASGDYTTIMLVGMRSRIDPAGNGEDALDIIHRAFDPCEELPGIDMDPFFDYTLAPAHLYSDGESASQLVFPKLFFNSIEVPEQKLRLLIVTGPHPRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Y6</accession>
    <name>A0A2Z5R0Y6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial proteasome-activating AAA-ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88144">
        <property type="protein sequence ID" value="BAV88144"/>
        <property type="gene ID" value="RA11412_1845"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1845"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="217" mass="23037" checksum="2A0EDA1625D8A40F" modified="2018-10-10" version="1">MESLKNVIVIGATNREDLIDAAVMRPGRLDLKIRINRPDAAGAAEIFALYLTDDLPFDTAEVDRHSSVDAAVQAMISAAVQQLYSRTPANAYAIARVDSAHAKSGAALTGHTLYRGDFASGAVIRNIVDRAKKQAIKEQLDTLITAPGVPPAAGEITGGIGTRHLLEAVRAEFEDQVELPPLPDIEDALAMAGVRGRIVSVEPAHTAARAVPDESKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R134</accession>
    <name>A0A2Z5R134_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">rpsD</name>
        <name evidence="12" type="ORF">I6I94_00515</name>
        <name evidence="13" type="ORF">NCTC10207_01200</name>
        <name evidence="11" type="ORF">RA11412_1895</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037233535.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88194">
        <property type="protein sequence ID" value="BAV88194"/>
        <property type="gene ID" value="RA11412_1895"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1895"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="10">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="95"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV88194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT89158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VEI23103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="210" mass="24142" checksum="46C449097298AD03" modified="2018-10-10" version="1">MAKHNRTRRTVRQSRALGIALTPKAEKYLERRPYGPGQHGRARKKADSNYATQLKEKQRLRAQYNIREAQMRRAYLEAKRVEGQTGKNLVEHLETRLDALVLRSGFARTIAQARQMVVHRHIMVDGVRVDRPSFRVKPGQLIHVHPKSEKTTPFQVAAAGENQAVLPEVPAYLNVEIEKLHAKLERAPKREEIPVVCDEQLVVEYYSRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R187</accession>
    <name>A0A2Z5R187_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88413">
        <property type="protein sequence ID" value="BAV88413"/>
        <property type="gene ID" value="RA11412_2114"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2114"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="84" mass="9659" checksum="31FD0FFEB27778F1" modified="2018-10-10" version="1">MKLPPPDDEEEEELSDGDGLLEEDEELLLDDGLRVGEELLELRECHMIVQCPPSYVPTAIWRDSPYRLYEDSDLYSPSFTMKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1A7</accession>
    <name>A0A2Z5R1A7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sigA</name>
        <name evidence="10" type="ORF">I6I94_10555</name>
        <name evidence="9" type="ORF">RA11412_2228</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88527">
        <property type="protein sequence ID" value="BAV88527"/>
        <property type="gene ID" value="RA11412_2228"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2228"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="5">
        <location>
            <begin position="258"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="5">
        <location>
            <begin position="337"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="5">
        <location>
            <begin position="426"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="5">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT88939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="491" mass="53829" checksum="6B644E187F94140D" modified="2018-10-10" version="1">MSTATSKKAATSEATDEAVADTPQKKTTRTKKTASAKSTTTNSEGAGAKTTKTAAKATTTKKRATKSTTKAAAAKASSSAEDGASDAAETETKPKRTRKTATATKAKAAPKRGRKKKSDDEFDLDLDPDAIDGEPLESEADEEAEEDEEAVAKKEEKKAAEEVAAKGSGFVLTASDDDDAPAQRVVTPGATADPVKDYLKQIGKVSLLNAQQEVDLAMRIEAGLYAEHKLADNPDMDPKLKKELRWVIHDGKRAKNHLLEANLRLVVSLAKRYTGRGMLFLDLIQEGNLGLIRAVEKFDYSKGFKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLARVQRQMLQDLGREPTPEELGKELDMAPEKVIEVQKYGREPISLHTPLGEDGDSEFGDLIEDSEAVVPADAVSFTLLQEQLHSVLDTLSEREAGVVAMRFGMTDGQPKTLDEIGKVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1H2</accession>
    <name>A0A2Z5R1H2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88528">
        <property type="protein sequence ID" value="BAV88528"/>
        <property type="gene ID" value="RA11412_2229"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2229"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="257" mass="28261" checksum="43B8FDBD79968416" modified="2018-10-10" version="1">MMRTLAAGQRTTVGDRMRQLLPAEVAGYLAASLNTYGTINLVTYCAAATLTDSLRVLEGYGGRFTEPAPTTTGEGTAIEPGSYGAPPRRRNTLPSSFLQTLHGKQHRVGSPSGVRTGWHDWVRRTHLTVQRSATDVSQTQTDYAEAMARLLCGTDQTVSPRWERLNALEVLCSLLIPAACGEPLGRLRIVQAWINWMRGTSSYANLLNEEAHRHVQEHTPLDDALHLGLLPLWLGDSARCWRGPARFSVLNVYPVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1M1</accession>
    <name>A0A2Z5R1M1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88637">
        <property type="protein sequence ID" value="BAV88637"/>
        <property type="gene ID" value="RA11412_2338"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2338"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="172" mass="19243" checksum="7B22A1F839109375" modified="2018-10-10" version="1">MHGVTTEYARAHGQPAQQVVWELAGAIGSLFLDGVPVIAFNAAYDFSVLHHEMKRYSIANGELPGGCILDPYIIHKHVIPRKRGNRKLETLAVEHKVQLDNAHTSKDDALAAERLLVKLTERFPAVLDVDAAALHEQQVQWAAQQAADFQAWLRTKPGKENEVIDGRWPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1N4</accession>
    <name>A0A2Z5R1N4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88572">
        <property type="protein sequence ID" value="BAV88572"/>
        <property type="gene ID" value="RA11412_2273"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2273"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="71" mass="8480" checksum="03697B9C3CA7DB11" modified="2018-10-10" version="1">MKDDGTYLWEFYLKWIKQIEVQGNGQWDVQENDRHDDDTFYLHIRHADGGWKILGLSPITGQKDTNQEKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1N9</accession>
    <name>A0A2Z5R1N9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (cytidine/uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could methylate the ribose at the nucleotide 34 wobble position in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88608">
        <property type="protein sequence ID" value="BAV88608"/>
        <property type="gene ID" value="RA11412_2309"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2309"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18094">
        <property type="entry name" value="SpoU-like_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="195" mass="21268" checksum="FC445C1F5C7B713B" modified="2018-10-10" version="1">MVLLWVVYFPILAAVALLGVGYGAGLPWAEQPGCTRYTRGVFKILFYTPEIPGNTGNAIRLAAITGAQLHLVEPLGFTFEDAHLRRAGLDYHDLAVVTVHKTLEDAWDALAPARVFAFTTTAATSYADIAYRPGDVFMFGPESVGLPEKVQQDEHITERVKIPMVPGRRSLNLANSASIAVFEAWRQHGFAGGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1P5</accession>
    <name>A0A2Z5R1P5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome (Plasmid) partitioning protein ParB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86769">
        <property type="protein sequence ID" value="BAV86769"/>
        <property type="gene ID" value="RA11412_0470"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0470"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="41"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="306" mass="34459" checksum="E4ECE73B803656CD" modified="2018-10-10" version="1">MGQALRNTTLTRRPVDFFFGEEVKTPSSSEDLVPVPGAQFAILNISDIHPNRKQPRVDFDEHDMDELVHSVKEIGVLQPIVVRPSREKGHEKYELVMGERRWRATQRAGLPTIPAIVRDTQDNDLLRDALLENLHRSQLNPIEEAAAYQQLMEEFGTTQDQLAKRIGRSRPQISNTIRLLKLPALVQRRVAAGVLSAGHARALLMLTDQAQIETLAQKIVNEGLSVRAVEELVAAASGAEDKKQRKEPRPQKHRERLDYIADAFADKLDTSVKISLGARKGKMTIEFANVDDLNRIIKTLDTNFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1S6</accession>
    <name>A0A2Z5R1S6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent DNA helicase SCO5184</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88633">
        <property type="protein sequence ID" value="BAV88633"/>
        <property type="gene ID" value="RA11412_2334"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2334"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="78" mass="8747" checksum="E1BB882E2A5374B4" modified="2018-10-10" version="1">MKQVLKLAGECAEHLVAPQTVIEFCTAQIAAYESLSTPGPRKTANDTLRQLQTKIILARMVQRYARVKARMQVLDYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1T9</accession>
    <name>A0A2Z5R1T9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hemC</name>
        <name evidence="11" type="ORF">I6I94_10010</name>
        <name evidence="10" type="ORF">RA11412_2354</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88653">
        <property type="protein sequence ID" value="BAV88653"/>
        <property type="gene ID" value="RA11412_2354"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2354"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="8">
        <location>
            <begin position="7"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="9">
        <location>
            <begin position="282"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT88844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="367" mass="38245" checksum="D5DCF06363ED3FAB" modified="2018-10-10" version="1">MSETYLLGTRGSALALTQSTLAAEHVTAASHAHEGTTGVEFELVTVKTEGDTLAGPLATLGGTGVFAAALRQRLLAGNNGEGVDMAVHSLKDLPSAPCPGLVVAATLEREDPRDALVARDQLTLDTLPTGARVGTGSPRRAAQLRLLRPDLEIVDIRGNVGTRIARVKGLEEHGARQVMVQGSAETDRQAHTGVGAETTGDCDAVVLAVSGLKRLNKEDVITEYLDPTRMLPAPGQGALALEVRESEFANPDIASLTETEISRPVRSLGAALIAADHFETRLAVTAERALLRRLEAGCAAPIGAYAHVIEGDLVLTAIVADPRGTECIRHSAATVELDIPGAERLGVHVAEDMLQMGAAALAGLEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1U6</accession>
    <name>A0A2Z5R1U6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DEAD/DEAH box helicase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Putative ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I6I94_09975</name>
        <name evidence="11" type="ORF">RA11412_2364</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88663">
        <property type="protein sequence ID" value="BAV88663"/>
        <property type="gene ID" value="RA11412_2364"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2364"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="42"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="236"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="422"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="485"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV88663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT88838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="536" mass="58258" checksum="8E74F9FF7822D684" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Y2</accession>
    <name>A0A2Z5R1Y2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09765</name>
        <name evidence="2" type="ORF">RA11412_2419</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88718">
        <property type="protein sequence ID" value="BAV88718"/>
        <property type="gene ID" value="RA11412_2419"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2419"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="144" mass="15728" checksum="FD68F07D8E458C5E" modified="2018-10-10" version="1">MVVPFAIAGVLMALAVGAHVFVGTRETLALRPTENRPTADAAASTPSTRGELTRHWAQAMCVFQLVSVDLLLVTIAALLLAFTDVLPAKRDIGLFIAAYLGAWGVVWLVQLAAVKVERRTYYMLGHWMLFFLCAALMVWGAFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R233</accession>
    <name>A0A2Z5R233_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09495</name>
        <name evidence="2" type="ORF">RA11412_2479</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88778">
        <property type="protein sequence ID" value="BAV88778"/>
        <property type="gene ID" value="RA11412_2479"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2479"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="96" mass="10261" checksum="C6040C53D1EB3A7D" modified="2018-10-10" version="1">MSGYSPVPKPRRGHRRVSGAGAPAEAEPRIARVNAPEPGRVQRVKPSGGQRAASGQQGTGATRGVPGGRSQQVLSADELARLQWVQEMKEQKPPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R241</accession>
    <name>A0A2Z5R241_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">M15 family metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_09280</name>
        <name evidence="4" type="ORF">RA11412_2528</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88827">
        <property type="protein sequence ID" value="BAV88827"/>
        <property type="gene ID" value="RA11412_2528"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2528"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340110" evidence="2">
        <location>
            <begin position="30"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="VanY" evidence="3">
        <location>
            <begin position="107"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="265" mass="28110" checksum="514ECEC5F54A8D5B" modified="2018-10-10" version="1">MTVHRTADIFSRRAALALAGGGAGALLLAACGSGDGTSGVSNSASSTGSASEGSGGAGSTAAAGSSPSAASASTETNPGSLRVIVNKMRPFSPKEWEPEDLVDFEGHQLRAEAAEAAKKMMRAAKQEGVELTVSSAYRSYAVQQQTYQHWVEVNGKQKADTLSARPGYSEHQTGLAIDFGSAQEGCLLEECYKDTKAGRWLAEHAPEYGYILRFPQQQQGITGYIFEPWHYRYLGVELAKEYTASGADTLEEFFGTGAAPNYEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2H1</accession>
    <name>A0A2Z5R2H1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inosine-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88802">
        <property type="protein sequence ID" value="BAV88802"/>
        <property type="gene ID" value="RA11412_2503"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2503"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005992">
        <property type="entry name" value="IMP_DH-rel2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF85">
        <property type="entry name" value="PTHR11911:SF85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01304">
        <property type="entry name" value="IMP_DH_rel_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="2">
        <location>
            <begin position="17"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="359" mass="38766" checksum="EA1E30B0EC02639B" modified="2018-10-10" version="1">MSDIQIGLSKSARRTFALDDVALVPTRRTRDRRDVDTSWQIDAFRFDTPIVGAPMDSVMSPKTAIALGQLGGLGVLNLEGLWTRYEDPQPLLDEIAELPEADPASSTRRMQQIYAEPIKPELITARLEQIRDSGVIVAGSLTPQNTQEHYETVVQAGVDVFVIRGASVSAEHISTSHEPLNLKKFIYELDVPVMVGGVAGYSQAKHLMRTGAAGVLVGFGGGSAMTTRKGLGISAPMATAIADVAAARSDYLDESGGRYVHVIADGGLSRSGDLVKALALGADAVMIGAPLARASEAPGQGWYWGNEAHSRDFPRGVRTPWVWLELSKRCCMGPRTMWMVPAILWAPSNAQWRTAATWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2H8</accession>
    <name>A0A2Z5R2H8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88965">
        <property type="protein sequence ID" value="BAV88965"/>
        <property type="gene ID" value="RA11412_2666"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2666"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="300" mass="33271" checksum="8ADFA0551FABD3B6" modified="2018-10-10" version="1">MPPNLPTPLMALPEVELTPLPTRTSAITQEATIGVQAMIRPQVPVHMGQTLGVLQRGAADAAYRITAREPGAEMVWVTARTPQLMLPVTLRFSRAADDTPEPALPALHRLLMRPILVRAWARLSPEMFLEEPQARADVEALVRSCPAWLGLGDSWESFTASAGYASLPRSLRRAHREHPGLRLSASDQLDRHVFAAIIEQRVTLKEAFQTQRDVLIRYGEPAVESGYRDQPAGMRVHPTARTLGAIPDWGWHRVGLMRHVITRCAPTPAPPILCTVLPLRARWLILPPPWGRCTGWARGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2J7</accession>
    <name>A0A2Z5R2J7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplM</name>
        <name evidence="6" type="ORF">I6I94_09255</name>
        <name evidence="7" type="ORF">NCTC10207_01750</name>
        <name evidence="5" type="ORF">RA11412_2533</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888736.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88832">
        <property type="protein sequence ID" value="BAV88832"/>
        <property type="gene ID" value="RA11412_2533"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2533"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VEI23821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="147" mass="16340" checksum="961291CCC346E61F" modified="2018-10-10" version="1">MRTYTPKPGEIERQWHIIDATDVVLGRLASQTAILLRGKHKPTFTPNVDTGDFVIIVNAEKVALTGAKLEQKRAYRHSGYPGGLKSVNYAELLETNPVRAVEKAVKGMLPKNKLAAQQIKKLKVYAGPEHPHAAQQPKTYEFNQVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2M5</accession>
    <name>A0A2Z5R2M5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">rplP</name>
        <name evidence="11" type="ORF">I6I94_09130</name>
        <name evidence="12" type="ORF">NCTC10207_01775</name>
        <name evidence="10" type="ORF">RA11412_2563</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887759.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88862">
        <property type="protein sequence ID" value="BAV88862"/>
        <property type="gene ID" value="RA11412_2563"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2563"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="9">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT88675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VEI23863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="138" mass="15702" checksum="BAEF2FBB8B047207" modified="2018-10-10" version="1">MLIPRRVKYRKQHHPKRHGLAKGGTEVSFGEWGIQALSPAYVTNRQIEAARIAMTRHIKRGGKVWINIYPDRPLTKKPAETRMGSGKGSPEWWVANVKPGRVMFELDGVSEEVAREAMRLAIHKLPMKARIVRREGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2R8</accession>
    <name>A0A2Z5R2R8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA pseudouridine synthase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88834">
        <property type="protein sequence ID" value="BAV88834"/>
        <property type="gene ID" value="RA11412_2535"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2535"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="79" mass="8962" checksum="89BA6C6833DB997E" modified="2018-10-10" version="1">MPANFDARFSATGRRYIYRIADGQQAGPDPLRRTFTWGVPERLTPSVLNEAAADLLGLRDFLSFCKPVRVLRLFVNCVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2S2</accession>
    <name>A0A2Z5R2S2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipid A export ATP-binding/permease protein MsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87189">
        <property type="protein sequence ID" value="BAV87189"/>
        <property type="gene ID" value="RA11412_0890"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0890"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="107" mass="11367" checksum="85C9C8115EDF0A67" modified="2018-10-10" version="1">MGATGSGKSTALTLVPRFYSPTSGRILLGREDIADMPLPVLRAQTAFVFEEAVLFSGTVRQNVLMGVRGEYSDEELEQTLTGALELAACDFVADLPEGVDTVIGEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2W4</accession>
    <name>A0A2Z5R2W4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alkanal monooxygenase alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87229">
        <property type="protein sequence ID" value="BAV87229"/>
        <property type="gene ID" value="RA11412_0930"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0930"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="201" mass="22360" checksum="DBE7273826A534FA" modified="2018-10-10" version="1">MARRHLDLFMKAIQGEGMAPSVRVQGKYAPVQPQSPGLSERIWWGAGTDNTAVWTAQQGLNLMSSTLMLEDKGMPFDQQQAEQIRLYREAWVKAGHTRVPRVSVSRSVIPIIDAESARYFGRRAEEDSQDYTGIIDNTFSRFGRSYIGDPNLIAEELARDAAVQAADTVLLTVPNQLGVDFNLRLLESIVKDIKPALTVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R317</accession>
    <name>A0A2Z5R317_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">rplB</name>
        <name evidence="8" type="ORF">I6I94_09110</name>
        <name evidence="9" type="ORF">NCTC10207_01779</name>
        <name evidence="7" type="ORF">RA11412_2567</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887702.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88866">
        <property type="protein sequence ID" value="BAV88866"/>
        <property type="gene ID" value="RA11412_2567"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2567"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="125"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VEI23871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="278" mass="30509" checksum="ED422488D8186A52" modified="2018-10-10" version="1">MGIRKYNPTTPGRRGSSVADFTEITRSTPEKSLVRPLPKKGGRNNTGRITARHKGGGHKRQYRLIDFRRHDKDGVNARVAHIEYDPNRTARIALLHYFDGSKRYIIAPNKLAQGDIVESGPAADIKPGNNLPLRNIPVGTVLHCVELRPGGGAKLARSAGASVQLVAKEGKYGQLRLPSGEIRNVDVRCRATVGEVGNAEQSNINWGKAGRNRWKGIRPTVRGVVMNPVDHPHGGGEGKTSGGRHPVNPNGKPEGRTRRPNKESDKLIVRRRRTGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R360</accession>
    <name>A0A2Z5R360_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88931">
        <property type="protein sequence ID" value="BAV88931"/>
        <property type="gene ID" value="RA11412_2632"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2632"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="38" mass="4142" checksum="18AE6F0982FE0CE5" modified="2018-10-10" version="1">MDNIFALEIFFICLLGLASICIAIGALKVLLGLYRGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R363</accession>
    <name>A0A2Z5R363_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polyphosphate kinase</fullName>
            <ecNumber evidence="6">2.7.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">RA11412_2637</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88936">
        <property type="protein sequence ID" value="BAV88936"/>
        <property type="gene ID" value="RA11412_2637"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2637"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="8">
        <location>
            <begin position="59"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="7">
        <location>
            <begin position="175"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="10">
        <location>
            <begin position="389"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="9">
        <location>
            <begin position="562"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV88936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="671" mass="74638" checksum="85D70E6315B32B6A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R368</accession>
    <name>A0A2Z5R368_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87379">
        <property type="protein sequence ID" value="BAV87379"/>
        <property type="gene ID" value="RA11412_1080"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1080"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="144" mass="15733" checksum="2D8C542B7E233749" modified="2018-10-10" version="1">MTLQTGILSPVGSGRSSMSERFNELSMLARLGVARVSAPRWAWVVPALMVVLAGILRFVYLAHPNAIVFDETYYAKDAYSYLHYGYELNWTKEANGTFVAGSPSGLLTDSPEYVVHPPLGKWMIAAGMAILGIITRLGGVLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R375</accession>
    <name>A0A2Z5R375_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfur carrier protein adenylyltransferase ThiF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89050">
        <property type="protein sequence ID" value="BAV89050"/>
        <property type="gene ID" value="RA11412_2751"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2751"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="242"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV89050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="317" mass="34029" checksum="41C16B85AAFD64F8" modified="2018-10-10" version="1">MRQDRLPGFDQQAVANAHVLVIGAGGLGCPVVQALAAAGVGSIALVDHDVIELSNLQRQPLFGIADCGRAKAEVAAHRAREIAPALRVTVYRRYLEASWILDLLAEENPAVIVDCTDTFETKYLIADAAEITGIPLVWGSVLRYQGSVSVFRTGSVHLRDLFPTTPETLESCAEAGVLGATTAVIGSLMATETLKFLAGLPTLEGRLLTYEALSGTFQNFALSPDPERAPVTDLSAYELPKILLDVREQNERETQVKYPDSLHLPLSAATEDAVRSMLKPLAGERVGVFCKSGARAAKFIQEWDAVAADYGVRLTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R385</accession>
    <name>A0A2Z5R385_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper resistance protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89070">
        <property type="protein sequence ID" value="BAV89070"/>
        <property type="gene ID" value="RA11412_2771"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2771"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="238" mass="24403" checksum="44506A77A9B25089" modified="2018-10-10" version="1">MATMSSQPQKTEAGPKSAAVRPGLSAPWIAAYAGVGLLVLIISLRITAANAATDLADAGALVRWGLPITEVVHNFAMATTMGALIFAMGIIPRYAADAAGTRHGTRSAHNTAEKEYKPFADVLNLAAASAVLWTLAALAVLILSYADISGRPIGSGAEYASELISYVTTLDAGKEKGMTVVVAAVVATACFGVRSLMGLFFIFMISLVGIADMALSGHSSGGQDHMGAVNSLGLHLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R398</accession>
    <name>A0A2Z5R398_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03510</name>
        <name evidence="2" type="ORF">RA11412_1140</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888214.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87439">
        <property type="protein sequence ID" value="BAV87439"/>
        <property type="gene ID" value="RA11412_1140"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1140"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_tran_28_C" evidence="1">
        <location>
            <begin position="91"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="236" mass="25973" checksum="6805E4D2D9B4E0BD" modified="2018-10-10" version="1">MSIHNFPDVSVSDANSGVPVLTPNTDPVNIPTKTYDLVISLGTDYHRFDRLLRWVDAYLKENPHLSCLVQHGHTAPIERGENVRLMPAGDLMGYYATASVVVVQGGPGSIQDARRTGAIPLVVPRRAEFDEVVDNHQVPFADLMEKRGHAVVVNSRAELFDKLNLALANPSLFRSAEPYVAAPEVSAEQLSEALHDLLTGRSHRTEGYVTRFKNAARAHFLGKREMARISSLTPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3A8</accession>
    <name>A0A2Z5R3A8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87469">
        <property type="protein sequence ID" value="BAV87469"/>
        <property type="gene ID" value="RA11412_1170"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1170"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="62" mass="6344" checksum="1AAC0DF655372B62" modified="2018-10-10" version="1">MQAGASAQEQNPILATASRLLNRRQWLGASLKPGPGHGVGHGLCNSNVPSACIVARALAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3E4</accession>
    <name>A0A2Z5R3E4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">rpsO</name>
        <name evidence="8" type="ORF">I6I94_03080</name>
        <name evidence="9" type="ORF">NCTC10207_00660</name>
        <name evidence="7" type="ORF">RA11412_1250</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888961.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87549">
        <property type="protein sequence ID" value="BAV87549"/>
        <property type="gene ID" value="RA11412_1250"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1250"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VEI22579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="89" mass="10443" checksum="2906CB62411121D6" modified="2018-10-10" version="1">MALDPAIKQEIIKEYATHEGDTGSPEVQIAVLSRRISDLTEHLKFHKHDHHSRRGLMMLVGRRRNLLGYLKSIDIERYRSLIERLGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3Q3</accession>
    <name>A0A2Z5R3Q3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87799">
        <property type="protein sequence ID" value="BAV87799"/>
        <property type="gene ID" value="RA11412_1500"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1500"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="SLH" evidence="4">
        <location>
            <begin position="199"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="4">
        <location>
            <begin position="263"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="317" mass="34709" checksum="4A62C9D369AE5AAC" modified="2018-10-10" version="1">MQDTPENRYPAQVINLSFGSYLNSGSKCFKGYQDIFDELHAKGIVVVASAGNKNLDVKYFTPANCNHVISVSSTTRMGERPVASYGSSVSISAPGGTHAPNQGIFSTFNTGMISVGEHNYSENAGTSMAAPHISAIAALAKSVNPDATPDRILSAMQKSAQNRPIQNCDQYSCGPGIVDAGKTLEYLDNPVKNPDPWNNGPIFYDIHKNMPFYQEIQWIGAQGITTGYPDGTFHPADNVERGAMAAFFYRYAGQPEYVMPSTSPFRDVSVGSSFYREITWLHSTGIANGWQDGTYRPVDPIRRDAMAAFIYRYAHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3R0</accession>
    <name>A0A2Z5R3R0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_01905</name>
        <name evidence="5" type="ORF">RA11412_1540</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888653.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87839">
        <property type="protein sequence ID" value="BAV87839"/>
        <property type="gene ID" value="RA11412_1540"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1540"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="13"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="253" mass="27509" checksum="BEAFB51294B7523A" modified="2018-10-10" version="1">MTTSTIPAGTPAVATRNLFKTYGKGEATVHALNNVSVDFEHGKFTAIMGPSGSGKSTLMQTLATLDAPDRNPQTIIRIGGTELYGQKDNQLTEFRREHVGFIFQAFNLVPTLTAGQNIDLPLGLASKKPDPVWRDYLVQTLGLQNRLDHRPEQLSGGQQQRVAIVRALLARPEVVFADEPTGNLDSNSGSEVLRLLRDAATEHQQTILMVTHDAHAASYADRVVFLKDGMIAGEMLNPTHDAVLQAMGQLEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R404</accession>
    <name>A0A2Z5R404_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">pyrB</name>
        <name evidence="10" type="ORF">I6I94_00585</name>
        <name evidence="11" type="ORF">NCTC10207_01186</name>
        <name evidence="9" type="ORF">RA11412_1880</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037234497.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88179">
        <property type="protein sequence ID" value="BAV88179"/>
        <property type="gene ID" value="RA11412_1880"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1880"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="164"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VEI23089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="333" mass="36651" checksum="31F72A832B397CEE" modified="2018-10-10" version="1">MKHLLDTRDLTRTQAIEILDVADYMAQVKAENRKLNVLAGKTVVNLFFEDSTRTRLSFESAEKRLGADITNFAARGSSVSKGESLKDTAQTLKAISADAFVIRHSASGAPQRLAEAGWTDIPVLNAGDGTHAHPTQALLDAVSLRQFKAQRDGLDSPRGTDLSGMRVLIVGDILHSRVARSNLWLLKNLGADVAFVAPPTLLPVHTERWKQDWGLEVFHDFDDAIATKPDAVMMLRIQKERMNAAYFPSAEEYTALWGLTKERFENLLAQPQEVAILHPGPMNRGLELCAEAADSQNAWVLRQVSNGVAVRMAVLYLLLTDGSSEKLYSGDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4H4</accession>
    <name>A0A2Z5R4H4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_10470</name>
        <name evidence="3" type="ORF">RA11412_2250</name>
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    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88549">
        <property type="protein sequence ID" value="BAV88549"/>
        <property type="gene ID" value="RA11412_2250"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2250"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="142" mass="15723" checksum="60E1BB3793C36AD6" modified="2018-10-10" version="1">MSSIFSKIIAGEIPGRFVWKDEKCVAFMDIMPASHGHLLVVPREEIDRWPDLPPELAAHLFAVAHKISQALDRAFDKDRVALMIAGFDVPHTHIHLFPADSMAEYDPANALKNLSTEELDADAATVRAALRSLGHNEFVPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4S5</accession>
    <name>A0A2Z5R4S5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88819">
        <property type="protein sequence ID" value="BAV88819"/>
        <property type="gene ID" value="RA11412_2520"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2520"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031423">
        <property type="entry name" value="Phosphatase_SCO2771"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15698">
        <property type="entry name" value="Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="258" mass="28717" checksum="5456B5305234D9A9" modified="2018-10-10" version="1">MTRHEFAAYLDSARITGDVATPRENNLSHIQGFLDHNEHLEFGVIWSKDWTYDEVFEVMVRRAGLNPDRSHVQGQDTIGAAQCIDALEEYARIFGDAVRARQKILFATGHPAGLFPIYAELARVAELAGATVLRIEQGERFLDGDIRQIMGVVMFEQYGNLQHTHFPGPMRIALAQLRERGELPDLVVSDHGMAGYAASQQKLPTLGIADCNDPGLFIAAEQGDLPVCVPMDDNVPPNRYEPLIDFVLDRAELTGFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R505</accession>
    <name>A0A2Z5R505_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89019">
        <property type="protein sequence ID" value="BAV89019"/>
        <property type="gene ID" value="RA11412_2720"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2720"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV89019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="4774" checksum="B1056D2562E3A29A" modified="2018-10-10" version="1">MLNVTDCAKNAPGQYSPSPQYEPEKSTGKKNSADENEAESKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVI4</accession>
    <name>A0A2Z5QVI4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4956 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_07805</name>
        <name evidence="3" type="ORF">RA11412_0092</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86391">
        <property type="protein sequence ID" value="BAV86391"/>
        <property type="gene ID" value="RA11412_0092"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0092"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032531">
        <property type="entry name" value="DUF4956"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16316">
        <property type="entry name" value="DUF4956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="242" mass="26346" checksum="012AA6CF1C321BFB" modified="2018-10-10" version="1">MHLVSMVIADLIAIAALCTIYLVRHSRRELVVSYTIINFGVFVVTEALSFASGTSAGMGLGLFGVLSIIRLRSTPLAQREVAYYFVSLALGLIAGVRLDPEYMAYALMAMLVIIMAVVDLPFFDNKQKTQIITVDRAISDPEELKTYLNQKLSYEVLSVKVSELDMVNDTTRAEVSYNPDPPAEDTTAEQGNTPDYAVTAKAQNTPTQQGAGATQGYGNQAQGYASSQQGYGHHLHEASRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVL6</accession>
    <name>A0A2Z5QVL6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Rrf2-linked NADH-flavin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07630</name>
        <name evidence="2" type="ORF">RA11412_0139</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86438">
        <property type="protein sequence ID" value="BAV86438"/>
        <property type="gene ID" value="RA11412_0139"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0139"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="209" mass="22603" checksum="050D02477CFC0726" modified="2018-10-10" version="1">MKIAVIGANGKSGTLVVREAVERGHEVTAIMRSEHPTQAQHTLIKDVFALTRSDLSGFDAVVDAFGAWTPESLHLHKDHLVHLADALSGTQTRLLVIGSAGSLYPDSTTDQRLVDSPAMPEEFKPLATAMAQAYDALRIRDDVAWTYLSPALVFNPEGERTGEYQLAGDVLTMNAAGQSEISYADFAVAVLDLIESGEHQCERVSVVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVN5</accession>
    <name>A0A2Z5QVN5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86453">
        <property type="protein sequence ID" value="BAV86453"/>
        <property type="gene ID" value="RA11412_0154"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0154"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="46" mass="4900" checksum="371BAD2F1EF5561C" modified="2018-10-10" version="1">MELWLDDCDGWALPLLFPPSVFGALLEGLAAALPAYALEPAELGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVP0</accession>
    <name>A0A2Z5QVP0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VanZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_07525</name>
        <name evidence="3" type="ORF">RA11412_0168</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86467">
        <property type="protein sequence ID" value="BAV86467"/>
        <property type="gene ID" value="RA11412_0168"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0168"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="49"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="191" mass="20561" checksum="ECA8F9D14A3F2118" modified="2018-10-10" version="1">MTNRDAFGAVTFRGAEHLTDSHTYSSAVSYPPRSARYARLWRWALIVLFVAYLCVVGSIVFAPVHVDSGEAGGSLREFLERGHAQGWLPGLITYESVERAANVVMFFPSGVLLGLLLPRGAYPYIMVGGYVASLGIESIQHMMPNRTADVSDVLMNGTGTLLGVLAVRAGAAVWGRLRRGTTEPEGGRGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVY6</accession>
    <name>A0A2Z5QVY6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN dependent NADH:quinone oxidoreductase</fullName>
            <ecNumber evidence="6">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Azo-dye reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azo compound oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="6">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">azoR</name>
        <name evidence="9" type="ORF">I6I94_06970</name>
        <name evidence="8" type="ORF">RA11412_0276</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:55874"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="6"/>
    <dbReference type="EC" id="1.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86575">
        <property type="protein sequence ID" value="BAV86575"/>
        <property type="gene ID" value="RA11412_0276"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0276"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="209" mass="22966" checksum="2E55342A44F68578" modified="2018-10-10" version="1">MQTLIINAHPDPRNKTAYCTNRLVDCLTEKLPDATVLNLYNEDIPELTAETLPVFNGAYSGDGKDAELSKGAQHFLARNAELLEQFKAADRVIIAMPMHNFTVTSRLKDYLDNIIVPGQTFQYTREGPQGLMGGHKALLVQSSGSVYSTGPLAPWEQSYPFLQTAFGMLGFDSTDIVRAEGTMDPNIGPDVAVERACAELEQKLPEFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVZ5</accession>
    <name>A0A2Z5QVZ5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86566">
        <property type="protein sequence ID" value="BAV86566"/>
        <property type="gene ID" value="RA11412_0267"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0267"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="414"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="476"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="542"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="598" mass="65113" checksum="9A3BA8959DBFE23E" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW18</accession>
    <name>A0A2Z5QW18_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF2029 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_06870</name>
        <name evidence="8" type="ORF">RA11412_0299</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86598">
        <property type="protein sequence ID" value="BAV86598"/>
        <property type="gene ID" value="RA11412_0299"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0299"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="443" mass="48715" checksum="DABF28AB31AB5D27" modified="2018-10-10" version="1">MTTAPPVQNPTPNTTVAGKIALAALALTVVGWLIYIEFTGGLDFNVYRLGAMTIFDNEGMHKDLYARDLLDYGALKLPFTYPPFAALLFMPFAFLPFGVGVGIMYTISIGVAWWMATLIYDYATSRGYHIPFQDKLGRYGTIAVLTFIIILSGPWRRGLALVQVNPIILILVLADFLRPAKRIPRGALIGIAGGIKLTPLAFGLILLMRKDWRGIFTLGASFAATVIIGFIFLPHEALTFWTSAVSDPSRVGNINFLDNISIQGWLMHLGLRDPLLKPAYYGLVLATIVLFAALLHQLNRRKLVLSQVAVGGFLMVSISPISWSHHNVMFPLILMALIVDAFPRFYAHLPAWANRAARILTWVALIGLYISPMWLGASLWGSFSDLDNIYQHALLFSTVPILCLYLVMITWAVAALTPAVRTAEEDDLFIAPPPGAAPDAKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW35</accession>
    <name>A0A2Z5QW35_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">metE</name>
        <name evidence="15" type="ORF">I6I94_06795</name>
        <name evidence="14" type="ORF">RA11412_0319</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86618">
        <property type="protein sequence ID" value="BAV86618"/>
        <property type="gene ID" value="RA11412_0319"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0319"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Meth_synt_1" evidence="13">
        <location>
            <begin position="9"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Meth_synt_2" evidence="12">
        <location>
            <begin position="440"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV86618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QQT88252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="773" mass="85117" checksum="A669D91B4F40D70A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW41</accession>
    <name>A0A2Z5QW41_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mobile element protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86553">
        <property type="protein sequence ID" value="BAV86553"/>
        <property type="gene ID" value="RA11412_0254"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0254"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="9"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="318" mass="35641" checksum="FEF26C1E292092E2" modified="2018-10-10" version="1">MMSTQHNYAGIDIAKRNFVIAVSSLSKTKTETNNPKGIAHTVEYLKKHKVALVVMESTGGLEIPAAKAIHRSGIAVIIANPRQTHQFAQSQSLTKTDAKDAQMLAFFAQMTAQKEGWQTMLYHPPTEAEEVLEALVNRRNQLVDMRTAEKNRLHQVHETQVESVKQLIAHFDRLIDELDKQIDDHTHTHFDGKAQVAEQIKGIGSITTATLMAMLPELGRLSHKRIASLVGIAPHPRESGETKFKSRCFGGRSAVRKALYMATVVATRFEPLIRDFYQRLLSKGKPYHASETENLSGYIPWVGGSVILTWLPIRRIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWD4</accession>
    <name>A0A2Z5QWD4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86690">
        <property type="protein sequence ID" value="BAV86690"/>
        <property type="gene ID" value="RA11412_0391"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0391"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="59" mass="6369" checksum="0F12D4E3EE32A12E" modified="2018-10-10" version="1">MGFMFLLGPSRRYGEEIAVLPAVAVLAVEVALCVIMIVAAQKTLNNRAVAKAAIYYNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWK5</accession>
    <name>A0A2Z5QWK5_9MICC</name>
    <protein>
        <submittedName>
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    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86604">
        <property type="protein sequence ID" value="BAV86604"/>
        <property type="gene ID" value="RA11412_0305"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0305"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="84"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="247" mass="26394" checksum="71909BFCE182A242" modified="2018-10-10" version="1">MWAASGSAAGCVILEGMASEKSRAGFLTKFVAGFMANWQVIASVVLLGGGVVGLAATYDEYCQVTDLTYAPAEVREDLLRGASATGYRPGILAAQLETESHWQVGAVSDAQAQGIAQFTDAAWAQWGQGGDRRDPHDAIAAQSRYLVGLKERLAKYAANDDELLDLVLAGYNAGPGAVEEYKGIPPYPETQNYVQKIRSLADTKYKQTCTPDRRFKQSQIVRADAPVPSSAAATPNISAQAAGLYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWP6</accession>
    <name>A0A2Z5QWP6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_06700</name>
        <name evidence="3" type="ORF">RA11412_0345</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 5">JCM 11412</strain>
        </source>
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    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86644">
        <property type="protein sequence ID" value="BAV86644"/>
        <property type="gene ID" value="RA11412_0345"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0345"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033776635" evidence="2">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="183" mass="19427" checksum="8737EF4F4F59AB83" modified="2018-10-10" version="1">MRKTCVVGVLVAAVFLGGCSSQGSSGSSGQQSSSSPAAPVVGASGSSSGAEDNDRYGHYGEPANSPGPGAYAGWSKEEQKTATEFAVSSMRIFAMKTDAKTWHLYMDPRVTDGYKKQLERYNPQYGSVNTVYQAVYTEFPPDAKKAVVRVETDAGVWVVHLQREGAGEAPKVALIEPLTLKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWV5</accession>
    <name>A0A2Z5QWV5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_05680</name>
        <name evidence="1" type="ORF">RA11412_0603</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
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    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86902">
        <property type="protein sequence ID" value="BAV86902"/>
        <property type="gene ID" value="RA11412_0603"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0603"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="99" mass="10988" checksum="9FFFEF9B942AFEBE" modified="2018-10-10" version="1">MGAETLTGRIVNAIDLIDGILDAGSIRDYTSRDQLIFMREQLTSMASHLRHRTAPAAGAHALMSRMVVDSWPLDSTLGRQLVDIEDDYLALLQGTRRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWX9</accession>
    <name>A0A2Z5QWX9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86826">
        <property type="protein sequence ID" value="BAV86826"/>
        <property type="gene ID" value="RA11412_0527"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0527"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4797" checksum="2D881D992263FC91" modified="2018-10-10" version="1">MPYLPEAAVAPETIAGERENTCLRPVTVWRRYALVPSYWWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX52</accession>
    <name>A0A2Z5QX52_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NCTC10207_00191</name>
        <name evidence="2" type="ORF">RA11412_0709</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87008">
        <property type="protein sequence ID" value="BAV87008"/>
        <property type="gene ID" value="RA11412_0709"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0709"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI22125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <sequence length="62" mass="6538" checksum="926C7B0C829EEEF9" modified="2018-10-10" version="1">MKTGAWVLALFAIAGLIAVVLIDGPLRWLAFGETLMTGFIALGLVVVLALGWGENKPAEIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX99</accession>
    <name>A0A2Z5QX99_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_04930</name>
        <name evidence="2" type="ORF">RA11412_0776</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888509.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87075">
        <property type="protein sequence ID" value="BAV87075"/>
        <property type="gene ID" value="RA11412_0776"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0776"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="116" mass="12678" checksum="3919AB5DDCB5FB68" modified="2018-10-10" version="1">MAVKRIVTNLAADKPESAAAFYRDILGLELLMDHGWIQTYGNAETTTVQVSIASEGGSGTPVPDLSVEVDNLDEILARIHTAGITLEYGVAEEPWGVRRFFVRDPLGNLVNILQHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXE0</accession>
    <name>A0A2Z5QXE0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">L-proline glycine betaine ABC transport system permease protein ProW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_04765</name>
        <name evidence="6" type="ORF">RA11412_0809</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87108">
        <property type="protein sequence ID" value="BAV87108"/>
        <property type="gene ID" value="RA11412_0809"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0809"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="25"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="230" mass="24537" checksum="3F6BC8BB43BC3DBB" modified="2018-10-10" version="1">MNLLLADSMHWDWLGNNIQRVLDLTLNHLYQGIIPVLVGTALSIPVARYASRRRAREDGAKTYRSGAHALVHGFGLLYTIPSIALFVLMPLILGTSIISPVNVLVALTIYTMALMVRSGVDAFNAVPEHVVESSRALGYTPARAFFTVELPLALPVLFAGIRVATVANIAMVSVGAVIGVSSLGTLFTDGLARSIPAELITGVVLSAALAYLADALLAFTARRLTAWRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXH9</accession>
    <name>A0A2Z5QXH9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Biliverdin-producing heme oxygenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Heme oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_04635</name>
        <name evidence="3" type="ORF">RA11412_0843</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87142">
        <property type="protein sequence ID" value="BAV87142"/>
        <property type="gene ID" value="RA11412_0843"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0843"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="PTHR10720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000343">
        <property type="entry name" value="Haem_Oase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="217" mass="24181" checksum="FCB8D9569B724A09" modified="2018-10-10" version="1">MTTTCAPETTNERFSARLKAGTKNVHDNAEHSTFMEDLMGGKLDTAAYLRLINQYTYIYEALEAISANLREAGNPITDPFTIEGLDRAASIRNDIRALGQQDIDAPLSATIEYVERINATANVPERFLAHHYLRYLGDLSGGQAIAALVARHYGIPAKALSMYRFTELPKPKIFKDGYRELLDNAPLTEEQRQALIDETVEGFRINASLFAQLGRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXI9</accession>
    <name>A0A2Z5QXI9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="1 2" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87167">
        <property type="protein sequence ID" value="BAV87167"/>
        <property type="gene ID" value="RA11412_0868"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0868"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="570" mass="64312" checksum="74B6B4E4030EEE92" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXK3</accession>
    <name>A0A2Z5QXK3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-coenzyme A synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87073">
        <property type="protein sequence ID" value="BAV87073"/>
        <property type="gene ID" value="RA11412_0774"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0774"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
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        <location>
            <begin position="61"/>
            <end position="141"/>
        </location>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="193" mass="20994" checksum="8547F6BA27E84987" modified="2018-10-10" version="1">MARTVWGDPQRYLNSYWKHYGTRGWFLAGDGAKVDDEGNVYILGRIDDVINISGHRLSTIEIESALVTHPAVVEAGVCPVEDELTGHQAVAYVTLTDEGRALTEDELKAALTEHVREHIGPIAKPKDVVAVADIPKTRSGKITRRLLGELYQGHKLGDISSLQNEEALGAIAQVLVDTGRVNPDAFTEEQAAA</sequence>
</entry>
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    <accession>A0A2Z5QXN6</accession>
    <name>A0A2Z5QXN6_9MICC</name>
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        <submittedName>
            <fullName evidence="2">Oligopeptide ABC transporter</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87131.1"/>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87131">
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    </dbReference>
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    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="28"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="262" mass="29450" checksum="515AFF8E082A17AD" modified="2018-10-10" version="1">MSNIDIRKGTALGVSDYELNPDKIPLPVRKAIVAGINREQIQKIRFEKIGWNEKAPGSMCFLPLQEGYKDSYPTEIGEDVAKKILEDAGYKKDGDFYAKDGKKASYELFTFGDDQDVKTTSQFFSDQMKKIGIELKIVNRANSELTKVSTERSYGIKSAGYGITTNPVDSAYYFYRSEINNGHGKELDSLADKMMATEDYKKQLEIATELEKRHLAEVAIYIPVSNGPNYQACKKGLANYGPRLFATSAYDPDVWINAGWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXV9</accession>
    <name>A0A2Z5QXV9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_04055</name>
        <name evidence="1" type="ORF">RA11412_0998</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87297">
        <property type="protein sequence ID" value="BAV87297"/>
        <property type="gene ID" value="RA11412_0998"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0998"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="134" mass="14106" checksum="46FEDFF3151F6A29" modified="2018-10-10" version="1">MGKLSNTALRLTAGALILDAGVKKLGADENAYAFLQQMAASGVPAVAKLEPKTFGKLISYSETALGATLLTPFIPSRLAGAGLTAFSANLMTMYFRNPDMHDKAFRPTQDGQQLANNIVMLGAGLALLFSGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXZ2</accession>
    <name>A0A2Z5QXZ2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87180">
        <property type="protein sequence ID" value="BAV87180"/>
        <property type="gene ID" value="RA11412_0881"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0881"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="75"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="129" mass="14774" checksum="CE0A1B2FECDC14C7" modified="2018-10-10" version="1">MAGAPDFTPPVVSPFKDVDPSHPFYREITWLASKGITRGWGDGTFRPHEPVSREAMAAFFYRYANSPQFNAPQQSPFRDVRPSDPFYREITWLASKGITRGWGDGTFRPVEPIHRDAMAAFVYRFRGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXZ6</accession>
    <name>A0A2Z5QXZ6_9MICC</name>
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        <submittedName>
            <fullName evidence="3">Cell division protein DivIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87335">
        <property type="protein sequence ID" value="BAV87335"/>
        <property type="gene ID" value="RA11412_1036"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1036"/>
    <dbReference type="Proteomes" id="UP000250241">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="255" mass="28365" checksum="6B234E374C5F9CC5" modified="2018-10-10" version="1">MSERDRQKDSAASASRGTRRPAGARQHAAKNRPSRSAHTPGTPKNRGLRKRTKSSQAKGAGTSRNKQEQQDTQRSPSTVGTLTSAVIGAGRSPRRGKESPQLARQRRMIREGSSDQDPDELTPIAARGFSGQFLVGAIIVVALLVGTYPTLNNYFTQLREIESTREHISQLQRENAQLKVEKTWWDDENYVRQQARSRLFYVNEGDTPYAVTGIDSNNTQVDDTSASAKNAPDDSWTNKMWNSVENPQGAQKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY24</accession>
    <name>A0A2Z5QY24_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_03770</name>
        <name evidence="1" type="ORF">RA11412_1068</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87367">
        <property type="protein sequence ID" value="BAV87367"/>
        <property type="gene ID" value="RA11412_1068"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1068"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="157" mass="17721" checksum="49007B1DBE03461B" modified="2018-10-10" version="1">MLDSSGYSHRYAVSDYELNEIKALYQKFGIAINDRVVELMGVVGDRVLEYRNGSIPARGDVPYEISFCLRDVLGKSAKTNILNTRAHISWYEERLHVSGLVPVAIMPSGPMTFYLNDQENIYGILDDLVLGYQGRSLWNSVVKLFDGHDTHVPISRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY25</accession>
    <name>A0A2Z5QY25_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_0835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87134">
        <property type="protein sequence ID" value="BAV87134"/>
        <property type="gene ID" value="RA11412_0835"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0835"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="722"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="754"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="816"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="860" mass="92238" checksum="6BB47B2FBCA9E970" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYE7</accession>
    <name>A0A2Z5QYE7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87488">
        <property type="protein sequence ID" value="BAV87488"/>
        <property type="gene ID" value="RA11412_1189"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1189"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="67" mass="7391" checksum="CE1EA3F1D123A24C" modified="2018-10-10" version="1">MVLLADILKTLMEQEIIAKQPVEPLSHLLSGAMNEAALWLAETDSPDALEDTMKTLTRLLESLRISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYF1</accession>
    <name>A0A2Z5QYF1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-acetylhomoserine sulfhydrylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87495">
        <property type="protein sequence ID" value="BAV87495"/>
        <property type="gene ID" value="RA11412_1196"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1196"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="68" mass="7237" checksum="6E4C6583AD79A55F" modified="2018-10-10" version="1">MSNNTVPTPANPAGWKFETRQIHAGQAPDAATGARALPIYQTTSFVLRTRSRPLTVLLSPSSGLFTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYI2</accession>
    <name>A0A2Z5QYI2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="2">N5-CAIR mutase</shortName>
            <ecNumber evidence="2">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">purE</name>
        <name evidence="6" type="ORF">I6I94_03760</name>
        <name evidence="5" type="ORF">RA11412_1071</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87370">
        <property type="protein sequence ID" value="BAV87370"/>
        <property type="gene ID" value="RA11412_1071"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1071"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="4">
        <location>
            <begin position="11"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="210" mass="22104" checksum="98EBEC9B5964F385" modified="2018-10-10" version="1">MTTSPYDSDSPVVGIVMGSDSDWSVMEAAATVLEEFGIPYEADVVSAHRMPEDMIAYGQQAHTRGIRVIIAGAGGAAHLPGMLASVTALPVIGVPVRLKNLEGMDSLLSIAQMPAGVPVATVSIDGARNAGLLALRILGCGTDDFAQQVHSDLLDFSKNLRQSAVDKGAALRAKLEERRAEQQDDASTIRSSEPTQPKQPTPGEPQAYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYI3</accession>
    <name>A0A2Z5QYI3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_03625</name>
        <name evidence="3" type="ORF">NCTC10207_00546</name>
        <name evidence="1" type="ORF">RA11412_1107</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87406">
        <property type="protein sequence ID" value="BAV87406"/>
        <property type="gene ID" value="RA11412_1107"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1107"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI22469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="359" mass="39817" checksum="5E5E2D16619E5ABE" modified="2018-10-10" version="1">MGLNYPLDIDAWAAWQKKQNALRWAKTEAAGFFRRNRGNTQQGPASGRLYVRGSVPRVLIVLDSFSPTSCSALLEPLKYLSIIGLAIWCPNTNGTPAALAEYLTDEWEERSLSATELTKTLPGVRIVLSLGHYLQLGRAAYQYAHTVGAEYWVVQHGLLVPAAPPLPVGCTLLAFSDADAEFWMSGRRDVRAFTVGSQLLYNANQKSLGVPVESSGAPIFLGQMHGAELPRSSYVNVSYRFIKKHNAIYRPHPSETDKLSTLTHALWERQGIPIDRSGVPLNELPNPVVSIFSTGVLEAAIRGIPAWVYHPNPPGWLEEFWNRYGMGRWGEDRTPAPPQPDIEPARRIAELIIEHSLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYL0</accession>
    <name>A0A2Z5QYL0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uracil-DNA glycosylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03050</name>
        <name evidence="2" type="ORF">RA11412_1256</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87555">
        <property type="protein sequence ID" value="BAV87555"/>
        <property type="gene ID" value="RA11412_1256"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1256"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="31"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="197" mass="22468" checksum="DE55E3007E63F0CA" modified="2018-10-10" version="1">MNLLPEANLLYQEINDATTNAEMRAKGYTPVYTATAAARIMLVGQAPGRIAQQTHKPWNDASGRLLRQWLGVTDNEFYNPDLFALTPMDFYYPGKGKHGDKPPRKEFAPTWHPRLRELMPQVRLTILVGSYAQRYYLGTGAKKNLAETVADYEQYLPAQLPLVHPSPLTIGWRKRNLWFEDEVIPAAKELVRSIIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYN2</accession>
    <name>A0A2Z5QYN2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87463">
        <property type="protein sequence ID" value="BAV87463"/>
        <property type="gene ID" value="RA11412_1164"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1164"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="PTHR36840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="369" mass="39956" checksum="256FABE25D7B28E8" modified="2018-10-10" version="1">MELFSDLVFATAILFAGSQIHHVLGQGNFGHGAVSYLLVMFFIWWTWVNFAWLSSSFEVDDWLYRSLAAIQMLGVLVVAGGVEQTFGGTVNVALIGYITIRAAQIGQWARASRCGGPAGRAALIYAVGIAVLAVLWVVCALWVPFLALPLVVGELAVPIIAERIGHTPWHAPHITERYGLLTLIVLGGSLRAAAIAVSRALGDHVPALFGVAVLSVLVAGGMWWIYFWAPHRDVINPKRYLSPLKYGYLHYFIFTAAGAFAAAVEVIIDLLAHDNYLMEHQAGLTLSIPVGVFVVAAWLAVLREHAPLPVSISLPVAGVLIVLEGFLPFPFIFIALTVVMLVTLLVLYQPVPSRATEDHKSVEDTADVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYP5</accession>
    <name>A0A2Z5QYP5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Possible conserved membrane proitein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_02935</name>
        <name evidence="4" type="ORF">RA11412_1289</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037233172.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87588">
        <property type="protein sequence ID" value="BAV87588"/>
        <property type="gene ID" value="RA11412_1289"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1289"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="132"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="184" mass="19967" checksum="6769AE1D75FD8877" modified="2018-10-10" version="1">MDTQASPAIPSGLTVIHPARRKSSAAVRRLARERQQAERARSTHRGGSAENPAQQISVTQSPRDTRVPQQQSGGRIFSPIKYIHSRLGRRGMLLLGLPLLTLAALIVLGAITLLAPQGAQAGTSQQTTAVTKVVTVKAEQTLWDIAHEADPETDPRDTIVRIIKLNDLQNTKLQAGQRLEVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYQ6</accession>
    <name>A0A2Z5QYQ6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protease II</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">S9 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_03345</name>
        <name evidence="3" type="ORF">RA11412_1187</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87486">
        <property type="protein sequence ID" value="BAV87486"/>
        <property type="gene ID" value="RA11412_1187"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1187"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="513"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="733" mass="83246" checksum="3407C5E935DEDDD5" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYS6</accession>
    <name>A0A2Z5QYS6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetoacetyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87618">
        <property type="protein sequence ID" value="BAV87618"/>
        <property type="gene ID" value="RA11412_1319"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1319"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="87"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="178" mass="19803" checksum="E73BEAD6B09FB5BF" modified="2018-10-10" version="1">MLPGVRIQVRKQDGTPAPTGEAGQLWISGENVMAGYWENPEATEQAFDGSWFASGDIASIDADNNIYILDRIKDMVLRNGYSVYPREIEDVLYAHPQVRTAAVVGVPDERVGEEILAVILPREATNTSHLEHELDSLARTHLAAYKHPRRYLFVNELPLGPTGKILKRELRAALGLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYS9</accession>
    <name>A0A2Z5QYS9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_1142</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87441">
        <property type="protein sequence ID" value="BAV87441"/>
        <property type="gene ID" value="RA11412_1142"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1142"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="750"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="9">
        <location>
            <begin position="344"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="8">
        <location>
            <begin position="530"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="701"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="946" mass="101176" checksum="D33373A1B4DCC83A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYT3</accession>
    <name>A0A2Z5QYT3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylalanyl-tRNA synthetase beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87612">
        <property type="protein sequence ID" value="BAV87612"/>
        <property type="gene ID" value="RA11412_1313"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1313"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FDX-ACB" evidence="1">
        <location>
            <begin position="230"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="324" mass="34645" checksum="3858ED163237097A" modified="2018-10-10" version="1">MDALAASGMTEVFAYPFVSADENARWVAPVAGEQVASVRLVNPISSAQGWMRRSLLPGLVGVLKRNLSRGFKNLAIFEAGRVFIPRPQHGSALKPPLGQRPSDEVLAELNAGIPEQPIHMGGLFTGAEHDPMPGTQARPYDWRDALDAVRLIADAVGVELVIVQGTHQAFHPGRTARLCTVEGETVGFAGELHPKLLQTENLPERTCAFELDFTALLDVKAPAPQAAPIYGFPAATQDVALLVDASVPVAEVSRALREGAGELLEDIRVFDDYRGAGIEPGKKSLAFALRFRAPDRTLTAEEASASREAAVAVATERFGAVARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYT9</accession>
    <name>A0A2Z5QYT9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87523">
        <property type="protein sequence ID" value="BAV87523"/>
        <property type="gene ID" value="RA11412_1224"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1224"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXPR_C" evidence="1">
        <location>
            <begin position="14"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="143" mass="15434" checksum="4F3CB659E4A588DB" modified="2018-10-10" version="1">MVQFVDGATIAQASPPTMLLPIALGLTWPHRIPQVAAPCDWTQAQTWTFEPLDATAFPAVQMIKEAGKRGGTFPTVFNAANEEAVSAFHAGKIRFTDIVDSVARVLEAHTASGEAVTDTEMTLDAVLNAETWARTQARELLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYV3</accession>
    <name>A0A2Z5QYV3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperone protein DnaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87655">
        <property type="protein sequence ID" value="BAV87655"/>
        <property type="gene ID" value="RA11412_1356"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1356"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="349" mass="38332" checksum="C325525B6088B401" modified="2018-10-10" version="1">MLVYDLGGGTFDVTILRIAGAEFEVVATDGDRNLGGFDFDNALMNYLNDELKKQGAPDSFEDVSLMVQLREQAEDVKKSLSTVPATNAYVTIHGRSYRVPVNRGIFDAQIAGLLRRTEEILEDVLQEAQLTWAHIDKVLLVGGSTRMPAVRQMLEKVTGKTPELGVNPDEAVALGAAIQAALESEPEEETIGFIGGRTAVEGLLGGPVRVKDVTSQALGAIVFEHNTDEKINIIIIPRNSEVPAKHSRKVCTRYDYQESILVTVTQGDDEDPEFVTIVGKGVLDMPIKYPKGAPLEYIYKYDVDQIINVEVIDLTANISLGTFQIDRVANLTQEQVEKANYKIGSMMIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYW3</accession>
    <name>A0A2Z5QYW3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-glucose 4,6-dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87424">
        <property type="protein sequence ID" value="BAV87424"/>
        <property type="gene ID" value="RA11412_1125"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1125"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="199" mass="21776" checksum="EF7E672EB84A451B" modified="2018-10-10" version="1">MAHILVTGGAGFIGSNFVHHLLERTQHTVTVLDKMTYAANAASLAGLDESRFKLVVGDIADRELTDELVAQADAVIHYAAESHNDNSLANPEPFIHTNLIGTFTLLEAVRKHGTRYHHISTDEVFGDLALDDPAKFTETTPYNPPPRTPPPRQAPICWCAPGCVLSGLRRPSRTARITTDRISTSKNLFPGRLRISSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYX5</accession>
    <name>A0A2Z5QYX5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87668">
        <property type="protein sequence ID" value="BAV87668"/>
        <property type="gene ID" value="RA11412_1369"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1369"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="49" mass="5919" checksum="325133B5EBD11048" modified="2018-10-10" version="1">MPFLPKILGKFYDFLQRKYFIKRWEKEYQLAPSAPEYEAGVEANTPFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ04</accession>
    <name>A0A2Z5QZ04_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinG family ATP-dependent helicase YoaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87586">
        <property type="protein sequence ID" value="BAV87586"/>
        <property type="gene ID" value="RA11412_1287"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1287"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HELICc2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="107" mass="11712" checksum="C97A7721FD0A0D48" modified="2018-10-10" version="1">MVVMDRIPFPRPNDPLVQARTEAVQANRGNGFMAVSAYHAAIRMAQGAGRLIRSVTDRGVVAVLDSRLATQSYGGYIMRSMPPLWATQKREVVLGALTRLSQSIRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ14</accession>
    <name>A0A2Z5QZ14_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="5">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="5">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">truB</name>
        <name evidence="10" type="ORF">I6I94_03125</name>
        <name evidence="9" type="ORF">RA11412_1241</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87540">
        <property type="protein sequence ID" value="BAV87540"/>
        <property type="gene ID" value="RA11412_1241"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1241"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015225">
        <property type="entry name" value="tRNA_psdUridine_synth_fam2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09142">
        <property type="entry name" value="TruB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="6">
        <location>
            <begin position="31"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="8">
        <location>
            <begin position="222"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C" evidence="7">
        <location>
            <begin position="287"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="382" mass="40266" checksum="C66673D243690F6B" modified="2018-10-10" version="1">MAKTKGDGPSGLVVIDKPEGITSHDVVSKLRWIAGTRRVGHAGTLDPAATGVLILGLNKATKLLTYLVGQDKTYQATIQLGISTETDDAQGRQTGTCPEAVEALTEQRILEAVASLTGDIMQVPSAVSAIKVNGVRSYTRVRSGEQVELAARPVRVNEFTVHSIQRTMTSWCVLVSQQELAEAGIDAAGTHGELSDPTTAITSVPVINCEVTVSCSSGTYIRALARDLGQMLGTGGHLIRLRRTRVGGTTLADAAALPELLERREAAGQPLTDMPLLSLEEAARRLFKVRELSAQQATDVSFGRRISPNGDGTVTLRQAHASTGDGGEKQHATTEGVYAAFAPDGTLVALLENLKQRGSVVAAPTLVFEAGTDFSGTLEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ74</accession>
    <name>A0A2Z5QZ74_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87663">
        <property type="protein sequence ID" value="BAV87663"/>
        <property type="gene ID" value="RA11412_1364"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1364"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4" evidence="3">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="61"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="258" mass="28482" checksum="909DE184AF4C2382" modified="2018-10-10" version="1">MNGRINQAYEAAQLYYVQDMTMDGIANRLGVSRATVSRLLKSARETGMVQIRLDDSFRVRSELERRISERYKTRVSLVNTRADATPIAVMGQVARTAAQLLDSLIDDGTSVGVAWGATVTEVSRHLPRRPLNGVKIVQLNGAGNAHHTGIPYLDTLLGRLVTAYDAYIVHFPVPAFFDYADTKDAMWRERSVQATLRAQRKVDVALFGIGAFGGAIPSHVYSGGYFDAAAQRTLREQGVVGIYVLSCCEKTARGRTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZE1</accession>
    <name>A0A2Z5QZE1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formaldehyde dehydrogenase MscR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87818">
        <property type="protein sequence ID" value="BAV87818"/>
        <property type="gene ID" value="RA11412_1519"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1519"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="27"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="198" mass="20787" checksum="827CF1494BE2B9C0" modified="2018-10-10" version="1">MTAGLGAVLNTGALKRGESVAVIGCGGVGTAAIAGAQLGGATTIIAVDIDDDKLERARQQGATHTVNSAKVDPIEAIRELTGGFGADLVIDAVGIAPTFKQAFEARDLAGRVVLVGVPEPGTTWDIPLDEVFGRGGSIKSAWYGDTLPSRDFPEFVDQYLLGRLDLDGFVSERIKLEDVNDAFETMKTGRVLRSVVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZG2</accession>
    <name>A0A2Z5QZG2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-isopropylmalate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87848">
        <property type="protein sequence ID" value="BAV87848"/>
        <property type="gene ID" value="RA11412_1549"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1549"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="2">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="232" mass="24874" checksum="84940ABA32F38D68" modified="2018-10-10" version="1">MSPLSSPGEIDFVVVREGTEGPYAGNGGTLREGTQEQIATEVSLNTAHGVSRLIRYAFELAQARRKKLTLIHKTNVLVHAGRLYTRLFEEIGREFPDVQTDYLHIDAATIFMTTNPSRFDVIVTDNLFGDILTDQAGAVTGGIGYAASGNINAVGKFPSMFEPVHGSAPDIAGQNKANPTATILAAALLLRHLGYESTAVRIEEAVEADMRANGARTRTTVEVGDDVLGFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZJ5</accession>
    <name>A0A2Z5QZJ5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87892">
        <property type="protein sequence ID" value="BAV87892"/>
        <property type="gene ID" value="RA11412_1593"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1593"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="60" mass="5892" checksum="2DEE16FBA7A2B29C" modified="2018-10-10" version="1">MTVANGNHPGGDSAPQGTRGSTSRSLANTGANGVIMLAGMGALAIVTGAVVLVVRRRSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZJ6</accession>
    <name>A0A2Z5QZJ6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Type I-E CRISPR-associated protein Cse1/CasA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">casA</name>
        <name evidence="3" type="ORF">I6I94_01830</name>
        <name evidence="1" type="ORF">RA11412_1558</name>
        <name evidence="2" type="ORF">RA11412_1568</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888655.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87857">
        <property type="protein sequence ID" value="BAV87857"/>
        <property type="gene ID" value="RA11412_1558"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87867">
        <property type="protein sequence ID" value="BAV87867"/>
        <property type="gene ID" value="RA11412_1568"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1558"/>
    <dbReference type="KEGG" id="raj:RA11412_1568"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013381">
        <property type="entry name" value="CRISPR-assoc_prot_Cse1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09481">
        <property type="entry name" value="CRISPR_Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02547">
        <property type="entry name" value="casA_cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="571" mass="64088" checksum="EE724E25DCB8EE82" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZM5</accession>
    <name>A0A2Z5QZM5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87897">
        <property type="protein sequence ID" value="BAV87897"/>
        <property type="gene ID" value="RA11412_1598"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1598"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4759" checksum="19DF65076A48E06A" modified="2018-10-10" version="1">MTPYTCPMGHIIGVQTGEWDTEEKMLNPQTPQKTRRTITMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZT1</accession>
    <name>A0A2Z5QZT1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit b</fullName>
            <shortName evidence="13">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpF</name>
        <name evidence="16" type="ORF">RA11412_1471</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="11 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87770">
        <property type="protein sequence ID" value="BAV87770"/>
        <property type="gene ID" value="RA11412_1471"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1471"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0138">CF(0)</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="39"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAV87770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="160" mass="17317" checksum="997487AB53D9B70A" modified="2018-10-10" version="1">MTAIGFLILLFIVIKYIAPAFEKIYQDRKEAIEGGLAKAKKVQAEAAAAREEYSQQLDSARLEAQQIREEARAEGEAIIAKARERATAEAQRITENAQKTIEAERAAAAVSLRSEVGSLATALAGKIVGEALTDDARSARVVDRFLADLETEQQNAGATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZV6</accession>
    <name>A0A2Z5QZV6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_01775</name>
        <name evidence="3" type="ORF">RA11412_1597</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87896">
        <property type="protein sequence ID" value="BAV87896"/>
        <property type="gene ID" value="RA11412_1597"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1597"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033777413" evidence="1">
        <location>
            <begin position="38"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="470"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="592" mass="64519" checksum="8078913EADD761D7" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R029</accession>
    <name>A0A2Z5R029_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_01030</name>
        <name evidence="1" type="ORF">RA11412_1768</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88067">
        <property type="protein sequence ID" value="BAV88067"/>
        <property type="gene ID" value="RA11412_1768"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1768"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="333" mass="36353" checksum="9DDB0268306FFBBF" modified="2018-10-10" version="1">MSETTIDELIPGAWSIATSEPDLLRSRRSEHFAAEVHERTSLTFGEQYRDAVAPNLEYEAPKDPQAWANRVIELPTDTGVNEYQALTGIRYRGQNLERPFVDVVATNIPCDAHSITRLTRLVLSEYAQFRPVCARFFVPGSTDHLLSELRKTTGAQGSAFDMHLVSGELKMLLERPAPKNVARVQLAPISSGEAAALCTRIYADIAEVKPDLPEWATPQDAQSLADAASDGLLRQVLVDETQAGVLAFAARGEQGVHGYSVEEICLDAPFLGQKLANTVLWHGMNSISHSTAINQGSALWGTIHPHNAPSLRNALGVGRTIVGSYVWVGERAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R059</accession>
    <name>A0A2Z5R059_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_01850</name>
        <name evidence="2" type="ORF">RA11412_1555</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87854">
        <property type="protein sequence ID" value="BAV87854"/>
        <property type="gene ID" value="RA11412_1555"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1555"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT90181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="94" mass="10441" checksum="66B0AC802470705E" modified="2018-10-10" version="1">MLEIFSSKKRVWRAVRKGTVMAFANASIIMLIATVADALRSVWTIVAIMVASLLAYFAAYQEARFDDEQDAWEAQQKAHAEAADTSSTELEKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0A8</accession>
    <name>A0A2Z5R0A8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oligoribonuclease</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">orn</name>
        <name evidence="3" type="ORF">I6I94_01735</name>
        <name evidence="2" type="ORF">RA11412_1605</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037237428.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87904">
        <property type="protein sequence ID" value="BAV87904"/>
        <property type="gene ID" value="RA11412_1605"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1605"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="PTHR11046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="7"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="212" mass="23272" checksum="6EA807A164E20462" modified="2018-10-10" version="1">MSISSERIVWIDCEMTGLDVANDALIEVGVLVTDSDLNVLGQGVELVIKPGPEAPAGALENMNSYVRTMHESSGLLADIEHGVSMDHAQEAVLKYVKKYVPVAGKAQLGGNSVGMDKRFLERYMPELMAHLHYRVIDVSTIKELAARWFPAARYSAPAKTGNHRALGDIVDSIDELKYYRRTIFVQDGPDATTAARIASDIERERAELNASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0H7</accession>
    <name>A0A2Z5R0H7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_00225</name>
        <name evidence="3" type="ORF">RA11412_1976</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88275">
        <property type="protein sequence ID" value="BAV88275"/>
        <property type="gene ID" value="RA11412_1976"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1976"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033777414" evidence="2">
        <location>
            <begin position="37"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="175" mass="18467" checksum="48CE777502C71CB2" modified="2018-10-10" version="1">MLKTRPSSARRTALLGVSAVVLALGSSALAVPGASAATPSASPSSQVPSQDGTSSTSNNSPVVSGEAKHDENFKFMQDERIANWIEYRVTGEHEITFTVITGTPSCYDVRAEVVEKNGTLKVALVEGTILGAPDGCTEEALYKDVKVKTKAKASTLKVQQLPKSQVHLNKKITPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0J1</accession>
    <name>A0A2Z5R0J1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bifunctional glycosyltransferase family 2/GtrA family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Dolichyl-phosphate mannose synthase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I6I94_07840</name>
        <name evidence="9" type="ORF">RA11412_0080</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86379">
        <property type="protein sequence ID" value="BAV86379"/>
        <property type="gene ID" value="RA11412_0080"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0080"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="7">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="8">
        <location>
            <begin position="234"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT88443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="382" mass="41105" checksum="4114DFE295877F39" modified="2018-10-10" version="1">MIVLIPAYKPDNSLTRLTHQLTAHSENIQVLVIDDGSGSEYTPIFTELTLTGATVITHPINLGKGAAIRTGLNWARIYQPRQVVVTADADGQHLVRDILRVGAHTATHADSGKHSLVLGVRTLPDNTAQGSGTVPARSKVGNALTIGFFTLATGTRLADTQTGLRGFTPQMIEWALNIPGDKYEYEFTMLLRATRAGINLVQVPIVKVYEPGNPTSHFRPVRDSALIYAPLIGFLASSFAGFLIDAAALFTLVALGTPLLVAVIAARIISALANFSVNRLMMRDGAARPSPGNSLMRYATLAVGILAANAALLEALMTLGVHLVAAKVLTEAVLIPVSFAVQRRWVFLPTRTPQREEHTAPELQLSKLSGASVEEEYTGRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0J2</accession>
    <name>A0A2Z5R0J2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heme O synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88050">
        <property type="protein sequence ID" value="BAV88050"/>
        <property type="gene ID" value="RA11412_1751"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1751"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="96" mass="10280" checksum="60B682F0A275CE99" modified="2018-10-10" version="1">MKGHTIQQARACAPAAPAGDTVEGPVGLRRKIKAYIHLTKPQVIELLLVTTAPTMMFAAHGMPSFWLMMNTLIGGAMAAGRRGRLTVILTAILTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0J8</accession>
    <name>A0A2Z5R0J8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoate--protein ligase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Lipoate-protein ligase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00280</name>
        <name evidence="2" type="ORF">RA11412_1958</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88257">
        <property type="protein sequence ID" value="BAV88257"/>
        <property type="gene ID" value="RA11412_1958"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1958"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="31"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="232" mass="25084" checksum="B635E64E5D2C38EA" modified="2018-10-10" version="1">MDILRETGETAGGIIARYDETLTILREVAHRRRNATLRIYQPEATVAFGRRDELNPGFAQAVTACKNMGFNVLVRKVGGHAAAYHPGCLVIDHFQPADDAKTGSNLRYKLFGELFARALQDVGVDAAVGEIPGEYCPGEFSVHARLGGERSGERIKLVGTAQRVVSGAWWFSTGIVVTDSAPLRSVTERVYAALGLPLDPATIGAAQEANPALLMEDLEDAILDVYAQNGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0L8</accession>
    <name>A0A2Z5R0L8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2087 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00210</name>
        <name evidence="2" type="ORF">RA11412_1979</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037233657.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88278">
        <property type="protein sequence ID" value="BAV88278"/>
        <property type="gene ID" value="RA11412_1979"/>
    </dbReference>
    <dbReference type="GeneID" id="32322644"/>
    <dbReference type="KEGG" id="raj:RA11412_1979"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018656">
        <property type="entry name" value="DUF2087"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09860">
        <property type="entry name" value="DUF2087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2087" evidence="1">
        <location>
            <begin position="90"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="161" mass="18504" checksum="E6FF6C690BFAC19B" modified="2018-10-10" version="1">MQQNLTPIIAALANSDCQRMYAQIVLGQAPESPNRRERKLIDRLKTVGLVTEDPAGSLILTDVFTEYLLAGKHERGQETVGVQRFLVKGRVQRWPSRAEDKDALLRWIITESIAESERLAESELNDRIRRYTEDPALVRRYGVDFGMLRRDPATQIYYLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0U5</accession>
    <name>A0A2Z5R0U5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88358">
        <property type="protein sequence ID" value="BAV88358"/>
        <property type="gene ID" value="RA11412_2059"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2059"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="190" mass="21303" checksum="AB4B1C1BA5DE535D" modified="2018-10-10" version="1">MAHGRTGGVVWAKENMFQRAHALSIPAVPWGFTCPDHTVAHIQEAMRQARERGRRLRMLMIYRAPDLPITPAPATHEGNPPNDLPALEPSPLRDAWCEAGFTAQRHGGLHDRMLALANVRELDEPEPIDLARYENTSTFRPLSHSMRGSLSRALGKKYTPAQDPGAPSKIYWVQGHAEVQDILSFRRFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0W5</accession>
    <name>A0A2Z5R0W5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">tatC</name>
        <name evidence="8" type="synonym">tatC2</name>
        <name evidence="7" type="ORF">I6I94_00775</name>
        <name evidence="8" type="ORF">NCTC10207_01152</name>
        <name evidence="6" type="ORF">RA11412_1832</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887189.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88131">
        <property type="protein sequence ID" value="BAV88131"/>
        <property type="gene ID" value="RA11412_1832"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1832"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI23055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="294" mass="33037" checksum="D3904E1BA85F529F" modified="2018-10-10" version="1">MAKPDQDVRSRKSNPEARMELKEHLREFRDRLIKAAIATLIAAILSVIFLYQPFINAISQPLIEINEQQGRHATLNYSTIASPFDQLMRVGMYIGLVLASPVWLYQGLRYLLPALHAKEKKYLFGFLSGSLFAFACGVAISWWTLPGVVRALTMFTPSRAENIIAANDYIAFVVKFMFFFSLAFVIPVILVGINMLGLIRGKTVLKSWRWVVVLVAVIAAMTAPGTDIMMMFYLMAPLLAFFFIAIGICLINDKRRDRREAKLAKGMTEESIKTATSAEDLAAMGHFEKDEAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Z5</accession>
    <name>A0A2Z5R0Z5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="7">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">RA11412_2043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88342">
        <property type="protein sequence ID" value="BAV88342"/>
        <property type="gene ID" value="RA11412_2043"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2043"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="174" mass="18828" checksum="E0094316C81314EB" modified="2018-10-10" version="1">MDDASADDIMAQLLVLEAQDPDRDITLYINSPGGSFTAMTAIYDTMQYIRPEIQTVCLGQAASAAAVLLAAGTPGKRLALPNARVLIHQPALSGQQGGQASDLEIHANEVMRMREWTAKTLALHAGKTYEDVDRSIERDNILTASAALEYGLIDKVLDSRKLNKPAINTPESYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R122</accession>
    <name>A0A2Z5R122_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Replication-associated recombination protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_00505</name>
        <name evidence="4" type="ORF">RA11412_1897</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88196">
        <property type="protein sequence ID" value="BAV88196"/>
        <property type="gene ID" value="RA11412_1897"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1897"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="71"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="484" mass="51586" checksum="AB4F12AC5116B97A" modified="2018-10-10" version="1">MADSLFDLGLPDDEDRVKFIAPTPASARSSAPLAVRMRPQNVDEVLGQAHLLNPGSPLRVLAGADHAGPAGPASVILYGPPGTGKTTLAHVIARAPGRKFVELSAITAGVKDVRAVMDQALLDRDMYGTTTVLFLDEIHRFTKAQQDALLPGVENRWVILVAATTENPSFSVISPLLSRSLLLRVHSLEPADIESLINRALEDPRGFNGAAVIDEDARAHLAAVSGGDARRSLTSLEAAAAIAFSENEQAESPDENTDPGGETTPSKPVRITLAHAQEAVDRAAVRYDKDGDQHYDVISAFIKSIRGSDADAAVHYLARMLEGGEDPRFVARRIMIAASEDIGLADPQALQVATAAAQSVALVGMPEARIILSQAVIYCALAPKSNAAYVAINKAIADVRAGLSGQVPVHLRDAHYAAAADLGHGDGYIYAHDEPGHVAAQQYMPDTLRGKVYYEPTPHGFERTLTERRERIREILDRANGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R148</accession>
    <name>A0A2Z5R148_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Holliday junction DNA helicase RuvB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88211">
        <property type="protein sequence ID" value="BAV88211"/>
        <property type="gene ID" value="RA11412_1912"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1912"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuvB_N" evidence="3">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="74" mass="7784" checksum="7ADFF4B15F8FA693" modified="2018-10-10" version="1">MLEASKMRGRSADHVLLSGPPGLGKTTLAMIIAAEMDAPLRITSGPAIQHSGDLAAILSSLTPARCFSWMKYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R178</accession>
    <name>A0A2Z5R178_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical radical SAM family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88251">
        <property type="protein sequence ID" value="BAV88251"/>
        <property type="gene ID" value="RA11412_1952"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1952"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="193" mass="20843" checksum="8322C0FDDE717364" modified="2018-10-10" version="1">MAPAQPSGAPAPHDGRIPASSARGCESRDFSLYVHIPFCSVRCGYCDFNTYATEDFGDGIGLGTYADDAIAEILFAARTLEASGVARRPLHTVFFGGGTPTKLPARDLVRILQAAADVFGIRTGAEITTEANPDSVTRDDLFALKEGGFTRVSFGMQSVVPEVLQVLDRTHTPRMFPKLLRGHKKLACRSRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R188</accession>
    <name>A0A2Z5R188_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_00220</name>
        <name evidence="3" type="ORF">RA11412_1977</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88276">
        <property type="protein sequence ID" value="BAV88276"/>
        <property type="gene ID" value="RA11412_1977"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1977"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340114" evidence="2">
        <location>
            <begin position="39"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="188" mass="19420" checksum="542C07CB23BECE3C" modified="2018-10-10" version="1">MLMLRTRPSSARRAALLGVSTVVLALGSSALAVPGASAVDSSASSSSSASASASADASSSASSSVPSKDNGSPNEGAEAKHDENFKFLEYENIIDWTDYKVTGEHEITFTTLTGTPRCYDVRAEVVEKDGVMNVALVEGTIPGAPDACTAEARIAKAKVKTKAKASTLKVQQLPESMVRLNKGAIQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1A2</accession>
    <name>A0A2Z5R1A2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal RNA small subunit methyltransferase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_2153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88452">
        <property type="protein sequence ID" value="BAV88452"/>
        <property type="gene ID" value="RA11412_2153"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2153"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="248"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="350"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="479" mass="51663" checksum="7EBA7BA58A0D7665" modified="2018-10-10" version="1">MSEQHNNDGQHPPRRPAAKGTARGGRFDGRTSEQRRTSRTKPTGGGQKRGGGGATERNRKGHERNRRSLSQRSFSASAPSQRSRTADPARLVAFEVLRAVAESDAYANLVLPKTIRAYRLDHRDAGLATELTYGTLRNQGTYDAVLARCADRPLHKIGTTTLIILRMGAHQLLKMRVPAHAALNQSVSLARERIGSGPSGFINAVLRRVSERTADEWFELIEAESKDETERMGFATSHPAWIVRAMRQALAAHGRDPQEIRALLEANNVSPVVNLVALPGVGDLREAEENGAVPGELVEGSALYSAGDLARLESVREGTVRAQDVGSQLVARALTAVPIEGSDRAWLDMCAGPGGKAALLGALGAQRGAHLVANESAPHRAKLVEQSMRPLPEETYTVLTGDGRSITATLAREAAKLPDSIGPDTLFDRVMVDAPCSGLGALRRRPEARWRKTPRDIADLLPLQGQLLDAAIEVTRPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1D2</accession>
    <name>A0A2Z5R1D2_9MICC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88463">
        <property type="protein sequence ID" value="BAV88463"/>
        <property type="gene ID" value="RA11412_2164"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="57" mass="5530" checksum="82B2D70297A6062D" modified="2018-10-10" version="1">MVVRGSGALSPSRLTAAASIIIAASLGVGLRTASAIGAYLSGASSREGVFFGSCASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1R0</accession>
    <name>A0A2Z5R1R0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I6I94_10230</name>
        <name evidence="10" type="ORF">RA11412_2303</name>
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    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Micrococcales</taxon>
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    <reference evidence="10 12" key="1">
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88602">
        <property type="protein sequence ID" value="BAV88602"/>
        <property type="gene ID" value="RA11412_2303"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2303"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="258"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="325"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT88881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="591" mass="65434" checksum="F1E1567F42386E16" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1V6</accession>
    <name>A0A2Z5R1V6_9MICC</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88725">
        <property type="protein sequence ID" value="BAV88725"/>
        <property type="gene ID" value="RA11412_2426"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2426"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="44" mass="4930" checksum="C0D8D8AA9E11A963" modified="2018-10-10" version="1">MTLPTTMRAVQYTEYGASNVLTINQVPVPTPARAKCWCVFRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Z0</accession>
    <name>A0A2Z5R1Z0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_09540</name>
        <name evidence="7" type="ORF">NCTC10207_01685</name>
        <name evidence="5" type="ORF">RA11412_2466</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88765">
        <property type="protein sequence ID" value="BAV88765"/>
        <property type="gene ID" value="RA11412_2466"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2466"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VEI23704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="168" mass="18571" checksum="DD1BB42629F3CF3D" modified="2018-10-10" version="1">MALAMETRPAAYAVVIEQGKLLMTRWAPEDRSHEPLWTLPGGGMEPGEQADETALRETLEETGYSVAIEDVLGVHAGHFPARNGMYGNSLPFCALRIIYRAHIVTGQLRAEENGSSDIARWVPISEIDTLRYGTIIDEVASMMGYANAAAWALEYREFLADENARKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Z6</accession>
    <name>A0A2Z5R1Z6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="15" type="ORF">I6I94_10285</name>
        <name evidence="16" type="ORF">NCTC10207_01542</name>
        <name evidence="14" type="ORF">RA11412_2291</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="15 19" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 19">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006889167.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88590">
        <property type="protein sequence ID" value="BAV88590"/>
        <property type="gene ID" value="RA11412_2291"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2291"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="13">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV88590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QQT88892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VEI23434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="82" mass="9142" checksum="718F759F489E10A3" modified="2018-10-10" version="1">MDWRSRAACLDKDPELFFPVGNTGPALLQIEEAKTVCRSCEVVDVCLKWAIDTGQDSGVWGGTSEDERRAMKRRAARARRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R202</accession>
    <name>A0A2Z5R202_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YdeI/OmpD-associated family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_09670</name>
        <name evidence="1" type="ORF">RA11412_2439</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88738">
        <property type="protein sequence ID" value="BAV88738"/>
        <property type="gene ID" value="RA11412_2439"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2439"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="75" mass="8592" checksum="0B7C2554343FAF5C" modified="2018-10-10" version="1">MRERHHMPNDIAAALKSSGLCADYKARPAYQRNNYIGWIDRAKTSGTRIERLEQMLTELAQGGIYMGKEHKASRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R218</accession>
    <name>A0A2Z5R218_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1963 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_10580</name>
        <name evidence="1" type="ORF">RA11412_2222</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88521">
        <property type="protein sequence ID" value="BAV88521"/>
        <property type="gene ID" value="RA11412_2222"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2222"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015315">
        <property type="entry name" value="DUF1963"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035948">
        <property type="entry name" value="YwqG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09234">
        <property type="entry name" value="DUF1963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103032">
        <property type="entry name" value="SSF103032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="292" mass="32797" checksum="773A027C768D0F5A" modified="2018-10-10" version="1">MGKILDQAREVIKRIEENDQSPTVRITATAAAEPLPVTSSKFGGVPYLPAGVDAPANKEGQPLGMIAQINCAELPQNTIYPESGMLQFWIDPGDEEALWGMDDTIADRTQNGYRVIYYPELGEPNPDARAAKANWDDYGWPISPETVEYALSFEAALGDKWSLMNETAEALFVDTWNELYPETPIEDFFDEIDELGEDRVTDTIDRETEDQLTHKIGGEPIFTQNDPRDFADDLRDYTVNLLTMISVSDGNWADPNTPTIMWGDVGTANWLITPEQLKNRDFSQVIFEWSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R255</accession>
    <name>A0A2Z5R255_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_2325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88624">
        <property type="protein sequence ID" value="BAV88624"/>
        <property type="gene ID" value="RA11412_2325"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2325"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="6">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="121" mass="13620" checksum="10F7FE4EB5CD0A30" modified="2018-10-10" version="1">MSPLSMREVVEALAHRIATQDAPVMDGVTLASLHSAKGLEWDAVFLCGLNEGLMPISYAQTSDEVDEERRLLYVGITRARKHLCLSWSLSRTAGGRGNRKRSRFLDDIDPKRRPRRAPYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R270</accession>
    <name>A0A2Z5R270_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Superfamily I DNA and RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_05290</name>
        <name evidence="3" type="ORF">RA11412_0690</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86989">
        <property type="protein sequence ID" value="BAV86989"/>
        <property type="gene ID" value="RA11412_0690"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0690"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_12" evidence="2">
        <location>
            <begin position="694"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT90003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="901" mass="96490" checksum="9A13D27CA4952F8D" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2B0</accession>
    <name>A0A2Z5R2B0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrate reductase subunit beta</fullName>
            <ecNumber evidence="4">1.7.99.4</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Respiratory nitrate reductase beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">narH</name>
        <name evidence="4" type="ORF">I6I94_09005</name>
        <name evidence="3" type="ORF">RA11412_2596</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.7.99.4" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887783.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88895">
        <property type="protein sequence ID" value="BAV88895"/>
        <property type="gene ID" value="RA11412_2596"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2596"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10557">
        <property type="entry name" value="NarH_beta-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029263">
        <property type="entry name" value="Nitr_red_bet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038262">
        <property type="entry name" value="Nitr_red_bet_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006547">
        <property type="entry name" value="NO3_Rdtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14711">
        <property type="entry name" value="Nitr_red_bet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01660">
        <property type="entry name" value="narH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033776646" evidence="1">
        <location>
            <begin position="20"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="537" mass="60642" checksum="A4DA72E7FEFABFEB" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2B9</accession>
    <name>A0A2Z5R2B9_9MICC</name>
    <protein>
        <submittedName>
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        </submittedName>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_08955</name>
        <name evidence="1" type="ORF">RA11412_2606</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88905">
        <property type="protein sequence ID" value="BAV88905"/>
        <property type="gene ID" value="RA11412_2606"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2606"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="88" mass="9200" checksum="A12053AE46B9D282" modified="2018-10-10" version="1">MIVRFYAAACAAAGVDQVNITLSDLVSPTLGALVQELGDRYTGTTASGLTLAQVMQQCSFLLDGVRSEHEAALTEETRVDVLPPFAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2C0</accession>
    <name>A0A2Z5R2C0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87039">
        <property type="protein sequence ID" value="BAV87039"/>
        <property type="gene ID" value="RA11412_0740"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0740"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="133" mass="14520" checksum="762AA4168A7D1D47" modified="2018-10-10" version="1">MFRVVLLAGPALIMAWQAIRLAVPIIAAIPLAYLVGQSWCAWAYHKGRSPKIIMVANYFSIIAALVPMAPVGALLLSPSATQVVLNYLWSSPLLVPLTVVWILIELPIETVFSLFYARRSGRRLSIMAEASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2C6</accession>
    <name>A0A2Z5R2C6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_09600</name>
        <name evidence="5" type="ORF">RA11412_2453</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88752">
        <property type="protein sequence ID" value="BAV88752"/>
        <property type="gene ID" value="RA11412_2453"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2453"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="304" mass="33232" checksum="D0A111D19B0AF009" modified="2018-10-10" version="1">MNTSHVIEAQGLTQIFRTRSGNVTAVDNLDLTIDKGEIVALLGPNGAGKTTLIDMLLGLSTPTRGVLTIDGASPKAAIQSGNIGAVLQTGGLLKDLTVQQTLDMLASLYPTRLDMNQVLADADLTELAHRKVGKCSGGQQQRIRFAIATMHDPNILILDEPTTGMDVTARRTFWERMDKLAETGKTIIFATHYLEEAQNFAQRIVLMDNGKIIADGTSEEIRDLTGGRHVSFLADKPITFSEYPMLSVETSEENGAYRHRTTVANADEFARVLLTKYTVRDLEIVKPSLDESFVQLTDRAAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2D8</accession>
    <name>A0A2Z5R2D8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 14" type="primary">rpsC</name>
        <name evidence="14" type="ORF">I6I94_09125</name>
        <name evidence="15" type="ORF">NCTC10207_01776</name>
        <name evidence="13" type="ORF">RA11412_2564</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="14 18" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887779.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88863">
        <property type="protein sequence ID" value="BAV88863"/>
        <property type="gene ID" value="RA11412_2564"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2564"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="12">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="219"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV88863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT88674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VEI23865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="265" mass="29642" checksum="33799C903132C35D" modified="2018-10-10" version="1">MGQKIHPNGFRLGITTEHVSKWFADSNKPGERYADFVREDVKIRELLAKNLDRAGVAKVEIERTRDRVRVDIHTARPGIVIGRRGAEADRIRAELEKLTGKQIQLNILEVANPDLSAQLVAQGIAEQLASRVAFRRAMKKAIQSAQRAGAKGIRIQCSGRLGGAEMSRSEFYREGRVPLHTLRANIDYGFFEAKTTFGRIGVKVWIYKGDLTDKELAAQQAANNRRGNRRDGDRRRSGGRGPRRERRNENASANTEAKTAENGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2E6</accession>
    <name>A0A2Z5R2E6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88720">
        <property type="protein sequence ID" value="BAV88720"/>
        <property type="gene ID" value="RA11412_2421"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2421"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016248614" evidence="2">
        <location>
            <begin position="32"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="385" mass="41415" checksum="725F8D5B0CDBE0BC" modified="2018-10-10" version="1">MRYFRTRGALAGASALALVGATAVPLSQAFAEPQQAGSTPSSQQSTPSTSEQKPSIQKTEGTLDPLAEKNTIKVQGTGLDKTLTDGYYAEMWEIDAQGQPVGENIAEASDQLTLGQRGQFDTTLTVRGSRVDPQKHYAVFIVDHTGRGGHMGVHATAPVNIKPTDPTKLRPRFETSPETLYTHRQDNEVTIRGKYYYPPNSDASVAISLREKHEDGGPGDEVATGTVVASELKDGTFTYKLHVPGEKIKDKTYYTLAVAMDGGTKEQGAIKELYGHGGSFAVITDGTVSRSSQHNQVKVAGGGFKNVQQGTAMHLRLREYNIDAQKPAGDALAEKQVTVNPPNGSFETDFAVPADKLQAGKKYVIEASIDGQEQSEVTEYITVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2H0</accession>
    <name>A0A2Z5R2H0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg/Co/Ni transporter MgtE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88671">
        <property type="protein sequence ID" value="BAV88671"/>
        <property type="gene ID" value="RA11412_2372"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2372"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MgtE_N" evidence="2">
        <location>
            <begin position="195"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="374" mass="41427" checksum="5548517474857314" modified="2018-10-10" version="1">MSNTKSSAPSKIYIARLLGLDVFDPFGDRLGRLRDVVVLKRGFGAAMAAGSRPTKGNEPVVVGIIIEVLGKKRVFMPMTRVRSIEASQIISTGLVNLRRFEQRNSEVLVVGELFDRRVRLLDGSGDAVIEDVAIEQRRNGDWGITELFVSRTVKSSSGWRRRSKETLVVDWDETILSTDLEPQEATTFVANHENARAADLADAIHEMSDKRMLEIAHELQDERLADVLQELPEEDQVQILSHLDDERAAQVLEEMEPDDAADLLIELPDAQREKLLELMEPDEAEDVRRLLEYDEGTAGSLMNPVPIILSPSRRWRRRWRIFGLRRSPGNGRGGAGGASPAGNPHGQVPGDGAHAAAAAGAAERVDWAHPRHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2L2</accession>
    <name>A0A2Z5R2L2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator transcription factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transcriptional regulatory protein glnR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_08840</name>
        <name evidence="3" type="ORF">RA11412_2634</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023133184.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88933">
        <property type="protein sequence ID" value="BAV88933"/>
        <property type="gene ID" value="RA11412_2634"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2634"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="226" mass="25076" checksum="43B47814F1DB8DBA" modified="2018-10-10" version="1">MYRITLLSDASGEQSDIAALSVLSHRVDLYPLATSAKRFETAHHDVVMIDARRKLIEARNTAQALKTAGLDVPLMMVLTEGGMAAVSSAWMVDDIVLDQVSPSELDARLRLVVTSPESSADTENSAQIIRVGALYIDAPAYSAYLNGVALNLTFKEFELLKFMAQYPGRVFTRAQLLSEVWGYDAYYGGTRTVDVHVRRLRSKLGTEYEQMISTVRNVGYSFNAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2R2</accession>
    <name>A0A2Z5R2R2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89018">
        <property type="protein sequence ID" value="BAV89018"/>
        <property type="gene ID" value="RA11412_2719"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2719"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="92" mass="10154" checksum="4980CC7B0FEE30DB" modified="2018-10-10" version="1">MSPVTFSECIYRGEANFNENQYGERADFSSSTFGKEAVFADSVYSTKTVFSYSVFSAATDFSNIVLAGSSPSFKKCVFAVGKKPARREFKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2T0</accession>
    <name>A0A2Z5R2T0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sodium/proline symporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Proline permease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">putP</name>
        <name evidence="10" type="ORF">I6I94_08555</name>
        <name evidence="9" type="ORF">RA11412_2704</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the sodium-dependent uptake of extracellular L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28967"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89003">
        <property type="protein sequence ID" value="BAV89003"/>
        <property type="gene ID" value="RA11412_2704"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2704"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005298">
        <property type="term" value="F:proline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031402">
        <property type="term" value="F:sodium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015824">
        <property type="term" value="P:proline transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11475">
        <property type="entry name" value="SLC5sbd_PutP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011851">
        <property type="entry name" value="Na/Pro_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02121">
        <property type="entry name" value="Na_Pro_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV89003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT88573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="513" mass="55305" checksum="070DF4F9DB0BFDAA" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2U9</accession>
    <name>A0A2Z5R2U9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">rplV</name>
        <name evidence="13" type="ORF">I6I94_09120</name>
        <name evidence="14" type="ORF">NCTC10207_01777</name>
        <name evidence="12" type="ORF">RA11412_2565</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887795.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88864">
        <property type="protein sequence ID" value="BAV88864"/>
        <property type="gene ID" value="RA11412_2565"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2565"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV88864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT88673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VEI23867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="121" mass="13600" checksum="8DD4CD2351F56DDB" modified="2018-10-10" version="1">MEAKASARYVRVTPMKARRVVNLIRGKQAEEALAILKFAPQAASEPVYKIVASAMANARQKANQEGVAFREEELFISEVYADEGPTMKRIQPRAQGRAYRINKRTSHITVVVATPEKEENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2V0</accession>
    <name>A0A2Z5R2V0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_08480</name>
        <name evidence="1" type="ORF">RA11412_2724</name>
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    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QQT88558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89023">
        <property type="protein sequence ID" value="BAV89023"/>
        <property type="gene ID" value="RA11412_2724"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2724"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="523" mass="58129" checksum="F84A9A0D57768957" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2V8</accession>
    <name>A0A2Z5R2V8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88874">
        <property type="protein sequence ID" value="BAV88874"/>
        <property type="gene ID" value="RA11412_2575"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2575"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="301" mass="33309" checksum="BFFB868FD9BCBFAF" modified="2018-10-10" version="1">MPGQKYPPVAVILGSRESQAPAYGLENSAAVRALQNLTEVLIVRVAEGQDPLADRLVVRVASLLGREYTTTHTLFSSAKTSLRARSQVADLQGVAALISLAPPTETIMISGKIPVIQVADSSFGTRLRAEKRRGGGISRLMSVQARILEKASASGVSLFAVANRWIKDVLIDDLNIPSSKVEVVPMGSFVGESKIIRPTRITDRDVLKLLFVSEDWKRDGGPMILDLYERLVKVRKVQLCIVGDSPEDLLYEIRRVPAPQAMTKPRKCILNTMFFLSLLPRVRMRWLPMRCTVVCQCWGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2W8</accession>
    <name>A0A2Z5R2W8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Cobalt-zinc-cadmium resistance protein CzcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_08730</name>
        <name evidence="7" type="ORF">RA11412_2663</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88962">
        <property type="protein sequence ID" value="BAV88962"/>
        <property type="gene ID" value="RA11412_2663"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2663"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="312" mass="33298" checksum="23A234C43369734A" modified="2018-10-10" version="1">MSSEDQYSSARTRSQNPDLRPRIALAFGLAAAIVVIQFVGSLMTGSLALLTDTAHALTDASGLLVALIAATLALKPATAQRTWGFRRIEVLAALAQATLLMAVGLYAAFEGIHRLFVPPEVPASELLLFGVIGLAANIAGIMVLSGRRDANFNMRAAFLEVLNDALGSVGVIVSSLVIVFTGFMQADAIAGLFIAALIVPRAAKLMRETTGVLMEFSPQGLDLEEVRRHILTVPGVHEVHDIHASTIATGLPVLTAHIVIADKCFTNGEALEILRQARTCVSEHFEVSISHSTFQLENALFGQTEPEETQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2X1</accession>
    <name>A0A2Z5R2X1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_08245</name>
        <name evidence="3" type="ORF">RA11412_2779</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89078">
        <property type="protein sequence ID" value="BAV89078"/>
        <property type="gene ID" value="RA11412_2779"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2779"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340109" evidence="2">
        <location>
            <begin position="32"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV89078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="187" mass="18744" checksum="43957B16D302460D" modified="2018-10-10" version="1">MTAAQNVPVLLVTVLTGVLALALTGCTTSGAGAPTGTASSVAADTEPAENPGGVHTLTFNTDTAVVQTDGSWFVTNPDGTQLHVNPDGSWAATGSDIGTITVNADGSWRWTGSPEGGVIDVNRDRSWTWIGGINKGSMRVKTDGTYDNPGGGGTPVLPAKPGTPTPASAPGAATPKTPINPAIPVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R324</accession>
    <name>A0A2Z5R324_9MICC</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">RA11412_2655</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88954">
        <property type="protein sequence ID" value="BAV88954"/>
        <property type="gene ID" value="RA11412_2655"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2655"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="575" mass="65544" checksum="1343B36CD8C24988" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R352</accession>
    <name>A0A2Z5R352_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmB</name>
        <name evidence="6" type="ORF">I6I94_08185</name>
        <name evidence="7" type="ORF">NCTC10207_01970</name>
        <name evidence="5" type="ORF">RA11412_2793</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
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    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006889129.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89092">
        <property type="protein sequence ID" value="BAV89092"/>
        <property type="gene ID" value="RA11412_2793"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2793"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="PTHR13528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV89092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VEI24223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="78" mass="8621" checksum="FFCDD74E1564EBD0" modified="2018-10-10" version="1">MAAVCQVTGAVPGFGHSISHSHRRNKRRFDPNVQKKTYWVPSLRRKVTLNVSAKGIKVIDVRGIDAVVADIIARGEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R366</accession>
    <name>A0A2Z5R366_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89024">
        <property type="protein sequence ID" value="BAV89024"/>
        <property type="gene ID" value="RA11412_2725"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2725"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="38" mass="4460" checksum="1607320BD17B9162" modified="2018-10-10" version="1">MDAAVELEQELHRPVDLALSIDPRMWQYIEPDLIELPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R388</accession>
    <name>A0A2Z5R388_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87419">
        <property type="protein sequence ID" value="BAV87419"/>
        <property type="gene ID" value="RA11412_1120"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1120"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="283" mass="32391" checksum="4C0241165D00F001" modified="2018-10-10" version="1">MEKTERQAASAPLKARIMLAHAYFQRVANANGIDILHVKGYAFGPEVYRPERHSTDVDLLVRPSHVDRFVQALIAQGWSIQAHFETGSVFEHAMTLHHDAWGLTDIHRFFPGLGENHERVFEQLWLARTTRDIAHRPCTVPSVLDARVIVVLHRARAAAKYSSDLKYLNEIMSYSEWERVHDRALELHSGIAYAAAMGHLAAYRGHRDYLLWKAVSTKVPPYLLWFARVRSARGIAEKARVIRNIALVNEDHLAMTLGHKPSRSEIWRQFFSRFGIKFPKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3A4</accession>
    <name>A0A2Z5R3A4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_08490</name>
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    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
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    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89021">
        <property type="protein sequence ID" value="BAV89021"/>
        <property type="gene ID" value="RA11412_2722"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2722"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="551" mass="60598" checksum="018A36EF6FB9F007" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3Y8</accession>
    <name>A0A2Z5R3Y8_9MICC</name>
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        <submittedName>
            <fullName evidence="4">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1830</name>
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    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88129">
        <property type="protein sequence ID" value="BAV88129"/>
        <property type="gene ID" value="RA11412_1830"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1830"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="rRNA_proc-arch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="rRNA_proc-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="554" mass="62177" checksum="D7D96AF475F0B0C5" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R436</accession>
    <name>A0A2Z5R436_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-oxoglutarate/malate translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_1960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88259">
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        <property type="gene ID" value="RA11412_1960"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1960"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="133"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="199" mass="20930" checksum="2EB650A00BD7A167" modified="2018-10-10" version="1">MITGTMTAKKEALAGFGNSAIWIIVAAFFIADGFLITGLGKRIALLFVSLLGKSSLGLSYGMAITDLVLAPATPSNTARAGGVIYPIIKSLAEVNGSTNESTESRRKLGSFLLMTEAQVNTITSAMFLTAMAGNPLAVKFAQDKGVHLDWGTWALAAIVPGLAALIVLPWVMSKIYPPTIKKTPDAPHTPVKSLKTLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4A8</accession>
    <name>A0A2Z5R4A8_9MICC</name>
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        <submittedName>
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    <gene>
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    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
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    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88439">
        <property type="protein sequence ID" value="BAV88439"/>
        <property type="gene ID" value="RA11412_2140"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2140"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI23296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="75" mass="8158" checksum="EF1E9D520C0187BA" modified="2018-10-10" version="1">MSAEATLRPLLAKYIREEDSLNTAFAEPTTDLFSLGFDSMGAFALLDDLAAEGIAVEFTELVENPTVEFLTSRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4X3</accession>
    <name>A0A2Z5R4X3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88949">
        <property type="protein sequence ID" value="BAV88949"/>
        <property type="gene ID" value="RA11412_2650"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2650"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="505" mass="54949" checksum="9644B6C1B85C01D8" modified="2018-10-10" version="1">MGAHPALHLKPGLLTLTAGGSAHSLFLVPPAFTPEHPYGFSAEATPIILPDEPEPQGMCFHFTADESQLLVRVCGSSLWEQETHYATAAIDRALKLIWAKRDTNTERMACIEAAVTAIHQGMLTDPHLLGPGEYARVGSPDGFISYHLHSAAAPGRITRVLEVDQRYGNPERRTVTEYCAHVLPDHGCLVWQVAAEDARYWSDAMSPLFDAPLTGEQIPEFVREILPYLPSAPIACEYPQPPQVTDYRVTFTPWPVAAAQAERMSAAPDLWGHLVPGELSVERADGKPENLSLYMAVDDAHTLVPGCFFQVPPELPEDPAGGLAFSFRRTAQHGELLLVASAAETVWSPNGVGEIAVARLDSSLNLTWEVRDTVPGRAELIEAVFEVMHTIPGTVPPIVPEGECLHLPHRFDVAEEFGTYHYCHDGVMVRAFMVGAGWVDGDVQLYQAQVQTTDGTGVLVWGTGSYGARYWKAPGHQAYFPPLTGDEIPAPVRALSAHLPPAGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVA0</accession>
    <name>A0A2Z5QVA0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86318">
        <property type="protein sequence ID" value="BAV86318"/>
        <property type="gene ID" value="RA11412_0019"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0019"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="61" mass="6783" checksum="DB65BA0BBE3245AA" modified="2018-10-10" version="1">MAQVHARRIPALPQGHKVLHGCNLRPRPQTPRTPRGPGRHGTLDRVKDSLSYTPAPQTTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVD3</accession>
    <name>A0A2Z5QVD3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86341">
        <property type="protein sequence ID" value="BAV86341"/>
        <property type="gene ID" value="RA11412_0042"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0042"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="140" mass="14519" checksum="A757838B4ADED090" modified="2018-10-10" version="1">MSRAQACTENQVSVSLTPGPSTAGSQQYTLSFTNVSAGPCRLKGNPDVAHTNTDGSSIMGISSQLDGNLMNPSGVVLQSGETTTAAMRRVSASSHGDNCVVQNSPKLTVWLPGSGKGYAFDFDQDTCTNVPQLFVGQFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVF8</accession>
    <name>A0A2Z5QVF8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86375">
        <property type="protein sequence ID" value="BAV86375"/>
        <property type="gene ID" value="RA11412_0076"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0076"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="96" mass="10375" checksum="C1254413ADA074CA" modified="2018-10-10" version="1">MPEASPETEVEYSQVRIRRAPSIPAFMILGLVVGLIVAFVSVWFGPGNPSYTFEAVFGVIAVIFGAVGTALGALLGLWLDRRSVKKARIARVEPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVK3</accession>
    <name>A0A2Z5QVK3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Osmosensitive K+ channel histidine kinase KdpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86425">
        <property type="protein sequence ID" value="BAV86425"/>
        <property type="gene ID" value="RA11412_0126"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0126"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0407">Ion channel</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="275" mass="29745" checksum="BFBB46A2E3092035" modified="2018-10-10" version="1">MSIRGYSELYRQGALPNEDAVATAMGRIEAESKRMGQLVEDLLTLARIDERRESKLAPFDMFHLAVDATNDAFATSPDREITLVGLTDDVAPCSAPVVGDEPRMRQVVANLLTNAMRYTPEGSPLEVAVGVRQEAPGCRAPLLRCATTAPVSTVRIVSACSSVSTAPTLHAHGRPGARVWACRLWPQSWSNTTGISVLKRLMEAGPRLWCRCRFWRALAKRSCGTCGAHGDGVRAEPCAPFACAGMFHGLVVWAPLAPQSFIFLHTERVCGGIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVR0</accession>
    <name>A0A2Z5QVR0_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_07490</name>
        <name evidence="4" type="ORF">RA11412_0179</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86478">
        <property type="protein sequence ID" value="BAV86478"/>
        <property type="gene ID" value="RA11412_0179"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0179"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="101" mass="11217" checksum="3D0274E3B79752E3" modified="2018-10-10" version="1">MTTTVSAREFNQNASAALRLAAEEPVFITKRGTPTNVILSIEDYQRLTQPQPRRSLADALSTMSAEAGEIDFEIDREPSTPNPHREVDFAEDGDFFGSEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVT6</accession>
    <name>A0A2Z5QVT6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidinol-phosphate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86496">
        <property type="protein sequence ID" value="BAV86496"/>
        <property type="gene ID" value="RA11412_0197"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0197"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="324" mass="35076" checksum="532F038FBD3C6344" modified="2018-10-10" version="1">MARILAEFDATHRYPDPLSTKLRTALAHRLGVDAHNIVTGAGSLGALNQILKAFAGASLDGTQDEVIYAWRSFEAYPILVGLLGAKSVQIPNLPNGAHDLNAMAQAVTNRTRVILVCTPNNPTGPAVTEAQMREFLTKIPENVVVVIDEAYYEFCTASTVPAGQNAPVNGLNLLNDHPNVIVLRTFSKAQGLAGLRVGYSVSHPQLTQYLRVAATPFAVTALAEAAAVASIEHEEAVMDGVRHIVAERERVVARLHELGYNIPQTYANFVWLPLGEHTEAFNKLAASHALSVRAFDGEGVRVSIGEDEANDRFISICEQFPHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVT7</accession>
    <name>A0A2Z5QVT7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-ketoacid dehydrogenase subunit beta</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Pyruvate dehydrogenase E1 component beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07435</name>
        <name evidence="2" type="ORF">RA11412_0193</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070448791.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86492">
        <property type="protein sequence ID" value="BAV86492"/>
        <property type="gene ID" value="RA11412_0193"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0193"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="11"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="331" mass="36226" checksum="4F3D7169C4FC2B5F" modified="2018-10-10" version="1">MSEQNAQVERLTLAKAITRGLDDAMADNRKVVLIGEDIGKLGGVYRVTEGLLAKHGQKRVMDSPLGEAGIVGTSIGMAMRGYRPVAEIQFDGFVFPAYNQITTQLAKIHNRSDKKYIVPVTIRIPYGGVIGAVEHHSESPEALFAHTAGLRIVTPSSPHDAYWMTRKSIECDDPVIIFEPKRRYWLKGEVNFADTDFDPFQAQVVREGTDATIVAYGPLVPVALAAAEAAVEDGRSIEVIDLRSISPMDVPTVAASVVKTGRLIVAHEAPTFGGMGGELAAAITERCFYSLQAPVLRVGGYYMPYPVPRTEDEYVPDIDRILEAVDRSFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVX6</accession>
    <name>A0A2Z5QVX6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_07165</name>
        <name evidence="1" type="ORF">RA11412_0242</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86541">
        <property type="protein sequence ID" value="BAV86541"/>
        <property type="gene ID" value="RA11412_0242"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0242"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="54" mass="6369" checksum="5DCF9F7A2B200E85" modified="2018-10-10" version="1">MTDKGGNLLWFGIYTGWDRLKEETKVTDTVYQPFRPQSQYCDREMGALRLLQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW38</accession>
    <name>A0A2Z5QW38_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86602">
        <property type="protein sequence ID" value="BAV86602"/>
        <property type="gene ID" value="RA11412_0303"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0303"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="3">
        <location>
            <begin position="140"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="302" mass="31089" checksum="C17EE3BE5EFF5BC0" modified="2018-10-10" version="1">MGGGPAVVRASNKEFSRFAAARVTVVNLSLIVFMLPTTLTGSWVKVTVSAMGALGLASFLPCMVRGVKASVNTRKEMMAARARGEKPSFDGSGVQPDPVNHTRHSLFGVLAVVLALTLGIAVDPSSVGFNLMGGSTATGTGQTTTVKVKATSNYRFTPDTAQVPVGNRLVVEVTNEDQGMTHDLTFNNGAKTGTINPGETKSVDVGVITADSEGWCSVAGHRQQGMLFHVKATGSNLQANGHHGGGASGGGAGSNGSGSNVMTAQNGNVDLHASPERAMSGVTRCCSPYLRVRSVTGRPCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW96</accession>
    <name>A0A2Z5QW96_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_06580</name>
        <name evidence="1" type="ORF">RA11412_0379</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86678">
        <property type="protein sequence ID" value="BAV86678"/>
        <property type="gene ID" value="RA11412_0379"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0379"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="225" mass="26133" checksum="0845BC9A94534597" modified="2018-10-10" version="1">MADNYTYRDVSSGEAFREHLGSLGWSKPRKNQPVFIQEYGEDLIFRAAFLYATFNHTPGNYSGIPAFYVMSKKWRKTLRKISAHLDQPLKSVPSPHDGDLYFISVGHPRYHEFVDHEARMTYLRPDGTLNIEAFTCFSTAAHRFMETFDLADYVALTGQELQQQRLDTVLPDVLGYLSVNTMNDLRDELYRNVHAHLTDRDATLFADQHVLRRRWDVIADYFSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWA1</accession>
    <name>A0A2Z5QWA1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86623">
        <property type="protein sequence ID" value="BAV86623"/>
        <property type="gene ID" value="RA11412_0324"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0324"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="50" mass="5492" checksum="AA307EDEDFA003C0" modified="2018-10-10" version="1">MSDGRARDISSDKREITDDAEMHLTYKDNKWVISTDASLSSSATSGTNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWD9</accession>
    <name>A0A2Z5QWD9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86712">
        <property type="protein sequence ID" value="BAV86712"/>
        <property type="gene ID" value="RA11412_0413"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0413"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="76" mass="8828" checksum="ADFC205E360459A8" modified="2018-10-10" version="1">MGKRLIIEQLYDQQGNISVALIPVLQLDMWEHAFYLDYQNVKGDYVKAFWNIVNWADVAERFARAVSQTKGLVLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWF1</accession>
    <name>A0A2Z5QWF1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-O-lysylphosphatidylglycerol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86722">
        <property type="protein sequence ID" value="BAV86722"/>
        <property type="gene ID" value="RA11412_0423"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0423"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="103" mass="11337" checksum="AEFF2729EDA4268C" modified="2018-10-10" version="1">MGLVERWDLVINGMEMGTAYSELADALVQRERLVAQSLKAAAGDPEAMQVDEDFLYALETGLPPTGGLGIGIDRLVMLMAQTQIRGVLSFPFVKPLKHDTRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWG5</accession>
    <name>A0A2Z5QWG5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06410</name>
        <name evidence="2" type="ORF">RA11412_0421</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86720">
        <property type="protein sequence ID" value="BAV86720"/>
        <property type="gene ID" value="RA11412_0421"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0421"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="373" mass="41195" checksum="1225B663604951C0" modified="2018-10-10" version="1">MIIVKWRVVILLLVPTILCYGWMIFILPRLMRSDGVRKYVLQAVSLTLTCLLTLTSVASYLNLQNKWYPTLESIFADPNAPITDSHYGAPLIPVSQQVSEHTPEQENARGADSVKEALAHAEPGKPLEITVPGRGGTPDMKTFIWLPEGYASHPERTYPVILGLSGYPGWPLGFEQLAAKLKPGASRPIGDVILVAPDIFYNGIDTECVDSTNPKGPQVESTIVESLIPLLKTTLRVSTEADGWLSWGYSSGGFCGPMLAIRHPDLIGAAVSFAGYFAPQYLEGQQWRPTEDTEYDLLRLLREKKPPVKIWFFTAEDDLSIRDEVPAFTQAVQAPTSVQLATVPAGGHRYDVWFSREPAALQWAGTYLAPFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWN0</accession>
    <name>A0A2Z5QWN0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86835">
        <property type="protein sequence ID" value="BAV86835"/>
        <property type="gene ID" value="RA11412_0536"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0536"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="394" mass="43574" checksum="CE429383C44A0CC0" modified="2018-10-10" version="1">MTVNEDGSWKYHAGSDDLTVNADGTWSYRSKTFGQREATLHANGSWDITNNEYSKQEKMHVNPDGSWDKVTKYEAKEGKAAEEHHEQVRSDGSWEQKGPYQTIVGSADGTVTLTYSDGKQGSTFSSSEWSLVEPFDYKELIFVQKDHNIKYGVGDGGVIPLMPRAPLPRGVKAAQAPVGSEQERIALAQQQRLVLTDDNKAGKEPRRRKTESYDQGLDNVDLKDDGSYSYSTKEGDATAEVAADGTWKAKSSDGNTATLNADGSWDSYTEKPTVNTKESKMNVHVNSDGTWVKNFGKNVRAQMFADGSWCYDLRIGDGESSAYYGAYYGTPEGKIYGLGTDGEWHEADYKMWDERRDYEYIEPPHAATVVSPVKDGVVPLMPRVAVAAGQKAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWP9</accession>
    <name>A0A2Z5QWP9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_06040</name>
        <name evidence="1" type="ORF">RA11412_0501</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86800">
        <property type="protein sequence ID" value="BAV86800"/>
        <property type="gene ID" value="RA11412_0501"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0501"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028037">
        <property type="entry name" value="Antitoxin_Rv0909/MT0933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14013">
        <property type="entry name" value="MT0933_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="54" mass="5863" checksum="27C32D558BF20B59" modified="2018-10-10" version="1">MGFDIKGTVDQGLDKAKDVVNDKAGKEVVTDEHVDKASEAVNENVQKLTDKFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWQ8</accession>
    <name>A0A2Z5QWQ8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Organic hydroperoxide resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86810">
        <property type="protein sequence ID" value="BAV86810"/>
        <property type="gene ID" value="RA11412_0511"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0511"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="52" mass="5254" checksum="54238575CE074F49" modified="2018-10-10" version="1">MLPLGTKLVAGRAKANTTDSTVGARVSLGSNDNGGFQLAVVLEVSIPNVSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWS1</accession>
    <name>A0A2Z5QWS1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-ribbon-containing possibly RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86783">
        <property type="protein sequence ID" value="BAV86783"/>
        <property type="gene ID" value="RA11412_0484"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0484"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="66" mass="7367" checksum="EE4F2A64D7F2D71D" modified="2018-10-10" version="1">MEVRCDSTAWATQLRLMQRQIVQMFDRELGAGVVSSVRIFGPNNGRWSSRGPKRAPGGRGVRDTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWT2</accession>
    <name>A0A2Z5QWT2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86895">
        <property type="protein sequence ID" value="BAV86895"/>
        <property type="gene ID" value="RA11412_0596"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0596"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029455">
        <property type="entry name" value="GHL15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14885">
        <property type="entry name" value="GHL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="205" mass="22441" checksum="93F4075AD56C948A" modified="2018-10-10" version="1">MDSVVKELRDSPFDGVMGDNDIESDYYGLNLPIRNVDSMATVRAGLDHLIEYAGAELNKAGKILVPNIAEARLRWGKWEAHSAYGGGFEEVWLGWGAQEFLDSTYAMLQSRHIGRGAQGQVRLAYDEGLQRADRTAPKVTILRTPSGGPKAPVTGTDENLLYGLAGFWIFGGGRFTGIAVTEHDSYNGTPFSPEMSYDLGTPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWU1</accession>
    <name>A0A2Z5QWU1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86905">
        <property type="protein sequence ID" value="BAV86905"/>
        <property type="gene ID" value="RA11412_0606"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0606"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="283" mass="29818" checksum="CDFD288EB48135AE" modified="2018-10-10" version="1">MNVAVGVSRLGHPTQFVGHYGADDYGRAISEHLEASGVNVPFAPTAARTSTAQAHIGQDGAAEYEFNIDWSLDALADELVELARTSQALHTGSIAAMLEPGAHVVANALTAARESALISYDPNCRPSIVSDRAAAQEWAERFVGLASVVKASDEDLTWLYPDRSLAETARAWVALGAELVVLTRGERGPIAYTRTYPEGIEEPAYRVQVADTVGAGDSLMAALICGLLDRGIAGSGARAKVAALEREEISELLRFSATAAGITVSRSGANPPNRHELLAVLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWU4</accession>
    <name>A0A2Z5QWU4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MMPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0551</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86850">
        <property type="protein sequence ID" value="BAV86850"/>
        <property type="gene ID" value="RA11412_0551"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0551"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="86"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="432" mass="46295" checksum="253CCC94DEC9334E" modified="2018-10-10" version="1">MLSLIGRKVMSKKAWASVDTPEKIAARHTEQEQREESPHGWLKIVLAKPVVTILLCVVALGAIAIPMGQMRMGLPSAESSQTESTEYKAYQIVKDKFGEGMSGPVLAVAHTPSGMSEAQAEQAQIDIARAIEAKDPDNVKTVVPAGQTDDHTVQIFQVIPKHGPSSVETVNLVEQLREVHVNVQGTDVKLGVTGLTGGNIDVSNTLAQKLPLYLAVVMGLSFIVLILVFRSILVPLVASVGFLFSILASFGAVVAVYQMGFMGSLFGVHDPGPILAFLPTLMIGILFGLAMDYQVFLVSGMREAYVHGKDAKTAVVAGYNHAVRVVIAAMIIMISVFGGFIFAESAMIRPIGFGLAFGVLVDAFVVRMTITPAVLTLLGDKAWWMPKWLDKLVPNMDVEGATLLDTLEEEAEQPADHDEQAETAKSTVGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWV4</accession>
    <name>A0A2Z5QWV4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05655</name>
        <name evidence="2" type="ORF">RA11412_0609</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86908">
        <property type="protein sequence ID" value="BAV86908"/>
        <property type="gene ID" value="RA11412_0609"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0609"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="104" mass="11738" checksum="6E4862D4E0528361" modified="2018-10-10" version="1">MAYIPTKVRRAARTIGEQLRIQRKLMGLTAQMVAERADITTVTLRRIEQGESVRTDVLFRVLRVLGMLDAVVTATDPYLTDVGRLRAGEKLPKSVRIPKSEMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWX7</accession>
    <name>A0A2Z5QWX7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MATE family efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_05500</name>
        <name evidence="7" type="ORF">RA11412_0646</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86945">
        <property type="protein sequence ID" value="BAV86945"/>
        <property type="gene ID" value="RA11412_0646"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0646"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13136">
        <property type="entry name" value="MATE_DinF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PTHR42893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV86945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="500" mass="52997" checksum="8852B24BB2E7F794" modified="2018-10-10" version="1">MSNKASEPNTSGAANTADGTASTHEPQNLLDATPRTGSIPLHLGEGEAESGKTQPEKSLNRRILALAVPAFGALIAEPLFVLADSALVGQLGTETLAGMSIAATLITTVVGLMNFLAYSVTPAVARAFGAHRLAHAYRIGVDGMWVALGLGLLIMGVGYIFADPALRGMGANDATIGYARDYLHHSLWGIPPMMMILALMGTLRGLQDTVTPLKVAGVGTVVNVALNWVLIYPVGWGVAGSATGTSLTQWGMALALGIFIHLKMRPQGVTWRPDIAGMRGVLSLGSWLMLRTLSMRLALLSTVFVVARLGDEQTAAYQLGMSVFNLLLFALDSLAIAAQALLGKELGERDLTAESGRAKVRELKNRLVRMSLVYGVVTGVVAPVIGFFGNWIFTQDAPVATLFAWATLVIGVGQPIAAYVFVLDGILMGAQDVKYLAIGSFVMLVVYAPVIFGIYWAVSGGLLSATVGYLGLWAAYILWYQGVRAFIFGRRAASDVWIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX01</accession>
    <name>A0A2Z5QX01_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86967">
        <property type="protein sequence ID" value="BAV86967"/>
        <property type="gene ID" value="RA11412_0668"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0668"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="48" mass="5491" checksum="3CE98515621E19E7" modified="2018-10-10" version="1">MKDSPDYGVLLRLSEELEQITGYPVDVLTSIKPVFRPYIEPDLTELPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX14</accession>
    <name>A0A2Z5QX14_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86921">
        <property type="protein sequence ID" value="BAV86921"/>
        <property type="gene ID" value="RA11412_0622"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0622"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="48" mass="4900" checksum="ABAE543F077E3D01" modified="2018-10-10" version="1">MNDAGLLEGAQYAVAVGSHEALLPLADLTVDPHPDAVAAAIRALAEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX24</accession>
    <name>A0A2Z5QX24_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86893">
        <property type="protein sequence ID" value="BAV86893"/>
        <property type="gene ID" value="RA11412_0594"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0594"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022622">
        <property type="entry name" value="DUF3492"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11997">
        <property type="entry name" value="DUF3492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3492" evidence="2">
        <location>
            <begin position="25"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="273"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="473" mass="54149" checksum="E20BFE65B5A9195F" modified="2018-10-10" version="1">MRVIYLSMEEFKEEFAHDCDPTHLRMNARQRKKLVRRILEAFSALVKGDMNPLWDLYDEGINPRTRSFPLFSVVGSREFMEAMGTWGFLSEIPLTELFWKVRDFTSLLYALLRQNMPYARVYHAHTTGYASLIAAAAARDYGSKFLLTEHNLYVRDTANTKLERPMDKPVTADYKLFMERPVTFDERVWVTWFVEMGRFCYPSADMITYLYPKALEEARGLGAPIDQLNPGDREDHAIILPNGMLIESVHSALEARMAARMKIFEDARNHVWRFVFIARVVPIKGLADLIRTLAQMRDAGIMNFHLDVLGPTDHRIDYYQQCLNLIEDLGMGQFITFHGTVKVRQMLANYDLLLMPSYNEGQPVVALEAMAASIPLVSTDVGGMSQLIDDILDASDGKEIGNCGILTVPGDVTGFARALRIIMETPGLYEQYSRNAYARVEKFFQLSLVMEHYNRIYRKLGGLPARPSKYTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX25</accession>
    <name>A0A2Z5QX25_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86995">
        <property type="protein sequence ID" value="BAV86995"/>
        <property type="gene ID" value="RA11412_0696"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0696"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="41" mass="4043" checksum="494C1533C7117ECA" modified="2018-10-10" version="1">MHSVVAAAGCGGAGANSFTASVFFSGSNNTPRSPNNGEQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX27</accession>
    <name>A0A2Z5QX27_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_05775</name>
        <name evidence="4" type="ORF">RA11412_0577</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86876">
        <property type="protein sequence ID" value="BAV86876"/>
        <property type="gene ID" value="RA11412_0577"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0577"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="23"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="419" mass="46625" checksum="76F39B3602B323C6" modified="2018-10-10" version="1">MPHHHAVRRYPTLYEAVFERANSLNFLRLVLASFVILSHTPYIVMGAKVDAHPLLHEFYVFGDFAVNAFFCISGFLIAHSAYRSGAGSYLVKRVLRIFPGFWASLLFVVAIGGPLSILTGHAATGWNWADAISYIRRNYDLMALQYPLFGGPANVPFDSPSWNGSVWTLEYEFFCYLLLLPLFYLPFVRKHLKVFIPLAYAISLSYYLCNQYLGYDFMSQAFGMHPRDLNASARLYPFFFAGSLLYMLSRRIKIYPIISAVAAVVCTAAGFYFTWLVPHANIMQWTQLILAYGVITLGCVMNIPLGRTNDISYGVYVYAWPVQQILVLLGSVSLGLAANIVLDVVLTFGVAWLSWKLVEKPAMNLARHPVVTGAKRAAPQSAAAPCAPKTPEPEPQGTPATADTNRVKPAAHPVLPPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX44</accession>
    <name>A0A2Z5QX44_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86896">
        <property type="protein sequence ID" value="BAV86896"/>
        <property type="gene ID" value="RA11412_0597"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0597"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="52" mass="5615" checksum="459CC4C8B02E2E44" modified="2018-10-10" version="1">MHARAFTHGWAAINLGTTSRMVRVPSGLKDAAGNTPPSTLTLQAHRGVLYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX66</accession>
    <name>A0A2Z5QX66_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_05085</name>
        <name evidence="1" type="ORF">RA11412_0738</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87037">
        <property type="protein sequence ID" value="BAV87037"/>
        <property type="gene ID" value="RA11412_0738"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0738"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="233" mass="25292" checksum="E85DAC54E4DAB292" modified="2018-10-10" version="1">MVPSTPRSYHRPVLASHEIFERQAGGENPAAQHEAAYASARVLLARGRANTDPQVAQRLVDFTDEYGLETLALMWASAPAQSLPGALWRMYSLRDAVHRDAPAVSRAFAKGLEDDYRSHVLAGVPDPPSAWEVVATADSILAGVYEGEVDIALERFAAFARVVALGLQAEYAAGDIARAAGVHVPLAPSHEVRREGVNRMLSIPERVRRLGQIAEDLEAVALLWRQHGGLEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXB2</accession>
    <name>A0A2Z5QXB2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-keto-acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I6I94_05805</name>
        <name evidence="12" type="ORF">RA11412_0565</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86864">
        <property type="protein sequence ID" value="BAV86864"/>
        <property type="gene ID" value="RA11412_0565"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0565"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="TPP_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PTHR43452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="204"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="398"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV86864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT88078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="565" mass="60477" checksum="C8B80A3917D0C0C2" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXC3</accession>
    <name>A0A2Z5QXC3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytolysin B transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RA11412_0798</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87097">
        <property type="protein sequence ID" value="BAV87097"/>
        <property type="gene ID" value="RA11412_0798"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0798"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03412">
        <property type="entry name" value="Peptidase_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50990">
        <property type="entry name" value="PEPTIDASE_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C39" evidence="11">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="138"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="450"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="484"/>
            <end position="491"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV87097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="769" mass="84724" checksum="3A5D8A45627BCF93" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXE1</accession>
    <name>A0A2Z5QXE1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Oligopeptide transport system permease protein OppC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_04690</name>
        <name evidence="8" type="ORF">RA11412_0826</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87125">
        <property type="protein sequence ID" value="BAV87125"/>
        <property type="gene ID" value="RA11412_0826"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0826"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="97"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT89896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="352" mass="39069" checksum="320A949AC4648853" modified="2018-10-10" version="1">MSQVTETHAIPVVKGDDFKVINKKVIILRRFMRNKLAVFGLGLFVLMFLFGMFGQYFTSYTPTQIDYLALGEEPSTTHFFGTNAAGNDLYAQMVEGVRVSLLIGVVVGTTSIAISAVYGCIMAYFGGWIDKVMLFILEVMIMVPSLLILAIAMNSGIGKEIQKNVPAWIVLSAVLIIFNWMSPARLIRAMGQSLIGRDYVKGARYMGVHPFKIVMRHLIPNIGSLLVLEFTRGIMYAVLAEVVYSFIGIGIRYPNYSLGSLISEASQQINTLPHMFWFPIIFFFLIVAPLAFMNDGLRDAFDPTSMSVGSIKKEKKNKKAKKVETVKPAESLTTAEPDASESEAKKEEVKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXF0</accession>
    <name>A0A2Z5QXF0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oligopeptide ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87127">
        <property type="protein sequence ID" value="BAV87127"/>
        <property type="gene ID" value="RA11412_0828"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0828"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="317" mass="35346" checksum="143B925CBCA5ADF9" modified="2018-10-10" version="1">MVANEKWWGEKPLLDRIIFRALEAGASRAAFKNGEIDAVVASTPTAYAELKDTNGAQIRRGQRLFSGGLNLNPKHIKDAKVRKAIFVGTDRQALANVNFQGLPYEEDVPGSMVLMPFSPLYEDNFPKPEGGDRKAAAQKILEEAGYTKGSDGFYEKDGKKLEYRVTVFSDDPTSKNVGQNFVEIMKNIGLHIELNPEAGLNFNKVISNKEYDITFSGYSVGAEPTAGTQQFYYSKDNDGVGTPEIDKLIEKILVEPDPQKRAQKCNEVEKKHMSEVCTLGTVYNGPLYTMCKEKLANYGTFLYDESNIDWAKVGWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXL2</accession>
    <name>A0A2Z5QXL2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipid A export ATP-binding/permease protein MsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87188">
        <property type="protein sequence ID" value="BAV87188"/>
        <property type="gene ID" value="RA11412_0889"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0889"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="135" mass="13862" checksum="2A8BC355FAE6C429" modified="2018-10-10" version="1">MARALAARPAVLLLDDPFSALDVGTEERIITNLRGGEGNLGGATTLLTAHRPSTVALADRVLLLEGGKIVADGTHTELMKLPAYRALMSAEPEAPASLAHIADMLFGIAESEVSAAAESTQNREGSPTGEGGGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXQ8</accession>
    <name>A0A2Z5QXQ8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_04815</name>
        <name evidence="2" type="ORF">RA11412_0801</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87100">
        <property type="protein sequence ID" value="BAV87100"/>
        <property type="gene ID" value="RA11412_0801"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0801"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="293" mass="31786" checksum="BF24E6E2A0C8624C" modified="2018-10-10" version="1">MRLEKINVLYCVLAVYCVCFIFRIYEYFVLRTDQSFWGEAFVHKLIGIGILGLVMQACSLGARSIGFTREHIMRPILAGLGFGAVVFAIAYVAEIALLPPTEFRSLDVYVSTYAVSSNTGHQTALIFFVICLAGNVINVVMEEGVFRGLFQKLLGFRYSFMGAAAISSVLFGLWHVIAPVRNYTDGTSSLGGAVMNALILMLTSAVVGFKFALMTRLTGSLYMAMANHCANNVIVNLVHVTSVSGEDTLMFVRISIAQGLSFLVVAVWYLVASRRGSLPAAGIEGAPASHPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXX4</accession>
    <name>A0A2Z5QXX4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein GrpE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0993</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87292">
        <property type="protein sequence ID" value="BAV87292"/>
        <property type="gene ID" value="RA11412_0993"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0993"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="159" mass="17292" checksum="FA0AE5D15B7ECF0F" modified="2018-10-10" version="1">MAEHENTAGDPLEEAFNAPAAEGHPEAEEAPAATDQAAAGETPEPSEEAPSEDAKLAAERLDSLLRLQAEFTNFKNRAAREKEQLREFVASDIVSLLLPVLDDIDAARKHGDLKEGPFAAIATKLEESLKKKAWNASARWASPSTRIFTKRSCNSRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXX6</accession>
    <name>A0A2Z5QXX6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="4">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xth</name>
        <name evidence="4" type="ORF">I6I94_03965</name>
        <name evidence="3" type="ORF">RA11412_1018</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87317">
        <property type="protein sequence ID" value="BAV87317"/>
        <property type="gene ID" value="RA11412_1018"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1018"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="282" mass="31585" checksum="0549CC40CE994DEB" modified="2018-10-10" version="1">MSRAAKTLRVASVNVNGIRAAYRKDMATWLAGRDVDILCLQEVRAPDTIVRELLNEDDWHILHAEAAAKGRAGVLVATRKHPNANGELLKNQPVATRSTIGDDYFADAGRWVEADYTLPTGETLTVVSAYVHSGEVGTPRQDDKYRFLDRMLVRLPELAQHSDHVLIVGDLNVGHTELDIKNWKANQKRAGFLPEERAYFDKFFGDIGYEDVARKLAGEVPGPYTWWSYRGKAFDNDAGWRIDYHMATPALAAKAVEATVDRAASYDERFSDHAPLVVDYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY04</accession>
    <name>A0A2Z5QY04_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87338">
        <property type="protein sequence ID" value="BAV87338"/>
        <property type="gene ID" value="RA11412_1039"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1039"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="222" mass="23092" checksum="8EAF8C2BF7ABD9F1" modified="2018-10-10" version="1">MEGIQQILGIEPEVISGTEEASLSFAGAMRAVGAGDKNTLVFDLGGGSTEFVLGGGRGAEAKVISSRSVNVGCVRLTERHMVSAPVTDEQVRRVEADTDAAIETVVSSVPLSTATRAVAVAGTATTLAAAALGLETYDSEAINGTSLSLETVQCTAQMLRSMTRQERAELGYMHPGRVDVIGAGVTIYARILTRLNEITDGVINSVTVSEHDILDGIALSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYI0</accession>
    <name>A0A2Z5QYI0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Membrane-associated zinc metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">RA11412_1228</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87527">
        <property type="protein sequence ID" value="BAV87527"/>
        <property type="gene ID" value="RA11412_1228"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1228"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="11">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV87527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="187" mass="19807" checksum="F31A3CE308F5012A" modified="2018-10-10" version="1">MEILYYAAGVIIMAFAIAVSIALHEVGHLVPAKLFGVHVPQYMIGFGKTIFSFRRGETEYGFKAIPLGGYISMIGMYPPAVQEKTDASAEEDASTEREKVTASAAAGTVAGQAVSETAELTGDTAEPAENTLYPSGRCVPGTPACWHRSLLLPVRRMPNVSSLAMRTVSSISCRCISALSLCSAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYJ6</accession>
    <name>A0A2Z5QYJ6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">infB</name>
        <name evidence="12" type="ORF">I6I94_03135</name>
        <name evidence="11" type="ORF">RA11412_1239</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87538">
        <property type="protein sequence ID" value="BAV87538"/>
        <property type="gene ID" value="RA11412_1239"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1239"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="420"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="51"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="429"/>
            <end position="436"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="479"/>
            <end position="483"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="533"/>
            <end position="536"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAV87538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QQT89621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="927" mass="97097" checksum="1CFC968D4385C9C2" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYN9</accession>
    <name>A0A2Z5QYN9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathionylspermidine synthase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Similarity with glutathionylspermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_03420</name>
        <name evidence="2" type="ORF">RA11412_1167</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87466">
        <property type="protein sequence ID" value="BAV87466"/>
        <property type="gene ID" value="RA11412_1167"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="GSPS_pre-ATP-grasp-like_dom"/>
    </dbReference>
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        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03738">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSP_synth" evidence="1">
        <location>
            <begin position="13"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="406" mass="46584" checksum="0C56AECFBDDC900F" modified="2018-10-10" version="1">MRREEFPAHRPGWEQTIDEEGLTYSIDFPGDTHYWNEYAAYVFTPDEMDSIRVQSEQIHKMCLNAVEYMASGAFGTLGLPEPAFQLAIESWNQQDPDFYGRFDFTYSGIPGDPLKLLEYNADTPTGIIEAAICQKTWYQQQRLDAQGYGHWGEIGEAFTERWRQIFAAETTPQLHLAHVNESIDPYQEDYNNVWLIAHAAQLAGVKTKLIPIDEIIFNEDTKSWSDADGKPINNLFKLYPWEDLVTDSESGYDKLLFAYHGSIRRWVEPAWKMFLSNKLLLAALWEMYPNHPNLVPAYAGRSGGLTNWVRKPIFGREGDGIEVHAPDHGIFSRDEEDEHFIHAPESEFVYQQYIPAPLYSGLMQPTNHPMLGVWMVNGRAVGMGIRESDGPVTDYYCRFAPHLVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYX4</accession>
    <name>A0A2Z5QYX4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylated-DNA-protein-cysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87652">
        <property type="protein sequence ID" value="BAV87652"/>
        <property type="gene ID" value="RA11412_1353"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1353"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="39" mass="4392" checksum="62EF8E880A0E8704" modified="2018-10-10" version="1">MGRLYMAASDNALTGIWYEEQAHFPLPMSWANVLPTPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ25</accession>
    <name>A0A2Z5QZ25_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_02810</name>
        <name evidence="2" type="ORF">RA11412_1317</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87616">
        <property type="protein sequence ID" value="BAV87616"/>
        <property type="gene ID" value="RA11412_1317"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1317"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="138" mass="15100" checksum="FBAB73C7D71B4FEF" modified="2018-10-10" version="1">MNTQIPQPSQDTHLTSQDLDFLNSIFDLVRDNKPLALTSLLDQGIPVNLTNSNGDTLLILAAYHEHEDMVRILIDAGADLNRLNDRGQTALVCAVFRDNEPIAQALLKAGADPHLGTQTPAQVAQFFDLPSMQKLLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ33</accession>
    <name>A0A2Z5QZ33_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">dapA</name>
        <name evidence="13" type="ORF">I6I94_03030</name>
        <name evidence="12" type="ORF">RA11412_1262</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888957.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87561">
        <property type="protein sequence ID" value="BAV87561"/>
        <property type="gene ID" value="RA11412_1262"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1262"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV87561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT89602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="330" mass="35141" checksum="A348BD8DFD21EC2F" modified="2018-10-10" version="1">MSDSAVNTETSNRPVNSAGGLKTPHNQGTFATPIFGRLLTAMVTPFAADGSVDEAQTVKLAEYLVDNGHDGLVVCGTTGEYSTMTDDENERVFQIVKDAVGHRAKIVAGVGSNDTAHTIELARRADKVGVDGLLVVTPYYNKPTQAGVFAHYQAVAKTSDTPIMVYDIPGRSAIPIEPDTYRRMAEIDSIVAVKDAKADFGAASEVMATTDLQYYSGDDGLTLPWMSVGAVGLVSVTAHVAPQLFRELIDAVVAQDLVTAQRVHLLLTPIVRATMSRAPGCVSAKQILSWQGVLGTPVVRLPHVLSEPAVVEAMRSDLRDSVIAHSIQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZH5</accession>
    <name>A0A2Z5QZH5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1559</name>
        <name evidence="2" type="ORF">RA11412_1569</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87858">
        <property type="protein sequence ID" value="BAV87858"/>
        <property type="gene ID" value="RA11412_1559"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87868">
        <property type="protein sequence ID" value="BAV87868"/>
        <property type="gene ID" value="RA11412_1569"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1559"/>
    <dbReference type="KEGG" id="raj:RA11412_1569"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="38" mass="4545" checksum="B48303E4A2877826" modified="2018-10-10" version="1">MQLLNPEKRDAVILRWSRDFLYGYEPKKSKTSEETSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZI2</accession>
    <name>A0A2Z5QZI2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">2-acyl-glycerophospho-ethanolamine acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NCTC10207_00778</name>
        <name evidence="2" type="ORF">RA11412_1381</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87680">
        <property type="protein sequence ID" value="BAV87680"/>
        <property type="gene ID" value="RA11412_1381"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1381"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="41"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VEI22693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <sequence length="253" mass="27155" checksum="226011AB7C64CCD4" modified="2018-10-10" version="1">MVTHPATTPVYAVLKAISDPTVRRIWPHEVIGAENMPNGPAIIASNHLAFCDSVFIPLAVKPTVNFLAKSDYFTTPGFKGRAMAAFFRSVGQLPMDRSGGEKSRASLEAGLKVLRAGGVLGIYPEGTRSPDGRYYRPKIGVARLALESGAPVVPVGQLGTDLIQPAGTNRPRFRHNGKPITVRTIIGKPLEFAHLQDKANDHATLRAVTDQIAEAIRALSGQQYVPVPADKVKRLMAAHGWSAQTAVASLLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZK0</accession>
    <name>A0A2Z5QZK0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87711">
        <property type="protein sequence ID" value="BAV87711"/>
        <property type="gene ID" value="RA11412_1412"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1412"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="158" mass="17498" checksum="F550C22AEE32D87F" modified="2018-10-10" version="1">MNEVDDFLDELVGELRRLNAENNSLRRKLEDCESRKGGASTSETTAAAAAPAGGGSQDAAGLLAMAQKVHDDYVSQGERTKAELIAEAEKKANQLVVEAEIKREKALSALKEEQANLKSSVESLRGFESRYRTQLQEHLNRQLDDLRHLKSIEAEARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZL3</accession>
    <name>A0A2Z5QZL3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnhB</name>
        <name evidence="15" type="ORF">I6I94_01695</name>
        <name evidence="14" type="ORF">RA11412_1613</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87912">
        <property type="protein sequence ID" value="BAV87912"/>
        <property type="gene ID" value="RA11412_1613"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1613"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="26"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV87912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QQT89375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="263" mass="28683" checksum="855266BA3E6F3E1F" modified="2018-10-10" version="1">MTGSQAPAATLEHEHDLFAAGYQLVAGVDEVGRGSLAGVLSVGVAVIGAQAQLQVAGLIDSKALSPARREKMVPEIRRWCLNAVGHVSPAEIDELGMTLSLRLAAQRALACLGREGTTPEVVLLDGKHDWLSAPAPDLFGHQDPAHQRYEELLQQAWGRRNTPWQGPVHTIIKGDYRCASIAAASVLAKVERDGLMRDLSTRYPEYGWENNKGYGSAAHRAAISEHGPSPLHRLTWALPADEQQVRMAYQRRHAENGVNENER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZT7</accession>
    <name>A0A2Z5QZT7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88015">
        <property type="protein sequence ID" value="BAV88015"/>
        <property type="gene ID" value="RA11412_1716"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1716"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="115" mass="12926" checksum="ADB1A242360F4DAD" modified="2018-10-10" version="1">MSARSGLNETQVRDALALLASSGQVGFDVQAGEYFHRPLPVQADALQAMHPRLVGAQKLVDSGAVRDDEGGTYRVQSRDTFYTVTPAEKIEEYRCTCPWWVKYRGTRGPANMYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R080</accession>
    <name>A0A2Z5R080_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6493 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88023">
        <property type="protein sequence ID" value="BAV88023"/>
        <property type="gene ID" value="RA11412_1724"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1724"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="152" mass="17238" checksum="6D90E28171D45D8A" modified="2018-10-10" version="1">MWACFTDEGLLRKDWSGRENADILALFHTLQENFDGFRDRLLTECLKAMLRDFSAKNTSIFHHVYRGMNPTPDENLGNTNLLTSVLTTVPSTSVGLAQEKLMSCVDKLTEPQIHDLLNASHTVLLRTEKKYSGRRSHSLALLLKCTQSILKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0A6</accession>
    <name>A0A2Z5R0A6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88195">
        <property type="protein sequence ID" value="BAV88195"/>
        <property type="gene ID" value="RA11412_1896"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1896"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="84" mass="9159" checksum="E8194A5E2F9AD657" modified="2018-10-10" version="1">MVDQELLAHKILHVDVTDNMVGVFRSLPTVIEMFSVPLEEIALFVFDTGQDDGSASLTPEEVTAELLHPSPGTAAALNRYTFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0D8</accession>
    <name>A0A2Z5R0D8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I6I94_00475</name>
        <name evidence="12" type="ORF">RA11412_1903</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88202">
        <property type="protein sequence ID" value="BAV88202"/>
        <property type="gene ID" value="RA11412_1903"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1903"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="20"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV88202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT89150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="455" mass="49833" checksum="34FED6C8D2762B6D" modified="2018-10-10" version="1">MARKASLSGFPEYLPAERLVENHVLDTLRTTFELHGFSSIETRSVETIEQLLRKGEIDKEVYAISRLQDDNGTKAKEKLALHFDLTVPFARYVVENAGYLNFPFSRYQIQKVWRGERPQEGRAREFTQADIDVVGDGELPFRYDVTLALVVVDALSKLPIPDFKLRVNNRKLAEGFYLGLGLTDTAAVLRSIDKLEKIGADAVAQELQREAGASEEQAQAALELAQIRTEDSSFVAQVRELAERYEAEHELLDQGVAELAEVIDEAARRAPGKVLADLSIARGLDYYTGTVYETVLVGHESLGSICSGGRYESLASNGKKTYPGVGLSIGVTRLVARILSQGFAQATRKVPSAVFIALTNEEGWSAANDVADALRARGIACEVSANAAKFGKQIKYAEKRGIPFVWFISTGDNGELAHEVKDIRSGEQVAADPASWMPPGEDLNVRVVPAESIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0H8</accession>
    <name>A0A2Z5R0H8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_07920</name>
        <name evidence="2" type="ORF">RA11412_0060</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86359">
        <property type="protein sequence ID" value="BAV86359"/>
        <property type="gene ID" value="RA11412_0060"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0060"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="407" mass="43003" checksum="79F34E851CE0F51F" modified="2018-10-10" version="1">MKKLTQYVKTPLLLITLIDGFADASFGLILIVYISRIAEPWWLTVMAVGGFFTGILFGPFTGWVADRFSGRTCWSGSLAVSSLCVAVIAFFPHPVTIVAMSVFNGAAGNLTNAAEFKLLPKAPGMTPSSASASIVGIGSFCSIVAPPVGAFFATWNMTATIVGSSVFLLTAAVIAWFNVPAQPDHELSDAIKRDSFKDIFLGFSAISSARALVVFLPVMAVVVASTTMEGIAGVFYLQSITNTAFEYSLVLAMWAVGALIASVFYGRGWYKPQLVNAILWGGFFIGAAILLEGLVANPWIVGAGFLVGGFFNSIHNMGIRDMVYTRVPEHRQGQSWALIGSLFSSMVLVGDLLGTPGILGDARTIVMIGGATATGAAVANLLLYALVHSRVGQAQGEKTGHCPFESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0L2</accession>
    <name>A0A2Z5R0L2_9MICC</name>
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        <recommendedName>
            <fullName evidence="1">DUF6493 domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="2" type="ORF">RA11412_1717</name>
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    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88016">
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        <property type="gene ID" value="RA11412_1717"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1717"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="153"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="515" mass="58723" checksum="E30DF313573BB90F" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0P5</accession>
    <name>A0A2Z5R0P5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FeS assembly SUF system protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Metal-sulfur cluster assembly factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">PaaD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_01055</name>
        <name evidence="4" type="ORF">NCTC10207_01095</name>
        <name evidence="2" type="ORF">RA11412_1762</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887140.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88061">
        <property type="protein sequence ID" value="BAV88061"/>
        <property type="gene ID" value="RA11412_1762"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1762"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI22999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="109" mass="12396" checksum="3E918DB86FAB40AE" modified="2018-10-10" version="1">MTETVQARPSQEDIEEALKEVIDPELGVNIVDLGLLYGMRWDDNGTLILDLTLTTAACPLQDVIEEQVQANLDNVVAEWRVNWVWMPPWGPERITEDGRDMMRALGFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Q0</accession>
    <name>A0A2Z5R0Q0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_11175</name>
        <name evidence="2" type="ORF">RA11412_2066</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88365">
        <property type="protein sequence ID" value="BAV88365"/>
        <property type="gene ID" value="RA11412_2066"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2066"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="833" mass="89198" checksum="52EF552E7F0B806F" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0Q4</accession>
    <name>A0A2Z5R0Q4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-aminobutyraldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88120">
        <property type="protein sequence ID" value="BAV88120"/>
        <property type="gene ID" value="RA11412_1821"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1821"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="12"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="240" mass="26246" checksum="300AC0BA4A822167" modified="2018-10-10" version="1">MKRLKNFINGEFVDSASAEELEVVYPVTGETVALAPVSTADEVDAAMRAAQEAFKTWKHTTPADRQLMLLKLADALEKNADALVEAQHRNTGQPREMIRDEEVLAGANQVRFFAGAARTLEGKAAAEYMEGHTSYVRREPVGVVAQVTPWNYPLMMALWKIGPALAAGNTVVLKPSDTTPESTLELAKLIADIFPAGVLMLCSVLALRALRWLIILPPRWCLSPGRCGQAGRWLPVRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R106</accession>
    <name>A0A2Z5R106_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88333">
        <property type="protein sequence ID" value="BAV88333"/>
        <property type="gene ID" value="RA11412_2034"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2034"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="168" mass="17101" checksum="9C373D55BA052DE2" modified="2018-10-10" version="1">MPANPFAPNSQAGKVAVVTGASSGIGRATVQQLTATGWNVYALARRAERLAILEAETGAHPVTCDVTDEAAVRAAAKNILAETGGRVNALVNIAGGAIGLDRVADGSPEDYLAMYRVNVLGILNTVRAFIPALRASGEGSILNLTSTAAEGGYEGGRGTMPPNSVRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R141</accession>
    <name>A0A2Z5R141_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="1">TMP kinase</shortName>
            <shortName evidence="1">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="1">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiL</name>
        <name evidence="5" type="ORF">I6I94_11065</name>
        <name evidence="4" type="ORF">RA11412_2093</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88392">
        <property type="protein sequence ID" value="BAV88392"/>
        <property type="gene ID" value="RA11412_2093"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2093"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="68"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="169"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="399" mass="41748" checksum="6374FF18193CD6BE" modified="2018-10-10" version="1">MSLQKNARTIRDSSQRQEHPLRDATAAALGESRILRAFLPIIENHNAAVKDHQHQQGAEDPLLVGPGDDCAVFAGSPTPTVLTTDTLVEGKDFLDPWPAGISSGGYEVGYKAATQNLADIAAMGAEPVTLVVSLSMPAHTTYGWVEDFARGITDSIVACGAHSCTVSGGDLGTSNDITVSITAMGRMHPDTPKPVLRSGAQAGDTVAFAGQVGWADAGLRLLLQSHNPYLADIMAKQTTGKHPRCDDKVVQRALTAQLRPTSPVPAGVLAARAGATAMLDVSDGLLKDAERIACASAVDISLSAEAIEALSKPLVPLAQAILHGQPRNEDADSYVSLAQECVLGGGEDHGLLACFPSGALLPEGFVALGSCLVPEGQQPRVLLGQRQAQARGWEHYQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R154</accession>
    <name>A0A2Z5R154_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">23S rRNA (Uracil-5-)-methyltransferase RumA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88477">
        <property type="protein sequence ID" value="BAV88477"/>
        <property type="gene ID" value="RA11412_2178"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2178"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="218" mass="24000" checksum="21835612977C113D" modified="2018-10-10" version="1">MRLTCESPAHGGAFVARSEKGVVFVRHALTGETVQARITDIGPKNRYYFADAVAIDTPSPARREHPWVQGNSLLTDEERAAATGVKELLGGMEYGHIDPATQRAYKTDTLRTQLIRLGGISPDSPLITSLTVEPMPTKDLTEGDLSWRSRVRYTVVKTPSGWRIGMYPHQSSRAVPVIDFPLAARELRQLNLHELDLHGIRQVDAALSSRAVSSFSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R161</accession>
    <name>A0A2Z5R161_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88525">
        <property type="protein sequence ID" value="BAV88525"/>
        <property type="gene ID" value="RA11412_2226"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2226"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015315">
        <property type="entry name" value="DUF1963"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035948">
        <property type="entry name" value="YwqG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09234">
        <property type="entry name" value="DUF1963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103032">
        <property type="entry name" value="SSF103032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="333" mass="37835" checksum="E25070FAB0845064" modified="2018-10-10" version="1">MCFISHGGNCGEIYTRNSQTVTCSTQTCSNGVWAYGAEIFQDRVWGIEEYMTNKQAEILERARALLAEMNVGHQVPTMRINTQFAKYKTLPVTASKIGGVPYLPKGQDGPVDVNGEPLHMIAQINCADLPPNSIYPAEGLLQFWISPTETDTEDYTSSRYDRVIYYPKLGKANRKAHKLVITEDNGFIWPLLGGEYALSFEPENLEPGLKLKQYSTGQLFTRLWNERYPQEQIESPWDLDELAGIEGDDLASTFYEDLDHHQLGGVPEYIDWDPRDDNEEWKDYTINLLTLVSADDDTITIMWGDAGVANWLITPEQLKNLDFSKVFYSWDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R164</accession>
    <name>A0A2Z5R164_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ArsR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88231">
        <property type="protein sequence ID" value="BAV88231"/>
        <property type="gene ID" value="RA11412_1932"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1932"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="82" mass="8929" checksum="9D94CA94BE97E036" modified="2018-10-10" version="1">MENGSAHKDWEHEFGASVAIFSALAHPLRLAIAHHLVERPHSVSELHSCLGISQPLASHHLRILREAHVVEGSSRAGPPYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R165</accession>
    <name>A0A2Z5R165_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">dnaJ</name>
        <name evidence="12" type="synonym">dnaJ_2</name>
        <name evidence="11" type="ORF">I6I94_00315</name>
        <name evidence="12" type="ORF">NCTC10207_01240</name>
        <name evidence="10" type="ORF">RA11412_1947</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887358.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88246">
        <property type="protein sequence ID" value="BAV88246"/>
        <property type="gene ID" value="RA11412_1947"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1947"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="130"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="143"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="160"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="186"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="200"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="130"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VEI23143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="376" mass="40619" checksum="73038A1517323FE0" modified="2018-10-10" version="1">MSDHYATLGVSKDASPEEIKKAYRKKARQLHPDVNPSADAAEEFKRVTLAYEVLSDTEKRRIYDATGDEQGRAGGFGGAGFGGFGGAGFGFQDLFDMFTGGQQSGPASRVRQGQDSLINVSISLRDAVFGVEKTIDLKTAVTCQSCQGEGTAPDTHPETCDTCHGAGYMQRRVQSILGTVMQQVECPTCHGYGTVIKHPCAECSGKGRVRANEPVTFTVPAGVNDGARIRLRGKGEAGLNGGPNGDLYIDLRIKSDKYFNREGDDLLTTVNVPMVAAALGTVIPLETFDGQQQVNIPAGSQSGDTVTLPGLGAARLHEDRRGDLRVRIQVTTPTNLNEEQRTMLRQFAELRGENLQEGSHVKQKHGLFSKLKEQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R166</accession>
    <name>A0A2Z5R166_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutaminase</fullName>
            <ecNumber evidence="3">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1991</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88290">
        <property type="protein sequence ID" value="BAV88290"/>
        <property type="gene ID" value="RA11412_1991"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1991"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="PTHR12544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="128" mass="13464" checksum="DE7E918F6F0AA751" modified="2018-10-10" version="1">MRSPIPSYLDDVLATVASDKTGELANYIPELAGVNPDRLGASIAMVDGELYGAGDVNEVFTIQSISKPFVYALALADRGFDKVLAKVGVEPSGEPFNEISLEDESGRPLNPMINAGAITTHSLVGAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R180</accession>
    <name>A0A2Z5R180_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_00255</name>
        <name evidence="1" type="ORF">RA11412_1967</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88266">
        <property type="protein sequence ID" value="BAV88266"/>
        <property type="gene ID" value="RA11412_1967"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1967"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="340" mass="37339" checksum="1567D86364A9AE5B" modified="2018-10-10" version="1">MNAAHARGAVTTRDRARHMIAAQLEADFCLPHGSVAKAHGQGAELLAQLQLPADKMGSSRRRNDDIWELRVANYAGVGLLCAKHPRVLEKAREYMAGDNPNWLGYYAQLRQLNELLTPYSQQVSGTSIYYTPTRALLESVVPENLPAQEVKCAVPGIGMMRRVDSASLRHALYDQVTGEHTIVTAPNASAAAIETSPEDTAGTKLPVRFEFLTPQQCERFRGDTRYANALGFSCRRPDVTVLAAYGVETEATDPIALVGASDDSPLMRQIGVDVLPEFRHYGLASRMIREVTRIVLAEGYLPFYGTSPSHILSQRTAAAAGLTPTWWEFVSTSLHDMQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1B3</accession>
    <name>A0A2Z5R1B3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Probable siderophore transport system ATP-binding protein YusV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yusV</name>
        <name evidence="6" type="ORF">NCTC10207_01400</name>
        <name evidence="5" type="ORF">RA11412_2144</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">NCTC10207</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88443">
        <property type="protein sequence ID" value="BAV88443"/>
        <property type="gene ID" value="RA11412_2144"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2144"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VEI23299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <sequence length="283" mass="30503" checksum="591EAAF7D8071249" modified="2018-10-10" version="1">MSAQTMNSTARLQGSGLVVGYGEHKVLDGVDFSVLEGELTVILGPNACGKSTLLKTLSRVIPFKGGQVHLDGQPLSGLKSRAIARILSMLPQTPEAPSGVTVADVVARGRYPHQSLLRSWSAQDEAACIEAMEAANVLELSERPIEALSGGQRQRVWIAMTLAQQTPLILLDEPTTYLDITHQIEVLNLTKKLHRQGRTVAVVLHDLNLAFRYATHVVLMKRGQIIAQGNPKKIVTSGLIREVFDLEAVIIDDPCTGTPLVIPTEQQNISIAADAIAAAREGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1C8</accession>
    <name>A0A2Z5R1C8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="6">2.2.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">RA11412_2173</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88472">
        <property type="protein sequence ID" value="BAV88472"/>
        <property type="gene ID" value="RA11412_2173"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2173"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="11">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Transketolase_C" evidence="12">
        <location>
            <begin position="117"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV88472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="261" mass="28188" checksum="638A8BA6B4173FC6" modified="2018-10-10" version="1">MALYATFLNRGFDQLLMDVALHKAGVTLVLDRSGITGPDGASHHGMWDLALLQFIPGLYMAAPRDAATLREALREAVAIDDAPTVIRYPKGSVGEDIPALERREDGVDVLVRTGAAHPQTGQRDVLFVAVGAMVRVALEVSQILETHRVHSTVVDPRWVMPVPASVVELTRDHRIVVTIEDGVRSGGVGARIRQEMRAAGVDTALSELGLPAEFIPHASREEILEETGLSAETIAADVLAQLAGDKVPFAREEGQKPRHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1D5</accession>
    <name>A0A2Z5R1D5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA (Guanine37-N1)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_2061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88360">
        <property type="protein sequence ID" value="BAV88360"/>
        <property type="gene ID" value="RA11412_2061"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2061"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="5">
        <location>
            <begin position="22"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="194" mass="20631" checksum="C7976CBB3736B40F" modified="2018-10-10" version="1">MRFDVLSIFPEYLAPLELSLIGKAREDGLLSLNTVNLRDYTFDRHRTVDDTPYGGGAGMVMKPEPWGLALDAVLASSPHQSNEPAPADTAGAAVEGTPGTEDASGSDEVPLLPAPQHVPEPDGRPLLVVPSPAGAVFNQEMAYEFAAEQHIVLRADGMRGLTSGCCCGRVSVSVLCPSLLATMCSTVVRLRSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1F0</accession>
    <name>A0A2Z5R1F0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Energy-coupling factor transporter transmembrane protein EcfT</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Transmembrane component BL0694</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_00030</name>
        <name evidence="6" type="ORF">RA11412_2022</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88321">
        <property type="protein sequence ID" value="BAV88321"/>
        <property type="gene ID" value="RA11412_2022"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2022"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="270" mass="29687" checksum="02DC75219887993F" modified="2018-10-10" version="1">MEDSGFLELPELSVGAARGTQQSQIQPEGVSAHGDGKLDPRSLILLTFFTNIIAINSSATWLILLCIITTALFSLCALPWRLFMWWAGFELLCVICAFVPPVIAPSHVSVAVGVSAFWFMKFNITAAFGIMFFTAITPHQVSAVLTRLRVPVFIYVPIMVMYRFFPIARDELSSTQEAMVLRGLQPGLRAMILHPLRHLELILIPFLLSATRIVDELSAAALLKAVGVGKSAERAPRTTVIPTRFTRYDALAIGLCIMLVAAEGVQLWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1F2</accession>
    <name>A0A2Z5R1F2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_10395</name>
        <name evidence="5" type="ORF">NCTC10207_01520</name>
        <name evidence="3" type="ORF">RA11412_2268</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88567">
        <property type="protein sequence ID" value="BAV88567"/>
        <property type="gene ID" value="RA11412_2268"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2268"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI23413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="189" mass="20278" checksum="A6AD954DFC2737ED" modified="2018-10-10" version="1">MEPTPNTQHPYAQPSSPMQPVPPLAQLSPQTVHPQAAPTVAGISALDYDFNYNRMPAEYEVPDEYRRPYGRAPGDIRGPGYFYAVGGFALALFSLVYSGVQSLTTLSRAASMYRPYEIVQVTNVLMGGLLPALMAFILGIYAFKVSGKTKTKTSASSRTTTFGSLAIVLGGLSILGLIGSAVLYVLAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1I2</accession>
    <name>A0A2Z5R1I2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_11225</name>
        <name evidence="2" type="ORF">RA11412_2055</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88354">
        <property type="protein sequence ID" value="BAV88354"/>
        <property type="gene ID" value="RA11412_2055"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2055"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="98" mass="11134" checksum="E33F4881CD15BBAF" modified="2018-10-10" version="1">MAVVKINKLSVQEGMGEELERRFKNNNEKLSEVPGFLSFELLRPTSGGTEYFAMTHWQDEESFRNWLANRHVVRDKPVVSASEGILGFEVVDFEAISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1J1</accession>
    <name>A0A2Z5R1J1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88386">
        <property type="protein sequence ID" value="BAV88386"/>
        <property type="gene ID" value="RA11412_2087"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2087"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="57" mass="5940" checksum="FD179A5AA8B78961" modified="2018-10-10" version="1">MSRIIAGAAGGLRLASVPGDTTRPTTDRVKESLFSKLESYGVLEGARVLDVYGGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1J4</accession>
    <name>A0A2Z5R1J4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88420">
        <property type="protein sequence ID" value="BAV88420"/>
        <property type="gene ID" value="RA11412_2121"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2121"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="80" mass="9026" checksum="4E5C786078B51841" modified="2018-10-10" version="1">MDDMPFEGPKDNTYVWTIKFETDSAARLYDKTSHQSVNFNSLNGTDTENKGYFEYANGKWKILSSSSLPSSWSPGKTASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1K0</accession>
    <name>A0A2Z5R1K0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-[ACP] synthase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88374">
        <property type="protein sequence ID" value="BAV88374"/>
        <property type="gene ID" value="RA11412_2075"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2075"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="2">
        <location>
            <begin position="146"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="1">
        <location>
            <begin position="281"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="366" mass="39308" checksum="D4AE74EEDE631F21" modified="2018-10-10" version="1">MNEIVLSKTYEGIMSAQNAASPGSEANSDIRHRNAALLSIENELPPLVVSSDYFDEQLADTYKRLRMPKGLLERLAGISERRGWAQGQTFEDGAVAAAEKAISSAGIDRNRIGLMINASVTRDNFEPAVSVGVHDRLNLPRHALNFDITNACLGFVNAMTVAATMIDSGAIEYALVVAGEDPSPWHRTALRILNQPNTSRDDVLAQFATLTLGSGAAAAVIGRADEHPNGHRIVGSVSRAGTEHRDLCIGGEADQGMNTDAAGLLEHGLELVAQAWEQAHQDGWDWGSMTSYVTHQVSNAHTNAIIEAVGIERERIPLTFPRWGNVAAAALPMTLAEYAPTYAKGDRILCMGVGSGLNTALMEITW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1K8</accession>
    <name>A0A2Z5R1K8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,3-dihydroxybenzoate-AMP ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88440">
        <property type="protein sequence ID" value="BAV88440"/>
        <property type="gene ID" value="RA11412_2141"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2141"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="44"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="563" mass="61072" checksum="AA27EC8B3DB3D1D0" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1L0</accession>
    <name>A0A2Z5R1L0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable membrane protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">RDD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NCTC10207_01499</name>
        <name evidence="8" type="ORF">RA11412_2244</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">NCTC10207</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88543">
        <property type="protein sequence ID" value="BAV88543"/>
        <property type="gene ID" value="RA11412_2244"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2244"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="68"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VEI23392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <sequence length="147" mass="16259" checksum="A4236B86326F2FBD" modified="2018-10-10" version="1">MKSMIEREDLGSWLNGAPSNQKYPGEHLGRPQKGPGAIARPGIRLIGFLIDWYVCYLPILLFADNDPLLTLLVFWGYTVLLTGFMGHTLGHLAVGVQVQTLNGRPAGWLKGLIRGTLTMLILPAVIMDSDARGIHDRICKTVLVRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1M9</accession>
    <name>A0A2Z5R1M9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88414">
        <property type="protein sequence ID" value="BAV88414"/>
        <property type="gene ID" value="RA11412_2115"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2115"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="59" mass="6202" checksum="781761112CE77919" modified="2018-10-10" version="1">MVLSAAEGFSARAGLAGADTIAPEHPLVKRTLATENMPKTVRRVMEEANAAILSGLNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1R1</accession>
    <name>A0A2Z5R1R1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_10175</name>
        <name evidence="7" type="ORF">RA11412_2314</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88613">
        <property type="protein sequence ID" value="BAV88613"/>
        <property type="gene ID" value="RA11412_2314"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2314"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033776864" evidence="5">
        <location>
            <begin position="21"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="6">
        <location>
            <begin position="32"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="286"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT90156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="658" mass="70253" checksum="019E7F7B0352F5BF" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1S1</accession>
    <name>A0A2Z5R1S1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">hemL</name>
        <name evidence="10" type="ORF">I6I94_10040</name>
        <name evidence="9" type="ORF">RA11412_2349</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88648">
        <property type="protein sequence ID" value="BAV88648"/>
        <property type="gene ID" value="RA11412_2349"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2349"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT88850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="449" mass="46776" checksum="57622B8C8A50E0EF" modified="2018-10-10" version="1">MSVSAEHHLAHQHSEELFERSRSVIPGGVNSPVRAFNSVGGTPAFVTRASGPYIYDADGNEYVDLVCSWGPAILGHAHPQVVAAVQEAASRGLSFGAASAPEAELAELVVDRVNTAIPGAIEQVRMVSTGTEATMTAIRLARGITGRDKIIKFSGCYHGHVDALLSEAGSGVATLALPGSAGVTAATASETIVLPYNDLDAVREAFAAHPGEIAAIITEAAPCNMGVVTPEPGFNRGLREMTQSNNALLIFDEVLTGFRVSSAGYWGKFAPEDNGWVPDIFTFGKVIGGGMPIAALAGKREVMEHLAPTGPVYQAGTLSGNPLSVASGITTLKLADDTLYRTLDTRSEQLQAALTQALADAGVDHSIQTAGNLFSVAFGTGEHGVRNYADIKGSATAKYTAFFHAMLDAGVYLPPSAFEAWFLSGAHDDTAMERIIEALPGAARAAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1W3</accession>
    <name>A0A2Z5R1W3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09845</name>
        <name evidence="2" type="ORF">RA11412_2399</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88698">
        <property type="protein sequence ID" value="BAV88698"/>
        <property type="gene ID" value="RA11412_2399"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2399"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="139" mass="15658" checksum="D80E42382BBFA62B" modified="2018-10-10" version="1">MARTHRHKEEPVFLLQDTPDALREIGVDDEQEALAAVREPAQALEGASFLQAVGRFYRFYTLGRGHASRSEVLWALLYLTLTTGAVLGLTVYLGMLSEDPHMESLIRVLYMLMMTLTPVWIIVHILPLSSLLSRARGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1X3</accession>
    <name>A0A2Z5R1X3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6318 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88570">
        <property type="protein sequence ID" value="BAV88570"/>
        <property type="gene ID" value="RA11412_2271"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2271"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046281">
        <property type="entry name" value="DUF6318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19843">
        <property type="entry name" value="DUF6318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6318" evidence="1">
        <location>
            <begin position="5"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="138" mass="16135" checksum="5B5C9BA1FA129CBB" modified="2018-10-10" version="1">MPEDGYKLATVEGLEKSVHAWVNWKNYGIQTGDYTIARQFVSAQFTEETEYMDTITKLYERGGWVKGGVAYFEFHGEPIIKDDGVYQWEFYRLWKEIMQIEPNGRYRKSKNTPSTNNLYWLQAKNDGSSWKILSIKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Z2</accession>
    <name>A0A2Z5R1Z2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_09725</name>
        <name evidence="1" type="ORF">RA11412_2429</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887450.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88728">
        <property type="protein sequence ID" value="BAV88728"/>
        <property type="gene ID" value="RA11412_2429"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2429"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="486" mass="55569" checksum="103C4A4BE2E0BB16" modified="2018-10-10" version="1">MPDPRETAPNERIIFTAEADADHIEKNLRLTEEQLKQPKNAALYLSSVTAVYDAQAEPNRNWECVYRYSAGETLDAIATDIGVTRERVRQIINAAHTHISVPQLKVARRTVKEQEQEDLRHMVYEWSVHNPDRAGQECEEEFGVTRQQVKRILKGRAALHYPVEPRAQGDEQKEWQDQQLIDLLRQWWDECTDHRSMSFNDWSVARGGPTRQTPIIRFGKWSHALAAAGLGDERSRPRRRRGKYGEADLWAALVQFVSTPRQKYTYLEFEEYARSVPGMPSAVLVRKYLNKNWNTQVEIAKTIMRGNYESLPPEVIAAGVENIRRERNWEQEYARSKDNEQESVQVAVDALKQYIAHHGSRVVNARYDEWAHGQGLPLGVTLTKKSGLKWAELVQRAGGTCGTRAPRNLSPDEVQARNERALAGIREYLEHEAGTPTYDRYIAWAQQAGEEYPKGTALHSWFGGWRNALQQARRSSAGTQTETPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R291</accession>
    <name>A0A2Z5R291_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coproporphyrin III ferrochelatase</fullName>
            <ecNumber evidence="7">4.99.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cpfC</name>
        <name evidence="9" type="ORF">RA11412_2355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.9" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88654">
        <property type="protein sequence ID" value="BAV88654"/>
        <property type="gene ID" value="RA11412_2355"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2355"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="466" mass="50232" checksum="D8E5EB7FD62980DF" modified="2018-10-10" version="1">MNQPVTNHAARPGAGGSGVCSGCCGSVPNNIRPNVTDPHNTASNGPAVLNEDTIGSYRGECGITRSRAAAPAPYDLVILSSFGGPEGQDDVIPFLRNVTAGRGIPDERLEEVATHYRANGGVSPINEQNRALLAALKQALAERGPRIPIVWANRNWDPYVSDVLQQAYEEGHRNILVLATSAYPGYSSCRQYREDYGVALQKLGLHGQMRVDKIRQFFDTPGFVQAFADGLQDGLKQVQEQVAARRADGTAAAGNGRIRIMFCTHSVPTSAANEAGPRGIDYEGGSAYVEKHLQVARAVLARVQEHHESLLDNTDWELVYQSRSGPPSMPWLEPDVNDAIEKAAGDIDGIVLVPLGFVSDHMEVKWDLDTEALDTCAEHGIAAVRTPTPGTHPAYVESLRRLIAERVAANPHTGLDHEAARTRESVCEESVTGERGWFDECDPDCCKPARGAAKPVIAEYSGGTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R297</accession>
    <name>A0A2Z5R297_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">rplO</name>
        <name evidence="11" type="ORF">I6I94_09195</name>
        <name evidence="10" type="ORF">RA11412_2549</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88848">
        <property type="protein sequence ID" value="BAV88848"/>
        <property type="gene ID" value="RA11412_2549"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2549"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="30"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT88688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="148" mass="15738" checksum="21E7BF197DB2C19F" modified="2018-10-10" version="1">MADAIKIHDLRPAPGAHKAKTRVGRGEGSKGKTAGRGTKGTKARYQVRAGFEGGQLPLHMRLPKLRGFKNPFRTEYQVVNLDRIQELFPSGGDVTIAELVAKGAVRKNQPVKVLGNGEITVKVNVTVDKASASAIEKIKAAGGSVTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2A8</accession>
    <name>A0A2Z5R2A8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_0730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87029">
        <property type="protein sequence ID" value="BAV87029"/>
        <property type="gene ID" value="RA11412_0730"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0730"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="211" mass="22576" checksum="9FEF7E24371404E4" modified="2018-10-10" version="1">MKQTQQAEKPRTHPAWLIIISLSIPMFMASLDNLVVTNALPVIRADLGATLEELTWTVNAYTLTFASCILMSSALADRFGRRSVFLLGVFIFTASSAWCGISDNIGALITARTLQGIGGSAVMPLSLALLSTSVPERLRATAIGIWGGVAGLGVALGPLIGGAVVEGMNWHAIFWINVPFGLLCIPWYGPRSRNPAVAPNRLIFLGWPSWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2D5</accession>
    <name>A0A2Z5R2D5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xseB</name>
        <name evidence="6" type="ORF">I6I94_09555</name>
        <name evidence="7" type="ORF">NCTC10207_01682</name>
        <name evidence="5" type="ORF">RA11412_2463</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88762">
        <property type="protein sequence ID" value="BAV88762"/>
        <property type="gene ID" value="RA11412_2463"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2463"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VEI23698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="89" mass="9896" checksum="B7C5302D9DB1544F" modified="2018-10-10" version="1">MAENISFNTESLGAPVDTLSYEQARAELENVVRQLESGASDLETSIALWERGESLAKRCEAWLEGAREKLNEARAEQREDAEDGEETHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2F0</accession>
    <name>A0A2Z5R2F0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_10020</name>
        <name evidence="1" type="ORF">RA11412_2352</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88651">
        <property type="protein sequence ID" value="BAV88651"/>
        <property type="gene ID" value="RA11412_2352"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2352"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="171" mass="20018" checksum="03E8D49E30A312BE" modified="2018-10-10" version="1">MLNGWDEQLAQCCQRRTDKITLPGKLPAGLDGAYLRFLAQYRGGEITADCCLYGYEQALEHHRYLEREHPEFSRTVWPVGSAGNGDEWFFARDSNTILYYDHDAGQYDAQHVEDMRISFTEFVELHFLYRELEDYLDRRGSLTDTQRQDFVRSVNAIRDGLFEDYPFAPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2P5</accession>
    <name>A0A2Z5R2P5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88882">
        <property type="protein sequence ID" value="BAV88882"/>
        <property type="gene ID" value="RA11412_2583"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2583"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="3965" checksum="A7D50A68DD60EAF8" modified="2018-10-10" version="1">MRLRGENISRTTMVSNHTGFKAVVAFLAVKPAGLSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Q5</accession>
    <name>A0A2Z5R2Q5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyphosphate kinase 2</fullName>
            <ecNumber evidence="6">2.7.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppk2</name>
        <name evidence="6" type="ORF">I6I94_09265</name>
        <name evidence="7" type="ORF">NCTC10207_01748</name>
        <name evidence="5" type="ORF">RA11412_2531</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037234584.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88830">
        <property type="protein sequence ID" value="BAV88830"/>
        <property type="gene ID" value="RA11412_2531"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2531"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022486">
        <property type="entry name" value="PPK2_PA0141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03707">
        <property type="entry name" value="PPK2_P_aer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="4">
        <location>
            <begin position="101"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VEI23818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="359" mass="40974" checksum="1A6667562DBA998C" modified="2018-10-10" version="1">MTEKNPATEQATTVEAQSVTAHSVSEKAVFETEKSGASTSDKRAAIKQALRPQLRRTSVVEDYAAELDEMASLTHALNGSKKDDNKSDAWKIGYPYDTKLGRKAYEKEKRALQIELLKLQLWAKATGQKILIIFEGRDAAGKGGSIKRFTEHLNPRGARVVALEKPTDIEQTQWYFQRYIKHLPSGGEIVMMDRSWYNRAGVERVMGYCTQTQYFEFMREVPDLERMLVNSGIKLIKFWFSVTKQEQLARFNSRRTDPVRQWKLSPTDLASLDKWDDYTAAKEAMFFYTHTGDAPWTVIKSNDKKRARLEAMRYVLSQFDYPSKDHEVVGTCDPLIVRSATDVFEEEGGSDPEGFPVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2V5</accession>
    <name>A0A2Z5R2V5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">guaA</name>
        <name evidence="12" type="ORF">RA11412_2497</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88796">
        <property type="protein sequence ID" value="BAV88796"/>
        <property type="gene ID" value="RA11412_2497"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2497"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="206"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="233"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV88796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="535" mass="57756" checksum="76B05BC659800EC7" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2X4</accession>
    <name>A0A2Z5R2X4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88816">
        <property type="protein sequence ID" value="BAV88816"/>
        <property type="gene ID" value="RA11412_2517"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2517"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="79" mass="8306" checksum="C00A3E2B5B917F23" modified="2018-10-10" version="1">MPLGDLLGGVRRCLYILSWTPPAVIRPSHRVFRVFLPCGVSSIMHNAAGRSVSAGCALAMCRYAVLGAGVFWGGCGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R301</accession>
    <name>A0A2Z5R301_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adk</name>
        <name evidence="9" type="ORF">RA11412_2547</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88846">
        <property type="protein sequence ID" value="BAV88846"/>
        <property type="gene ID" value="RA11412_2547"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2547"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="4"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="51"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="79"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="180" mass="19857" checksum="61AF07F696FA3900" modified="2018-10-10" version="1">MAPGAGKGTQAVKIAEKLNIPAISTGDIFRKNIKEETDLGKEAKSYIDSGNLVPDSVTNRMVRARLAEADTANGFLLDGYPRNTAQVHELDSILAETHQQIDRVLLLVADNDELVARLLNRAAEQGRTDDNEEVIRHRLKVYEEETAPLIAIYRERGIVKEVNGLGEIAEVTERILSALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R314</accession>
    <name>A0A2Z5R314_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_08785</name>
        <name evidence="1" type="ORF">RA11412_2651</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88950">
        <property type="protein sequence ID" value="BAV88950"/>
        <property type="gene ID" value="RA11412_2651"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2651"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="305" mass="34537" checksum="81414229DEF6F54F" modified="2018-10-10" version="1">MTDDLFLTEFIPWPVPAGWVQRQQQFKHPAARLIPGELHIPFAWEEGVESGEKGCILRYQVVWEGLTPDMFENGNRWGFPYRAGYLSVFPFSQAADDGLIFGMDITETELHLTAEQDNYFWSPQEGPDYEEWAKTSLLARVRIGEDMTPVWEVHDTNPYRRRYLENVLGALVESLSLTPVELAEGEAHLVEDSEYDWGGPVGSLHYATTLVADRFSEGGCTRVEKPQMLRLVACMHPIGIGAPDPVYVAQFFNTAEPEYLAWSTGEDARYWPKELSPAAFPPLTGEDLPEHIRQLIAHLPLVQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R335</accession>
    <name>A0A2Z5R335_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89062">
        <property type="protein sequence ID" value="BAV89062"/>
        <property type="gene ID" value="RA11412_2763"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2763"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd14951">
        <property type="entry name" value="NHL-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045302">
        <property type="entry name" value="NHL2_NHL_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="584" mass="62514" checksum="ACEF5EF37A4D8A0A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3B2</accession>
    <name>A0A2Z5R3B2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamin-phosphate pyrophosphorylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Thiamine phosphate synthase</fullName>
            <ecNumber evidence="4">2.5.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_08375</name>
        <name evidence="3" type="ORF">RA11412_2747</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89046">
        <property type="protein sequence ID" value="BAV89046"/>
        <property type="gene ID" value="RA11412_2747"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2747"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="2">
        <location>
            <begin position="18"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV89046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT88539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="204" mass="21994" checksum="75455EF31302EA5B" modified="2018-10-10" version="1">MTTNSTAETAIPLDLSLYLVTGENPVETVRRARHATCIQVRSKPISARDLHALAEEIARIALPHQKILIDDRVDVALALRARGVRIDGVHIGQDDLPVADARRLLGEHAIIGLTTGTRELVERANTVAHLIDYIGAGPFRPSPTKASNRPPLGIEGLHELAELSKIPVVAIGDIWPQDCPSIRETGVAGVAMARAFVENPELQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3P2</accession>
    <name>A0A2Z5R3P2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87729">
        <property type="protein sequence ID" value="BAV87729"/>
        <property type="gene ID" value="RA11412_1430"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1430"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="82" mass="9234" checksum="2C884238AB3FEDE9" modified="2018-10-10" version="1">MGALQALKRKLQDGERDSEKLGEACDRIVAATQKVISESGEEGEAIAELLRDSVSDTVYFFLEEHNLDDDFDIRAFVTARNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R446</accession>
    <name>A0A2Z5R446_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutaminase</fullName>
            <ecNumber evidence="3">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_1990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88289">
        <property type="protein sequence ID" value="BAV88289"/>
        <property type="gene ID" value="RA11412_1990"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1990"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="PTHR12544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="5">
        <location>
            <begin position="196"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="291" mass="31728" checksum="C8A107B64288E9E7" modified="2018-10-10" version="1">MERVIEGLSAFAGRPLQIDEAVYSSEIEHAHRNLAIAHMLRSHDILTENPAKVVEGYTRQCSLEVTVKDLAMMAATLANYGEQPLTGEQVVPKTVVRQVLSVMFTCGMYNAAGDWATQVGIPAKSGVGGGIIGAVPGQLGVATFSPRLDIHGNSVRGVSLFERFSSDMGMHVMNIPTVARSAIRANYRVGVGAETVQVIQLQGRIRFAGAERVIREIVDTEYTGTKIALDVTRVYSVDDVAQHMLLEIMRRLTIDGYTVYLIDQDDTLPDVEALRKMQVAVLESVDEIGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4U8</accession>
    <name>A0A2Z5R4U8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">rpsG</name>
        <name evidence="11" type="ORF">I6I94_09065</name>
        <name evidence="12" type="ORF">NCTC10207_01788</name>
        <name evidence="10" type="ORF">RA11412_2580</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887788.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88879">
        <property type="protein sequence ID" value="BAV88879"/>
        <property type="gene ID" value="RA11412_2580"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2580"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV88879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT88662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VEI23889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="156" mass="17382" checksum="025D939186889831" modified="2018-10-10" version="1">MPRKGPAPKRPLVNDPVYGSTLVTQLINKVLLDGKKSVAQRIVYGALEGVEKKTGSDPVVTLKKAMDNIKPSLEVRSRRVGGATYQVPVEVRPGRSTALALRWLVGFSKQRREKTMTERLMNEILDASNGLGAAVKRREDTHKMAESNKAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4Y4</accession>
    <name>A0A2Z5R4Y4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0234 protein RA11412_2670</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0234 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88969">
        <property type="protein sequence ID" value="BAV88969"/>
        <property type="gene ID" value="RA11412_2670"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2670"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="184" mass="20539" checksum="CAA8D64D06B52E54" modified="2018-10-10" version="1">MCTRCALARRTPLPTERNRKPMASESSFDIVSKVDKQEVANALHQAQKEVSQRYDFRNVGAEIDFSGEKILIKANTEERALAVLDVFQSKLVKRGISLKSLDDGKPYASGKETRIECAIKEGIAQDQAKKISKLIRDEGPKGVKATIQGDELRVSSKSRDDLQDVIAMLKAADLEVDLQFVNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVB2</accession>
    <name>A0A2Z5QVB2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86320">
        <property type="protein sequence ID" value="BAV86320"/>
        <property type="gene ID" value="RA11412_0021"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0021"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="78" mass="8478" checksum="8C66DA73BF4AA5D9" modified="2018-10-10" version="1">MSVRGTTDRIEAENTQFKARTHTAFTDLAHAETTGPHTVIDGSGTIEQVHERVLAAITPLLAQRSLPRENTAPTKEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVD0</accession>
    <name>A0A2Z5QVD0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_07965</name>
        <name evidence="4" type="ORF">RA11412_0048</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86347">
        <property type="protein sequence ID" value="BAV86347"/>
        <property type="gene ID" value="RA11412_0048"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0048"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="212" mass="23606" checksum="979F13834434CA94" modified="2018-10-10" version="1">MEHYIRNEAEMSQDAPNHTKNKTRKLPVPHRTRLTPAAREEQIINVAAAHFARRGVVGASMLDIAKEAGITRALLYHYFPGKESLAAAVTRREARAVLETLSEHHEDPQEALHTALHVYFDRVAGRGTEATSAVPDTPDEYLEWMLHRTGMPVNDRTRMILGGWMHLVDYFARHVVQGKARGRVSAGARAMRTEEAIELCMGAADNLTGGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVI1</accession>
    <name>A0A2Z5QVI1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86314">
        <property type="protein sequence ID" value="BAV86314"/>
        <property type="gene ID" value="RA11412_0015"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0015"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="38" mass="4165" checksum="436F7FE472D15DE3" modified="2018-10-10" version="1">MAGAEGGMMSSMLLFELIAITIAMVFLTNVHPSVRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVJ7</accession>
    <name>A0A2Z5QVJ7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SagA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86418">
        <property type="protein sequence ID" value="BAV86418"/>
        <property type="gene ID" value="RA11412_0119"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0119"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016403814" evidence="2">
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            <begin position="31"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="104" mass="11027" checksum="65D509620B18ED4C" modified="2018-10-10" version="1">MAKKIVRNAGIVAFAGAALVGSTVPANAFAQVPAAADLSYDYNNYETDYTSYQTGATNYVAPQAEYQTEYVAPTPSFGQQQTTNTSSTTPPLLCRPQPVATRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVK1</accession>
    <name>A0A2Z5QVK1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable transcriptional regulatory protein TcrX</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Response regulator receiver</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Response regulator transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tcrX_2</name>
        <name evidence="6" type="ORF">I6I94_07675</name>
        <name evidence="7" type="ORF">NCTC10207_02087</name>
        <name evidence="5" type="ORF">RA11412_0124</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI24449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887005.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86423">
        <property type="protein sequence ID" value="BAV86423"/>
        <property type="gene ID" value="RA11412_0124"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0124"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="131"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="131"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV86423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT88412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VEI24449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="234" mass="26395" checksum="D49511B05641A300" modified="2018-10-10" version="1">MSAEAKLLVVDDEFNILELLATSLRFAGFEVVTAGNGREAIEKAEQEQPDLIVLDVMMPGMDGFDVTRRLREGGRTYPVLFLTAKDATEDKVAGLSAGGDDYVTKPFSLDEVIARIRAILRRSRSLQEEDTAILRVDDLSLNTDTHEVFLGEEEIDLSPTEFNLLHYLMLNANRVLSKAQILDHVWEYDFNGDSSIVESYISYLRRKIDNNREGHEPLIHTKRGVGYMVRGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVL9</accession>
    <name>A0A2Z5QVL9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ACPS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86432">
        <property type="protein sequence ID" value="BAV86432"/>
        <property type="gene ID" value="RA11412_0133"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0133"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="224" mass="24121" checksum="C53C136D3E053BBE" modified="2018-10-10" version="1">MSQVSSLAVGGFCPDDTQVLGVDLEPRRDRLFPGFARVALSLREREIYETTTGEARNLLGVALWTAKEAVLKATGHGLSVSPAAVRVFFSDSLTDQLAEAFEASRESADEEVTAASVCSARAVFTVPSRDNSDTTEERSFYITWTALTLHPEKQPAHNNPQNTNPAHGSDVAAEQFLLATATEGVPNSVHVHPVATPVELRNNLAPLTFSQLPTMRMGTNTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVP3</accession>
    <name>A0A2Z5QVP3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_0147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86446">
        <property type="protein sequence ID" value="BAV86446"/>
        <property type="gene ID" value="RA11412_0147"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0147"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="250"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="453" mass="47785" checksum="FFAF8BB8B9E476EF" modified="2018-10-10" version="1">MRRTTELSPEHPESPAPRIPTNTPDSTAKPTSATPLNARGQLTLLTAQVSDALASSIQAIAMPLLTYGATGDLAHSAIVMVVEAVPVILFAPFAGTIADRFNRKTLTVSFRLASAALLIASPALYAAAGLSAFLTIAFLVSTFGTFSSPAASAAMPSLLGDDYQKYMARRGSLIFLAQTLGPTIAAAVASFTTPALAVGFAGTLNLLAALTVATIRNYDLTHAERTATVQEHHTGRLLREGAAYTAHNPVVRGMLTFWFLSIAAVPITTLPMLEYLTRGLGHDYTAFGIATSVYAAGCVISSWLSAKLGVGTGTGRVRITKRGWMCISGLGYGAVCLSMGLYPALWAVLVLWFTWGMFYGPEEVLGQVLFADAIDEHMRGRVYSFMGVVFSLAGMVGYLITGWAVPAFGAINTIVAGGSLFVIATVFTFILGPTARAIRAQESRNEAKNRAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVR5</accession>
    <name>A0A2Z5QVR5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86471">
        <property type="protein sequence ID" value="BAV86471"/>
        <property type="gene ID" value="RA11412_0172"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0172"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="39" mass="4282" checksum="25423009EC81E02B" modified="2018-10-10" version="1">MPLGDDIFAFCTGVFGGISSLGWRRRGGVLTLRYDVGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVW1</accession>
    <name>A0A2Z5QVW1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_0227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86526">
        <property type="protein sequence ID" value="BAV86526"/>
        <property type="gene ID" value="RA11412_0227"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0227"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="65" mass="7097" checksum="2797611E0CFB6397" modified="2018-10-10" version="1">MWHSALLGAVLLVVAGYAAMRVLAPFQIPVGLATGAVGGVYMLWLLRKVRWFTHPLRLCVGEMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVW5</accession>
    <name>A0A2Z5QVW5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="3">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_0223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="162570">
        <property type="entry name" value="M.Rae11412ORF223P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86522">
        <property type="protein sequence ID" value="BAV86522"/>
        <property type="gene ID" value="RA11412_0223"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0223"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023095">
        <property type="entry name" value="Ade_MeTrfase_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481">
        <property type="entry name" value="PTHR30481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02086">
        <property type="entry name" value="MethyltransfD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00571">
        <property type="entry name" value="dam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
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    </evidence>
    <sequence length="539" mass="61853" checksum="B41876FFC377834B" modified="2018-10-10" version="1"> </sequence>
</entry>
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    <name>A0A2Z5QW04_9MICC</name>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">JCM 11412</strain>
        </source>
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    <dbReference type="EMBL" id="AP017895">
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
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    <name>A0A2Z5QW45_9MICC</name>
    <protein>
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        <lineage>
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="BAV86672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="52" mass="5656" checksum="4248E7FD5B9CDB33" modified="2018-10-10" version="1">MFLQVRDAVTGRGSARGSTFAPAPLAYSGITIQSIFVNDNYSQKCYAIARKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWC8</accession>
    <name>A0A2Z5QWC8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
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        <property type="gene ID" value="RA11412_0354"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016421222" evidence="2">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="107" mass="11003" checksum="AD1C860A36FAB985" modified="2018-10-10" version="1">MKSLGYGALGAVLSLPFVMSAAHAEIKPAPKEMCDGLDTMQAWVTGIAASLGVIGLVIIGAGMFFSHRHESGEGAFKKIGWWIGGAIVVTAAVGIASVFIAGKLNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWD6</accession>
    <name>A0A2Z5QWD6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine phosphatase PPP</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_06375</name>
        <name evidence="4" type="ORF">RA11412_0428</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86727">
        <property type="protein sequence ID" value="BAV86727"/>
        <property type="gene ID" value="RA11412_0428"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0428"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="588" mass="62486" checksum="AD5010948435AF75" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWG1</accession>
    <name>A0A2Z5QWG1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter integral membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_06275</name>
        <name evidence="2" type="ORF">RA11412_0449</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86748">
        <property type="protein sequence ID" value="BAV86748"/>
        <property type="gene ID" value="RA11412_0449"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0449"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="289" mass="31198" checksum="F84214A8D9A6F617" modified="2018-10-10" version="1">MSTAKTAPVAKNLSPIGVARSEWLKMRSLRSQQILFVVTIVVLLGLTMLLAPMLNLQLADYEKHAGQQIVNGEVVSGSEVVNQIKESSYSIGVVGASLAGIILSSMATVFIATEYATGSIQITQLTVPRRSLLYFTKALVASVVAFLVGTLGGIVAFFLGQMMLTEKLRVSMDTGVLRISLMLGFYLVVLAWMGFGFGALLRNSAGAIVLVAAILFVASIVLGIFKVTGQDWVDDAMKYLPSSLSNDVMIYHKDKIKGDPSYEVRCLILSLWGIVPLLAGWIRFKLSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWH8</accession>
    <name>A0A2Z5QWH8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dnaB</name>
        <name evidence="15" type="ORF">I6I94_06300</name>
        <name evidence="16" type="ORF">NCTC10207_02395</name>
        <name evidence="14" type="ORF">RA11412_0442</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="15 19" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 19">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 12"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI25057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887412.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86741">
        <property type="protein sequence ID" value="BAV86741"/>
        <property type="gene ID" value="RA11412_0442"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0442"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="13">
        <location>
            <begin position="182"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV86741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QQT88163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VEI25057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="454" mass="49971" checksum="2CE4D6B09CF0AFD1" modified="2018-10-10" version="1">MSETPVDYGSRTLPHDDVAEQSVLGGMMLSKDAIADVVETLRSTDFYKPAHEIIYEAVISLYGHGMPADAITVSDELKKRGELTRVGGATYLHTLIAAVPTAANAQYYADIVKEHAIMRRLVEAGTRIAQLGYSSDGEVDALVDKAQAEVYAVSDGNTAEDYVTFSEALEATVNEIDANANRPDGVYGVPTDFIEFDELTGGLHPGQMIVIAARPGVGKSTLALDFARSAAIHHNQCTVFFSLEMSRTELAMRILSAEGTISMSRLKKGDLDQDGWTQLANLQGKINGAPLFIDDSPNMTLMEIRAKCRRLKQRHELKMVVLDYLQLMSSGKKVESRQQEVSEFSRSLKLLAKELEVPVIALSQLNRGSEQRTDKRPMISDLRESGSIEQDADMVILLHREDMYNPDTDRVGEADMMIAKHRGGPTRTIPLAFSGKYSRFANMAFSDAPPQYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWM6</accession>
    <name>A0A2Z5QWM6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tat (Twin-arginine translocation) pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_06775</name>
        <name evidence="4" type="ORF">RA11412_0325</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86624">
        <property type="protein sequence ID" value="BAV86624"/>
        <property type="gene ID" value="RA11412_0325"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0325"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046281">
        <property type="entry name" value="DUF6318"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19843">
        <property type="entry name" value="DUF6318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033776936" evidence="2">
        <location>
            <begin position="28"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6318" evidence="3">
        <location>
            <begin position="67"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="234" mass="25019" checksum="8CB507C16D12895B" modified="2018-10-10" version="1">MTTSAYTRRTALMTVGMAAATALTGCASTLVPATTQTIEEGAASSSSSERTDFSGEAKIENYDTSAGTYEPATREHRAKNVPKPILPEEANKNSVAGLHANIAYLAAAYIYGFNSGDAECVGKSALSSEDKASLTRAIGRVSGSTWLADPTLIISLKEATPRQDGDTYTWPALLTLKIGPFRVKNRSVEEVPESERSHEFPMDIVARYKDERWVFDTLPNDSSSSPGAGGTSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWP1</accession>
    <name>A0A2Z5QWP1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86806">
        <property type="protein sequence ID" value="BAV86806"/>
        <property type="gene ID" value="RA11412_0507"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0507"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="191" mass="21074" checksum="D73A46BA77D09AD4" modified="2018-10-10" version="1">MNTRFLISPAYLLSIALLVAGAVLSGSRYMLIGWMLFLVGVFLNAMTLVILTNREQLRQIRQAHQHQKEQAEREQTGESPREPSAKELDVDPESQKEDAAEQDNTPQQGSESESASDVSAVADEPQDTNAADHEETSPQESTAAAQEQADSPTDRAAAAEQRTAGNAQSAQNMRRLKSSRKSRKPRKKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWS0</accession>
    <name>A0A2Z5QWS0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4,4'-diaponeurosporenoate glycosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">crtQ</name>
        <name evidence="3" type="ORF">I6I94_05795</name>
        <name evidence="4" type="ORF">NCTC10207_00068</name>
        <name evidence="2" type="ORF">RA11412_0569</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037236119.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86868">
        <property type="protein sequence ID" value="BAV86868"/>
        <property type="gene ID" value="RA11412_0569"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0569"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI22002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="245" mass="26942" checksum="A939AC98793C3950" modified="2018-10-10" version="1">MAQESSPHEPRTLIIMPAWNEEEVIGGTITELFRMMPEVDLVVVNDGSTDHTSEIARAAGAFVIDLPYNMGIGGALRTGYKYARRMDYDRAIQVDADGQHDPKGIRTVLAGLEDANISIGSRFAQATNYKVSGPRKWAMVVLARMFTMISGEKFTDATSGFRAADRRAINQYCEHLPAEYLGDCIDACVMAVRAGLTVKQVPVEMRERQGGTPSSSPIKSAIYLVRSFFSFGMSMTRKKTSVEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX07</accession>
    <name>A0A2Z5QX07_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86975">
        <property type="protein sequence ID" value="BAV86975"/>
        <property type="gene ID" value="RA11412_0676"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0676"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="152" mass="17554" checksum="D07CAFF6FF878549" modified="2018-10-10" version="1">MHDELLRYVSSYLTRQIGNRISAIAQDKKLTVRQRVEQACEQLLPLDAMRKREIVAYAELGRLERARPTGRLEEGQEIAKVCEASLDALDVHRVLDKARRAQLARRLHWVLDGLAAQEIIYPSYINPADIQEELRQTLDDIEREIADLIPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX47</accession>
    <name>A0A2Z5QX47_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Butyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86913">
        <property type="protein sequence ID" value="BAV86913"/>
        <property type="gene ID" value="RA11412_0614"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0614"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="179" mass="18868" checksum="A70B9460C29C23D8" modified="2018-10-10" version="1">MSNVTIEPLHSYPERERVLALAAEHADAVDAGERSPFENLREIAKDGLLTLGRTGSLVPQAAVAYDLASQDASTGFSLWAHRSTIAFFDAVNRELPEGLAEATTSGTTAMAAAYKEAAGIGPIKVLGTLVEGGVKLNGTVSWASNLYPNGVIVLPVAVQNAQEGHPNRYIVTVRQDTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX65</accession>
    <name>A0A2Z5QX65_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05335</name>
        <name evidence="2" type="ORF">RA11412_0681</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86980">
        <property type="protein sequence ID" value="BAV86980"/>
        <property type="gene ID" value="RA11412_0681"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0681"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT90010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="292" mass="32936" checksum="C4041C8A7B6D536A" modified="2018-10-10" version="1">MKAYDIVFDHTPEGATERVWSYDAMNRDMDSTPDKVTESGWLGNAGPNIPDNQWPRSSHSGLPMQHIFTLHLPEEYRTQGPEYVAVSFFAGDGQFAELGERAVPDPHSDDPFLVQLAEYTPHPKCRILTDILDSEYATIFLTEAEFSGRSHGPEDVRRQGEHREDAESYSAYSTYTRQKCERTLGLVERIDPNAGIAPVYEYTSDPDGEMTPKDVCSNGYEDPYDPDTRDDKPWAEPLYGRCHLGGTVFCVQNMPEGLTAWYIEFEEMDVMNFGGGNAQLDLESNTFDWACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX77</accession>
    <name>A0A2Z5QX77_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86824">
        <property type="protein sequence ID" value="BAV86824"/>
        <property type="gene ID" value="RA11412_0525"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0525"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="47" mass="4925" checksum="C73FB479EC639D90" modified="2018-10-10" version="1">MAEALAEAGDDAPACGELLDAEEHALNPRSRQAPAHSGATIRRDLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXC5</accession>
    <name>A0A2Z5QXC5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable integral membrane protein Cj0014c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87105">
        <property type="protein sequence ID" value="BAV87105"/>
        <property type="gene ID" value="RA11412_0806"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0806"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009898">
        <property type="entry name" value="DUF1440"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07274">
        <property type="entry name" value="DUF1440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="99" mass="11581" checksum="CDD515E66FA2F960" modified="2018-10-10" version="1">MHFTFAIFFAVLYCVVAEYWPKIKLWQGVAFGIVLDILFHVIIMPAMGVVPAPWNQPFGEHFSEFFGHILWLWSIELVRRDLRNRITGEPDAEYPVTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXE8</accession>
    <name>A0A2Z5QXE8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cardiolipin synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RA11412_0819</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87118">
        <property type="protein sequence ID" value="BAV87118"/>
        <property type="gene ID" value="RA11412_0819"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0819"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022924">
        <property type="entry name" value="Cardiolipin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04265">
        <property type="entry name" value="bac_cardiolipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV87118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="499" mass="57117" checksum="E8D52FD81CA5C2BD" modified="2018-10-10" version="1">MLGIIGKVNFFSTGYLDFLPDWLRIILFFADLSIRVLSLFWLPYNRKPVVALGWLMAIFFIPFIGFLAFLIFGSSHLPQYRRARQHAMNDLIRETTGGTPQLTDSDGLNEATLVASQLNYKLGSLPLVGGNSFTLHNDNHEAMRIMAQEVNKAQRYVHFEFYITAYDEASKVLWDALFAAQKRGVRVRVLIDHIGSRKYPSYRQLTKMLNESGIEWRLMLPIKPWRLQWQRPDLRNHRKVLVIDGAVAFSGSQNAIHRSYDLKENVRKSLEWKDLTFSCTGPIVEELNAVFVSDWYSETNQLILEEIEAKIPYVPGSMRAQVVPSGPGFETENNLRLINYMIYNAEKRITICSPYFVPDETLLQALTNAAFSGIETTVIVCEKGDQFLPNMAQRSYYETLLQSGVRILQYPSPTVLHSKFMYVDDEMAFIGSSNMDPRSFSLNLEVSTFIADAAMVDALADVARTYESICTELRYGPWSSRPQRIKVTENICRLWSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXP0</accession>
    <name>A0A2Z5QXP0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_0781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87080">
        <property type="protein sequence ID" value="BAV87080"/>
        <property type="gene ID" value="RA11412_0781"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0781"/>
    <dbReference type="Proteomes" id="UP000250241">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
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            <end position="113"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="222"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
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            <begin position="343"/>
            <end position="367"/>
        </location>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="384" mass="41132" checksum="D7740296D579EF8C" modified="2018-10-10" version="1">MNDLVDSAGSAQGIGYLPVLIILVLIIGAILNGVQQYFIQKVAESVARDARTQLVRKILRIPLDALEKYTKGDVLSRVINDTMLLRRCLTEGFVQSFVGVFTLIGAVIGMFFIDPLLLAISAVISLLAVVSVTMATSKVEKSSAQMQQAVGELSSDVSSVLEASSLVRTENAAGHQFKRLQQKVDNAWLKGIGVARLVALITPISAVAMQITFLVVLGVGGVRVANGIITVGNLVSFVMFLVMMIMPLGYIFGTMSNIAEASGGITRIQEILGIPDEYPEQLDTYHENRDIRSILLDNVSFKYGAEPEEGASPYLISGMTLSIAPGRRSPSWDPPVRARAPCCGSSPGFTKSQAGTSSTPAPQAQTFPSRLCAPKSAWCSRNPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXR7</accession>
    <name>A0A2Z5QXR7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NCTC10207_00397</name>
        <name evidence="1" type="ORF">RA11412_0933</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">NCTC10207</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="VEI22322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87232">
        <property type="protein sequence ID" value="BAV87232"/>
        <property type="gene ID" value="RA11412_0933"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0933"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VEI22322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <sequence length="131" mass="14967" checksum="7BB0207B9B3B7D24" modified="2018-10-10" version="1">MMSTESCWETIRENTLGRLVITDGQFVDVLPAFYGVTGDEIYLRTTRGDKLSSVVVSRRVAFEIDEPLPEGIRTVIVQGVAHWLPNEMTPDVVHTLGLRHFSDGNKMQWVRIEPRKVYGREYRLVETDSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXV3</accession>
    <name>A0A2Z5QXV3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_0874</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87173">
        <property type="protein sequence ID" value="BAV87173"/>
        <property type="gene ID" value="RA11412_0874"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0874"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016244544" evidence="5">
        <location>
            <begin position="39"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="54"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="327" mass="33683" checksum="33265F54BADE6327" modified="2018-10-10" version="1">MLFGVTGLLGSVGSLAAGVAAHGVTGASQVLVASGAAAESTSVEGTAQYVSIFWVSLVALVSPVISRLIGKRIPDVVFLLIFGMLIGPNVLGLASGSDGGIPLLKELGLGMLFLIAGFEIDVKSLRGRQGRSAITTWCVCFGLGVLGAALITGFTKGFNTYIAVGIALSSTALGTLLPMLKSHGAAGTRVGNAVLVHGAVGELFPIFAMSLLLSSHSPGLAILILLGFMAVAVVTAIVPHRLFEKVPGLRQIMAAEANTTSQTILRLAMFLLATLIMFAALFGLDAVLGAFAAGIILRSLTPVGALHLMTRRLETVGFSFLIPLFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXW5</accession>
    <name>A0A2Z5QXW5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-coenzyme A synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87074">
        <property type="protein sequence ID" value="BAV87074"/>
        <property type="gene ID" value="RA11412_0775"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0775"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="92"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="534" mass="58347" checksum="77B0D70C6E05742B" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY03</accession>
    <name>A0A2Z5QY03_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipid A export ATP-binding/permease protein MsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_0891</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87190">
        <property type="protein sequence ID" value="BAV87190"/>
        <property type="gene ID" value="RA11412_0891"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0891"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="362" mass="40125" checksum="C65A27E43A3632FD" modified="2018-10-10" version="1">MGLVVAIGAAVLEISVPQMLQFIVDELTRNATETGIWIGGSLVLLIGVGQASLAYWRRWLIVDPTSTMEMRMRMNFFDKLLRAPLSMIDRWSSGQLLTRSMSDLGTIRRWLSFALVQLISVAVMFLVGSSFMFGASWQLAVVFVVTVPVLLVSLVSYVRKYNAYTKELQQLTGDVSTRIEESVRGIRVIKALGRSQEEIQKYTAAVEELNSLDYRRSMLVALVAFYQRVIVGVSTLIALWVGVPQVASGEVSLGSLTAYFAVLTVVLGHVLRSTTLISSYLNYRVAMERHVEVMSENGHEEVVLTDEAAEQAPIPSGGVLSVTFDNVHFTYDPAQEPSSQEHSPKNTPSMRPHRAGCLRAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY07</accession>
    <name>A0A2Z5QY07_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87223">
        <property type="protein sequence ID" value="BAV87223"/>
        <property type="gene ID" value="RA11412_0924"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0924"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="366" mass="35363" checksum="4FBB131DBE5DCBD6" modified="2018-10-10" version="1">MWFKIQGGYGGGVDHANRNVGDGGAGADIEGTIKVTPGQTVKFHVGAGGLGLYDKPAAGGEGYGNGGSSNTLLETGVEVSDLDEMQSPTYNHIVVYSGSGGGASAVLISDKGSSEEKLLAVAGGGGGGGTRAMTQAARETLNGTKLAGWKTDGGFPVLSNGGDASDFPQAGSNGTEVYSEYPSAIVTVRGGNPGSGANGGAGGSKATYSTAKDLSFSSTTESNIRTSTVAGVAGGSGAKASGADGVVAYSYSISTKETDQPDGGSPYKFNVTAYAVSGGGGGGYGGGGSGAAAAIGAQTINVLGDGKTVSDAYSVSAGVVAGGGGGGGSFVAADVINPTFQRSSGQGTVRGESRDGIGQYAFCVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY63</accession>
    <name>A0A2Z5QY63_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_03630</name>
        <name evidence="1" type="ORF">RA11412_1106</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87405">
        <property type="protein sequence ID" value="BAV87405"/>
        <property type="gene ID" value="RA11412_1106"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1106"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="332" mass="37696" checksum="B883AA2CF37998FF" modified="2018-10-10" version="1">MTNPKLLLLSPAFHGYWKAIESSLEISGYQVRTHIYDAPGGVGARILNKLAHELPERFRPESLAAQATDKAIAVFNDYRPDIVLVIKGDKLGSRWWQVLEESGVRYGTWLYDELRRMEYTDDDLHRLGALASYSPLDAEHLRSKGFDVLDMPNAYDSHCQVTPTPENAISFVGARYPGREQTLRELYAAGLPVRAYGRAWSRHPWDMARTYQFKDPGVPSAGDIERSVAYGVMASSPATLNIHGDQDGFTMRTFEAPGVGALQIIDRPDVSRYYEVGKEVLVYESVEELIDICTRVFRDPRWAHAIREAGHRRTLAEHTFDQRVKILEQLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY78</accession>
    <name>A0A2Z5QY78_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87303">
        <property type="protein sequence ID" value="BAV87303"/>
        <property type="gene ID" value="RA11412_1004"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1004"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="77" mass="8800" checksum="379A6B624D596E02" modified="2018-10-10" version="1">MEYHAFEWRSIDAGGTSPLVRATTDLSYRCLGIGIPLGVIAALLKIITSVREDKKIREEQLRRLRADQHKQPPEKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYC8</accession>
    <name>A0A2Z5QYC8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87468">
        <property type="protein sequence ID" value="BAV87468"/>
        <property type="gene ID" value="RA11412_1169"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1169"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="406" mass="45004" checksum="B80108DF4789D35A" modified="2018-10-10" version="1">MTIYDELPAIYRIKRAQTDVDRIANEFYEASLDLDPVLATEHGRTGVETLFGDYSPAGEEAYAKLVKKTLKKLDKVIPIDDTDLVTLDAMQERLTLTRQMRRAGLGRWQLNNLFSAPQQIRTSFDLMSRENERDWAHIAGRLANVPGAIDGFIQTLEAARAEGKVSPRRQVQIVIEQAEAYIADGGFFDALGAEITAAAPAITEQAREGAQAAKDGYRALITYLRDTLLPEAPSKDAVGRELYTLYSRESLGASIDLDETYAWGVQELERIITEQHTVASEIEPGASIERAKELLDMDPVRALHGTEALQEWMQTHADTAVEALAGTHFDIGGPMLNIECRIAPTHEGGIYYTGPSPDFLARAACGGPCRRGMTPSPPGVKHPPCTMRACRGTTCRFQWLRRWRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYE2</accession>
    <name>A0A2Z5QYE2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87330">
        <property type="protein sequence ID" value="BAV87330"/>
        <property type="gene ID" value="RA11412_1031"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1031"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="46" mass="4846" checksum="EFE021815A5BDD84" modified="2018-10-10" version="1">MDILYRASSRTGFAAFAAFASSKRTARKAVAAITRTPTPIARSSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYF6</accession>
    <name>A0A2Z5QYF6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome C-type biogenesis protein CcdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_0975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87274">
        <property type="protein sequence ID" value="BAV87274"/>
        <property type="gene ID" value="RA11412_0975"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0975"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016450650" evidence="2">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="3">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="209" mass="21379" checksum="AD68A343D1B61BBD" modified="2018-10-10" version="1">MPAGTGMMLTPTAAAATAGAAPLASISSTVLDGSLWLSIPLAALAGLVSFASPCVLPLVPGYLGYVAGLAGSQPQAPEGSAAALFQGKKTAAAHNPTLQKTAENTKNPPEATSGWLWRPPPPTQNPQVRSPVRGAFTRSRPAATPAGCSPGWPCSYSGSPQFSSPYRCCWPRWVPPLAERAGVGEYSAGCTRDPHGRCVHGAAEHPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYH4</accession>
    <name>A0A2Z5QYH4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87396">
        <property type="protein sequence ID" value="BAV87396"/>
        <property type="gene ID" value="RA11412_1097"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1097"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="60" mass="7022" checksum="9C2B9A9BE382961E" modified="2018-10-10" version="1">MGWEFSRFDVSAAAQKIVELNRDYAQVTQRALQAHKFMSDKSFEKTNRMRAEHMMNVARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYL1</accession>
    <name>A0A2Z5QYL1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87557">
        <property type="protein sequence ID" value="BAV87557"/>
        <property type="gene ID" value="RA11412_1258"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1258"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="245" mass="27442" checksum="1729327A89981994" modified="2018-10-10" version="1">MIGVDIFFVISGYLITALLLREGATTGRINLLEFWKRRARRLLPAIALVILLMGPITQIMQGDIRVALDRQVLGAATFSSNWLSILSGNDYFTQTSPQLFTNFWSLAVEEQFYVIWPLLLVAMALILQRRWRLFAIAVGVLVVFSLTISTVLAAGEAPLSRVYYGTDTHMYGLLSGVLLAFAVPWSLYPPTDKHVLYTVSRPYGMVTFARVLISWVCLFALIPYAVLAHESAKFFIPWGCLALLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYL6</accession>
    <name>A0A2Z5QYL6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87558">
        <property type="protein sequence ID" value="BAV87558"/>
        <property type="gene ID" value="RA11412_1259"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1259"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="47" mass="5032" checksum="F0C0334B6D888FE2" modified="2018-10-10" version="1">MKQLFASAIAPEEGNQKFILPGLDGLRAIAVSLVIVYHLWPTVVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYN1</accession>
    <name>A0A2Z5QYN1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="13" type="ORF">I6I94_03025</name>
        <name evidence="12" type="ORF">RA11412_1263</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037233211.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87562">
        <property type="protein sequence ID" value="BAV87562"/>
        <property type="gene ID" value="RA11412_1263"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1263"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="31"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="373"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV87562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT89601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="572" mass="62236" checksum="1DC2C9D8637FAD9C" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYP0</accession>
    <name>A0A2Z5QYP0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DinG family ATP-dependent helicase YoaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87585">
        <property type="protein sequence ID" value="BAV87585"/>
        <property type="gene ID" value="RA11412_1286"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1286"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="23"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="549" mass="58713" checksum="AEC85E3834AF3880" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYP3</accession>
    <name>A0A2Z5QYP3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 17" type="primary">lexA</name>
        <name evidence="17" type="ORF">I6I94_02940</name>
        <name evidence="18" type="ORF">NCTC10207_00689</name>
        <name evidence="16" type="ORF">RA11412_1288</name>
    </gene>
    <organism evidence="16 19">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 19">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="17 21" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 21">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023132823.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87587">
        <property type="protein sequence ID" value="BAV87587"/>
        <property type="gene ID" value="RA11412_1288"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1288"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="15">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="14">
        <location>
            <begin position="109"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAV87587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QQT89586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VEI22608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="227" mass="24820" checksum="24B13152D7AD5820" modified="2018-10-10" version="1">MAPETPRPALTPRQQKILDAIRTEIEQKGYPPSMRQIGDMVGLASLSSVTHQLGRLEKMGYIRRDPKLPRAIEVLDASGNSEQRANTQAPKVPELPTFEVSDEDMVPIPLVGRIAAGGPITAEQSVEDVLSLPKQLVGSGKLFMLRVKGDSMIDAAICDGDWVVVREQHTADNGDIVAALLDEEATVKVFRQVDGHTWLMPRNSQYEPIMGDKATVMGKVVSVLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYS8</accession>
    <name>A0A2Z5QYS8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87513">
        <property type="protein sequence ID" value="BAV87513"/>
        <property type="gene ID" value="RA11412_1214"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1214"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="246" mass="26866" checksum="AD8313D1448B13E9" modified="2018-10-10" version="1">MNMTRDGAQATRTPMRACYLGVLLVLVALVLSACGARVETDLGLENAEKGSRTMSISFNMKDNKDYVKGDINSIDSSIKKHLPSELSYEGIQTDGDKARATFKLSFTSISEYRTKVENLLKLSGSSTTPTISISDSTTGLVQGVQVSENFSSKELLGWVPESLVVDGVIESKRKSSVLGTEDKTTVKMGDRELKNSSSSTPISVKDIKDNGFGFVLVDAQVQQNGSYTAKYFLLQKILWSLIKLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYV1</accession>
    <name>A0A2Z5QYV1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription termination protein NusA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_1237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87536">
        <property type="protein sequence ID" value="BAV87536"/>
        <property type="gene ID" value="RA11412_1237"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1237"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="118"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="330" mass="36005" checksum="B929454DC6A459CB" modified="2018-10-10" version="1">MSVDNNMTIDLSVLSTLEKERGIALEELFALVENALLLAYMKQPGAIKGSRAEIDRKSGQFVILAPELDDDNQKIAEFDDTPNNFGRIAAATVRQVLAQRLRDAEDASVLGEFRDREGTLVSGVVQQGNNPRMVQVDLGTVEAVLPANEQVPGEKYPHGARIRAYLVEARRGQKGPSIVLSRSHPNLVLRLFEHEVPEISDGLVKIASIAREAGHRSKIAVHATDPSINAKGACIGDMGARVRAVAAELNDEKIDIVDYSSDPAEFIAAALSPAKVTEVIIWMRVSIRPEPLYPMTSCRWLLVVRGRTPGLPLNSPGGVSIFSRNRSMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYV4</accession>
    <name>A0A2Z5QYV4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.13</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nudF</name>
        <name evidence="3" type="ORF">I6I94_02735</name>
        <name evidence="4" type="ORF">NCTC10207_00731</name>
        <name evidence="2" type="ORF">RA11412_1333</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.13" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87632">
        <property type="protein sequence ID" value="BAV87632"/>
        <property type="gene ID" value="RA11412_1333"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1333"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI22647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="236" mass="26260" checksum="90FAD8177D9F4075" modified="2018-10-10" version="1">MGDMSTKPAASSLNPEYADIVDTPSLREVTSREHKYCGHVLDVTVEKYLLSPHGPELTRDVVGMPGAVAVATLDEHDRILLLNQYRHPVRMNLWEVPAGLLDIEGEDPLAAAQRELAEEADLEAKTWHTLIDYYTTPGGADEAGRIYLARGLRRIPEGQRIPRGEEEAEITYRWVPLDAAVQLVLAGHIHNGLANQAIMAAYVASQVGFANLRSATDSWDFHPYLGGRRTRYRNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYV6</accession>
    <name>A0A2Z5QYV6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I6I94_02670</name>
        <name evidence="9" type="ORF">RA11412_1348</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transports L-lactate across the membrane. Can also transport D-lactate and glycolate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lactate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87647">
        <property type="protein sequence ID" value="BAV87647"/>
        <property type="gene ID" value="RA11412_1348"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1348"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="PTHR30003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00795">
        <property type="entry name" value="lctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="553" mass="57660" checksum="DEF92369D7E915D1" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYW8</accession>
    <name>A0A2Z5QYW8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_03060</name>
        <name evidence="1" type="ORF">RA11412_1254</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87553">
        <property type="protein sequence ID" value="BAV87553"/>
        <property type="gene ID" value="RA11412_1254"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1254"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="321" mass="36970" checksum="C4165EECB5366A50" modified="2018-10-10" version="1">MEPQQETSHDILESLLQELVEHEEDFSFYISLCLRLLARSPQHGWDVKAFMRGLEPEDMAAPRDPAKLRTNPKFLESEWLMGKYSILLEAFDEAVTSRHISTAAPKDTTLTGYDLRILWKIVNAHYSSYFEPDPRRRVTCAVEGLVGKDYSVEDLTGDLQDYLDRHACLLKLRDLCRELADRGKDLAFFTDLGVRLLEHVTWPVDDLRSFLQEIGSETVVEPVALPRLGWHQVYRTHENDVFSDSEQLLQKYSILADTLGELSSPAYSQVDLAARIARAQYELFFSRKPQERILAALRRLISDEYPAETLHRQLLDFLATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYX2</accession>
    <name>A0A2Z5QYX2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87675">
        <property type="protein sequence ID" value="BAV87675"/>
        <property type="gene ID" value="RA11412_1376"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1376"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="42" mass="4614" checksum="35BE67AA7D4A8906" modified="2018-10-10" version="1">MYAMCADGCQVYVSQKMYAAGQAFPPSLLKPGKLALRHILQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYX3</accession>
    <name>A0A2Z5QYX3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87434">
        <property type="protein sequence ID" value="BAV87434"/>
        <property type="gene ID" value="RA11412_1135"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1135"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="108" mass="12058" checksum="3826C4D39F10A7DC" modified="2018-10-10" version="1">MAEYSTPANTPLNDQLVRDLRADFPILGTQVNGHPLVYLDSGATSQKPLQVLDAERDFYLHANSAVHRGRTLSQLKPPTCSRMRELPLLVLWAPLTRNSCGPLTLLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ03</accession>
    <name>A0A2Z5QZ03_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_02540</name>
        <name evidence="7" type="ORF">RA11412_1383</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87682">
        <property type="protein sequence ID" value="BAV87682"/>
        <property type="gene ID" value="RA11412_1383"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1383"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="33"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="420"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="427"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV87682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT89522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="516" mass="55675" checksum="9C118E6B47069CF9" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ10</accession>
    <name>A0A2Z5QZ10_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87677">
        <property type="protein sequence ID" value="BAV87677"/>
        <property type="gene ID" value="RA11412_1378"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1378"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="4067" checksum="6D5A587FD27F066F" modified="2018-10-10" version="1">MSAQRRSKMLVIFSCGSHITSAGTEKTFMSYAFHALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ32</accession>
    <name>A0A2Z5QZ32_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR-repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87623">
        <property type="protein sequence ID" value="BAV87623"/>
        <property type="gene ID" value="RA11412_1324"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1324"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="119" mass="12930" checksum="4689ED92AD57A1DC" modified="2018-10-10" version="1">MAEAALGQGDYAEPEIFDIYGESDLLEPEENPATDEQPDSVETADLSEQEEAKTTSENTGVKETEASTDELHGENAPNVADEESEEDSIIDVAESAENKVKTNQDTLNSVRAQQQTEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ49</accession>
    <name>A0A2Z5QZ49_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diaminopimelate epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87581">
        <property type="protein sequence ID" value="BAV87581"/>
        <property type="gene ID" value="RA11412_1282"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1282"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="100" mass="10341" checksum="85EF13282BCAF6EC" modified="2018-10-10" version="1">MPLELEHDSGDIGVLGEQSEVGAIRLRVHERGVGETLSCGTGACAAAAATRFWGGEDAPDEWLVHVPGGTLAVTFVLGPDDLEHVVLAGGAQMVYTAQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZC1</accession>
    <name>A0A2Z5QZC1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative two-component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87845">
        <property type="protein sequence ID" value="BAV87845"/>
        <property type="gene ID" value="RA11412_1546"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1546"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="87" mass="9435" checksum="6D23DA46E7B097EE" modified="2018-10-10" version="1">MQEALTNILKHARDAQQVQLVVAWDRAGLGISAHNSAPQGKFSPVPGSGNGLRGMAERVNMYEGELSYGPDVQGGYTVRAHLPYREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZD4</accession>
    <name>A0A2Z5QZD4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="8" type="ORF">RA11412_1285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87584">
        <property type="protein sequence ID" value="BAV87584"/>
        <property type="gene ID" value="RA11412_1285"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1285"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="7">
        <location>
            <begin position="309"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV87584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="553" mass="60622" checksum="A8064DFF07E558DB" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZF9</accession>
    <name>A0A2Z5QZF9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_02545</name>
        <name evidence="4" type="ORF">RA11412_1382</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87681">
        <property type="protein sequence ID" value="BAV87681"/>
        <property type="gene ID" value="RA11412_1382"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1382"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PTHR21337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01358">
        <property type="entry name" value="DAHP_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="462" mass="51061" checksum="688D80B916CAC6EC" modified="2018-10-10" version="1">MSNTIRPQQPSDHGLDIWRTLNADQQPTWADHPDYAPTVAELEKLPPLVFAGEVDSMRHQLAEVAEGRAFLLQGGDCAETFAGATADKISGRVRTILQMAAVLTYGASMPVVKMGRIAGQFSKPRSSDVETRDGVTLPSFRGETVNGHEFTAEARTHDPKRMLRGYHTSSATLNLVRAFTKGGFADLRSVHQWNRGFTENPAHARYEETAREIGRALKFMEACGVDFNALTTTDLYVGHEALVLDFERALTRIDSRTHQPYDTSAHFLWIGERTRGINDAHVDFLSKVRNPIGVKLGPSTTTDDALALIDKLDPEREPGRLTFITRMGAKNIREKLPALVEGVNASGAKVVWVTDPMHGNTISVPSGIKTRRFDDILDEVRGFFEVHESLGSFPGGIHVEMTGDDVTECLGGSDPVDEAALANRYESLCDPRLNHSQSLEIAFLVSEYLKSQYVRQLGNTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZG7</accession>
    <name>A0A2Z5QZG7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Threonine synthase</fullName>
            <ecNumber evidence="6">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">RA11412_1454</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87753">
        <property type="protein sequence ID" value="BAV87753"/>
        <property type="gene ID" value="RA11412_1454"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1454"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="25"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="10">
        <location>
            <begin position="188"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)" evidence="12">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAV87753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="326" mass="34652" checksum="86F685F30F783367" modified="2018-10-10" version="1">MAHVWQGVINEYRDRLPFGDDVKPVTLGEGGTPLIHAPALSAQTGNTVYLKFEGMNPTGSFKDRGMTSAITAAKHEGAKAVVCASTGNTSASAAAYALQAGMRCAVLVPDGKISMGKLSQAIAHGADIIQIDGNFDNCLEIARKLSENYPVFLVNSVNPYRIEGQKTGSFEVVDTLGDAPDYHLLPVGNAGNITAYWKGYKEYSEPYTNRDGKILEPVATKRPIMWGFQAAGAAPIVAGHPIDTPETIATAIRIGNPASWEKAEAARDESGGVIEAVTDEEILEAHRWLSSREGVFVEPASAAGVAGLLKKHRAGEAPKARPLSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZH2</accession>
    <name>A0A2Z5QZH2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">rho</name>
        <name evidence="13" type="ORF">I6I94_02240</name>
        <name evidence="12" type="ORF">RA11412_1457</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87756">
        <property type="protein sequence ID" value="BAV87756"/>
        <property type="gene ID" value="RA11412_1457"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1457"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="280"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="182"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="400"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="412"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV87756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT89470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="657" mass="73733" checksum="85FF723B632AB81B" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZL5</accession>
    <name>A0A2Z5QZL5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_02340</name>
        <name evidence="3" type="ORF">RA11412_1432</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87731">
        <property type="protein sequence ID" value="BAV87731"/>
        <property type="gene ID" value="RA11412_1432"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1432"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="84" mass="9618" checksum="2551E66BCFD4E485" modified="2018-10-10" version="1">MKTMSYTESRARYAEVLNHVEDHREEVVITRSGHEPAVILSLSEYESLQETAYLMRSPANARRLMESISRLEAGLGAEHQLIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZL8</accession>
    <name>A0A2Z5QZL8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87664">
        <property type="protein sequence ID" value="BAV87664"/>
        <property type="gene ID" value="RA11412_1365"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1365"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="37" mass="3715" checksum="5328DD46C4A17B22" modified="2018-10-10" version="1">MCGLWGASGSCAAGSIAHGAITDLVLDEQLGRALIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZM7</accession>
    <name>A0A2Z5QZM7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible membrane protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">YGGT family</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">YggT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_02435</name>
        <name evidence="5" type="ORF">NCTC10207_00801</name>
        <name evidence="3" type="ORF">RA11412_1411</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888913.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87710">
        <property type="protein sequence ID" value="BAV87710"/>
        <property type="gene ID" value="RA11412_1411"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1411"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI22716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="99" mass="11131" checksum="821A2B1DE7438362" modified="2018-10-10" version="1">MGYLFAVLTIALYVLYIGLLLRMMFDWVRIFSPTWRPRGPVLVVASAVYGVTDWPMNLLRKVVPPLRLGNVALDMGFLILIIAVSFLLNGLQYLTAITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZN9</accession>
    <name>A0A2Z5QZN9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87833">
        <property type="protein sequence ID" value="BAV87833"/>
        <property type="gene ID" value="RA11412_1534"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1534"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015315">
        <property type="entry name" value="DUF1963"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035948">
        <property type="entry name" value="YwqG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09234">
        <property type="entry name" value="DUF1963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103032">
        <property type="entry name" value="SSF103032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="97" mass="10147" checksum="4C54F6AE1BA95611" modified="2018-10-10" version="1">MSSTAEKAIALIKQLNAENPLPVIEIKVSKAAEPLPVTVSKFGGVPYLPAGVEAPTDSDGNPMAMIAQINCAELPENPIYPPTGMVQFWIGAVTIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZX9</accession>
    <name>A0A2Z5QZX9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6493 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88032">
        <property type="protein sequence ID" value="BAV88032"/>
        <property type="gene ID" value="RA11412_1733"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1733"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="2">
        <location>
            <begin position="255"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="468" mass="51346" checksum="517BABA87A72B98E" modified="2018-10-10" version="1">MAETVEALPLDLQDTARKLMTPDDTVPPEPTGRTVSIPDIIPQDRAPGENLTPLPPIDNEAEFLDVLFGQLEGEEHGKNLQRLLVYLHEHPRVELDTATRKRIHTHNRTRTSDTPSAQALYLSYLVLKHHLNQNVLQPGTFPGYRENTYASPYGVLHRQLVALDTGAEAPLPPVPLPSVERIWERNVGKSYGTPQGWYELCYEGLGREFITWNAVGETEEDADLPLEQAARLTPANIRLAVSDRAQDALSNPQHRAVVQWYAWLMQNNPDILAAHYMPLAIAASLYKKSYGLDTVLGALAESWRVLTEPSHSLLAIACNAAGPDNRAAAAETLACLADRGMLDTNAYAAELRRLLERNNLKAPRIAQTLADAASISPLAGWRTLQILVEVLPVVGRVNRGGVLVQLLVQLAKEYGVSVTIPDELLPKMKGSTVLAKNLRVLHKLTEHPSDLAAQAAEQAQQVAAGNAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R005</accession>
    <name>A0A2Z5R005_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_01410</name>
        <name evidence="4" type="ORF">NCTC10207_01025</name>
        <name evidence="2" type="ORF">RA11412_1654</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037289029.1">
        <property type="nucleotide sequence ID" value="NZ_JPVS01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87953">
        <property type="protein sequence ID" value="BAV87953"/>
        <property type="gene ID" value="RA11412_1654"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1654"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI22931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="191" mass="20718" checksum="035D044BFEF0FB88" modified="2018-10-10" version="1">MSTTRALIIYGSVYGYTEQYATWLAEDLRALPQAPEVETVPAAKVTPEQAEAADVVVIGGSDYGGFLTGAPSLRKKIVPLLLPKRKRTAFFTVSFTGEYSKDLLNKAVAKSYTAELTEGQPVAHLRGGIKWSELSLTHKAALKGPVRAWLAAKPNPNEGIQQMLDCYGTEGADYTNRASLEPFAQEVAKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R014</accession>
    <name>A0A2Z5R014_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_01370</name>
        <name evidence="1" type="ORF">RA11412_1664</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87963">
        <property type="protein sequence ID" value="BAV87963"/>
        <property type="gene ID" value="RA11412_1664"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1664"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="403" mass="42687" checksum="329DD43E02121A8E" modified="2018-10-10" version="1">MSKNPPPSAPRTLEIIAEQNQGLPGQFLAAYSPKTQKIYIAGTFNAASHRGSCVATIARVDPQTLAIEATAQLPVIDEAHPNLIGEYQLCGAFGLSVDDTRGTIWVTDPTTSSVAVYDRDTFAPIWSSYQPDVSLEQQPVNHPREVLVLEDIGKAVVTGPGGYWFIDTGTYAITAHNPVPGSLPHTLTVTRDTLGGNIYLSDYNLDKVYEVSPAIGEAVRTINVPAGETSDFSRVNTHGVAINNSLNEIYVSTQGENGKNSGVQVLDKISGSFKQFIPYGITPTDIIADETRDLVYLTDFGPTSVHPADSGGGTVAVIDARTKSVVAEVHIASGKANHLTLLPDGMVIALDKAGTHKNVEVGFHIDPVTGKHVNSAIDVHASGTTPINADSITKITVALNNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R039</accession>
    <name>A0A2Z5R039_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetone carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_00990</name>
        <name evidence="1" type="ORF">RA11412_1778</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887165.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88077">
        <property type="protein sequence ID" value="BAV88077"/>
        <property type="gene ID" value="RA11412_1778"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1778"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="75" mass="8694" checksum="19F96B3C5733768F" modified="2018-10-10" version="1">MDLLGSLSGDAAPTGDICSRKGCTTEATHQILWNNPKIHTPQRRKIWLACDEHTAWLENYLKERQFWKQTLPFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R077</accession>
    <name>A0A2Z5R077_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_00650</name>
        <name evidence="1" type="ORF">RA11412_1866</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88165">
        <property type="protein sequence ID" value="BAV88165"/>
        <property type="gene ID" value="RA11412_1866"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1866"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="363" mass="41611" checksum="C6877D4784598A59" modified="2018-10-10" version="1">MGGYIYGLPKFWEINSNFAEFLQDLHQYKNKVHELDRIQFSEGANLQTIFPVLWEEVLQHHPSIHLRFYAYSNFDVDWIASFTDLENLSIEVGGNNSIIRNLEKLAEFQSLKSLVLSADNGFGNLNFLNGVNPKLQELYLCSKTKSAKSDLSVLTSFQHLETLSLLNLEKNLDKAVSSLSALEKLTLRSISKPQHIDFINGLKNLQFLTLQLCSFENIDAAAQLLKLKYLQLWRLPKLENLDFVSQMQGLQFLFVETLNGITRFPKVAGLKHLRRVKIASCKNLTDFSEVAYSHSIREFAVQNATQPNLDIYIPIIENQHIENLGIGHEKAAIQKEMQALAQKHGREQITVCMYPDFEQFVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R090</accession>
    <name>A0A2Z5R090_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88033">
        <property type="protein sequence ID" value="BAV88033"/>
        <property type="gene ID" value="RA11412_1734"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1734"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="208" mass="23672" checksum="E036DB8351C6AC39" modified="2018-10-10" version="1">MTTSEHKTLTLTERRTRLKQLIAEHKPVEEYQKVLSGATEEERASLVRTLSPTKLKEPKNRFTPLGTYAVTALTKKPARAAQLILQLCWDNYKHRDAIARYAAAGASERPNDWVLEYVAETCFMDELWPLSQTLLRERGLICEDEEYLKGFQARIPAVNTASTHNHQEALEFLQKILPALRSSGHFSGWRAPCWRNTPTDFSTPTAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0C1</accession>
    <name>A0A2Z5R0C1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1692</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="162566">
        <property type="entry name" value="M.Rae11412ORF1692P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87991">
        <property type="protein sequence ID" value="BAV87991"/>
        <property type="gene ID" value="RA11412_1692"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1692"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HsdM_N" evidence="4">
        <location>
            <begin position="28"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="3">
        <location>
            <begin position="168"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV87991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="524" mass="58558" checksum="C5E098480DF15494" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0I7</accession>
    <name>A0A2Z5R0I7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative stomatin/prohibitin-family membrane protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87994">
        <property type="protein sequence ID" value="BAV87994"/>
        <property type="gene ID" value="RA11412_1695"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1695"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="86" mass="9978" checksum="872B3814E1D99AF4" modified="2018-10-10" version="1">MDSLTILSIVIPIILILAFLIIRTLRVIPEYQRGISFRFGHLRSELKPGINMVIPLIDSLQRVDMRVITLTIPRRRLSLKITFRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0R8</accession>
    <name>A0A2Z5R0R8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88084">
        <property type="protein sequence ID" value="BAV88084"/>
        <property type="gene ID" value="RA11412_1785"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1785"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="2">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="235" mass="25207" checksum="49D21A7974506B6F" modified="2018-10-10" version="1">MLMHIPKDGSGVYLISIMRDSWVNIPGYGSAKVNAALNYGGIGLQVATIEQLLGIKIDHVAEIDFTGFKDLTNAVGGVDVQVPVAFKTGVWSYTPGTMHMDGSTALAFVRERYSFAAGDYQRVRNQRAYLRGLYNTLKAQGALSSIGKFKTVVDSLSGYLTVDKGLDSSQVANLAAPVITNGSTAMHMMSLPNAGPGWSMDGQSIVLVDQKANADLTRALQNDKITDFTSVYGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0U3</accession>
    <name>A0A2Z5R0U3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00150</name>
        <name evidence="2" type="ORF">RA11412_1993</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88292">
        <property type="protein sequence ID" value="BAV88292"/>
        <property type="gene ID" value="RA11412_1993"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1993"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="260" mass="28366" checksum="48C8ECC0F35258A2" modified="2018-10-10" version="1">MATLITGASSGIGEEFAHHYAAEKHDLVLVARSEDKLNTLADTLRGQHGIQVTVIALDLSEPDAAQRLWEETNRARLEIDVLVNNAGFGTHGDVADDNPDRLEQEVRLNCLTLTGLTARYLPAMRERKTGTIINIASTAAFQPLPHMAVYGATKAFVLSFTEALWAETRKDGIRVLAVCPGPTDTSFFEIAGESAAVGKMRSTRQLLDSTLQALKTTKPSFVDGLGNAVVARFVTRVVPKRAVMAIVDQAFQRQRSQHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0V1</accession>
    <name>A0A2Z5R0V1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbpA</name>
        <name evidence="4" type="ORF">I6I94_00830</name>
        <name evidence="5" type="ORF">NCTC10207_01141</name>
        <name evidence="3" type="ORF">RA11412_1815</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887345.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88114">
        <property type="protein sequence ID" value="BAV88114"/>
        <property type="gene ID" value="RA11412_1815"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1815"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VEI23044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="113" mass="12988" checksum="26A29B51EEB1143C" modified="2018-10-10" version="1">MSDRSLRGMRLGSQSMETESNVQPAPRQRVEYRTADGDRVFVTFAAEAEIPQTWTAKSGKEAFLVNGDSGSSAEDEKPVRTHWDMLMERRSIEELEKTLEDRLQYYRSHFAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0V4</accession>
    <name>A0A2Z5R0V4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88368">
        <property type="protein sequence ID" value="BAV88368"/>
        <property type="gene ID" value="RA11412_2069"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2069"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M78" evidence="1">
        <location>
            <begin position="188"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="259" mass="29337" checksum="05BFA145692DCFA5" modified="2018-10-10" version="1">MTVKVPVEPSVLRWALDRADMSETEKAFDKLRVSEWLRQDSQPTISQLTKFAQKTHVPFGMLFLSEPPVEEKPLADFRFRGSAPEKYSAELTETILEQQRRQNWYRDYAIARGLEVNEYVGSETLASNPEQVADRIRYDFGYTPGMVRSGTEARKAIIELLEENGFLISVAGVVGSNTHRPYDPNEFSGFSLSNDYAPTIFVNGRDTKNAQIFTLLHELGHLLLGESGVSVSGGEEVHQQHAEQQAYNERWCDSFAAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0X7</accession>
    <name>A0A2Z5R0X7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WYL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88134">
        <property type="protein sequence ID" value="BAV88134"/>
        <property type="gene ID" value="RA11412_1835"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1835"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="75"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="279" mass="31262" checksum="E1DD6095CFEBFE11" modified="2018-10-10" version="1">MEYLPLEAGHQLYAGVAFSDVELALLVFSLDAAQHILGRSEQLSRLRDTIANSYGDRAGELSRALSFRPDAPWRTEILEALASSRALRIRYGDQDFERVIDPYGLVFMYNQFYLYAFCRTSAGRVGQRDAWRNFRLSSITHLEDAGPAHPRTPPAHAHTPEQWSRAQQFDEDNPFALLRVRVEALGSPGSSAVKEACHRLLRVSSHAVALDAAKPNSPKVFHRVHYFPGERRQGMRRILDTVIDGGGALELLGPQQLRAELLERIDVLMVEEGSPDAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R113</accession>
    <name>A0A2Z5R113_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Predicted D-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_00375</name>
        <name evidence="6" type="ORF">RA11412_1931</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88230">
        <property type="protein sequence ID" value="BAV88230"/>
        <property type="gene ID" value="RA11412_1931"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1931"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="50"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="544"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="967" mass="104693" checksum="7EA9F09C51496309" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R139</accession>
    <name>A0A2Z5R139_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_1902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88201">
        <property type="protein sequence ID" value="BAV88201"/>
        <property type="gene ID" value="RA11412_1902"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1902"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="136"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="417" mass="46581" checksum="98C182E1F1FC2DD4" modified="2018-10-10" version="1">MLRTHTNGELTAANIGETVTLTGWVARRRDHGGVAFVDLRDRAGVTQCVFHNEDDFEHLRNEYVLRVTGQVTKRPEGNENPNLATGEIEVEVSAVEVLNTAAPLPFQIDEHVEVGEEARLRYRYLDLRRPEPARIMRLRSDANRAARNLLADDGYLEVETPTLTRSTPEGARDFLVPARLAPGSWYALPQSPQLFKQLLQVGGIEKYYQIARCYRDEDFRADRQPEFTQLDIEASFVDQDDIIDLGERIIEAVWNLIDVQVPRPIRRMTYAEAMEKYGTDKPDLRFGLELTELTDYFANTTFRVFKAPYVGAVVMPGGASQPRRTLDAWQEWAKQRGAKGLAYVLVQEDGELTGPVAKNITDEERAGLAAATGANPGTASSSPPVKLSRRVLCWALPVLRSATVPVLLRTASGRSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1B9</accession>
    <name>A0A2Z5R1B9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="2">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ndk</name>
        <name evidence="5" type="ORF">I6I94_00090</name>
        <name evidence="4" type="ORF">RA11412_2007</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88306">
        <property type="protein sequence ID" value="BAV88306"/>
        <property type="gene ID" value="RA11412_2007"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2007"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="3">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV88306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="137" mass="14932" checksum="C6039081853DA9B3" modified="2018-10-10" version="1">MSERTLILVKPDGVERGLIGQILSRFESKGYTIEKLKMLQPTKELLAQHYAEHEGKPFYQPLVDFMVSGSVVAAVLSGERVIEGVRSMLGTSDPTLAAPGTIRGDLGRDWGDSVQKNLVHASDSPASAKREIALWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1C1</accession>
    <name>A0A2Z5R1C1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88478">
        <property type="protein sequence ID" value="BAV88478"/>
        <property type="gene ID" value="RA11412_2179"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2179"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="200" mass="23101" checksum="010BAF75C5204F0C" modified="2018-10-10" version="1">MLVTVVGTKFLAGAWLSLTFILLLSEVMLMTRRHYARVDKLTEIPLDQEAAADAAALPSRVHAVVYIERVRQPALRALAYARAARPSTIEALTVNNDRQLLATVKERWDMLHIPVQLSVIDSPYRDTVSSVLDYVRRKRKKSPRDVVVVYLPEFVVAHWWQEILHRRTVRRLKKRCCTNREWQPPPYRGLSTPPRPSRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1L2</accession>
    <name>A0A2Z5R1L2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FeS_assembly_P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88675">
        <property type="protein sequence ID" value="BAV88675"/>
        <property type="gene ID" value="RA11412_2376"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2376"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="73" mass="7721" checksum="77771C3B0B9F54EA" modified="2018-10-10" version="1">MSEHNPKGTNSNTPASNSPLADALWAALGTVEDPELRRPITELGMVERAQAVSEDDGGYVADVKILLTIEGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1R2</accession>
    <name>A0A2Z5R1R2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88500">
        <property type="protein sequence ID" value="BAV88500"/>
        <property type="gene ID" value="RA11412_2201"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2201"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="38" mass="4302" checksum="9B24A245A224AF68" modified="2018-10-10" version="1">MMGVPVCSVLCGSLKKMSTRGFSRWCSIFLFLNRYVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1Y6</accession>
    <name>A0A2Z5R1Y6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I6I94_10445</name>
        <name evidence="7" type="ORF">RA11412_2255</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88554">
        <property type="protein sequence ID" value="BAV88554"/>
        <property type="gene ID" value="RA11412_2255"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2255"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033340103" evidence="6">
        <location>
            <begin position="27"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="332" mass="35440" checksum="31F9509E9E9CEE06" modified="2018-10-10" version="1">MKKILGAASALLMTSALLTGCATSNNSSGGSGGGSNTAKVKVVTSTDVYADLVKQVGGDNVDVHAFVSSTATDPHSYEASASDKLQIKDAKLAVVNGGGYDYFLEKDAGQNNQKVVNAVKTSGKLSDADYDHLIEHHSGGEGHGHNHGSEAEEGGGHEHAHEFNEHLWYDFDTVKKVTNKIADDLAEIDSSHADQYRENAKKLTGEIDSLEESAKKINGKGKKYIATEPVPDYLISSTGAENSTPAEFAEAVEEGKDVPAITLQETKDLVTEKKVNLVAYNSQTETSQTKEVLQSAKDSGVANVSFTETLPENTKYVDWMKSNVSNLEKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R242</accession>
    <name>A0A2Z5R242_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oligo-1,6-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88788">
        <property type="protein sequence ID" value="BAV88788"/>
        <property type="gene ID" value="RA11412_2489"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2489"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="11"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="590" mass="67277" checksum="1C9C4E704C66B111" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2F6</accession>
    <name>A0A2Z5R2F6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1778 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_09715</name>
        <name evidence="1" type="ORF">RA11412_2431</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887487.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88730">
        <property type="protein sequence ID" value="BAV88730"/>
        <property type="gene ID" value="RA11412_2431"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2431"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014795">
        <property type="entry name" value="Vibrio_phage_ICP1_Orf50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35401">
        <property type="entry name" value="PTHR35401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08681">
        <property type="entry name" value="DUF1778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="97" mass="11130" checksum="6C93B15DD181E493" modified="2018-10-10" version="1">MSTTVKSQRINLRASERQEALIRQAAEVTDSSVSDFILSSATERAEHVLADRRWFVATEEQYDLFVQALEAPTRTEKLERLFARESPVGKEIVFKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2G9</accession>
    <name>A0A2Z5R2G9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Respiratory nitrate reductase gamma chain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="16">Respiratory nitrate reductase subunit gamma</fullName>
            <ecNumber evidence="16">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">narI</name>
        <name evidence="16" type="ORF">I6I94_09015</name>
        <name evidence="15" type="ORF">RA11412_2594</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="16"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88893">
        <property type="protein sequence ID" value="BAV88893"/>
        <property type="gene ID" value="RA11412_2594"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2594"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003816">
        <property type="entry name" value="Nitrate_red_gam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00351">
        <property type="entry name" value="narI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <dbReference type="Pfam" id="PF02665"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
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    <sequence length="279" mass="31171" checksum="AF01E88F07BF898A" modified="2018-10-10" version="1">MYALASEHAAHGVPVPVGEPGIVDILLWGVLPYVTILILIGGTIWRYRTDQFSWTTRSSQIYESKMLRLGSPLFHYGLAAVFMGHVGGLVVPKMLTDYVVDDHTYHIVALVGGSAAALATIAGLALLLWRRRNNAQVFTATTANDKFMYFVLVAVILAGTAATLFSAINPSGGLPPVNGHEVEFNYRTSVAVWFRSIFYFHPEVALMVNVPLSFKIHIIAAMVLFIIWPFTRLVHALTMPLHYLFRPYTIYRSRGGERVGARRGWDPIGTHDREDVFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
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            <authorList>
                <person name="Nambu T."/>
            </authorList>
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            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 6">FDAARGOS_1137</strain>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="BAV88774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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</entry>
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    <accession>A0A2Z5R2P8</accession>
    <name>A0A2Z5R2P8_9MICC</name>
    <protein>
        <submittedName>
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    </protein>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88973">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="63" mass="7110" checksum="F40D76585A07CC38" modified="2018-10-10" version="1">MTEQEEHKRHILSEYAAQILAATTRSAGSLEDNLVDVFRGYIFLPLKTRPSAPKTSLIAHETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
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    <name>A0A2Z5R2Y6_9MICC</name>
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            <fullName evidence="5">ABC-type amino acid transport/signal transduction systems</fullName>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88982">
        <property type="protein sequence ID" value="BAV88982"/>
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        <property type="component" value="Chromosome"/>
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        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        <location>
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        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="335" mass="35041" checksum="095593DF16C7A1A4" modified="2018-10-10" version="1">MTTATKKTLALFALAPLLLSGCVSTESSGSGGGSVNLIKSDTLSVCTNTPYKPFEYEENGKVIGLDADIAEAIAKDLGVKAQLTSISFEGLDSGTGLTSGQCDIALAGISVTDARKSKMAFSNVYFEDKQAILVPKDSKISSAADLKGAKVGAQQATSGEEYAKNQGADVTQYEDTSLMISALETGKVQAVSANLSVISEALKANPSLKIAYETSEGADEIAAAVSPPTPPCWRKPTRASTSSRTAANSISSKKSGWGLLPPQAPPPRPPRAKAPSTSVTTTHSPTRYEQIDGTDKALTPQKTGDISVHPVRAARSHCDYCARHGRLEYAHQTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Z9</accession>
    <name>A0A2Z5R2Z9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-Q tRNA(Asp) synthetase</fullName>
            <shortName evidence="5">Glu-Q-RSs</shortName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gluQRS</name>
        <name evidence="5" type="synonym">gluQ</name>
        <name evidence="10" type="ORF">I6I94_08560</name>
        <name evidence="9" type="ORF">RA11412_2703</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89002">
        <property type="protein sequence ID" value="BAV89002"/>
        <property type="gene ID" value="RA11412_2703"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2703"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01428">
        <property type="entry name" value="Glu_Q_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022380">
        <property type="entry name" value="Glu-Q_tRNA(Asp)_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03838">
        <property type="entry name" value="queuosine_YadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="8">
        <location>
            <begin position="26"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glutamate binding" evidence="5">
        <location>
            <begin position="26"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="5">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="5">
        <location>
            <begin position="253"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV89002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT88574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="327" mass="36384" checksum="23C033F047A15CE4" modified="2018-10-10" version="1">MTREPHLNAAPVTVSPSPSVHPGAGRYAPSPSGDLHLGNLRTALLAWMLARQGNLRFVMRVEDLDRVKEGAAQQQLADLASLGLDWEQPVLYQSTRRKAYQREFERLQEAGMVYECYCTRREIQQAATAPHGAPGAYPGTCRELSDQQRAERRAHRAPAYRLRAEVSEYTVHDMFRGDYTAAVDDVVLVRNDGTFAYNLAVVVDDYFQGVTQVVRGDDLLSSAPRQAYVAHLLGYPPVTYAHVPLALNEEGKRLAKRDGAVTLPQLRQAGFTEADVLSWIAASIPVADPKKTGGAQVFESAMHILRFFDPQRMSLEPWTVRDPLKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R315</accession>
    <name>A0A2Z5R315_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpmC</name>
        <name evidence="7" type="ORF">I6I94_09135</name>
        <name evidence="8" type="ORF">NCTC10207_01774</name>
        <name evidence="6" type="ORF">RA11412_2562</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887703.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88861">
        <property type="protein sequence ID" value="BAV88861"/>
        <property type="gene ID" value="RA11412_2562"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2562"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI23861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="79" mass="8962" checksum="17D2000ECDEC7D6A" modified="2018-10-10" version="1">MAVGSKDLSIDKLAELSNEELAEKLSESKKELFNIRFQEVTGQANAGRRRTIKRDIARIYTVLRERELGIRPATEGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3M4</accession>
    <name>A0A2Z5R3M4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">grpE</name>
        <name evidence="5" type="ORF">I6I94_02625</name>
        <name evidence="4" type="ORF">RA11412_1360</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87659">
        <property type="protein sequence ID" value="BAV87659"/>
        <property type="gene ID" value="RA11412_1360"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1360"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT89537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="258" mass="28189" checksum="07FCD2D5C9260977" modified="2018-10-10" version="1">MSDNIPETLYTSQPALHAREGEQNTEDKAANTDYPHTADGSTATAQPVPQENIHSQSVTVSAFVTPGFEERVLGELEELRNRFTHKIAEDRAKNQLIVSVQQSLRERDETARGEAYRSIFKEILVALDRLISQEPSAALTESVREEILDILALRGLERIEAKGLYNPAIHEVAGVVPADETHPAGSIVSEVKEGFMLADRVLRPALVTVARAAQVSNGVQPETTYTEPSENTIEASGTLQPHNPTAVPQAEPNETHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3R7</accession>
    <name>A0A2Z5R3R7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-Acetyl-D-glucosamine ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87879">
        <property type="protein sequence ID" value="BAV87879"/>
        <property type="gene ID" value="RA11412_1580"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1580"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="64" mass="7076" checksum="78B81EC5F8766894" modified="2018-10-10" version="1">MNTVQKGSSPRMRGTPTNVLIDPEEEGLIPTYAGNTCRLCGSQYPSRAHPHVCGEHLLDKVIIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3Z0</accession>
    <name>A0A2Z5R3Z0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88139">
        <property type="protein sequence ID" value="BAV88139"/>
        <property type="gene ID" value="RA11412_1840"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1840"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="70" mass="7826" checksum="57306F99DE55C7D7" modified="2018-10-10" version="1">MSRVIEEGSGEAIQDGDNILVEITQFNGTDGSSKDAQGREQTTYASAPFNITVNEQLKEEDPRHMRRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4F1</accession>
    <name>A0A2Z5R4F1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_2200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88499">
        <property type="protein sequence ID" value="BAV88499"/>
        <property type="gene ID" value="RA11412_2200"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2200"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="93" mass="10218" checksum="5AC071092FEEFE06" modified="2018-10-10" version="1">MRERAEHGLSRSSRPAAPAGAERESFSTQAQQRPAQAETTRADTATVPTEGTSTESKPEPAETKRHEKPKSSGRNKQRMSVPAWDEIIFGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4J8</accession>
    <name>A0A2Z5R4J8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Electron transfer flavoprotein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Electron transfer flavoprotein subunit alpha/FixB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I6I94_10195</name>
        <name evidence="6" type="ORF">RA11412_2310</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88609">
        <property type="protein sequence ID" value="BAV88609"/>
        <property type="gene ID" value="RA11412_2310"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2310"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="5">
        <location>
            <begin position="21"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="ETF_alpha" evidence="4">
        <location>
            <begin position="211"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT88875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="334" mass="34612" checksum="84C4F7E56BA3BD70" modified="2018-10-10" version="1">MTTAYRVLVISGTTNFATEPSGVDRELLALARLRAGIGQGGTQLGVLTFAQGSADIAQFYAEQGAARVFAPAQSLTDALPAARVELAVQAITEFGPDVVLAPHDIDSIELLGRVAVRLGNSEAGSRPVGVVTGAHDVDDALNIHKNVLAGEYDSTVRVEGLPLVTLRPNSVDTAAAPTAVGEGVLTTYTLPGYDTVRITEITEKPASTRPDLEEAAIVVAAGRGIGGNLAPIEDLADALGAAIGSTRAVTDAGWLDHSTQIGQTGKSVSPELYVSVGISGALQQKVGMDTSKTIVAINKDADAPIFEIADFGVVGDLFTVIPQAVQEIHKRKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4N3</accession>
    <name>A0A2Z5R4N3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-succinyl-L,L-diaminopimelate aminotransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Succinyldiaminopimelate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09885</name>
        <name evidence="2" type="ORF">RA11412_2390</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88689">
        <property type="protein sequence ID" value="BAV88689"/>
        <property type="gene ID" value="RA11412_2390"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2390"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019880">
        <property type="entry name" value="OxyQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03539">
        <property type="entry name" value="DapC_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="44"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="385" mass="41214" checksum="C7B9976B0AC5EF11" modified="2018-10-10" version="1">MRTYGIDLPEYPWEALAPYRAIAAEHPGGTVDLSIGTPVDSTPQLIQDALAAGANAHGYPTTHGTLELRQAIVDWFARRRNVHGLSADQVMPTVGSKELVAWLPFLLGLGTHPETGERDVVVYPRAAYPTYEIGARLAGADHYAADSLTELPEDVKRRVRLVWVNSPANPNGVVRGVEQLRELVRHARDIGAVVASDECYAELGWGEWDTARGGKPVPSILDERVCAGDFTGLFAAYSLSKQSNLAGYRAAFIAGDAQIMPNIINTRKHAGMIVPAPVQSAMIAALTDDAHVAAQKDIYRARREILVEAITAAGGRIEGSEAGLYLWTTFGESTWESIERLAKLGIVAGPGVFYGEGCDGYVRIALTASDAAVAAAAERLKGSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QV95</accession>
    <name>A0A2Z5QV95_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86315">
        <property type="protein sequence ID" value="BAV86315"/>
        <property type="gene ID" value="RA11412_0016"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0016"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019662">
        <property type="entry name" value="DUF2516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10724">
        <property type="entry name" value="DUF2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016302884" evidence="1">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="64" mass="7003" checksum="00456AB321911C91" modified="2018-10-10" version="1">MSPIQLVMLFMYWADLVLSVAAAATCVWAFVQAAAAAPNAYKFHDKRTKGFWMGLTGGSALFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVA5</accession>
    <name>A0A2Z5QVA5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86306">
        <property type="protein sequence ID" value="BAV86306"/>
        <property type="gene ID" value="RA11412_0007"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0007"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070567">
        <property type="term" value="F:cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="123" mass="13627" checksum="0F8325FD81EA566C" modified="2018-10-10" version="1">MYQRVLDELNTGSDAVIPVLPVVDTIKTVDAYGYVTGTPPRSQMRAVQTPQGFEWWVLEAAHRRSRRLPPEESEKITDDAMAVEAAGRRVVTVRGHMDAFKITTPMDLRIARALYAAPDSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVC1</accession>
    <name>A0A2Z5QVC1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86330">
        <property type="protein sequence ID" value="BAV86330"/>
        <property type="gene ID" value="RA11412_0031"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0031"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_II" evidence="1">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="2">
        <location>
            <begin position="63"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="203" mass="22068" checksum="449F33E9D3142EAC" modified="2018-10-10" version="1">MPLYFELDGTFPNHPANPLEPANLVDLQKAVVEHGADIGLAFDGDADRCFVIDEKGNAVTPSAITALVAEREIARAKAEGNEQPVIIYNLITSKAVPELVEKLGGRAVKTRVGHSFIKAVMAEESGIFGGEHSAHYYFKDFFNADTGMLAAMHVLAALGGGHQALSEISASYSPMWHPVRSTPRLRTRQPLWTVYARTTLARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVF3</accession>
    <name>A0A2Z5QVF3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86361">
        <property type="protein sequence ID" value="BAV86361"/>
        <property type="gene ID" value="RA11412_0062"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0062"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028228">
        <property type="entry name" value="Imm53"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15580">
        <property type="entry name" value="Imm53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="70" mass="7851" checksum="03031E67C9C71502" modified="2018-10-10" version="1">MYGVEIDTLDNPGWTVSLTGETDKKSINIFVDRSEDNWLSVKSCDDNFVAYGGINNLEEILAHAVEWINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVJ1</accession>
    <name>A0A2Z5QVJ1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-phosphoglucomutase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">HAD family phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_07760</name>
        <name evidence="1" type="ORF">RA11412_0103</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86402">
        <property type="protein sequence ID" value="BAV86402"/>
        <property type="gene ID" value="RA11412_0103"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0103"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="221" mass="23923" checksum="03E15ED11C8A3EE4" modified="2018-10-10" version="1">MNSNIQADFPQAILFDHDGTLVDTEPVWAAAKVELAAEFGGVWTAQDTLDCLGYSMKFTLDRLRERGVDLPDEQINERLVAKVREALAHQQVEFLPGIERFLTQVRDAQIPAAIVTNATTAVAQRTADAAPEGTFSVVIGNDETTHPKPNPQPYLLAAQRLGVDPSQCVAIEDSPSGVRSATDAGMKVIVVPGELEVPAGLGDVRLRHEELELSVFKALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVM1</accession>
    <name>A0A2Z5QVM1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86443">
        <property type="protein sequence ID" value="BAV86443"/>
        <property type="gene ID" value="RA11412_0144"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0144"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="198" mass="21824" checksum="FC2FC24C19572D71" modified="2018-10-10" version="1">MTVSTGGADWRDGATAEQVAAVEHLYRNHRSLPYISPKRDLAAWLEEVELSSSKAVPKWALEPVADIELYGGYLFEVTAGDIILLWRISFDTFTTQSWFPKYFEYVYGIDAAFDLRMLVEAGVVEVESAADSLDLVTAPALRKALKDAGVNDLSSAKKADLMRLAREHLSPPNLRTRSPCGLISSPPQGGHYLTPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVS4</accession>
    <name>A0A2Z5QVS4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0183</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86482">
        <property type="protein sequence ID" value="BAV86482"/>
        <property type="gene ID" value="RA11412_0183"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0183"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="51"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="386" mass="42322" checksum="74CC02D08C1E09E0" modified="2018-10-10" version="1">MPGLPHFAVDGWMRPGTPRGRRIRPNQPLSQQRERTLSEQIDPRDALTPMVTIEHVSKVFGKGKKAVTAVDDVSLTVNRGEIFAIIGYSGAGKSTLVRLINGLETTTSGTLTVDGFEISGKRDLELQKVRTNIGMIFQQFNLMNSRTVAKNIEFPLKVAGWDKAARKKRVAEMLEFVGLTERANYYPSQLSGGQKQRVGIARALATKPALLLADEATSALDPETTQEVLALLKKVNQELGITVVVITHEMDVVASIANRVAVMENGRVVEEGTVYDVFSSPQTEVAKLFVATTVKQVPTGEDAAELRKNHKGYLVNVEIIEGNQKLGKVLSYLSERRVRFNIVQGGIETLQGKAYGTLTLELLGEVTSIDAVVAELKTVTRVKEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QVT9</accession>
    <name>A0A2Z5QVT9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohistidine phosphatase SixA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86517">
        <property type="protein sequence ID" value="BAV86517"/>
        <property type="gene ID" value="RA11412_0218"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0218"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="201" mass="22636" checksum="F850F260F6BD84E4" modified="2018-10-10" version="1">MTEISSRMKRDVKHLILMRHAEADWGLNDFDRPLTKRGHQQAAQAGAWLAERGYIPEQIMSSAALRTRQTTTWVSDALGEKGPTAHLDEGLYEVGASRIIARINGVSENVRSVLVVSHLPGIQDAAIQLTHPDSDQNAAMEMFYGFPRRPWQCLRCLGSGRFWMGRMRTLLRLKVSSPRFRAWWLGSVRALGLKLLSGRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW03</accession>
    <name>A0A2Z5QW03_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Skin secretory protein xP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86595">
        <property type="protein sequence ID" value="BAV86595"/>
        <property type="gene ID" value="RA11412_0296"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0296"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="327" mass="35006" checksum="A3A9E71D43C6BBE2" modified="2018-10-10" version="1">MAQTPKGWKPTPTWRPDPAWGPVPAGWQLWIEEPTDSADFNDEGTAYEEPMDELPAHVGDDYTLAGDDSVIAPTPQEHAQHSPAAPATGSFPIQEQAGTERTVDTAVSHNAPAHSALEHDTVTAENSNGTEQGQEQKPRTTSFDPLNDDFRMAQATSHPSRAAHAAHYEAERARLQPNGPANTTEPQPGGHPQVVEGQSNGFNGGQAVAGMPENMPQPTSRRAAREQFMAQQAAQEAAEREAAERAAAQQAEQNTTDAKDEQASAASAAHTQPASESTSGPQVAEIAEDTPRHAQPVSGEPTLPEPADFQRESTTASPLQMSWRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW10</accession>
    <name>A0A2Z5QW10_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 10" type="primary">nadE</name>
        <name evidence="10" type="ORF">I6I94_06985</name>
        <name evidence="9" type="ORF">RA11412_0273</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86572">
        <property type="protein sequence ID" value="BAV86572"/>
        <property type="gene ID" value="RA11412_0273"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0273"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="262"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT88289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="278" mass="30561" checksum="EDD31B3BE9B574C9" modified="2018-10-10" version="1">MRELQEKIVAQMGVRPNMTEEQAREEVQRRVQFLCDYAKATGTRGFVLGISGGIDSTLAGRLCQLASEKLNAEGYRAQFMAVRLPYKTQVDEEDAQKALEFIAPDRAVTFNIADAVDGFDTAYTAAVGTPISDFNKGNIKARARMIAQYALAGDPSLLVVGTDHAAESVTGFFTKFGDGGADILPLSGLNKRQNQLLLRVLGASERLWAKPPTADLLDGIPGRTDEDELGITYPQIDDYLEGKEIDPVVAEKLESIYLRSRHKRTVPVGIADTWWHVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QW39</accession>
    <name>A0A2Z5QW39_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_0328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86627">
        <property type="protein sequence ID" value="BAV86627"/>
        <property type="gene ID" value="RA11412_0328"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0328"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008863">
        <property type="entry name" value="Toxic_anion-R_TelA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38432">
        <property type="entry name" value="PTHR38432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05816">
        <property type="entry name" value="TelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="365" mass="40238" checksum="4B26B369CD6B7650" modified="2018-10-10" version="1">MSNGADELAIALNNTDLKSPTLLDTLENTISVYGADTFNGIDVITQRLLNMQELELAPESPQTKASKNLAELRAQINSLDYSAIDGTPGKRGLAKRLLGRGKNKMEAFFYQYATVNRNIEGISKKLKKSTDALVMQQAELVKLRERLQEGMRDLNEKVAVLQQFADMVRAAAEETRLEGDEETARIYTEKVLYVTEQRISDLLTKLEIAGQAYLTSDVVSSNGKELIRGIRRAEDTTLWAYKMTAYIARSLGMQEAVLQQLGALKQTTENAITRNAEMLSSQATRIQQMASQPAIDPQVLEQAHGKVLAALDEISSFRQGAVDAFAQSNQMLRELTADSMRRVERSNAEENAITGGGSARAITGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWH3</accession>
    <name>A0A2Z5QWH3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proton antiporter efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86693">
        <property type="protein sequence ID" value="BAV86693"/>
        <property type="gene ID" value="RA11412_0394"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0394"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="173" mass="17538" checksum="DDACB820319E6E0E" modified="2018-10-10" version="1">MSSGLALGALGYLFVVFFGSRNDLLLMTSFMFLGLSVGAAQTISNDLILSSVPANKAGAASAISETAYEFGTVLGTVVIGGMLTAIYRAQVTVPAGLNADAAHAAGETLGGATAVAGQLPSDLSAELLHSAHAAFDSGVLVTATFSAVLLAVLSVFTYRMLRSAPAELEKAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWH4</accession>
    <name>A0A2Z5QWH4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86752">
        <property type="protein sequence ID" value="BAV86752"/>
        <property type="gene ID" value="RA11412_0453"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0453"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="54" mass="6415" checksum="A6C8D945E737CA03" modified="2018-10-10" version="1">MYLPGMSLNHMTTCVKEDRGEIRVSVQRRLYLPLWGSERNNPIIFCVEKKNGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWQ6</accession>
    <name>A0A2Z5QWQ6_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86842">
        <property type="protein sequence ID" value="BAV86842"/>
        <property type="gene ID" value="RA11412_0543"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0543"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="50" mass="5199" checksum="1D86F920E3D66CCF" modified="2018-10-10" version="1">MSSDGKIKDEGFSGPRNTRNDLSVSGYGAPGAGGVKPLEPRRILKGGVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWU3</accession>
    <name>A0A2Z5QWU3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family phosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">HMP-PP hydrolase Cof</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_05660</name>
        <name evidence="1" type="ORF">RA11412_0608</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86907">
        <property type="protein sequence ID" value="BAV86907"/>
        <property type="gene ID" value="RA11412_0608"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0608"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT88050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="277" mass="29974" checksum="25A737A976A16808" modified="2018-10-10" version="1">MIRLIASDLDGTLIGKDFRFRPRTLHALQAARAAGIQIVFVTGRPSRWLTPIREQTDFDSYAICSNGAVIYHLGADEVEAVNGAPAHAIRSAHELLQPVFPNATYTLETVDTVYIQGPYEGGEVLEGARVVEQHLLGVLDGFAGEQVIKYLVHVPGMDPDILQARVAQTVGELVSVTRGVVGEPLIEMGSKTVNKGYTLAQFAARHGIEAHEVMAFGDMPNDAEMLCWAGRGYAMASGQPALIEKVGRTCPPFGEDGVAQVIEAMLQEHEEAEPRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWW4</accession>
    <name>A0A2Z5QWW4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Butyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86912">
        <property type="protein sequence ID" value="BAV86912"/>
        <property type="gene ID" value="RA11412_0613"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0613"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV86912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="155" mass="16734" checksum="07E7991F71E0D219" modified="2018-10-10" version="1">MPTEDILTKDFAGFLAKITAPFLLVQSAFCLGLAAGALQSAAEHLQVSGGIFKQEFEGLLGTYRTLRDTLLRLAAEPENAQKRDLLQLRLDVSHLATAATHCELQTVGGAGYVAGSPTARRVREVTFLPVQSPTEGHLRYELAKHDHPEGLQAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWX5</accession>
    <name>A0A2Z5QWX5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PLDc_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I6I94_06395</name>
        <name evidence="9" type="ORF">RA11412_0425</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_052186560.1">
        <property type="nucleotide sequence ID" value="NZ_JPVS01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86724">
        <property type="protein sequence ID" value="BAV86724"/>
        <property type="gene ID" value="RA11412_0425"/>
    </dbReference>
    <dbReference type="GeneID" id="32322284"/>
    <dbReference type="KEGG" id="raj:RA11412_0425"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="8">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV86724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT88179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="87" mass="9747" checksum="17FB6B8B68160C58" modified="2018-10-10" version="1">MPSGVLDVLWTAVFLVGIALALYCLLTIHRSPYFSEVQKLKWLLFTLALPFLGPIAWILRSRAEKREAAQRPSPDTQNTQPPSNDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QWY0</accession>
    <name>A0A2Z5QWY0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose-specific IIA component protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Glucose-specific phosphotransferase enzyme IIA component</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">PTS glucose transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">crr</name>
        <name evidence="5" type="ORF">I6I94_05530</name>
        <name evidence="6" type="ORF">NCTC10207_00127</name>
        <name evidence="4" type="ORF">RA11412_0639</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888337.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86938">
        <property type="protein sequence ID" value="BAV86938"/>
        <property type="gene ID" value="RA11412_0639"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0639"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-1" evidence="3">
        <location>
            <begin position="35"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV86938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT88024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VEI22061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="167" mass="17607" checksum="E07A39815020C539" modified="2018-10-10" version="1">MFGFGKKKEAAEQPAAEIYVAPVSGEYLPLAEVSDPVFSQGVMGDGYAVDPTDGVICAPVSGEIALIQDTLHAFMIRTPNGGEVLVHIGIDTVDLGGEGFEGLAKVADKVDAGDPIVKVDWAAIEGRIPSKETMVMITNTAKFNISKESDARRTVQAGDRVAEATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QX73</accession>
    <name>A0A2Z5QX73_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Prephenate dehydratase</fullName>
            <shortName evidence="10">PDT</shortName>
            <ecNumber evidence="3 10">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 14" type="primary">pheA</name>
        <name evidence="14" type="ORF">I6I94_05385</name>
        <name evidence="13" type="ORF">RA11412_0672</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3 10"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86971">
        <property type="protein sequence ID" value="BAV86971"/>
        <property type="gene ID" value="RA11412_0672"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0672"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="11">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="12">
        <location>
            <begin position="205"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="9">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV86971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT90020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="321" mass="34390" checksum="48DC41823B3E4D05" modified="2018-10-10" version="1">MRYTYLGPSGTFTESALLSVPGAVGAKRIPATSVPNALERLRSGDVDAAMVPIENSVEGGVSATLDAIAASEGMRIIREVLVPIRFVLVAARPLAIDEIKTVSTHSHAWAQVRQWADETIPTAEYLPGSSTAAAAVGLLDPSCAYDAAICSPALLATHPNLHVLAEDIGDNKNAVTRFVLISSTADIPDPTGADKTTLTIPLPENREGTPENRSGALLELLEQFASRGVNLSRIESRPTGRQMGSYMFSVDADGHIYEARMRDALRGLHRIAPGIKYLGSYPRADRQPTVAPRIHSENSFDAAHAWVESLFPGGRPAHLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXE2</accession>
    <name>A0A2Z5QXE2_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87117">
        <property type="protein sequence ID" value="BAV87117"/>
        <property type="gene ID" value="RA11412_0818"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0818"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="83"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="285" mass="32784" checksum="7AA2C4C7AAF8F427" modified="2018-10-10" version="1">MTVAAERRYLKQLFRQFDHLKCILEYRAFEKVLDPYDNHSLGEVHVRLAGTAAGKLMEGFIEVARGNTERMLTDALTEKPEEQLVEYNVFTDCSFRSTHNKKYSRGGRMGIAGVSEDGFYFHTHYDAVNIMTGELSAMLTAFHVFYTGGRRLVINTDSLGALTFVLRLAHSRWSFERWAREGIQDERVITEMTRLTEAIRSRRVIVKHVPGHTGHGLQESSDSVSKMHRHFPGQVVDKRHILEFNQRCESIITALSGCDKAVRLPSPEWLYVRPSTIHMGNRLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXF9</accession>
    <name>A0A2Z5QXF9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87061">
        <property type="protein sequence ID" value="BAV87061"/>
        <property type="gene ID" value="RA11412_0762"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0762"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="13"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="99"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="267" mass="28919" checksum="284340D9996C40EA" modified="2018-10-10" version="1">MLSTIEPETLFRVVDIAAVVANGLLGGAVARALRFDMVGFLLLAVVCSMGGGMIRDVLLNAGLPIALTDGWYWVGAITSAALAYVLDLSSNWATRALVVVDFLGMGCWAATGTIKSLTLGLHWLPAIALGVTTAVGGGVIRDIMVNRIPAIFGGNSLYATVAFVGAAETAICFKILERPNVAVAVSVLTCTVLGIVARWRDWRLPMPTTLKVQRPRLLDVFRRDHEHLENEGWAPGTPLTNQLDVITEDQIQAYREQLHREREQRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXI4</accession>
    <name>A0A2Z5QXI4_9MICC</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87158">
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        <property type="gene ID" value="RA11412_0859"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0859"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="123" mass="13452" checksum="30521C0C87B52EDE" modified="2018-10-10" version="1">MRSMLSPESYAKLGKHVRELQMVLANILSAAIAEHYIPENDIRELAMLVHGSLSSSAGRTEDAPDEDTRERQIQSTIRFIQMGLGARFDTDGRPIKLDGAPQAPANAHSDDEPSSESIHLSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXK5</accession>
    <name>A0A2Z5QXK5_9MICC</name>
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        <submittedName>
            <fullName evidence="2">Copper chaperone</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Heavy-metal-associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_05415</name>
        <name evidence="2" type="ORF">RA11412_0665</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004005811.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86964">
        <property type="protein sequence ID" value="BAV86964"/>
        <property type="gene ID" value="RA11412_0665"/>
    </dbReference>
    <dbReference type="GeneID" id="29744391"/>
    <dbReference type="KEGG" id="raj:RA11412_0665"/>
    <dbReference type="Proteomes" id="UP000250241">
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    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT90024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="71" mass="7143" checksum="EB237B69045D4021" modified="2018-10-10" version="1">MAITTVKATGLTCNHCAMSVSEEVGEVPGVTGVNVDVVKDGVSTVTIEHEGTLNTQAVADAIVEAGFTPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXN2</accession>
    <name>A0A2Z5QXN2_9MICC</name>
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        <recommendedName>
            <fullName evidence="2">HipA_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86994">
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        <property type="gene ID" value="RA11412_0695"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016740">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012893">
        <property type="entry name" value="HipA-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07804">
        <property type="entry name" value="HipA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HipA_C" evidence="2">
        <location>
            <begin position="9"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV86994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="138" mass="15886" checksum="3B36512E4AD515DD" modified="2018-10-10" version="1">MSERAASPALAARNIYVQFLYAWLTGNGDLHAKNISLLKTPEKGWHVSPMYDVPNSWVYFKDDMALSVNSRVKNLKKRDWDALAHCAGIPEKMQRSLHKTALKAAAGVLWDRLPFTGSQRYGVERELSHRRWELEKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXQ3</accession>
    <name>A0A2Z5QXQ3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMI1/KNR4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_04285</name>
        <name evidence="2" type="ORF">RA11412_0938</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87237">
        <property type="protein sequence ID" value="BAV87237"/>
        <property type="gene ID" value="RA11412_0938"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0938"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="30"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="187" mass="21226" checksum="044A77363535160A" modified="2018-10-10" version="1">MPIYTPEEYLAVIERIKTKIAQKNISMGPTISETEIAAFESACNTRLPQAYRLFLLEVGDGWNDPAAESISASPIHRLAEIEHKDLSLPMTLTDGWVWEDEEDEEQLSDESFERKLGNQGIELMDEGCGMTYELITAGPCAGEVWSFSDVGVSPCCERQDFLGWFELWIDSDGDPDYFKDYVYEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QXQ7</accession>
    <name>A0A2Z5QXQ7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87222">
        <property type="protein sequence ID" value="BAV87222"/>
        <property type="gene ID" value="RA11412_0923"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0923"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016289408" evidence="1">
        <location>
            <begin position="22"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="77" mass="8267" checksum="3958BF2B111AD6F8" modified="2018-10-10" version="1">MTGTAWAAPLVLSTAVIPAYASSSADDGPCLDPDKSYEIFAKDMRMAAENRAAGEKAMKKLWFPTMPHICALIYSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY01</accession>
    <name>A0A2Z5QY01_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">RA11412_1048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 11412</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87347">
        <property type="protein sequence ID" value="BAV87347"/>
        <property type="gene ID" value="RA11412_1048"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1048"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="252"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="327" mass="34389" checksum="3F11182DA1C18535" modified="2018-10-10" version="1">MAMAAAKLGIKARIYMPLGAALPKITATRDHGAEVELHGTTVDEALAEAKRYAEATGAVFVHPFDNEDIIAGQGTIGLEILEQVPDVDTIIVGVGGGGLLAGLSTAVRAKEAQLGKKIRIIGVQAEHAAAYPLSLAADALVPLKKVSTIADGIAVGRPGQLPFSIIKELVDDVATVSEDDIARALIFLMERNKLVVEPAGSVPVAALMNGKLKEEYGELGTVVCVLSGGNIDPMLMLKVIQRGLSAAGRYMTIKMMLSDRPGELATISRIISENDANVTGVDHTRVGGSLSMGDVSITIDMETNGTEHCNRVISALEEEGFRPIIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY46</accession>
    <name>A0A2Z5QY46_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunits gamma and tau</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87154">
        <property type="protein sequence ID" value="BAV87154"/>
        <property type="gene ID" value="RA11412_0855"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0855"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="210" mass="21860" checksum="EB23FFEA6DE848EC" modified="2018-10-10" version="1">MAGGAHPTGGSGKPRPEPENPKEPGAAEGHPKNTGNTAPNRAAHTQTPTTAASTSMRGEETQNPAKGTTPQQAAQRASQSFTESAYADSPAEYPVLNEHDVPPEDPYFPPAPDPDVHGAGAHSAGDAAVPPLSDPSEEQGPQEPAETPPEDTGQEPQQPFGERDSFASSTPAGVHAEKADEPQENRAEEQEKKKHSVLFPPPSPGRIGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY59</accession>
    <name>A0A2Z5QY59_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_0951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87250">
        <property type="protein sequence ID" value="BAV87250"/>
        <property type="gene ID" value="RA11412_0951"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0951"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="109" mass="11853" checksum="08A729A70A44CAF5" modified="2018-10-10" version="1">MLFTSVGWGNASVSFTGCVFNPSSRNVFTGRGAAQSPVRFSGKLPLGARALEFDELDELQEHRQVLHPTAFVAPASPGPAAEYAHLPHQVSEEAVEEFARWARELIGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY86</accession>
    <name>A0A2Z5QY86_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="11" type="ORF">I6I94_03985</name>
        <name evidence="10" type="ORF">RA11412_1014</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87313">
        <property type="protein sequence ID" value="BAV87313"/>
        <property type="gene ID" value="RA11412_1014"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1014"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
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        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="14"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
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        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
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        <ligand>
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        <ligand>
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        <ligand>
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        <ligand>
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        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="233"/>
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        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
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        <location>
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        <ligand>
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        <ligand>
            <name>pyridoxal 5'-phosphate</name>
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    </feature>
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        <location>
            <position position="234"/>
        </location>
    </feature>
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        <source>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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    <evidence type="ECO:0000259" key="9">
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            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAV87313.1"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="426" mass="46411" checksum="9F0D96DB83A04CDF" modified="2018-10-10" version="1">MTERATVTLEVPLAELDPEVAEALDLERKRQQNTLEMIASENFVPRAVLQGQGSVLTNKYAEGYPGRRYYGGCEFVDIVEDLAIKRVKELFGAEHANVQPHSGAQANNAVMHALLNPGEKIMGLSLAHGGHLSHGMKLNVSGKLYEVVAYEVGDDGRVDMEQVRQLALAERPKVIIAGWSAYPRQLDFAKFREIADEVGAYLWVDMAHFAGLVAAGLHPNPVPHAHVVSSTVHKTLGGPRSGFILCTEELKKKIDSAVFPGQQGGPLMHVIAAKATAFKIAATEEFKDRQKRTIEGARILAERLTRQDMRDAGVSIATDGTDVHLVLVDLRHHELTGKEAEDLLHDAGITVNRNAVPNDPRPPLVTSGLRIGTSALATRGFDAAGFTEVADIIASVLLPQHDIAALRQRVSVLCEKYPLYVGSENW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QY92</accession>
    <name>A0A2Z5QY92_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylyltransferase/cytidyltransferase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Glycerol-3-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tagD</name>
        <name evidence="3" type="ORF">I6I94_03520</name>
        <name evidence="4" type="ORF">NCTC10207_00566</name>
        <name evidence="2" type="ORF">RA11412_1138</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
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    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.39" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888167.1">
        <property type="nucleotide sequence ID" value="NZ_AP017895.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87437">
        <property type="protein sequence ID" value="BAV87437"/>
        <property type="gene ID" value="RA11412_1138"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1138"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047348">
        <property type="term" value="F:glycerol-3-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_trans-like"/>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
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    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VEI22489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="173" mass="19634" checksum="32CC4D4E899374F2" modified="2018-10-10" version="1">MTIGYAAGAYDLFHVGHLNILRQAKANCDHLIAGVVHDDVLEQTKGRRPVIPIEERAEIVSHISYVDEVHIETNPDKLHTWSQKPFDVFFKGDDWKGTEKGIALENRFAEVGVRVHYFPYTEHTSSTKLRKVVDLLEAEHDAIEALGRIMRLLDDEQQHGASIKRGLIAQEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYB3</accession>
    <name>A0A2Z5QYB3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-antigen ligase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I6I94_03495</name>
        <name evidence="4" type="ORF">RA11412_1143</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT90079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87442">
        <property type="protein sequence ID" value="BAV87442"/>
        <property type="gene ID" value="RA11412_1143"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1143"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAV87442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QQT90079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="419" mass="45746" checksum="3F0869B9D964354A" modified="2018-10-10" version="1">MSAGRGLPNNQNAPALPAWPLLTLLYGFPIIWALGLLQIAPIILAFVMLGYMLVRGSVRIYPALWVWGALTFWVVVCAVSLVEPTDLIAWGFRFSGVFCAGVFTLYYFNARAAITPDRLLGGLVTLWVTLVILGWGGVLFPNFRLQTPMSFIMPASILQNPLARDYMLPPLAEVQRPWGAPEAYNRPSAPFPYANSWGLAYTLLTPIMLAYLLRLRNRWAQVGLVVALLLSTVPAVKTSNRGMFIGLGIVVAYVLLRQLFARNWRAVAFGVGVVAVGVIGLFATGTVAEILGRQNYSDSTGGRAALYKSTWEATLQSPIVGYGTPRMEPSVGVSMGTQGYLWTLMFCFGFVGLGLFLVFLSSAVFSGLRVSTASGYWLHAVPVSCFVVLIFYSFDITQLSVLLLSSALCVRSNYYGEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYU3</accession>
    <name>A0A2Z5QYU3_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR-repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87622">
        <property type="protein sequence ID" value="BAV87622"/>
        <property type="gene ID" value="RA11412_1323"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1323"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="304" mass="33539" checksum="A7D54F63EA4C3B2A" modified="2018-10-10" version="1">MSEKPRRTSNASGDNRPMYKGNRTEKSRGKKGGYKGKGFKDNRRDGKGYDRNGASGRGDKKFNRNHQSSQRSSTRRQHSSEDMPQEDVRTIGGRAGYRPSKAKAPEIDNDVTGRELDGATNRQLRALEPRNAETVAKHLVMAGRYLDIDPQFALEHAIAASRSAGRIAAVREAVGVTAYVAEEYETALRELRTHRRISGSNEHLALLVDCERALNRLPKALEMLNEAQREDLPTAVRVELAIVESGIYIDQGKNLRPLLYYVSLSLTLNVPITIAPAYSLLMRLPSLMQGKTGSTAVGTTGPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QYX9</accession>
    <name>A0A2Z5QYX9_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">gcvH</name>
        <name evidence="7" type="ORF">I6I94_02590</name>
        <name evidence="8" type="ORF">NCTC10207_00770</name>
        <name evidence="6" type="ORF">RA11412_1368</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887859.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87667">
        <property type="protein sequence ID" value="BAV87667"/>
        <property type="gene ID" value="RA11412_1368"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1368"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QQT89531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VEI22685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="128" mass="13512" checksum="06493269A9B00557" modified="2018-10-10" version="1">MSNVPAELLYTSDHEWVSALTDEGTVRIGITDHAQDALGDVVYVDLPSEGDTVEANDSFGEIESTKSVSDVLAPVAGEVVAVNEAVNDDSSLVNSDPYGEGWLVELRPANADDLSGLLSAEAYKAELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ18</accession>
    <name>A0A2Z5QZ18_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">mraZ</name>
        <name evidence="11" type="ORF">I6I94_02515</name>
        <name evidence="12" type="ORF">NCTC10207_00785</name>
        <name evidence="10" type="ORF">RA11412_1388</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888897.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87687">
        <property type="protein sequence ID" value="BAV87687"/>
        <property type="gene ID" value="RA11412_1388"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1388"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAV87687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QQT89517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VEI22700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="142" mass="16289" checksum="00D73A6540998E18" modified="2018-10-10" version="1">MFLGTYSPRLDTKGRIILPAKFREELSAGLVLTRGQERCLYVFSAEEFERIHEQMRSAPLSSRQARDYMRVFLSGASDEVPDKQGRVTIPAALREYARLDRELVVIGAGSRAEIWDAQAWDEYLARTEAEFAQLDEEPFPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ27</accession>
    <name>A0A2Z5QZ27_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87735">
        <property type="protein sequence ID" value="BAV87735"/>
        <property type="gene ID" value="RA11412_1436"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1436"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="53"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="243"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="343" mass="37011" checksum="72A6A6E53684DA26" modified="2018-10-10" version="1">MVKAWRPFNGGMPDYVTGFYRPDSFPFEQRQAFAYDFFPAVSPAASDARSALLVWVHGGAWRFGDNHGLRDISRAQGAMRALFQRAGWAVASVNYRYSHQGLFPAPLHDVAEAVRFFRANAAQFGVDAGRIAIAGGSAGGHLAMLCAFAADSAASGFLDAELAEYYLGFGSSAYPDVSASVVCAGSFYGVSDVRTIFSDRPLAGCRLAHRDDDGAEWRLLGSVYPVPADTAADAPARVNWARAHPLDMVRAAGQRCPRVPLFLAHGIADSCVPYQQSVRVFNALKAHGIPTNLVLVPGAEHADPGCFSPRITAQFLEFLQQHMPTDSTETSHGVSVSRLNRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ29</accession>
    <name>A0A2Z5QZ29_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87697">
        <property type="protein sequence ID" value="BAV87697"/>
        <property type="gene ID" value="RA11412_1398"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1398"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="55" mass="5982" checksum="AED76C4DF2754444" modified="2018-10-10" version="1">MKKHAERLRAVLIIGTDSAALMSALATHAGRFLCITSLRVWRTQRMGGCDGSCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZ72</accession>
    <name>A0A2Z5QZ72_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87601">
        <property type="protein sequence ID" value="BAV87601"/>
        <property type="gene ID" value="RA11412_1302"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1302"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="49" mass="5392" checksum="B0883D459FEC4FE5" modified="2018-10-10" version="1">MAAKIRIHDADTGITVANEIDEAEARIREAVPAARVIYLEPDVYRPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZD8</accession>
    <name>A0A2Z5QZD8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">ilvC</name>
        <name evidence="13" type="ORF">I6I94_01930</name>
        <name evidence="14" type="ORF">NCTC10207_00906</name>
        <name evidence="12" type="ORF">RA11412_1533</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI22818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888679.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87832">
        <property type="protein sequence ID" value="BAV87832"/>
        <property type="gene ID" value="RA11412_1533"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1533"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
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        <property type="entry name" value="KARI_C"/>
    </dbReference>
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        <property type="entry name" value="KARI_N"/>
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    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="184"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
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        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV87832.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QQT89412.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VEI22818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="342" mass="36578" checksum="05432E04F7AC28F8" modified="2018-10-10" version="1">MAATIFYNDDADLSLVQGRTVAIIGYGSQGHAHALNLRDSGVKVIVGLAEGSKSRAKAEAEGLRVATVAEAAAEADVIMILTPDQVQAKVYAESIEPNLKPGNALFFAHGFNIRFGYITAPEGVDVAMVAPKGPGHTVRREYEAGRGVPALVAVEKDASGEALALALSYAKALGATRAGVIKTTFTEETESDLFGEQAVLCGSTSQLVQYGFEVLTEAGYQPEIAYFEVLHELKLIVDLMIEGGIAKQRWSISDTAEYGDYVSGPRVISPEVKENMKAVLADIQSGAFAKRFMDDQAAGAPEFKALRAQGESHPIEATGRKLRELFSWNTVDDDYTEGSVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZK1</accession>
    <name>A0A2Z5QZK1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87793">
        <property type="protein sequence ID" value="BAV87793"/>
        <property type="gene ID" value="RA11412_1494"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1494"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="58" mass="6760" checksum="92E37801EE537CCC" modified="2018-10-10" version="1">MTTPSITDEQLKLWYTQRIDPPLPAHWGMPDEVSEFVGEVLWVRFSGVTVIHFPMLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZM9</accession>
    <name>A0A2Z5QZM9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mycothione reductase</fullName>
            <ecNumber evidence="13">1.8.1.15</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="12">NADPH-dependent mycothiol reductase Mtr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I6I94_02565</name>
        <name evidence="12" type="ORF">RA11412_1375</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.15" evidence="13"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87674">
        <property type="protein sequence ID" value="BAV87674"/>
        <property type="gene ID" value="RA11412_1375"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1375"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0274">FAD</keyword>
    <keyword evidence="2 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="11">
        <location>
            <begin position="15"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="10">
        <location>
            <begin position="357"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="186"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="8">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAV87674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QQT89526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="478" mass="52209" checksum="94A5AEABF0D55D1A" modified="2018-10-10" version="1">MSIKDLEVIDGVAQYDLVVIGSGSGNSIIGPEWDDKTVAIIDGGIFGGTCLNVGCIPTKMFVYPATVAVKTQEVAELGVEASVQNISWQNMRDRIFPHRIDKISEAGRQWRANLPNVDFYPEYAHFTGRHTLQTASGRKIHGKQVVIAAGSRATRPDVPGINLPQVLTNDTVMRMEHLPQRMVVLGGGVVAAEFAHVFSALGVEVTQANRSARLLRGVDEEVVNRFAQAASQQWNLLLEHSLIEIRQNDDDSVTVVLENDGELVDVVADKVLVATGRRPNSDSLHAEKFFDVDARGLIGVDEYQRVLYNGAPVEGVFALGDISSPYQLKHVANHEARIVQHNLSHPNELRASDHRFVPAAVFSHPQLAYVGLTEEQARAAGEREGFEVTVKSQEFGDTAYGWAMEDKVGLCKLIARKDTGQLLGAALVGEESSVLIQPLIQAMSFGLGVREMARGQYWIHPALTEVVENALLGLEINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZP7</accession>
    <name>A0A2Z5QZP7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87730">
        <property type="protein sequence ID" value="BAV87730"/>
        <property type="gene ID" value="RA11412_1431"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1431"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043767">
        <property type="entry name" value="DUF5713"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18977">
        <property type="entry name" value="DUF5713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="111" mass="13163" checksum="E433B7414E663F96" modified="2018-10-10" version="1">MKENYAENDDYVYDMRDDDYYPPHLVQKVADELRKFDELLDAGERDPQKIQARADEVTKNINTLADEFDEADSEIETVARESIAETFYLILKEYGLEEDFDIEELIAERDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZQ6</accession>
    <name>A0A2Z5QZQ6_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6493 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87740">
        <property type="protein sequence ID" value="BAV87740"/>
        <property type="gene ID" value="RA11412_1441"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1441"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="198"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="548" mass="61978" checksum="B81B01C9D7BF5455" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZS7</accession>
    <name>A0A2Z5QZS7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CRISPR-associated helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_1567</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87866">
        <property type="protein sequence ID" value="BAV87866"/>
        <property type="gene ID" value="RA11412_1567"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1567"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18019">
        <property type="entry name" value="HD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="5">
        <location>
            <begin position="29"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV87866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="235" mass="25957" checksum="2177A9DC7265D6E6" modified="2018-10-10" version="1">MTVENTKHPSQLATAETSSLWAKTGTDETPSIGLSLPQHMTDAGSVAAELWDKWLSPGAKQRIMKMLNLTQDEAKSFACWVAATHDIGKATPEFAGQLDSRGREELRVFRDRIEEHKFNFPNHLTTPPAGTRCPHSTYSQSILIKLLTEHYTDDAETAGTIASIAGAHHGVPAAYTPGTPGQDFAIFEALNDKWHQAWHELFEMTLEQTGADQVLQKLMSGTKSLLPCSFILRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZU2</accession>
    <name>A0A2Z5QZU2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H oxidoreductase YRKL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87992">
        <property type="protein sequence ID" value="BAV87992"/>
        <property type="gene ID" value="RA11412_1693"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1693"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="172" mass="19044" checksum="247CE09D39A43265" modified="2018-10-10" version="1">MSKILIVSGHPNLPESTANKTALEAVKARFGDAVTVRELDKTRVNGKFDIAAEQKALVEHDVLVLQFPVFWYSVPSLLKQWIDDVFEYGFAYGTDGTALQGKKFLLSATAGAAEDIYQNMLPSELPRPLPTTRTLRRSLVCSCLSRCLATAPRATRVTLRLFMLLVLSTVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZW5</accession>
    <name>A0A2Z5QZW5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87831">
        <property type="protein sequence ID" value="BAV87831"/>
        <property type="gene ID" value="RA11412_1532"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1532"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="60" mass="6410" checksum="709FAB85AA1E0255" modified="2018-10-10" version="1">MRYRAEGLNASSQDAGTSTTRHRIPAPNDSGSTHGCQRLLPPKEGAKCVRSSTAAREKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZW7</accession>
    <name>A0A2Z5QZW7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_1455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87754">
        <property type="protein sequence ID" value="BAV87754"/>
        <property type="gene ID" value="RA11412_1455"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1455"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV87754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="40" mass="4232" checksum="5E2322FE7F7A64FA" modified="2018-10-10" version="1">MTGHGLKDPQWALEPVNGAKVEPTKAAFDVVAVADILDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5QZZ2</accession>
    <name>A0A2Z5QZZ2_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_01000</name>
        <name evidence="2" type="ORF">RA11412_1776</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88075">
        <property type="protein sequence ID" value="BAV88075"/>
        <property type="gene ID" value="RA11412_1776"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1776"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="241" mass="25029" checksum="442688E4F266DD99" modified="2018-10-10" version="1">MMGYSHTVSAAAGWLILAETGMVQVPDTLTLIVTTLACAGAGMLPDIDHHNGSIANSIPPLSRWLARVVGAISGGHRKGTHSLIGLIAFWAIAYFSIQLTYQGVPWVSLILAGFSGGLALRVLGAPGGWIGAIILGYAAYTTGSLSLLPWAISVGATIHLIGDALTTRGILPLYPIILKPPVASALWKKSGYMALPLLGDAGSAREKGLVLLLTLYIGWYAAALGGLIPYPLQTAGLGIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R006</accession>
    <name>A0A2Z5R006_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88062">
        <property type="protein sequence ID" value="BAV88062"/>
        <property type="gene ID" value="RA11412_1763"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1763"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="29"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="155" mass="17469" checksum="748A31819ED08689" modified="2018-10-10" version="1">MMTNNYFKEMIRLADSIADQAHSGQTDKIGRPYITHPRRVAFAVRKLAPENMRVEAQIVALLHDTVEDTGVTLDYLARYFSVSIVDAVDALTKRKGETLEQSIARVRANELARLVKHADIADNTDPERTALLDEETRERLAKKYAKSLTLLSLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R041</accession>
    <name>A0A2Z5R041_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative stomatin/prohibitin-family membrane protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87993">
        <property type="protein sequence ID" value="BAV87993"/>
        <property type="gene ID" value="RA11412_1694"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1694"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="175" mass="19220" checksum="B460EFE67A690D51" modified="2018-10-10" version="1">MVLFRVVDAKDAVLKVENYPIATSQIAQTTLRSLLGRVDLDTLLAHRDDLNADLQSIIDSRTRPWGIKVELVEIKDIEIPEAMQRAMAREAEAERERRAKIISARGELEASSQLKEASDILSASPASLQLRYLQTLLELGADQNSTVVFPLPLDIVGPLMGALKGATGENSTDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R051</accession>
    <name>A0A2Z5R051_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_1545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87844">
        <property type="protein sequence ID" value="BAV87844"/>
        <property type="gene ID" value="RA11412_1545"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1545"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="132" mass="14456" checksum="16F8121453A5BCD9" modified="2018-10-10" version="1">MDEKITVMLVDDQQLVRGGLKMLVDSQPDLQVVMEADDGAAAVDSYARLAEQGHAPNIVLMDVRMPVLDGLQAATRILEMHAPQSHVIMLTTFDLDEYVYSAVRAGASGFLLKDAPPEELLGAVRTVYRGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R095</accession>
    <name>A0A2Z5R095_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FKBP-type peptidyl-prolyl cis-trans isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88138">
        <property type="protein sequence ID" value="BAV88138"/>
        <property type="gene ID" value="RA11412_1839"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1839"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="142" mass="15665" checksum="43BA94FB7F737756" modified="2018-10-10" version="1">MMSSNRDPRVQPSPGAPAKTVSPGTPTNVQVITVKQKINNLVSGKAEAEDPKLPKFTLDEKSGKAEIKLPEDKGEEPKELVSKDLIVGSGEKVKETDNVYARYMGVRWSDGKEFENHYNADSTQPVVGFPLQQVIQGGRRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0D0</accession>
    <name>A0A2Z5R0D0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Excinuclease ABC subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_1702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88001">
        <property type="protein sequence ID" value="BAV88001"/>
        <property type="gene ID" value="RA11412_1702"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1702"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="6">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="8">
        <location>
            <begin position="200"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="437" mass="48842" checksum="79EFE3FF663D2115" modified="2018-10-10" version="1">MVHTATSVEWTVVGSELESLQLEYTWIKEYKPRFNIAFRDDKSYPYLAVTMRDKFPRAQVMRGDRKKGVRYFGPYSQVWAIRETLDALLRVFPVRTCSPGVFKRAEASGRPCLLGYIDKCSAPCVGRISPEEHRNLADGLCRFMAGGAEKFIAELTTDMKDAAANMDFERAAVLRDDIVALTKAFERNAVVLSDSTDADLFAFVQDELEAAVQVFFVRGGRIRGQRGWIVEKVNDGSEGELIEQLLVRLYGEAAAHVASASSTLAEETDANRHEIPRQILVPVLPDNTEQLREWLSGVRGAKVSIAVPQRGDKAELMKTVAENARHSLALHKSRRAGDITTRSASLVELQEALELPEPLMRIECYDISHVQGTNVVASMVVFEDGLPAKSAYRKFSVSGDAARDDTASMYDVITRRFKRYLTEQQQRAQAGPQRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0G5</accession>
    <name>A0A2Z5R0G5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatD</name>
        <name evidence="3" type="ORF">RA11412_1918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with MurT.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobB/CobQ family. GatD subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88217">
        <property type="protein sequence ID" value="BAV88217"/>
        <property type="gene ID" value="RA11412_1918"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1918"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02213">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043702">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase_3" evidence="2">
        <location>
            <begin position="21"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="219" mass="23493" checksum="D04953C04A9468F2" modified="2018-10-10" version="1">MTHTIAGTPAAGPNNGKTLRILQLYPKDMNIYGDWGNTLSLARRAHAHGFDVDIIDYNPGDEFPQDVDIIIGGGGQDSGQTVIQEDLHANSEHLKQLAEDGTPMLVICGLYQLFGKEFRTREGEVLKGIGIFDAHTVGGDERLIGNIVEESKDFGTIIGFENHSGLTYLGSGCTPLAATVTKGEGNNKAETHEGARVHNVIGTYLHGSLLPKTPKSLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0G9</accession>
    <name>A0A2Z5R0G9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">UspA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_00805</name>
        <name evidence="2" type="ORF">RA11412_1824</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88123">
        <property type="protein sequence ID" value="BAV88123"/>
        <property type="gene ID" value="RA11412_1824"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1824"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="296" mass="31759" checksum="BDA20F03486B2092" modified="2018-10-10" version="1">MKYVVGYSPDARGRAALNLGTVLARSLGAELNVVYVIKPQNPRLAAPKSNFGDLLQEQAVGWLEEAQYLVPTDVKARFHLRRADSAVAGLMELAGAIDAGLIIVGGGNSGNWLWHSLGAVGNALLHRSRVPVALAPRDYSADHVINQIDCAISPDIDSINLVEEAIATQNRTGLPVRLVSLYEQNGAADDELYRASIEDLVEQSNVAPHNPQQLSIAVGAGTTIVEAVDSVHWDENAILMAGSSKLAQRGELFLSSTTAKIMTKLPIPLVVVPRDYHPGRKGSQQQPWTGSIPVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0H1</accession>
    <name>A0A2Z5R0H1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heme o synthase</fullName>
            <ecNumber evidence="3">2.5.1.141</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_1752</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88051">
        <property type="protein sequence ID" value="BAV88051"/>
        <property type="gene ID" value="RA11412_1752"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1752"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="232" mass="25561" checksum="779022F995AC9F7C" modified="2018-10-10" version="1">MKRTEKRPLVTGELSDREAIVFAWVLAVVSVAYLWFMVNPLSGVLGVVAILLYVVFYSLYLKKRTTQNIVWGGIAGCMPVFIAWAAVRETIEWPALVLFTVIFLWTPPHYWPLSMKYAEDYKAAGVPMLGAIAPAHSVSVQVVLYGWAMVICSLLLVPVGGAGWVYGLSAAAVGAWFLYQCHKLHLLALAQKATSRTAMVVFHGSITYLTILFIALAIDPFVGGPIMESFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0I8</accession>
    <name>A0A2Z5R0I8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_1939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88238">
        <property type="protein sequence ID" value="BAV88238"/>
        <property type="gene ID" value="RA11412_1939"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1939"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Era-type G" evidence="4">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="86" mass="9279" checksum="AD6DB9295A4CA92A" modified="2018-10-10" version="1">MDIDLTAPLPSYPEGFRSGFASLVGRPNAGKSTLTNALVGQKVAITSNRPQTTRHTIRGIVHKDDYQLILIDTPGIHRPRTLLGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0L4</accession>
    <name>A0A2Z5R0L4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="4">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nrdF</name>
        <name evidence="9" type="synonym">nrdF2</name>
        <name evidence="8" type="ORF">I6I94_00215</name>
        <name evidence="9" type="ORF">NCTC10207_01262</name>
        <name evidence="7" type="ORF">RA11412_1978</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="4 6">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006887238.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88277">
        <property type="protein sequence ID" value="BAV88277"/>
        <property type="gene ID" value="RA11412_1978"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1978"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026494">
        <property type="entry name" value="RNR_NrdF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04171">
        <property type="entry name" value="RNR_1b_NrdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88277.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QQT89105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VEI23165.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="325" mass="37048" checksum="275B214FB5935EDF" modified="2018-10-10" version="1">MSEKVHLVDHPIEAINWNRLEDEKDLEVWDRLTGNFWLPEKVPLSNDVPTWKTLTAEEKELTMRVFTGLTLLDTIQGTVGAVSLLPDAVTAHEEAVYTNIAFMESVHAKSYSSIFSTLCSTKEIDEAFRWASENEYLQKKAKIILAYYIGDDPLKKKVASTLLESFLFYSGFYLPMYWSAHAKLTNTADLIRLIIRDEAVHGYYIGYKFQRGLAKETPERQAELKEYTFNLLYELYENEVAYTHSLYDGVGWSEDVKKFLHYNANKALMNLGYEAMFPASVTNVSPAILSALSPNADENHDFFSGSGSSYVIGKAVNTEDEDWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0N4</accession>
    <name>A0A2Z5R0N4_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease H</fullName>
            <ecNumber evidence="5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_0130</name>
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    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86429">
        <property type="protein sequence ID" value="BAV86429"/>
        <property type="gene ID" value="RA11412_0130"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0130"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
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        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV86429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="144" mass="15334" checksum="21D8E56EDA40785A" modified="2018-10-10" version="1">MGELKAVLDLFEATAHMPERKLVVYCDSQYVINSLTKWMPGWKSRGWKKADGKPVLNRELLQELDAATAGRDYQLVWVKGHSGHELNEAADARANAAAQAYQQGNAPDAGPGFGAAAGASSGASDGQAPAAEAEPEQGPQQMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0N9</accession>
    <name>A0A2Z5R0N9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Vitamin K epoxide reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I6I94_00085</name>
        <name evidence="13" type="ORF">RA11412_2008</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88307">
        <property type="protein sequence ID" value="BAV88307"/>
        <property type="gene ID" value="RA11412_2008"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2008"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12922">
        <property type="entry name" value="VKOR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041714">
        <property type="entry name" value="VKOR_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="VKc" evidence="12">
        <location>
            <begin position="30"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV88307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QQT89083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="218" mass="24122" checksum="0474D6ACEF52F411" modified="2018-10-10" version="1">MSVEQGTQEHNEDTLSASGSADSLEPQSSERSLAVWLMVTATVALASSAMLVHERLQIFIDAGHSSLCDINALLNCGTVMRTPQAELFGFPNPFIGLVAFPILMTIAMGTLAGARYKKWFWLATNAGLGAAVVFVLWLWFETTFVINALCLFCMIVWVMTIIMFVKVTIRNIVEGVIPASEQVRQSATGWTWFSILLLVLLIFGIIIIRFFNVFMGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0P0</accession>
    <name>A0A2Z5R0P0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF308 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_11220</name>
        <name evidence="2" type="ORF">RA11412_2056</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88355">
        <property type="protein sequence ID" value="BAV88355"/>
        <property type="gene ID" value="RA11412_2056"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2056"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT89052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="190" mass="20357" checksum="A6F74C0A9F03C109" modified="2018-10-10" version="1">MRTKRHWFSLVAGIFFLACSIFMFANPSAPLTALGIFFSIIVFIGGVLETIRYFFTPASTRSVWSLISAIITVLVGVLLLSASAAAQAAFIPVIVGVWMMIVGLSRLSAGRRATYLSSGAGKHMVFSGVVPLILGILICLFPVVFGSVVVWLIALALLLVGVVCIGDFFVSRKANRPGPYDDGIIDVEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0R4</accession>
    <name>A0A2Z5R0R4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_0160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV86459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV86459">
        <property type="protein sequence ID" value="BAV86459"/>
        <property type="gene ID" value="RA11412_0160"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0160"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV86459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="125" mass="13912" checksum="2CEB920AC7643A53" modified="2018-10-10" version="1">MADERNRPTGDGSEPHDNPHTTPRPKRYEPHAHPMPAVSLNQVNDAQLRDALAHSSRSSRKALYEVAQAHGVETSTEQTQLLPVDEAGMPTVSIDDELVPEPMPGETTPNPLTWLRPTRPHARFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0R5</accession>
    <name>A0A2Z5R0R5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I6I94_00970</name>
        <name evidence="5" type="ORF">RA11412_1782</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88081">
        <property type="protein sequence ID" value="BAV88081"/>
        <property type="gene ID" value="RA11412_1782"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1782"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QQT89242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="261" mass="28025" checksum="148B01446773B7FC" modified="2018-10-10" version="1">MSTVLNLHNVNVVRGGRNILRDVSWSVNEGERWVVLGPNGAGKSTLLSIAAARLHPSGGEVEILDETLGAVDVFELRPRIGISSAASATQIPGHEKVSDVVVTAAYAVSGRWKEEYEAMDDARATELLADWGVETLAERTFGSLSDGERKRTLIARALMTDPELLLLDEPGAGMDISGREDLVERLSALAADPYAPATVLITHHLEEIPAGFTHALLLREGQLVAAGPIAQTITEENLARTYGMDLALTTTATGRYSAFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0S8</accession>
    <name>A0A2Z5R0S8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I6I94_00920</name>
        <name evidence="1" type="ORF">RA11412_1795</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023133090.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88094">
        <property type="protein sequence ID" value="BAV88094"/>
        <property type="gene ID" value="RA11412_1795"/>
    </dbReference>
    <dbReference type="GeneID" id="32321761"/>
    <dbReference type="KEGG" id="raj:RA11412_1795"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QQT89233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="93" mass="10640" checksum="E4FFA28BDA17B8F0" modified="2018-10-10" version="1">MNNNPHTELDRLITALKNHLTAVTNRNGEHDPAIDEAYVEIANAFETYENALFEEHNEVTPLAVYGDDDDEDLEELLTNDDNTFTPEDDIDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R0W1</accession>
    <name>A0A2Z5R0W1_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="4">UPRTase</shortName>
                <ecNumber evidence="4">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">pyrR</name>
        <name evidence="7" type="ORF">I6I94_00580</name>
        <name evidence="6" type="ORF">RA11412_1881</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
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            <begin position="22"/>
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    </evidence>
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    <sequence length="204" mass="22266" checksum="108862046BA4A72F" modified="2018-10-10" version="1">MNGTGVPAGSSAHNTSNVGRTILNDDEIRRALTRIAFEILESNKGTDHLVLIGIRSRGYPLARRLAQRIQANDSNFDLEDGLGALDITPYRDDLTDEEYENRSAGESLIPAGGLDGKHVVLVDDVLYSGRTVRAALDALNEYGRPALVRLAVLVDRGHRQLPIRADHVGKNLPTSAAEKVRVVLEETDHATDRVDIIQLEGQLS</sequence>
</entry>
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
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            <authorList>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="Proteomes" id="UP000250241"/>
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    </evidence>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="109" mass="12115" checksum="5C6F23A09F38CABA" modified="2018-10-10" version="1">MQTASATTAANEHDDERKIIETLIEERNRELTEKGAPTLQVRSLTKVEHKGDTLALTAEVQAPGYTPTEAELRDKGVRMQDGMAVQKVTFELHQDNGRWRIASAVPVSE</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3 5" key="2">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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    </dbReference>
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    <dbReference type="GeneID" id="32322848"/>
    <dbReference type="KEGG" id="raj:RA11412_2219"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="69" mass="7434" checksum="7C28D5F11457065B" modified="2018-10-10" version="1">MTVNSTLDPAKVRQLTSRDRCDVCGAQAYVRAVLPSGHDLLFCGHHARANEAGVKAIAGTTWDDQTSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1G4</accession>
    <name>A0A2Z5R1G4_9MICC</name>
    <protein>
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            <fullName evidence="9">Type II secretion system F family protein</fullName>
        </submittedName>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_10330</name>
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    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
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    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88577">
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        <property type="gene ID" value="RA11412_2278"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2278"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="176"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="311" mass="34286" checksum="B8B9BF9DB01F7D70" modified="2018-10-10" version="1">MRSLYILLGLLLGSGLWLVISTFVRSRRSGFAERIAPQMRSVTVRESLSRETEETPTSLGAVLLVFFGPMLDRISSRMRNSSMTDESLRERLRRAGEDENVSKFRAEQLLWALAGVGMMSALTVIGVIQERISVPAGIVLIAVCGVSGFMARDWWLGERIKKREKMLITEFPALAELMALSVTAGESALGALERICRTSNGELSREFSDILAQTRTGSGLLPALYDFARRTQVPALNRFVDGVAVAIERGTRLADVLRAQAQDARDNAKRELMETAGKKEIAMLAPVVFFILPLTVVFAIFPGLSLLHLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1H1</accession>
    <name>A0A2Z5R1H1_9MICC</name>
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        <submittedName>
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            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88512">
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        <property type="gene ID" value="RA11412_2213"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2213"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="139" mass="15894" checksum="27E7C90A3108DA27" modified="2018-10-10" version="1">MARILKTLPEWFGREESNAEYIHAAERLETWTVTHPETHEVVGIMLIAQHYPVEAEIHLLAVDAAFHGYGIGTSLINAFEKEARNRGIRLIQVKTLGESFLNEPYQRTRNFYQAVGFLPLEETNLWGEDTPCLIMVKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1I4</accession>
    <name>A0A2Z5R1I4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_10055</name>
        <name evidence="2" type="ORF">RA11412_2346</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88645">
        <property type="protein sequence ID" value="BAV88645"/>
        <property type="gene ID" value="RA11412_2346"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2346"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="228" mass="25715" checksum="85668C4F4262BB19" modified="2018-10-10" version="1">MLDVFLWILVIAGGVCGIVVTHLTYLLVRGANEKKNAPLRVRFYSWGKVALFEVLIGVVVAGVSSGFIAISSSLKKSDPLWTVLPYVFLVMFFSAFAVSIWRMTVPYYEFTPSALIVRTTGSGVRSLELSQISGYQYYPYRANRDGGGSDYLEIYDAKGSVFYKISVLRQNAPNVLGARIVFRAQHGRWAREDDPRDQQILAQLTHRETVKYLMQHMVRDDFLTLKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1K9</accession>
    <name>A0A2Z5R1K9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC iron siderophore transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88406">
        <property type="protein sequence ID" value="BAV88406"/>
        <property type="gene ID" value="RA11412_2107"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2107"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="66"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="546" mass="58977" checksum="560B2715D6CF5DD2" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1L4</accession>
    <name>A0A2Z5R1L4_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metal ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Zinc ABC transporter inner membrane permease protein ZnuB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I6I94_10455</name>
        <name evidence="8" type="ORF">RA11412_2253</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Rothia aeria</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88552">
        <property type="protein sequence ID" value="BAV88552"/>
        <property type="gene ID" value="RA11412_2253"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2253"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QQT88922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="311" mass="32401" checksum="DAAED216B1745C92" modified="2018-10-10" version="1">MMHVLAAASSTQQGDLLSRIFVFERYGELVQLLQNSILAGAVLGIIGGFVGVFVMMRDHAFAVHGISEMSFAGAALALLLGYDVVTGSMVGSIVSALLIGILGVKKHDSNSVIGALMPFGLGLGILFLSLYQGRSANKFSLLTGQIVSVDADQLGNMIGGAIVIITILVLVWRPLSFASLDPEVAHAKGVPMRALSLVFMVVLGIAVALSVQVVGSLLVLALLITPAAAAMQVTASPLRTLLLSVLFAEAAIVGGILLALAGSLPISPYVTSVSFFIYIVCRVIGAIMRRHSASGRLVAEDTDAHHHPAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1M7</accession>
    <name>A0A2Z5R1M7_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88695">
        <property type="protein sequence ID" value="BAV88695"/>
        <property type="gene ID" value="RA11412_2396"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2396"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="123" mass="13826" checksum="518EFE9D25A483B8" modified="2018-10-10" version="1">MTITNPTTTGAWSALTQHKASLTPNLRAWFEQDPSRAQKFSFDAADLHVDLSKNLITEETVQLLLKLAKEVNLAERRDAMFTGEHINVTEDRAVLHTALRRPKGYSPPSLLMGRMSIAMFTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R1V9</accession>
    <name>A0A2Z5R1V9_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_2162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88461">
        <property type="protein sequence ID" value="BAV88461"/>
        <property type="gene ID" value="RA11412_2162"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2162"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="138"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="200" mass="22802" checksum="ED59179927166228" modified="2018-10-10" version="1">MTSAYQEAQKTAQIPQEYQRLAALMECAAAGNEHCFEALYDALVPRLYALINRILHNRTHAEEVTQEVFLEIWQKAPLYRAERGAVLSWAATIAHRRAVDRVRSVAASAERDFTRGLEEYRESYHHVDDALAAFMDTEEVHHALSGIPREQAQLLTMAYFGGKSQREISDETGIPLGTVKTRMRAGMQKLRERLEGTRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R244</accession>
    <name>A0A2Z5R244_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate aminotransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Pyridoxal phosphate-dependent aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_09550</name>
        <name evidence="2" type="ORF">RA11412_2464</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88763">
        <property type="protein sequence ID" value="BAV88763"/>
        <property type="gene ID" value="RA11412_2464"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2464"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="64"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="407" mass="45608" checksum="F6427E926A2BBF54" modified="2018-10-10" version="1">MTKYRQSSKLNNVLYDIRGPILEEANRMEAMGHRILKLNIGNTAPFGFEAPDAIMMDIIRHLPVTQGYSDSRGLYSARTAIVQHYQNRGILDLEPNDVYLGNGVSELIPMTLQALCETDDEILVPMPDYPLWTASVALSGGKPVHYLCDEENNWYPDLEDIKSKITSRTKGIVVINPNNPTGSVYPRHILQQIVDVAREHELVVFTDEIYEKIIYDGAEAINLATLTGDDVLCLTFSGLSKAYRVCGYRAGWVAITGPKHEAANYIEGITLLASMRLCSNVPAQHAIQTALGGYQSIDALVAPGGRLHEQRDVAYRMLNEIDGISCNQSDGALYLFPKVDTEKFNIVDDEKFMLDLLKEQKILFSHGGAFNWHKPDHFRLVFLPDVQTLTDALNRLGEFLSDYKQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R247</accession>
    <name>A0A2Z5R247_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">RA11412_2526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88825">
        <property type="protein sequence ID" value="BAV88825"/>
        <property type="gene ID" value="RA11412_2526"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2526"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SIS" evidence="6">
        <location>
            <begin position="79"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="6">
        <location>
            <begin position="252"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="407" mass="44163" checksum="4450F0E9020E577C" modified="2018-10-10" version="1">MGQDQIVTITSTDYSIIDFDGNPAEGKPFHIEWDAAAAEKGGYNSFMEKEIHEQPTAVEQTLMGRMDEKGNLVLDELNIDDSVLRSIDKIIVVACGTAAYAGQVARYAIEHWCRIPTEVELAHEFRYRDPIVNEKTLIVALSQSGETMDTLMAVRHAREQGAKVISICNTHGSTLPRESDAALYTHAGPEIAVASTKAFLAQITAAYLLGLYLAQLRGNKYKDEISAILGELQKMPAKIQKVIDNDTLVKELGAEMKDTSSVIFLGRHVGFPVALEGALKLKEISYIHAEGFAAGELKHGPIALIEEGQPVIIIVPSAQGRESLHGKVVSNIQEVRARGAFTIVIAEEGDEAVKDYADRLITVPAAPSLLQPLLATVPLQIFACALAEAKGLDVDQPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R248</accession>
    <name>A0A2Z5R248_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mg/Co/Ni transporter MgtE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88672">
        <property type="protein sequence ID" value="BAV88672"/>
        <property type="gene ID" value="RA11412_2373"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2373"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV88672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="51" mass="5619" checksum="BD4749EFE75AF7FF" modified="2018-10-10" version="1">MPPSESIGRILDTDTEPVSDQASLEELARVLATYDLTIIPIVNESHRLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R267</accession>
    <name>A0A2Z5R267_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-inositol 3-phosphate glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">RA11412_2519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88818">
        <property type="protein sequence ID" value="BAV88818"/>
        <property type="gene ID" value="RA11412_2519"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2519"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="203"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAV88818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="387" mass="41149" checksum="C3B44E3F3E0894D0" modified="2018-10-10" version="1">MNVYIARSVEAMLAADPALRIEVFTLDFGDGASERSPTPEHPRCRVHYVPVSGTRGATKNDLPKFTGGFAQAAVEAAQWAPQLIHAHYWLSGVAALNAAAHYATATAGSRTNVPVLFTPHTTAAAKDAHRGANEPAEPGYRRAEEGRIIAEANLIIANTPVEADQLQGYYGADPSRLRVITPGVDTSIFCPVAGVHAENEGSDTRSRIVFAGRPQPLKGPHLLVEALGLLPDDLLVELDIIGRSDSDYEQLLLQRAAQLQVADRVHLRPPVPASELAQIFRRADIVASPSSSESFGLVALEAQAAGAAVLASDVDGLRYAVENHVSGLLVAPRTPQHWAGAIERVVRAPRLRLTLGAQAAARARSFSWEATALKTLAAYADALSAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R279</accession>
    <name>A0A2Z5R279_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I6I94_10060</name>
        <name evidence="2" type="ORF">RA11412_2345</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88644">
        <property type="protein sequence ID" value="BAV88644"/>
        <property type="gene ID" value="RA11412_2345"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2345"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV88644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QQT88853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="229" mass="26334" checksum="9AF3076021D2A373" modified="2018-10-10" version="1">MLEALGHYNYLGTGILTAIIVLHFVYLLIRNQREKTTAPWRARTPLWLCAIIEAVLWVIGSFIVGVGLMIMDPTKRIGTGVTMIGFIPIGFVALVTLITLWALTIPYHEITSNAVVVRNFFGFKQSLELSEIGGYLYTRTLRSSHSDNGTTRYHLEDRLEIQTKEGKRFMGVRIYRSPTKNYLGPLMMVRAEEGRWLDVKNPMDRQLMKHMTRRGTLEYLLENSYRGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2B1</accession>
    <name>A0A2Z5R2B1_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfur carrier protein adenylyltransferase ThiF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">RA11412_2598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88897">
        <property type="protein sequence ID" value="BAV88897"/>
        <property type="gene ID" value="RA11412_2598"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2598"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="309"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAV88897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="403" mass="43427" checksum="3D90BDA6F739ACE9" modified="2018-10-10" version="1">MSFIPDPETAPEPSTRLSAAERAFYARQLILPEIGMAGQLKLKAARVAVLGAGGLGAPALLYLAGAGVGEIIIIDDDSIEISNLHRQVIHSYARAGNSKAESAAETMRALNPFITVTVIRERLTDSNALTLLTGTDAVLDGSDNFEARYAVSAAVQQLGIPHIWAAILGFDAQLSVFWPGRGPVYEDLYPQAPAPGSVPSCSTAGIIGALAGVVGSAMAMETIKVITGSGKPLVGEVGLYSGLSGEWKYIPLLANTQALPQKNAESHSERRKEPENRVTFRNNLVFLDTVSEDSTRSDISAAELQDVISRQKVVVIDVRERVEFEAYAIDNAVNFPLTDILSRARKGSLSAKLREKIAPETNLVVIYCTGYTRSVEAAREITPSHRLQFAFYRVVFRAGLRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2C8</accession>
    <name>A0A2Z5R2C8_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsH</name>
        <name evidence="8" type="ORF">I6I94_09170</name>
        <name evidence="9" type="ORF">NCTC10207_01767</name>
        <name evidence="7" type="ORF">RA11412_2554</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006888793.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88853">
        <property type="protein sequence ID" value="BAV88853"/>
        <property type="gene ID" value="RA11412_2554"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2554"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VEI23847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="132" mass="14241" checksum="68DD35E151E53943" modified="2018-10-10" version="1">MTMTDPVADMLTRLRNANSAYHDTVSMPYSKLKARIAEILKAEGYIADVKEEEAKVGKTLTLVLKYGPSRERSIAGVRRISKPGLRTYAKSTNLPKVLGGLGTAILSTSSGLLTDKQAAKKGVGGEVIAYIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2N5</accession>
    <name>A0A2Z5R2N5_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-succinylbenzoic acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89027">
        <property type="protein sequence ID" value="BAV89027"/>
        <property type="gene ID" value="RA11412_2728"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2728"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="59"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV89027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="350" mass="36124" checksum="227C42DF6F2D2864" modified="2018-10-10" version="1">MDSGEAGAMTGAFPGSLTPLPAPRQDALHPHAVILSADEPANPQEILRAFERSLTGDLPNSARNGQDPLGQTEDPESIALVVGTSGSTGAPKQTALSVRALRASARATERFFADYPSAGSAKPQRATSEVPAQWLLALPAHYVAGAQVLARSVLAGTTPVVAASITDGVSFTPEVFLNAAERLSCARRFVSLVPTQVHKLLEAAEASPALGSEIYDALGQFTGILLGGAPASASLLAAARELGLNVVTTYGSAETAGGCVYSGVALPGVRLRVVPEDAGLADSPVVAGAEAAGRIWLGGEHLASGYLGDSARTASHFFVDAHGCRWYRTDDYGSLVPPPQTLPRTVVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2Q8</accession>
    <name>A0A2Z5R2Q8_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polar amino acid ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_2684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88983">
        <property type="protein sequence ID" value="BAV88983"/>
        <property type="gene ID" value="RA11412_2684"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2684"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="29"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="236" mass="25514" checksum="7FBE2B079AE1750B" modified="2018-10-10" version="1">MADWNTLTKQVFNLDIAAKQFPGIITVALKNTLIYTALGFAVGLSGGLLLALMRISSIAPYRWLATLYVEIFRGIPALLVFFAFGYGIPLAFKIRFVDNLIPVTLSLGVVSAAYISEVLRAGLQAVPKGQYEAARSLGMSHTRAMVSITVPQAFRIVLPPLTNEVILLTKDSSLVYLLGVTVSQYELAKFGREGITAGGAGLTPLVVAGLCYLIITVPLGQLSAYFEKRTQARSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R2X7</accession>
    <name>A0A2Z5R2X7_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3 5">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">moaC</name>
        <name evidence="8" type="ORF">I6I94_08980</name>
        <name evidence="9" type="ORF">NCTC10207_01807</name>
        <name evidence="7" type="ORF">RA11412_2601</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaC family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88900">
        <property type="protein sequence ID" value="BAV88900"/>
        <property type="gene ID" value="RA11412_2601"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2601"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="6">
        <location>
            <begin position="28"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="124"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAV88900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QQT88645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VEI23927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="171" mass="18226" checksum="2CDCFC565724DC94" modified="2018-10-10" version="1">MTEKNLHPDAAQPAQDLTHVRADGSAHMVDVTMKDVTTRTALAEGTVHTRADVIAKIFDADLPKGDALPVARVAGIMGAKRTPDIIPLCHPLPLGKITLDFERGEDSVRIVASVKTRGVTGVEMEALTAVSTAALTIFDMIKAVDKYAVISNIRVLEKSGGKSGDWAVTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R305</accession>
    <name>A0A2Z5R305_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">RA11412_0980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 11412</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87279">
        <property type="protein sequence ID" value="BAV87279"/>
        <property type="gene ID" value="RA11412_0980"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_0980"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="8">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV87279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="133" mass="14898" checksum="F485BBBE5C3B51B3" modified="2018-10-10" version="1">MTRAMMIIGAFALVIGLSLYTLLDAARTPAADARTLPKWLWIIVIIFFPVVGPVFWLFFGRARSEKSAAEQPPAADTGRGLKGRRGAVPPAPKAPDDDEEYLRWLKAKAERQKRDRQRQESRDDATDDTDGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R330</accession>
    <name>A0A2Z5R330_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">RA11412_2665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88964">
        <property type="protein sequence ID" value="BAV88964"/>
        <property type="gene ID" value="RA11412_2665"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2665"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018650">
        <property type="entry name" value="STSV1_Orf64"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09852">
        <property type="entry name" value="DUF2079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV88964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="526" mass="58209" checksum="136603A64F13073A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R344</accession>
    <name>A0A2Z5R344_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I6I94_08975</name>
        <name evidence="9" type="ORF">RA11412_2602</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT88644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88901">
        <property type="protein sequence ID" value="BAV88901"/>
        <property type="gene ID" value="RA11412_2602"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2602"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="198"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT88644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="459" mass="49926" checksum="2C2F15D71369B631" modified="2018-10-10" version="1">MHKPQFDGTPSTEEYRAYLALLLRDTFIGRAENLPLARATNRILAQDVLARLDVPSFDNSQMDGYALTAEGASRENRIFTVGREIPAGRPLQRSRASDDLTYPIMTGAPIPKGYVAVVPVEHSERIEYPDVPESFGRPSEKIRLPQAPKGQFIRRRGEDVVAGQVLARAGERVTPALLGTLAAQGYTRVTVACGPRVLVCTGGDEVRPTLTEDGDDTATDLAYGQIYDANGPMLTSMLVEDGAVVRRISIGDDPELLIEHLREEYETFAPDIIITSGGISHGKYEVVRNAIAIAPSLGLPIPLSWFGHVSQQPGGPQGVNVLDFNGHRLPMISFPGNPVSTLISYVLMLRPYLRAGGPYGTPHEVASRMATLDNAPRGVLVIDKPLTAPANKRQFLRGNLTMVESEPGTYQVELYPDVLPGSHLLHHAATADVLIELAPGTTYTGGEAVRYHRIRLTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R399</accession>
    <name>A0A2Z5R399_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">RA11412_2707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV89006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV89006">
        <property type="protein sequence ID" value="BAV89006"/>
        <property type="gene ID" value="RA11412_2707"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2707"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAV89006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="379" mass="42171" checksum="C3F5304A5C9FED85" modified="2018-10-10" version="1">MEQLAHGALAERRAAVDTLVGLADGYLADTSLDENTRNTNAQHIINRLCEYIRSPYALAGEYDVLTRTPVRELPAEQEPTRYRADRDALAQEAQVRGHILGSIHERVQYLRRAESDTPQEALEALRPGRWSHLTFDFTGADFFYPAYLSESYWGAGATFTGCTYRDKARTDGSVYCTDADFSGSTYQKEADFSECKFLGTARFTQSTYNELAFFSGAIFAGDAHLSGCTYVGVFFQGCFFFGQVNLSECVYDGPAQLEMNYYSQAVDFSGCTYNDCADFYECLHGGPVTFTKSVCGEATNFGGSIYLGGADFSGTRFSTKPYFEGTVFADGTVNRFLDSAPNTPPDGARWVSGEEYTQWQQQRELIEEVSSIRQVHNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3G0</accession>
    <name>A0A2Z5R3G0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I6I94_02965</name>
        <name evidence="3" type="ORF">RA11412_1280</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FDAARGOS_1137</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87579">
        <property type="protein sequence ID" value="BAV87579"/>
        <property type="gene ID" value="RA11412_1280"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1280"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="22"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAV87579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QQT89590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="385" mass="43109" checksum="4B37EADCE14D9A84" modified="2018-10-10" version="1">MTTLEAHSPPTLRDALLSRENSLNFIRLMLAVAVIISHAPYLVLGVEVTSAIPVLNLSHLLGDYAVNMFFCISGFLIAHSAQRGTFGGYLKRRILRIFPAYWASILFVVCIGAPLANYTAHSGSPWTAQGALEYVGHNFDLFFLQYSLFDGPSHLPYENSWNGSAWTLSYEFLGYLVLIPIFYLPALKRNSHRVVPMVYLLSLLPFFIFTAAGATNNTFWEVARLYPMFFAGALLYVWGNKIRLHPQAALACFLVPFALQFVAPSVVLQLIQPAYAYGILALGALIRVPLCRRNDISYGMYIYAWPVQVILLMLGSEPLGWVLNALLTIVVTVPIAWFSWRYIEKPAMALKHWQLIPTKPVDRQTEAGGTEAHPVLVQVSTPQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3P5</accession>
    <name>A0A2Z5R3P5_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argS</name>
        <name evidence="13" type="ORF">RA11412_1450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 11412</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87749">
        <property type="protein sequence ID" value="BAV87749"/>
        <property type="gene ID" value="RA11412_1450"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1450"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="432"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAV87749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="605" mass="65952" checksum="F22FB22D4838BE59" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R3Q0</accession>
    <name>A0A2Z5R3Q0_9MICC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">RA11412_1480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 11412</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV87779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV87779">
        <property type="protein sequence ID" value="BAV87779"/>
        <property type="gene ID" value="RA11412_1480"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1480"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAV87779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="105" mass="12280" checksum="1D76C77F84788DD9" modified="2018-10-10" version="1">MSFSYKRPFGCESGQPQLVRPHRLGELFPHQMLYVLRHYVYDGLQLPVFTALSGEIQHDLEDVDSIDFHEHAYILIKIFRAVFTLWILAIFTAIRMRLSSPSMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R408</accession>
    <name>A0A2Z5R408_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">mltG</name>
        <name evidence="11" type="synonym">yceG</name>
        <name evidence="10" type="ORF">I6I94_00540</name>
        <name evidence="11" type="ORF">NCTC10207_01195</name>
        <name evidence="9" type="ORF">RA11412_1890</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">NCTC10207</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="3">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR134479">
        <property type="protein sequence ID" value="VEI23098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023133020.1">
        <property type="nucleotide sequence ID" value="NZ_JQHE01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88189">
        <property type="protein sequence ID" value="BAV88189"/>
        <property type="gene ID" value="RA11412_1890"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_1890"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000282386">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAV88189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QQT89162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VEI23098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000282386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="406" mass="45280" checksum="286A85FA041A50DF" modified="2018-10-10" version="1">MTEDSKKRVNRTPKNKQPRKTGLRDLLSPSYEEARAGIRGITLEQEVVSVEELKARKRRRTAIMGVATIIFLVTVIVLSSLLIARLDPFKKRDFAGDGNGTAVTFVIEQGETPQQIAESLQQQGIIADADKFVEVYQSESKGKFLVPGRYDLQKEMSSSAVVSTLIGATSNVIYFAVPQGKRVGETLDIIAKQGELNRSELEEAVKNYEQYGVPSNFPSIEGWLHPGEYRFPKGTDTKKMIQAMVDKTKEDLKSVGVTTDKRAFEVLTKASIVELEAQPKDYNAVAGIIENRLSHTDGETSGLIQSDATVTYGLGIRSYHLTEEQKADKGNKYNTYAHQGLPAGPIDSPTLASIRATASPEKNPYYYWVTVDLDSGETKYSKTYEEHQRYVEEYNQWCSNHKGRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R473</accession>
    <name>A0A2Z5R473_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">pepN</name>
        <name evidence="17" type="ORF">I6I94_11250</name>
        <name evidence="16" type="ORF">RA11412_2050</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">JCM 11412</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="submission" date="2021-01" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Sproer C."/>
                <person name="Gronow S."/>
                <person name="Severitt S."/>
                <person name="Schroder I."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Zhao X."/>
                <person name="Boylan J."/>
                <person name="Ott S."/>
                <person name="Bowen H."/>
                <person name="Vavikolanu K."/>
                <person name="Mehta A."/>
                <person name="Aluvathingal J."/>
                <person name="Nadendla S."/>
                <person name="Lowell S."/>
                <person name="Myers T."/>
                <person name="Yan Y."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">FDAARGOS_1137</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP068102">
        <property type="protein sequence ID" value="QQT89058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88349">
        <property type="protein sequence ID" value="BAV88349"/>
        <property type="gene ID" value="RA11412_2050"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2050"/>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000595251">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="24"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="235"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="532"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAV88349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QQT89058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000595251"/>
        </source>
    </evidence>
    <sequence length="850" mass="95888" checksum="2E5B8103C1C66F4B" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2Z5R4H3</accession>
    <name>A0A2Z5R4H3_9MICC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipoyl(octanoyl) transferase</fullName>
            <ecNumber evidence="3">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">RA11412_2240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Rothia aeria</name>
        <dbReference type="NCBI Taxonomy" id="172042"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Micrococcales</taxon>
            <taxon>Micrococcaceae</taxon>
            <taxon>Rothia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of Rothia aeria strain JCM11412.</title>
            <authorList>
                <person name="Nambu T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 11412</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="3"/>
    <dbReference type="EMBL" id="AP017895">
        <property type="protein sequence ID" value="BAV88539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAV88539">
        <property type="protein sequence ID" value="BAV88539"/>
        <property type="gene ID" value="RA11412_2240"/>
    </dbReference>
    <dbReference type="KEGG" id="raj:RA11412_2240"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000250241">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="7">
        <location>
            <begin position="34"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAV88539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000250241"/>
        </source>
    </evidence>
    <sequence length="132" mass="14856" checksum="23A1AD47463F4AA5" modified="2018-10-10" version="1">MSVIIERVGFAPNYVNYTESLDEQRRIHAEVAERTRNNTILLLEHEAVITAGKRTEDHEYPTDKTTPVVKIDRGGKLTWHGPGQLTGYPIVRLPEPIDVVAYVRLLEEIIMNVLAEFGIKGERVEGVLACGF</sequence>
</entry>
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</copyright>
</uniprot>